SLC17A5

Summary

Gene Symbol: SLC17A5
Description: solute carrier family 17 (anion/sugar transporter), member 5
Alias: AST, ISSD, NSD, SIALIN, SIASD, SLD, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter, membrane glycoprotein HP59, sialic acid storage disease, sialin, sodium/sialic acid cotransporter, solute carrier family 17 member 5, solute carrier family 17, member 5, vesicular H(+)/Aspartate-glutamate cotransporter
Species: human

Top Publications

  1. ncbi Pruritus in chronic hepatitis C: association with high serum bile acids, advanced pathology, and bile duct abnormalities
    E Lebovics
    Department of Medicine, New York Medical College, Valhalla 10595, USA
    Dig Dis Sci 42:1094-9. 1997
  2. ncbi [Five cases of erythema infectiosum in adults]
    T Takahashi
    Department of Medicine, Yame General Hospital
    Kansenshogaku Zasshi 75:469-72. 2001
  3. ncbi Prevalence of hepatitis B and C virus markers in outpatients of Mongolian general hospitals
    S Fujioka
    First Department of Internal Medicine, Okayama University Medical School
    Kansenshogaku Zasshi 72:5-11. 1998
  4. ncbi Determination of chemopreventive role of Foeniculum vulgare and Salvia officinalis infusion on trichloroacetic acid-induced increased serum marker enzymes lipid peroxidation and antioxidative defense systems in rats
    Ismail Celik
    Faculty of Art and Science, Department of Biology, Yuzuncu Yil University, Van, Turkey
    Nat Prod Res 22:66-75. 2008
  5. ncbi Growth hormone and carbohydrate intolerance in cirrhosis
    T P Shankar
    Department of Medicine, VA Medical Center, Memphis, Tennessee
    Horm Metab Res 20:579-83. 1988
  6. ncbi [A case of neonatal herpes infection which proved to be a mixed infection of herpes simplex virus type 1 and type 2]
    Y Minohara
    Department of Pediatrics, St. Marianna University, School of Medicine
    Kansenshogaku Zasshi 70:627-30. 1996
  7. ncbi Comparison of solutions for preservation of the rabbit liver as tested by isolated perfusion
    G den Butter
    Department of Surgery, University of Wisconsin, Madison 53792, USA
    Transpl Int 8:466-71. 1995
  8. ncbi Clinical, biochemical, and molecular diagnosis of a free sialic acid storage disease patient of moderate severity
    Robert Kleta
    Department of Pediatrics, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Mol Genet Metab 82:137-43. 2004
  9. ncbi Relationship of the subgingival microbiota to a chairside test for aspartate aminotransferase in gingival crevicular fluid
    M Y Wong
    School of Dentistry, College of Medicine, National Taiwan University, Taipei
    J Periodontol 70:57-62. 1999
  10. ncbi Changes in vitamin E concentration after surgery and anesthesia
    J Zunic
    Department of Anesthesiology and Intensive Care, County Hospital Karlovac, Croatia
    Coll Antropol 21:327-34. 1997

Research Grants

  1. Relationship of metabolic abnormalities to hepatic steatosis in HIV
    Richard Sterling; Fiscal Year: 2007
  2. Role of 5-alpha Reductase in Testosterone Actions
    Shalendar Bhasin; Fiscal Year: 2007
  3. High resolution functional MRI of columnar structures
    Ravi Menon; Fiscal Year: 2007
  4. Avoiding toxicity associated with MTP ablation
    M Mahmood Hussain; Fiscal Year: 2010
  5. Pontine Control of REM Atonia
    Elda Arrigoni; Fiscal Year: 2010
  6. Pontine Control of REM Atonia
    Elda Arrigoni; Fiscal Year: 2009
  7. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2005
  8. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2004
  9. Alcohol & Antiretrovirals in HIV Infection, Oxidative Stress and Liver Disease
    Marianna K Baum; Fiscal Year: 2010
  10. Pontine circuitry regulating REM sleep and atonia
    Jun Lu; Fiscal Year: 2009

Detail Information

Publications146 found, 100 shown here

  1. ncbi Pruritus in chronic hepatitis C: association with high serum bile acids, advanced pathology, and bile duct abnormalities
    E Lebovics
    Department of Medicine, New York Medical College, Valhalla 10595, USA
    Dig Dis Sci 42:1094-9. 1997
    ..Pruritus was present in nine (5.1%) patients. Serum AST, ALT, alkaline phosphatase, GGTP, total bilirubin, and ferritin were similar in pruritics and controls...
  2. ncbi [Five cases of erythema infectiosum in adults]
    T Takahashi
    Department of Medicine, Yame General Hospital
    Kansenshogaku Zasshi 75:469-72. 2001
    ..Rheumatoid factor (RF) was also detected by latex fixation test. Her AST was 51 IU/L, ALT 68 IU/L and LDH 568 IU/L...
  3. ncbi Prevalence of hepatitis B and C virus markers in outpatients of Mongolian general hospitals
    S Fujioka
    First Department of Internal Medicine, Okayama University Medical School
    Kansenshogaku Zasshi 72:5-11. 1998
    ..05). Transaminase levels were higher in group 1 (median (range) IU/l of AST, ALT; 29 (13-95), 32 (9-144) and group 3 (25 (15-187), 22 (8-185)) than in group 4 (18 (9-13), 15 (6-133); p < 0...
  4. ncbi Determination of chemopreventive role of Foeniculum vulgare and Salvia officinalis infusion on trichloroacetic acid-induced increased serum marker enzymes lipid peroxidation and antioxidative defense systems in rats
    Ismail Celik
    Faculty of Art and Science, Department of Biology, Yuzuncu Yil University, Van, Turkey
    Nat Prod Res 22:66-75. 2008
    ..of the plant infusions were evaluated by measuring levels of serum marker enzymes [aspartate aminotransferase (AST), alanin aminotransferase (ALT), creatine phosphokinase (CPK), acid phosphatase (ACP), alkaline phosphatase (ALP) ..
  5. ncbi Growth hormone and carbohydrate intolerance in cirrhosis
    T P Shankar
    Department of Medicine, VA Medical Center, Memphis, Tennessee
    Horm Metab Res 20:579-83. 1988
    ..Glucose tolerance tests (GTT), intravenous insulin tolerance tests (IVITT), arginine stimulation tests (AST) and glucose clamp studies before and during GH suppression with somatostatin were performed in a group of patients ..
  6. ncbi [A case of neonatal herpes infection which proved to be a mixed infection of herpes simplex virus type 1 and type 2]
    Y Minohara
    Department of Pediatrics, St. Marianna University, School of Medicine
    Kansenshogaku Zasshi 70:627-30. 1996
    ..b>AST was 1042 IU/L, and ALT 206 IU/L. In spite of treatment, the patient died at the age of 12 days...
  7. ncbi Comparison of solutions for preservation of the rabbit liver as tested by isolated perfusion
    G den Butter
    Department of Surgery, University of Wisconsin, Madison 53792, USA
    Transpl Int 8:466-71. 1995
    ..LDH and AST release were greater in HTK-preserved livers than in UW livers, but these differences were not statistically ..
  8. ncbi Clinical, biochemical, and molecular diagnosis of a free sialic acid storage disease patient of moderate severity
    Robert Kleta
    Department of Pediatrics, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Mol Genet Metab 82:137-43. 2004
    The allelic autosomal recessive lysosomal storage disorders Salla disease and infantile free sialic acid storage disease (ISSD) result from mutations in SLC17A5...
  9. ncbi Relationship of the subgingival microbiota to a chairside test for aspartate aminotransferase in gingival crevicular fluid
    M Y Wong
    School of Dentistry, College of Medicine, National Taiwan University, Taipei
    J Periodontol 70:57-62. 1999
    The aim of the present study was to evaluate the association between the occurrence of certain specific periodontal pathogens and aspartate aminotransferase (AST) levels in gingival crevicular fluid (GCF).
  10. ncbi Changes in vitamin E concentration after surgery and anesthesia
    J Zunic
    Department of Anesthesiology and Intensive Care, County Hospital Karlovac, Croatia
    Coll Antropol 21:327-34. 1997
    ..Simultaneously activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyltransferase (GGT) were determined. Statistical analysis: ANOVA, Tukay HSD test...
  11. ncbi Different effects on the responses of functional pre- and postsynaptic 5-HT1A receptors by repeated treatment of rats with the 5-HT1A receptor agonist 8-OH-DPAT
    L G Larsson
    Department of Neuropharmacology, CNS 1, Astra Research Centre, , Sweden
    Neuropharmacology 29:85-91. 1990
    ..hippocampus and hypothalamus, after inhibition of L-aromatic amino acid decarboxylase by 3-hydroxybenzylhydrazine (NSD 1015), that is due to stimulation of autoreceptors on the 5-HT cell bodies...
  12. ncbi Prenatal diagnosis of free sialic acid storage disorders (SASD)
    Nina Aula
    Neuroscience Center, University of Helsinki, Finland
    Prenat Diagn 26:655-8. 2006
    Free sialic acid storage disorders, Salla disease (SD) and Infantile sialic acid storage disease (ISSD), are lysosomal storage diseases due to impaired function of a sialic acid transporter, sialin, at the lysosomal membrane...
  13. ncbi Autonomic stress tests in obstructive sleep apnea syndrome and snoring
    D Veale
    Department of Pneumonology, CHRU, Grenoble, France
    Sleep 15:505-13. 1992
    ..A significant difference between normal abnormal autonomic stress test (AST) groups was observed in the evening and the morning as regards cumulative time spent under 90% SaO2 and minimal ..
  14. ncbi [Drug-induced hepatotoxicity caused by anti-tuberculosis drugs in tuberculosis patients complicated with chronic hepatitis]
    Yugo Kaneko
    Department of Pulmonary Medicine, Jikei University School of Medicine, 4 11 1, Izumihoncho, Komae shi, Tokyo 201 8601, Japan
    Kekkaku 83:13-9. 2008
    ....
  15. ncbi The lysosomal sialic acid transporter sialin is required for normal CNS myelination
    Laura M Prolo
    Department of Neurology and Neurological Sciences and Graduate Program in Neuroscience, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 29:15355-65. 2009
    Salla disease and infantile sialic acid storage disease are autosomal recessive lysosomal storage disorders caused by mutations in the gene encoding sialin, a membrane protein that transports free sialic acid out of the lysosome after it ..
  16. ncbi Novel form of intermediate salla disease: clinical and neuroimaging features
    Richard P Morse
    Department of Pediatrics, Division of Pediatric Neurology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Child Neurol 20:814-6. 2005
    ..Infantile sialic acid storage disease has a severe phenotype, and Salla disease (Finnish variant) is generally milder in phenotype; ..
  17. ncbi Effects of four Indian medicinal herbs on Isoniazid-, Rifampicin- and Pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs
    Meghna R Adhvaryu
    Bapalal Vaidya Botanical Research Centre, Department of Biosciences, Veer Narmad South Gujarat University, 110, Nehru Nagar Society, Ichchhanath Road, Surat 395007, India
    World J Gastroenterol 13:3199-205. 2007
    ....
  18. ncbi Retrospective analysis of transient elevations in alanine aminotransferase during long-term treatment with acetaminophen in osteoarthritis clinical trials
    Edwin K Kuffner
    McNeil Consumer Healthcare, Division of McNeil PPC, Inc, Fort Washington, PA 19034, USA
    Curr Med Res Opin 22:2137-48. 2006
    ..9 g daily than in patients receiving placebo, and the rates were higher than aminotransferase values observed in some previous osteoarthritis studies with acetaminophen...
  19. ncbi Relationship between hepatitis B virus DNA levels and liver histology in patients with chronic hepatitis B
    Jie Shao
    Department of Hepatic Disease, People s Hospital, Peking University, Beijing 100034, China
    World J Gastroenterol 13:2104-7. 2007
    ..To study the relationship between hepatitis B virus (HBV) DNA levels and liver histology in patients with chronic hepatitis B (CHB) and to determine the prevalence and characteristics of hepatitis B e antigen (HBeAg) negative patients...
  20. ncbi A pilot study to compare natural health product-drug interactions in two databases in Canada
    Guillaume Faubert
    Pharmacy Department, Pharmaceutical Practice Research Unit, CHU Sainte Justine, 3175, Chemin de la Cote Ste Catherine, Montreal, QC, H3T 1C5, Canada
    Pharm World Sci 32:179-86. 2010
    ..The aim of this article is to evaluate and compare two natural health product databases for the purpose of integrating them into a pharmacy information system in Canada...
  21. ncbi [Secular increase in the incidence rate of drug-induced hepatitis due to anti-tuberculosis chemotherapy including isoniazid and rifampicin]
    Naohiro Nagayama
    Department of Respiratory Medicine, Tokyo National Hospital, 3 1 1, Takeoka, Kiyose shi, Tokyo 204 8585, Japan
    Kekkaku 78:339-46. 2003
    ..The criteria for selection of the patients were as follows. 1. The serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were measured before, and one month (20-40 days) and 2 months (45-75 days) ..
  22. ncbi [Effects of astragaloside and Panax notoginseng saponins combination on oxidative stress of cerebral ischemic reperfusion injury in mice]
    Hua Tan
    Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, China
    Zhong Xi Yi Jie He Xue Bao 8:448-52. 2010
    To investigate the influence of astragaloside (AST) and Panax notoginseng saponins (PNS) combination on oxidative stress of brain tissues in C57BL/6 mice with cerebral ischemia-reperfusion injury.
  23. ncbi Tissue-specific alterations in insulin-like growth factor-I concentrations in response to 3,3',5-triiodo-L-thyronine supplementation in the growth hormone receptor-deficient sex-linked dwarf chicken
    R Vasilatos-Younken
    Department of Poultry Science, Pennsylvania State University, University Park, Pennsylvania, 16802, USA
    Gen Comp Endocrinol 105:31-9. 1997
    ..The recessive sex-linked dwarfing (SLD) gene (dw) in chickens results in a lack of functional target tissue GH receptors due to a variety of molecular ..
  24. ncbi Carbon tetrachloride-induced changes in the activity of phase II drug-metabolizing enzyme in the liver of male rats: role of antioxidants
    S A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, P O Box 832, 163 Horreya Avenue, Alexandria, Egypt
    Toxicology 165:217-24. 2001
    ..tetrachloride-induced changes in the activity of alanine amino transferase (ALT), aspartate amino transferase (AST), glutathione S-transferase (GST), and the level of glutathione (GSH) and thiobarbituric acid reactive substances (..
  25. ncbi Early fractionation methods and the origins of the NSD concept
    H D Thames
    Department of Biomathematics, University of Texas System Cancer Center, Houston 77030
    Acta Oncol 27:89-103. 1988
    ..of fraction number and overall time could be separated; these developments constituted the foundation of the Ellis NSD model...
  26. ncbi Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats
    Ru Tao Hong
    Department of Geriatrics Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
    World J Gastroenterol 15:1452-8. 2009
    ..To investigate the protective effects of melatonin on carbon tetrachloride (CCl4)-induced hepatic fibrosis in experimental rats...
  27. ncbi Longitudinal monitoring of subgingival colonization by Actinobacillus actinomycetemcomitans, and crevicular alkaline phosphatase and aspartate aminotransferase activities around orthodontically treated teeth
    Giuseppe Perinetti
    Unit of Orthodontics, Department of Oral Sciences, School of Dentistry, University G D Annunzio, Chieti, Italy
    J Clin Periodontol 31:60-7. 2004
    ..of Actinobacillus actinomycetemcomitans (Aa) and alkaline phosphatase (ALP) and aspartate aminotransferase (AST) activities in gingival crevicular fluid (GCF) in order to assess whether these parameters have potential as ..
  28. ncbi Structure-function studies of the SLC17 transporter sialin identify crucial residues and substrate-induced conformational changes
    Pascal Courville
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 285:19316-23. 2010
    Salla disease and infantile sialic acid storage disorder are human diseases caused by loss of function of sialin, a lysosomal transporter that mediates H(+)-coupled symport of acidic sugars N-acetylneuraminic acid and glucuronic acid out ..
  29. ncbi Betaine inhibits toll-like receptor 4 expression in rats with ethanol-induced liver injury
    Qing Zhao Shi
    Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
    World J Gastroenterol 16:897-903. 2010
    ..To test whether ethanol feeding could induce Toll-like receptor 4 (TLR4) responses, assess the hepatoprotective effect of betaine and its inhibitive effect on TLR4 in animal models of alcoholic liver injury...
  30. ncbi High adiponectin and TNF-alpha levels in moderate drinkers suffering from liver steatosis: comparison with non drinkers suffering from similar hepatopathy
    David Stejskal
    Metabolic and Diabetologic Out Patient Centre and Department of Laboratory Medicine, Hospital Sternberk, Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 149:93-9. 2005
    ..for serum concentrations of AN, glucose, triglycerides, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and glutamate transferase (GMT) activity; carbohydrate-deficient transferrin (CDT%) a marker of chronic alcohol ..
  31. ncbi Prevalence of enterotoxin genes in Aeromonas spp. isolated from children with diarrhea, healthy controls, and the environment
    M J Albert
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    J Clin Microbiol 38:3785-90. 2000
    ..Recently, we have characterized a heat-labile cytotonic enterotoxin (Alt), a heat-stable cytotonic enterotoxin (Ast), and a cytotoxic enterotoxin (Act) from a diarrheal isolate of Aeromonas hydrophila...
  32. ncbi Evidence of two separate mechanisms for the decrease in aryl sulfotransferase activity in rat liver during early stages of 2-acetylaminofluorene-induced hepatocarcinogenesis
    D P Ringer
    Biochemical Pharmacology Section, Samuel Roberts Noble Foundation, Inc, Ardmore, Oklahoma
    Mol Carcinog 9:2-9. 1994
    ..basis for the downregulation of the important detoxication/bioactivation enzyme aryl sulfotransferase IV (AST IV) during 2-acetylaminofluorene (2AAF)-induced hepatocarcinogenesis...
  33. ncbi Gemfibrozil-induced myositis in a patient with normal renal function
    Martin Hahn
    Tennessee Valley Health Care System, Nashville, TN 37129, USA
    Ann Pharmacother 44:211-4. 2010
    ..To describe a case of gemfibrozil monotherapy-induced myositis in a patient with normal renal function..
  34. ncbi Effect of flibanserin (BIMT 17), fluoxetine, 8-OH-DPAT and buspirone on serotonin synthesis in rat brain
    A Brambilla
    Department of Biology, Boehringer Ingelheim Italia, Milan, Italy
    Eur Neuropsychopharmacol 10:63-7. 1999
    ..5-HTP) after blockade of aromatic amino acid decarboxylase induced by m-hydroxybenzylhydrazine (NSD-1015), at 100 mg/kg i.p., 30 min before sacrifice...
  35. ncbi Modulation of key metabolic enzyme of Labeo rohita (Hamilton) juvenile: effect of dietary starch type, protein level and exogenous alpha-amylase in the diet
    Shivendra Kumar
    Department of Fish Nutrition and Biochemistry, Central Institute of Fisheries Education, Versova, Mumbai 400061, India
    Fish Physiol Biochem 35:301-15. 2009
    ..dehydrogenase, G6PD) and amino acid metabolism (alanine amino transferase, ALT and aspartate amino transferase, AST) in Labeo rohita. Three hundred and sixty juveniles (average weight 10 +/- 0...
  36. ncbi Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation
    Miao Xian Dong
    The Institute of Medicine, Qiqihar Medical University, JianHua District, Qiqihar, Heilongjiang Province, China
    World J Gastroenterol 15:4753-62. 2009
    ..To investigate the role of emodin in protecting the liver against fibrogenesis caused by carbon tetrachloride (CCl(4)) in rats and to further explore the underlying mechanisms...
  37. ncbi Heparin sensitivity test for patients requiring cardiopulmonary bypass
    William J DeBois
    New York Presbyterian Hospital Weill Cornell Medical Center, NY 10021, USA
    J Extra Corpor Technol 38:307-9. 2006
    ..An anticoagulation sensitivity test (AST) was developed by adding 12 units of porcine mucosa heparin to the ACT tube (International Technidyne, celite type)...
  38. ncbi Elevated liver enzyme activity in construction workers: prevalence and impact on early retirement and all-cause mortality
    V Arndt
    Department of Epidemiology, University of Ulm, Germany
    Int Arch Occup Environ Health 71:405-12. 1998
    Gamma-glutamyl transferase (GGT), alanine transaminase (ALT), and aspartate transaminase (AST) are widely used as markers of hepatobiliary disorders in occupational health surveillance...
  39. ncbi Comparison of blood aminotransferase methods for assessment of myopathy and hepatopathy in Florida manatees (Trichechus manatus latirostris)
    Kendal E Harr
    FVP Consultants, Inc, Bushnell, Florida 33513, USA
    J Zoo Wildl Med 39:180-7. 2008
    Muscle injury is common in Florida manatees (Trichechus manatus latirostris). Plasma aspartate aminotransferase (AST) is frequently used to assess muscular damage in capture myopathy and traumatic injury...
  40. ncbi Scapholunate dissociation: an experimental kinematic study of two types of indirect soft tissue repairs
    A B Dagum
    Department of Surgery, University of Toronto, Ontario, Canada
    J Hand Surg Am 22:714-9. 1997
    Indirect soft tissue repairs of scapholunate dissociation (SLD) address the pathophysiology but have been criticized for significantly limiting wrist flexion and altering wrist kinematics...
  41. ncbi Nasal septum deviation in newborns
    A Soboczyński
    ORL Clinic, Academy of Medicine, Poznan, Poland
    Acta Otorhinolaryngol Belg 46:263-5. 1992
    The patency of the nose is very important for the newborn. Nasal septum deviation (NSD) is one of the most important factors causing disorders of the patency of the nose. It is usually the result of mechanical trauma...
  42. ncbi Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv)
    F Arguello
    Strong Children s Research Center, University of Rochester School of Medicine, New York 14642
    Cancer Res 52:2304-9. 1992
    ..26 melanoma cells into mutant Sl/Sld and W/Wv mice...
  43. ncbi [How brain-dead state affects the hepatic morphology and function of Ba-Ma mini pigs and its mechanism]
    Shui jun Zhang
    Department of General Surgery, The First Affiliated Hospital, Zhenzhou University, Zheng Zhou 450052, China
    Zhonghua Yi Xue Za Zhi 86:1244-8. 2006
    ..To investigate the impact of brain death (BD) on the morphology and function of liver...
  44. ncbi Protective effects of L-arginine against ischemia-reperfusion injury in non-heart beating rat liver graft
    Jin Gong
    Department of Surgery, First Affiliated Hospital, Jinan University, Guangzhou 510630, China
    Hepatobiliary Pancreat Dis Int 7:481-4. 2008
    ..Prevention of liver injury in NHBDs will benefit the results of transplantation. This study was conducted to evaluate the protective effects of L-arginine on liver grafts from NHBDs...
  45. ncbi Aspartat aminotransferase--a marker of periodontal disease activity
    M Ivić-Kardum
    Department of Periodontology, School of Dental Medicine, Zagreb, Croatia
    Coll Antropol 23:111-6. 1999
    ..Aspartat aminotransferase (AST) activity in gingival crevicular fluid is a potential quantitative marker of periodontal disease activity...
  46. ncbi Glutathione S-transferase Alpha 1-1 and aminotransferases in umbilical cord blood
    M F Knapen
    Department of Obstetrics and Gynecology, University Hospital St Radboud, Nijmegen, Netherlands
    Early Hum Dev 54:129-35. 1999
    ..with that of the well known liver function markers alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in arterial and corresponding venous umbilical cord blood of 93 patients...
  47. ncbi Safety and efficacy of combined ezetimibe/simvastatin treatment and simvastatin monotherapy in patients with non-alcoholic fatty liver disease
    Tatjana Abel
    Outpatient Department, National Health Centre, Budapest, Hungary
    Med Sci Monit 15:MS6-11. 2009
    ..The secondary goal of this investigation was to compare the safety and efficacy of combined ezetimibe / simvastatin treatment with simvastatin monotherapy...
  48. ncbi Sleep deprivation affects speech
    Y Harrison
    Loughborough University, Leicestershire
    Sleep 20:871-7. 1997
    ..subjects underwent two counterbalanced 36-hour trials involving sleep deprivation (SD) and no sleep deprivation (NSD)...
  49. ncbi Parkinson's disease as a neuroendocrine disorder of circadian function: dopamine-melatonin imbalance and the visual system in the genesis and progression of the degenerative process
    Gregory L Willis
    The Bronowski Institute of Behavioural Neuroscience, Neurosciences Section, Coliban Medical Centre, Kyneton, Victoria, Australia
    Rev Neurosci 19:245-316. 2008
    For more than 50 years, Parkinson's disease (PD) has been conceptualized as a product of nigro-striatal dopamine (NSD) system degeneration...
  50. ncbi Bioavailability of astaxanthin stereoisomers from wild (Oncorhynchus spp.) and aquacultured (Salmo salar) salmon in healthy men: a randomised, double-blind study
    Corinna E Rüfer
    Institute of Nutritional Physiology, Federal Research Centre for Nutrition and Food, Karlsruhe, Germany
    Br J Nutr 99:1048-54. 2008
    ..was to investigate the bioavailability and the configurational isomer distribution of the carotenoid astaxanthin (AST) in human plasma after ingestion of wild (Oncorhynchus spp.) and aquacultured (Salmo salar) salmon...
  51. ncbi Frequency of inappropriate continuation of acid suppressive therapy after discharge in patients who began therapy in the surgical intensive care unit
    Catherine E Murphy
    Department of Pharmacotherapy, Fletcher Allen Health Care, Burlington, Vermont, USA
    Pharmacotherapy 28:968-76. 2008
    To determine the frequency with which patients who begin to receive stress ulcer prophylaxis in the surgical intensive care unit (SICU) are discharged receiving inappropriate acid suppressive therapy (AST).
  52. ncbi Demonstration of antihistamine properties with AST-1: a bioactive extract from garden slugs (Diplosolenodes occidentalis)
    A Jacob
    Department of Basic Medical Sciences, The University of the West Indies, Kingston 7, Jamaica
    West Indian Med J 56:11-6. 2007
    ..to histamine from allergic sensitization, the authors investigated the effects of a semi-pure alcoholic extract (AST-1) on histamine-induced contraction of the guinea pig in vitro tracheal muscle preparation and cutaneous allergic ..
  53. ncbi Aspartate aminotransferase activity in gingival crevicular fluid during orthodontic treatment. A controlled short-term longitudinal study
    Giuseppe Perinetti
    Unit of Biochemistry, Department of Oral Sciences, Dental School, University G D Annunzio, Chieti, Italy
    J Periodontol 74:145-52. 2003
    ..This study used a longitudinal design to examine aspartate aminotransferase (AST) activity in gingival crevicular fluid (GCF) in order to assess whether AST in GCF has potential as a possible ..
  54. ncbi Quantitative evaluation of liver function with MRI Using Gd-EOB-DTPA
    Hun Kyu Ryeom
    Department of Radiology, Kyungpook National University School of Medicine, Taegu, Korea
    Korean J Radiol 5:231-9. 2004
    ..The purpose of this study is to develop a noninvasive method of quantitation of the hepatic function using Gd-EOB-DTPA through the deconvolution analysis...
  55. ncbi Multiplex PCR method for detection of three Aeromonas enterotoxin genes
    Cesar I Bin Kingombe
    Microbiology Research Division, Bureau of Microbial Hazards, Food Directorate, Health Products and Food Branch, Sir Frederick G Banting Research Centre, Ottawa, Ontario, Canada
    Appl Environ Microbiol 76:425-33. 2010
    ..of specific primers was developed for the detection of the cytotoxic (act), heat-labile (alt), and heat-stable (ast) enterotoxin genes in Aeromonas spp...
  56. ncbi [The changes and significance of multiple organ functions in acute pancreatitis patients under hypoxic condition on plateau]
    Hai Hong Zhu
    Department of General Surgery, People s Hospital of Qinghai Province, Xining 810007, Qinghai, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:210-3. 2010
    ..To explore characteristics of the pathogenesis and progression of the acute pancreatitis (AP) in high altitude and the relationship between AP and plateau erythrocythemia...
  57. ncbi [Three cases with acute encephalopathy related with adenovirus type 7 infection]
    N Ohtsuki
    Department of Pediatrics, Urafune Hospital of Yokohama City University, School of Medicine
    No To Hattatsu 32:68-72. 2000
    ..Seizures in all the patients developed from 8 to 10 days after the onset of pyrexia. The values of serum AST, LDH and CRP elevated and those of WBC and serum protein decreased at the onset of encephalopathy...
  58. ncbi [Evaluation of automated architect syphilis TP as a diagnostic laboratory screening test for syphilis]
    Jeeyong Kim
    Department of Laboratory Medicine, Korea University Hospital, Seoul, Korea
    Korean J Lab Med 28:475-82. 2008
    ..The aim of the study was to establish a new syphilis test algorithm using Architect Syphilis TP (Abbott Japan, Japan: AST), a fully automated treponemal antibody test, as a screening test in a university hospital laboratory...
  59. ncbi Diagnostic accuracy of plain radiographs and cineradiography in diagnosing traumatic scapholunate dissociation
    Jenny Pliefke
    Department of Hand Surgery, Replantation Surgery, and Microsurgery, Unfallkrankenhaus Berlin, Warener Strasse 7, 12683 Berlin, Germany
    Skeletal Radiol 37:139-45. 2008
    Missed tears of the scapholunate ligament (SLL) and scapholunate dissociation (SLD) after wrist injuries pose a high risk of post-traumatic osteoarthritis of the carpus...
  60. ncbi Elevated liver enzyme tests among patients with rheumatoid arthritis or psoriatic arthritis treated with methotrexate and/or leflunomide
    J R Curtis
    Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, 510 20 Street South, FOT 840, Birmingham, AL 35294, USA
    Ann Rheum Dis 69:43-7. 2010
    ..RA) or psoriatic arthritis (PsA), the incidence of elevated alanine aminotransferase/aspartate aminotransferase (ALT/AST) enzymes associated with methotrexate (MTX), leflunomide (LEF) and MTX+LEF versus other DMARDs was examined.
  61. ncbi Relationship between crevicular aspartate aminotransferase levels and periodontal disease progression
    R J Oringer
    Department of Periodontics, State University of New York at Stony Brook, 11794 8703, USA
    J Periodontol 72:17-24. 2001
    Aspartate aminotransferase (AST), an enzyme released from necrotic cells, has been identified in gingival crevicular fluid (GCF), and elevated levels are associated with periodontal tissue destruction...
  62. ncbi Inflation of antishock trousers increases bronchial response to methacholine in healthy subjects
    J Regnard
    Laboratoire de Physiologie, Faculté de Médecine Cochin Port Royal, Paris, France
    J Appl Physiol 68:1528-33. 1990
    ..changes in lung volumes and in bronchial response to methacholine chloride (MC) challenge when antishock trousers (AST) were inflated at venous occlusion pressure in healthy subjects in the standing posture, a maneuver known to shift ..
  63. ncbi Spontaneous radiation-induced rib fractures in breast cancer patients treated with postmastectomy irradiation. A clinical radiobiological analysis of the influence of fraction size and dose-response relationships on late bone damage
    M Overgaard
    Department of Oncology and Radiotherapy, Radiumstationen, Aarhus, Denmark
    Acta Oncol 27:117-22. 1988
    ..6%) even though they had been treated with the aim to obtain equivalent biologic response according to the NSD formula...
  64. ncbi [Clinical studies on 35 patients with infection-related acute encephalopathy]
    S Kimura
    Department of Pediatrics, Urafune Hospital of Yokohama City University School of Medicine
    No To Hattatsu 30:244-9. 1998
    ..Serum AST were elevated in 7.7 and 6 cases in (3), (4) and (5), respectively...
  65. ncbi Comparison between fractionated high dose rate irradiation and continuous low dose rate irradiation in spheroids
    M Omura
    Department of Radiology, Yokohama City University School of Medicine, Yokohama, Japan
    Acta Oncol 37:681-6. 1998
    ..was independent of the fraction size of HDR irradiation administrated, and the repair of sublethal damage (SLD) was absent, suggesting that the sparing effect of fractionated HDR irradiations was absent in spheroids...
  66. ncbi Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease
    Shingo Hatakeyama
    Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu chou, Hirosaki 036 8562, Japan
    Int J Nephrol 2012:376128. 2012
    The oral adsorbent AST-120 has the potential to delay dialysis initiation and improve survival of patients on dialysis...
  67. ncbi Comparative study of C-Reactive Protein and other biochemical parameters in patients with hepatitis B and malaria in Calabar, Nigeria
    U K Amah
    Department of Chemical Pathology, College of Medicine Nnamdi Azikiwe University, Nnewi Campus
    Niger J Physiol Sci 26:109-12. 2011
    Serum levels of C-reactive proteins (CRP), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), total protein, albumin and globulins were investigated using high sensitivity Immunoturbidometric and colorimetric techniques in ..
  68. ncbi The effect of assisted and resisted sprint training on acceleration and velocity in Division IA female soccer athletes
    David E Upton
    Exercise Physiology Laboratory, Department of Kinesiology, Texas Christian University, Fort Worth, Texas, USA
    J Strength Cond Res 25:2645-52. 2011
    ..effects of a 4-week, 12-session training program using resisted sprint training (RST), assisted sprint training (AST), and traditional sprint training (TST) on maximal velocity and acceleration in National Collegiate Athletic ..
  69. ncbi Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study
    Irina A Kirpich
    Department of Biochemistry, Northern State Medical University, 161020, Arkhangelsk, Russia
    Alcohol 42:675-82. 2008
    ..43 vs. 5.5 log CFU/g). The mean baseline alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (GGT) activities were significantly elevated in the alcoholic group compared to ..
  70. ncbi Reduced muscle strength and functional performance in men with prostate cancer undergoing androgen suppression: a comprehensive cross-sectional investigation
    D A Galvão
    School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
    Prostate Cancer Prostatic Dis 12:198-203. 2009
    This study examined the effects of androgen suppression therapy (AST) on upper and lower body muscle strength and a range of direct measures of physical performance using a cross-sectional design with 118 men (48 men undertaking AST for ..
  71. ncbi An oral adsorbent, AST-120, combined with a low-protein diet and RAS blocker, for chronic kidney disease
    Noriaki Yorioka
    Department of Advanced Nephrology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Nephrol 21:213-20. 2008
    ..The oral adsorbent AST-120 (Kremezin) has a renoprotective effect by reducing serum levels of uremic toxins...
  72. ncbi Prevalence and long-term course of macro-aspartate aminotransferase in children
    Maria Caropreso
    Department of Pediatrics, University of Naples Federico II, Naples, Italy
    J Pediatr 154:744-8. 2009
    To investigate the prevalence, association with clinical conditions, and long-term course of macro-aspartate aminotransferase (macro-AST).
  73. ncbi Oral charcoal adsorbent (AST-120) prevents progression of cardiac damage in chronic kidney disease through suppression of oxidative stress
    Hideki Fujii
    Division of Nephrology and Kidney Center, Kobe University School of Medicine, Kobe, Japan
    Nephrol Dial Transplant 24:2089-95. 2009
    ..Increased oxidative stress plays a role in the pathogenesis of CVD in CKD patients. The oral charcoal adsorbent AST-120 attenuates the progression of CKD possibly by removing uraemic toxins such as indoxyl sulfate (IS), and reduces ..
  74. ncbi Identification of a vesicular aspartate transporter
    Takaaki Miyaji
    Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700 8530, Japan
    Proc Natl Acad Sci U S A 105:11720-4. 2008
    ..Here, we show that sialin, a lysosomal H(+)/sialic acid cotransporter, is present in hippocampal synaptic vesicles and pineal SLMVs...
  75. ncbi [Clinical value of hepatic fibrosis parameters and serum ferritin in obese children with nonalcoholic fatty liver disease]
    Hong bo Shi
    Department of Endocrinology, The Affiliated Children s Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 37:245-9. 2008
    ..To determine the clinical value of hepatic fibrosis parameters and serum ferritin (SF) in obese children with nonalcoholic fatty liver disease...
  76. ncbi Hepatic blood flow plays an important role in ischemia-reperfusion injury
    Dympna M Kelly
    Department of General Surgery, Cleveland Clinic, Cleveland, OH 44195, USA
    Liver Transpl 17:1448-56. 2011
    ..IR injury was defined by the aspartate aminotransferase (AST) level on postoperative day (POD) 2, and the patients were divided into 3 groups: (1) mild IR injury [AST < 500 ..
  77. ncbi Sleep disturbance in dementia with Lewy bodies and Alzheimer's disease: a multicenter analysis
    Donald L Bliwise
    Department of Neurology, Emory University School of Medicine, Wesley Woods Health Center, 1841 Clifton Road, Atlanta, GA 30329, USA
    Dement Geriatr Cogn Disord 31:239-46. 2011
    ..We sought to confirm such observations using a large, prospectively collected, standardized, multicenter-derived database, i.e. the National Alzheimer's Coordinating Center Uniform Data Set...
  78. ncbi Rectification of width and area of the ciliary cleft in dogs
    Manabu Kawata
    Laboratory of Advanced Diagnosis and Treatment, Department of Advanced Clinical Medicine, Course of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Izumisano, Japan
    J Vet Med Sci 72:533-7. 2010
    ..correlation was found between OAL and the distance of the Schwalbe's line to the anterior lenticular capsule (SLD; r=0.87, p<0.001), suggesting that SLD could rectify canine OS...
  79. ncbi Creatine phosphokinase and aspartate aminotransverase profiles and its relation to the severity of uterine torsion in Egyptian buffalo
    S M Amin
    Department of Theriogenology, Faculty of Veterinary Medicine, Zagazig University, El Zeraa Str 114, 44519 Zagazig, Egypt
    Anim Reprod Sci 123:163-8. 2011
    ..the relationship between the serum concentrations of creatine phosphokinase (CPK), aspartate aminotransverase (AST) and the severity of uterine torsion...
  80. ncbi Overuse of acid suppression therapy in hospitalized patients
    Ruchi Gupta
    Department of Medicine and Division of Gastroenterology, University of Florida College of Medicine Center Jacksonville, Jacksonville, FL, USA
    South Med J 103:207-11. 2010
    Acid suppression therapy (AST) is one of the most commonly prescribed classes of medications in hospitalized patients. Multiple studies have shown that AST is overused during inpatient admissions...
  81. ncbi Descriptive analysis of a clinical pharmacy intervention to improve the appropriate use of stress ulcer prophylaxis in a hospital infectious disease ward
    Hossein Khalili
    Department of Clinical Pharmacy, Tehran University of Medical Sciences, Enghelab Ave, Tehran 1417614411, Iran
    J Manag Care Pharm 16:114-21. 2010
    ..In recent years, use of acid suppression therapy (AST) for stress ulcer prophylaxis (SUP) in inpatient settings other than intensive care has become increasingly common, ..
  82. ncbi [Spectroscopic investigation on the interaction between astragalin from lotus leaf and DNA]
    Sheng Guo Deng
    State Key Lab of Food Science and Technology, Institute for Advanced Study, Nanchang University, Nanchang 330047, China
    Guang Pu Xue Yu Guang Pu Fen Xi 30:476-80. 2010
    The interaction between astragalin (AST) from lotus leaf and deoxyribonucleic acid (DNA) in Tris-HCl buffer (pH = 7...
  83. ncbi Reduction in physician reimbursement and use of hormone therapy in prostate cancer
    Sean P Elliott
    Department of Urologic Surgery, University of Minnesota, 420 Delaware St SE, MMC 394, Minneapolis, MN 55455, USA
    J Natl Cancer Inst 102:1826-34. 2010
    Use of androgen suppression therapy (AST) in prostate cancer increased more than threefold from 1991 to 1999...
  84. ncbi Cloning, characterisation and heterologous expression of an astacin metalloprotease, Sc-AST, from the entomoparasitic nematode Steinernema carpocapsae
    Yingjun Jing
    CIRN and Department of Biology, University of Azores, Ponta Delgada, Azores, Portugal
    Mol Biochem Parasitol 174:101-8. 2010
    ..motif and a methionine turn motif; therefore, this protein was identified as an astacin and designated as Sc-AST. The astacin domain of Sc-AST has an amino acid sequence homology of 46% to prototypical astacin from Astacus ..
  85. ncbi Genomic analysis reveals Nairobi sheep disease virus to be highly diverse and present in both Africa, and in India in the form of the Ganjam virus variant
    Pragya D Yadav
    Microbial Containement Complex, National Institute of Virology, Sus Road, Pashan, Pune 410021, India
    Infect Genet Evol 11:1111-20. 2011
    Nairobi sheep disease (NSD) virus, the prototype tick-borne virus of the genus Nairovirus, family Bunyaviridae is associated with acute hemorrhagic gastroenteritis in sheep and goats in East and Central Africa...
  86. ncbi Clinical significance of Aspergillus sensitisation in bronchial asthma
    Ritesh Agarwal
    Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Mycoses 54:e531-8. 2011
    ..study, patients with asthma were subjected to pulmonary function test and an intradermal Aspergillus skin test (AST) apart from a detailed clinical history and physical examination...
  87. ncbi Effects of bone and mineral metabolism on arterial elasticity in chronic renal failure
    Eva Kis
    First Department of Pediatrics, Semmelweis University, Budapest Bókay János u 53 54, 1083, Hungary
    Pediatr Nephrol 24:2413-20. 2009
    Arterial stiffness (Ast) individually predicts cardiovascular (CV) mortality. Ast increases via vascular calcification and can be characterized by pulse wave velocity (PWV)...
  88. ncbi [Therapeutic effects of emodin on acute cholestatic hepatitis and mechanism thereof: experiment with rats]
    Yan Ding
    Department of Gastroenterology and Hepatology, Medical and Health Center for Women and Children, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China
    Zhonghua Yi Xue Za Zhi 89:699-703. 2009
    ..To investigate the therapeutic effects of emodin on acute cholestatic hepatitis and mechanism thereof...
  89. ncbi [Effect of oral adsorbent AST-120 under standard treatment of care in patients with chronic renal failure]
    Izumi Yoshida
    Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Nihon Jinzo Gakkai Shi 51:121-9. 2009
    Oral adsorbent AST-120 reduces uremic toxins, such as indoxyl sulfate, and retards the progression of chronic kidney disease (CKD)...
  90. ncbi Alcohol intake, alcohol dehydrogenase genotypes, and liver damage and disease in the Danish general population
    Janne S Tolstrup
    Center for Alcohol Research, National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
    Am J Gastroenterol 104:2182-8. 2009
    ..We tested the hypothesis that alcohol, alone and in combination with alcohol dehydrogenase (ADH) 1B and ADH1C genotypes, affects liver damage and disease in the general population...
  91. ncbi FGLamide Allatostatin genes in Arthropoda: introns early or late?
    Francisco Martínez-Pérez
    Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
    Peptides 30:1241-8. 2009
    ..The FGLamide allatostatin (AST) gene structure in Dictyoptera is intronless within the ORF, whereas in 9 species of Diptera, the FGLamide AST ORF ..
  92. ncbi Free sialic acid storage disease without sialuria
    Fanny Mochel
    Institut National de la Sante et de la Recherche Médicale UMR S679, Hopital La Salpetriere, Paris, France
    Ann Neurol 65:753-7. 2009
    ..Both patients were homozygous for the K136E mutation in SLC17A5, the gene responsible for the free sialic acid storage diseases...
  93. ncbi Pediatric FAST and elevated liver transaminases: An effective screening tool in blunt abdominal trauma
    Juan E Sola
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Florida, USA
    J Surg Res 157:103-7. 2009
    ..We sought to determine if the focused assessment with sonography for trauma (FAST) combined with elevated liver transaminases (AST/ALT) could be used as a screening tool for intra-abdominal injury (IAI) in pediatric patients with BAT.
  94. ncbi Prenatal screening of sialic acid storage disease and confirmation in cultured fibroblasts by LC-MS/MS
    Jeroen van den Bosch
    Department Clinical Genetics, Erasmus Medical Center, Dr Molewaterplein 50, 3015GE, Rotterdam, The Netherlands
    J Inherit Metab Dis 34:1069-73. 2011
    b>Sialic acid storage disease (SASD) is an inborn error resulting from defects in the lysosomal membrane protein sialin...
  95. ncbi Validation of three non-invasive markers in assessing the severity of liver fibrosis in chronic hepatitis C
    Samiullah Shaikh
    Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Hyderabad
    J Coll Physicians Surg Pak 19:478-82. 2009
    To compare various biochemical markers i.e. APRI (AST to platelet ratio index), aspartate aminotransferase (AST) alanine aminotransferase (ALT) ratio, FIB-4 (AST, platelet, AST and age) with biopsy for assessing the severity of hepatic ..
  96. ncbi Salt-induced cardiac hypertrophy and interstitial fibrosis are due to a blood pressure-independent mechanism in Wistar rats
    Daniele N Ferreira
    Laboratory of Experimental Hypertension, University of Sao Paulo, Sao Paulo 01246 903, Brazil
    J Nutr 140:1742-51. 2010
    ..To better understand this effect, male Wistar rats were fed a normal (NSD: 1.3% NaCl), high 4 (HSD4: 4%), or high 8 (HSD8: 8%) salt diet from weaning until 18 wk of age...
  97. ncbi Reaction product inactivation of aryl sulfotransferase IV following electrophilic substitution by the sulfuric acid ester of N-hydroxy-2-acetylaminofluorene
    D P Ringer
    Samuel Roberts Noble Foundation, Inc, Biomedical Division, Ardmore, OK 73402
    Carcinogenesis 13:107-12. 1992
    ..N-hydroxy-2-acetylaminofluorene (N-OH-2AAF) sulfotransferase activity is mediated by aryl sulfotransferase IV (AST IV) and causes the bioactivation of N-OH-2AAF to a highly reactive sulfuric acid ester form putatively capable of ..
  98. ncbi Predictive factors for sustained response to interferon treatment in patients with chronic hepatitis C: a randomized, open, and multi-center controlled trial
    Yao Xie
    Ninth Clinical Department, Beijing Ditan Hospital, Beijing 100011, China
    Hepatobiliary Pancreat Dis Int 4:213-9. 2005
    ....
  99. ncbi Functional characterization of wild-type and mutant human sialin
    Pierre Morin
    CNRS UPR 1929, Institut de Biologie Physico Chimique, Paris, France
    EMBO J 23:4560-70. 2004
    ..a membrane transporter, named sialin, which is defective in two allelic inherited diseases: infantile sialic acid storage disease (ISSD) and Salla disease...
  100. ncbi 6-month androgen suppression plus radiation therapy vs radiation therapy alone for patients with clinically localized prostate cancer: a randomized controlled trial
    Anthony V D'Amico
    Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, Mass 02215, USA
    JAMA 292:821-7. 2004
    ..in the management of high-grade clinically localized prostate cancer has been shown for 70 Gy radiation therapy combined with 3 years of androgen suppression therapy (AST), but long-term AST is associated with many adverse events.
  101. ncbi Sialin expression in the CNS implicates extralysosomal function in neurons
    Nina Aula
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, 00290 Helsinki, Finland
    Neurobiol Dis 15:251-61. 2004
    ..in sialin result in neurodegenerative sialic acid storage disorders, Salla disease (SD) and infantile sialic acid storage disease (ISSD)...

Research Grants63

  1. Relationship of metabolic abnormalities to hepatic steatosis in HIV
    Richard Sterling; Fiscal Year: 2007
    ..In our HIV population without HCV or HBV, there is a higher prevalence of abnormal liver enzymes (AST 21%, ALT 16%, ALP 43%) compared to the general population (ALT 8%) and is independently associated with PI use...
  2. Role of 5-alpha Reductase in Testosterone Actions
    Shalendar Bhasin; Fiscal Year: 2007
    ..For safety, we will follow hemoglobin/hematocrit, sleep apnea scores, AST and ALT, PSA, plasma lipids, apolipoproteins, and lipoprotein particles, and prostate examinations...
  3. High resolution functional MRI of columnar structures
    Ravi Menon; Fiscal Year: 2007
    ..The techniques we will use to accomplish this are fMRI (BOLD and AST based), electrophysiology, fluorescence quenching, laser Doppler and near-infrared spectroscopy at high spatial and ..
  4. Avoiding toxicity associated with MTP ablation
    M Mahmood Hussain; Fiscal Year: 2010
    ..However, they increase plasma aminotransferases, such as ALT and AST, indicating liver injury...
  5. Pontine Control of REM Atonia
    Elda Arrigoni; Fiscal Year: 2010
    ..Considerable evidence demonstrates that neurons of the sublaterodorsal (SLD) nucleus of the pons, also known as the subcoreuleus, generate muscle atonia during REM sleep...
  6. Pontine Control of REM Atonia
    Elda Arrigoni; Fiscal Year: 2009
    ..Considerable evidence demonstrates that neurons of the sublaterodorsal (SLD) nucleus of the pons, also known as the subcoreuleus, generate muscle atonia during REM sleep...
  7. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2005
    ..For safety, we will follow hematocrit, AST and ALT, PSA, plasma lipids, apolipoproteins, and lipoprotein particles, digital rectal examinations, and sleep ..
  8. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2004
    ..For safety, we will follow hemoglobin/hematocrit, AST and ALT, PSA, plasma lipids, apolipoproteins, and lipoprotein particles, and insulin sensitivity by the modified ..
  9. Alcohol & Antiretrovirals in HIV Infection, Oxidative Stress and Liver Disease
    Marianna K Baum; Fiscal Year: 2010
    ..Hepatocellular injury and function will be determined with plasma levels of ALT, AST, platelets, albumin, hyaluronic acid and total and conjugated bilirubin...
  10. Pontine circuitry regulating REM sleep and atonia
    Jun Lu; Fiscal Year: 2009
    ..In this flip-flop switch arrangement, GABAergic REM-on neurons (located in the sublateraldorsal tegmental nucleus (SLD)) inhibit GABAergic REM-off neurons (located in the ventrolateral periaqueductal gray matter (vlPAG) and lateral ..
  11. Genetic and Ecological Factors in Transmissibility and Epidemic Cycle of Cholera
    JOHN JOSEPH MEKALANOS; Fiscal Year: 2010
    ..We will apply a new method we developed called AST to monitor and study the nature of "conditionally viable environmental cells (CVEC)" of pathogenic V...
  12. Nonalcoholic fatty liver disease in Hispanic obese youth
    Nancy Butte; Fiscal Year: 2005
    ..and hyperleptinemia, and elevations in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). 3...