Gene Symbol: SLC17A7
Description: solute carrier family 17 member 7
Alias: BNPI, VGLUT1, vesicular glutamate transporter 1, brain-specific Na(+)-dependent inorganic phosphate cotransporter, brain-specific Na-dependent inorganic phosphate cotransporter, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7, solute carrier family 17 (vesicular glutamate transporter), member 7
Species: human
Products:     SLC17A7

Top Publications

  1. Eastwood S, Harrison P. Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons. Schizophr Res. 2005;73:159-72 pubmed
    ..In these areas, VGLUT1 and complexin II are expressed primarily by excitatory neurons, whereas complexin I is mainly expressed by ..
  2. Mongredien R, Erdozain A, Dumas S, Cutando L, Del Moral A, Puighermanal E, et al. Cartography of hevin-expressing cells in the adult brain reveals prominent expression in astrocytes and parvalbumin neurons. Brain Struct Funct. 2019;: pubmed publisher
    ..2) subsets of glutamatergic neurons, identified by the expression of the vesicular glutamate transporters VGLUT1 and VGLUT2; and (3) the majority of cholinergic neurons from motor nuclei...
  3. Angioni L, Cocco C, Ferri G, Argiolas A, Melis M, Sanna F. Involvement of nigral oxytocin in locomotor activity: A behavioral, immunohistochemical and lesion study in male rats. Horm Behav. 2016;83:23-38 pubmed publisher
    ..g., nigrostriatal dopaminergic neurons) and for vesicular glutamate transporters VGluT1, VGluT2 and VGluT3 (e.g., glutamatergic neurons), but not for glutamic acid decarboxylase (e.g...
  4. Driessen A, Farrell M, Dutschmann M, Stanic D, McGovern A, Mazzone S. Reflex regulation of breathing by the paratrigeminal nucleus via multiple bulbar circuits. Brain Struct Funct. 2018;223:4005-4022 pubmed publisher
    ..although a population (~ 30%) of larger diameter myelinated jugular neurons was defined by the expression of vGlut1. Within the brainstem, vagal afferent terminals were confined to the caudal two-thirds of the paratrigeminal ..
  5. Zhuang X, Sun W, Xu Friedman M. Changes in Properties of Auditory Nerve Synapses following Conductive Hearing Loss. J Neurosci. 2017;37:323-332 pubmed publisher
    ..Consistent with this, synaptic puncta immunopositive for VGLUT1 decreased in area after occlusion...
  6. Yasui M, Menjyo Y, Tokizane K, Shiozawa A, Tsuda M, Inoue K, et al. Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome. J Neuroinflammation. 2019;16:67 pubmed publisher
    ..More than 50% of ATF3-positive neurons simultaneously expressed the proprioceptor markers TrkC or VGluT1, whereas the co-expression rates for TrkA, TrkB, IB4, and CGRP were lower than 20%...
  7. Wesseling H, Xu B, Want E, Holmes E, Guest P, Karayiorgou M, et al. System-based proteomic and metabonomic analysis of the Df(16)A+/- mouse identifies potential miR-185 targets and molecular pathway alterations. Mol Psychiatry. 2017;22:384-395 pubmed publisher
    ..phosphatase 2B catalytic subunit gamma isoform, neurofilament light chain and vesicular glutamate transporter 1. Furthermore, alterations in the proteins associated with mammalian target of rapamycin signalling ..
  8. Rühling S, Kramer F, Schmutz S, Amor S, Jiangshan Z, Schmitz C, et al. Visualization of the Breakdown of the Axonal Transport Machinery: a Comparative Ultrastructural and Immunohistochemical Approach. Mol Neurobiol. 2018;: pubmed publisher
    ..Besides APP, vesicular glutamate transporter 1 and mitochondrial proteins accumulated at sites of axonal spheroids...
  9. Hulse R, Drake R, Bates D, Donaldson L. The control of alternative splicing by SRSF1 in myelinated afferents contributes to the development of neuropathic pain. Neurobiol Dis. 2016;96:186-200 pubmed publisher
    ..large diameter myelinated (NF200-rich) dorsal root ganglia sensory neurons and their excitatory central terminals (vGLUT1+ve) within the dorsal horn of the lumbar spinal cord...

More Information

Publications119 found, 100 shown here

  1. Vahid Ansari F, Albert P. Chronic Fluoxetine Induces Activity Changes in Recovery From Poststroke Anxiety, Depression, and Cognitive Impairment. Neurotherapeutics. 2018;15:200-215 pubmed publisher
    ..To assess chronic cellular activation, FosB+ cells were co-labeled for markers of glutamate/pyramidal (VGluT1-3/CaMKIIα), γ-aminobutyric acid (GAD67), and serotonin (TPH)...
  2. Hammoum I, Benlarbi M, Dellaa A, Kahloun R, Messaoud R, Amara S, et al. Retinal dysfunction parallels morphologic alterations and precede clinically detectable vascular alterations in Meriones shawi, a model of type 2 diabetes. Exp Eye Res. 2018;176:174-187 pubmed publisher
    ..Imunohistochemistry detected a decrease in the expression of glutamate synthetase, vesicular glutamate transporter 1 and synaptophysin proteins...
  3. Shepard R, Coutellier L. Changes in the Prefrontal Glutamatergic and Parvalbumin Systems of Mice Exposed to Unpredictable Chronic Stress. Mol Neurobiol. 2018;55:2591-2602 pubmed publisher
    ..We further showed that the expression of pre- and postsynaptic markers of glutamatergic transmission (VGlut1 presynaptic terminals and pERK1/2, respectively) onto PV neurons was increased by 2 weeks of UCMS in a sex-..
  4. Ramos Miguel A, Honer W, Boyda H, Sawada K, Beasley C, Procyshyn R, et al. Exercise prevents downregulation of hippocampal presynaptic proteins following olanzapine-elicited metabolic dysregulation in rats: Distinct roles of inhibitory and excitatory terminals. Neuroscience. 2015;301:298-311 pubmed publisher
    ..of sedentary animals (n=8) were co-immunolabeled with antibodies against vesicular GABA (VGAT) and glutamate (VGLUT1) transporters, along with syntaxin-1, and examined by confocal microscopy to detect selective olanzapine effects ..
  5. Kim K, Choi C, Gonzales E, Mabunga D, Lee S, Jeon S, et al. Valproic Acid Induces Telomerase Reverse Transcriptase Expression during Cortical Development. Exp Neurobiol. 2017;26:252-265 pubmed publisher
    ..of glutamatergic markers such as Ngn2 and NeuroD1, and inter-synaptic markers such as PSD-95, ?-CaMKII, vGluT1 and synaptophysin...
  6. McCarthy C, Tomasella E, Malet M, Seroogy K, Hökfelt T, Villar M, et al. Axotomy of tributaries of the pelvic and pudendal nerves induces changes in the neurochemistry of mouse dorsal root ganglion neurons and the spinal cord. Brain Struct Funct. 2016;221:1985-2004 pubmed publisher
    ..IR) DRG NPs, as compared to their expression in uninjured DRGs (contralateral L6-S1-AXO; sham mice); VGLUT1 expression remained unaltered...
  7. Kannan G, Crawford J, Yang C, Gressitt K, Ihenatu C, Krasnova I, et al. Anti-NMDA receptor autoantibodies and associated neurobehavioral pathology in mice are dependent on age of first exposure to Toxoplasma gondii. Neurobiol Dis. 2016;91:307-14 pubmed publisher
    ..regional brain expression of N-methyl-d-aspartate receptor (NMDAR) subunits (GLUN1 and GLUN2A), glutamatergic (vGLUT1, PSD95) and GABAergic (GAD67) markers, and monoamines (DA, NE, 5-HT) and their metabolites were measured...
  8. Sotoca J, Alvarado J, Fuentes Santamaría V, Martinez Galan J, Caminos E. Hearing impairment in the P23H-1 retinal degeneration rat model. Front Neurosci. 2014;8:297 pubmed publisher
    ..In the cochlear nucleus (CN), statistical differences were found between SD and P23H-1 rats in VGluT1 distribution, but none were found when labeling all the CN synapses with anti-Syntaxin...
  9. McGuire B, Fiorillo B, Ryugo D, Lauer A. Auditory nerve synapses persist in ventral cochlear nucleus long after loss of acoustic input in mice with early-onset progressive hearing loss. Brain Res. 2015;1605:22-30 pubmed publisher
    ..We found no change in VCN volume, number of macroneurons, or number of VGLUT1-positive auditory nerve terminals between young adult and older, deaf DBA/2J...
  10. Bitencourt R, Alpár A, Cinquina V, Ferreira S, Pinheiro B, Lemos C, et al. Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents. Neurochem Int. 2015;90:72-84 pubmed publisher
    ..analysis of cortical and hippocampal regions revealed vesicular GABA transporter-positive and vesicular glutamate transporter 1-positive nerve terminals endowed with CB1R immunoreactivity, apposing GcR-positive post-synaptic ..
  11. Demeter K, Török B, Fodor A, Varga J, Ferenczi S, Kovács K, et al. Possible contribution of epigenetic changes in the development of schizophrenia-like behavior in vasopressin-deficient Brattleboro rats. Behav Brain Res. 2016;300:123-34 pubmed publisher
    ..DNA methyltransferase1 (DNMT1), DNMT3a, as well as COMT, GAD, VGLUT1, 5HT2A, BDNF mRNA levels in prefrontal brain region and hippocampus were studied by qRT-PCR...
  12. van der Hel W, Hessel E, Bos I, Mulder S, Verlinde S, van Eijsden P, et al. Persistent reduction of hippocampal glutamine synthetase expression after status epilepticus in immature rats. Eur J Neurosci. 2014;40:3711-9 pubmed publisher
    ..5%) after SE. Immunoreactivity for excitatory amino-acid transporters, vesicular glutamate transporter 1 and glial fibrillary acidic protein was unaffected...
  13. Wang Y, Wang Y, Jiang H, Liu J, Jia J, Wang K, et al. Impaired glutamatergic projection from the motor cortex to the subthalamic nucleus in 6-hydroxydopamine-lesioned hemi-parkinsonian rats. Exp Neurol. 2018;300:135-148 pubmed publisher
    ..Glutamatergic terminals identified by a specific marker (vesicular glutamate transporter 1) were reduced in the STN, while glutamatergic neurons showed an insignificant change in their total ..
  14. Khlghatyan J, Evstratova A, Chamberland S, Marakhovskaia A, Bahremand A, Toth K, et al. Mental Illnesses-Associated Fxr1 and Its Negative Regulator Gsk3β Are Modulators of Anxiety and Glutamatergic Neurotransmission. Front Mol Neurosci. 2018;11:119 pubmed publisher
    ..via regulation of AMPA receptor subunits GluA1 and GluA2 as well as vesicular glutamate transporter VGlut1. These results underscore a potential mechanism underlying the action of Fxr1 on neuronal activity and behaviors...
  15. Potter L, Paylor J, Suh J, Tenorio G, Caliaperumal J, Colbourne F, et al. Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis. J Neuroinflammation. 2016;13:142 pubmed publisher
    ..IHC revealed increased vesicular glutamate transporter (VGLUT1) expression and disrupted parvalbumin+ (PV+) interneuron connectivity in S1 of EAE mice...
  16. Nakadate K. Developmental changes in the flotillin-1 expression pattern of the rat visual cortex. Neuroscience. 2015;292:101-11 pubmed publisher
    ..experiments with anti-microtubule-associated protein 2, anti-neurofilament, anti-synaptophysin, anti-vesicular glutamate transporter 1, anti-vesicular glutamate transporter 2, anti-glial fibrillary acidic protein, and flotillin-1 ..
  17. Sidhu V, Huang B, Desai A, Kevala K, Kim H. Role of DHA in aging-related changes in mouse brain synaptic plasma membrane proteome. Neurobiol Aging. 2016;41:73-85 pubmed publisher
    ..25, synaptosomal-associated protein-α, N-methyl-D-aspartate receptor subunit epsilon-2 precursor, AMPA2, AP2, VGluT1, munc18-1, dynamin-1, vesicle-associated membrane protein 2, rab3A, and EAAT1, most of which are involved in ..
  18. Hari A, Cruz S, Qin Z, Couture P, Vilmundarson R, Huang H, et al. IRF2BP2-deficient microglia block the anxiolytic effect of enhanced postnatal care. Sci Rep. 2017;7:9836 pubmed publisher
    ..On the other hand, the glutamate transporter VGLUT1 (Slc17a7) was increased by EPC in WT but not KO mice...
  19. Coudé D, Parent A, Parent M. Single-axon tracing of the corticosubthalamic hyperdirect pathway in primates. Brain Struct Funct. 2018;223:3959-3973 pubmed publisher
    ..Our ultrastructural analysis reveals a high synaptic incidence (141%) of cortical VGluT1-immunoreactive axon varicosities on distal dendrites of STN neurons, and on various afferent axons...
  20. Morita Isogai Y, Sato H, Saito M, Kuramoto E, Yin D, Kaneko T, et al. A distinct functional distribution of α and γ motoneurons in the rat trigeminal motor nucleus. Brain Struct Funct. 2017;222:3231-3239 pubmed publisher
    ..Consistent with the size concept of motor units, the presence of smaller jaw-closing αMNs was coherent with the inclusion of jaw-closing muscle fibers with smaller diameters compared to limb muscle fibers. ..
  21. Machado N, Simões A, Silva H, Ardais A, Kaster M, Garção P, et al. Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses. Mol Neurobiol. 2017;54:1552-1563 pubmed publisher
    ..HM also had reduced density of synaptic (synaptophysin, SNAP-25), namely, glutamatergic (vGluT1; -22?±?7 %) and GABAergic (vGAT; -23?±?8 %) markers in the hippocampus...
  22. Schäck L, Budde S, Lenarz T, Krettek C, Gross G, Windhagen H, et al. Induction of neuronal-like phenotype in human mesenchymal stem cells by overexpression of Neurogenin1 and treatment with neurotrophins. Tissue Cell. 2016;48:524-32 pubmed publisher
    ..The induction of expression of the vesicular glutamate transporter 1 was identified on gene and protein level...
  23. Erburu M, Muñoz Cobo I, Diaz Perdigon T, Mellini P, Suzuki T, Puerta E, et al. SIRT2 inhibition modulate glutamate and serotonin systems in the prefrontal cortex and induces antidepressant-like action. Neuropharmacology. 2017;117:195-208 pubmed publisher
    ..effect of SIRT2 inhibition on the expression of synaptic plasticity markers linked to glutamate neurotransmission (VGLUT1, synaptophysin, mGluR4, GluA1, GluN2B, GluN2A) and on serotonin levels was studied...
  24. Moyano P, Frejo M, Anadon M, Garcia J, Díaz M, Lobo M, et al. SN56 neuronal cell death after 24 h and 14 days chlorpyrifos exposure through glutamate transmission dysfunction, increase of GSK-3β enzyme, β-amyloid and tau protein levels. Toxicology. 2018;402-403:17-27 pubmed publisher
    ..CPF increases glutaminase activity and upregulates the VGLUT1 gene expression, which could mediate the disruption of glutamatergic transmission...
  25. Wang H, Morales M. Pedunculopontine and laterodorsal tegmental nuclei contain distinct populations of cholinergic, glutamatergic and GABAergic neurons in the rat. Eur J Neurosci. 2009;29:340-58 pubmed publisher
    ..choline acetyltransferase (ChAT), glutamic acid decarboxylase (GAD) or the vesicular glutamate transporters (vGluT1, vGluT2 and vGluT3)...
  26. Wang Y, Dong J, Wang Y, Wei W, Song B, Shan Z, et al. Developmental Hypothyroxinemia and Hypothyroidism Reduce Parallel Fiber-Purkinje Cell Synapses in Rat Offspring by Downregulation of Neurexin1/Cbln1/GluD2 Tripartite Complex. Biol Trace Elem Res. 2016;173:465-74 pubmed publisher
    ..Accordingly, the mean intensity of vesicular glutamate transporter (VGluT1) and Calbindin immunofluorescence was reduced in mild ID, severe ID, and MMZ groups...
  27. Wang Y, Zhou Z, Leylek T, Tan H, Sun Y, Parkinson F, et al. Protein cysteine S-nitrosylation inhibits vesicular uptake of neurotransmitters. Neuroscience. 2015;311:374-81 pubmed publisher
    ..VAChT) is responsible for the uptake of acetylcholine, while vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2) are responsible for the uptake of glutamate...
  28. Klawonn A, Nilsson A, Rådberg C, Lindstrom S, Ericson M, Granseth B, et al. The Sigma-2 Receptor Selective Agonist Siramesine (Lu 28-179) Decreases Cocaine-Reinforced Pavlovian Learning and Alters Glutamatergic and Dopaminergic Input to the Striatum. Front Pharmacol. 2017;8:714 pubmed publisher
    ..suggests co-expression of progesterone receptor membrane component 1/sigma-2 receptors and vesicular glutamate transporter 1 in presynaptic boutons of the nucleus accumbens (NAc)...
  29. Cheng A, Zhao T, Tse K, Chow H, Cui Y, Jiang L, et al. ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle populations. Proc Natl Acad Sci U S A. 2018;115:E292-E301 pubmed publisher
    ..Superresolution microscopy and coimmunoprecipitation reveal that ATM associates exclusively with excitatory (VGLUT1+) vesicles, while ATR associates only with inhibitory (VGAT+) vesicles...
  30. Palmfeldt J, Henningsen K, Eriksen S, Müller H, Wiborg O. Protein biomarkers of susceptibility and resilience to stress in a rat model of depression. Mol Cell Neurosci. 2016;74:87-95 pubmed publisher
    ..on depression regulated proteins; including GFAP, HOMER1 and glutamatergic transmission (vesicular transporter 1, VGLUT1)...
  31. Mu X, Wang H, Cheng X, Yang L, Sun X, Qu H, et al. Inhibition of Nkcc1 promotes axonal growth and motor recovery in ischemic rats. Neuroscience. 2017;365:83-93 pubmed publisher
    ..Nogo-A, NKCC1, KCC2 and BDNF in the perilesional cortex and BDA, PSD-95 and vGlut1 in the denervated spinal cord were measured by immunohistochemistry and/or Western blot...
  32. Olivero G, Grilli M, Vergassola M, Bonfiglio T, Padolecchia C, Garrone B, et al. 5-HT2A-mGlu2/3 receptor complex in rat spinal cord glutamatergic nerve endings: A 5-HT2A to mGlu2/3 signalling to amplify presynaptic mechanism of auto-control of glutamate exocytosis. Neuropharmacology. 2018;133:429-439 pubmed publisher
    ..and confocal microscopy highlighted the presence of mGlu2/3 and 5-HT2A receptor proteins in spinal cord VGLUT1 positive synaptosomes, where mGlu2/3 and 5-HT2A receptor immunoreactivities largely colocalize...
  33. David C, Frias E, Szu J, Vieira P, Hubbard J, Lovelace J, et al. GLT-1-Dependent Disruption of CNS Glutamate Homeostasis and Neuronal Function by the Protozoan Parasite Toxoplasma gondii. PLoS Pathog. 2016;12:e1005643 pubmed publisher
    ..dysregulation, analysis of neurons reveal changes in morphology including a reduction in dendritic spines, VGlut1 and NeuN immunoreactivity...
  34. Sun Y, Cheng X, Wang H, Mu X, Liang Y, Luo Y, et al. dl-3-n-butylphthalide promotes neuroplasticity and motor recovery in stroke rats. Behav Brain Res. 2017;329:67-74 pubmed publisher
    ..The expressions of Nogo-A, Nogo-R, Rho-A, and ROCK in the perilesional cortex, the expressions of BDA, PSD-95, and vGlut1 in the denervated spinal cord, 5-bromo-20-deoxyuridine (BrdU)/DCX-positive cells in the subventricular zone (SVZ) ..
  35. Guan L, Chen Y, Zhu H, Chen J, Jiang H. [Study on the induced differentiation of induced pluripotent stem cells into cochlear hair cell-like cells and spiral ganglion neuron-like cells in vitro]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014;49:680-6 pubmed
    ..Calretinin, Espin) and Spiral ganglion neuron markers [Nestin, Neurofilament-M, β-III Tubulin, Vesicular glutamate transporter 1(VGluT1)] were detected by immunocytochemical analysis...
  36. Herring B, Silm K, Edwards R, Nicoll R. Is Aspartate an Excitatory Neurotransmitter?. J Neurosci. 2015;35:10168-71 pubmed publisher
    ..Using a mouse that lacks the glutamate-selective vesicular transporter VGLUT1, we find that glutamate alone fully accounts for the activation of NMDA receptors at excitatory synapses in the ..
  37. Clarkson C, Antunes F, Rubio M. Conductive Hearing Loss Has Long-Lasting Structural and Molecular Effects on Presynaptic and Postsynaptic Structures of Auditory Nerve Synapses in the Cochlear Nucleus. J Neurosci. 2016;36:10214-27 pubmed publisher
    ..During earplugging, vGluT1 expression in the presynaptic terminal decreased and synaptic vesicles were smaller...
  38. Kestell G, Anderson R, Clarke J, Haberberger R, Gibbins I. Primary afferent neurons containing calcitonin gene-related peptide but not substance P in forepaw skin, dorsal root ganglia, and spinal cord of mice. J Comp Neurol. 2015;523:2555-69 pubmed publisher
    ..receptor potential vanilloid type 1 (TRPV1), neurofilament 200 (NF200), or vesicular glutamate transporter 2 (VGluT1)...
  39. El Arfani A, Albertini G, Bentea E, Demuyser T, Van Eeckhaut A, Smolders I, et al. Alterations in the motor cortical and striatal glutamatergic system and D-serine levels in the bilateral 6-hydroxydopamine rat model for Parkinson's disease. Neurochem Int. 2015;88:88-96 pubmed publisher
    ..GLT-1 and GLAST, as well as xCT, the specific subunit of system xc(-), and the vesicular glutamate transporters, VGLUT1 and 2 were investigated at two different time points (1 week and 2 weeks) post-lesion...
  40. Chaney S, Mukherjee S, Giddabasappa A, Rueda E, Hamilton W, Johnson J, et al. Increased proliferation of late-born retinal progenitor cells by gestational lead exposure delays rod and bipolar cell differentiation. Mol Vis. 2016;22:1468-1489 pubmed
    ..In addition, confocal studies of proteins associated with functional synapses (e.g., vesicular glutamate transporter 1 [VGluT1], plasma membrane calcium ATPase [PMCA], transient receptor potential channel M1 [TRPM1], ..
  41. Hackett T, Clause A, Takahata T, Hackett N, Polley D. Differential maturation of vesicular glutamate and GABA transporter expression in the mouse auditory forebrain during the first weeks of hearing. Brain Struct Funct. 2016;221:2619-73 pubmed publisher
    ..roles in the developing auditory forebrain, we tracked the expression of the vesicular transporters of glutamate (VGluT1, VGluT2) and GABA (VGAT) in primary auditory cortex (A1) and medial geniculate body (MGB) of developing mice (P7, ..
  42. Rubio M, Nagy J. Connexin36 expression in major centers of the auditory system in the CNS of mouse and rat: Evidence for neurons forming purely electrical synapses and morphologically mixed synapses. Neuroscience. 2015;303:604-29 pubmed publisher
    ..many neuronal somata were heavily innervated by nerve terminals containing vesicular glutamate transporter-1 (vglut1) and Cx36 was frequently localized at these terminals...
  43. Wang Y, Zhou Z, Tan H, Zhu S, Wang Y, Sun Y, et al. Nitrosylation of Vesicular Transporters in Brain of Amyloid Precursor Protein/Presenilin 1 Double Transgenic Mice. J Alzheimers Dis. 2017;55:1683-1692 pubmed publisher
    ..Vesicular acetylcholine transporter (VAChT) and vesicular glutamate transporter 1 (VGLUT1) are important in packaging acetylcholine and glutamate into vesicles, which is an important ..
  44. Zong H, Ma F, Zhang L, Lu H, Gong J, Cai M, et al. Hindlimb spasticity after unilateral motor cortex lesion in rats is reduced by contralateral nerve root transfer. Biosci Rep. 2016;36: pubmed publisher
    ..of gastrocnemius muscle (GM) motoneurons and immunofluorescent staining of vesicle glutamate transporter 1 (VGLUT1) on CTB-labelled motoneurons were used to assess spasticity of the affected hindlimb...
  45. Poirel O, Mella S, Videau C, Ramet L, Davoli M, Herzog E, et al. Moderate decline in select synaptic markers in the prefrontal cortex (BA9) of patients with Alzheimer's disease at various cognitive stages. Sci Rep. 2018;8:938 pubmed publisher
    ..The expression levels of vesicular glutamate transporters (VGLUT1&2), glutamate uptake site (EAAT2), post-synaptic density protein of 95 kD (PSD95), vesicular GABA/glycine ..
  46. Park S, Ko S, Paik S, Rah J, Lee K, Bae Y. Vesicular glutamate transporter 1 (VGLUT1)- and VGLUT2-immunopositive axon terminals on the rat jaw-closing and jaw-opening motoneurons. Brain Struct Funct. 2018;223:2323-2334 pubmed publisher
    ..found that (1) the large majority of VGLUT + boutons on JC and JO motoneurons were VGLUT2+, (2) the density of VGLUT1 + boutons terminating on JC motoneurons was significantly higher than that on JO motoneurons, (3) the density ..
  47. Báez Becerra C, Filipello F, Sandoval Hernández A, Arboleda H, Arboleda G. Liver X Receptor Agonist GW3965 Regulates Synaptic Function upon Amyloid Beta Exposure in Hippocampal Neurons. Neurotox Res. 2018;33:569-579 pubmed publisher
    ..oAβ(1-42) also modulates the expression of pre- (VGlut1, SYT1, SV2A) and post-synaptic (SHANK2, NMDA) proteins, it decreases the expression of PINK1, and increases ROCKII,..
  48. Salomon Zimri S, Glat M, Barhum Y, Luz I, Boehm Cagan A, Liraz O, et al. Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment. J Alzheimers Dis. 2016;53:1443-58 pubmed publisher
    ..namely the accumulation of hyperphosphorylated tau (AT8) and A?42, and reduced levels of the pre-synaptic marker, VGluT1, and of the ApoE receptor, ApoER2...
  49. Afuwape O, Kavalali E. Imaging Synaptic Vesicle Exocytosis-Endocytosis with pH-Sensitive Fluorescent Proteins. Methods Mol Biol. 2016;1474:187-200 pubmed publisher
  50. Zhou M, Liu Z, Yu J, Li S, Tang M, Zeng L, et al. Quantitative Proteomic Analysis Reveals Synaptic Dysfunction in the Amygdala of Rats Susceptible to Chronic Mild Stress. Neuroscience. 2018;376:24-39 pubmed publisher
    ..Immunoblot analysis identified changes in VGluT1, NMDA GluN2A and GluN2B and AMPA GluA1 receptors, and PSD-95, suggesting that CMS perturbs glutamatergic ..
  51. Wang H, Jin Y, Dai J. Biological processes and pathway changes in isoflurane-induced anesthesia revealed by bioinformatics analysis of gene expression profiles. J Anesth. 2015;29:912-9 pubmed publisher
    ..g., Pik3r1 and Pik3r2) in the constructed PPI network. Additionally, Slc17a7 and Camk4 interacted with Syn1, and Pik3r1 interacted with Pik3r2...
  52. Moriyama S, Iharada M, Omote H, Moriyama Y, Hiasa M. Function and expression of a splicing variant of vesicular glutamate transporter 1. Biochim Biophys Acta Biomembr. 2017;1859:931-940 pubmed publisher
    ..VGLUT consists of three isoforms, VGLUT1, VGLUT2, and VGLUT3...
  53. Jazmati D, Neubacher U, Funke K. Neuropeptide Y as a possible homeostatic element for changes in cortical excitability induced by repetitive transcranial magnetic stimulation. Brain Stimul. 2018;11:797-805 pubmed publisher
    ..Analysis of cortical expression of PV, NPY and vesicular glutamate transporter type 1 (vGluT1) by immunohistochemical means at the level of cell counts, mean neuropil expression and single cell pre-/..
  54. Salatino J, Winter B, Drazin M, Purcell E. Functional remodeling of subtype-specific markers surrounding implanted neuroprostheses. J Neurophysiol. 2017;118:194-202 pubmed publisher
    ..of both excitatory and inhibitory markers of neurotransmission (vesicular glutamate and GABA transporters, VGLUT1 and VGAT, respectively) surrounding single-shank Michigan-style microelectrode arrays implanted in the motor ..
  55. Wang H, Yu G, Wang Z, Yi S, Su R, Gong Z. Changes in VGLUT1 and VGLUT2 expression in rat dorsal root ganglia and spinal cord following spared nerve injury. Neurochem Int. 2016;99:9-15 pubmed publisher
    ..Spared nerve injury (SNI) induced mechanical allodynia from postoperative day 1 to at least day 14. Expression of VGLUT1 and VGLUT2 in dorsal root ganglia and spinal cord was examined by western blot analyses on different postoperative ..
  56. McKillop W, York E, Rubinger L, Liu T, Ossowski N, Xu K, et al. Conditional Sox9 ablation improves locomotor recovery after spinal cord injury by increasing reactive sprouting. Exp Neurol. 2016;283:1-15 pubmed publisher
    ..knock out mice as indicated by increased levels of the presynaptic markers synaptophysin and vesicular glutamate transporter 1 (VGLUT1) compared to controls...
  57. Chung D, Wills Z, Fish K, Lewis D. Developmental pruning of excitatory synaptic inputs to parvalbumin interneurons in monkey prefrontal cortex. Proc Natl Acad Sci U S A. 2017;114:E629-E637 pubmed publisher
    ..The density of excitatory synapses, defined by overlapping vesicular glutamate transporter 1-positive (VGlut1+) and postsynaptic density 95-positive (PSD95+) puncta, on PV interneurons was ..
  58. Thorajak P, Pannangrong W, Welbat J, Chaijaroonkhanarak W, Sripanidkulchai K, Sripanidkulchai B. Effects of Aged Garlic Extract on Cholinergic, Glutamatergic and GABAergic Systems with Regard to Cognitive Impairment in Aβ-Induced Rats. Nutrients. 2017;9: pubmed publisher
    ..The rats were then euthanized to investigate any changes to the cholinergic neurons, vesicular glutamate transporter 1 and 2 proteins (VGLUT1 and VGLUT2), and glutamate decarboxylase (GAD) in the hippocampus...
  59. Helboe L, Egebjerg J, de Jong I. Distribution of serotonin receptor 5-HT6 mRNA in rat neuronal subpopulations: A double in situ hybridization study. Neuroscience. 2015;310:442-54 pubmed publisher
    ..was moderately expressed in the hippocampus and throughout cortical regions in glutamatergic neurons coexpressing vGluT1. A subset of GAD67-positive GABAergic interneurons (approximately 15%) expressed 5-HT6R mRNA in the cortex and ..
  60. Lin H, Magrane J, Clark E, Halawani S, Warren N, Rattelle A, et al. Early VGLUT1-specific parallel fiber synaptic deficits and dysregulated cerebellar circuit in the KIKO mouse model of Friedreich ataxia. Dis Model Mech. 2017;10:1529-1538 pubmed publisher
    ..Here, we report early cerebellar VGLUT1 (SLC17A7)-specific parallel fiber (PF) synaptic deficits and dysregulated cerebellar circuit in the frataxin knock-in/..
  61. Li J, Zhao Y, Wang H, Wang X, Su Y, Si T. Long-term effects of neonatal exposure to MK-801 on recognition memory and excitatory-inhibitory balance in rat hippocampus. Neuroscience. 2015;308:134-43 pubmed publisher
    ..interneurons and presynaptic markers for excitatory and inhibitory neurons, vesicular glutamate transporter-1 (VGLUT1) and vesicular GABA transporter (VGAT) were examined in the hippocampus to reflect the E/I balance...
  62. Mancic B, Stevanovic I, Ilic T, Djuric A, Stojanovic I, Milanovic S, et al. Transcranial theta-burst stimulation alters GLT-1 and vGluT1 expression in rat cerebellar cortex. Neurochem Int. 2016;100:120-127 pubmed publisher
    ..theta-burst stimulation (iTBS; cTBS) on the expression of vesicular and plasmatic glutamate transporters 1 (vGluT1 and GLT-1), glial fibrillary acidic protein (GFAP) and influence on oxidative status in rats cerebellar tissue and ..
  63. Kelley K, Ben Haim L, Schirmer L, Tyzack G, Tolman M, Miller J, et al. Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength. Neuron. 2018;98:306-319.e7 pubmed publisher
    ..1 (a.k.a. Kcnj10) around MNs in a VGLUT1-dependent manner. Loss of astrocyte-encoded Kir4...
  64. Brancato A, Bregman D, Ahn H, Pfau M, Menard C, Cannizzaro C, et al. Sub-chronic variable stress induces sex-specific effects on glutamatergic synapses in the nucleus accumbens. Neuroscience. 2017;350:180-189 pubmed publisher
    ..In a separate group of animals, immunofluorescence staining was performed for vesicular glutamate transporter 1 (VGLUT1) and vesicular glutamate transporter 2 (VGLUT2), in order to label cortical and subcortical ..
  65. Santana N, Artigas F. Expression of Serotonin2C Receptors in Pyramidal and GABAergic Neurons of Rat Prefrontal Cortex: A Comparison with Striatum. Cereb Cortex. 2017;27:3125-3139 pubmed publisher
    ..In PFC, 5-HT2C-R are expressed in pyramidal (VGLUT1-positive) and GABAergic (GAD-positive) neurons, including parvalbumin-positive neurons...
  66. Guillaud L, Dimitrov D, Takahashi T. Presynaptic morphology and vesicular composition determine vesicle dynamics in mouse central synapses. elife. 2017;6: pubmed publisher
    ..At the molecular level, SVs over-expressing vesicular glutamate transporter 1 (VGLUT1) showed higher mobility than VGLUT2-expressing SVs...
  67. Iskhakova L, Smith Y. mGluR4-containing corticostriatal terminals: synaptic interactions with direct and indirect pathway neurons in mice. Brain Struct Funct. 2016;221:4589-4599 pubmed
    ..e. forming asymmetric synapses) express mGluR4 in the mouse striatum. Using vGluT1 as a presynaptic marker of glutamatergic corticostriatal boutons, our findings indicate: (1) all striatal mGluR4-..
  68. Chung D, Fish K, Lewis D. Pathological Basis for Deficient Excitatory Drive to Cortical Parvalbumin Interneurons in Schizophrenia. Am J Psychiatry. 2016;173:1131-1139 pubmed
    ..e., the overlap of vesicular glutamate transporter 1-positive [VGlut1+] puncta and postsynaptic density protein 95-positive [PSD95+] puncta) per surface ..
  69. Madura S, McDevitt J, Tierney R, Mansell J, Hayes D, Gaughan J, et al. Genetic variation in SLC17A7 promoter associated with response to sport-related concussions. Brain Inj. 2016;30:908-13 pubmed publisher
    To determine the association of the single nucleotide polymorphism (SNP) rs74174284 within SLC17A7 promoter with concussion severity or duration. A between-subjects design was utilized...
  70. Takahashi K, Ohsawa I, Shirasawa T, Takahashi M. Early-onset motor impairment and increased accumulation of phosphorylated ?-synuclein in the motor cortex of normal aging mice are ameliorated by coenzyme Q. Exp Gerontol. 2016;81:65-75 pubmed publisher
    ..synuclein (?-syn) phosphorylated at serine129 (Ser129) significantly increased, and the level of vesicular glutamate transporter 1 (VGluT1) decreased compared with that in the young mouse brain...
  71. Harper C, Mancini G, van Slegtenhorst M, Cousin M. Altered synaptobrevin-II trafficking in neurons expressing a synaptophysin mutation associated with a severe neurodevelopmental disorder. Neurobiol Dis. 2017;108:298-306 pubmed publisher
    ..effect on SV endocytosis, which was confirmed when retrieval of a different SV cargo (the glutamate transporter vGLUT1) was examined...
  72. Li H, Santos M, Park C, Dobry Y, Voglmaier S. VGLUT2 Trafficking Is Differentially Regulated by Adaptor Proteins AP-1 and AP-3. Front Cell Neurosci. 2017;11:324 pubmed publisher
    ..The two principal isoforms, VGLUT1 and 2, exhibit a complementary pattern of expression in adult brain that broadly distinguishes cortical (VGLUT1) ..
  73. Shen Y, Liao D, Chen J, Wang Y, Lai I, Liou Y, et al. Resequencing and association study of vesicular glutamate transporter 1 gene (VGLUT1) with schizophrenia. Schizophr Res. 2009;115:254-60 pubmed publisher
    ..Abnormal VGLUT1 expression has been linked to schizophrenia in postmortem brain studies...
  74. Wan Q, Tang J, Han Y, Wang D. Co-expression modules construction by WGCNA and identify potential prognostic markers of uveal melanoma. Exp Eye Res. 2018;166:13-20 pubmed publisher
    ..Additionally, identified the hug gene (top connectivity with other genes) in each module. The hub gene SLC17A7, NTRK2, ABTB1 and ADPRHL1 might play a vital role in recurrence of uveal melanoma...
  75. Vinatier J, Herzog E, Plamont M, Wojcik S, Schmidt A, Brose N, et al. Interaction between the vesicular glutamate transporter type 1 and endophilin A1, a protein essential for endocytosis. J Neurochem. 2006;97:1111-25 pubmed
    ..The three vesicular glutamate transporters (VGLUT1, -2 and -3) are highly conserved proteins that display similar bioenergetic and pharmacological properties but are ..
  76. Richter K, Schmutz I, Darna M, Zander J, Chavan R, Albrecht U, et al. VGLUT1 Binding to Endophilin or Intersectin1 and Dynamin Phosphorylation in a Diurnal Context. Neuroscience. 2018;371:29-37 pubmed publisher
    ..Here we aimed to identify whether the diurnal switches of VGLUT1 parallels interactions with or modification of endocytic proteins...
  77. Alonso Nanclares L, de Felipe J. Vesicular glutamate transporter 1 immunostaining in the normal and epileptic human cerebral cortex. Neuroscience. 2005;134:59-68 pubmed
    ..The vesicular glutamate transporter 1 is found in the majority of axon terminals that form asymmetrical (excitatory) synapses in the rat ..
  78. Patriarchi T, Amabile S, Frullanti E, Landucci E, Lo Rizzo C, Ariani F, et al. Imbalance of excitatory/inhibitory synaptic protein expression in iPSC-derived neurons from FOXG1(+/-) patients and in foxg1(+/-) mice. Eur J Hum Genet. 2016;24:871-80 pubmed publisher
    ..markers (GAD67 and GABA AR-α1) were increased, whereas the levels of a number of excitatory synaptic markers (VGLUT1, GluA1, GluN1 and PSD-95) were decreased...
  79. Rodriguez Perdigon M, Tordera R, Gil Bea F, Gerenu G, Ramirez M, Solas M. Down-regulation of glutamatergic terminals (VGLUT1) driven by Aβ in Alzheimer's disease. Hippocampus. 2016;26:1303-12 pubmed publisher
    ..The present study shows that Aβ caused a loss of glutamatergic terminals, measured by VGLUT1 protein levels, in Tg2576 primary cell cultures, Tg2576 mice and AD patient brains, and also when Aβ was added ..
  80. Schenck S, Kunz L, Sahlender D, Pardon E, Geertsma E, Savtchouk I, et al. Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport. Biochemistry. 2017;56:3962-3971 pubmed publisher
    ..To overcome this shortage, we generated nanobodies (Nbs) by immunization of a llama with purified rat VGLUT1 and subsequent selection of binders from a phage display library...
  81. Santolini I, Celli R, Cannella M, Imbriglio T, Guiducci M, Parisi P, et al. Alterations in the ?2 ? ligand, thrombospondin-1, in a rat model of spontaneous absence epilepsy and in patients with idiopathic/genetic generalized epilepsies. Epilepsia. 2017;58:1993-2001 pubmed publisher
    ..sub>2 ? subunit, and protein levels of ?2 ?, Rab3A, and the vesicular glutamate transporter, VGLUT1, in the somatosensory cortex and ventrobasal thalamus of presymptomatic and symptomatic WAG/Rij rats and in two ..
  82. Mall E, Herrmann D, Niemann H. Murine pluripotent stem cells with a homozygous knockout of Foxg1 show reduced differentiation towards cortical progenitors in vitro. Stem Cell Res. 2017;25:50-60 pubmed publisher
    ..Real-Time (q) PCR revealed that Foxg1KO mPSCs expressed significantly less mRNA of Foxg1, Emx1, and VGlut1 compared to Foxg1WT controls, indicating reduced differentiation towards dorsal telencephalic ..
  83. Uezato A, Meador Woodruff J, McCullumsmith R. Vesicular glutamate transporter mRNA expression in the medial temporal lobe in major depressive disorder, bipolar disorder, and schizophrenia. Bipolar Disord. 2009;11:711-25 pubmed publisher
    ..We found decreased VGLUT1 mRNA expression in both MDD and BD in the entorhinal cortex (ERC), decreased VGLUT2 mRNA expression in MDD in the ..
  84. Höflich K, Beyer C, Clarner T, Schmitz C, Nyamoya S, Kipp M, et al. Acute axonal damage in three different murine models of multiple sclerosis: A comparative approach. Brain Res. 2016;1650:125-133 pubmed publisher
    ..Moreover, we detected increased immunoreactivity of the pre-synaptic protein vesicular glutamate transporter 1 (VGluT1) in demyelinated foci...
  85. Horváth H, Fazekas C, Balazsfi D, Jain S, Haller J, Zelena D. Contribution of Vesicular Glutamate Transporters to Stress Response and Related Psychopathologies: Studies in VGluT3 Knockout Mice. Cell Mol Neurobiol. 2018;38:37-52 pubmed publisher
    ..levels of these axes, but little is known about the contribution of different vesicular glutamate transporters (VGluT1-3) characterizing the glutamatergic neurons...
  86. Lin B, Lee H, Yoon J, Madan A, Wayner E, Tonning S, et al. Global analysis of H3K4me3 and H3K27me3 profiles in glioblastoma stem cells and identification of SLC17A7 as a bivalent tumor suppressor gene. Oncotarget. 2015;6:5369-81 pubmed
    ..Finally, we identified SLC17A7 as a bivalent tumor suppressor gene in GBM, as it is down-regulated at both the protein and RNA levels in GBM ..
  87. Rodriguez Perdigon M, Solas M, Ramirez M. JNK: A Putative Link Between Insulin Signaling and VGLUT1 in Alzheimer's Disease. J Alzheimers Dis. 2016;50:963-7 pubmed publisher
    ..In postmortem cortical tissues, pJNK levels were increased, while insulin signaling and the expression of VGLUT1 were decreased. A significant correlation was found between reduced expression of insulin receptor and VGLUT1...
  88. Begum A, Aguilar J, Elias L, Hong Y. Silver nanoparticles exhibit coating and dose-dependent neurotoxicity in glutamatergic neurons derived from human embryonic stem cells. Neurotoxicology. 2016;57:45-53 pubmed publisher
    ..the production of reactive oxygen species and Ca2+ influxes; reduced the expression of MAP2, PSD95, vGlut1 and NMDA receptor proteins at concentrations as low as 0.1?g/ml...
  89. Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, et al. Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter. J Neurochem. 2000;74:2622-5 pubmed
    ..and 92% similarity to the human brain-specific Na(+)-dependent inorganic phosphate (Na(+)/P(i)) cotransporter (BNPI), which is localized exclusively to neuron-rich regions...
  90. Myers B, McKlveen J, Morano R, Ulrich Lai Y, Solomon M, Wilson S, et al. Vesicular Glutamate Transporter 1 Knockdown in Infralimbic Prefrontal Cortex Augments Neuroendocrine Responses to Chronic Stress in Male Rats. Endocrinology. 2017;158:3579-3591 pubmed publisher
    ..b>vGluT1 is responsible for presynaptic vesicular glutamate packaging in cortical neurons, and knockdown reduces the amount ..
  91. Muñoz Cobo I, Belloch F, Diaz Perdigon T, Puerta E, Tordera R. SIRT2 inhibition reverses anhedonia in the VGLUT1+/- depression model. Behav Brain Res. 2017;335:128-131 pubmed publisher
    ..Specifically, mice heterozygous for the vesicular glutamate transporter 1 (VGLUT1+/-) were used...
  92. Kozuka T, Chaya T, Tamalu F, Shimada M, Fujimaki Aoba K, Kuwahara R, et al. The TRPM1 Channel Is Required for Development of the Rod ON Bipolar Cell-AII Amacrine Cell Pathway in the Retinal Circuit. J Neurosci. 2017;37:9889-9900 pubmed publisher
    ..transmission due to loss of the ON bipolar glutamate receptor mGluR6 or the photoreceptor glutamate transporter VGluT1. In addition, TRPM1 deficiency led to the reduction of total dendritic length, branch numbers, and cell ..