SLC13A3

Summary

Gene Symbol: SLC13A3
Description: solute carrier family 13 member 3
Alias: NADC3, SDCT2, solute carrier family 13 member 3, Na(+)/dicarboxylate cotransporter 3, hNaDC3, naDC-3, sodium-dependent high affinity dicarboxylate transporter 3
Species: human
Products:     SLC13A3

Top Publications

  1. Wang H, Fei Y, Kekuda R, Yang Feng T, Devoe L, Leibach F, et al. Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter. Am J Physiol Cell Physiol. 2000;278:C1019-30 pubmed
    We have cloned and functionally characterized the human Na(+)-dependent high-affinity dicarboxylate transporter (hNaDC3) from placenta. The hNaDC3 cDNA codes for a protein of 602 amino acids with 12 transmembrane domains...
  2. Idborg H, Zandian A, Sandberg A, Nilsson B, Elvin K, Truedsson L, et al. Two subgroups in systemic lupus erythematosus with features of antiphospholipid or Sjögren's syndrome differ in molecular signatures and treatment perspectives. Arthritis Res Ther. 2019;21:62 pubmed publisher
    ..Proteins with the lowest p values comparing the two SLE subgroups were ITGB1, SLC13A3, and CERS5...
  3. Brauburger K, Burckhardt G, Burckhardt B. The sodium-dependent di- and tricarboxylate transporter, NaCT, is not responsible for the uptake of D-, L-2-hydroxyglutarate and 3-hydroxyglutarate into neurons. J Inherit Metab Dis. 2011;34:477-82 pubmed publisher
    ..via the human organic anion transporters, OAT1 and OAT4, and the sodium-dependent dicarboxylate transporter 3, NaDC3. In neurons, where most of the damage occurs, a sodium-dependent citrate transporter, NaCT, has been identified...
  4. Weber A, Klocker H, Oberacher H, Gnaiger E, Neuwirt H, Sampson N, et al. Succinate Accumulation Is Associated with a Shift of Mitochondrial Respiratory Control and HIF-1α Upregulation in PTEN Negative Prostate Cancer Cells. Int J Mol Sci. 2018;19: pubmed publisher
    ..This study aimed to investigate the role of succinate and its main plasma membrane transporter NaDC3 (sodium-dependent dicarboxylate transporter member 3) in PCa cells and to determine whether targeting succinate ..
  5. Lee J, Shahidullah M, Hotchkiss A, Coca Prados M, Delamere N, Pelis R. A renal-like organic anion transport system in the ciliary epithelium of the bovine and human eye. Mol Pharmacol. 2015;87:697-705 pubmed publisher
    ..mRNA (RT-PCR) and protein (immunoblotting) for OAT1, OAT3, NaDC3, and MRP4 were detected in extracts of the human ciliary body from several donors...
  6. Barat A, Sahoo P, Kumar R, Pande V. Solute carriers (SLCs) identified and characterized from kidney transcriptome of golden mahseer (Tor putitora) (Fam: Cyprinidae). Comp Biochem Physiol B Biochem Mol Biol. 2016;200:54-61 pubmed publisher
    ..The slc5a1, slc5a12, slc12a3, slc13a3, slc22a13 and slc26a6 were highly expressed in kidney...
  7. Schrödter S, Braun M, Syring I, Klümper N, Deng M, Schmidt D, et al. Identification of the dopamine transporter SLC6A3 as a biomarker for patients with renal cell carcinoma. Mol Cancer. 2016;15:10 pubmed publisher
    ..SLC6A3, NPTX2, TNFAIP6, NDUFA4L2, ENPP3, FABP6, SPINK13; downregulation: FXYD4, SLC12A1, KNG1, NPHS2, SLC13A3, GCGR, PLG)...
  8. Huang W, Wang H, Kekuda R, Fei Y, Friedrich A, Wang J, et al. Transport of N-acetylaspartate by the Na(+)-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain. J Pharmacol Exp Ther. 2000;295:392-403 pubmed
    ..We investigated in the present study the ability of NaDC3, a Na(+)-coupled high-affinity dicarboxylate transporter, to transport N-acetylaspartate...
  9. Liu W, Hong Q, Bai X, Fu B, Xie Y, Zhang X, et al. High-affinity Na(+)-dependent dicarboxylate cotransporter promotes cellular senescence by inhibiting SIRT1. Mech Ageing Dev. 2010;131:601-13 pubmed publisher
    ..Meanwhile, the level of SIRT1 activity was down-regulated. In WI38/hNaDC3 cells treated with the activators of SIRT1, aging-related phenotypes induced by NaDC3 were obviously improved...

More Information

Publications20

  1. Bento J, Palmer N, Zhong M, Roh B, Lewis J, Wing M, et al. Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1. Genomics. 2008;92:226-34 pubmed publisher
    ..potassium-chloride cotransporter member 5), CDH22 (cadherin-like 22), ELMO2 (engulfment and cell motility 2), SLC13A3 (sodium-dependent dicarboxylate transporter member 3), and PREX1 (phosphatidylinositol 3,4,5-triphosphate-..
  2. Bai X, Chen X, Feng Z, Hou K, Zhang P, Fu B, et al. Identification of basolateral membrane targeting signal of human sodium-dependent dicarboxylate transporter 3. J Cell Physiol. 2006;206:821-30 pubmed
    Sodium-dependent dicarboxylate transporters (NaDC) include low-affinity NaDC1 and high-affinity NaDC3. Despite high similarities structurally and functionally, both are localized to opposite surfaces of renal tubular cells...
  3. Burckhardt B, Lorenz J, Kobbe C, Burckhardt G. Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions. Am J Physiol Renal Physiol. 2005;288:F792-9 pubmed
  4. Markovich D, Murer H. The SLC13 gene family of sodium sulphate/carboxylate cotransporters. Pflugers Arch. 2004;447:594-602 pubmed
    ..NaSi-1, SLC13A1), the Na(+)-dependent dicarboxylate transporters NaDC-1/SDCT1 (SLC13A2), NaDC-3/SDCT2 (SLC13A3), the sulphate transporter-1 (SUT-1, SLC13A4) and the Na(+)-coupled citrate transporter (NaCT, SLC13A5)...
  5. Kaufhold M, Schulz K, Breljak D, Gupta S, Henjakovic M, Krick W, et al. Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3. Am J Physiol Renal Physiol. 2011;301:F1026-34 pubmed publisher
    ..The released dicarboxylates are recycled by the sodium dicarboxylate cotransporter 3 (NaDC3)...
  6. Schwob E, Hagos Y, Burckhardt G, Burckhardt B. Transporters involved in renal excretion of N-carbamoylglutamate, an orphan drug to treat inborn n-acetylglutamate synthase deficiency. Am J Physiol Renal Physiol. 2014;307:F1373-9 pubmed publisher
    ..as well as organic anion transporters (OATs) working in cooperation with sodium dicarboxylate cotransporter 3 (NaDC3) accept a wide variety of structurally unrelated drugs...
  7. Pajor A. Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. Pflugers Arch. 2006;451:597-605 pubmed
    ..The other members of the family (NaDC1, NaDC3, and NaCT) are transporters for di- and tri-carboxylates including succinate, citrate and alpha-ketoglutarate...
  8. Breljak D, Ljubojevic M, Hagos Y, Micek V, Balen Eror D, Vrhovac Madunić I, et al. Distribution of organic anion transporters NaDC3 and OAT1-3 along the human nephron. Am J Physiol Renal Physiol. 2016;311:F227-38 pubmed publisher
    ..6.3.9), secondary active Na(+)-dicarboxylate cotransporter 3 (NaDC3/SLC13A3), and tertiary active OA transporters (OATs) OAT1/SLC22A6, OAT2/SLC22A7, and OAT3/SLC22A8...
  9. Strungaru M, Footz T, Liu Y, Berry F, Belleau P, Semina E, et al. PITX2 is involved in stress response in cultured human trabecular meshwork cells through regulation of SLC13A3. Invest Ophthalmol Vis Sci. 2011;52:7625-33 pubmed publisher
    ..Solute carrier family 13 sodium-dependent dicarboxylate transporter member 3 (SLC13A3) was identified as 1 of 47 potential PITX2 target genes in ocular cells...
  10. Schorbach L, Krick W, Burckhardt G, Burckhardt B. Glutathione is a low-affinity substrate of the human sodium-dependent dicarboxylate transporter. Nephron Physiol. 2013;124:1-5 pubmed publisher
    ..Uptake of succinate, the reference substrate of hNaDC3, was inhibited by GSH in a dose-dependent manner with an IC50 of 1.88 mM...
  11. Nanayakkara S, Senevirathna S, Abeysekera T, Chandrajith R, Ratnatunga N, Gunarathne E, et al. An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka. J Occup Health. 2014;56:28-38 pubmed
    ..23 × 10(-9) in quantitative trait locus analysis; p=3.73 × 10(-9) in dichotomous analysis) in SLC13A3 (sodium-dependent dicarboxylate transporter member 3)...