SLC15A4

Summary

Gene Symbol: SLC15A4
Description: solute carrier family 15 member 4
Alias: FP12591, PHT1, PTR4, solute carrier family 15 member 4, hPHT1, peptide transporter 4, peptide-histidine transporter 4, peptide/histidine transporter 1, solute carrier family 15 (oligopeptide transporter), member 4
Species: human
Products:     SLC15A4

Top Publications

  1. Phule A, Barbadikar K, Maganti S, Seguttuvel P, Subrahmanyam D, Babu M, et al. RNA-seq reveals the involvement of key genes for aerobic adaptation in rice. Sci Rep. 2019;9:5235 pubmed publisher
    ..MADS4, MADS5, MADS6, MADS7, MADS15 and transporters involved in sugar (SWEET3A) and nutrient uptake (PHT1;6, MDR-like ABC and vacuolar iron transporter homolog 2) were highly and uniquely expressed in the aerobic adapted ..
  2. Kant S, Peng M, Rothstein S. Genetic regulation by NLA and microRNA827 for maintaining nitrate-dependent phosphate homeostasis in arabidopsis. PLoS Genet. 2011;7:e1002021 pubmed publisher
    ..Map-based cloning identified these suppressors as the phosphate (Pi) transport-related genes PHF1 and PHT1.1. In addition, NLA expression is shown to be regulated by the low-Pi induced microRNA miR827...
  3. Jiang L, Liu C, Cao H, Chen Z, Yang J, Cao S, et al. The role of cytokinin in selenium stress response in Arabidopsis. Plant Sci. 2019;281:122-132 pubmed publisher
    ..activation of metabolism detoxification, which had significantly lower transcriptions of high-affinity transporters PHT1;1, PHT1;8, PHT1;9 and the higher transcription of selenocysteine methyltransferase (SMT) respectively...
  4. Dong Z, Li W, Liu J, Li L, Pan S, Liu S, et al. The Rice Phosphate Transporter Protein OsPT8 Regulates Disease Resistance and Plant Growth. Sci Rep. 2019;9:5408 pubmed publisher
    ..In this study, we identified the rice OsPT8 protein, which is a member of the phosphate transporters (PTs) Pht1 family and also plays a role in rice disease resistance...
  5. Griffith A, Zaidi A, Pietro A, Hadiono M, Yang J, Davis R, et al. A requirement for slc15a4 in imiquimod-induced systemic inflammation and psoriasiform inflammation in mice. Sci Rep. 2018;8:14451 pubmed publisher
    ..We targeted pDC function using the slc15a4feeble loss-of-function mouse whose pDC are unresponsive to TLR agonists...
  6. Simm F, Griesbeck A, Choukair D, Weis B, Paramasivam N, Klammt J, et al. Identification of SLC20A1 and SLC15A4 among other genes as potential risk factors for combined pituitary hormone deficiency. Genet Med. 2018;20:728-736 pubmed publisher
    ..5/E14.5 pituitary transcriptome. Targeted sequencing of two candidate genes, SLC20A1 and SLC15A4, of the solute carrier membrane transport protein family in 200 additional patients demonstrated two further ..
  7. Huang Q, Vera Delgado J, Seni Pinoargote O, Llaguno R. Molecular evolution of the Slc15 family and its response to waterborne copper and mercury exposure in tilapia. Aquat Toxicol. 2015;163:140-7 pubmed publisher
    ..The mRNA levels of all the members (except Slc15a4) decreased after fasting while refeeding could restore the expression level...
  8. Chen Q, Dai W, Sun Y, Zhao F, Liu J, Liu H. Methionine Partially Replaced by Methionyl-Methionine Dipeptide Improves Reproductive Performance over Methionine Alone in Methionine-Deficient Mice. Nutrients. 2018;10: pubmed publisher
    ..Besides, in the placenta, the AA transporter mRNA abundances and peptide transporters (PhT1 and PepT1) protein levels were higher in Met-Met treatment group...
  9. Hu Y, Epling D, Shi J, Song F, Tsume Y, Zhu H, et al. Effect of biphenyl hydrolase-like (BPHL) gene disruption on the intestinal stability, permeability and absorption of valacyclovir in wildtype and Bphl knockout mice. Biochem Pharmacol. 2018;156:147-156 pubmed publisher
    ..e., PepT1, PepT2, PhT1, PhT2), enzymatic upregulation of Cyp3a11, Cyp3a16, Abhd14a and Abhd14b was observed in some tissues of Bphl ..

More Information

Publications62

  1. Ayadi A, David P, Arrighi J, Chiarenza S, Thibaud M, Nussaume L, et al. Reducing the genetic redundancy of Arabidopsis PHOSPHATE TRANSPORTER1 transporters to study phosphate uptake and signaling. Plant Physiol. 2015;167:1511-26 pubmed publisher
    ..Pi) from the soil through an active transport process mediated by the nine members of the PHOSPHATE TRANSPORTER1 (PHT1) family. These proteins share a high level of similarity (greater than 61%), with overlapping expression patterns...
  2. Kobayashi T, Shimabukuro Demoto S, Yoshida Sugitani R, Furuyama Tanaka K, Karyu H, Sugiura Y, et al. The histidine transporter SLC15A4 coordinates mTOR-dependent inflammatory responses and pathogenic antibody production. Immunity. 2014;41:375-388 pubmed publisher
    b>SLC15A4 is a lysosome-resident, proton-coupled amino-acid transporter that moves histidine and oligopeptides from inside the lysosome to the cytosol of eukaryotic cells...
  3. Lapis Gaza H, Jost R, Finnegan P. Arabidopsis PHOSPHATE TRANSPORTER1 genes PHT1;8 and PHT1;9 are involved in root-to-shoot translocation of orthophosphate. BMC Plant Biol. 2014;14:334 pubmed publisher
    In plants, the uptake from soil and intercellular transport of inorganic phosphate (Pi) is mediated by the PHT1 family of membrane-spanning proton : Pi symporters...
  4. Arnaud C, Clément M, Thibaud M, Javot H, Chiarenza S, Delannoy E, et al. Identification of phosphatin, a drug alleviating phosphate starvation responses in Arabidopsis. Plant Physiol. 2014;166:1479-91 pubmed publisher
    ..for their ability to inhibit the expression of a Pi starvation marker gene (the high-affinity Pi transporter PHT1;4)...
  5. Khan E, Gupta M. Arsenic-silicon priming of rice (Oryza sativa L.) seeds influence mineral nutrient uptake and biochemical responses through modulation of Lsi-1, Lsi-2, Lsi-6 and nutrient transporter genes. Sci Rep. 2018;8:10301 pubmed publisher
    ..contents also improved with Si, and differentially regulated 12 key genes (NR, NiR, AMT, NR, GS, GOGAT, PT, PHT1, PHT2, APase, KAT1 and HAK10) related with NPK transport and utilization...
  6. Fontenot E, Ditusa S, Kato N, Olivier D, Dale R, Lin W, et al. Increased phosphate transport of Arabidopsis thaliana Pht1;1 by site-directed mutagenesis of tyrosine 312 may be attributed to the disruption of homomeric interactions. Plant Cell Environ. 2015;38:2012-22 pubmed publisher
    Members of the Pht1 family of plant phosphate (Pi) transporters play vital roles in Pi acquisition from soil and in planta Pi translocation to maintain optimal growth and development...
  7. Dosenovic P, Adori M, Adams W, Pedersen G, Soldemo M, Beutler B, et al. Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation. Immunol Cell Biol. 2015;93:136-46 pubmed publisher
    ..Here, we used feeble mice, which are deficient in the peptide/histidine transporter solute carrier family 15 member 4 (Slc15a4), and fail to produce cytokines including interferon alpha (IFN?) in response to TLR9 ..
  8. Soga M, Ohashi A, Taniguchi M, Matsui T, Tsuda T. The di-peptide Trp-His activates AMP-activated protein kinase and enhances glucose uptake independently of insulin in L6 myotubes. FEBS Open Bio. 2014;4:898-904 pubmed publisher
    ..myotubes express only one type of oligopeptide transporter, peptide/histidine transporter 1 (PHT1, also known as SLC15a4), and WH is incorporated into cells and activates AMPKα following PHT1-mediated cell uptake...
  9. Su T, Xu Q, Zhang F, Chen Y, Li L, Wu W, et al. WRKY42 modulates phosphate homeostasis through regulating phosphate translocation and acquisition in Arabidopsis. Plant Physiol. 2015;167:1579-91 pubmed publisher
    ..Under Pi-sufficient condition, WRKY42 positively regulated PHOSPHATE TRANSPORTER1;1 (PHT1;1) expression by binding to the PHT1;1 promoter, and this binding was abolished by low-Pi stress...
  10. Jost R, Pharmawati M, Lapis Gaza H, Rossig C, Berkowitz O, Lambers H, et al. Differentiating phosphate-dependent and phosphate-independent systemic phosphate-starvation response networks in Arabidopsis thaliana through the application of phosphite. J Exp Bot. 2015;66:2501-14 pubmed publisher
    ..were slower than for phosphate, which may be due to discrimination against phosphite by phosphate transporters PHT1;8 and PHT1;9 causing delayed shoot accumulation of phosphite...
  11. Hu Y, Song F, Jiang H, Nunez G, Smith D. SLC15A2 and SLC15A4 Mediate the Transport of Bacterially Derived Di/Tripeptides To Enhance the Nucleotide-Binding Oligomerization Domain-Dependent Immune Response in Mouse Bone Marrow-Derived Macrophages. J Immunol. 2018;201:652-662 pubmed publisher
    ..of specific POT deletion on the production of inflammatory cytokines in wild-type, Pept2 knockout and Pht1 knockout mice...
  12. Pizzio G, Paez Valencia J, Khadilkar A, Regmi K, Patrón Soberano A, Zhang S, et al. Arabidopsis type I proton-pumping pyrophosphatase expresses strongly in phloem, where it is required for pyrophosphate metabolism and photosynthate partitioning. Plant Physiol. 2015;167:1541-53 pubmed publisher
    ..1 [NRT2.1], NRT2.4, and PHOSPHATE TRANSPORTER1.4 [PHT1.4])...
  13. Wang X, Li Y, Feng M, Smith D. Semi-Mechanistic Population Pharmacokinetic Modeling of L-Histidine Disposition and Brain Uptake in Wildtype and Pht1 Null Mice. Pharm Res. 2018;35:19 pubmed publisher
    ..PK) model to quantitate the disposition kinetics of L-histidine, a peptide-histidine transporter 1 (PHT1) substrate, in the plasma, cerebrospinal fluid and brain parenchyma of wildtype (WT) and Pht1 knockout (KO) mice...
  14. Wang L, ZengJ H, Song J, Feng S, Yang Z. miRNA778 and SUVH6 are involved in phosphate homeostasis in Arabidopsis. Plant Sci. 2015;238:273-85 pubmed publisher
    ..Expression of several Pi deficiency-responsive genes such as miR399, Phosphate Transporter (PHT1;4), Low Phosphate-Resistant1 (LPR1) and Production of Anthocyanin Pigment 1 (PAP1) were elevated in the miR778 ..
  15. Pudake R, Mehta C, Mohanta T, Sharma S, Varma A, Sharma A. Expression of four phosphate transporter genes from Finger millet (Eleusine coracana L.) in response to mycorrhizal colonization and Pi stress. 3 Biotech. 2017;7:17 pubmed publisher
    ..phenomenon in Finger Mille plant, we have cloned four Pht genes from Finger millet, which shares the homology with Pht1 protein family of cereals...
  16. Bista D, Heckathorn S, Jayawardena D, Mishra S, Boldt J. Effects of Drought on Nutrient Uptake and the Levels of Nutrient-Uptake Proteins in Roots of Drought-Sensitive and -Tolerant Grasses. Plants (Basel). 2018;7: pubmed publisher
    ..and P-uptake rates, and concentrations of major nutrient-uptake proteins in roots (NRT1 for NO?, AMT1 for NH?, and PHT1 for P). Drought reduced %N and P, indicating that it reduced nutrient acquisition more than growth...
  17. Kariman K, Barker S, Jost R, Finnegan P, Tibbett M. Sensitivity of jarrah (Eucalyptus marginata) to phosphate, phosphite, and arsenate pulses as influenced by fungal symbiotic associations. Mycorrhiza. 2016;26:401-15 pubmed publisher
    ..The transcript profile of five jarrah high-affinity phosphate transporter (PHT1 family) genes in roots was not altered in response to any of the fungal species tested...
  18. Gan H, Jiao Y, Jia J, Wang X, Li H, Shi W, et al. Phosphorus and nitrogen physiology of two contrasting poplar genotypes when exposed to phosphorus and/or nitrogen starvation. Tree Physiol. 2016;36:22-38 pubmed publisher
    ..Thus, in Ps and Pe, the mRNA levels of PHT1;5, PHT1;9, PHT2;1, AMT2;1 and NR increased in the roots, while PHT1;9, PHO1;H1, PHO2, AMT1;1 and NRT2;1 increased ..
  19. Anoman A, Muñoz Bertomeu J, Rosa Téllez S, Flores Tornero M, Serrano R, Bueso E, et al. Plastidial Glycolytic Glyceraldehyde-3-Phosphate Dehydrogenase Is an Important Determinant in the Carbon and Nitrogen Metabolism of Heterotrophic Cells in Arabidopsis. Plant Physiol. 2015;169:1619-37 pubmed publisher
    ..under the control of photosynthetic (Rubisco small subunit RBCS2B [RBCS]) or heterotrophic (phosphate transporter PHT1.2 [PHT]) cell-specific promoters...
  20. Liu F, Xu Y, Jiang H, Jiang C, Du Y, Gong C, et al. Systematic Identification, Evolution and Expression Analysis of the Zea mays PHT1 Gene Family Reveals Several New Members Involved in Root Colonization by Arbuscular Mycorrhizal Fungi. Int J Mol Sci. 2016;17: pubmed publisher
    The Phosphate Transporter1 (PHT1) family of genes plays pivotal roles in the uptake of inorganic phosphate from soils. However, there is no comprehensive report on the PHT1 family in Zea mays based on the whole genome...
  21. Verri T, Barca A, Pisani P, Piccinni B, Storelli C, Romano A. Di- and tripeptide transport in vertebrates: the contribution of teleost fish models. J Comp Physiol B. 2017;187:395-462 pubmed publisher
    ..PEPT2) mainly allows renal tubular reabsorption of di/tripeptides from ultrafiltration, SLC15A3 (PHT2) and SLC15A4 (PHT1) possibly interact with di/tripeptides and histidine in certain immune cells, and SLC15A5 has unknown ..
  22. Ceasar S, Baker A, Muench S, Ignacimuthu S, Baldwin S. The conservation of phosphate-binding residues among PHT1 transporters suggests that distinct transport affinities are unlikely to result from differences in the phosphate-binding site. Biochem Soc Trans. 2016;44:1541-1548 pubmed
    The plant PHosphate Transporter 1 (PHT1) family of membrane proteins belongs to the major facilitator super family and plays a major role in the acquisition of inorganic phosphate (Pi) from the soil and its transport within the plant...
  23. Cardona López X, Cuyas L, Marín E, Rajulu C, Irigoyen M, Gil E, et al. ESCRT-III-Associated Protein ALIX Mediates High-Affinity Phosphate Transporter Trafficking to Maintain Phosphate Homeostasis in Arabidopsis. Plant Cell. 2015;27:2560-81 pubmed publisher
    ..MVB-mediated sorting of high-affinity phosphate transporters (PHT1) to the vacuole limits their plasma membrane levels under phosphate-sufficient conditions, a process that allows ..
  24. Zhang H, Huang L, Hong Y, Song F. BOTRYTIS-INDUCED KINASE1, a plasma membrane-localized receptor-like protein kinase, is a negative regulator of phosphate homeostasis in Arabidopsis thaliana. BMC Plant Biol. 2016;16:152 pubmed publisher
    ..of reactive oxygen species and downregulated expression of Pi starvation-induced genes including PHR1, WRKY75, AT4, PHT1;2 and PHT1;4 were observed in bik1 plants grown under Pi deficient condition...
  25. Bonnot C, Proust H, Pinson B, Colbalchini F, Lesly Veillard A, Breuninger H, et al. Functional PTB phosphate transporters are present in streptophyte algae and early diverging land plants. New Phytol. 2017;214:1158-1171 pubmed publisher
    ..to be the Na+ /Pi symporters catalysing Pi uptake in chlorophytes, whereas PHOSPHATE TRANSPORTER 1 (PHT1) proteins are the H+ /Pi symporters that carry out Pi uptake in angiosperms...
  26. Mandal A, Pal D, Mitra A. Circumvention of P-gp and MRP2 mediated efflux of lopinavir by a histidine based dipeptide prodrug. Int J Pharm. 2016;512:49-60 pubmed publisher
    ..To further delineate prodrug uptake, prodrug interaction with influx transporters (PepT1 and PHT1) was determined...
  27. Kavka M, Polle A. Phosphate uptake kinetics and tissue-specific transporter expression profiles in poplar (Populus?×?canescens) at different phosphorus availabilities. BMC Plant Biol. 2016;16:206 pubmed
    ..It is transported into and allocated inside plants by four families of phosphate transporters (PHT1 to PHT4) with high or low affinity to phosphate...
  28. Wang Y, Hu Y, Li P, Weng Y, Kamada N, Jiang H, et al. Expression and regulation of proton-coupled oligopeptide transporters in colonic tissue and immune cells of mice. Biochem Pharmacol. 2018;148:163-173 pubmed publisher
    ..Using a dextran sodium sulfate (DSS)-induced colitis mouse model, we found that DSS down regulated Pht1 gene expression and up regulated Pht2 gene expression in colonic tissue and immune cells...
  29. Ceasar S, Baker A, Ignacimuthu S. Functional characterization of the PHT1 family transporters of foxtail millet with development of a novel Agrobacterium-mediated transformation procedure. Sci Rep. 2017;7:14064 pubmed publisher
    ..from the environment and distributed within the plant in part through the action of phosphate transporters of the PHT1 family...
  30. Kobayashi T, Tsutsui H, Shimabukuro Demoto S, Yoshida Sugitani R, Karyu H, Furuyama Tanaka K, et al. Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells. Int Immunol. 2017;29:551-566 pubmed publisher
    ..Solute carrier family member 15A4 (SLC15A4) is a lysosome-resident amino-acid/oligopeptide transporter that is preferentially expressed in hematopoietic ..
  31. Grun A, Buchner P, Broadley M, Hawkesford M. Identification and expression profiling of Pht1 phosphate transporters in wheat in controlled environments and in the field. Plant Biol (Stuttg). 2017;: pubmed publisher
    ..Here, we describe the identification of the complete Pi transporter gene family (Pht1) in wheat (Triticum aestivum)...
  32. Zuo X, Sheng Y, Hu S, Gao J, Li Y, Tang H, et al. Variants in TNFSF4, TNFAIP3, TNIP1, BLK, SLC15A4 and UBE2L3 interact to confer risk of systemic lupus erythematosus in Chinese population. Rheumatol Int. 2014;34:459-64 pubmed publisher
    ..several susceptibility genes involved in NF-?B signaling pathway, including TNFSF4, TNFAIP3, TNIP1, BLK, SLC15A4 and UBE2L3...
  33. James J. Clinical perspectives on lupus genetics: advances and opportunities. Rheum Dis Clin North Am. 2014;40:413-32, vii pubmed publisher
    ..Recent advances have also shown several genetic associations with SLE subphenotypes and subcriteria. Many areas for further exploration remain to move lupus genetic studies toward clinically informative end points. ..
  34. Takeuchi F, Ochiai Y, Serizawa M, Yanai K, Kuzuya N, Kajio H, et al. Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q. J Hum Genet. 2008;53:314-24 pubmed publisher
    ..Also, in the SLC15A4 gene on 12q, rs3765108 showed a marginally significant association with an overall estimated odds ratio of 0...
  35. Wang X, Hu Y, Keep R, Toyama Sorimachi N, Smith D. A novel role for PHT1 in the disposition of l-histidine in brain: In vitro slice and in vivo pharmacokinetic studies in wildtype and Pht1 null mice. Biochem Pharmacol. 2017;124:94-102 pubmed publisher
    PHT1 (SLC15A4) is responsible for translocating l-histidine (l-His), di/tripeptides and peptide-like drugs across biological membranes...
  36. Lei K, Lin Y, Ren J, Bai L, Miao Y, An G, et al. Modulation of the Phosphate-Deficient Responses by MicroRNA156 and its Targeted SQUAMOSA PROMOTER BINDING PROTEIN-LIKE 3 in Arabidopsis. Plant Cell Physiol. 2016;57:192-203 pubmed publisher
    ..an electrophoretic mobility shift assay indicated that the SPL3 protein directly bound to GTAC motifs in the PLDZ2, Pht1;5 and miR399f promoters...
  37. Bhardwaj R, Herrera Ruiz D, Eltoukhy N, Saad M, Knipp G. The functional evaluation of human peptide/histidine transporter 1 (hPHT1) in transiently transfected COS-7 cells. Eur J Pharm Sci. 2006;27:533-42 pubmed
    Recently, the expression of the human peptide/histidine transporter (hPHT1, SLC15A4) mRNA was observed in the GI tract and in Caco-2 cells, suggesting that it may participate in the intestinal absorption of peptide-based agents...
  38. Tai W, Chen Z, Cheng K. Expression profile and functional activity of peptide transporters in prostate cancer cells. Mol Pharm. 2013;10:477-87 pubmed publisher
    ..to evaluate the expression profile of peptide transporter 1 (PEPT1), peptide transporter 2 (PEPT2), peptide histidine transporter 1 (PHT1), and peptide histidine transporter 2 (PHT2) in these cells...
  39. Agu R, Cowley E, Shao D, MacDonald C, Kirkpatrick D, Renton K, et al. Proton-coupled oligopeptide transporter (POT) family expression in human nasal epithelium and their drug transport potential. Mol Pharm. 2011;8:664-72 pubmed publisher
    The molecular and functional expression of peptide transporters (PEPT1 and PEPT2, PHT1, PHT2) in human nasal epithelium was investigated...
  40. Zhang M, Chen F, Zhang D, Zhai Z, Hao F. Association Study Between SLC15A4 Polymorphisms and Haplotypes and Systemic Lupus Erythematosus in a Han Chinese Population. Genet Test Mol Biomarkers. 2016;20:451-8 pubmed publisher
    The gene SLC15A4 (solute carrier family 15 [oligopeptide transporter], member 4) has been reported as contributing to the pathogenesis of systemic lupus erythematosus (SLE)...
  41. Valat L, Deglène Benbrahim L, Kendel M, Hussenet R, Le Jeune C, Schellenbaum P, et al. Transcriptional induction of two phosphate transporter 1 genes and enhanced root branching in grape plants inoculated with Funneliformis mosseae. Mycorrhiza. 2018;28:179-185 pubmed publisher
    ..conditions, and analyzed the concomitant expression of putative mycorrhizal-specific phosphate transporter 1 (PHT1) genes...
  42. Wang M, Wilde J, Baldwin I, Groten K. Nicotiana attenuata's capacity to interact with arbuscular mycorrhiza alters its competitive ability and elicits major changes in the leaf transcriptome. J Integr Plant Biol. 2017;: pubmed publisher
    ..The Pht1 family phosphate transporter NaPT5 was not only specifically induced in roots after AMF colonization, but also in ..
  43. Zvobgo G, LwalabaWaLwalaba J, Sagonda T, Mutemachani Mapodzeke J, Muhammad N, Haider Shamsi I, et al. Phosphate alleviates arsenate toxicity by altering expression of phosphate transporters in the tolerant barley genotypes. Ecotoxicol Environ Saf. 2018;147:832-839 pubmed publisher
    ..Moreover, among 6 PHTs examined in this study, the expressions of PHT1.3, PHT1.4 and PHT1...
  44. Han J, Zheng H, Cui Y, Sun L, Ye D, Hu Z, et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet. 2009;41:1234-7 pubmed publisher
    ..We identified nine new susceptibility loci (ETS1, IKZF1, RASGRP3, SLC15A4, TNIP1, 7q11.23, 10q11.22, 11q23.3 and 16p11.2; 1.77 x 10(-25) < or = P(combined) < or = 2...
  45. D Astous Pagé J, Gariepy C, Blouin R, Cliche S, Méthot S, Sullivan B, et al. Identification of single nucleotide polymorphisms in carnosine-related genes and effects of genotypes on pork meat quality attributes. Meat Sci. 2017;134:54-60 pubmed publisher
    ..This study aimed at identifying polymorphisms in carnosine-related genes (CARNS1, SLC6A6, SLC15A3, SLC15A4) that might associate with muscle carnosine content and meat quality traits in pigs (Duroc, Landrace, Yorkshire)...
  46. Offenbacher S, Divaris K, Barros S, Moss K, Marchesan J, Morelli T, et al. Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease. Hum Mol Genet. 2016;25:2113-2129 pubmed
    ..genome-wide significant signals for PCT1 (CLEC19A, TRA, GGTA2P, TM9SF2, IFI16, RBMS3), PCT4 (HPVC1) and PCT5 (SLC15A4, PKP2, SNRPN)...
  47. He C, Liu Y, Cheng Y, Gao J, Pan T, Han J, et al. TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population. Lupus. 2010;19:1181-6 pubmed publisher
    ..Five novel susceptibility genes (TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1) for SLE have been identified in a recent genome-wide association study of a Chinese Han ..
  48. Liu B, Zhao S, Wu X, Wang X, Nan Y, Wang D, et al. Identification and characterization of phosphate transporter genes in potato. J Biotechnol. 2017;264:17-28 pubmed publisher
    ..that the potato genome has 20 StPHT and StPHOs genes which were grouped into 5 phylogenetical clusters including 8 PHT1 homologs,1 PHT2 homolog, 2 PHT3 homologs, 5 PHT4 homologs and 4 PHO homologs. These genes were mapped on ten S...
  49. Botka C, Wittig T, Graul R, Nielsen C, Higaka K, Amidon G, et al. Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics. AAPS PharmSci. 2000;2:E16 pubmed
    ..The contig sequences and analyses revealed the presence of several possible splice variants of hPHT1. A second closely related human EST-contig displayed high identity to a recently cloned mouse cDNA encoding cyclic ..
  50. Daniel H, Kottra G. The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. Pflugers Arch. 2004;447:610-8 pubmed
    ..Recently, two new peptide transporters, PHT1 (SLC15A4) and PHT2 (SLC15A3), were identified in mammals...
  51. Song F, Hu Y, Wang Y, Smith D, Jiang H. Functional characterization of human peptide/histidine transporter 1 in stably transfected MDCK cells. Mol Pharm. 2017;: pubmed publisher
    The proton-coupled oligopeptide transporter PHT1 (SLC15A4), which facilitates cross-membrane transport of histidine and small peptides from inside the endosomes or lysosomes to cytosol, plays an important role in intracellular peptide ..
  52. Kitakaze T, Sakamoto T, Kitano T, Inoue N, Sugihara F, Harada N, et al. The collagen derived dipeptide hydroxyprolyl-glycine promotes C2C12 myoblast differentiation and myotube hypertrophy. Biochem Biophys Res Commun. 2016;478:1292-7 pubmed publisher
    ..The peptide/histidine transporter 1 (PHT1) was highly expressed in both myoblasts and myotubes, and co-administration of histidine inhibited Hyp-Gly-induced ..
  53. Nakamura N, Lill J, Phung Q, Jiang Z, Bakalarski C, De Mazière A, et al. Endosomes are specialized platforms for bacterial sensing and NOD2 signalling. Nature. 2014;509:240-4 pubmed publisher
    ..Here we show that two endo-lysosomal peptide transporters, SLC15A3 and SLC15A4, are preferentially expressed by dendritic cells, especially after TLR stimulation...