SLC17A8

Summary

Gene Symbol: SLC17A8
Description: solute carrier family 17 member 8
Alias: DFNA25, VGLUT3, vesicular glutamate transporter 3, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8, solute carrier family 17 (vesicular glutamate transporter), member 8
Species: human
Products:     SLC17A8

Top Publications

  1. Ruel J, Emery S, Nouvian R, Bersot T, Amilhon B, Van Rybroek J, et al. Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice. Am J Hum Genet. 2008;83:278-92 pubmed publisher
    ..We have identified SLC17A8, which encodes the vesicular glutamate transporter-3 (VGLUT3), as the gene responsible for DFNA25, an autosomal-..
  2. Mansouri Guilani N, Bernard V, Vigneault E, Vialou V, Daumas S, El Mestikawy S, et al. VGLUT3 gates psychomotor effects induced by amphetamine. J Neurochem. 2019;148:779-795 pubmed publisher
    ..These neurons are believed to establish new forms of neuronal communication. The atypical VGLUT3 is of particular interest since in the striatum this subtype is found in tonically active cholinergic interneurons ..
  3. Kim K, Payne S, Yang Hood A, Li S, Davis B, Carlquist J, et al. Vesicular Glutamatergic Transmission in Noise-induced Loss and Repair of Cochlear Ribbon Synapses. J Neurosci. 2019;: pubmed publisher
    ..glutamatergic transmission from cochlear inner hair cells in mice lacking the vesicular glutamate transporter-3 (Vglut3KO), at 9-11 weeks approximately ½ the number of synapses found in Vglut3WT were maintained ..
  4. SHEETS L, Kindt K, Nicolson T. Presynaptic CaV1.3 channels regulate synaptic ribbon size and are required for synaptic maintenance in sensory hair cells. J Neurosci. 2012;32:17273-86 pubmed publisher
    ..These synaptic defects are not attributable to loss of neurotransmission, because vglut3 mutants lacking neurotransmitter release develop relatively normal hair-cell synapses...
  5. Wang H, Zhang S, Qi J, Wang H, Cachope R, Mejías Aponte C, et al. Dorsal Raphe Dual Serotonin-Glutamate Neurons Drive Reward by Establishing Excitatory Synapses on VTA Mesoaccumbens Dopamine Neurons. Cell Rep. 2019;26:1128-1142.e7 pubmed publisher
    ..Moreover, the DR-SERT terminals making asymmetric synapses on VTA dopamine neurons coexpress vesicular glutamate transporter 3 (VGluT3; transporter for accumulation of glutamate for its synaptic release), suggesting the ..
  6. Zhang H, Pan H, Zhou C, Wei Y, Ying W, Li S, et al. Simultaneous zygotic inactivation of multiple genes in mouse through CRISPR/Cas9-mediated base editing. Development. 2018;145: pubmed publisher
    ..Next, we individually mutated vGlut3 (Slc17a8), otoferlin (Otof) and prestin (Slc26a5), three genes needed for normal hearing function...
  7. Yu F, Hao S, Yang B, Zhao Y, Zhang R, Zhang W, et al. Insulin resistance due to dietary iron overload disrupts inner hair cell ribbon synapse plasticity in male mice. Neurosci Lett. 2015;597:183-8 pubmed publisher
    ..Moreover, IR did not disrupt the expression of vesicular glutamate transporter 3 (VGLUT3), myosin VIIa and prestin in hair cells...
  8. Walters B, Liu Z, Crabtree M, Coak E, Cox B, Zuo J. Auditory hair cell-specific deletion of p27Kip1 in postnatal mice promotes cell-autonomous generation of new hair cells and normal hearing. J Neurosci. 2014;34:15751-63 pubmed publisher
    ..markers and survive to adulthood, although a portion of the newly derived inner HCs exhibit cytocauds and lack VGlut3 expression...
  9. Machado N, Abbott S, Resch J, Zhu L, Arrigoni E, Lowell B, et al. A Glutamatergic Hypothalamomedullary Circuit Mediates Thermogenesis, but Not Heat Conservation, during Stress-Induced Hyperthermia. Curr Biol. 2018;28:2291-2301.e5 pubmed publisher
    ..Retrograde rabies virus tracing revealed projections from DHAVglut2 neurons to RPaVglut3, but not to RPaGABA neurons, and identified a set of inputs to DHAVglut2 → RPa ..

More Information

Publications75

  1. Case D, Alamilla J, Gillespie D. VGLUT3 does not synergize GABA/glycine release during functional refinement of an inhibitory auditory circuit. Front Neural Circuits. 2014;8:140 pubmed publisher
    The vesicular glutamate transporter 3 (VGLUT3) is expressed at several locations not normally associated with glutamate release...
  2. Lee Y, Kim H, Ahn S. Vesicular glutamate transporter 3 is strongly upregulated in cochlear inner hair cells and spiral ganglion cells of developing circling mice. Neurosci Lett. 2015;584:320-4 pubmed publisher
    b>Vesicular glutamate transporter 3 (VGLUT3) plays a major role in hearing, and mice lacking the VGLUT3 are congenitally deaf due to absence of glutamate release at the inner hair cell afferent synapses...
  3. Akil O, Rouse S, Chan D, Lustig L. Surgical method for virally mediated gene delivery to the mouse inner ear through the round window membrane. J Vis Exp. 2015;: pubmed publisher
    ..To demonstrate the efficacy of this surgical technique, the vesicular glutamate transporter 3 knockout (VGLUT3 KO) mice will be used as an example of a mouse model of congenital deafness that ..
  4. Wang H, Morales M. Pedunculopontine and laterodorsal tegmental nuclei contain distinct populations of cholinergic, glutamatergic and GABAergic neurons in the rat. Eur J Neurosci. 2009;29:340-58 pubmed publisher
    ..ChAT), glutamic acid decarboxylase (GAD) or the vesicular glutamate transporters (vGluT1, vGluT2 and vGluT3)...
  5. Atoji Y, Karim M. Expression of vesicular glutamate transporter 3 mRNA in the brain and retina of the pigeon. J Chem Neuroanat. 2014;61-62:124-31 pubmed publisher
    ..glutamate into synaptic vesicles, are classified into three subtypes in mammalian brains: vGluT1, vGluT2, and vGluT3. VGluT3 is localized in non-glutamatergic neurons of the brain and retinal amacrine cells...
  6. Draxler P, Honsek S, Forsthuber L, Hadschieff V, Sandkühler J. VGluT3? primary afferents play distinct roles in mechanical and cold hypersensitivity depending on pain etiology. J Neurosci. 2014;34:12015-28 pubmed publisher
    ..b>Vesicular glutamate transporter 3-positive (VGluT3(+)) primary afferents, for example, have been implicated in mechanical ..
  7. Qi J, Zhang S, Wang H, Wang H, de Jesus Aceves Buendia J, Hoffman A, et al. A glutamatergic reward input from the dorsal raphe to ventral tegmental area dopamine neurons. Nat Commun. 2014;5:5390 pubmed publisher
    ..Here we report rewarding effects following activation of a DR-originating pathway consisting of vesicular glutamate transporter 3 (VGluT3) containing neurons that form asymmetric synapses onto VTA dopamine neurons that project to ..
  8. Li C, Shu Y, Wang G, Zhang H, Lu Y, Li X, et al. Characterizing a novel vGlut3-P2A-iCreER knockin mouse strain in cochlea. Hear Res. 2018;364:12-24 pubmed publisher
    ..In mouse cochlea, previous studies suggest that vesicular glutamate transporter 3 (vGlut3), also known as Slc17a8, is specifically expressed in inner hair cells (IHCs) and loss of ..
  9. Omiya Y, Uchigashima M, Konno K, Yamasaki M, Miyazaki T, Yoshida T, et al. VGluT3-expressing CCK-positive basket cells construct invaginating synapses enriched with endocannabinoid signaling proteins in particular cortical and cortex-like amygdaloid regions of mouse brains. J Neurosci. 2015;35:4215-28 pubmed publisher
    ..In the basal amygdala, vesicular glutamate transporter-3 (VGluT3) was transcribed in one-fourth of CB₁-expressing GABAergic interneurons...
  10. Suzuki Y, Kiyokage E, Sohn J, Hioki H, Toida K. Structural basis for serotonergic regulation of neural circuits in the mouse olfactory bulb. J Comp Neurol. 2015;523:262-80 pubmed publisher
    ..Through immunolabeling, we also identified vesicular glutamate transporter 3 in 5-HT neurons terminals, indicating possible glutamatergic transmission...
  11. Van Liefferinge J, Jensen C, Albertini G, Bentea E, Demuyser T, Merckx E, et al. Altered vesicular glutamate transporter expression in human temporal lobe epilepsy with hippocampal sclerosis. Neurosci Lett. 2015;590:184-8 pubmed publisher
    ..At the protein level, VGLUT1 expression remains unaltered, while VGLUT2 is significantly decreased and VGLUT3 protein is significantly increased in hippocampal biopsies from TLE patients compared to controls...
  12. Soiza Reilly M, Commons K. Quantitative analysis of glutamatergic innervation of the mouse dorsal raphe nucleus using array tomography. J Comp Neurol. 2011;519:3802-14 pubmed publisher
    ..In the same volumetric images, we studied the distribution of five antigens: VGLUT1, VGLUT2, VGLUT3, the postsynaptic protein PSD-95, and a marker for 5-HT cells, the enzyme tryptophan hydroxylase (TPOH)...
  13. Lee S, Chen L, Chen M, Ye M, Seal R, Zhou Z. An unconventional glutamatergic circuit in the retina formed by vGluT3 amacrine cells. Neuron. 2014;84:708-15 pubmed publisher
    ..Here, we report calcium-dependent glutamate release from vGluT3-expressing amacrine cells (GACs) in the mouse retina...
  14. Liu H, Pecka J, Zhang Q, Soukup G, Beisel K, He D. Characterization of transcriptomes of cochlear inner and outer hair cells. J Neurosci. 2014;34:11085-95 pubmed publisher
    ..The top 10 differentially expressed genes include Slc17a8, Dnajc5b, Slc1a3, Atp2a3, Osbpl6, Slc7a14, Bcl2, Bin1, Prkd1, and Map4k4 in IHCs and Slc26a5, C1ql1, Strc, Dnm3, ..
  15. Krasowska E, Zabłocki K, Górecki D, Swinny J. Aberrant location of inhibitory synaptic marker proteins in the hippocampus of dystrophin-deficient mice: implications for cognitive impairment in duchenne muscular dystrophy. PLoS ONE. 2014;9:e108364 pubmed publisher
    ..Similar changes were evident with the cannabinoid receptor 1, vesicular glutamate transporter 3, parvalbumin, somatostatin and the GABAA receptor alpha1 subunit...
  16. Szőnyi A, Mayer M, Cserép C, Takács V, Watanabe M, Freund T, et al. The ascending median raphe projections are mainly glutamatergic in the mouse forebrain. Brain Struct Funct. 2016;221:735-51 pubmed publisher
    ..that the majority of the projecting cells of the mouse MRR contain the vesicular glutamate transporter type 3 (vGluT3)...
  17. Yang C, Duan L, Qiao P, Zhao L, Guo L. Increased VGLUT3 involved in visceral hyperalgesia in a rat model of irritable bowel syndrome. World J Gastroenterol. 2015;21:2959-66 pubmed publisher
    To investigate the activity of vesicular glutamate transporter-3 (VGLUT3) in a visceral hyperalgesia rat model of irritable bowel syndrome, and the role of mast cells (MCs)...
  18. Lou S, Pan X, Huang T, Duan B, Yang F, Yang J, et al. Incoherent feed-forward regulatory loops control segregation of C-mechanoreceptors, nociceptors, and pruriceptors. J Neurosci. 2015;35:5317-29 pubmed publisher
    ..factor Runx1 is required to coordinate the development of these unmyelinated cutaneous sensory neurons, including VGLUT3(+) low-threshold c-mechanoreceptors (CLTMs), MrgprD(+) polymodal nociceptors, MrgprA3(+) pruriceptors, MrgprB4(+) ..
  19. Ueno M, Nakamura Y, Li J, Gu Z, Niehaus J, Maezawa M, et al. Corticospinal Circuits from the Sensory and Motor Cortices Differentially Regulate Skilled Movements through Distinct Spinal Interneurons. Cell Rep. 2018;23:1286-1300.e7 pubmed publisher
    ..in the sensory cortex do not synapse directly onto premotor interneurons, and they preferentially connect to Vglut3+ spinal interneurons...
  20. Flores E, Duggan A, Madathany T, Hogan A, Márquez F, Kumar G, et al. A non-canonical pathway from cochlea to brain signals tissue-damaging noise. Curr Biol. 2015;25:606-12 pubmed publisher
    ..Their function is unknown. Using immunoreactivity to cFos, we documented neuronal activation in the brainstem of Vglut3(-/-) mice, in which the canonical auditory pathway (activation of type-I afferents by glutamate released from ..
  21. Chitravanshi V, Kawabe K, Sapru H. Stimulation of the hypothalamic arcuate nucleus increases brown adipose tissue nerve activity via hypothalamic paraventricular and dorsomedial nuclei. Am J Physiol Heart Circ Physiol. 2016;311:H433-44 pubmed publisher
    ..Stimulation of ARCN results in the release of ?-MSH and glutamate in the DMN and PVN which, in turn, cause increases in IBATSNA and TBAT. ..
  22. Liu J, Li C, Luo Q, Yin P, Lei T, Luo F. [Herpes simplex virus-mediated RNA interference targeting vesicular glutamate transporter 3 attenuates tactile allodynia in mice]. Nan Fang Yi Ke Da Xue Xue Bao. 2016;36:1449-1455 pubmed
    ..herpes simplex virus (HSV-1) for delivering a short hairpin RNA (shRNA) targeting vesicular glutamate transporter 3 (VGLUT3) and observe its effect in alleviating allodynia in mice...
  23. Krishnaswamy A, Yamagata M, Duan X, Hong Y, Sanes J. Sidekick 2 directs formation of a retinal circuit that detects differential motion. Nature. 2015;524:466-470 pubmed publisher
    ..receive strong and selective input from an unusual excitatory amacrine cell type known as VG3-AC (vesicular glutamate transporter 3)...
  24. Peirs C, Williams S, Zhao X, Walsh C, Gedeon J, Cagle N, et al. Dorsal Horn Circuits for Persistent Mechanical Pain. Neuron. 2015;87:797-812 pubmed publisher
    ..We show that the transient expression of VGLUT3 by a discrete population of neurons in the deep dorsal horn is required for mechanical pain and that activation of ..
  25. Kim T, Soto F, Kerschensteiner D. An excitatory amacrine cell detects object motion and provides feature-selective input to ganglion cells in the mouse retina. elife. 2015;4: pubmed publisher
    ..In this study, we use 2-photon-guided patch-clamp recordings to characterize responses of vesicular glutamate transporter 3 (VGluT3)-expressing amacrine cells (ACs) to a broad set of visual stimuli...
  26. Liu D, Liu Z, Liu H, Li H, Pan X, Li Z. Brain-derived neurotrophic factor promotes vesicular glutamate transporter 3 expression and neurite outgrowth of dorsal root ganglion neurons through the activation of the transcription factors Etv4 and Etv5. Brain Res Bull. 2016;121:215-26 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) is critical for sensory neuron survival and is necessary for vesicular glutamate transporter 3 (VGLUT3) expression...
  27. del Pino I, Brotons Mas J, Marques Smith A, Marighetto A, Frick A, Marin O, et al. Abnormal wiring of CCK+ basket cells disrupts spatial information coding. Nat Neurosci. 2017;20:784-792 pubmed publisher
    ..was required for the normal integration into cortical circuits of basket cells expressing CCK and vesicular glutamate transporter 3 (VGlut3)...
  28. Guo Z, Longhurst J, Tjen A Looi S, Fu L. elPBN neurons regulate rVLM activity through elPBN-rVLM projections during activation of cardiac sympathetic afferent nerves. Am J Physiol Regul Integr Comp Physiol. 2016;311:R410-25 pubmed publisher
    ..05). The majority of these elPBN neurons contain vesicular glutamate transporter 3. In cats, epicardial bradykinin and electrical stimulation of CSAN increased the activity of elPBN ..
  29. Sos K, Mayer M, Cserép C, Takács F, Szonyi A, Freund T, et al. Cellular architecture and transmitter phenotypes of neurons of the mouse median raphe region. Brain Struct Funct. 2017;222:287-299 pubmed publisher
    ..neurons are classically identified on the basis of their serotonin (5-HT), vesicular glutamate transporter type 3 (VGLUT3), and gamma-aminobutyric acid (GABA) contents; however, the exact cellular composition of MRR regarding ..
  30. Tan X, Jahan I, Xu Y, Stock S, Kwan C, Soriano C, et al. Auditory Neural Activity in Congenitally Deaf Mice Induced by Infrared Neural Stimulation. Sci Rep. 2018;8:388 pubmed publisher
    ..Atoh1 conditional knockout, CKO), Atoh1-cre; Atoh1 f/kiNeurog1 (Neurog1 knockin, KI), and the Vglut3 knockout (Vglut3 -/-) mice...
  31. Gammelsaeter R, Coppola T, Marcaggi P, Storm Mathisen J, Chaudhry F, Attwell D, et al. A role for glutamate transporters in the regulation of insulin secretion. PLoS ONE. 2011;6:e22960 pubmed publisher
    ..By immunogold cytochemistry we show that insulin containing secretory granules express VGLUT3. Despite the fact that they have a VGLUT, the levels of glutamate in these granules are low, indicating the ..
  32. Cheng L, Duan B, Huang T, Zhang Y, Chen Y, Britz O, et al. Identification of spinal circuits involved in touch-evoked dynamic mechanical pain. Nat Neurosci. 2017;20:804-814 pubmed publisher
    ..or inflammation in mice by ablating a group of adult spinal neurons defined by developmental co-expression of VGLUT3 and Lbx1 (VT3Lbx1 neurons): the mice lost brush-evoked nocifensive responses and conditional place ..
  33. Takahashi N, Nakamuta N, Yamamoto Y. Morphology of P2X3-immunoreactive nerve endings in the rat laryngeal mucosa. Histochem Cell Biol. 2016;145:131-46 pubmed publisher
    ..P2X3-immunoreactive axon terminals were also immunoreactive to vGLUT1, vGLUT2, and vGLUT3. In addition to ramified endings, P2X3-immunoreactive nerve endings were associated with α-gustducin-..
  34. Yu F, Hao S, Yang B, Zhao Y, Zhang W, Yang J. Mild Maternal Iron Deficiency Anemia Induces Hearing Impairment Associated with Reduction of Ribbon Synapse Density and Dysregulation of VGLUT3, Myosin VIIa, and Prestin Expression in Young Guinea Pigs. Neurotox Res. 2016;29:594-604 pubmed publisher
    ..In addition, downregulation of VGLUT3 and myosin VIIa, and upregulation of prestin were observed in the cochlea of offsprings from mild maternal IDA in ..
  35. Stensrud M, Sogn C, Gundersen V. Immunogold characteristics of VGLUT3-positive GABAergic nerve terminals suggest corelease of glutamate. J Comp Neurol. 2015;523:2698-713 pubmed publisher
    ..Interestingly, the third vesicular glutamate transporter (VGLUT3) is primarily found in neurons that were anticipated to be nonglutamatergic...
  36. Higley M, Gittis A, Oldenburg I, Balthasar N, Seal R, Edwards R, et al. Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS ONE. 2011;6:e19155 pubmed publisher
    ..Striatal cholinergic interneurons (CINs) express the Type-3 vesicular glutamate transporter (VGluT3), although whether they form functional glutamatergic synapses is unclear...
  37. Renard J, Vitalis T, Rame M, Krebs M, Lenkei Z, Le Pen G, et al. Chronic cannabinoid exposure during adolescence leads to long-term structural and functional changes in the prefrontal cortex. Eur Neuropsychopharmacol. 2016;26:55-64 pubmed publisher
    ..synaptic plasticity in the PFC and (3) significant changes in the expression of PSD95 (but not synaptophysin or VGLUT3) in the medial PFC...
  38. Gangadharan V, Kuner R. Unravelling Spinal Circuits of Pain and Mechanical Allodynia. Neuron. 2015;87:673-5 pubmed publisher
    ..b>VGLUT3-expressing neurons and their polysynaptic connectivity to calretinin-expressing neurons are now identified as key ..
  39. Tien N, Kim T, Kerschensteiner D. Target-Specific Glycinergic Transmission from VGluT3-Expressing Amacrine Cells Shapes Suppressive Contrast Responses in the Retina. Cell Rep. 2016;15:1369-1375 pubmed publisher
    ..b>VGluT3-expressing amacrine cells (VG3-ACs) provide glutamatergic input to ganglion cells activated by contrast and motion...
  40. Angioni L, Cocco C, Ferri G, Argiolas A, Melis M, Sanna F. Involvement of nigral oxytocin in locomotor activity: A behavioral, immunohistochemical and lesion study in male rats. Horm Behav. 2016;83:23-38 pubmed publisher
    ..g., nigrostriatal dopaminergic neurons) and for vesicular glutamate transporters VGluT1, VGluT2 and VGluT3 (e.g., glutamatergic neurons), but not for glutamic acid decarboxylase (e.g...
  41. Gangarossa G, Guzman M, Prado V, Prado M, Daumas S, El Mestikawy S, et al. Role of the atypical vesicular glutamate transporter VGLUT3 in l-DOPA-induced dyskinesia. Neurobiol Dis. 2016;87:69-79 pubmed publisher
    ..the vesicular acetylcholine transporter (VAChT) as well as the atypical vesicular glutamate transporter type 3 (VGLUT3). TANs number and soma size are not changed...
  42. Rovira Esteban L, Peterfi Z, Vikór A, Mate Z, Szabo G, Hajos N. Morphological and physiological properties of CCK/CB1R-expressing interneurons in the basal amygdala. Brain Struct Funct. 2017;222:3543-3565 pubmed publisher
    ..that the majority of CCK/CB1R-positive interneurons expressed either the type 3 vesicular glutamate transporter (VGluT3) or the Ca2+ binding protein calbindin (Calb)...
  43. Moriyama S, Iharada M, Omote H, Moriyama Y, Hiasa M. Function and expression of a splicing variant of vesicular glutamate transporter 1. Biochim Biophys Acta Biomembr. 2017;1859:931-940 pubmed publisher
    ..VGLUT consists of three isoforms, VGLUT1, VGLUT2, and VGLUT3. The VGLUT1 variant, VGLUT1v, with an additional 75-base pair sequence derived from a second intron between exons ..
  44. Lee S, Zhang Y, Chen M, Zhou Z. Segregated Glycine-Glutamate Co-transmission from vGluT3 Amacrine Cells to Contrast-Suppressed and Contrast-Enhanced Retinal Circuits. Neuron. 2016;90:27-34 pubmed publisher
    ..of a new combination of inhibitory and excitatory neurotransmitters, namely, glycine and glutamate, by the vGluT3-expressing amacrine cell (GAC) in the mouse retina...
  45. Fyk Kolodziej B, Shimano T, Gafoor D, Mirza N, Griffith R, Gong T, et al. Dopamine in the auditory brainstem and midbrain: co-localization with amino acid neurotransmitters and gene expression following cochlear trauma. Front Neuroanat. 2015;9:88 pubmed publisher
    ..However, in the IC, DA receptor 1 (DRDA1), vesicular glutamate transporters 2 and 3 (VGLUT2, VGLUT3), GABAtp and GAD67 were reduced in expression both at the 3 days and 2 months time points...
  46. Marshak D, Chuang A, Dolino D, JACOBY R, Liu W, Long Y, et al. Synaptic connections of amacrine cells containing vesicular glutamate transporter 3 in baboon retinas. Vis Neurosci. 2015;32:E006 pubmed publisher
    ..and synaptic connections of amacrine cells in the baboon retina that contain immunoreactive vesicular glutamate transporter 3 (vGluT3)...
  47. Seal R, Edwards R. The diverse roles of vesicular glutamate transporter 3. Handb Exp Pharmacol. 2006;:137-50 pubmed
    ..Although the physiological role of VGLUT3 remains largely conjectural, several observations in vivo suggest that the glutamate release mediated by VGLUT3 ..
  48. Ryu N, Sagong B, Park H, Kim M, Lee K, Choi J, et al. Screening of the SLC17A8 gene as a causative factor for autosomal dominant non-syndromic hearing loss in Koreans. BMC Med Genet. 2016;17:6 pubmed publisher
    ..The SLC17A8 (solute carrier family 17, member 8) gene encodes vesicular glutamate transporter 3 (VGLUT3), and among its isoforms (VGLUT1-3), only VGLUT3 is expressed selectively in the inner hair ..
  49. Greene C, McMillan P, Barker S, Kurnool P, Lomax M, Burmeister M, et al. DFNA25, a novel locus for dominant nonsyndromic hereditary hearing impairment, maps to 12q21-24. Am J Hum Genet. 2001;68:254-60 pubmed
    Using linkage analysis, we identified a novel dominant locus, DFNA25, for delayed-onset, progressive, high-frequency, nonsyndromic sensorineural hearing loss in a large, multigenerational United States family of Czech descent...
  50. Murao N, Yokoi N, Honda K, Han G, Hayami T, Gheni G, et al. Essential roles of aspartate aminotransferase 1 and vesicular glutamate transporters in β-cell glutamate signaling for incretin-induced insulin secretion. PLoS ONE. 2017;12:e0187213 pubmed publisher
    ..and the vesicular glutamate transporters (VGLUT1, VGLUT2, and VGLUT3, gene symbol Slc17a7, Slc17a6, and Slc17a8, respectively), which participate in glutamate transport into secretory vesicles...
  51. Sakae D, Marti F, Lecca S, Vorspan F, Martín García E, Morel L, et al. The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens. Mol Psychiatry. 2015;20:1448-59 pubmed publisher
    ..In this study, we showed that disruption of the gene that encodes VGLUT3 (Slc17a8) markedly increased cocaine self-administration in mice...
  52. Fremeau R, Voglmaier S, Seal R, Edwards R. VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate. Trends Neurosci. 2004;27:98-103 pubmed
    ..By contrast, VGLUT3 is expressed by many cells traditionally considered to release a different classical transmitter, suggesting novel ..
  53. Ramet L, Zimmermann J, Bersot T, Poirel O, De Gois S, Silm K, et al. Characterization of a Human Point Mutation of VGLUT3 (p.A211V) in the Rodent Brain Suggests a Nonuniform Distribution of the Transporter in Synaptic Vesicles. J Neurosci. 2017;37:4181-4199 pubmed publisher
    The atypical vesicular glutamate transporter type 3 (VGLUT3) is expressed by subpopulations of neurons using acetylcholine, GABA, or serotonin as neurotransmitters...
  54. Case D, Burton S, Gedeon J, Williams S, Urban N, Seal R. Layer- and cell type-selective co-transmission by a basal forebrain cholinergic projection to the olfactory bulb. Nat Commun. 2017;8:652 pubmed publisher
    ..Here the authors show that VGLUT3+ cholinergic neurons selectively innervate deep short axon cells in specific layers and elicit robust ..
  55. Ryu N, Lee S, Park H, Lee B, Kwon T, Bok J, et al. Identification of a novel splicing mutation within SLC17A8 in a Korean family with hearing loss by whole-exome sequencing. Gene. 2017;627:233-238 pubmed publisher
    ..As the result, A novel splicing mutation, c.763+1G>T, in the solute carrier family 17, member 8 (SLC17A8) gene was identified in the patients, and the genotypes of the mutation were co-segregated with the phenotype of ..
  56. Gong J, Jellali A, Mutterer J, Sahel J, Rendon A, Picaud S. Distribution of vesicular glutamate transporters in rat and human retina. Brain Res. 2006;1082:73-85 pubmed
    ..Pi) transporter), and its homologs DNPI/VGLUT2 (differentiation-associated sodium-dependent Pi transporter) and VGLUT3. We investigated the subcellular distributions of these three vesicular transporters in rat and human retina...
  57. Nectow A, Schneeberger M, Zhang H, Field B, Renier N, Azevedo E, et al. Identification of a Brainstem Circuit Controlling Feeding. Cell. 2017;170:429-442.e11 pubmed publisher
    ..raphe nucleus, expressing vesicular transporters for GABA or glutamate (hereafter, DRNVgat and DRNVGLUT3 neurons), are reciprocally activated by changes in energy balance and that modulating their activity has ..
  58. Hsiang J, Johnson K, Madisen L, Zeng H, Kerschensteiner D. Local processing in neurites of VGluT3-expressing amacrine cells differentially organizes visual information. elife. 2017;6: pubmed publisher
    ..Here, we used two-photon Ca2+ imaging to study visual processing in VGluT3-expressing amacrine cells (VG3-ACs) in the mouse retina. Contrast preferences (ON vs...
  59. Dong J, Jin G, Wu C, Guo H, Zhou B, Lv J, et al. Genome-wide association study identifies a novel susceptibility locus at 12q23.1 for lung squamous cell carcinoma in han chinese. PLoS Genet. 2013;9:e1003190 pubmed publisher
    ..We found that rs12296850 in SLC17A8-NR1H4 gene region at12q23...
  60. Divito C, Steece Collier K, Case D, Williams S, Stancati J, Zhi L, et al. Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease. J Neurosci. 2015;35:14983-99 pubmed publisher
    ..The vesicular glutamate transporter 3 (VGLUT3) is expressed by striatal cholinergic interneurons (CINs) and is thus well positioned to ..
  61. Takamori S, Malherbe P, Broger C, Jahn R. Molecular cloning and functional characterization of human vesicular glutamate transporter 3. EMBO Rep. 2002;3:798-803 pubmed
  62. Horváth H, Fazekas C, Balazsfi D, Jain S, Haller J, Zelena D. Contribution of Vesicular Glutamate Transporters to Stress Response and Related Psychopathologies: Studies in VGluT3 Knockout Mice. Cell Mol Neurobiol. 2018;38:37-52 pubmed publisher
    ..Most of our knowledge comes from the VGluT3 knockout mice, as VGluT1 and 2 knockouts are not viable...
  63. Chen M, Lee S, Zhou Z. Local synaptic integration enables ON-OFF asymmetric and layer-specific visual information processing in vGluT3 amacrine cell dendrites. Proc Natl Acad Sci U S A. 2017;114:11518-11523 pubmed publisher
    ..However, recent studies have found that vGluT3-expressing glutamatergic amacrine cells (GACs) generate ON-OFF somatic responses and release glutamate onto both ..
  64. Haugas M, Tikker L, Achim K, Salminen M, Partanen J. Gata2 and Gata3 regulate the differentiation of serotonergic and glutamatergic neuron subtypes of the dorsal raphe. Development. 2016;143:4495-4508 pubmed
    ..The newly born serotonergic precursors are segregated into distinct subpopulations expressing vesicular glutamate transporter 3 (Vglut3) or serotonin transporter (Sert)...
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    ..b>VGLUT3 immunoreactivity was less abundant in the developing myenteric plexus than those of VGLUT1 and VGLUT2 ..
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    ..Docking of VGLUT1 substrates to this pore localizes two different binding sites, to which inhibitors also bind with an overall trend in binding affinity that is in agreement with previously published experimental data. ..