SLC13A2

Summary

Gene Symbol: SLC13A2
Description: solute carrier family 13 member 2
Alias: NADC1, NaCT, NaDC-1, SDCT1, solute carrier family 13 member 2, Na(+)-coupled citrate transporter, Na(+)/dicarboxylate cotransporter 1, renal sodium/dicarboxylate cotransporter, solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
Species: human
Products:     SLC13A2

Top Publications

  1. Okamoto N, Aruga S, Matsuzaki S, Takahashi S, Matsushita K, Kitamura T. Associations between renal sodium-citrate cotransporter (hNaDC-1) gene polymorphism and urinary citrate excretion in recurrent renal calcium stone formers and normal controls. Int J Urol. 2007;14:344-9 pubmed
    ..These results suggest that the B allele of I550V polymorphism of hNaDC-1 may be associated with a reduction in urinary citrate excretion and contribute to hypocitraturia in recurrent renal stone formers. ..
  2. Khamaysi A, Anbtawee Jomaa S, Fremder M, Eini Rider H, Shimshilashvili L, Aharon S, et al. Systemic Succinate Homeostasis and Local Succinate Signaling Affect Blood Pressure and Modify Risks for Calcium Oxalate Lithogenesis. J Am Soc Nephrol. 2019;: pubmed publisher
    ..These findings reveal a succinate/citrate homeostatic pathway regulated by IRBIT that affects BP and biochemical risk of calcium oxalate stone formation, thus providing a potential molecular link between hypertension and lithogenesis. ..
  3. Pasquier D, Hadj Henni A, Escande A, Tresch E, Reynaert N, Colot O, et al. Diffusion weighted MRI as an early predictor of tumor response to hypofractionated stereotactic boost for prostate cancer. Sci Rep. 2018;8:10407 pubmed publisher
    ..05). The increase in nADc at M12 was correlated with PSA decrease at M36 (p?=?0.019). Early nADC variation were correlated with late PSA decrease for patients with PCa treated by EBRT. ..
  4. Zacchia M, Tian X, Zona E, Alpern R, Preisig P. Acid Stimulation of the Citrate Transporter NaDC-1 Requires Pyk2 and ERK1/2 Signaling Pathways. J Am Soc Nephrol. 2018;29:1720-1730 pubmed publisher
    ..b>Conclusions Acid stimulation of NaDC-1 activity involves Pyk2/c-Src and Raf1-ERK1/2-p90RSK signaling pathways, but these pathways are not downstream of ET-1/ETB in this process. ..
  5. Udomsilp P, Saepoo S, Ittiwut R, Shotelersuk V, Dissayabutra T, Boonla C, et al. rs11567842 SNP in SLC13A2 gene associates with hypocitraturia in Thai patients with nephrolithiasis. Genes Genomics. 2018;40:965-972 pubmed publisher
    ..The findings suggested that patients with AA genotypes were more susceptible to hypocitraturia than those with GG, hence carrying a higher risk for kidney stone recurrence. ..
  6. Campagno R, Severin M, Nosetto E, Brandoni A, Torres A. Renal expression and urinary excretion of Na+/dicarboxylate cotransporter 1 (NaDC1) in obstructive nephropathy: a candidate biomarker for this pathology. Pflugers Arch. 2018;470:1777-1786 pubmed publisher
    ..the renal expression and function (as urinary citrate excretion) of sodium-dependent dicarboxylate cotransporter (NaDC1) in rats. In addition, we evaluated the urinary excretion of NaDC1 as a candidate biomarker for this pathology...
  7. Fonseca Berzal C, Palmeiro Roldán R, Escario J, Torrado S, Aran V, Torrado Santiago S, et al. Novel solid dispersions of benznidazole: preparation, dissolution profile and biological evaluation as alternative antichagasic drug delivery system. Exp Parasitol. 2015;149:84-91 pubmed publisher
    ..65% and 91.93%, respectively). The results compiled in the present work suggest these solid dispersions as alternative drug delivery systems to improve the limited chemotherapy of Chagas disease. ..
  8. Huang H, Ma M. High Sodium-Induced Oxidative Stress and Poor Anticrystallization Defense Aggravate Calcium Oxalate Crystal Formation in Rat Hyperoxaluric Kidneys. PLoS ONE. 2015;10:e0134764 pubmed publisher
  9. Brandoni A, Torres A. Expression of renal Oat5 and NaDC1 transporters in rats with acute biliary obstruction. World J Gastroenterol. 2015;21:8817-25 pubmed publisher
    To examine renal expression of organic anion transporter 5 (Oat5) and sodium-dicarboxylate cotransporter 1 (NaDC1), and excretion of citrate in rats with acute extrahepatic cholestasis...

More Information

Publications29

  1. Moreno Rodríguez A, Torrado Durán S, Molero G, García Rodríguez J, Torrado Santiago S. Efficacy and toxicity evaluation of new amphotericin B micelle systems for brain fungal infections. Int J Pharm. 2015;494:17-22 pubmed publisher
    ..AmB:NaDC 1:0.8 and 1:1...
  2. Osis G, Handlogten M, Lee H, Hering Smith K, Huang W, Romero M, et al. Effect of NBCe1 deletion on renal citrate and 2-oxoglutarate handling. Physiol Rep. 2016;4: pubmed publisher
  3. Lin Y, Yu M, Lin S, Lee S, Chen C, Chen D, et al. Genome-wide association analysis identifies a GLUL haplotype for familial hepatitis B virus-related hepatocellular carcinoma. Cancer. 2017;123:3966-3976 pubmed publisher
    ..2 (solute carrier family 13 member 2 [SLC13A2]/forkhead box N1 [FOXN1])...
  4. Slawinska A, Plowiec A, Siwek M, Jaroszewski M, Bednarczyk M. Long-Term Transcriptomic Effects of Prebiotics and Synbiotics Delivered In Ovo in Broiler Chickens. PLoS ONE. 2016;11:e0168899 pubmed publisher
    ..involved in gene expression (PAPOLA, RPL27A, RPLP1, and RPS29) from P1 and P2 in transport (BEST4, SLC9A3, and SLC13A2), metabolism (OGT, ALPP, CA4, and CA7), signaling (FGG, G3BP2, UBB, G3BP2, CACNA1G, and ATP6V0A4), and immune ..
  5. Pajor A, Sun N. Single nucleotide polymorphisms in the human Na+-dicarboxylate cotransporter affect transport activity and protein expression. Am J Physiol Renal Physiol. 2010;299:F704-11 pubmed publisher
    ..citric acid cycle intermediates in the intestine and kidney is mediated by the Na(+)-dicarboxylate cotransporter, NaDC1. In the kidney, NaDC1 plays an important role in regulating succinate and citrate concentrations in the urine, ..
  6. Colas C, Schlessinger A, Pajor A. Mapping Functionally Important Residues in the Na+/Dicarboxylate Cotransporter, NaDC1. Biochemistry. 2017;56:4432-4441 pubmed publisher
    ..modeled mammalian members of the SLC13 family, including the Na+/dicarboxylate cotransporter NaDC1 (SLC13A2), based on a structure of the bacterial homologue VcINDY in an inward-facing conformation with one sodium ion ..
  7. Pajor A, Sun N. Molecular cloning, chromosomal organization, and functional characterization of a sodium-dicarboxylate cotransporter from mouse kidney. Am J Physiol Renal Physiol. 2000;279:F482-90 pubmed
    ..The gene coding for mNaDC-1, Slc13a2, is found on chromosome 11. The gene is approximately 24.9 kb in length and contains 12 exons...
  8. Inoue K, Zhuang L, Ganapathy V. Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function. Biochem Biophys Res Commun. 2002;299:465-71 pubmed
    This paper describes the cloning and functional characterization of the human Na(+)-coupled citrate transporter (NaCT). The cloned human NaCT shows 77% sequence identity with rat NaCT...
  9. Lee H, Handlogten M, Osis G, Clapp W, Wakefield D, Verlander J, et al. Expression of sodium-dependent dicarboxylate transporter 1 (NaDC1/SLC13A2) in normal and neoplastic human kidney. Am J Physiol Renal Physiol. 2017;312:F427-F435 pubmed publisher
    ..Although luminal dicarboxylate reabsorption via NaDC1 (SLC13A2) is believed to be the primary mechanism regulating renal dicarboxylate transport, the specific localization of ..
  10. Rendina D, De Filippo G, Gianfrancesco F, Muscariello R, Schiano di Cola M, Strazzullo P, et al. Evidence for epistatic interaction between VDR and SLC13A2 genes in the pathogenesis of hypocitraturia in recurrent calcium oxalate stone formers. J Nephrol. 2017;30:411-418 pubmed publisher
    ..The Na+-dicarboxylate cotransporter NaDC1, encoded by the sodium-dicarboxylate cotransporter (SLC13A2) gene, is a major determinant of urinary citrate excretion and its biological functions are regulated also by the ..
  11. Bai X, Chen X, Fen Z, Wu D, Hou K, Cheng G, et al. Expression of EGFP/SDCT1 fusion protein, subcellular localization signal analysis, tissue distribution and electrophysiological function study. Sci China C Life Sci. 2004;47:530-9 pubmed
    Full-length cDNA gene of sodium-dependent dicarboxylate co-transporter protein 1 (SDCT1) is cloned from normal human kidney tissue and inserted into EGFP (enhanced green fluorescent protein) expression vector along with N-terminal and C-..
  12. Pajor A. Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney. Am J Physiol. 1996;270:F642-8 pubmed
  13. Bergeron M, Bürzle M, Kovacs G, Simonin A, Hediger M. Synthesis, maturation, and trafficking of human Na+-dicarboxylate cotransporter NaDC1 requires the chaperone activity of cyclophilin B. J Biol Chem. 2011;286:11242-53 pubmed publisher
    ..stone formation, is controlled mainly by reabsorption via the apical Na(+)-dicarboxylate cotransporter NaDC1 (SLC13A2) in the proximal tubule...
  14. Weerachayaphorn J, Pajor A. Threonine-509 is a determinant of apparent affinity for both substrate and cations in the human Na+/dicarboxylate cotransporter. Biochemistry. 2008;47:1087-93 pubmed
    The Na+/dicarboxylate cotransporter (NaDC1) is involved in the absorption of citric acid cycle intermediates from the lumen of the renal proximal tubule and small intestine...
  15. Wang S, Zhang C, Zhang Z, Qian W, Sun Y, Ji B, et al. Transcriptome analysis in primary colorectal cancer tissues from patients with and without liver metastases using next-generation sequencing. Cancer Med. 2017;6:1976-1987 pubmed publisher
    ..The validation showed that three most significantly upregulated DEGs were HOXD10, UGT2A3, and SLC13A2, whereas the five most significantly downregulated DEGs were SPP1, CXCL8, MMP3, OSM, and CXCL6, respectively...
  16. Pajor A. Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. Pflugers Arch. 2006;451:597-605 pubmed
    ..The other members of the family (NaDC1, NaDC3, and NaCT) are transporters for di- and tri-carboxylates including succinate, citrate and alpha-..
  17. Meinild A, Loo D, Pajor A, Zeuthen T, Wright E. Water transport by the renal Na(+)-dicarboxylate cotransporter. Am J Physiol Renal Physiol. 2000;278:F777-83 pubmed
    ..These results indicate that the renal Na(+)-dicarboxylate cotransporter mediates water transport and, under physiological conditions, may contribute to fluid reabsorption across the proximal tubule...
  18. Mann S, Hart T, Pettenati M, Von Kap Herr C, Holmes R. Assignment of the sodium-dependent dicarboxylate transporter gene (SLC13A2 alias NaDC-1) to human chromosome region 17p11.1-->q11.1 by radiation hybrid mapping and fluorescence in situ hybridization. Cytogenet Cell Genet. 1999;84:89-90 pubmed
  19. Bai L, Pajor A. Expression cloning of NaDC-2, an intestinal Na(+)- or Li(+)-dependent dicarboxylate transporter. Am J Physiol. 1997;273:G267-74 pubmed
    ..The differences in functional properties between NaDC-2 and the structurally related Na(+)-dicarboxylate cotransporters NaDC-1 and hNaDC-1 will form the basis of detailed structure-function studies...
  20. Pajor A, Randolph K. Conformationally sensitive residues in extracellular loop 5 of the Na+/dicarboxylate co-transporter. J Biol Chem. 2005;280:18728-35 pubmed
    ..Conformational changes in the protein affect the accessibility of the residues in extracellular loop 5 and provide further evidence of large-scale changes in the structure of NaDC-1 during the transport cycle. ..