SLC15A1

Summary

Gene Symbol: SLC15A1
Description: solute carrier family 15 member 1
Alias: HPECT1, HPEPT1, PEPT1, solute carrier family 15 member 1, Caco-2 oligopeptide transporter, intestinal H+/peptide cotransporter, macrophage oligopeptide transporter PEPT1, oligopeptide transporter, small intestine isoform, peptide transporter 1, solute carrier family 15 (oligopeptide transporter), member 1
Species: human
Products:     SLC15A1

Top Publications

  1. Herrera Ruiz D, Faria T, Bhardwaj R, Timoszyk J, Gudmundsson O, Moench P, et al. A novel hPepT1 stably transfected cell line: establishing a correlation between expression and function. Mol Pharm. 2004;1:136-44 pubmed
    Stably transfected MDCK/hPepT1-V5&His clonal cell lines expressing varying levels of epitope-tagged hPepT1 protein were established to quantify the relationship between transgene hPepT1 expression levels and its functional kinetics in ..
  2. Zucchelli M, Torkvist L, Bresso F, Halfvarson J, Hellquist A, Anedda F, et al. PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease. Inflamm Bowel Dis. 2009;15:1562-9 pubmed publisher
    ..The intestinal transporter PepT1, encoded by the SLC15A1 gene, mediates intracellular uptake of bacterial products that can induce inflammation and NF-kappaB activation ..
  3. Nguyen H, Dalmasso G, Powell K, Yan Y, Bhatt S, Kalman D, et al. Pathogenic bacteria induce colonic PepT1 expression: an implication in host defense response. Gastroenterology. 2009;137:1435-47.e1-2 pubmed publisher
    Expression of the di/tripeptide transporter PepT1 has been observed in the colon under inflammatory conditions; however, the inducing factors and underlying mechanisms remain unknown...
  4. Dalmasso G, Nguyen H, Ingersoll S, Ayyadurai S, Laroui H, Charania M, et al. The PepT1-NOD2 signaling pathway aggravates induced colitis in mice. Gastroenterology. 2011;141:1334-45 pubmed publisher
    The human di/tripeptide transporter human intestinal H-coupled oligonucleotide transporter (hPepT1) is abnormally expressed in colons of patients with inflammatory bowel disease, although its exact role in pathogenesis is unclear...
  5. Ganapathy M, Brandsch M, Prasad P, Ganapathy V, Leibach F. Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. J Biol Chem. 1995;270:25672-7 pubmed
    ..It is concluded that there are marked differences between the intestinal and renal peptide transporters in the recognition of beta -lactam antibiotics as substrates. ..
  6. Dalmasso G, Nguyen H, Charrier Hisamuddin L, Yan Y, Laroui H, Demoulin B, et al. PepT1 mediates transport of the proinflammatory bacterial tripeptide L-Ala-{gamma}-D-Glu-meso-DAP in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2010;299:G687-96 pubmed publisher
    b>PepT1 is a di/tripeptide transporter highly expressed in the small intestine, but poorly or not expressed in the colon. However, during chronic inflammation, such as inflammatory bowel disease, PepT1 expression is induced in the colon...
  7. Al Wakeel R, Shukry M, Abdel Azeez A, Mahmoud S, Saad M. Alleviation by gamma amino butyric acid supplementation of chronic heat stress-induced degenerative changes in jejunum in commercial broiler chickens. Stress. 2017;20:562-572 pubmed publisher
    ..supplementation significantly modulated HS-induced changes in glucose facilitated transporter 2 (GLUT2), peptide transporter 1 (PEPT1) and heat shock protein 70 (HSP70) mRNA expression in the jejunal mucosa (p?<?.0001)...
  8. Cheng X, Gu J, Klaassen C. Adaptive hepatic and intestinal alterations in mice after deletion of NADPH-cytochrome P450 Oxidoreductase (Cpr) in hepatocytes. Drug Metab Dispos. 2014;42:1826-33 pubmed publisher
    ..In addition, nutrient (Pept1) and cholesterol (Npc1l1) transporters are induced in the small intestine of H-Cpr-null mice...
  9. Kabeya T, Qiu S, Hibino M, Nagasaki M, Kodama N, Iwao T, et al. Cyclic AMP Signaling Promotes the Differentiation of Human Induced Pluripotent Stem Cells into Intestinal Epithelial Cells. Drug Metab Dispos. 2018;46:1411-1419 pubmed publisher
    ..Furthermore, uptake of glycylsarcosine via peptide transporter 1 was markedly increased...

More Information

Publications133 found, 100 shown here

  1. Sopjani M, Thaçi S, Krasniqi B, Selmonaj M, Rinnerthaler M, Dërmaku Sopjani M. Regulation of Ion Channels, Cellular Carriers and Na(+)/K(+)/ATPase by Janus Kinase 3. Curr Med Chem. 2017;24:2251-2260 pubmed publisher
    ..transporter SGLT1, the excitatory amino acid transporters EAAT1, EAAT2, EAAT3 and EAAT4, the peptide transporters PepT1 and PepT2, CreaT1 and theNa+/K+-ATPase...
  2. Sopjani M, Konjufca V, Rinnerthaler M, Rexhepaj R, Dërmaku Sopjani M. The Relevance of JAK2 in the Regulation of Cellular Transport. Curr Med Chem. 2016;23:578-88 pubmed
    ..and chloride ion channels, multiple Na+-coupled cellular carriers including EAAT1-4, NaPi-IIa, SGLT1, BoaT1, PepT1-2, CreaT1, SMIT1, and BGT1 as well as Na(+)/K(+)-ATPase...
  3. Everaert I, Baron G, Barbaresi S, Gilardoni E, Coppa C, Carini M, et al. Development and validation of a sensitive LC-MS/MS assay for the quantification of anserine in human plasma and urine and its application to pharmacokinetic study. Amino Acids. 2019;51:103-114 pubmed publisher
    ..Conversely, the two dipeptides seems to have similar interaction with the PEPT1 transporter...
  4. Sowmya K, Mala D, Bhat M, Kumar N, Bajaj R, Kapila S, et al. Bio-accessible milk casein derived tripeptide (LLY) mediates overlapping anti- inflammatory and anti-oxidative effects under cellular (Caco-2) and in vivo milieu. J Nutr Biochem. 2018;62:167-180 pubmed publisher
    ..72±0.22% through PepT1 mediated transport mechanism...
  5. Fu Z, Selwyn F, Cui J, Klaassen C. RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice. Drug Metab Dispos. 2017;45:1225-1238 pubmed publisher
    ..apical sodium-dependent bile acid transporter, organic solute transporter α and β), peptide transporter 1, and multidrug and toxin extrusion protein 1, exhibited higher expression in GF mice...
  6. Vuille dit Bille R, Camargo S, Emmenegger L, Sasse T, Kummer E, Jando J, et al. Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors. Amino Acids. 2015;47:693-705 pubmed publisher
    ..in comparison with untreated controls increased intestinal mRNA levels of ACE2, peptide transporter PEPT1 (SLC15A1) and AA transporters B(0)AT1 and PAT1 (SLC36A1)...
  7. Borey M, Panserat S, Surget A, Cluzeaud M, Plagnes Juan E, Herman A, et al. Postprandial kinetics of gene expression of proteins involved in the digestive process in rainbow trout (O. mykiss) and impact of diet composition. Fish Physiol Biochem. 2016;42:1187-202 pubmed publisher
    ..levels of dietary incorporation induced a significant decrease in the gene expression of gastric lipase, GLUT2 and PEPT1. The plasma glucose and triglycerides levels were also reduced in trout fed the noFM-noFO diet...
  8. Qiu K, Qin C, Luo M, Zhang X, Sun W, Jiao N, et al. Protein Restriction with Amino Acid-Balanced Diets Shrinks Circulating Pool Size of Amino Acid by Decreasing Expression of Specific Transporters in the Small Intestine. PLoS ONE. 2016;11:e0162475 pubmed publisher
    ..Meanwhile, the expression of peptide transporter 1 (PepT-1) was stimulated, but the expression of the neutral and cationic AA transporter systems was ..
  9. Iwao T, Kodama N, Kondo Y, Kabeya T, Nakamura K, Horikawa T, et al. Generation of enterocyte-like cells with pharmacokinetic functions from human induced pluripotent stem cells using small-molecule compounds. Drug Metab Dispos. 2015;43:603-10 pubmed publisher
    ..and was inhibited by ibuprofen, an inhibitor of the intestinal oligopeptide transporter solute carrier 15A1/PEPT1. CYP3A4 mRNA expression level was increased by these compounds and induced by the addition of 1α,25-..
  10. Kodama N, Iwao T, Katano T, Ohta K, Yuasa H, Matsunaga T. Characteristic Analysis of Intestinal Transport in Enterocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells. Drug Metab Dispos. 2016;44: pubmed publisher
    ..The uptake of peptide transporter 1 substrate glycylsarcosine was also confirmed and suppressed when the temperature was lowered to 4°C...
  11. Ekmay R, Chou K, Magnuson A, Lei X. Continual feeding of two types of microalgal biomass affected protein digestion and metabolism in laying hens. J Anim Sci. 2015;93:287-97 pubmed publisher
    ..exhibited moderate effects on intestinal brush border protease activities and mRNA levels of duodenal transporters Pept1, Lat1, and Cat1, both substantially enhanced (P < 0...
  12. Holland A, Hyatt H, Smuder A, Sollanek K, Morton A, Roberts M, et al. Influence of endurance exercise training on antioxidant enzymes, tight junction proteins, and inflammatory markers in the rat ileum. BMC Res Notes. 2015;8:514 pubmed publisher
    ..ileum mRNA expressions of seven nutrient transporters (SLC5A8, SLC7A6, SLC6A19, SLC7A7, SLC27A2, SLC16A10, and SLC15A1) were not different between the two groups (p > 0.05). EXE had lower ileum TNFα mRNA expression (p < 0...
  13. Hu Y, Epling D, Shi J, Song F, Tsume Y, Zhu H, et al. Effect of biphenyl hydrolase-like (BPHL) gene disruption on the intestinal stability, permeability and absorption of valacyclovir in wildtype and Bphl knockout mice. Biochem Pharmacol. 2018;156:147-156 pubmed publisher
    ..e., PepT1, PepT2, PhT1, PhT2), enzymatic upregulation of Cyp3a11, Cyp3a16, Abhd14a and Abhd14b was observed in some tissues ..
  14. Richards P, Pais R, Habib A, Brighton C, Yeo G, Reimann F, et al. High fat diet impairs the function of glucagon-like peptide-1 producing L-cells. Peptides. 2016;77:21-7 pubmed publisher
    ..Sct, Nts), prohormone processing enzymes (Pcsk1, Cpe), granins (Chgb, Scg2), nutrient sensing machinery (Slc5a1, Slc15a1, Abcc8, Gpr120) and enteroendocrine-specific transcription factors (Etv1, Isl1, Mlxipl, Nkx2.2 and Rfx6)...
  15. Tao W, Zhao D, Sun M, Li M, Zhang X, He Z, et al. Enzymatic activation of double-targeted 5'-O-L-valyl-decitabine prodrug by biphenyl hydrolase-like protein and its molecular design basis. Drug Deliv Transl Res. 2017;7:304-311 pubmed publisher
    ..was synthesized before and can be transported across biological membranes by the oligopeptide transporter (PEPT1), granting it much greater utility in vivo...
  16. de la Ballina L, Cano Crespo S, González Muñoz E, Bial S, Estrach S, Cailleteau L, et al. Amino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) Is at the Cross-road of Oxidative Stress and Amino Acid Availability. J Biol Chem. 2016;291:9700-11 pubmed publisher
    ..of branched-chain and aromatic amino acids (BCAAs and ARO AAs, respectively) and induced expression of peptide transporter 1 (PEPT1)...
  17. de Almeida Chuffa L, Seiva F, Cucielo M, Silveira H, Reiter R, Lupi L. Mitochondrial functions and melatonin: a tour of the reproductive cancers. Cell Mol Life Sci. 2019;76:837-863 pubmed publisher
    ..Melatonin is transported into tumor cell by GLUT/SLC2A and/or by the PEPT1/2 transporters, and plays beneficial roles in mitochondrial homeostasis, such as influencing oxidative ..
  18. Huang W, Chang J, Wang P, Liu C, Yin Q, Song A, et al. Effect of Compound Probiotics and Mycotoxin Degradation Enzymes on Alleviating Cytotoxicity of Swine Jejunal Epithelial Cells Induced by Aflatoxin B₁ and Zearalenone. Toxins (Basel). 2019;11: pubmed publisher
    ..genes were significantly upregulated, while Bax, caspase-3, GLUT2, ASCT2, PepT1, and IL6 genes were significantly downregulated by CFSCP + MDE addition, compared to the groups ..
  19. Fujishiro T, Nonoguchi N, Pavliukov M, Ohmura N, Kawabata S, Park Y, et al. 5-Aminolevulinic acid-mediated photodynamic therapy can target human glioma stem-like cells refractory to antineoplastic agents. Photodiagnosis Photodyn Ther. 2018;24:58-68 pubmed publisher
    ..GSLCs expressed higher mRNA levels of PpIX biosynthesis enzymes and its transporters PEPT1/2 and ABCB6, when compared to the parental A172 glioma cells...
  20. Sampaio I, Medeiros P, Rodrigues F, Cavalcante P, Ribeiro S, Oliveira J, et al. Impact of acute undernutrition on growth, ileal morphology and nutrient transport in a murine model. Braz J Med Biol Res. 2016;49:e5340 pubmed publisher
    ..Transcription of Sglt1 and Pept1 was significantly higher in the undernourished group, while SN-2 transcription was decreased...
  21. Klinger S, Breves G. Resveratrol Inhibits Porcine Intestinal Glucose and Alanine Transport: Potential Roles of Na?/K?-ATPase Activity, Protein Kinase A, AMP-Activated Protein Kinase and the Association of Selected Nutrient Transport Proteins with Detergent Resistant Memb. Nutrients. 2018;10: pubmed publisher
    ..The DRM association of SGLT1, peptide transporter 1 (PEPT1) and (phosphorylated) Na?/H?-exchanger 3 (NHE3) did not change...
  22. Hu Y, Song F, Jiang H, Nunez G, Smith D. SLC15A2 and SLC15A4 Mediate the Transport of Bacterially Derived Di/Tripeptides To Enhance the Nucleotide-Binding Oligomerization Domain-Dependent Immune Response in Mouse Bone Marrow-Derived Macrophages. J Immunol. 2018;201:652-662 pubmed publisher
    ..We found that PEPT2 and PHT1 were highly expressed and functionally active in mouse macrophages, but PEPT1 was absent...
  23. Liu C, Niu Y, Zhou X, Xu X, Yang Y, Zhang Y, et al. Cell cycle control, DNA damage repair, and apoptosis-related pathways control pre-ameloblasts differentiation during tooth development. BMC Genomics. 2015;16:592 pubmed publisher
    ..to differentiation, containing transcription regulators (RUNX2, ETV1 and ETV5), solute carrier family members (SLC15A1 and SLC7A11), enamel matrix protein (MMP20), and a polymodal excitatory ion channel (TRPA1)...
  24. Habashy W, Milfort M, Fuller A, Attia Y, Rekaya R, Aggrey S. Effect of heat stress on protein utilization and nutrient transporters in meat-type chickens. Int J Biometeorol. 2017;61:2111-2118 pubmed publisher
    ..Meanwhile, FABP1 and PepT1 were down-regulated only in the ileum of the HS group. The converse was shown in P. major...
  25. Chen Q, Dai W, Sun Y, Zhao F, Liu J, Liu H. Methionine Partially Replaced by Methionyl-Methionine Dipeptide Improves Reproductive Performance over Methionine Alone in Methionine-Deficient Mice. Nutrients. 2018;10: pubmed publisher
    ..Besides, in the placenta, the AA transporter mRNA abundances and peptide transporters (PhT1 and PepT1) protein levels were higher in Met-Met treatment group...
  26. Murakami T. A Minireview: Usefulness of Transporter-Targeted Prodrugs in Enhancing Membrane Permeability. J Pharm Sci. 2016;105:2515-2526 pubmed publisher
    ..are amino acid transporter 1, bile acid transporter, carnitine transporter 2, glucose transporter 1, peptide transporter 1, vitamin C transporter 1, and multivitamin transporter...
  27. Reiter R, Rosales Corral S, Tan D, Jou M, Galano A, Xu B. Melatonin as a mitochondria-targeted antioxidant: one of evolution's best ideas. Cell Mol Life Sci. 2017;74:3863-3881 pubmed publisher
    ..Melatonin presumably enters mitochondria through oligopeptide transporters, PEPT1, and PEPT2...
  28. Cao M, Che L, Wang J, Yang M, Su G, Fang Z, et al. Effects of maternal over- and undernutrition on intestinal morphology, enzyme activity, and gene expression of nutrient transporters in newborn and weaned pigs. Nutrition. 2014;30:1442-7 pubmed publisher
    ..05) at birth. Expression of mRNA for SGLT1, GLUT2, PEPT1, and GLP2R were significantly increased (+1.7∼9.6-fold; P < 0...
  29. Azzolini M, Mattarei A, La Spina M, Fanin M, Chiodarelli G, Romio M, et al. New natural amino acid-bearing prodrugs boost pterostilbene's oral pharmacokinetic and distribution profile. Eur J Pharm Biopharm. 2017;115:149-158 pubmed publisher
    ..could have promising absorption profiles also in humans; its uptake is partly due to passive diffusion, and partly mediated by H+-dependent transporters expressed on the apical membrane of enterocytes, such as PepT1 and OATP.
  30. Gilchrist S, Alcorn J. Lactation stage-dependent expression of transporters in rat whole mammary gland and primary mammary epithelial organoids. Fundam Clin Pharmacol. 2010;24:205-14 pubmed publisher
    ..in early lactation, which may remain elevated or decline with advancing lactation (Octn1, Cnt2, Cnt3, Ent1, Pept1, Pept2); (iii) constant but decreasing later in lactation (Octn3, Dmt1); (iv) increasing until mid-to-late ..
  31. Mayo J, Sainz R, González Menéndez P, Hevia D, Cernuda Cernuda R. Melatonin transport into mitochondria. Cell Mol Life Sci. 2017;74:3927-3940 pubmed publisher
    ..uptake involving the facilitative glucose transporters GLUT/SLC2A and the proton-driven oligopeptide transporter PEPT1/2 have been reported...
  32. Reyer H, Zentek J, Männer K, Youssef I, Aumiller T, Weghuber J, et al. Possible Molecular Mechanisms by Which an Essential Oil Blend from Star Anise, Rosemary, Thyme, and Oregano and Saponins Increase the Performance and Ileal Protein Digestibility of Growing Broilers. J Agric Food Chem. 2017;65:6821-6830 pubmed publisher
    ..analyses in Caco-2 showed a significant increase in transporter recruitment to the membrane (SGLT1 and PEPT1) after addition of essential oils and saponins...
  33. Serrado Marques J, Teixeira V, Jacinto A, Tavares A. Identification of Novel Hemangioblast Genes in the Early Chick Embryo. Cells. 2018;7: pubmed publisher
    ..These include the solute carrier transporters SLC15A1 and SCL32A1, the cytoskeletal protein RhoGap6, the serine protease CTSG, the ..
  34. Yin H, Sumners L, Dalloul R, Miska K, Fetterer R, Jenkins M, et al. Changes in expression of an antimicrobial peptide, digestive enzymes, and nutrient transporters in the intestine of E. praecox-infected chickens. Poult Sci. 2015;94:1521-6 pubmed publisher
    ..LEAP2), the cationic (CAT1), anionic (EAAT3), and L-type (LAT1) amino acid transporters, the peptide transporter PepT1 and the zinc transporter ZnT1. Other transporters were downregulated either at d3 or d6...
  35. Chen M, Li X, Yan H, Wang X, Gao C. Effect of egg weight on composition, embryonic growth, and expression of amino acid transporter genes in yolk sac membranes and small intestines of the domestic pigeon (Columba livia). Poult Sci. 2016;95:1425-32 pubmed publisher
    ..05). Furthermore, the abundance of CAT2 and PepT1 mRNA in the yolk sac membranes was greater in the HE than in the LE on E13 (P < 0.05)...
  36. Boggavarapu R, Jeckelmann J, Harder D, Ucurum Z, Fotiadis D. Role of electrostatic interactions for ligand recognition and specificity of peptide transporters. BMC Biol. 2015;13:58 pubmed publisher
    ..from the prokaryotic peptide transporter YePEPT combined with mutagenesis and functional uptake studies with human PEPT1 expressed in Xenopus oocytes also allowed tuning of human PEPT1's substrate specificity, thus improving our ..
  37. Stelzl T, Geillinger Kästle K, Stolz J, Daniel H. Glycans in the intestinal peptide transporter PEPT1 contribute to function and protect from proteolysis. Am J Physiol Gastrointest Liver Physiol. 2017;312:G580-G591 pubmed publisher
    ..We recently demonstrated that the proton-coupled oligopeptide transporter 1 (PEPT1) in the intestine is glycosylated at six asparagine residues (N50, N406, N439, N510, N515, and N532)...
  38. Pieri M, Christian H, Wilkins R, Boyd C, Meredith D. The apical (hPepT1) and basolateral peptide transport systems of Caco-2 cells are regulated by AMP-activated protein kinase. Am J Physiol Gastrointest Liver Physiol. 2010;299:G136-43 pubmed publisher
    ..and transepithelial fluxes of [(3)H]-D-Phe-L-Gln were carried out in differentiated Caco-2 cell monolayers, and hPepT1 and glucose transporter 2 (GLUT2) protein levels were quantified by immunogold electron microscopy...
  39. da Rocha Filho H, da Silva E, Silva F, Courrol L, de Mesquita C, Bellini M. Expression of Genes Involved in Porphyrin Biosynthesis Pathway in the Human Renal Cell Carcinoma. J Fluoresc. 2015;25:1363-9 pubmed publisher
    ..In conclusion, our results demonstrate the preferential accumulation of ALA-induced PpIX in human RCC and also indicate that PEPT1, FECH and HO-1 genes are major contributors to this accumulation.
  40. Zhou Y, Hao G, Zhong H, Wu Q, Lu S, Zhao Q, et al. Human chorionic gonadotropin promotes expression of protein absorption factors in the intestine of goldfish (Carassius auratus). Genet Mol Res. 2015;14:8306-13 pubmed publisher
    ..The expression of CDX2, CREB, gluatamate dehydrogenase, LAT2, aminopeptidase N, PepT1, and SP1 were significantly elevated from the non-breeding season to the breeding season in female goldfish, and ..
  41. Jin G, Li Y, Zhu Y, Du L, Yan J, Yang Q. SMS regulates the expression and function of P-gp and MRP2 in Caco-2 cells. Cell Biol Toxicol. 2016;32:483-497 pubmed
    ..of P-glycoprotein (P-gp) and multidrug resistance protein 2 (MRP2) rather than other drug transporters MRP1, MRP3, PEPT1, OATP2B1, and BCRP...
  42. Kobayashi T, Koizumi T, Kobayashi M, Ogura J, Horiuchi Y, Kimura Y, et al. Insulin stimulates transport of organic anion compounds mediated by organic anion transporting polypeptide 2B1 in the human intestinal cell line Caco-2. Drug Metab Pharmacokinet. 2017;32:157-163 pubmed publisher
    ..It has been reported that insulin stimulates peptide transporter 1 (PEPT1) expression at the apical membrane and increases uptake of PEPT1 substrates in small intestine ..
  43. Adibi S. The oligopeptide transporter (Pept-1) in human intestine: biology and function. Gastroenterology. 1997;113:332-40 pubmed
  44. Liu H, Wang J, Mou D, Che L, Fang Z, Feng B, et al. Maternal Methyl Donor Supplementation during Gestation Counteracts the Bisphenol A-Induced Impairment of Intestinal Morphology, Disaccharidase Activity, and Nutrient Transporters Gene Expression in Newborn and Weaning Pigs. Nutrients. 2017;9: pubmed publisher
    ..to crypt depth, decreased the jejunum sucrase activity, down-regulated the mRNA expression of jejunum peptide transporter 1 (Pept1) and DNA methyl transferase 3a (DNMT3a), and decreased the DNA methylation level of ..
  45. Beale J, Parker J, Samsudin F, Barrett A, Senan A, Bird L, et al. Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport. Structure. 2015;23:1889-1899 pubmed publisher
    Mammals obtain nitrogen via the uptake of di- and tri-peptides in the gastrointestinal tract through the action of PepT1 and PepT2, which are members of the POT family of proton-coupled oligopeptide transporters...
  46. Wang B, Li B. Effect of molecular weight on the transepithelial transport and peptidase degradation of casein-derived peptides by using Caco-2 cell model. Food Chem. 2017;218:1-8 pubmed publisher
    ..The maximum hydrolysis rate of the former was 6.91 and 5.59?M Gly/min for the latter. However, PepT1 was involved in the transport of F3 (<500Da) and its bioavailability was 16.23%...
  47. Alghamdi O, King N, Jones G, Moens P. Kinetic Measurements of Di- and Tripeptide and Peptidomimetic Drug Transport in Different Kidney Regions Using the Fluorescent Membrane Potential-Sensitive Dye, DiS-C3-(3). J Membr Biol. 2017;250:641-649 pubmed publisher
    Tri- and dipeptides are transported in the kidney by PEPT1 and PEPT2 isoforms...
  48. Hindlet P, Bado A, Kamenicky P, Delomenie C, Bourasset F, Nazaret C, et al. Reduced intestinal absorption of dipeptides via PepT1 in mice with diet-induced obesity is associated with leptin receptor down-regulation. J Biol Chem. 2009;284:6801-8 pubmed publisher
    ..reported that acute leptin treatment enhances the absorption of di- and tripeptides via the proton-dependent PepT1 transporter...
  49. Wang H, Shi F, Hou M, Fu X, Long R. Cloning of oligopeptide transport carrier PepT1 and comparative analysis of PepT1 messenger ribonucleic acid expression in response to dietary nitrogen levels in yak () and indigenous cattle () on the Qinghai-Tibetan plateau. J Anim Sci. 2016;94:3431-3340 pubmed
    ..The yak PepT1 (yPepT1) cDNA was cloned in omasum epithelial tissue...
  50. Wang B, Li B. Charge and hydrophobicity of casein peptides influence transepithelial transport and bioavailability. Food Chem. 2018;245:646-652 pubmed publisher
    ..charged peptide fractions (CF1, CF2 and CF3) and the more hydrophilic fraction (HF1) were mainly transported via PepT1 and paracellular routes...
  51. Doring F, Martini C, Walter J, Daniel H. Importance of a small N-terminal region in mammalian peptide transporters for substrate affinity and function. J Membr Biol. 2002;186:55-62 pubmed
    The two closely related, proton-coupled, electrogenic mammalian peptide transporters PEPT1 and PEPT2 differ substantially in substrate affinity and mode of function...
  52. Vavricka S, Musch M, Chang J, Nakagawa Y, Phanvijhitsiri K, Waypa T, et al. hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells. Gastroenterology. 2004;127:1401-9 pubmed
    ..We hypothesized that the intestinal apical di-/tripeptide transporter, hPepT1, transports MDP, thereby activating downstream pathways similar to nuclear factor kappa B (NF-kappaB)...
  53. Kulkarni A, Davies D, Links J, Patel L, Lee V, Haworth I. A charge pair interaction between Arg282 in transmembrane segment 7 and Asp341 in transmembrane segment 8 of hPepT1. Pharm Res. 2007;24:66-72 pubmed
    To determine whether R282 in transmembrane segment 7 (TMS7) of hPepT1 forms a salt bridge with D341 in TMS8. Mutated hPepT1 transporters containing point mutations at R282 and/or D341 were transiently transfected into HEK293 cells...
  54. Nakai Y, Tatsumi Y, Miyake M, Anai S, Kuwada M, Onishi S, et al. Expression of ferrochelatase has a strong correlation in protoporphyrin IX accumulation with photodynamic detection of bladder cancer. Photodiagnosis Photodyn Ther. 2016;13:225-232 pubmed publisher
    ..Western blotting was used to determine the expression of peptide transporter 1, hydroxymethylbilane synthase, ferrochelatase, ATP-binding cassette 2, and heme oxygenase-1 in bladder ..
  55. Verri T, Barca A, Pisani P, Piccinni B, Storelli C, Romano A. Di- and tripeptide transport in vertebrates: the contribution of teleost fish models. J Comp Physiol B. 2017;187:395-462 pubmed publisher
    ..Of its members, SLC15A1 (PEPT1) chiefly mediates intestinal absorption of luminal di/tripeptides from dietary protein digestion, while ..
  56. Sala Rabanal M, Loo D, Hirayama B, Turk E, Wright E. Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1. J Physiol. 2006;574:149-66 pubmed
    The human intestinal proton-coupled oligopeptide transporter hPEPT1 has been implicated in the absorption of pharmacologically active compounds...
  57. Nakanishi T, Tamai I. Interaction of Drug or Food with Drug Transporters in Intestine and Liver. Curr Drug Metab. 2015;16:753-64 pubmed
    ..Among those transporters, this review will focus on PEPT1 and OATP2B1 as influx transporter and p-glycoprotein (P-gp) and BCRP as efflux transporter in intestinal ..
  58. Auda S, Knutter I, Bretschneider B, Brandsch M, Mrestani Y, Große C, et al. Effect of Different Metal Ions on the Biological Properties of Cefadroxil. Pharmaceuticals (Basel). 2009;2:184-193 pubmed
    ..2.0]oct-2-ene-2-carboxylic acid] was investigated. The [14C]Gly-Sar uptake via PEPT1 was inhibited by Zn2+ and Cu2+ treatment in a concentration-dependent manner (Ki ..
  59. Bartoszewski R, Brewer J, Rab A, Crossman D, Bartoszewska S, Kapoor N, et al. The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes. J Biol Chem. 2011;286:41862-70 pubmed publisher
    ..major histocompatibility complex (MHC) class I gene products, interferon-induced genes, and the ER antigen peptide transporter 1 (TAP1)...
  60. Xie Y, Hu Y, Smith D. The proton-coupled oligopeptide transporter 1 plays a major role in the intestinal permeability and absorption of 5-aminolevulinic acid. Br J Pharmacol. 2016;173:167-76 pubmed publisher
    ..of 5-ALA were evaluated to probe the contribution of the proton-coupled oligopeptide transporter 1 (PEPT1) to the oral absorption and systemic exposure of this substrate...
  61. Samsudin F, Parker J, Sansom M, Newstead S, Fowler P. Accurate Prediction of Ligand Affinities for a Proton-Dependent Oligopeptide Transporter. Cell Chem Biol. 2016;23:299-309 pubmed publisher
    ..One example is the proton-dependent oligopeptide transporter PepT1, also known as SLC15A1, which is responsible for the uptake of the ?-lactam antibiotics and various peptide-based prodrugs...
  62. Zhan K, Jiang M, Sui Y, Yan K, Lin M, Zhao G. Establishment of immortalized mouse intestinal epithelial cells line and study of effects of Arg-Arg on inflammatory response. In Vitro Cell Dev Biol Anim. 2017;53:538-546 pubmed publisher
    ..immortalized MIEs showed positive reaction against cytokeratine 18 antigen, E-cadherin, and peptide transporters (Pept1) using indirect immunofluorescence...
  63. Dranse H, Waise T, Hamr S, Bauer P, Abraham M, Rasmussen B, et al. Physiological and therapeutic regulation of glucose homeostasis by upper small intestinal PepT1-mediated protein sensing. Nat Commun. 2018;9:1118 pubmed publisher
    ..Inhibition of upper small intestinal peptide transporter 1 (PepT1), the primary oligopeptide transporter in the small intestine, reverses the preabsorptive ability ..
  64. Koven W, Schulte P. The effect of fasting and refeeding on mRNA expression of PepT1 and gastrointestinal hormones regulating digestion and food intake in zebrafish (Danio rerio). Fish Physiol Biochem. 2012;38:1565-1575 pubmed publisher
    ..is absorbed as di- and tripeptides through a brush border membrane proton/oligopeptide transporter protein called PepT1. The aim of the present study was to determine the effect of short-term food deprivation and refeeding in adult ..
  65. Warsi J, Hosseinzadeh Z, Elvira B, Pelzl L, Shumilina E, Zhang D, et al. USP18 Sensitivity of Peptide Transporters PEPT1 and PEPT2. PLoS ONE. 2015;10:e0129365 pubmed publisher
    ..The present study thus explored, whether USP18 modifies the activity of the peptide transporters PEPT1 and PEPT2, and whether the peptide transporters are sensitive to the ubiquitin ligase Nedd4-2...
  66. Stelzl T, Baranov T, Geillinger K, Kottra G, Daniel H. Effect of N-glycosylation on the transport activity of the peptide transporter PEPT1. Am J Physiol Gastrointest Liver Physiol. 2016;310:G128-41 pubmed publisher
    The intestinal peptide transporter PEPT1 provides bulk quantities of amino acids to epithelial cells...
  67. Nosworthy M, Dodge M, Bertolo R, Brunton J. Enterally delivered dipeptides improve small intestinal inflammatory status in a piglet model of intestinal resection. Clin Nutr. 2016;35:852-8 pubmed publisher
    b>PepT1, a di/tripeptide transporter, is preferentially preserved over free amino acid transporters in situations of gut stress...
  68. Yu Q, Liu X, Liu Y, Riederer B, Li T, Tian D, et al. Defective small intestinal anion secretion, dipeptide absorption, and intestinal failure in suckling NBCe1-deficient mice. Pflugers Arch. 2016;468:1419-32 pubmed publisher
    ..that load the surface enterocytes with acid, such as Slc26a3 (DRA)-mediated luminal Cl(-)/HCO3 (-) exchange or PEPT1-mediated H(+)/dipeptide uptake...
  69. Colas C, Masuda M, Sugio K, Miyauchi S, Hu Y, Smith D, et al. Chemical Modulation of the Human Oligopeptide Transporter 1, hPepT1. Mol Pharm. 2017;: pubmed publisher
    ..dietary proteins and peptide-like drugs are transported via the proton-dependent oligopeptide transporter hPepT1 (SLC15A1)...
  70. Gukasyan H, Uchiyama T, Kim K, Ehrhardt C, Wu S, Borok Z, et al. Oligopeptide Transport in Rat Lung Alveolar Epithelial Cells is Mediated by Pept2. Pharm Res. 2017;34:2488-2497 pubmed publisher
    ..Messenger RNA and protein expression of Pept1 and Pept2 in alveolar epithelial type I- and type II-like cell monolayers (±KGF, resp...
  71. Zhang H, Wong E. Identification of cells expressing OLFM4 and LGR5 mRNA by in situ hybridization in the yolk sac and small intestine of embryonic and early post-hatch chicks. Poult Sci. 2017;: pubmed publisher
    ..Dual label staining at doh for the peptide transporter PepT1 and Olfm4 revealed a population of cells above the crypts that did not express Olfm4 or PepT1 mRNA...
  72. Foster D, Yee S, Bleske B, Carver P, Shea M, Menon S, et al. Lack of interaction between the peptidomimetic substrates captopril and cephradine. J Clin Pharmacol. 2009;49:360-7 pubmed publisher
    Intestinal peptide transporters, including hPEPT1, facilitate the absorption of cephalosporins and angiotensin-converting enzyme inhibitors, and have been investigated as a means to improve oral drug absorption...
  73. Spanier B. Transcriptional and functional regulation of the intestinal peptide transporter PEPT1. J Physiol. 2014;592:871-9 pubmed publisher
    ..different di- and tripeptides is performed by the high-capacity/low-affinity peptide transporter isoform PEPT1 (SLC15A1)...
  74. Arakawa H, Saito S, Kanagawa M, Kamioka H, Yano K, Morimoto K, et al. Evaluation of a thiodipeptide, L-phenylalanyl-?[CS-N]-L-alanine, as a novel probe for peptide transporter 1. Drug Metab Pharmacokinet. 2014;29:470-4 pubmed publisher
    L-Phenylalanyl-?[CS-N]-l-alanine (Phe-?-Ala), a thiourea dipeptide, was evaluated as a probe for peptide transporter 1 (PEPT1)...
  75. Arakawa H, Washio I, Matsuoka N, Kubo H, Staub A, Nakamichi N, et al. Usefulness of kidney slices for functional analysis of apical reabsorptive transporters. Sci Rep. 2017;7:12814 pubmed publisher
    ..Moreover, uptake of PepT1/2 substrate glycyl-sarcosine, was higher than that in the presence of glycyl-leucine, a non-specific Pept ..
  76. Vavricka S, Musch M, Fujiya M, Kles K, Chang L, Eloranta J, et al. Tumor necrosis factor-alpha and interferon-gamma increase PepT1 expression and activity in the human colon carcinoma cell line Caco-2/bbe and in mouse intestine. Pflugers Arch. 2006;452:71-80 pubmed
    A major mechanism for apical peptide absorption by small intestine is via the proton-coupled transporter PepT1. PepT1 is expressed at a high level in proximal small intestine, but it is not expressed in the healthy colon...
  77. Xia C, Milton M, Gan L. Evaluation of drug-transporter interactions using in vitro and in vivo models. Curr Drug Metab. 2007;8:341-63 pubmed
    ..investigate the interactions between drugs and transporters such as P-gp, MRP, BCRP, BSEP, OAT, OATP, OCT, NTCP, PEPT1/2 and NT...
  78. Agu R, Cowley E, Shao D, MacDonald C, Kirkpatrick D, Renton K, et al. Proton-coupled oligopeptide transporter (POT) family expression in human nasal epithelium and their drug transport potential. Mol Pharm. 2011;8:664-72 pubmed publisher
    The molecular and functional expression of peptide transporters (PEPT1 and PEPT2, PHT1, PHT2) in human nasal epithelium was investigated...
  79. Geillinger K, Kuhlmann K, Eisenacher M, Giesbertz P, Meyer H, Daniel H, et al. Intestinal amino acid availability via PEPT-1 affects TORC1/2 signaling and the unfolded protein response. J Proteome Res. 2014;13:3685-92 pubmed publisher
    ..To further elucidate the regulatory network behind the phenotypic alterations in PEPT1-deficient animals, a quantitative proteome analysis combined with transcriptome profiling was applied...
  80. Zhang E, Emerick R, Pak Y, Wrighton S, Hillgren K. Comparison of human and monkey peptide transporters: PEPT1 and PEPT2. Mol Pharm. 2004;1:201-10 pubmed
    Human proton-dependent peptide transporters, PEPT1 and PEPT2, mediate the cellular uptake of di- and tripeptides as well as a variety of drug molecules...
  81. Matsumura K, Miki T, Jhomori T, Gonoi T, Seino S. Possible role of PEPT1 in gastrointestinal hormone secretion. Biochem Biophys Res Commun. 2005;336:1028-32 pubmed
    ..In this study, we show that transfection of oligopeptide transporter 1 (PEPT1) in STC-1 cells, a murine enteroendocrine cell line, evokes di-peptide-stimulated hormone secretion in a pH-..
  82. Thorn K, Andersen R, Christensen J, Jakobsen P, Nielsen C, Steffansen B, et al. Design, synthesis, and evaluation of tripeptidic promoieties targeting the intestinal peptide transporter hPEPT1. ChemMedChem. 2007;2:479-87 pubmed
    The human intestinal proton coupled di/tri-peptide transporter hPEPT1 promotes the oral bioavailability of several drug compounds...
  83. Knutter I, Wollesky C, Kottra G, Hahn M, Fischer W, Zebisch K, et al. Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008;327:432-41 pubmed publisher
    ..Even though the conclusions drawn from published data are quite inconsistent, in most review articles PEPT1 is claimed to mediate the intestinal absorption of ACE inhibitors and thus to determine their oral availability...
  84. Ayyadurai S, Charania M, Xiao B, Viennois E, Zhang Y, Merlin D. Colonic miRNA expression/secretion, regulated by intestinal epithelial PepT1, plays an important role in cell-to-cell communication during colitis. PLoS ONE. 2014;9:e87614 pubmed publisher
    b>PepT1 is a member of the proton-oligopeptide cotransporter family SLC15, which mediates the transport of di/tripeptides from intestinal lumen into epithelial cells...
  85. Biegel A, Gebauer S, Hartrodt B, Brandsch M, Neubert K, Thondorf I. Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005;48:4410-9 pubmed
    The utilization of the membrane transport protein PEPT1 as a drug delivery system is a promising strategy to enhance the oral bioavailability of drugs...
  86. Irie M, Terada T, Tsuda M, Katsura T, Inui K. Prediction of glycylsarcosine transport in Caco-2 cell lines expressing PEPT1 at different levels. Pflugers Arch. 2006;452:64-70 pubmed
    H(+)-coupled peptide transporter 1 (PEPT1) and the basolateral peptide transporter mediate the absorption of small peptides and peptide-like drugs in the small intestine...
  87. Dalmasso G, Nguyen H, Yan Y, Laroui H, Charania M, Obertone T, et al. MicroRNA-92b regulates expression of the oligopeptide transporter PepT1 in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2011;300:G52-9 pubmed publisher
    ..The epithelial di/tripeptide membrane transporter PepT1 is expressed in highly differentiated cells (the villous tip) but not in undifferentiated cells (the crypt) of the ..
  88. Khomane K, Nandekar P, Wahlang B, Bagul P, Shaikh N, Pawar Y, et al. Mechanistic insights into PEPT1-mediated transport of a novel antiepileptic, NP-647. Mol Pharm. 2012;9:2458-68 pubmed publisher
    ..and, in particular, to understand whether it is a substrate for the intestinal oligopeptide transporter, PEPT1 (SLC15A1). NP-647 showed a carrier-mediated, saturable transport with Michaelis-Menten parameters K(m) = 1...
  89. Kaminski N, Wong E. Differential mRNA expression of nutrient transporters in male and female chickens. Poult Sci. 2017;: pubmed publisher
    ..The mRNA abundance of aminopeptidase N (APN), a peptide (PepT1), 6 amino acid transporters (ASCT1, bo,+AT, CAT1, EAAT3, LAT1, and y+LAT2), and 3 monosaccharide (GLUT2, GLUT5, ..
  90. Walker D, Thwaites D, Simmons N, Gilbert H, Hirst B. Substrate upregulation of the human small intestinal peptide transporter, hPepT1. J Physiol. 1998;507 ( Pt 3):697-706 pubmed
    ..by studying the response to the substrate glycyl-L-glutamine (Gly-Gln) of the proton-coupled peptide transporter, hPepT1, in the Caco-2 human intestinal cell line. Vmax for apical uptake of [14C]glycyl-[14C]sarcosine was increased 1...
  91. Daniel H, Kottra G. The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. Pflugers Arch. 2004;447:610-8 pubmed
    ..The prototype transporters of this family are PEPT1 (SLC15A1) and PEPT2 (SLC15A2), which mediate the uptake of peptide substrates into intestinal and renal epithelial cells...
  92. Geissler S, Hellwig M, Zwarg M, Markwardt F, Henle T, Brandsch M. Transport of the advanced glycation end products alanylpyrraline and pyrralylalanine by the human proton-coupled peptide transporter hPEPT1. J Agric Food Chem. 2010;58:2543-7 pubmed publisher
    ..The human intestinal peptide transporter hPEPT1 was transiently expressed in HeLa cells...