SLC1A1

Summary

Gene Symbol: SLC1A1
Description: solute carrier family 1 member 1
Alias: DCBXA, EAAC1, EAAT3, SCZD18, excitatory amino acid transporter 3, excitatory amino acid carrier 1, neuronal and epithelial glutamate transporter, sodium-dependent glutamate/aspartate transporter 3, solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Species: human
Products:     SLC1A1

Top Publications

  1. Lin C, Orlov I, Ruggiero A, Dykes Hoberg M, Lee A, Jackson M, et al. Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18. Nature. 2001;410:84-8 pubmed
    Excitatory amino-acid carrier 1 (EAAC1) is a high-affinity Na+-dependent L-glutamate/D,L-aspartate cell-membrane transport protein. It is expressed in brain as well as several non-nervous tissues...
  2. Arnold P, Sicard T, Burroughs E, Richter M, Kennedy J. Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder. Arch Gen Psychiatry. 2006;63:769-76 pubmed
    ..This region contains the gene encoding the neuronal glutamate transporter, SLC1A1. SLC1A1 represents an excellent candidate gene for OCD based on evidence from neuroimaging and animal studies that ..
  3. Dickel D, Veenstra Vanderweele J, Cox N, Wu X, Fischer D, Van Etten Lee M, et al. Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder. Arch Gen Psychiatry. 2006;63:778-85 pubmed
    ..The glutamate transporter gene solute carrier family 1, member 1 (SLC1A1) is a promising functional candidate in this region because altered glutamatergic concentrations have been found ..
  4. Stewart S, Fagerness J, Platko J, Smoller J, Scharf J, Illmann C, et al. Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:1027-33 pubmed
    ..Two separate proximal haplotypes in the glutamate transporter gene, SLC1A1, were recently reported to be associated with OCD among males, but replication is required...
  5. Zhang Z, Tao Z, Gameiro A, Barcelona S, Braams S, Rauen T, et al. Transport direction determines the kinetics of substrate transport by the glutamate transporter EAAC1. Proc Natl Acad Sci U S A. 2007;104:18025-30 pubmed
    Glutamate transport by the excitatory amino acid carrier EAAC1 is known to be reversible...
  6. Shugart Y, Wang Y, Samuels J, Grados M, Greenberg B, Knowles J, et al. A family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder in 378 families. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:886-92 pubmed publisher
    SLC1A encodes the neuronal and epithelial glutamate transporter and was previously tested as a candidate for obsessive-compulsive disorder (OCD) by several research groups...
  7. Gadow K, Roohi J, DeVincent C, Kirsch S, Hatchwell E. Glutamate transporter gene (SLC1A1) single nucleotide polymorphism (rs301430) and repetitive behaviors and anxiety in children with autism spectrum disorder. J Autism Dev Disord. 2010;40:1139-45 pubmed publisher
    Investigated association of single nucleotide polymorphism (SNP) rs301430 in glutamate transporter gene (SLC1A1) with severity of repetitive behaviors (obsessive-compulsive behaviors, tics) and anxiety in children with autism spectrum ..
  8. Kantojärvi K, Onkamo P, Vanhala R, Alen R, Hedman M, Sajantila A, et al. Analysis of 9p24 and 11p12-13 regions in autism spectrum disorders: rs1340513 in the JMJD2C gene is associated with ASDs in Finnish sample. Psychiatr Genet. 2010;20:102-8 pubmed publisher
    ..Ten single nucleotide polymorphisms (SNPs) at 9p24 and 11p12-p13 containing glutamate transporter genes SLC1A1 and SLC1A2 and their neighboring regions in 175 patients with ASDs and 216 controls of Finnish origin were ..
  9. Ryu S, Oh S, Cho E, Nam H, Yoo J, Park T, et al. Interaction between genetic variants of DLGAP3 and SLC1A1 affecting the risk of atypical antipsychotics-induced obsessive-compulsive symptoms. Am J Med Genet B Neuropsychiatr Genet. 2011;156B:949-59 pubmed publisher
    ..the interactions between DLGAP3 and a previously reported susceptibility gene, the glutamate transporter gene SLC1A1, regarding this phenotype...

More Information

Publications107 found, 100 shown here

  1. Deng X, Shibata H, Takeuchi N, Rachi S, Sakai M, Ninomiya H, et al. Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:271-8 pubmed
    ..We report here association studies of schizophrenia with three glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 encoding the glutamate transporters EAAT3, EAAT1, and EAAT4, respectively...
  2. Brune C, Kim S, Hanna G, Courchesne E, Lord C, Leventhal B, et al. Family-Based Association Testing of OCD-associated SNPs of SLC1A1 in an autism sample. Autism Res. 2008;1:108-13 pubmed publisher
    Reports identified the neuronal glutamate transporter gene, SLC1A1 (OMIM 133550, chromosome 9p24), as a positional and functional candidate gene for obsessive-compulsive disorder (OCD)...
  3. Kwon J, Joo Y, Nam H, Lim M, Cho E, Jung M, et al. Association of the glutamate transporter gene SLC1A1 with atypical antipsychotics-induced obsessive-compulsive symptoms. Arch Gen Psychiatry. 2009;66:1233-41 pubmed publisher
    ..The glutamate transporter gene SLC1A1, which was recently reported to be associated with obsessive-compulsive disorder (OCD), is a promising candidate ..
  4. Horiuchi Y, Iida S, Koga M, Ishiguro H, Iijima Y, Inada T, et al. Association of SNPs linked to increased expression of SLC1A1 with schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2012;159B:30-7 pubmed publisher
    ..The SLC1A1 gene located at 9p24 encodes the glutamate transporter EAAT3/EAAC1...
  5. Schirmbeck F, Nieratschker V, Frank J, Englisch S, Rausch F, Meyer Lindenberg A, et al. Polymorphisms in the glutamate transporter gene SLC1A1 and obsessive-compulsive symptoms induced by second-generation antipsychotic agents. Psychiatr Genet. 2012;22:245-52 pubmed publisher
    ..secondary OCS was recently described in the gene SLC1A1 encoding the neuronal glutamate transporter excitatory amino acid carrier 1. The aim of this study was to replicate these findings in a European sample...
  6. Myles Worsley M, Tiobech J, Browning S, Korn J, Goodman S, Gentile K, et al. Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family. Am J Med Genet B Neuropsychiatr Genet. 2013;162B:87-95 pubmed publisher
    ..We investigated a deletion at the SLC1A1 glutamate transporter gene originally identified as a copy number variant exclusively carried by members of a 5-..
  7. Arriza J, Fairman W, Wadiche J, Murdoch G, Kavanaugh M, Amara S. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J Neurosci. 1994;14:5559-69 pubmed
    ..Three glutamate transporters expressed in human motor cortex, termed EAAT1, EAAT2, and EAAT3 (for excitatory amino acid transporter), have been characterized by their molecular cloning and functional ..
  8. Wendland J, Moya P, Timpano K, Anavitarte A, Kruse M, Wheaton M, et al. A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder. Arch Gen Psychiatry. 2009;66:408-16 pubmed publisher
    Recent evidence from linkage analyses and follow-up candidate gene studies supports the involvement of SLC1A1, which encodes the neuronal glutamate transporter, in the development of obsessive-compulsive disorder (OCD)...
  9. Samuels J, Wang Y, Riddle M, Greenberg B, Fyer A, McCracken J, et al. Comprehensive family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet. 2011;156B:472-7 pubmed publisher
    b>SLC1A1 encodes a neuronal glutamate transporter and is a promising candidate gene for obsessive-compulsive disorder (OCD)...
  10. Hu Q, Ottestad Hansen S, Holmseth S, Hassel B, Danbolt N, Zhou Y. Expression of Glutamate Transporters in Mouse Liver, Kidney, and Intestine. J Histochem Cytochem. 2018;66:189-202 pubmed publisher
    ..In agreement with the current view, we found high EAAT3 protein levels in the brush borders of both the distal small intestine and the renal proximal tubules...
  11. Odeon M, Andreu M, Yamauchi L, Grosman M, Acosta G. Chronic postnatal stress induces voluntary alcohol intake and modifies glutamate transporters in adolescent rats. Stress. 2015;18:427-34 pubmed publisher
    ..However, the impact of early life adverse events on glutamatergic neurotransmission may underlie increased alcohol consumption in adulthood. ..
  12. Sung C, Wen Z, Feng C, Chen C, Huang S, Chen N, et al. Potentiation of spinal glutamatergic response in the neuron-glia interactions underlies the intrathecal IL-1?-induced thermal hyperalgesia in rats. CNS Neurosci Ther. 2017;23:580-589 pubmed publisher
    ..The enhanced glutamatergic response and neuron-glia interaction potentiate the intrathecal IL-1?-activated P-p38/iNOS/NO signaling and thermal hyperalgesia. ..
  13. Dunlop J, Lou Z, McIlvain H. Properties of excitatory amino acid transport in the human U373 astrocytoma cell line. Brain Res. 1999;839:235-42 pubmed
    ..Transcripts for both the EAAT1 and EAAT3 transporter subtypes were detected but not for EAATs 2, 4, and 5...
  14. Day T, Mewani R, Starr J, Li X, Chakravarty D, Ressom H, et al. Transcriptome and Proteome Analyses of TNFAIP8 Knockdown Cancer Cells Reveal New Insights into Molecular Determinants of Cell Survival and Tumor Progression. Methods Mol Biol. 2017;1513:83-100 pubmed
    ..g., NFAT5, MALAT1, MET, FOXA1, KRAS, S100P, OSTF1) and glutamate transporter gene SLC1A1. TNFAIP8 knockdown cells also exhibited decreased expression of multiple onco-proteins (e.g...
  15. Wang H, Rascoe A, Holley D, Gouaux E, Kavanaugh M. Novel dicarboxylate selectivity in an insect glutamate transporter homolog. PLoS ONE. 2013;8:e70947 pubmed publisher
    ..These residues appear to be conserved in all eukaryotic SLC1 transporters (Asp444 and Thr448, human EAAT3 numbering) with the exception of this novel C...
  16. Mennini T, Bastone A, Crespi D, Comoletti D, Manzoni C. Spinal cord GLT-1 glutamate transporter and blood glutamic acid alterations in motor neuron degeneration (Mnd) mice. J Neurol Sci. 1998;157:31-6 pubmed
    ..Spinal EAAC1 glutamate transporter protein was significantly decreased in some but not all aged mice by 36% on average, ..
  17. Ramos Chávez L, Rendón López C, Zepeda A, Silva Adaya D, Del Razo L, Gonsebatt M. Neurological effects of inorganic arsenic exposure: altered cysteine/glutamate transport, NMDA expression and spatial memory impairment. Front Cell Neurosci. 2015;9:21 pubmed publisher
    ..expression of membrane transporters related to GSH synthesis and glutamate transport and toxicity, such as xCT, EAAC1, GLAST and GLT1, as well as LAT1, were analyzed...
  18. Cirillo G, Colangelo A, Berbenni M, Ippolito V, De Luca C, Verdesca F, et al. Purinergic Modulation of Spinal Neuroglial Maladaptive Plasticity Following Peripheral Nerve Injury. Mol Neurobiol. 2015;52:1440-1457 pubmed publisher
    ..65/76 (GAD65/67)] markers and glial [glutamate transporter (GLT1) and GLAST] and neuronal amino acid [EAAC1, vesicular glutamate transporter 1 (vGLUT1)] transporters have been evaluated...
  19. Wu L, Liao P, He L, Ren W, Yin J, Duan J, et al. Growth performance, serum biochemical profile, jejunal morphology, and the expression of nutrients transporter genes in deoxynivalenol (DON)- challenged growing pigs. BMC Vet Res. 2015;11:144 pubmed publisher
    ..Such effects includes weight loss, live injury and oxidation stress, and malabsorption of nutrients as a result of selective regulation of nutrient transporter genes such as EAAC-3, SGLT-1, PepT-1, CAT-1 and LAT-1. ..
  20. Liu K, Li J, Tan H, Du C, Xie W, Zhang Y, et al. Serotonin₆ receptors in the dorsal hippocampus regulate depressive-like behaviors in unilateral 6-hydroxydopamine-lesioned Parkinson's rats. Neuropharmacology. 2015;95:290-8 pubmed publisher
    ..Additionally, the lesion did not change the density of neuronal glutamate transporter EAAC1/5-HT6 receptor co-expressing neurons in the DH...
  21. De Luca C, Savarese L, Colangelo A, Bianco M, Cirillo G, Alberghina L, et al. Astrocytes and Microglia-Mediated Immune Response in Maladaptive Plasticity is Differently Modulated by NGF in the Ventral Horn of the Spinal Cord Following Peripheral Nerve Injury. Cell Mol Neurobiol. 2016;36:37-46 pubmed publisher
    ..with the reduction of glial aminoacid transporters (GLT1 and GlyT1) and increase of neuronal glutamate transporter EAAC1. Although the expression of GABAergic neuronal marker GAD65/67 showed no change, glutamate increase, as ..
  22. Bigini P, Bastone A, Mennini T. Glutamate transporters in the spinal cord of the wobbler mouse. Neuroreport. 2001;12:1815-20 pubmed
    ..this selective degeneration of motor neurons (resulting in strong decrease in the neuronal glutamate transporter EAAC1) and reactive gliosis in the cervical spinal cord, the levels of the glial glutamate transporter proteins GLT-1 ..
  23. Trotti D, Aoki M, Pasinelli P, Berger U, Danbolt N, Brown R, et al. Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity. J Biol Chem. 2001;276:576-82 pubmed
    ..N206S manifested a dominant negative effect on the wild-type GLT1 activity, whereas it did not affect wild-type EAAC1. These findings provide evidence for a role of the N-linked glycosylation in both cellular trafficking and ..
  24. Douen A, Akiyama K, Hogan M, Wang F, Dong L, Chow A, et al. Preconditioning with cortical spreading depression decreases intraischemic cerebral glutamate levels and down-regulates excitatory amino acid transporters EAAT1 and EAAT2 from rat cerebal cortex plasma membranes. J Neurochem. 2000;75:812-8 pubmed
    ..The neuronal isoform EAAT3 was unaffected by CSD...
  25. Meldrum B, Akbar M, Chapman A. Glutamate receptors and transporters in genetic and acquired models of epilepsy. Epilepsy Res. 1999;36:189-204 pubmed
    ..from the synaptic cleft and the extracellular space by Na+-dependent transporters (GLAST/EAAT1, GLT/EAAT2, EAAC/EAAT3, EAAT4, EAAT5)...
  26. Bobermin L, Hansel G, Scherer E, Wyse A, Souza D, Quincozes Santos A, et al. Ammonia impairs glutamatergic communication in astroglial cells: protective role of resveratrol. Toxicol In Vitro. 2015;29:2022-9 pubmed publisher
    ..to prevent all the effects triggered by ammonia: (i) decrease in glutamate uptake activity and expression of the EAAC1 glutamate transporter, the main glutamate transporter present in C6 cells; (ii) increase of glutamate release, ..
  27. Masocha W. Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during paclitaxel-induced neuropathic pain in mice. Peerj. 2015;3:e1350 pubmed publisher
    ..The 6 glutamate transporters (GLAST, GLT-1 EAAC1, EAAT4, VGLUT-1 and VGLUT-2) quantified were not significantly altered by paclitaxel treatment...
  28. Hediger M, Welbourne T. Introduction: glutamate transport, metabolism, and physiological responses. Am J Physiol. 1999;277:F477-80 pubmed
    ..M. A. Hediger discusses the expression and action of EAAC1 subtype of the human excitatory amino acid transporter. I...
  29. Mukainaka Y, Tanaka K, Hagiwara T, Wada K. Molecular cloning of two glutamate transporter subtypes from mouse brain. Biochim Biophys Acta. 1995;1244:233-7 pubmed
    ..MGLT1 has 93.9% amino acid sequence identity with the rat GLT1 and MEAAC1 has 89.3% identity with the rabbit EAAC1. MEAAC1 mRNA was expressed in brain, lung, kidney and skeletal muscle, whereas expression of MGLT1 was restricted ..
  30. Ouyang L, Tian Y, Bao Y, Xu H, Cheng J, Wang B, et al. Carnosine decreased neuronal cell death through targeting glutamate system and astrocyte mitochondrial bioenergetics in cultured neuron/astrocyte exposed to OGD/recovery. Brain Res Bull. 2016;124:76-84 pubmed publisher
    ..Carnosine also upregulated the mRNA level of neuronal glutamate transporter EAAC1 at 2h after OGD...
  31. Gassó P, Ortiz A, Mas S, Morer A, Calvo A, Bargalló N, et al. Association between genetic variants related to glutamatergic, dopaminergic and neurodevelopment pathways and white matter microstructure in child and adolescent patients with obsessive-compulsive disorder. J Affect Disord. 2015;186:284-92 pubmed publisher
    ..Six polymorphisms located in the glutamate transporter gene (SLC1A1 rs3087879), dopamine transporter gene (SLC6A3 rs4975646), dopamine receptor D3 (DRD3 rs3773679), nerve growth ..
  32. Zare Z, Tehrani M, Rezaei N, Dana Ghalebarzand B, Mohammadi M. Anxiolytic activity of paraoxon is associated with alterations in rat brain glutamatergic system. Neurotoxicol Teratol. 2019;71:32-40 pubmed publisher
    ..7 and decreased in 1 mg/kg groups. Only a significant decrease in EAAC1 protein was observed in the prefrontal cortex at 14 days following exposure to 1 mg/kg of paraoxon...
  33. Zerangue N, Kavanaugh M. Flux coupling in a neuronal glutamate transporter. Nature. 1996;383:634-7 pubmed
    ..currents and pH changes associated with flux of glutamate mediated by the human neuronal glutamate transporter EAAT3. In contrast to a previous model, we find that three sodium ions and one proton are cotransported with each ..
  34. Rauen T. Diversity of glutamate transporter expression and function in the mammalian retina. Amino Acids. 2000;19:53-62 pubmed
    ..GLAST1, GLT1, EAAC1 and EAAT5 are expressed in the retina and exhibit unique localisation and functional properties...
  35. Zhu X, Ye G, Wang Z, Luo J, Hao X. Sub-anesthetic doses of ketamine exert antidepressant-like effects and upregulate the expression of glutamate transporters in the hippocampus of rats. Neurosci Lett. 2017;639:132-137 pubmed publisher
    ..We found that the expression of EAAT2 and EAAT3 were obviously downregulated, and extracellular concentrations of glutamate were significantly increased in the ..
  36. Shashidharan P, Huntley G, Meyer T, Morrison J, Plaitakis A. Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain. Brain Res. 1994;662:245-50 pubmed
    ..Southern blot analysis revealed that the gene encoding this mRNA exists as a single copy in the human genome. ..
  37. Hotzy J, Machtens J, Fahlke C. Neutralizing aspartate 83 modifies substrate translocation of excitatory amino acid transporter 3 (EAAT3) glutamate transporters. J Biol Chem. 2012;287:20016-26 pubmed publisher
    ..attachment, V120C, M205C, and A430C, we observed time-, voltage-, and substrate-dependent alterations of EAAT3 fluorescence intensities...
  38. Zhao J, Verwer R, van Wamelen D, Qi X, Gao S, Lucassen P, et al. Prefrontal changes in the glutamate-glutamine cycle and neuronal/glial glutamate transporters in depression with and without suicide. J Psychiatr Res. 2016;82:8-15 pubmed publisher
    ..We found that neuronal located components (EAAT3, EAAT4, ASCT1, SNAT1, SNAT2) of the glutamate-glutamine cycle were increased in the ACC while the astroglia ..
  39. Liu Y, Kong X, Li F, Tan B, Li Y, Duan Y, et al. Co-dependence of genotype and dietary protein intake to affect expression on amino acid/peptide transporters in porcine skeletal muscle. Amino Acids. 2016;48:75-90 pubmed publisher
    ..Bama mini-pigs had higher (P < 0.05) mRNA levels for LAT1, SNAT2, and EAAC1, but a lower (P < 0.05) mRNA level for PepT1, compared with Landrace pigs...
  40. Arnold J, Salvatore M. Exercise-Mediated Increase in Nigral Tyrosine Hydroxylase Is Accompanied by Increased Nigral GFR-α1 and EAAC1 Expression in Aging Rats. ACS Chem Neurosci. 2016;7:227-39 pubmed publisher
    ..This exercise regimen did not affect glutamate uptake or glutamate transporter expression in striatum. However, EAAC1 expression increased in SN...
  41. Martinez Lozada Z, Guillem A, Robinson M. Transcriptional Regulation of Glutamate Transporters: From Extracellular Signals to Transcription Factors. Adv Pharmacol. 2016;76:103-45 pubmed publisher
    ..Other of these transporters (EAAC1) is expressed by neurons throughout the nervous system...
  42. Chounlamountry K, Castets F, Tell F, Kessler J. The excitatory amino acid carrier 1 (EAAC1) in the rat nucleus of the solitary tract: subcellular localization suggests no major role in glutamate clearance. Brain Struct Funct. 2016;221:1113-24 pubmed publisher
    The excitatory amino acid carrier 1 (EAAC1) is a sodium-dependent glutamate transporter widely found in the mammalian brain and mainly localized in the somatodendritic compartment of neurons...
  43. Yu H, Yan H, Wang L, Li J, Tan L, Deng W, et al. Five novel loci associated with antipsychotic treatment response in patients with schizophrenia: a genome-wide association study. Lancet Psychiatry. 2018;5:327-338 pubmed publisher
    ..cohort, we identified three novel SNPs (rs72790443 in MEGF10 [p=1·37 × 10-8], rs1471786 in SLC1A1 [p=1·77 × 10-8], and rs9291547 in PCDH7 [p=4·48 × 10-8]) that were associated ..
  44. Ottestad Hansen S, Hu Q, Follin Arbelet V, Bentea E, Sato H, Massie A, et al. The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain. Glia. 2018;66:951-970 pubmed publisher
    ..The concentration of xCT protein in hippocampus was compared with that of the EAAT3 glutamate transporter by immunoblotting using a chimeric xCT-EAAT3 protein to normalize xCT and EAAT3 labeling ..
  45. Bjørås M, Gjesdal O, Erickson J, Torp R, Levy L, Ottersen O, et al. Cloning and expression of a neuronal rat brain glutamate transporter. Brain Res Mol Brain Res. 1996;36:163-8 pubmed
    ..for a rat brain glutamate transporter (REAAC1) which has 90% amino acid and 86% nucleotide identity to the rabbit EAAC1. When REAAC1 was expressed in HeLa cells using a recombinant vaccinia-T7 virus expression system, a sodium ..
  46. Ghijsen W, da Silva Aresta Belo A, Zuiderwijk M, Lopez da Silva F. Compensatory change in EAAC1 glutamate transporter in rat hippocampus CA1 region during kindling epileptogenesis. Neurosci Lett. 1999;276:157-60 pubmed
    ..These results indicate a compensatory change of the neuronal EAAC-1 glutamate transporter in CA1 region during kindling epileptogenesis, which may be the consequence of a decrease in total transporter activity...
  47. Nieoullon A, Canolle B, Masmejean F, Guillet B, Pisano P, Lortet S. The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?. J Neurochem. 2006;98:1007-18 pubmed
    EAAC1/EAAT3 is a transporter of glutamate (Glu) present at the post-synaptic neuronal element, in opposition to the two other main transporters, GLAST/EAAT1 and GLT1/EAAT2, expressed at the excitatory amino acid (EAA) synapse by ..
  48. Kim H, Kang J, Hwang E, Kim S. Association between glutamate transporter gene polymorphisms and obsessive-compulsive disorder/trait empathy in a Korean population. PLoS ONE. 2018;13:e0190593 pubmed publisher
    ..Particularly, genetic influence of glutamate transporter gene (SLC1A1) on OCD has been frequently replicated in previous studies, but several studies did not replicate the result...
  49. Bosch D, Boonstra F, de Leeuw N, Pfundt R, Nillesen W, de Ligt J, et al. Novel genetic causes for cerebral visual impairment. Eur J Hum Genet. 2016;24:660-5 pubmed publisher
    ..genes were identified (ACP6, AMOT, ARHGEF10L, ATP6V1A, DCAF6, DLG4, GABRB2, GRIN1, GRIN2B, KCNQ3, KCTD19, RERE, SLC1A1, SLC25A16, SLC35A2, SOX5, UFSP2, UHMK1, ZFP30)...
  50. Velaz Faircloth M, McGraw T, alandro M, Fremeau R, Kilberg M, Anderson K. Characterization and distribution of the neuronal glutamate transporter EAAC1 in rat brain. Am J Physiol. 1996;270:C67-75 pubmed
    ..glutamate transporters; two are thought to be primarily glial in origin (GLAST and GLT-1) and the third (EAAC1) is localized to neurons in the brain and other nonneural tissues...
  51. Miles E, McBride B, Jia Y, Liao S, Boling J, Bridges P, et al. Glutamine synthetase and alanine transaminase expression are decreased in livers of aged vs. young beef cows and GS can be upregulated by 17β-estradiol implants. J Anim Sci. 2015;93:4500-9 pubmed publisher
    ..To determine if the relative protein content of GS, ALT, aspartate transaminase (AST), glutamate transporters (EAAC1, GLT-1), and their regulating protein (GTRAP3-18) differed in biopsied liver tissue of (a) aged vs...
  52. Wei Y, Melas P, Villaescusa J, Liu J, Xu N, Christiansen S, et al. MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a Genetic Model of Depression and Targets the Glutamate Transporter SLC1A1 (EAAT3) in Vitro. Int J Neuropsychopharmacol. 2016;19: pubmed publisher
    ..combination of in silico and in vitro analyses, we found that miR-101b targets the neuronal glutamate transporter SLC1A1 (also known as EAAC1 or EAAT3)...
  53. Domith I, Socodato R, Portugal C, Munis A, Duarte Silva A, Paes de Carvalho R. Vitamin C modulates glutamate transport and NMDA receptor function in the retina. J Neurochem. 2017;: pubmed publisher
    ..that ascorbate promotes a decrease in cell surface levels of the neuronal glutamate transporter excitatory amino acid transporter 3 (EAAT3) in retinal neuronal cultures...
  54. Gerovska D, Araúzo Bravo M. Does mouse embryo primordial germ cell activation start before implantation as suggested by single-cell transcriptomics dynamics?. Mol Hum Reprod. 2016;22:208-25 pubmed publisher
    ..We also identified new transitory E3.5 EPI markers (Sgk1, Mal, Ubxn2a, Atg16l2, Gm13102, Tcfap2c, Hexb, Slc1a1, Svip, Liph and Mier3), six new stable PE markers (Sdc4, Cpn1, Dkk1, Havcr1, F2r/Par1 and Slc7a6os) as well as ..
  55. Sopjani M, Thaçi S, Krasniqi B, Selmonaj M, Rinnerthaler M, Dërmaku Sopjani M. Regulation of Ion Channels, Cellular Carriers and Na(+)/K(+)/ATPase by Janus Kinase 3. Curr Med Chem. 2017;24:2251-2260 pubmed publisher
    ..the high-affinity Na+ coupled glucose transporter SGLT1, the excitatory amino acid transporters EAAT1, EAAT2, EAAT3 and EAAT4, the peptide transporters PepT1 and PepT2, CreaT1 and theNa+/K+-ATPase...
  56. Bauer D, Haroutunian V, Meador Woodruff J, McCullumsmith R. Abnormal glycosylation of EAAT1 and EAAT2 in prefrontal cortex of elderly patients with schizophrenia. Schizophr Res. 2010;117:92-8 pubmed publisher
    ..We did not detect N-linked glycosylation of EAAT3 in either schizophrenia or the comparison subjects in these regions...
  57. Chen M, Li X, Yan H, Wang X, Gao C. Effect of egg weight on composition, embryonic growth, and expression of amino acid transporter genes in yolk sac membranes and small intestines of the domestic pigeon (Columba livia). Poult Sci. 2016;95:1425-32 pubmed publisher
    ..with the LE, the gene expression of EAAT2 in the intestine on E13 was greater in the HE, whereas the expression of EAAT3 was lower in the HE (P < 0.05)...
  58. Noro T, Namekata K, Azuchi Y, Kimura A, Guo X, Harada C, et al. Spermidine Ameliorates Neurodegeneration in a Mouse Model of Normal Tension Glaucoma. Invest Ophthalmol Vis Sci. 2015;56:5012-9 pubmed publisher
    To assess the therapeutic potential of spermidine in mice with excitatory amino acid carrier 1 (EAAC1) deletion (EAAC1 knockout [KO] mice), a mouse model of normal tension glaucoma...
  59. Abousaab A, Lang F. Up-Regulation of Excitatory Amino Acid Transporters EAAT3 and EAAT4 by Lithium Sensitive Glycogen Synthase Kinase GSK3ß. Cell Physiol Biochem. 2016;40:1252-1260 pubmed
    ..cRNA encoding wild type EAAT3 (SLC1A1) or EAAT4 (SLC1A6) was injected into Xenopus oocytes without or with additional injection of cRNA encoding wild ..
  60. Zerangue N, Kavanaugh M. Interaction of L-cysteine with a human excitatory amino acid transporter. J Physiol. 1996;493 ( Pt 2):419-23 pubmed
    ..2. L-Cysteine was transported by the neuronal subtype EAAT3 (EAAC1) with an affinity constant of 190 microM and a maximal rate of flux similar to that of L-glutamate; the ..
  61. Smith C, Weremowicz S, Kanai Y, Stelzner M, Morton C, Hediger M. Assignment of the gene coding for the human high-affinity glutamate transporter EAAC1 to 9p24: potential role in dicarboxylic aminoaciduria and neurodegenerative disorders. Genomics. 1994;20:335-6 pubmed
  62. He Y, Janssen W, Rothstein J, Morrison J. Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit GluR2 in the rat hippocampus. J Comp Neurol. 2000;418:255-69 pubmed
    b>EAAC1, a neuron-specific glutamate transporter, is likely to play an important role in the regulation of glutamate levels in the synaptic cleft. Ultrastructural studies have demonstrated that the glutamate receptor subunit proteins (e.g...
  63. Noorlander C, de Graan P, Nikkels P, Schrama L, Visser G. Distribution of glutamate transporters in the human placenta. Placenta. 2004;25:489-95 pubmed
    ..The glutamate transporters EAAT1, EAAT2 and EAAT3 are key components of the glutamate-glutamine cycle and responsible for active transport of glutamate over the ..
  64. Duerson K, Woltjer R, Mookherjee P, Leverenz J, Montine T, Bird T, et al. Detergent-insoluble EAAC1/EAAT3 aberrantly accumulates in hippocampal neurons of Alzheimer's disease patients. Brain Pathol. 2009;19:267-78 pubmed publisher
    ..EAAC1 (also called EAAT3 or SLC1A1) is the primary glutamate transporter in forebrain neurons...
  65. Zhang J, Sheerin C, Mandel H, Banducci A, Myrick H, Acierno R, et al. Variation in SLC1A1 is related to combat-related posttraumatic stress disorder. J Anxiety Disord. 2014;28:902-7 pubmed publisher
    ..We investigated 13 SNPs in the glutamate transporter gene (SLC1A1) in relation to PTSD among combat-exposed veterans...
  66. Scifo E, Pabba M, Kapadia F, Ma T, Lewis D, Tseng G, et al. Sustained Molecular Pathology Across Episodes and Remission in Major Depressive Disorder. Biol Psychiatry. 2018;83:81-89 pubmed publisher
    ..protein 29, glutamate decarboxylase 1, metabotropic glutamate receptor 1, and excitatory amino acid transporter 3) were validated by Western blot analysis...
  67. Schultz K, Stell W. Immunocytochemical localization of the high-affinity glutamate transporter, EAAC1, in the retina of representative vertebrate species. Neurosci Lett. 1996;211:191-4 pubmed
    The glutamate transporter, EAAC1, was localized immunocytochemically in goldfish, salamander, turtle, chicken, and rat retinas, using affinity-purified oligopeptide antibodies...
  68. Tao Z, Zhang Z, Grewer C. Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1. J Biol Chem. 2006;281:10263-72 pubmed
    Substrate transport by the plasma membrane glutamate transporter EAAC1 is coupled to cotransport of three sodium ions. One of these Na(+) ions binds to the transporter already in the absence of glutamate...
  69. RUGGIERO A, Liu Y, Vidensky S, Maier S, Jung E, Farhan H, et al. The endoplasmic reticulum exit of glutamate transporter is regulated by the inducible mammalian Yip6b/GTRAP3-18 protein. J Biol Chem. 2008;283:6175-83 pubmed publisher
    GTRAP3-18 interacts with and reduces the activity of the neuronal specific Na(+)/K(+) glutamate transporter, EAAC1 both in vitro and in vivo...
  70. Porton B, Greenberg B, Askland K, Serra L, Gesmonde J, Rudnick G, et al. Isoforms of the neuronal glutamate transporter gene, SLC1A1/EAAC1, negatively modulate glutamate uptake: relevance to obsessive-compulsive disorder. Transl Psychiatry. 2013;3:e259 pubmed publisher
    The SLC1A1 gene, which encodes the neuronal glutamate transporter, EAAC1, has consistently been implicated in obsessive-compulsive disorder (OCD) in genetic studies...
  71. Li M, Underhill S, Reed C, Phillips T, Amara S, Ingram S. Amphetamine and Methamphetamine Increase NMDAR-GluN2B Synaptic Currents in Midbrain Dopamine Neurons. Neuropsychopharmacology. 2017;42:1539-1547 pubmed publisher
    ..A selective peptide inhibitor of AMPH-dependent trafficking of the neuronal excitatory amino acid transporter 3 (EAAT3) blocks potentiation, suggesting that EAAT3 internalization increases extracellular ..
  72. Sundararajan T, Manzardo A, Butler M. Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases. Gene. 2018;641:25-34 pubmed publisher
    ..g., DRD1, DRD2), calcium-related channels (e.g., CACNA1H, CACNA1B), solute transporters (e.g., SLC1A1, SLC6A2) and for neurodevelopment (e.g., ADCY1, MEF2C, NOTCH2, SHANK3)...
  73. Kiryu S, Yao G, Morita N, Kato H, Kiyama H. Nerve injury enhances rat neuronal glutamate transporter expression: identification by differential display PCR. J Neurosci. 1995;15:7872-8 pubmed
    ..with our rat cDNA led us to conclude that this clone corresponds to the rat neuronal glutamate transporter (rat EAAC1)...
  74. Shimamoto K, Shigeri Y, Yasuda Kamatani Y, Lebrun B, Yumoto N, Nakajima T. Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate transporter blockers. Bioorg Med Chem Lett. 2000;10:2407-10 pubmed
    ..amino acid transporters (EAAT1-3), while D-TBOA revealed a difference in the pharmacophores between EAAT1 and EAAT3. We also synthesized the substituent variants (methyl or naphthylmethyl derivatives) of L-TBOA...
  75. van Landeghem F, Stover J, Bechmann I, Bruck W, Unterberg A, Buhrer C, et al. Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat. Glia. 2001;35:167-79 pubmed
    ..Furthermore, ramified microglia de novo expressed the neuronal glutamate transporter EAAC1 after CCII...
  76. Watabe M, Aoyama K, Nakaki T. Regulation of glutathione synthesis via interaction between glutamate transport-associated protein 3-18 (GTRAP3-18) and excitatory amino acid carrier-1 (EAAC1) at plasma membrane. Mol Pharmacol. 2007;72:1103-10 pubmed
    Regulation of the cysteine transporter known as excitatory amino acid carrier-1 (EAAC1) for intracellular glutathione (GSH) content was investigated using human embryonic kidney (HEK) 293 cells as a model system...
  77. Wilmsdorff M, Blaich C, Zink M, Treutlein J, Bauer M, Schulze T, et al. Gene expression of glutamate transporters SLC1A1, SLC1A3 and SLC1A6 in the cerebellar subregions of elderly schizophrenia patients and effects of antipsychotic treatment. World J Biol Psychiatry. 2013;14:490-9 pubmed publisher
    ..and vermis of 10 schizophrenia patients with nine normal subjects by investigating gene expression of SLC1A3, SLC1A1 and SLC1A6 by in-situ hybridization...
  78. Potenza N, Mosca N, Mondola P, Damiano S, Russo A, De Felice B. Human miR-26a-5p regulates the glutamate transporter SLC1A1 (EAAT3) expression. Relevance in multiple sclerosis. Biochim Biophys Acta Mol Basis Dis. 2018;1864:317-323 pubmed publisher
    ..In this functional screening, miR-26a was able to interact with SLC1A1 3' UTR suppressing the reporter activity...
  79. Kanai Y, Stelzner M, Nussberger S, Khawaja S, Hebert S, Smith C, et al. The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport. J Biol Chem. 1994;269:20599-606 pubmed
    ..A search of the sequence data bases revealed weak homology of HEAAC1 to the H(+)-coupled vesicular monoamine transporter, suggesting an evolutionary link between plasma membrane and vesicular transporters. ..
  80. Takai S, Kawakami H, Nakayama T, Yamada K, Nakamura S. Localization of the gene encoding the human L-glutamate transporter (GLT-1) to 11p11.2-p13 by fluorescence in situ hybridization. Hum Genet. 1996;97:387-9 pubmed
    ..The glutamate transporter subtypes GluT-1 and EAAC1 have previously been mapped to human chromosomes 5p13 and 9p24, respectively...
  81. Welbourne T, Matthews J. Glutamate transport and renal function. Am J Physiol. 1999;277:F501-5 pubmed
    Brush border gamma-glutamyltransferase-glutaminase activity and the high-affinity glutamate transporter EAAC1 function as a unit in generating and transporting extracellular glutamate into proximal tubules as a signal that modulates ..
  82. Liang K, Wang Y, Shugart Y, Grados M, Fyer A, Rauch S, et al. Evidence for potential relationship between SLC1A1 and a putative genetic linkage region on chromosome 14q to obsessive-compulsive disorder with compulsive hoarding. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1000-2 pubmed publisher
    ..In this report, we describe a preliminary approach to deal with both complexities. SLC1A1, a glutamate transporter gene on chromosome 9p, was originally proposed to be related to OCD based on two linkage ..
  83. Wang Y, Adamczyk A, Shugart Y, Samuels J, Grados M, Greenberg B, et al. A screen of SLC1A1 for OCD-related alleles. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:675-679 pubmed publisher
    SLC1A1, which encodes the neuronal and epithelial glutamate transporter, is a promising candidate gene for obsessive-compulsive disorder (OCD)...
  84. Tao Z, Rosental N, Kanner B, Gameiro A, Mwaura J, Grewer C. Mechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101. J Biol Chem. 2010;285:17725-33 pubmed publisher
    The glutamate transporter excitatory amino acid carrier 1 (EAAC1) catalyzes the co-transport of three Na(+) ions, one H(+) ion, and one glutamate molecule into the cell, in exchange for one K(+) ion...
  85. Wu H, Wang X, Yu S, Wang D, Chen J, Jiang K, et al. Association of the candidate gene SLC1A1 and obsessive-compulsive disorder in Han Chinese population. Psychiatry Res. 2013;209:737-9 pubmed publisher
    ..and 649 controls and genotyped rs10491734, rs2228622, rs301430 and rs301443 to replicate association of the SLC1A1 gene with OCD in ethnic Han Chinese...
  86. Brooks Kayal A, Munir M, Jin H, Robinson M. The glutamate transporter, GLT-1, is expressed in cultured hippocampal neurons. Neurochem Int. 1998;33:95-100 pubmed
    There are multiple subtypes of Na+-dependent glutamate transporters. Several studies suggest that EAAC1 and EAAT4 are expressed in neurons, while GLT-1 and GLAST expression is thought to be restricted to glia...
  87. Alexander G, Deitch J, Seeburger J, del Valle L, Heiman Patterson T. Elevated cortical extracellular fluid glutamate in transgenic mice expressing human mutant (G93A) Cu/Zn superoxide dismutase. J Neurochem. 2000;74:1666-73 pubmed
    ..using intracerebral microdialysis and western immunoblot assays for the glutamate transporters GLT-1, GLAST, and EAAC1. The basal extracellular fluid levels of aspartate, glutamate, glutamine, 3,4-dihydroxyphenylacetic acid, and 5-..
  88. Raghavendra Rao V, Rao A, Dogan A, Bowen K, Hatcher J, Rothstein J, et al. Glial glutamate transporter GLT-1 down-regulation precedes delayed neuronal death in gerbil hippocampus following transient global cerebral ischemia. Neurochem Int. 2000;36:531-7 pubmed
    Glial (GLT-1 and GLAST) and neuronal (EAAC1) high-affinity transporters mediate the sodium dependent glutamate reuptake in mammalian brain...
  89. Bellini S, Fleming K, De M, McCauley J, Petroccione M, D Brant L, et al. Neuronal Glutamate Transporters Control Dopaminergic Signaling and Compulsive Behaviors. J Neurosci. 2018;38:937-961 pubmed publisher
    ..b>SIGNIFICANCE STATEMENT Genetic studies implicate Slc1a1, a gene encoding the neuronal glutamate transporter EAAC1, with obsessive-compulsive disorder (OCD)...
  90. Bar Peled O, Ben Hur H, Biegon A, Groner Y, Dewhurst S, Furuta A, et al. Distribution of glutamate transporter subtypes during human brain development. J Neurochem. 1997;69:2571-80 pubmed
    ..This requirement is handled by a family of glutamate transporters, EAAT1, EAAT2, EAAT3, and EAAT4...
  91. Rosental N, Kanner B. A conserved methionine residue controls the substrate selectivity of a neuronal glutamate transporter. J Biol Chem. 2010;285:21241-8 pubmed publisher
    ..To determine whether the corresponding methionine residue of the neuronal glutamate transporter EAAC1, Met-367, fulfills a similar role, M367L, M367C, and M367S mutants were expressed in HeLa cells and Xenopus laevis ..
  92. Watts S, Torres Salazar D, Divito C, Amara S. Cysteine transport through excitatory amino acid transporter 3 (EAAT3). PLoS ONE. 2014;9:e109245 pubmed publisher
    ..Of the five known EAAT isoforms (EAATs 1-5), only the neuronal isoform, EAAT3 (EAAC1), can efficiently transport the uncharged amino acid L-cysteine...