SLC16A7

Summary

Gene Symbol: SLC16A7
Description: solute carrier family 16 member 7
Alias: MCT2, monocarboxylate transporter 2, solute carrier family 16 (monocarboxylate transporter), member 7, solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
Species: human
Products:     SLC16A7

Top Publications

  1. Wang Q, Morris M. The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells. Drug Metab Dispos. 2007;35:1393-9 pubmed
    ..The objective of this study was to investigate the role of MCT2 and MCT4, present in tissues including intestine, kidney, skeletal muscle, and brain, in the membrane transport of ..
  2. Pinheiro C, Reis R, Ricardo S, Longatto Filho A, Schmitt F, Baltazar F. Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44. J Biomed Biotechnol. 2010;2010:427694 pubmed publisher
    ..In the present study, we analysed MCT1, MCT2, and MCT4 protein expression in breast, colon, lung, and ovary neoplasms, as well as CD147 and CD44...
  3. Wilson M, Meredith D, Fox J, Manoharan C, Davies A, Halestrap A. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem. 2005;280:27213-21 pubmed
    ..b>MCT2, which is pCMBS-insensitive, was found to co-immunoprecipitate with gp70 rather than CD147...
  4. Pinheiro C, Longatto Filho A, Scapulatempo C, Ferreira L, Martins S, Pellerin L, et al. Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas. Virchows Arch. 2008;452:139-46 pubmed publisher
    ..CRC samples (126 cases) were analyzed for MCT1, MCT2, and MCT4 immunoexpression and findings correlated with clinico-pathological parameters...
  5. Halestrap A, Meredith D. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch. 2004;447:619-28 pubmed
    ..The properties of the different MCT isoforms and their tissue distribution and regulation reflect these roles. ..
  6. Pérez de Heredia F, Wood I, Trayhurn P. Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes. Pflugers Arch. 2010;459:509-18 pubmed publisher
    ..Screening by reverse transcription polymerase chain reaction indicated that the genes encoding MCT1, MCT2, and MCT4 are expressed in human adipose tissue, and in adipocytes and preadipocytes in culture...
  7. Chen J, Su Q, Qin J, Zhou Y, Ruan H, Chen Z, et al. Correlation of MCT1 and ABCC2 gene polymorphisms with valproic acid resistance in patients with epilepsy on valproic acid monotherapy. Drug Metab Pharmacokinet. 2018;: pubmed publisher
    ..Twelve SNPs involved in VPA transport pathways, including ABCC2, ABCC4, ABCG2, MCT1, MCT2 and OATP2B1 were genotyped in 153 Han Chinese epilepsy patients...
  8. Afonso J, Pinto T, Simões Sousa S, Schmitt F, Longatto Filho A, Pinheiro C, et al. Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma. Cell Oncol (Dordr). 2019;: pubmed publisher
    ..We assessed, by immunohistochemistry, the expression of the metabolism-related molecules MCT1, MCT2, MCT4, CD147, GLUT1, LDHA and CAIX in both tumour and stroma compartments of tissue sections obtained from 104 NHL ..
  9. Ibrahim B, Briski K. Role of dorsal vagal complex A2 noradrenergic neurons in hindbrain glucoprivic inhibition of the luteinizing hormone surge in the steroid-primed ovariectomized female rat: effects of 5-thioglucose on A2 functional biomarker and AMPK activity. Neuroscience. 2014;269:199-214 pubmed publisher
    ..Intriguingly, A2 AMPK activity was decreased in 5TG-treated rats, despite down-regulation of GLUT3 and no change in MCT2 protein expression...

More Information

Publications85

  1. Jahangiri Z, Gholamnezhad Z, Hosseini M. Neuroprotective effects of exercise in rodent models of memory deficit and Alzheimer's. Metab Brain Dis. 2019;34:21-37 pubmed publisher
    ..and suppress apoptosis in dentate gyrus; increase in brain-derived neurotrophic factor and tropomyosin receptor kinase B expressions; enhancing the glycogen levels and normalizing the monocarboxylate transporter 2 expression.
  2. Forero Quintero L, Ames S, Schneider H, Thyssen A, Boone C, Andring J, et al. Membrane-anchored carbonic anhydrase IV interacts with monocarboxylate transporters via their chaperones CD147 and GP70. J Biol Chem. 2019;294:593-607 pubmed publisher
    ..The transport activity of MCT1, MCT2, and MCT4 can be facilitated by the extracellular carbonic anhydrase IV (CAIV) via a noncatalytic mechanism...
  3. Yadav S, Pandey A, Kumar L, Devi A, Kushwaha B, Vishvkarma R, et al. The thermo-sensitive gene expression signatures of spermatogenesis. Reprod Biol Endocrinol. 2018;16:56 pubmed publisher
    ..5 fold, out of which 6 were common to both the cell types. The study has identified Acly, selV, SLC16A7(MCT-2), Txnrd1 and Prkar2B as potential heat sensitive targets in germ cells, which may be tightly regulated by ..
  4. Chen K, Cheng P, Wang H, Gao S, Li X, Deng Z, et al. Lactate transport facilitates neurite outgrowth. Biosci Rep. 2018;38: pubmed publisher
    ..Our results suggested that lactate transportation played a critical role in neural development and disruption of the lactate shuttle in quiescent condition also affected neurite outgrowth in the central nervous system. ..
  5. Fets L, Driscoll P, Grimm F, Jain A, Nunes P, Gounis M, et al. MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG. Nat Chem Biol. 2018;14:1032-1042 pubmed publisher
    ..MOG elicits cytotoxicity in a manner that depends on its transport by monocarboxylate transporter 2 (MCT2) and is associated with decreased glutamine-derived tricarboxylic acid-cycle flux, suppressed ..
  6. Kirat D, Kato S. The monocarboxylate transporters exist in the cattle endocrine pancreas. Histochem Cell Biol. 2015;143:185-94 pubmed publisher
    ..RT-PCR verified the existence of mRNA transcripts for eight MCT isoforms, namely, MCT1, MCT2, MCT3, MCT4, MCT5, MCT8, MCT13, and MCT14 in cattle pancreas...
  7. Jung D, Kim J, Kim C, Song S. Embigin is overexpressed in pancreatic ductal adenocarcinoma and regulates cell motility through epithelial to mesenchymal transition via the TGF-β pathway. Mol Carcinog. 2016;55:633-45 pubmed publisher
    ..analysis revealed expression of Embigin in pancreatic cancer cells, as well as expression of monocarboxylate transporter 2 (MCT2) in cancer tissues...
  8. Gao C, Zhou L, Zhu W, Wang H, Wang R, He Y, et al. Monocarboxylate transporter-dependent mechanism confers resistance to oxygen- and glucose-deprivation injury in astrocyte-neuron co-cultures. Neurosci Lett. 2015;594:99-104 pubmed publisher
    ..Cell survival and expression of MCT4, MCT2, glial fibrillary acidic protein, and neuronal nuclear antigen were evaluated...
  9. Heidtmann H, Ruminot I, Becker H, Deitmer J. Inhibition of monocarboxylate transporter by N-cyanosulphonamide S0859. Eur J Pharmacol. 2015;762:344-9 pubmed publisher
    ..The activity of monocarboxylate transporter (MCT) isoforms 1, 2, and 4 (SLC16A1, SLC16A7, SLC16A3), which transport lactate, pyruvate and ketone bodies, were also heterologously expressed in Xenopus ..
  10. Miyahara N, Kokubo T, Hara Y, Yamada A, Koike T, Arai Y. Evaluation of X-ray doses and their corresponding biological effects on experimental animals in cone-beam micro-CT scans (R-mCT2). Radiol Phys Technol. 2016;9:60-8 pubmed publisher
    ..Therefore, it is unlikely that the measured doses for the CT scans caused any radiation damage in the mice. ..
  11. Molnar B, Galamb O, Péterfia B, Wichmann B, Csabai I, Bodor A, et al. Gene promoter and exon DNA methylation changes in colon cancer development - mRNA expression and tumor mutation alterations. BMC Cancer. 2018;18:695 pubmed publisher
    ..differential methylated regions (DMRs), in AD-N comparison TP73, NGFR, PDGFRA genes were hypermethylated, FMN1, SLC16A7 genes were hypomethylated...
  12. Domènech Estévez E, Baloui H, Repond C, Rosafio K, Médard J, Tricaud N, et al. Distribution of monocarboxylate transporters in the peripheral nervous system suggests putative roles in lactate shuttling and myelination. J Neurosci. 2015;35:4151-6 pubmed publisher
    ..Here we show that mouse MCT1, MCT2, and MCT4 are expressed in the PNS...
  13. Noor S, Dietz S, Heidtmann H, Boone C, McKenna R, Deitmer J, et al. Analysis of the binding moiety mediating the interaction between monocarboxylate transporters and carbonic anhydrase II. J Biol Chem. 2015;290:4476-86 pubmed publisher
    ..II augments transport activity of MCT1 and MCT4 by a noncatalytic mechanism, while leaving transport activity of MCT2 unaltered...
  14. Schutkowski A, Wege N, Stangl G, König B. Tissue-specific expression of monocarboxylate transporters during fasting in mice. PLoS ONE. 2014;9:e112118 pubmed publisher
    ..Expression of MCT1, MCT2 and MCT10 was either increased or decreased by fasting dependent on the analyzed tissue...
  15. Girum K, Lalande A, Quivrin M, Bessières I, Pierrat N, Martin E, et al. Inferring postimplant dose distribution of salvage permanent prostate implant (PPI) after primary PPI on CT images. Brachytherapy. 2018;17:866-873 pubmed publisher
    ..The detected primary seeds on CT1 and CT2 were registered and then removed from CT2 referred as a modified CT2 (mCT2)...
  16. Shrestha P, Briski K. Hindbrain lactate regulates preoptic gonadotropin-releasing hormone (GnRH) neuron GnRH-I protein but not AMPK responses to hypoglycemia in the steroid-primed ovariectomized female rat. Neuroscience. 2015;298:467-74 pubmed publisher
    ..Fos, estrogen receptor-beta (ER-β), phosphoAMPK (pAMPK)] and inhibition (dopamine-beta-hydroxylase, GLUT3, MCT2) of protein expression in these cells, responses that were normalized by insulin plus lactate treatment...
  17. Lund J, Aas V, Tingstad R, Van Hees A, Nikolić N. Utilization of lactic acid in human myotubes and interplay with glucose and fatty acid metabolism. Sci Rep. 2018;8:9814 pubmed publisher
    ..Myotubes expressed both the MCT1, MCT2, MCT3 and MCT4 lactate transporters, and lactic acid was found to be a substrate for both glycogen synthesis and ..
  18. Eilertsen M, Andersen S, Al Saad S, Kiselev Y, Donnem T, Stenvold H, et al. Monocarboxylate transporters 1-4 in NSCLC: MCT1 is an independent prognostic marker for survival. PLoS ONE. 2014;9:e105038 pubmed publisher
    ..021) and ↑ MCT4 (P = 0.027) expression in cancer cells, and ↑ MCT1 (P = 0.003), ↓ MCT2 (P = 0.006), ↓ MCT3 (P = 0.020) expression in stromal cells correlated significantly with a poor DSS...
  19. Lee J, Lee I, Chang W, Ahn S, Lim S, Kim H, et al. MCT4 as a potential therapeutic target for metastatic gastric cancer with peritoneal carcinomatosis. Oncotarget. 2016;7:43492-43503 pubmed publisher
    ..with different expression levels; MCT1 and MCT4 were more widely expressed in GC cell lines compared with MCT2. Inhibition of MCTs by siRNA or AR-C155858 reduced cell viability and lactate uptake in GC cell lines...
  20. Lopes E, Marques L, Duranti R, de Oliveira A, Lopes R, Rodrigues J. Gene Expression of Monocarboxylate Transporters and Oocyte-secreted Factors in Bovine Cumulus-oocyte Complexes Selected by Brilliant Cresyl Blue. Reprod Domest Anim. 2015;50:763-70 pubmed publisher
    ..Mct1 and Mct4 transcripts were present in denuded oocytes and cumulus cell, while Mct2 was detected only in cumulus cells...
  21. Perkins M, Wolf A, Chavira B, Shonebarger D, Meckel J, Leung L, et al. Altered Energy Metabolism Pathways in the Posterior Cingulate in Young Adult Apolipoprotein E ?4 Carriers. J Alzheimers Dis. 2016;53:95-106 pubmed publisher
    ..Young adult APOE4 carriers displayed upregulation of specific glucose (GLUT1 & GLUT3) and monocarboxylate (MCT2) transporters, the glucose metabolism enzyme hexokinase, the SCOT & AACS enzymes involved in ketone metabolism, ..
  22. Shima T, Jesmin S, Matsui T, Soya M, Soya H. Differential effects of type 2 diabetes on brain glycometabolism in rats: focus on glycogen and monocarboxylate transporter 2. J Physiol Sci. 2018;68:69-75 pubmed publisher
    ..lactate shuttle (ANLS) is a pathway that supplies glycogen-derived lactate to active neurons via monocarboxylate transporter 2 (MCT2), and is important for maintaining brain functions...
  23. Chen C, Maekawa M, Yamatoya K, Nozaki M, Ito C, Iwanaga T, et al. Interaction between basigin and monocarboxylate transporter 2 in the mouse testes and spermatozoa. Asian J Androl. 2016;18:600-6 pubmed publisher
    ..is known to be a chaperone for the monocarboxylate transporter 1 (MCT1), the localization of basigin, MCT1 and MCT2 was examined during postnatal testicular development...
  24. Pinheiro C, Granja S, Longatto Filho A, Faria A, Fragoso M, Lovisolo S, et al. Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors. Oncotarget. 2015;6:44403-21 pubmed publisher
    ..The immunohistochemical expression of MCT1, MCT2, MCT4, CD147, CD44, GLUT1 and CAIX was evaluated in a series of 154 adult patients with adrenocortical neoplasia ..
  25. Shima T, Matsui T, Jesmin S, Okamoto M, Soya M, Inoue K, et al. Moderate exercise ameliorates dysregulated hippocampal glycometabolism and memory function in a rat model of type 2 diabetes. Diabetologia. 2017;60:597-606 pubmed publisher
    ..However, OLETF rats expressed lower levels of hippocampal monocarboxylate transporter 2 (MCT2, a transporter for lactate to neurons)...
  26. Angamo E, Rösner J, Liotta A, Kovacs R, Heinemann U. A neuronal lactate uptake inhibitor slows recovery of extracellular ion concentration changes in the hippocampal CA3 region by affecting energy metabolism. J Neurophysiol. 2016;116:2420-2430 pubmed publisher
    ..acid (4-CIN), which could interfere with energy metabolism by blocking monocarboxylate-transporter 2 (MCT2)-mediated neuronal lactate uptake, on evoked potentials, stimulus-induced changes in K+, Na+, ..
  27. Rosafio K, Castillo X, Hirt L, Pellerin L. Cell-specific modulation of monocarboxylate transporter expression contributes to the metabolic reprograming taking place following cerebral ischemia. Neuroscience. 2016;317:108-20 pubmed publisher
    ..73 ± 0.2 and contralateral 2.01 ± 0.4; MCT2 ipsilateral 2.1 ± 0.1; MCT4 ipsilateral 1.65 ± 0...
  28. Forero Quintero L, Deitmer J, Becker H. Reduction of epileptiform activity in ketogenic mice: The role of monocarboxylate transporters. Sci Rep. 2017;7:4900 pubmed publisher
    ..Inhibition of MCT1 and MCT2 in control conditions decreases epileptiform activity, while in KD it induced an increase in epileptiform activity...
  29. Hoshino D, Setogawa S, Kitaoka Y, Masuda H, Tamura Y, Hatta H, et al. Exercise-induced expression of monocarboxylate transporter 2 in the cerebellum and its contribution to motor performance. Neurosci Lett. 2016;633:1-6 pubmed publisher
    b>Monocarboxylate transporter 2 (MCT2) is an important component of the lactate transport system in neurons of the adult brain...
  30. Silva V, Secolin R, Vemuganti R, Lopes Cendes I, Hazell A. Acute liver failure is associated with altered cerebral expression profiles of long non-coding RNAs. Neurosci Lett. 2017;656:58-64 pubmed publisher
    ..upregulated lncRNAs, 2 of which are associated with neuroepithelial transforming gene 1 (NET1) and the monocarboxylate transporter 2 (Slc16a7), potential contributors to astrocyte cytoskeletal disruption/swelling and lactate production,..
  31. Caruso J, Koch B, Benson P, Varughese E, Monterey M, Lee A, et al. pH, Lactate, and Hypoxia: Reciprocity in Regulating High-Affinity Monocarboxylate Transporter Expression in Glioblastoma. Neoplasia. 2017;19:121-134 pubmed publisher
    ..One isoform, MCT2, has the highest affinity for lactate and thus should have the ability to respond to microenvironment conditions ..
  32. Huang C, Chang P, Kuo W, Chen C, Jeng Y, Chang K, et al. Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate. Nat Commun. 2017;8:14706 pubmed publisher
    ..primary mammary gland-derived adipocytes (MGDAs) promote growth of breast cancer cells that express monocarboxylate transporter 2 (MCT2) both in vitro and in vivo...
  33. Kropp J, Carrillo J, Namous H, Daniels A, Salih S, Song J, et al. Male fertility status is associated with DNA methylation signatures in sperm and transcriptomic profiles of bovine preimplantation embryos. BMC Genomics. 2017;18:280 pubmed publisher
    ..Expression of the genes CYCS, EEA1, SLC16A7, MEPCE, and TFB2M was validated in three new pairs of biological replicates of embryos...
  34. Ma L, Zhao M, Zhao L, Xu J, Loor J, Bu D. Effects of dietary neutral detergent fiber and starch ratio on rumen epithelial cell morphological structure and gene expression in dairy cows. J Dairy Sci. 2017;100:3705-3712 pubmed publisher
    ..encoding the rate-limiting enzyme in the synthesis of ketone bodies) decreased linearly, whereas the expression of MCT2 (encoding a transporter of volatile fatty acid) increased linearly with increasing dietary neutral detergent fiber ..
  35. Ouyang L, Tian Y, Bao Y, Xu H, Cheng J, Wang B, et al. Carnosine decreased neuronal cell death through targeting glutamate system and astrocyte mitochondrial bioenergetics in cultured neuron/astrocyte exposed to OGD/recovery. Brain Res Bull. 2016;124:76-84 pubmed publisher
    ..The levels of mRNAs for monocarboxylate transporter1, 4 (MCT1, 4), which were expressed in astrocytes, and MCT2, the main neuronal MCT, were significantly increased at the early stage of recovery...
  36. Nonose Y, Gewehr P, Almeida R, da Silva J, Bellaver B, Martins L, et al. Cortical Bilateral Adaptations in Rats Submitted to Focal Cerebral Ischemia: Emphasis on Glial Metabolism. Mol Neurobiol. 2018;55:2025-2041 pubmed publisher
    ..In the intact hemisphere, there was a decrease in MCT2 levels, which did not persist...
  37. Takechi T, Hirota T, Sakai T, Maeda N, Kobayashi D, Ieiri I. Interindividual Differences in the Expression of ATP-Binding Cassette and Solute Carrier Family Transporters in Human Skin: DNA Methylation Regulates Transcriptional Activity of the Human ABCC3 Gene. Drug Metab Dispos. 2018;46:628-635 pubmed publisher
    ..In skin samples, ABCC3 was expressed at the highest levels, followed by SLCO3A1, SLC22A3, SLC16A7, ABCA2, ABCC1, and SLCO2B1. Among the quantitated transporters, ABCC3 accounted for 20...
  38. Solís Maldonado M, Miró M, Acuña A, Covarrubias Pinto A, Loaiza A, Mayorga G, et al. Altered lactate metabolism in Huntington's disease is dependent on GLUT3 expression. CNS Neurosci Ther. 2018;24:343-352 pubmed publisher
    ..Functional analyses revealed that neuronal MCT2 had a high catalytic efficiency in HD cells. Ascorbic acid did not stimulate lactate uptake in HD cells...
  39. Kong S, Nøhr Nielsen A, Zeeberg K, Reshkin S, Hoffmann E, Novak I, et al. Monocarboxylate Transporters MCT1 and MCT4 Regulate Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells. Pancreas. 2016;45:1036-47 pubmed publisher
    ..cells and lowest in HPDE cells and was inhibited by the MCT inhibitor α-cyano-4-hydroxycinnamate (4-CIN), MCT1/MCT2 inhibitor AR-C155858, or knockdown of MCT1 or MCT4...
  40. Nancolas B, Guo L, Zhou R, Nath K, Nelson D, Leeper D, et al. The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters. Biochem J. 2016;473:929-36 pubmed publisher
    ..5 μM) and co-operatively inhibits L-lactate transport by MCT1, MCT2 and MCT4 expressed in Xenopus laevisoocytes with K0.5 and Hill coefficient values of 36-40 μM and 1.65-1...
  41. Mazuel L, Blanc J, Repond C, Bouchaud V, Raffard G, Déglon N, et al. A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation. PLoS ONE. 2017;12:e0174990 pubmed publisher
    ..a short hairpin RNA (shRNA) was used to downregulate the expression of the monocarboxylate transporter type 2 (MCT2) in neurons of the rat somatosensory cortex (called S1BF) by ~ 25%...
  42. Kirat D, Shousha S. Angiotensin II up-regulates monocarboxylate transporters expression in the rat adrenal gland. Cell Mol Biol (Noisy-le-grand). 2016;62:24-9 pubmed
    ..current study aims to investigate the effect of in vivo infusion of Ang II on monocarboxylate transporters (MCT1, MCT2, and MCT4) gene expression in the rat adrenal gland...
  43. Halestrap A. The monocarboxylate transporter family--Structure and functional characterization. IUBMB Life. 2012;64:1-9 pubmed publisher
    ..MCT1, MCT3, and MCT4 bind preferentially to basigin and MCT2 to embigin...
  44. Guo X, Chen C, Liu B, Wu Y, Chen Y, Zhou X, et al. Genetic variations in monocarboxylate transporter genes as predictors of clinical outcomes in non-small cell lung cancer. Tumour Biol. 2015;36:3931-9 pubmed publisher
    ..Nine functional SNPs in MCT1, MCT2, and MCT4 genes were selected and genotyped using Sequenom iPLEX genotyping system in 500 Chinese NSCLC patients ..
  45. Pinheiro C, Granja S, Longatto Filho A, Faria A, Fragoso M, Lovisolo S, et al. GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behavior. Oncotarget. 2017;8:63835-63845 pubmed publisher
    ..The aim of this work is to characterize the expression of the metabolism-related proteins MCT1, MCT2, MCT4, CD147, CD44, GLUT1 and CAIX in a series of pediatric adrenocortical tumors.
  46. Pértega Gomes N, Vizcaíno J, Felisbino S, Warren A, Shaw G, Kay J, et al. Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer. Oncotarget. 2015;6:21675-84 pubmed
    b>Monocarboxylate Transporter 2 (MCT2) is a major pyruvate transporter encoded by the SLC16A7 gene...
  47. Valença I, Pértega Gomes N, Vizcaino J, Henrique R, Lopes C, Baltazar F, et al. Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer. J Cell Mol Med. 2015;19:723-33 pubmed publisher
    Previous studies on monocarboxylate transporters expression in prostate cancer (PCa) have shown that monocarboxylate transporter 2 (MCT2) was clearly overexpressed in prostate malignant glands, pointing it out as a putative biomarker for ..
  48. Chiry O, Fishbein W, Merezhinskaya N, Clarke S, Galuske R, Magistretti P, et al. Distribution of the monocarboxylate transporter MCT2 in human cerebral cortex: an immunohistochemical study. Brain Res. 2008;1226:61-9 pubmed publisher
    The monocarboxylate transporter MCT2 belongs to a large family of membrane proteins involved in the transport of lactate, pyruvate and ketone bodies...
  49. Becker H, Mohebbi N, Perna A, Ganapathy V, Capasso G, Wagner C. Localization of members of MCT monocarboxylate transporter family Slc16 in the kidney and regulation during metabolic acidosis. Am J Physiol Renal Physiol. 2010;299:F141-54 pubmed publisher
    ..Here, we investigated selected members of the MCT family in the mouse kidney. MCT1, MCT2, MCT7, and MCT8 localized to basolateral membranes of the epithelial cells lining the nephron...
  50. Cheng C, Edin N, Lauritzen K, Aspmodal I, Christoffersen S, Jian L, et al. Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells. Cell Oncol (Dordr). 2012;35:217-27 pubmed publisher
    ..cells and human glioblastoma T98G cells were grown under 4 % or 20 % oxygen conditions and examined for MCT1, MCT2 and MCT4 expression on plasma membranes by quantitative post embedding immunogold electron microscopy...
  51. Pértega Gomes N, Vizcaíno J, Miranda Gonçalves V, Pinheiro C, Silva J, Pereira H, et al. Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer. BMC Cancer. 2011;11:312 pubmed publisher
    ..work was to evaluate the clinico-pathological value of monocarboxylate transporters (MCTs) expression, namely MCT1, MCT2 and MCT4, together with CD147 and gp70 as MCT1/4 and MCT2 chaperones, respectively, in prostate carcinoma...
  52. Nath K, Guo L, Nancolas B, Nelson D, Shestov A, Lee S, et al. Mechanism of antineoplastic activity of lonidamine. Biochim Biophys Acta. 2016;1866:151-162 pubmed publisher
    ..5?M) and cooperatively inhibits l-lactate transport by MCT1, MCT2 and MCT4 expressed in Xenopus laevis oocytes with K0.5 and Hill coefficient values of 36-40?M and 1.65-1...
  53. Lin R, Vera J, Chaganti R, Golde D. Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. J Biol Chem. 1998;273:28959-65 pubmed
    ..We have molecularly cloned and characterized a novel human monocarboxylate transporter, MCT2. The cDNA is 1,907 base pairs long and encodes a polypeptide of 478 amino acids with 12 predicted transmembrane ..
  54. Fishbein W, Merezhinskaya N, Foellmer J. Relative distribution of three major lactate transporters in frozen human tissues and their localization in unfixed skeletal muscle. Muscle Nerve. 2002;26:101-12 pubmed
    ..expression patterns for each MCT in a panel of 15 frozen human tissues, with the distribution of MCT1 >MCT2>MCT4...
  55. Fayol L, Baud O, Monier A, Pellerin L, Magistretti P, Evrard P, et al. Immunocytochemical expression of monocarboxylate transporters in the human visual cortex at midgestation. Brain Res Dev Brain Res. 2004;148:69-76 pubmed
    ..We investigated the immunocytochemical expression of two monocarboxylate transporters, MCT1 and MCT2, in the human visual cortex between 13 and 26 post-ovulatory weeks...
  56. Merezhinskaya N, Ogunwuyi S, Mullick F, Fishbein W. Presence and localization of three lactic acid transporters (MCT1, -2, and -4) in separated human granulocytes, lymphocytes, and monocytes. J Histochem Cytochem. 2004;52:1483-93 pubmed
    ..translational expression of three physiologically-proven lactate transporters, monocarboxylate transporter 1(MCT1), MCT2, and MCT4, using RT-PCR and affinity-purified rabbit antibody (Ab) to the C-terminal segment of each human MCT...
  57. Klier M, Schüler C, Halestrap A, Sly W, Deitmer J, Becker H. Transport activity of the high-affinity monocarboxylate transporter MCT2 is enhanced by extracellular carbonic anhydrase IV but not by intracellular carbonic anhydrase II. J Biol Chem. 2011;286:27781-91 pubmed publisher
    ..CA isoform IV (CAIV) on the lactate transport activity of the high-affinity monocarboxylate transporter MCT2, heterologously expressed in Xenopus oocytes...
  58. Li P, Nielsen H, Müllertz A. Impact of Lipid-Based Drug Delivery Systems on the Transport and Uptake of Insulin Across Caco-2 Cell Monolayers. J Pharm Sci. 2016;105:2743-2751 pubmed publisher
    ..that fluorescein isothiocyanate-labeled insulin when administered in solution, as well as when loaded into MCT1 or MCT2 SNEDDS, localized within the intercellular space of the Caco-2 cell monolayer, indicating transport by paracellular ..
  59. Lee I, Lee S, Kang W, Park C. Inhibition of monocarboxylate transporter 2 induces senescence-associated mitochondrial dysfunction and suppresses progression of colorectal malignancies in vivo. Mol Cancer Ther. 2012;11:2342-51 pubmed publisher
    ..In the present study, we show that the monocarboxylate transporter 2 (MCT2) protein was tumor-selectively expressed in human colorectal malignancies and knockdown of MCT2 ..
  60. Vavaiya K, Briski K. Caudal hindbrain lactate infusion alters glucokinase, SUR1, and neuronal substrate fuel transporter gene expression in the dorsal vagal complex, lateral hypothalamic area, and ventromedial nucleus hypothalamus of hypoglycemic male rats. Brain Res. 2007;1176:62-70 pubmed
    ..g., the ventromedial hypothalamic nucleus (VMH) and lateral hypothalamic area (LHA). qPCR was used to measure MCT2, GLUT3, GLUT4, GK, and SUR1 transcripts in the microdissected DVC, VMH, and LHA from groups of male rats treated by ..
  61. Vavaiya K, Briski K. Effects of caudal fourth ventricular lactate infusion on hypoglycemia-associated MCT2, GLUT3, GLUT4, GCK, and sulfonylurea receptor-1 gene expression in the ovariectomized female rat LHA and VMH: impact of estradiol. J Mol Neurosci. 2008;34:121-9 pubmed
    ..Neuronal glucose (GLUT3, GLUT4) and monocarboxylate (MCT2) transporter genes are expressed in both sites, suggesting that glucose and lactate, a product of astrocytic ..
  62. Matsui T, Omuro H, Liu Y, Soya M, Shima T, McEwen B, et al. Astrocytic glycogen-derived lactate fuels the brain during exhaustive exercise to maintain endurance capacity. Proc Natl Acad Sci U S A. 2017;114:6358-6363 pubmed publisher
    ..At exhaustion, muscle glycogen was depleted but brain glycogen was only decreased. The levels of MCT2, which takes up lactate in neurons, increased in the brain, as did muscle MCTs...
  63. Briski K, Cherian A, Genabai N, Vavaiya K. In situ coexpression of glucose and monocarboxylate transporter mRNAs in metabolic-sensitive caudal dorsal vagal complex catecholaminergic neurons: transcriptional reactivity to insulin-induced hypoglycemia and caudal hindbrain glucose or lactate rep. Neuroscience. 2009;164:1152-60 pubmed publisher
    ..The data show that IIH decreased MCT2, but elevated GLUT3, GLUT4, GCK, and SUR-1 transcripts in A2 neurons...
  64. Cherian A, Briski K. Effects of adrenalectomy on neuronal substrate fuel transporter and energy transducer gene expression in hypothalamic and hindbrain metabolic monitoring sites. Neuroendocrinology. 2010;91:56-63 pubmed publisher
    ..injection, and evaluated by quantitative real-time RT-PCR for neuronal glucose (GLUT3, GLUT4), monocarboxylate (MCT2) transporter, GCK, and sulfonylurea receptor-1 (SUR1) mRNA content...
  65. Lauritzen F, Heuser K, de Lanerolle N, Lee T, Spencer D, Kim J, et al. Redistribution of monocarboxylate transporter 2 on the surface of astrocytes in the human epileptogenic hippocampus. Glia. 2012;60:1172-81 pubmed publisher
    ..astrocyte endfeet comprise an important part of the neurovascular unit, we now assessed the distribution of the MCT2 in hippocampal formations in TLE patients with (MTLE) or without hippocampal sclerosis (non-MTLE)...
  66. Curtis N, Mooney L, Hopcroft L, Michopoulos F, Whalley N, Zhong H, et al. Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt's lymphoma anti-tumor activity. Oncotarget. 2017;8:69219-69236 pubmed publisher
    ..AZD3965 is a potent inhibitor of MCT1 with activity against MCT2 but selectivity over MCT3 and MCT4...
  67. Moncrieffe H, Hinks A, Ursu S, Kassoumeri L, Etheridge A, Hubank M, et al. Generation of novel pharmacogenomic candidates in response to methotrexate in juvenile idiopathic arthritis: correlation between gene expression and genotype. Pharmacogenet Genomics. 2010;20:665-76 pubmed publisher
    ..Three SNPs in the SLC16A7 gene showed significant association with MTX response...
  68. Chen C, Liao Y, Lin S, Yu J, Li Z, Lin Y, et al. Diet-induced obesity accelerates blood lactate accumulation of rats in response to incremental exercise to maximum. Am J Physiol Regul Integr Comp Physiol. 2017;313:R601-R607 pubmed publisher
    ..Animals with HFD had a decreased level of hepatic monocarboxylate transporter 2, the protein responsible for blood lactate uptake in the liver...
  69. Hussien R, Brooks G. Mitochondrial and plasma membrane lactate transporter and lactate dehydrogenase isoform expression in breast cancer cell lines. Physiol Genomics. 2011;43:255-64 pubmed publisher
    ..When present in HMEC 184 and MCF-7 cells, MCT1 is localized to the plasma membrane. MCT2 and MCT4 were expressed in all the cell lines studied...
  70. Chen C, Zhang C, Cheng L, Reilly J, Bishop J, Sweeney J, et al. Correlation between DNA methylation and gene expression in the brains of patients with bipolar disorder and schizophrenia. Bipolar Disord. 2014;16:790-9 pubmed publisher
    ..subfamily 3, member A3 (BTN3A3), nescient helix-loop-helix 1 (NHLH1), and solute carrier family 16, member 7 (SLC16A7) in psychotic patients (p < 0.05, FDR q < 0.2)...
  71. Fei F, Guo X, Chen Y, Liu X, Tu J, Xing J, et al. Polymorphisms of monocarboxylate transporter genes are associated with clinical outcomes in patients with colorectal cancer. J Cancer Res Clin Oncol. 2015;141:1095-102 pubmed publisher
    ..Nine functional SNPs in three MCT genes (MCT1, MCT2 and MCT4) were selected and genotyped using Sequenom iPLEX genotyping system in 697 Chinese CRC patients receiving ..
  72. Cori C. The glucose-lactic acid cycle and gluconeogenesis. Curr Top Cell Regul. 1981;18:377-87 pubmed
  73. Dai Y, Zhao Y, Tomi M, Shin B, Thamotharan S, Mazarati A, et al. Sex-Specific Life Course Changes in the Neuro-Metabolic Phenotype of Glut3 Null Heterozygous Mice: Ketogenic Diet Ameliorates Electroencephalographic Seizures and Improves Sociability. Endocrinology. 2017;158:936-949 pubmed publisher
    ..female mice (5 months of age) displayed reduced CSF glucose/lactate concentrations with no change in brain Glut1, Mct2, glucose uptake or ATP...
  74. Pértega Gomes N, Vizcaíno J, Gouveia C, Jeronimo C, Henrique R, Lopes C, et al. Monocarboxylate transporter 2 (MCT2) as putative biomarker in prostate cancer. Prostate. 2013;73:763-9 pubmed publisher
    b>Monocarboxylate transporter 2 (MCT2) is a transmembrane protein involved in the transport of monocarboxylates such as pyruvate and lactate...
  75. Vellonen K, Hakli M, Merezhinskaya N, Tervo T, Honkakoski P, Urtti A. Monocarboxylate transport in human corneal epithelium and cell lines. Eur J Pharm Sci. 2010;39:241-7 pubmed publisher
    ..Monocarboxylate transport was functional in the human corneal epithelial cells and rabbit cornea and it may play a role in the ocular drug absorption...
  76. Lee J, Lee D, Lee S. The genetic variation in monocarboxylic acid transporter 2 (MCT2) has functional and clinical relevance with male infertility. Asian J Androl. 2014;16:694-7 pubmed publisher
    Monocarboxylic acid transporter 2 (MCT2) transports pyruvate and lactate outside and inside of sperms, mainly as energy sources and plays roles in the regulation of spermatogenesis...