SLC1A3

Summary

Gene Symbol: SLC1A3
Description: solute carrier family 1 member 3
Alias: EA6, EAAT1, GLAST, GLAST1, excitatory amino acid transporter 1, GLAST-1, sodium-dependent glutamate/aspartate transporter 1, solute carrier family 1 (glial high affinity glutamate transporter), member 3
Species: human
Products:     SLC1A3

Top Publications

  1. Turic D, Langley K, Williams H, Norton N, Williams N, Moskvina V, et al. A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005;57:1461-6 pubmed
    ..Genes related to glutamate function are therefore good functional candidates for this disorder. The SLC1A3 (Solute Carrier Family 1, member 3) gene encodes a glial glutamate transporter which maps to chromosome 5p12, a ..
  2. Leighton B, Seal R, Watts S, Skyba M, Amara S. Structural rearrangements at the translocation pore of the human glutamate transporter, EAAT1. J Biol Chem. 2006;281:29788-96 pubmed
    ..In this study, we used chemical cross-linking of introduced cysteine pairs in a cysteine-less version of EAAT1 to examine the dynamics of key domains associated with the translocation pore...
  3. Shrivastava I, Jiang J, Amara S, Bahar I. Time-resolved mechanism of extracellular gate opening and substrate binding in a glutamate transporter. J Biol Chem. 2008;283:28680-90 pubmed publisher
    ..The functional importance of Leu-303 or its counterpart Leu-391 in human EAAT1 (hEAAT1) is confirmed by site-directed mutagenesis and Na+ dependence assays conducted with hEAAT1 mutants L391C ..
  4. de Vries B, Mamsa H, Stam A, Wan J, Bakker S, Vanmolkot K, et al. Episodic ataxia associated with EAAT1 mutation C186S affecting glutamate reuptake. Arch Neurol. 2009;66:97-101 pubmed publisher
    ..At least 4 genes have been implicated. Recently, a mutation in the SLC1A3 gene encoding the glutamate transporter EAAT1 was identified in a patient with severe episodic and progressive ..
  5. Mandolesi G, Gentile A, Musella A, Centonze D. IL-1β dependent cerebellar synaptopathy in a mouse mode of multiple sclerosis. Cerebellum. 2015;14:19-22 pubmed publisher
    ..was enhanced due to a reduced expression and functioning of glutamate aspartate transporter (GLAST)/excitatory amino acid transporter 1 (EAAT1), the most abundant glutamate transporter expressed by Bergmann glia...
  6. Jung K, Kim J, Park C. α2-Adrenergic modulation of the glutamate receptor and transporter function in a chronic ocular hypertension model. Eur J Pharmacol. 2015;765:274-83 pubmed publisher
    ..b>Excitatory amino acid transporter 1(EAAT1) expression remained stable throughout the period of chronic ocular hypertension...
  7. Malar D, Prasanth M, Shafreen R, Balamurugan K, Devi K. Grewia tiliaefolia and its active compound vitexin regulate the expression of glutamate transporters and protect Neuro-2a cells from glutamate toxicity. Life Sci. 2018;203:233-241 pubmed publisher
    ..potential, suppressed the expression of antioxidant response genes (Nrf-2, HO-1, NQO-1), glutamate transporters (GLAST-1, GLT-1) and induced the expression of NMDAR, Calpain...
  8. Sawicki C, McKim D, Wohleb E, Jarrett B, Reader B, Norden D, et al. Social defeat promotes a reactive endothelium in a brain region-dependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain. Neuroscience. 2015;302:151-64 pubmed publisher
    ..Last, comparison between enriched CD11b(+) cells (microglia/macrophages) and enriched GLAST-1(+)/CD11b(-) cells (astrocytes) revealed RSD increased mRNA expression of IL-1β, CCL2, and CXCL2 in microglia/..
  9. Hu Q, Ottestad Hansen S, Holmseth S, Hassel B, Danbolt N, Zhou Y. Expression of Glutamate Transporters in Mouse Liver, Kidney, and Intestine. J Histochem Cytochem. 2018;66:189-202 pubmed publisher
    ..Neither EAAT1 nor EAAT2 was detected at significant levels in murine kidney or intestine...

More Information

Publications131 found, 100 shown here

  1. Choe K, Prager Khoutorsky M, Farmer W, Murai K, Bourque C. Effects of Salt Loading on the Morphology of Astrocytes in the Ventral Glia Limitans of the Rat Supraoptic Nucleus. J Neuroendocrinol. 2016;28: pubmed publisher
    ..labelling of a low density of astrocytes expressing glutamate and aspartate transporter (GLAST)/excitatory amino acid transporter 1. This approach revealed a high degree of variability in the morphology of mouse SON-VGL astrocytes, ..
  2. Rong X, Zomot E, Zhang X, Qu S. Investigating substrate-induced motion between the scaffold and transport domains in the glutamate transporter EAAT1. Mol Pharmacol. 2014;86:657-64 pubmed publisher
    b>Excitatory amino acid transporter 1 plays an important role in keeping the synaptic glutamate concentration below neurotoxic levels by translocating this neurotransmitter into the cell...
  3. Rauen T, Rothstein J, Wassle H. Differential expression of three glutamate transporter subtypes in the rat retina. Cell Tissue Res. 1996;286:325-36 pubmed
    The immunocytochemical distribution of the three excitatory amino acid transporter subtypes GLT-1, GLAST-1 and EAAC-1 was studied in the rat retina using antibodies raised against synthetic peptides corresponding to the C-terminus of ..
  4. dos Santos Souza C, Grangeiro M, Lima Pereira É, Dos Santos C, da Silva A, Sampaio G, et al. Agathisflavone, a flavonoid derived from Poincianella pyramidalis (Tul.), enhances neuronal population and protects against glutamate excitotoxicity. Neurotoxicology. 2018;65:85-97 pubmed publisher
    ..expression of glutamate regulatory proteins in astrocytes, namely glutamine synthetase (GS) and Excitatory Amino Acid Transporter 1 (EAAT1)...
  5. Bellaver B, Souza D, Souza D, Quincozes Santos A. Hippocampal Astrocyte Cultures from Adult and Aged Rats Reproduce Changes in Glial Functionality Observed in the Aging Brain. Mol Neurobiol. 2017;54:2969-2985 pubmed publisher
    ..Age-dependent changes were also observed in glutamate transporters (glutamate aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1)) and glutamine synthetase immunolabeling and activity...
  6. Sakurai T, Akanuma S, Usui T, Kubo Y, Tachikawa M, Hosoya K. Excitatory Amino Acid Transporter 1-Mediated L-Glutamate Transport at the Inner Blood-Retinal Barrier: Possible Role in L-Glutamate Elimination from the Retina. Biol Pharm Bull. 2015;38:1087-91 pubmed publisher
    ..polymerase chain reaction (RT-PCR) analysis and immunoblot analysis demonstrated that mRNA and protein of EAAT1 are expressed in TR-iBRB2 cells, whereas mRNAs and/or proteins of EAAT2-5 are not...
  7. Miyagishi H, Tsuji M, Saito A, Miyagawa K, Takeda H. Inhibitory effect of yokukansan on the decrease in the hippocampal excitatory amino acid transporter EAAT2 in stress-maladaptive mice. J Tradit Complement Med. 2017;7:371-374 pubmed publisher
    ..Expressions of EAAT1-4 and glial fibrillary acidic protein (GFAP), a marker of astrocytes, in the brain tissues were analyzed by ..
  8. MacNamee S, Liu K, Gerhard S, Tran C, Fetter R, Cardona A, et al. Astrocytic glutamate transport regulates a Drosophila CNS synapse that lacks astrocyte ensheathment. J Comp Neurol. 2016;524:1979-98 pubmed publisher
    ..communication was present: neuronal activation triggered astrocytic glutamate transport via excitatory amino acid transporter 1 (Eaat1), and blocking Eaat1 extended glutamatergic interneuron-evoked inhibitory postsynaptic ..
  9. Akanuma S, Sakurai T, Tachikawa M, Kubo Y, Hosoya K. Transporter-mediated L-glutamate elimination from cerebrospinal fluid: possible involvement of excitatory amino acid transporters expressed in ependymal cells and choroid plexus epithelial cells. Fluids Barriers CNS. 2015;12:11 pubmed publisher
    ..It is suggested that EAAT1 in ependymal cells and EAAT3 in choroid plexus epithelial cells participate in L-Glu elimination from the CSF.
  10. Diaper D, Adachi Y, Lazarou L, Greenstein M, Simoes F, Di Domenico A, et al. Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD. Hum Mol Genet. 2013;22:3883-93 pubmed publisher
    ..both loss and gain of Drosophila TDP-43 alter mRNA expression levels of the glutamate transporters Excitatory amino acid transporter 1 (EAAT1) and EAAT2...
  11. Chung V, Turney B. A Drosophila genetic model of nephrolithiasis: transcriptional changes in response to diet induced stone formation. BMC Urol. 2017;17:109 pubmed publisher
    ..Among these, Nervana 3, Eaat1 (Excitatory amino acid transporter 1), CG7912, CG5404, CG3036 worked as ion transmembrane transporters, which were possibly involved in ..
  12. Ghosh M, Lane M, Krizman E, Sattler R, Rothstein J, Robinson M. The transcription factor Pax6 contributes to the induction of GLT-1 expression in astrocytes through an interaction with a distal enhancer element. J Neurochem. 2016;136:262-75 pubmed publisher
    ..there was no effect on the levels of the other astroglial glutamate transporter, glutamate aspartate transporter (GLAST)...
  13. Augustine J, Pavlou S, O Hare M, Harkin K, Stitt A, Curtis T, et al. Characterization of a Spontaneously Immortalized Murine Müller Glial Cell Line QMMuC-1. Invest Ophthalmol Vis Sci. 2018;59:1666-1674 pubmed publisher
    ..express higher levels of chemokine (C-C motif) ligand 2 (Ccl2), VEGFA, and glutamate aspartate transporter (GLAST), but lower levels of interleukin 6 (IL-6), brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1 ..
  14. Mennini T, Bastone A, Crespi D, Comoletti D, Manzoni C. Spinal cord GLT-1 glutamate transporter and blood glutamic acid alterations in motor neuron degeneration (Mnd) mice. J Neurol Sci. 1998;157:31-6 pubmed
    ..GLT-1 immunoreactivity was reduced by 34% in 28-week-old Mnd mice, while GLAST immunoreactivity was not affected...
  15. Alasmari F, Abuhamdah S, Sari Y. Effects of ampicillin on cystine/glutamate antiporter and glutamate transporter 1 isoforms as well as ethanol drinking in male P rats. Neurosci Lett. 2015;600:148-52 pubmed publisher
    ..the effects of ampicillin on the expression of xCT and GLT-1 isoforms (GLT-1a and GLT-1b) as well as on GLAST expression. We found that ampicillin reduced ethanol intake as compared to the saline (control)-treated group...
  16. Alexander G, Deitch J, Seeburger J, del Valle L, Heiman Patterson T. Elevated cortical extracellular fluid glutamate in transgenic mice expressing human mutant (G93A) Cu/Zn superoxide dismutase. J Neurochem. 2000;74:1666-73 pubmed
    ..evaluated using intracerebral microdialysis and western immunoblot assays for the glutamate transporters GLT-1, GLAST, and EAAC1...
  17. Gordillo Salas M, Pilar Cuéllar F, Auberson Y, Adell A. Signaling pathways responsible for the rapid antidepressant-like effects of a GluN2A-preferring NMDA receptor antagonist. Transl Psychiatry. 2018;8:84 pubmed publisher
    ..of rapamycin (mTOR) signaling, glia markers such as glial fibrillary acidic protein (GFAP) and excitatory amino acid transporter 1 (EAAT1), and a rapid mobilization of intracellular stores of brain-derived neurotrophic factor (..
  18. Meyer M, Lara A, Hunt H, Belanoff J, de Kloet E, Gonzalez Deniselle M, et al. The Selective Glucocorticoid Receptor Modulator Cort 113176 Reduces Neurodegeneration and Neuroinflammation in Wobbler Mice Spinal Cord. Neuroscience. 2018;384:384-396 pubmed publisher
    ..Expression of glutamate transporters GLT1 and GLAST mRNAs and GLT1 protein was significantly enhanced over untreated Wobblers...
  19. Rimmele T, Rosenberg P. GLT-1: The elusive presynaptic glutamate transporter. Neurochem Int. 2016;98:19-28 pubmed publisher
    ..found to be located in presynaptic terminals of excitatory synapses; 2) the putative glial transporters, GLT-1 and GLAST are expressed at high levels in astrocytes; 3) studies of the constitutive GLT-1 knockout as well as ..
  20. Silverman J, Christy D, Shyu C, Moon K, Fernando S, Gidden Z, et al. CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1. J Biol Chem. 2019;294:3744-3759 pubmed publisher
    ..brain- and spinal cord-derived EVs, from NTg and SOD1G93A mice, are positive for the astrocyte marker GLAST and the synaptic marker SNAP25, whereas CD11b, a microglial marker, was largely absent...
  21. Morioka N, Zhang F, Nakamura Y, Kitamura T, Hisaoka Nakashima K, Nakata Y. Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice. Brain Behav Immun. 2015;49:293-310 pubmed publisher
    ..Astrocytic expression of glutamate transporter GLT-1, but not GLAST, and activity of glutamate transport were markedly decreased in mice intrathecally injected with Cx43-targeting ..
  22. Gotoh H, Nomura T, Ono K. Glycogen serves as an energy source that maintains astrocyte cell proliferation in the neonatal telencephalon. J Cereb Blood Flow Metab. 2017;37:2294-2307 pubmed publisher
    ..In the present study, we demonstrated that glycogen accumulated in glutamate aspartate transporter (GLAST)+ astrocytes in the subventricular zone and rostral migratory stream...
  23. Karki P, Smith K, Johnson J, Aschner M, Lee E. Genetic dys-regulation of astrocytic glutamate transporter EAAT2 and its implications in neurological disorders and manganese toxicity. Neurochem Res. 2015;40:380-8 pubmed publisher
    Astrocytic glutamate transporters, the excitatory amino acid transporter (EAAT) 2 and EAAT1 (glutamate transporter 1 and glutamate aspartate transporter in rodents, respectively), are the main transporters for maintaining optimal ..
  24. Odeon M, Andreu M, Yamauchi L, Grosman M, Acosta G. Chronic postnatal stress induces voluntary alcohol intake and modifies glutamate transporters in adolescent rats. Stress. 2015;18:427-34 pubmed publisher
    ..GLT-1) and excitatory amino-acid transporter-3 (EAAT-3) but increased glutamate aspartate transporter (GLAST) levels...
  25. Gentile A, Musella A, De Vito F, Fresegna D, Bullitta S, Rizzo F, et al. Laquinimod ameliorates excitotoxic damage by regulating glutamate re-uptake. J Neuroinflammation. 2018;15:5 pubmed publisher
    ..Moreover, such treatment induced an increase of Slcla3 mRNA coding for the glial glutamate-aspartate transporter (GLAST) without affecting the protein content...
  26. Velaz Faircloth M, McGraw T, alandro M, Fremeau R, Kilberg M, Anderson K. Characterization and distribution of the neuronal glutamate transporter EAAC1 in rat brain. Am J Physiol. 1996;270:C67-75 pubmed
    ..cDNAs encoding for Na(+)-dependent glutamate transporters; two are thought to be primarily glial in origin (GLAST and GLT-1) and the third (EAAC1) is localized to neurons in the brain and other nonneural tissues...
  27. Pajarillo E, Johnson J, Kim J, Karki P, Son D, Aschner M, et al. 17β-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity. Neurotoxicology. 2018;65:280-288 pubmed publisher
    ..At the molecular level, E2 and TX reversed the Mn-induced decrease of (1) glutamate aspartate transporter (GLAST) and glutamate transporter 1 (GLT-1) mRNA and protein levels; (2) transforming growth factor-α (TGF-α) and ..
  28. O Donovan S, Hasselfeld K, Bauer D, Simmons M, Roussos P, Haroutunian V, et al. Glutamate transporter splice variant expression in an enriched pyramidal cell population in schizophrenia. Transl Psychiatry. 2015;5:e579 pubmed publisher
    Dysregulation of the glutamate transporters EAAT1 and EAAT2 and their isoforms have been implicated in schizophrenia...
  29. El Sayed A, Akbar A, Iqrar I, Ali R, Norman D, Brennan M, et al. A glucanolytic Pseudomonas sp. associated with Smilax bona-nox L. displays strong activity against Phytophthora parasitica. Microbiol Res. 2018;207:140-152 pubmed publisher
    ..Among them, Pseudomonas sp. EA6 and Pseudomonas sp. EA14 displayed the highest potential for inhibition of Phytophthora...
  30. Hassel B, Iversen E, Gjerstad L, Taubøll E. Up-regulation of hippocampal glutamate transport during chronic treatment with sodium valproate. J Neurochem. 2001;77:1285-92 pubmed
    ..The level of glutamate transporters EAAT1 and EAAT2 in hippocampus also increased dose-dependently...
  31. Piao C, Ralay Ranaivo H, Rusie A, Wadhwani N, Koh S, Wainwright M. Thrombin decreases expression of the glutamate transporter GLAST and inhibits glutamate uptake in primary cortical astrocytes via the Rho kinase pathway. Exp Neurol. 2015;273:288-300 pubmed publisher
    Astrocyte glutamate transporters GLAST and GLT1 play a key role in regulating neuronal excitation and their levels are altered in patients with epilepsy, and after traumatic brain injury...
  32. de Freitas A, Ferreira D, Fernandes A, Martins R, Borges Martins V, Sathler M, et al. Caffeine alters glutamate-aspartate transporter function and expression in rat retina. Neuroscience. 2016;337:285-294 pubmed publisher
    ..Excitatory amino acid transporters (EAATs) are widely distributed among central neurons and glial cells. GLAST and GLT1 are expressed in glial cells, whereas excitatory amino acid transporter 3/excitatory amino acid carrier 1 ..
  33. Caporali P, Bruno F, Palladino G, Dragotto J, Petrosini L, Mangia F, et al. Developmental delay in motor skill acquisition in Niemann-Pick C1 mice reveals abnormal cerebellar morphogenesis. Acta Neuropathol Commun. 2016;4:94 pubmed publisher
    ..Also BG functional development was defective, as indicated by the significant reduction in GLAST and Glutamine synthetase expression...
  34. Palmada M, Kinne Saffran E, Centelles J, Kinne R. Benzodiazepines differently modulate EAAT1/GLAST and EAAT2/GLT1 glutamate transporters expressed in CHO cells. Neurochem Int. 2002;40:321-6 pubmed
    ..study is aimed to investigate whether benzodiazepines have similar effects on the two glial glutamate transporter, EAAT1 and EAAT2...
  35. Zeng K, Yang N, Wang D, Li S, Ming J, Wang J, et al. Resveratrol Prevents Retinal Dysfunction by Regulating Glutamate Transporters, Glutamine Synthetase Expression and Activity in Diabetic Retina. Neurochem Res. 2016;41:1050-64 pubmed publisher
    This study investigated the effects of resveratrol (RSV) on retinal functions, glutamate transporters (GLAST) and glutamine synthetase (GS) expression in diabetic rats retina, and on glutamate uptake, GS activity, GLAST and GS expression ..
  36. Torres Salazar D, Gonzalez Suarez A, Amara S. Transport and channel functions in EAATs: the missing link. Channels (Austin). 2016;10:86-7 pubmed publisher
  37. Neves J, Vizuete A, Nicola F, Da Ré C, Rodrigues A, Schmitz F, et al. Glial glutamate transporters expression, glutamate uptake, and oxidative stress in an experimental rat model of intracerebral hemorrhage. Neurochem Int. 2018;116:13-21 pubmed publisher
    Glial glutamate transporters (EAAT1 and EAAT2), glutamate uptake, and oxidative stress are important players in the pathogenesis of ischemic brain injury...
  38. Matsuda K, Ueda Y, Doi T, Tono T, Haruta A, Toyama K, et al. Increase in glutamate-aspartate transporter (GLAST) mRNA during kanamycin-induced cochlear insult in rats. Hear Res. 1999;133:10-6 pubmed
    Kanamycin (KM)-induced changes in expression of the gene for glutamate-aspartate transporter (GLAST) in the rat cochlea were analyzed by Northern blotting...
  39. Wang F, Xiang H, Fischer G, Liu Z, Dupont M, Hogan Q, et al. HMG-CoA synthase isoenzymes 1 and 2 localize to satellite glial cells in dorsal root ganglia and are differentially regulated by peripheral nerve injury. Brain Res. 2016;1652:62-70 pubmed publisher
    ..1, GLAST1, GDNF, and S100 but not with microglial cell marker Iba1, myelin sheath marker MBP, and neuronal marker ?3-tubulin ..
  40. Barca Mayo O, Pons Espinal M, Follert P, Armirotti A, Berdondini L, De Pietri Tonelli D. Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling. Nat Commun. 2017;8:14336 pubmed publisher
    ..Here we show that ablation of Bmal1 in GLAST-positive astrocytes alters circadian locomotor behaviour and cognition in mice...
  41. Alasmari F, Crotty Alexander L, Nelson J, Schiefer I, Breen E, Drummond C, et al. Effects of chronic inhalation of electronic cigarettes containing nicotine on glial glutamate transporters and α-7 nicotinic acetylcholine receptor in female CD-1 mice. Prog Neuropsychopharmacol Biol Psychiatry. 2017;77:1-8 pubmed publisher
    ..However, our previous studies did not reveal any changes in glutamate/aspartate transporter (GLAST) following exposure to drugs of abuse...
  42. Kirschner M, Arriza J, Copeland N, Gilbert D, Jenkins N, Magenis E, et al. The mouse and human excitatory amino acid transporter gene (EAAT1) maps to mouse chromosome 15 and a region of syntenic homology on human chromosome 5. Genomics. 1994;22:631-3 pubmed
    The gene for human excitatory amino acid transporter (EAAT1) was localized to the distal region of human chromosome 5p13 by in situ hybridization of metaphase chromosome spreads...
  43. Schmitz F, Pierozan P, Rodrigues A, Biasibetti H, Coelho D, Mussulini B, et al. Chronic Treatment with a Clinically Relevant Dose of Methylphenidate Increases Glutamate Levels in Cerebrospinal Fluid and Impairs Glutamatergic Homeostasis in Prefrontal Cortex of Juvenile Rats. Mol Neurobiol. 2016;53:2384-96 pubmed publisher
    ..Glutamate uptake was decreased by methylphenidate administration, but GLAST and GLT-1 were not altered by this treatment. In addition, the astrocyte marker GFAP was not altered by MPH...
  44. Holmqvist S, Brouwer M, Djelloul M, Diaz A, Devine M, Hammarberg A, et al. Generation of human pluripotent stem cell reporter lines for the isolation of and reporting on astrocytes generated from ventral midbrain and ventral spinal cord neural progenitors. Stem Cell Res. 2015;15:203-20 pubmed publisher
    ..These express canonical astrocyte markers NF1A, S100β, CX43, GLAST, GS and CD44...
  45. Bigini P, Bastone A, Mennini T. Glutamate transporters in the spinal cord of the wobbler mouse. Neuroreport. 2001;12:1815-20 pubmed
    ..and reactive gliosis in the cervical spinal cord, the levels of the glial glutamate transporter proteins GLT-1 and GLAST were similar in wobbler and control mice...
  46. Langer J, Gerkau N, Derouiche A, Kleinhans C, Moshrefi Ravasdjani B, Fredrich M, et al. Rapid sodium signaling couples glutamate uptake to breakdown of ATP in perivascular astrocyte endfeet. Glia. 2017;65:293-308 pubmed publisher
    ..be restricted to endfeet and immunohistochemical analysis revealed prominent expression of glutamate transporters GLAST and GLT-1 localized towards the neuropil vs. the vascular side of endfeet...
  47. Alasmari F, Rao P, Sari Y. Effects of cefazolin and cefoperazone on glutamate transporter 1 isoforms and cystine/glutamate exchanger as well as alcohol drinking behavior in male alcohol-preferring rats. Brain Res. 2016;1634:150-157 pubmed publisher
    ..xCT), which is another glial glutamate transporter co-localized with GLT-1, and glutamate/aspartate transporter (GLAST)...
  48. Novak D, Quiggle F, Artime C, Beveridge M. Regulation of glutamate transport and transport proteins in a placental cell line. Am J Physiol Cell Physiol. 2001;281:C1014-22 pubmed
    ..proteins previously associated with system X activity indicated a trend toward an increase in GLT1, EAAC1, and GLAST1 immunoreactive protein contents by 48 h; cell surface expression of the same was enhanced by 24 h...
  49. Chawla A, Johnson D, Zybura A, Leeds B, Nelson R, Hudmon A. Constitutive regulation of the glutamate/aspartate transporter EAAT1 by Calcium-Calmodulin-Dependent Protein Kinase II. J Neurochem. 2017;140:421-434 pubmed publisher
    ..The primary excitatory amino acid transporters in human astrocytes are EAAT1 and EAAT2 (GLAST and GLT-1, respectively, in rodents)...
  50. Kostić M, Zivkovic N, Cvetanovic A, Stojanovic I, Colic M. IL-17 signalling in astrocytes promotes glutamate excitotoxicity: Indications for the link between inflammatory and neurodegenerative events in multiple sclerosis. Mult Scler Relat Disord. 2017;11:12-17 pubmed publisher
    ..cultures, astrocyte ability to uptake glutamate was estimated by the alterations of glutamate transporters (GLAST and GLT-1) expression, whereas changes in glutamine synthetase expression were used to estimate the ability to ..
  51. Harada T, Harada C, Watanabe M, Inoue Y, Sakagawa T, Nakayama N, et al. Functions of the two glutamate transporters GLAST and GLT-1 in the retina. Proc Natl Acad Sci U S A. 1998;95:4663-6 pubmed
    In the retina, the glutamate transporter GLAST is expressed in Müller cells, whereas the glutamate transporter GLT-1 is found only in cones and various types of bipolar cells...
  52. Karki P, Hong P, Johnson J, Pajarillo E, Son D, Aschner M, et al. Arundic Acid Increases Expression and Function of Astrocytic Glutamate Transporter EAAT1 Via the ERK, Akt, and NF-κB Pathways. Mol Neurobiol. 2018;55:5031-5046 pubmed publisher
    ..Dysregulation of EAAT1 contributes to the pathogenesis of multiple neurological disorders, such as Alzheimer's disease (AD), ataxia, ..
  53. Ryan R, Kortt N, Sirivanta T, Vandenberg R. The position of an arginine residue influences substrate affinity and K+ coupling in the human glutamate transporter, EAAT1. J Neurochem. 2010;114:565-75 pubmed publisher
    ..Moving the arginine residue from TM8 to HP1 in EAAT1 results in a transporter that has significantly increased affinity for both glutamate and aspartate and is K(+) ..
  54. Moidunny S, Matos M, Wesseling E, Banerjee S, Volsky D, Cunha R, et al. Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity. J Neuroinflammation. 2016;13:144 pubmed publisher
    ..The expression of glutamate transporters (GLAST/EAAT1 and GLT-1/EAAT2) was investigated using real-time PCR and Western blot, and their activity was assessed by ..
  55. Gegelashvili G, Bjerrum O. Glutamate Transport System as a Novel Therapeutic Target in Chronic Pain: Molecular Mechanisms and Pharmacology. Adv Neurobiol. 2017;16:225-253 pubmed publisher
    ..High-affinity glutamate transporter subtypes GLAST/EAAT1, GLT1/EAAT2, EAAC1/EAAT3, and EAAT4, differentially expressed on sensory neurons, postsynaptic spinal ..
  56. Choi K, Kim J, Kim H, Jung I, Jeong S, Lee S, et al. Genetic Variants Associated with Episodic Ataxia in Korea. Sci Rep. 2017;7:13855 pubmed publisher
    ..Five genes (KCNA1, CACNA1A, CACNB4, SLC1A3, and UBR4) have been linked to EA...
  57. El Arfani A, Albertini G, Bentea E, Demuyser T, Van Eeckhaut A, Smolders I, et al. Alterations in the motor cortical and striatal glutamatergic system and D-serine levels in the bilateral 6-hydroxydopamine rat model for Parkinson's disease. Neurochem Int. 2015;88:88-96 pubmed publisher
    ..Using Western blotting, the expression levels of the glial glutamate transporters, GLT-1 and GLAST, as well as xCT, the specific subunit of system xc(-), and the vesicular glutamate transporters, VGLUT1 and 2 were ..
  58. Fahlke C, Kortzak D, Machtens J. Molecular physiology of EAAT anion channels. Pflugers Arch. 2016;468:491-502 pubmed publisher
    ..the synaptic cleft by a family of five glutamate transporters, the so-called excitatory amino acid transporters (EAAT1-5)...
  59. Ageta Ishihara N, Konno K, Yamazaki M, Abe M, Sakimura K, Watanabe M, et al. CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration. Neurochem Int. 2018;119:190-198 pubmed publisher
    ..tight complex with the septin heterooligomer, and that it interacts indirectly with the glutamate transporter GLAST and MYH10/nonmuscle myosin ??B...
  60. Hu X, Yang J, Sun Y, Gao X, Zhang L, Li Y, et al. Lanthanum chloride impairs memory in rats by disturbing the glutamate-glutamine cycle and over-activating NMDA receptors. Food Chem Toxicol. 2018;113:1-13 pubmed publisher
    ..an excessive accumulation of glutamate, significantly decreased the expression of glutamate/aspartate transporter (GLAST), glutamate transporter-1 (GLT-1), glutamine synthetase (GS) and phosphate-activated glutaminase (PAG), and ..
  61. Supplie L, Düking T, Campbell G, Diaz F, Moraes C, Gotz M, et al. Respiration-Deficient Astrocytes Survive As Glycolytic Cells In Vivo. J Neurosci. 2017;37:4231-4242 pubmed publisher
    ..studied astrocytes that lack mitochondrial respiration in vitro and in vivo A novel mouse mutant (GLASTCreERT2::Cox10flox/flox) was generated, in which the administration of tamoxifen ..
  62. Lee H, Finniss S, Cazacu S, Xiang C, Brodie C. Mesenchymal stem cells deliver exogenous miRNAs to neural cells and induce their differentiation and glutamate transporter expression. Stem Cells Dev. 2014;23:2851-61 pubmed publisher
    ..In addition, the delivered miR-124 increased the expression of the glutamate transporters, EAAT1 in NPCs and EAAT2 in both NPCs and astrocytes...
  63. Nagao H, Nishizawa H, Bamba T, Nakayama Y, Isozumi N, Nagamori S, et al. Increased Dynamics of Tricarboxylic Acid Cycle and Glutamate Synthesis in Obese Adipose Tissue: IN VIVO METABOLIC TURNOVER ANALYSIS. J Biol Chem. 2017;292:4469-4483 pubmed publisher
    ..Glutamate rise in obese WAT was associated with down-regulation of glutamate aspartate transporter (GLAST), a major glutamate transporter for adipocytes, and low uptake of glutamate into adipose tissue...
  64. Winter N, Kovermann P, Fahlke C. A point mutation associated with episodic ataxia 6 increases glutamate transporter anion currents. Brain. 2012;135:3416-25 pubmed publisher
  65. Morioka N, Harano S, Tokuhara M, Idenoshita Y, Zhang F, Hisaoka Nakashima K, et al. Stimulation of α7 nicotinic acetylcholine receptor regulates glutamate transporter GLAST via basic fibroblast growth factor production in cultured cortical microglia. Brain Res. 2015;1625:111-20 pubmed publisher
    ..Simulation of α7 nACh receptor leads to increased expression of glutamate/aspartate transporter (GLAST), which in turn decreases synaptic glutamate levels...
  66. Robinson M, Jackson J. Astroglial glutamate transporters coordinate excitatory signaling and brain energetics. Neurochem Int. 2016;98:56-71 pubmed publisher
    ..bulk of this activity is mediated by the astroglial glutamate transporters GLT-1 and GLAST (also called EAAT2 and EAAT1)...
  67. Fukaya M, Yamada K, Nagashima M, Tanaka K, Watanabe M. Down-regulated expression of glutamate transporter GLAST in Purkinje cell-associated astrocytes of reeler and weaver mutant cerebella. Neurosci Res. 1999;34:165-75 pubmed
    ..Glutamate transporter GLAST is highly expressed in the Bergmann glia (BG), a unipolar cerebellar astrocyte associated structurally and ..
  68. Boehmer C, Henke G, Schniepp R, Palmada M, Rothstein J, Broer S, et al. Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B. J Neurochem. 2003;86:1181-8 pubmed
    Surface expression of the glial glutamate transporter EAAT1 is stimulated by insulin-like growth factor 1 through activation of phosphatidylinositol-3-kinase...
  69. McNamara R, Asch R, Schurdak J, Lindquist D. Glutamate homeostasis in the adult rat prefrontal cortex is altered by cortical docosahexaenoic acid accrual during adolescence: An in vivo1H MRS study. Psychiatry Res Neuroimaging. 2017;270:39-45 pubmed publisher
    ..No differences were observed for markers of excitotoxicity (NAA, GFAP), or astrocyte glutamate transporter (GLAST, GLT-1) or glutamine synthetase expression...
  70. Takai S, Yamada K, Kawakami H, Tanaka K, Nakamura S. Localization of the gene (SLC1A3) encoding human glutamate transporter (GluT-1) to 5p13 by fluorescence in situ hybridization. Cytogenet Cell Genet. 1995;69:209-10 pubmed
    ..Chromosomal location of the human glutamate transporter, hGluT-1, gene (SLC1A3) was determined by fluorescence in situ hybridization. SLC1A3 was mapped to chromosome 5p13.
  71. Bar Peled O, Ben Hur H, Biegon A, Groner Y, Dewhurst S, Furuta A, et al. Distribution of glutamate transporter subtypes during human brain development. J Neurochem. 1997;69:2571-80 pubmed
    ..This requirement is handled by a family of glutamate transporters, EAAT1, EAAT2, EAAT3, and EAAT4...
  72. Lehre K, Danbolt N. The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain. J Neurosci. 1998;18:8751-7 pubmed
    ..Here we show by quantitative immunoblotting that the numbers of the astroglial glutamate transporters GLAST (EAAT1) and GLT (EAAT2) are 3200 and 12,000 per micrometer3 tissue in the stratum radiatum of adult rat hippocampus (CA1) ..
  73. Stanimirovic D, Ball R, Small D, Muruganandam A. Developmental regulation of glutamate transporters and glutamine synthetase activity in astrocyte cultures differentiated in vitro. Int J Dev Neurosci. 1999;17:173-84 pubmed
    ..Astrocytes control synaptic concentration of glutamate via the high affinity glutamate transporters, GLT-1 and GLAST, and the glutamate catabolizing enzyme, glutamine synthetase...
  74. Redecker P, Pabst H. Immunohistochemical study of the glutamate transporter proteins GLT-1 and GLAST in rat and gerbil pineal gland. J Pineal Res. 2000;28:179-84 pubmed
    ..study to explore the presence and cellular localization of the glutamate transporters GLT-1 and GLAST in rat and gerbil pineal glands...
  75. Deng X, Shibata H, Takeuchi N, Rachi S, Sakai M, Ninomiya H, et al. Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:271-8 pubmed
    ..We report here association studies of schizophrenia with three glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 encoding the glutamate transporters EAAT3, EAAT1, and EAAT4, respectively...
  76. Murphy T, RYAN M, Foster T, Kelly C, McClelland R, O Grady J, et al. Risk and protective genetic variants in suicidal behaviour: association with SLC1A2, SLC1A3, 5-HTR1B &NTRK2 polymorphisms. Behav Brain Funct. 2011;7:22 pubmed publisher
    ..genes (COMT, 5-HT2A, 5-HT1A, 5-HTR1B, TPH1, MAO-A, TPH2, DBH, CNR1, BDNF, ABCG1, GABRA5, GABRG2, GABRB2, SLC1A2, SLC1A3, NTRK2, CRHR1) were genotyped. Genotyping was performed by KBioscience...
  77. Roberts R, Roche J, McCullumsmith R. Localization of excitatory amino acid transporters EAAT1 and EAAT2 in human postmortem cortex: a light and electron microscopic study. Neuroscience. 2014;277:522-40 pubmed publisher
    ..The postmortem prefrontal cortex was processed for EAAT1 and EAAT2 immunohistochemistry...
  78. Tsai S, Chen Y, Kuo Y. High-fat diet reduces the hippocampal content level of lactate which is correlated with the expression of glial glutamate transporters. Neurosci Lett. 2018;662:142-146 pubmed publisher
    ..High-fat diet also decreased the lactate content levels and the expression of glial glutamate transporters, GLAST and GLT-1, in the hippocampus...
  79. Ye Z, Rothstein J, Sontheimer H. Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange. J Neurosci. 1999;19:10767-77 pubmed
    ..of the astrocytic glutamate transporter GLT-1 but normal expression levels of another glial glutamate transporter, GLAST. However, in glioma cells, essentially all GLAST protein was found in cell nuclei rather than the plasma membrane...
  80. Raghavendra Rao V, Rao A, Dogan A, Bowen K, Hatcher J, Rothstein J, et al. Glial glutamate transporter GLT-1 down-regulation precedes delayed neuronal death in gerbil hippocampus following transient global cerebral ischemia. Neurochem Int. 2000;36:531-7 pubmed
    Glial (GLT-1 and GLAST) and neuronal (EAAC1) high-affinity transporters mediate the sodium dependent glutamate reuptake in mammalian brain...
  81. Jen J, Wan J, Palos T, Howard B, Baloh R. Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures. Neurology. 2005;65:529-34 pubmed
    ..We looked for mutations in SLC1A3, which encodes the glutamate transporter excitatory amino acid transporter (EAAT) 1 that is important in removing ..
  82. Li T, Hou S, Mao J, Wang Y, Lu X, Tan J, et al. The expression of Dishevelled-3 and glutamine metabolism in malignant pleural mesothelioma. J Clin Pathol. 2012;65:855-8 pubmed publisher
  83. Gao W, Bi Y, Ding L, Zhu W, Ye M. SSa ameliorates the Glu uptaking capacity of astrocytes in epilepsy via AP-1/miR-155/GLAST. Biochem Biophys Res Commun. 2017;493:1329-1335 pubmed publisher
    ..reporter assay were performed to validate the relationship between miR-155-5p and glutamate aspartate transporter (GLAST). The level of Glu was sampled for HPLC measurement...
  84. Burckhardt B, Burckhardt G. Interaction of Excitatory Amino Acid Transporters 1 - 3 (EAAT1, EAAT2, EAAT3) with N-Carbamoylglutamate and N-Acetylglutamate. Cell Physiol Biochem. 2017;43:1907-1916 pubmed publisher
    ..Due to structural similarities to glutamate, NCG may be absorbed in the intestine and taken up into the liver by excitatory amino acid transporters (EAATs)...
  85. Szymocha R, Akaoka H, Dutuit M, Malcus C, Didier Bazes M, Belin M, et al. Human T-cell lymphotropic virus type 1-infected T lymphocytes impair catabolism and uptake of glutamate by astrocytes via Tax-1 and tumor necrosis factor alpha. J Virol. 2000;74:6433-41 pubmed
    ..decreased after transient contact with infected T cells, while the expression of the glial transporters GLAST and GLT-1 was decreased...
  86. Gray C, Marie H, Arora M, Tanaka K, Boyde A, Jones S, et al. Glutamate does not play a major role in controlling bone growth. J Bone Miner Res. 2001;16:742-9 pubmed
    Bone cells express glutamate-gated Ca2+-permeable N-methyl-D-aspartate (NMDA) receptors and GLAST glutamate transporters...
  87. Chandley M, Szebeni K, Szebeni A, Crawford J, Stockmeier C, Turecki G, et al. Gene expression deficits in pontine locus coeruleus astrocytes in men with major depressive disorder. J Psychiatry Neurosci. 2013;38:276-84 pubmed publisher
    ..The expression of 3 glutamate-related genes (SLC1A3, SLC1A2, GLUL) concentrated in glia and a glia gene (GFAP) were measured in postmortem tissues from men with MDD ..
  88. Piao C, Holloway A, Hong Routson S, Wainwright M. Depression following traumatic brain injury in mice is associated with down-regulation of hippocampal astrocyte glutamate transporters by thrombin. J Cereb Blood Flow Metab. 2017;:271678X17742792 pubmed publisher
    ..TBI decreases glutamate transporters GLT-1 and GLAST and allows extravasation of thrombin...
  89. Kawakami H, Tanaka K, Nakayama T, Inoue K, Nakamura S. Cloning and expression of a human glutamate transporter. Biochem Biophys Res Commun. 1994;199:171-6 pubmed
    ..The cDNA sequence predicts a protein of 542 amino acids that is highly homologous to the congeneric proteins from rat and mouse brains. RNA blotting analyses revealed the expression both in the brain and in peripheral tissues. ..
  90. Hagiwara T, Tanaka K, Takai S, Maeno Hikichi Y, Mukainaka Y, Wada K. Genomic organization, promoter analysis, and chromosomal localization of the gene for the mouse glial high-affinity glutamate transporter Slc1a3. Genomics. 1996;33:508-15 pubmed
    The mouse gene encoding glial high-affinity, Na+-dependent glutamate transporter Slc1a3 (GluT-1/GLAST) was isolated, and its structural organization was characterized...
  91. Ueda Y, Willmore L. Sequential changes in glutamate transporter protein levels during Fe(3+)-induced epileptogenesis. Epilepsy Res. 2000;39:201-9 pubmed
    ..be perturbed as a mechanism of chronic epileptogenesis, therefore levels of glutamate transporter proteins GLT-1, GLAST and EAAC-1 were measured in ipsilateral and contralateral hippocampi removed from rats having spontaneous iron-..
  92. Scott H, Pow D, Tannenberg A, Dodd P. Aberrant expression of the glutamate transporter excitatory amino acid transporter 1 (EAAT1) in Alzheimer's disease. J Neurosci. 2002;22:RC206 pubmed
    ..In this study, we examined the cellular localization of the glial glutamate transporter excitatory amino acid transporter 1 (EAAT1) in the cerebral cortex of control, Alzheimer's disease, and non-Alzheimer dementia cases...