SLC17A6

Summary

Gene Symbol: SLC17A6
Description: solute carrier family 17 member 6
Alias: DNPI, VGLUT2, vesicular glutamate transporter 2, differentiation-associated BNPI, differentiation-associated Na(+)-dependent inorganic phosphate cotransporter, differentiation-associated Na-dependent inorganic phosphate cotransporter, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6, solute carrier family 17 (vesicular glutamate transporter), member 6
Species: human
Products:     SLC17A6

Top Publications

  1. Canet Pons J, Schubert R, Duecker R, Schrewe R, Wölke S, Kieslich M, et al. Ataxia telangiectasia alters the ApoB and reelin pathway. Neurogenetics. 2018;19:237-255 pubmed publisher
    ..Concomitant dysregulations were found for Vglut2/Sema7a as climbing fiber markers, glutamate receptors like Grin2b, and calcium homeostasis factors (Atp2b2, Calb1, ..
  2. Mongredien R, Erdozain A, Dumas S, Cutando L, Del Moral A, Puighermanal E, et al. Cartography of hevin-expressing cells in the adult brain reveals prominent expression in astrocytes and parvalbumin neurons. Brain Struct Funct. 2019;: pubmed publisher
    ..subsets of glutamatergic neurons, identified by the expression of the vesicular glutamate transporters VGLUT1 and VGLUT2; and (3) the majority of cholinergic neurons from motor nuclei...
  3. Angioni L, Cocco C, Ferri G, Argiolas A, Melis M, Sanna F. Involvement of nigral oxytocin in locomotor activity: A behavioral, immunohistochemical and lesion study in male rats. Horm Behav. 2016;83:23-38 pubmed publisher
    ..g., nigrostriatal dopaminergic neurons) and for vesicular glutamate transporters VGluT1, VGluT2 and VGluT3 (e.g., glutamatergic neurons), but not for glutamic acid decarboxylase (e.g...
  4. Shakya M, Shrestha P, Briski K. Hindbrain 5'-Adenosine Monophosphate-activated Protein Kinase Mediates Short-term Food Deprivation Inhibition of the Gonadotropin-releasing Hormone-Luteinizing Hormone Axis: Role of Nitric Oxide. Neuroscience. 2018;383:46-59 pubmed publisher
    ..3-morpholinosydnonimine (SIN-1) reversed inhibitory GnRH and LH responses to FD in high-E rats, and normalized rPO Vglut2, anteroventral periventricular KiSS1, and dorsomedial hypothalamic RFRP-3 mRNA and/or protein profiles...
  5. Kim B, Silverman S, Liu Y, Wordinger R, Pang I, Clark A. In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells. Mol Neurodegener. 2016;11:30 pubmed publisher
    ..Volumetric measurement of the superior colliculus (SC) as well as VGLUT2 and PSD95 expression were studied...
  6. You S, Hellström M, Pollett M, LeVaillant C, Moses C, Rigby P, et al. Large-scale reconstitution of a retina-to-brain pathway in adult rats using gene therapy and bridging grafts: An anatomical and behavioral analysis. Exp Neurol. 2016;279:197-211 pubmed publisher
    ..were seen in superficial but not deep SC layers and many terminals were immunopositive for presynaptic proteins vGlut2 and SV2...
  7. Suthakar K, Ryugo D. Descending projections from the inferior colliculus to medial olivocochlear efferents: Mice with normal hearing, early onset hearing loss, and congenital deafness. Hear Res. 2017;343:34-49 pubmed publisher
    ..round synaptic vesicles, exhibit asymmetric membrane specializations, and are co-labelled with antibodies against VGlut2, a glutamate transporter...
  8. de Kloet A, Wang L, Ludin J, Smith J, Pioquinto D, Hiller H, et al. Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system. Brain Struct Funct. 2016;221:891-912 pubmed publisher
    ..These studies demonstrate that central AT2R are positioned to regulate blood pressure, metabolism, and stress responses. ..
  9. McCarthy C, Tomasella E, Malet M, Seroogy K, Hökfelt T, Villar M, et al. Axotomy of tributaries of the pelvic and pudendal nerves induces changes in the neurochemistry of mouse dorsal root ganglion neurons and the spinal cord. Brain Struct Funct. 2016;221:1985-2004 pubmed publisher
    ..ATF3 in many L6-S1 DRG NPs, and parallel significant downregulations in the percentage of CGRP-, TRPV1-, TH- and VGLUT2-immunoreactive (IR) DRG NPs, as compared to their expression in uninjured DRGs (contralateral L6-S1-AXO; sham mice)..

More Information

Publications118 found, 100 shown here

  1. Manohar S, Dahar K, Adler H, Dalian D, Salvi R. Noise-induced hearing loss: Neuropathic pain via Ntrk1 signaling. Mol Cell Neurosci. 2016;75:101-12 pubmed publisher
    ..Expression levels of mRNA of Slc17a6 and Gabrg3, involved in excitation and inhibition respectively, were significantly increased at 28days post-..
  2. Blacktop J, Sorg B. Perineuronal nets in the lateral hypothalamus area regulate cue-induced reinstatement of cocaine-seeking behavior. Neuropsychopharmacology. 2019;44:850-858 pubmed publisher
    ..LHAad neurons co-localized mainly with parvalbumin (PV+) and GABA. Predominant co-localization of WFA with VGLUT2 and GABA but not with GAD65/67 or glutamate indicates that the PNN/ECM-rich LHAad is predominantly GABAergic and ..
  3. Nothwang H. Evolution of mammalian sound localization circuits: A developmental perspective. Prog Neurobiol. 2016;141:1-24 pubmed publisher
    ..I will argue that the major VGlut2(+) excitatory projection neurons of sound localization circuits (dorsal cochlear nucleus (DCN), lateral and medial ..
  4. Brancato A, Bregman D, Ahn H, Pfau M, Menard C, Cannizzaro C, et al. Sub-chronic variable stress induces sex-specific effects on glutamatergic synapses in the nucleus accumbens. Neuroscience. 2017;350:180-189 pubmed publisher
    ..immunofluorescence staining was performed for vesicular glutamate transporter 1 (VGLUT1) and vesicular glutamate transporter 2 (VGLUT2), in order to label cortical and subcortical glutamatergic terminals...
  5. Nakadate K. Developmental changes in the flotillin-1 expression pattern of the rat visual cortex. Neuroscience. 2015;292:101-11 pubmed publisher
    ..protein 2, anti-neurofilament, anti-synaptophysin, anti-vesicular glutamate transporter 1, anti-vesicular glutamate transporter 2, anti-glial fibrillary acidic protein, and flotillin-1 mainly labeled the somata of excitatory ..
  6. Khan S, Yuldasheva N, Batten T, Pickles A, Kellett K, Saha S. Tau pathology and neurochemical changes associated with memory dysfunction in an optimised murine model of global cerebral ischaemia - A potential model for vascular dementia?. Neurochem Int. 2018;118:134-144 pubmed publisher
    ..Brains were processed for Western blotting or immunohistochemistry for glial (GLT1) and vesicular (VGLUT1, VGLUT2) glutamate transporters and paired helical filament (PHF1) tau...
  7. Morin N, Morissette M, Grégoire L, Di Paolo T. mGlu5, Dopamine D2 and Adenosine A2A Receptors in L-DOPA-induced Dyskinesias. Curr Neuropharmacol. 2016;14:481-93 pubmed
    ..of glutamate activity in the basal ganglia of L-DOPA-induced changes of NMDA, AMPA, mGlu2/3 receptors and VGlut2 transporter...
  8. Tanaka T, Abe H, Kimura M, Onda N, Mizukami S, Yoshida T, et al. Developmental exposure to T-2 toxin reversibly affects postnatal hippocampal neurogenesis and reduces neural stem cells and progenitor cells in mice. Arch Toxicol. 2016;90:2009-24 pubmed publisher
    ..levels of cholinergic and glutamate receptor subunits (Chrna4, Chrnb2 and Gria2) and glutamate transporter (Slc17a6) in the dentate gyrus, suggesting decreased cholinergic signals on hilar GABAergic interneurons innervating type-..
  9. Li X, Han Y, Zhang W, Wang S, Wei Y, Li S, et al. AGRP Neurons Project to the Medial Preoptic Area and Modulate Maternal Nest-Building. J Neurosci. 2019;39:456-471 pubmed publisher
    ..In comparison, chemogenetic inhibition of neurons in the LHA that express vesicular glutamate transporter 2, another hypothalamic neuronal population critical for feeding and innate drives, is ineffective...
  10. Aggarwal S, Tang C, Sing K, Kim H, Millar R, Tello J. Medial Amygdala Kiss1 Neurons Mediate Female Pheromone Stimulation of Luteinizing Hormone in Male Mice. Neuroendocrinology. 2019;108:172-189 pubmed publisher
    ..we identified the proportion of MeAKiss neurons that express markers for GABAergic (Vgat) and glutamatergic (Vglut2) neurotransmission...
  11. Yokota S, Kaur S, Vanderhorst V, Saper C, Chamberlin N. Respiratory-related outputs of glutamatergic, hypercapnia-responsive parabrachial neurons in mice. J Comp Neurol. 2015;523:907-20 pubmed publisher
    ..To test this hypothesis, we combined c-Fos immunohistochemistry with in situ hybridization for vGluT2 or GAD67 or with retrograde tracing from the ventrolateral medullary region that contains phrenic premotor neurons,..
  12. Wang Y, Zhou Z, Leylek T, Tan H, Sun Y, Parkinson F, et al. Protein cysteine S-nitrosylation inhibits vesicular uptake of neurotransmitters. Neuroscience. 2015;311:374-81 pubmed publisher
    ..VAChT) is responsible for the uptake of acetylcholine, while vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2) are responsible for the uptake of glutamate...
  13. Cui L, Pierce D, Light K, Melchert R, Fu Q, Kumar K, et al. Sublethal total body irradiation leads to early cerebellar damage and oxidative stress. Curr Neurovasc Res. 2010;7:125-35 pubmed
    ..growth factor receptor 2 (VEGF-R2), CD45, calbindin D-28k (CB- 28) and vesicular glutamate transport-2 (VGLUT2) in cerebellar folia II to IV...
  14. Ruiz Perera L, Schneider L, Windmöller B, Müller J, Greiner J, Kaltschmidt C, et al. NF-κB p65 directs sex-specific neuroprotection in human neurons. Sci Rep. 2018;8:16012 pubmed publisher
    ..We successfully differentiated ITSCs into MAP-2+/NF200+/Synaptophysin+/vGlut2+-glutamatergic neurons in vitro and ex vivo and validated their functionality...
  15. Strand J, Stinson C, Bellinger L, Peng Y, Kramer P. Gi protein functions in thalamic neurons to decrease orofacial nociceptive response. Brain Res. 2018;1694:63-72 pubmed publisher
    ..Immunostaining of the VP for glutamate vesicular transporter (VGLUT2) and gamma-aminobutyric acid vesicular transporter (VGAT) indicated a majority of the virally transfected cells ..
  16. Fyk Kolodziej B, Shimano T, Gafoor D, Mirza N, Griffith R, Gong T, et al. Dopamine in the auditory brainstem and midbrain: co-localization with amino acid neurotransmitters and gene expression following cochlear trauma. Front Neuroanat. 2015;9:88 pubmed publisher
    ..However, in the IC, DA receptor 1 (DRDA1), vesicular glutamate transporters 2 and 3 (VGLUT2, VGLUT3), GABAtp and GAD67 were reduced in expression both at the 3 days and 2 months time points...
  17. Gutierrez Mecinas M, Watanabe M, Todd A. Expression of gastrin-releasing peptide by excitatory interneurons in the mouse superficial dorsal horn. Mol Pain. 2014;10:79 pubmed publisher
    ..EGFP+ cells in the GRP-EGFP mouse did not express Pax2, and their axons contained the vesicular glutamate transporter 2 (VGLUT2), indicating that they are excitatory interneurons...
  18. Tagliaferro P, Morales M. Synapses between corticotropin-releasing factor-containing axon terminals and dopaminergic neurons in the ventral tegmental area are predominantly glutamatergic. J Comp Neurol. 2008;506:616-26 pubmed
    ..are glutamatergic, insofar as the CRF-immunolabeled axon terminals in these synapses coexpressed the vesicular glutamate transporter 2, and that the majority of CRF symmetric synapses are GABAergic, insofar as the CRF-immunolabeled ..
  19. Fan L, Chen Z, Fu W, Xu N, Liu J, Lu A, et al. Soluble N-ethylmaleimide-sensitive Factor Attachment Receptor (SNARE) Protein Involved in the Remission of Depression by Acupuncture in Rats. J Acupunct Meridian Stud. 2016;9:242-249 pubmed publisher
    ..blots and reverse transcription polymerase chain reactions were employed to detect protein and mRNA expressions of VGLUT2, SNAP25, VAMP1, VAMP2, VAMP7, and syntaxin1; no obvious differences among the riluzole+BTX-A, acupuncture+BTX-A ..
  20. Talman W, Dragon D, Lin L. Reduced responses to glutamate receptor agonists follow loss of astrocytes and astroglial glutamate markers in the nucleus tractus solitarii. Physiol Rep. 2017;5: pubmed publisher
    ..Also we quantified changes in immunoreactivity (IR) for EAAT2, EAAC1, and VGluT2 in NTS after SAP and SAP conjugates...
  21. Xiao C, Pinol R, Carlin J, Li C, Deng C, Gavrilova O, et al. Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism. Mol Metab. 2017;6:1540-1550 pubmed publisher
    ..We then studied four groups of mice with Brs3 selectively inactivated or re-expressed in cells expressing Vglut2-Cre or Vgat-Cre...
  22. Xu H, Iyer N, Huettner J, Sakiyama Elbert S. A puromycin selectable cell line for the enrichment of mouse embryonic stem cell-derived V3 interneurons. Stem Cell Res Ther. 2015;6:220 pubmed publisher
    ..The selected population expressed the neuronal marker β-III tubulin and the glutamatergic neuron marker VGluT2. The selected V3 INs also exhibited appropriate functional maturation, as assessed by electrophysiology, and ..
  23. Qu X, Wang H, Liu R. Recent insights into biological functions of mammalian bombesin-like peptides and their receptors. Curr Opin Endocrinol Diabetes Obes. 2018;25:36-41 pubmed publisher
    ..in the dorsal lamina without projections outside the spinal cord and mediate itch signals via vesicular glutamate transporter 2. Those neurons receive itch signals and make synapses with the parabrachial nucleus projecting ..
  24. Fleischer W, Theiss S, Schnitzler A, Sergeeva O. Glutamine triggers long-lasting increase in striatal network activity in vitro. Exp Neurol. 2017;290:41-52 pubmed publisher
    ..Real-time PCR and immunocytochemistry demonstrated the presence of vesicular glutamate transporters (VGLUT1 and VGLUT2) necessary for synaptic glutamate release in striatal neurons...
  25. Chachlaki K, Malone S, Qualls Creekmore E, Hrabovszky E, Munzberg H, Giacobini P, et al. Phenotyping of nNOS neurons in the postnatal and adult female mouse hypothalamus. J Comp Neurol. 2017;525:3177-3189 pubmed publisher
    ..Notably, almost all ER?-immunoreactive cells of the OV/MEPO also expressed nNOS. Moreover, the use of EYFPVglut2 , EYFPVgat , and GFPGad67 transgenic mouse lines revealed that, like GnRH neurons, ..
  26. Marchese M, Valvo G, Moro F, Sicca F, Santorelli F. Targeted Gene Resequencing (Astrochip) to Explore the Tripartite Synapse in Autism-Epilepsy Phenotype with Macrocephaly. Neuromolecular Med. 2016;18:69-80 pubmed publisher
    ..MAEP/AEP subgroups, belong to proteins specifically involved in glutamate transport and metabolism (namely, SLC17A6, GRM8, and GLUL), as well as in potassium conductance (KCNN3)...
  27. Kestell G, Anderson R, Clarke J, Haberberger R, Gibbins I. Primary afferent neurons containing calcitonin gene-related peptide but not substance P in forepaw skin, dorsal root ganglia, and spinal cord of mice. J Comp Neurol. 2015;523:2555-69 pubmed publisher
    ..subpopulations transient receptor potential vanilloid type 1 (TRPV1), neurofilament 200 (NF200), or vesicular glutamate transporter 2 (VGluT1)...
  28. Aceves Buendia J, Tiroshi L, Chiu W, Goldberg J. Selective remodeling of glutamatergic transmission to striatal cholinergic interneurons after dopamine depletion. Eur J Neurosci. 2019;49:824-833 pubmed publisher
    ..this thalamostriatal projection, we virally transfected with Cre-dependent channelrhodopsin-2 (ChR2) the PfN of Vglut2-Cre mice that were dopamine-depleted with 6-hydroxydopamine (6-OHDA)...
  29. Holstein G, Friedrich V, Martinelli G. Glutamate and GABA in Vestibulo-Sympathetic Pathway Neurons. Front Neuroanat. 2016;10:7 pubmed publisher
    ..Only the GABAergic VSR pathway neurons showed a target preference, projecting predominantly to CVLM. These data provide the first demonstration of two disparate chemoanatomic VSR pathways. ..
  30. Dumalska I, Wu M, Morozova E, Liu R, van den Pol A, Alreja M. Excitatory effects of the puberty-initiating peptide kisspeptin and group I metabotropic glutamate receptor agonists differentiate two distinct subpopulations of gonadotropin-releasing hormone neurons. J Neurosci. 2008;28:8003-13 pubmed publisher
    ..The first subpopulation is comprised of septal GnRH neurons that colocalize vesicular glutamate transporter 2 and green fluorescent protein and is insensitive to metabotropic glutamate receptor agonists, but is ..
  31. Fujimoto H, Konno K, Watanabe M, Jinno S. Late postnatal shifts of parvalbumin and nitric oxide synthase expression within the GABAergic and glutamatergic phenotypes of inferior colliculus neurons. J Comp Neurol. 2017;525:868-884 pubmed publisher
    ..Fluorescent in situ hybridization for vesicular glutamate transporter 2 mRNA indicated that almost all GAD67- IC neurons represented the glutamatergic phenotype...
  32. Lauer S, Lenschow C, Brecht M. Sexually selected size differences and conserved sexual monomorphism of genital cortex. J Comp Neurol. 2017;525:2706-2718 pubmed publisher
    ..5% of somatosensory cortex area in chipmunks to 1.7% in rats. This relative size of the genital protrusion co-varied with relative testicle size, an indicator of sperm competition and sexual selection. ..
  33. Peng S, Wu J, Zhang D, Jiang C, Xie C, Liu T. Contribution of presynaptic HCN channels to excitatory inputs of spinal substantia gelatinosa neurons. Neuroscience. 2017;358:146-157 pubmed publisher
    ..The HCN4 isoform showed the highest level of co-localization with VGLUT2 (23±3%)...
  34. Xiang C, Zhang K, Johnson R, Jacquin M, Chen Z. The transcription factor, Lmx1b, promotes a neuronal glutamate phenotype and suppresses a GABA one in the embryonic trigeminal brainstem complex. Somatosens Mot Res. 2012;29:1-12 pubmed publisher
    ..5. Subsequently, until the day of birth, glutamatergic markers (e.g., VGLUT2) stain significantly fewer PrV neurons, whereas, GABAergic markers (Pax2 and Gad1) stain significantly more PrV ..
  35. Thorajak P, Pannangrong W, Welbat J, Chaijaroonkhanarak W, Sripanidkulchai K, Sripanidkulchai B. Effects of Aged Garlic Extract on Cholinergic, Glutamatergic and GABAergic Systems with Regard to Cognitive Impairment in Aβ-Induced Rats. Nutrients. 2017;9: pubmed publisher
    ..investigate any changes to the cholinergic neurons, vesicular glutamate transporter 1 and 2 proteins (VGLUT1 and VGLUT2), and glutamate decarboxylase (GAD) in the hippocampus...
  36. Murota H, Katayama I. Evolving understanding on the aetiology of thermally provoked itch. Eur J Pain. 2016;20:47-50 pubmed publisher
    ..channel subfamily vanilloid type 1 (TRPV1), the calcitonin gene-related peptide (CGRP) and the vesicular glutamate transporter 2 (VGLUT2), which link noxious heat and itch, contribute to a much better understanding of the ..
  37. Farhan S, Nixon K, Everest M, Edwards T, Long S, Segal D, et al. Identification of a novel synaptic protein, TMTC3, involved in periventricular nodular heterotopia with intellectual disability and epilepsy. Hum Mol Genet. 2017;26:4278-4289 pubmed publisher
    ..TMTC3 did not co-localize with Vglut2, a presynaptic marker for excitatory neurons...
  38. Geerling J, Kim M, Mahoney C, Abbott S, Agostinelli L, Garfield A, et al. Genetic identity of thermosensory relay neurons in the lateral parabrachial nucleus. Am J Physiol Regul Integr Comp Physiol. 2016;310:R41-54 pubmed publisher
    ..all FoxP2+ neurons in these subregions colocalized with green fluorescent protein (GFP) in reporter mice for Vglut2, but not for Vgat...
  39. Hwang H, Zhang E, Park S, Chung W, Lee S, Kim D, et al. TWIK-Related Spinal Cord K⁺ Channel Expression Is Increased in the Spinal Dorsal Horn after Spinal Nerve Ligation. Yonsei Med J. 2015;56:1307-15 pubmed publisher
    ..that immunoreactivity of TRESK was mostly restricted in neuronal cells, and that synapse markers GAD67 and VGlut2 appeared to be associated with TRESK expression...
  40. Farzanehfar P, Horne M, Aumann T. An investigation of gene expression in single cells derived from Nestin-expressing cells in the adult mouse midbrain in vivo. Neurosci Lett. 2017;648:34-40 pubmed publisher
    ..e. NeuN, Gad1, Gad2, vGlut2, TH and/or D2R) and neurogenesis (i.e...
  41. Ji P, Chen L, Gong J, Yuan Y, Li M, Zhao Y, et al. Co-expression of vasoactive intestinal peptide and protein gene product 9.5 surrounding the lumen of human Schlemm's canal. Exp Eye Res. 2018;170:1-7 pubmed publisher
    ..intestinal peptide (VIP), as well as sensory nerve marker calcitonin gene-related peptide (CGRP) and vesicular glutamate transporter 2 (VGLUT2)...
  42. Liu X, Shen Y, Pleasure D, Deng W. The vulnerability of thalamocortical circuitry to hypoxic-ischemic injury in a mouse model of periventricular leukomalacia. BMC Neurosci. 2016;17:2 pubmed publisher
    ..of the thalamocortical circuitry that can be defined by vesicular glutamate transporters 1 and 2 (vGluT1 and vGluT2), both of which are required for glutamatergic synaptic transmission in the central nervous system...
  43. Ito T, Atoji Y. Tectothalamic inhibitory projection neurons in the avian torus semicircularis. J Comp Neurol. 2016;524:2604-22 pubmed publisher
    ..Of these, larger GABA?+?cells were encircled by dense VGLUT2?+?axosomatic terminals...
  44. Butts J, McCreedy D, Martinez Vargas J, Mendoza Camacho F, Hookway T, Gifford C, et al. Differentiation of V2a interneurons from human pluripotent stem cells. Proc Natl Acad Sci U S A. 2017;114:4969-4974 pubmed publisher
    ..Over time, CHX10+ cells expressed neuronal markers [neurofilament, NeuN, and vesicular glutamate transporter 2 (VGlut2)], and cultures exhibited increased action potential frequency...
  45. TIMBIE C, Barbas H. Pathways for Emotions: Specializations in the Amygdalar, Mediodorsal Thalamic, and Posterior Orbitofrontal Network. J Neurosci. 2015;35:11976-87 pubmed publisher
    ..Larger amygdalar neurons projected to MDmc and expressed the vesicular glutamate transporter 2 (VGLUT2), which is found in highly efficient "driver" pathways...
  46. Takahashi N, Nakamuta N, Yamamoto Y. Morphology of P2X3-immunoreactive nerve endings in the rat laryngeal mucosa. Histochem Cell Biol. 2016;145:131-46 pubmed publisher
    ..P2X3-immunoreactive axon terminals were also immunoreactive to vGLUT1, vGLUT2, and vGLUT3...
  47. Billwiller F, Renouard L, Clement O, Fort P, Luppi P. Differential origin of the activation of dorsal and ventral dentate gyrus granule cells during paradoxical (REM) sleep in the rat. Brain Struct Funct. 2017;222:1495-1507 pubmed publisher
    ..are glutamatergic and/or GABAergic, we combined FOS immunostaining with in situ hybridization of vesicular glutamate transporter 2 (vGLUT2, a marker of glutamatergic neurons) or that of the vesicular GABA transporter (vGAT, a ..
  48. Ito T, Inoue K, Takada M. Distribution of glutamatergic, GABAergic, and glycinergic neurons in the auditory pathways of macaque monkeys. Neuroscience. 2015;310:128-51 pubmed publisher
    ..In this study, we examined the overall distribution of cell bodies that expressed mRNAs for VGLUT1, and VGLUT2 (markers for glutamatergic neurons), GAD67 (a marker for GABAergic neurons), and GLYT2 (a marker for glycinergic ..
  49. Fuhrmann F, Justus D, Sosulina L, Kaneko H, Beutel T, Friedrichs D, et al. Locomotion, Theta Oscillations, and the Speed-Correlated Firing of Hippocampal Neurons Are Controlled by a Medial Septal Glutamatergic Circuit. Neuron. 2015;86:1253-64 pubmed publisher
    ..Here we reveal a septo-hippocampal circuit mediated by glutamatergic (VGluT2(+)) neurons that is activated before locomotion onset and that controls the initiation and velocity of locomotion ..
  50. Mingote S, Chuhma N, Kusnoor S, Field B, Deutch A, Rayport S. Functional Connectome Analysis of Dopamine Neuron Glutamatergic Connections in Forebrain Regions. J Neurosci. 2015;35:16259-71 pubmed publisher
    In the ventral tegmental area (VTA), a subpopulation of dopamine neurons express vesicular glutamate transporter 2 and make glutamatergic connections to nucleus accumbens (NAc) and olfactory tubercle (OT) neurons...
  51. Holloway B, Viar K, Stornetta R, Guyenet P. The retrotrapezoid nucleus stimulates breathing by releasing glutamate in adult conscious mice. Eur J Neurosci. 2015;42:2271-82 pubmed publisher
    ..RTN neurons contain vesicular glutamate transporter-2 (Vglut2) transcripts (Slc17a6), and their synaptic boutons are Vglut2-immunoreactive...
  52. Chernigovskaya E, Korotkov A, Nikitina L, Dorofeeva N, Glazova M. The expression and distribution of seizure-related and synaptic proteins in the insular cortex of rats genetically prone to audiogenic seizures. Neurol Res. 2015;37:1108-17 pubmed publisher
    ..Our data demonstrated an increased level of vesicular glutamate transporter VGLUT2 in naïve and seizure-experienced KM rats, while glutamic acid decarboxylases GAD65 and GAD67 levels were ..
  53. Hayashi K, Furuya A, Sakamaki Y, Akagi T, Shinoda Y, Sadakata T, et al. The brain-specific RasGEF very-KIND is required for normal dendritic growth in cerebellar granule cells and proper motor coordination. PLoS ONE. 2017;12:e0173175 pubmed publisher
    ..Immunoreactivity for vGluT2 (a marker for excitatory presynapses of mossy fiber terminals) was increased in the cerebellar glomeruli of KO ..
  54. Mao H, Hamodeh S, Sultan F. Quantitative Comparison Of Vesicular Glutamate Transporters in rat Deep Cerebellar Nuclei. Neuroscience. 2018;376:152-161 pubmed publisher
    ..deep cerebellar nuclei (DCN) were quantitatively analyzed by vesicular glutamate transporter 1 and 2 (vGluT1 and vGluT2) immunolabeling...
  55. Yin W, Sun Z, Mendenhall J, Walker D, Riha P, Bezner K, et al. Expression of Vesicular Glutamate Transporter 2 (vGluT2) on Large Dense-Core Vesicles within GnRH Neuroterminals of Aging Female Rats. PLoS ONE. 2015;10:e0129633 pubmed publisher
    ..GnRH terminals co-express the vesicular glutamate transporter 2 (vGluT2) as a marker of a glutamatergic phenotype...
  56. Zeeh C, Mustari M, Hess B, Horn A. Transmitter inputs to different motoneuron subgroups in the oculomotor and trochlear nucleus in monkey. Front Neuroanat. 2015;9:95 pubmed publisher
    ..SIF and MIF motoneurons of individual eye muscles do not differ numerically in their GABAergic, glycinergic and vGlut2 input, vGlut1 containing terminals densely covered the supraoculomotor area (SOA) targeting MR MIF motoneurons...
  57. Heeringa A, Stefanescu R, Raphael Y, Shore S. Altered vesicular glutamate transporter distributions in the mouse cochlear nucleus following cochlear insult. Neuroscience. 2016;315:114-24 pubmed publisher
    Vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2) have distinct distributions in the cochlear nucleus that correspond to sources of the labeled terminals...
  58. Kim Y, Kim T, McKemy D, Bae Y. Expression of vesicular glutamate transporters in transient receptor potential melastatin 8 (TRPM8)-positive dental afferents in the mouse. Neuroscience. 2015;303:378-88 pubmed publisher
    ..We investigated the coexpression of TRPM8 and vesicular glutamate transporter 1 (VGLUT1) and VGLUT2 in the trigeminal ganglion (TG) and the dental pulp before and after inducing pulpal inflammation...
  59. Vega Zuniga T, Marin G, González Cabrera C, Planitscher E, Hartmann A, Marks V, et al. Microconnectomics of the pretectum and ventral thalamus in the chicken (Gallus gallus). J Comp Neurol. 2016;524:2208-29 pubmed publisher
    ..In situ hybridization revealed that most neurons in the GT express the vesicular glutamate transporter (VGluT2) mRNA, indicating a glutamatergic identity...
  60. Caporali P, Bruno F, Palladino G, Dragotto J, Petrosini L, Mangia F, et al. Developmental delay in motor skill acquisition in Niemann-Pick C1 mice reveals abnormal cerebellar morphogenesis. Acta Neuropathol Commun. 2016;4:94 pubmed publisher
    ..A reduced VGluT2 and GAD65 expression also indicated an overall derangement of the glutamatergic/GABAergic stimulation that PCs ..
  61. Wang T, Miller K. Characterization of glutamatergic neurons in the rat atrial intrinsic cardiac ganglia that project to the cardiac ventricular wall. Neuroscience. 2016;329:134-50 pubmed publisher
    ..with immunohistochemistry using glutamatergic markers: vesicular glutamate transporters 1 and 2 (VGLUT1; VGLUT2), and glutaminase (GLS), the enzyme essential for glutamate production...
  62. Heise C, Schroeder J, Schoen M, Halbedl S, Reim D, Woelfle S, et al. Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus. Front Cell Neurosci. 2016;10:106 pubmed publisher
    ..No costaining was found at VGLUT2-positive contacts indicating that the molecular organization of VGLUT2-associated PSDs diverges from classical ..
  63. Azogu I, Plamondon H. Blockade of TrkB receptors in the nucleus accumbens prior to heterotypic stress alters corticotropin-releasing hormone (CRH), vesicular glutamate transporter 2 (vGluT2) and glucocorticoid receptor (GR) within the mesolimbic pathway. Horm Behav. 2017;90:98-112 pubmed publisher
    ..25μg/0.5μl/min) on anxiety, and expression of Trk-B, corticotropin-releasing hormone (CRH), vesicular glutamate transporter 2 (vGluT2) and glucocorticoid receptor (GR) within the mesolimbic pathway were determined...
  64. Laperchia C, Imperatore R, Azeez I, Del Gallo F, Bertini G, Grassi Zucconi G, et al. The excitatory/inhibitory input to orexin/hypocretin neuron soma undergoes day/night reorganization. Brain Struct Funct. 2017;222:3847-3859 pubmed publisher
    ..The combined total number of glutamatergic (Syn+/VGluT2+) and GABAergic (Syn+/VGAT+) varicosities apposed to OX-A somata was similar ..
  65. Martin C, Navarro V, Simavli S, Vong L, Carroll R, Lowell B, et al. Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone. J Neurosci. 2014;34:6047-56 pubmed publisher
    ..female mouse by selective ablation of the leptin receptor in each neuronal population: Vgat-Cre;Lepr(lox/lox) and Vglut2-Cre;Lepr(lox/lox) mice, respectively...
  66. Wang H, Qi J, Zhang S, Wang H, Morales M. Rewarding Effects of Optical Stimulation of Ventral Tegmental Area Glutamatergic Neurons. J Neurosci. 2015;35:15948-54 pubmed publisher
    ..VTA glutamatergic neurons--expressing vesicular glutamate transporter-2 (VGluT2)--project to limbic and cortical regions, but also excite neighboring dopaminergic neurons...
  67. Yang C, McKenna J, Brown R. Intrinsic membrane properties and cholinergic modulation of mouse basal forebrain glutamatergic neurons in vitro. Neuroscience. 2017;352:249-261 pubmed publisher
    ..Here, we use vesicular glutamate transporter 2 (vGluT2)-tdTomato mice, expressing a red fluorescent protein (tdTomato) in the major group of BF ..
  68. Shen Y, Liao D, Lu C, Chen J, Liou Y, Chen T, et al. Resequencing of the vesicular glutamate transporter 2 gene (VGLUT2) reveals some rare genetic variants that may increase the genetic burden in schizophrenia. Schizophr Res. 2010;121:179-86 pubmed publisher
    ..In mesencephalic dopamine neuron culture, the majority of isolated dopamine neurons express VGLUT2, but not VGLUT1 or 3, have been demonstrated...
  69. Root D, Mejías Aponte C, Qi J, Morales M. Role of glutamatergic projections from ventral tegmental area to lateral habenula in aversive conditioning. J Neurosci. 2014;34:13906-10 pubmed publisher
    ..In addition to these mesohabenular TH-GABAergic neurons, the VTA has many neurons expressing vesicular glutamate transporter 2 (VGluT2) that also project to LHb...
  70. Zhu X, Ward P, English A. Selective Requirement for Maintenance of Synaptic Contacts onto Motoneurons by Target-Derived trkB Receptors. Neural Plast. 2016;2016:2371893 pubmed publisher
    ..of contacts by structures immunoreactive for either of two different vesicular glutamate transporters (VGLUT1 and VGLUT2), the vesicular GABA transporter, or glutamic acid decarboxylase 67 (GAD67) with the somata of motoneurons, was ..
  71. McCollum L, Roberts R. Uncovering the role of the nucleus accumbens in schizophrenia: A postmortem analysis of tyrosine hydroxylase and vesicular glutamate transporters. Schizophr Res. 2015;169:369-373 pubmed publisher
    ..We compared the protein levels of tyrosine hydroxylase (TH) and vesicular glutamate transporters vGLUT1 and vGLUT2 in control (n=7) and schizophrenia (n=13) subjects using Western blot analysis...
  72. Ohgomori T, Yamasaki R, Kira J, Jinno S. Upregulation of Vesicular Glutamate Transporter 2 and STAT3 Activation in the Spinal Cord of Mice Receiving 3,3'-Iminodipropionitrile. Neurotox Res. 2018;33:768-780 pubmed publisher
    ..here we focused on a potential link between phosphorylated STAT3 (pSTAT3, an active form) and vesicular glutamate transporter 2 (VGluT2, a regulator of glutamate storage and release) in IDPN-treated mice and SOD1 G93A ..
  73. Wouterlood F, Aliane V, Boekel A, Hur E, Zaborszky L, Barroso Chinea P, et al. Origin of calretinin-containing, vesicular glutamate transporter 2-coexpressing fiber terminals in the entorhinal cortex of the rat. J Comp Neurol. 2008;506:359-70 pubmed
    ..Some CR fibers contain vesicular glutamate transporter 2 (VGluT2, associated with glutamatergic neurotransmission)...
  74. Han X, He Y, Bi G, Zhang H, Song R, Liu Q, et al. CB1 Receptor Activation on VgluT2-Expressing Glutamatergic Neurons Underlies Δ9-Tetrahydrocannabinol (Δ9-THC)-Induced Aversive Effects in Mice. Sci Rep. 2017;7:12315 pubmed publisher
    ..are found not only on VTA GABAergic neurons, but also on VTA glutamatergic neurons that express vesicular glutamate transporter 2 (VgluT2)...
  75. Miterko L, Sillitoe R. Climbing Fiber Development Is Impaired in Postnatal Car8 wdl Mice. Cerebellum. 2018;17:56-61 pubmed publisher
    ..By immunolabeling CF terminals with VGLUT2, we found evidence of premature CF synapse elimination and delayed translocation from PC somata at postnatal day (..
  76. Murao N, Yokoi N, Honda K, Han G, Hayami T, Gheni G, et al. Essential roles of aspartate aminotransferase 1 and vesicular glutamate transporters in β-cell glutamate signaling for incretin-induced insulin secretion. PLoS ONE. 2017;12:e0187213 pubmed publisher
    ..cytosolic glutamate, and the vesicular glutamate transporters (VGLUT1, VGLUT2, and VGLUT3, gene symbol Slc17a7, Slc17a6, and Slc17a8, respectively), which participate in glutamate transport into secretory vesicles...
  77. Martins L, Seoane Collazo P, CONTRERAS C, González García I, Martínez Sánchez N, González F, et al. A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance. Cell Rep. 2016;16:2231-2242 pubmed publisher
    ..its impact on OX expression and thermogenesis is abolished by the knockdown of glutamate vesicular transporter 2 (VGLUT2), implicating glutamatergic signaling...
  78. Shiraishi A, Muguruma K, Sasai Y. Generation of thalamic neurons from mouse embryonic stem cells. Development. 2017;144:1211-1220 pubmed publisher
    ..mESC thalamic precursors began to express the glutamate transporter vGlut2 and the axon-specific marker VGF, similar to mature projection neurons...
  79. Choudhary A, Somalwar A, Sagarkar S, Rale A, Sakharkar A, Subhedar N, et al. CART neurons in the lateral hypothalamus communicate with the nucleus accumbens shell via glutamatergic neurons in paraventricular thalamic nucleus to modulate reward behavior. Brain Struct Funct. 2018;223:1313-1328 pubmed publisher
    ..a distinct increase in the (a) c-Fos expressing cells and CART fiber terminals, and (b) CART and vesicular glutamate transporter 2 immunostained elements...
  80. Mendez J, Bourque M, Dal Bo G, Bourdeau M, Danik M, Williams S, et al. Developmental and target-dependent regulation of vesicular glutamate transporter expression by dopamine neurons. J Neurosci. 2008;28:6309-18 pubmed publisher
    ..form of cotransmission by showing that a subset of DA neurons both in vitro and in vivo expresses vesicular glutamate transporter 2 (VGluT2). Expression of VGluT2 decreases with age...
  81. Han Y, Li X, Wang S, Wei Y, Xu X. Presence of pups suppresses hunger-induced feeding in virgin adult mice of both sexes. Neuroscience. 2017;362:228-238 pubmed publisher
    ..Furthermore, chemogenetic activation of Vglut2+ neurons in the medial preoptic area (mPOA), a region critical for maternal behaviors and motivation, was ..
  82. Kashani A, Lepicard E, Poirel O, Videau C, David J, Fallet Bianco C, et al. Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease. Neurobiol Aging. 2008;29:1619-30 pubmed
    ..terminals in AD using the first available specific markers, the vesicular glutamate transporters VGLUT1 and VGLUT2. We quantified VGLUT1 and VGLUT2 in the prefrontal dorsolateral cortex (Brodmann area 9) of controls and AD ..
  83. Hrabovszky E, Molnár C, Nagy R, Vida B, Borsay B, Rácz K, et al. Glutamatergic and GABAergic innervation of human gonadotropin-releasing hormone-I neurons. Endocrinology. 2012;153:2766-76 pubmed publisher
    ..axons were detected with antisera against the major vesicular glutamate transporter (VGLUT) isoforms, VGLUT1 and VGLUT2. The relative incidences of GABAergic and glutamatergic axonal appositions to GnRH-immunoreactive neurons were ..
  84. Takamori S, Rhee J, Rosenmund C, Jahn R. Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2). J Neurosci. 2001;21:RC182 pubmed
    ..as vesicular glutamate transporter with properties very similar to VGLUT1 and propose to rename the protein VGLUT2. VGLUT2 is highly enriched in synaptic vesicles...
  85. Almqvist J, Huang Y, Laaksonen A, Wang D, Hovmöller S. Docking and homology modeling explain inhibition of the human vesicular glutamate transporters. Protein Sci. 2007;16:1819-29 pubmed
    ..Docking of VGLUT1 substrates to this pore localizes two different binding sites, to which inhibitors also bind with an overall trend in binding affinity that is in agreement with previously published experimental data. ..
  86. Garcia Marin V, Ahmed T, Afzal Y, Hawken M. Distribution of vesicular glutamate transporter 2 (VGluT2) in the primary visual cortex of the macaque and human. J Comp Neurol. 2013;521:130-51 pubmed publisher
    ..Thalamic afferent terminals are preferentially labeled by an isoform of the vesicular glutamate transporter, VGluT2. The goal of our study was to determine the distribution of VGluT2-ir puncta in macaque and human visual cortex...
  87. Wu M, Tollkuhn J. Estrogen receptor alpha is required in GABAergic, but not glutamatergic, neurons to masculinize behavior. Horm Behav. 2017;95:3-12 pubmed publisher
    ..We deleted ERα in excitatory or inhibitory neurons using either a Vglut2 or Vgat driver and assessed male behaviors...
  88. Wang W, Zou Z, Tan X, Zhang R, Ren C, Yao X, et al. Enhancement in Tonically Active Glutamatergic Inputs to the Rostral Ventrolateral Medulla Contributes to Neuropathic Pain-Induced High Blood Pressure. Neural Plast. 2017;2017:4174010 pubmed publisher
    ..05) showed an increase in glutamate content and expression of glutaminase 2, vesicular glutamate transporter 2 proteins, and c-fos...
  89. Tsutsumi S, Kamata N, Vokes T, Maruoka Y, Nakakuki K, Enomoto S, et al. The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD). Am J Hum Genet. 2004;74:1255-61 pubmed publisher
    ..Cellular localization to the endoplasmic reticulum suggests a role for GDD1 in the regulation of intracellular calcium homeostasis...
  90. Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, et al. Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter. J Neurochem. 2000;74:2622-5 pubmed
    We have isolated a human cDNA encoding a protein, designated DNPI, that shows 82% amino acid identity and 92% similarity to the human brain-specific Na(+)-dependent inorganic phosphate (Na(+)/P(i)) cotransporter (BNPI), which is localized ..
  91. Scott A, Alfredson H, Forsgren S. VGluT2 expression in painful Achilles and patellar tendinosis: evidence of local glutamate release by tenocytes. J Orthop Res. 2008;26:685-92 pubmed
    ..were examined immunohistochemically using antibodies against vesicular glutamate transporters (VGluT1 and VGluT2), as indirect markers of glutamate release. In situ hybridization for VGluT2 mRNA was also conducted...
  92. Oni Orisan A, Kristiansen L, Haroutunian V, Meador Woodruff J, McCullumsmith R. Altered vesicular glutamate transporter expression in the anterior cingulate cortex in schizophrenia. Biol Psychiatry. 2008;63:766-75 pubmed
    ..b>Vesicular glutamate transporter 2 was unchanged at both levels of gene expression...