SLC12A2

Summary

Gene Symbol: SLC12A2
Description: solute carrier family 12 member 2
Alias: BSC, BSC2, NKCC1, PPP1R141, solute carrier family 12 member 2, basolateral Na-K-Cl symporter, bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1, protein phosphatase 1, regulatory subunit 141, solute carrier family 12 (sodium/potassium/chloride transporter), member 2, solute carrier family 12 (sodium/potassium/chloride transporters), member 2
Species: human
Products:     SLC12A2

Top Publications

  1. Payne J, Xu J, Haas M, Lytle C, Ward D, Forbush B. Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colon. J Biol Chem. 1995;270:17977-85 pubmed
    ..Flux kinetics were consistent with an electroneutral cotransport of 1Na:1K:2Cl. Preincubation in chloride-free media was necessary to activate fully the expressed cotransporter, suggesting a [Cl]-dependent regulatory mechanism. ..
  2. Dzhala V, Talos D, Sdrulla D, Brumback A, Mathews G, Benke T, et al. NKCC1 transporter facilitates seizures in the developing brain. Nat Med. 2005;11:1205-13 pubmed
    ..The Na(+)-K(+)-2Cl(-) cotransporter (NKCC1) facilitates the accumulation of Cl(-) in neurons...
  3. Vitari A, Thastrup J, Rafiqi F, Deak M, Morrice N, Karlsson H, et al. Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. Biochem J. 2006;397:223-31 pubmed
    ..proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase-1) kinases interact and phosphorylate NKCC1 (Na+-K+-2Cl- co-transporter-1), leading to its activation...
  4. Potkin S, Turner J, Guffanti G, Lakatos A, Fallon J, Nguyen D, et al. A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. Schizophr Bull. 2009;35:96-108 pubmed publisher
    ..at P < 10(-6) for the interaction between the imaging QT and the diagnosis (ROBO1-ROBO2, TNIK, and CTXN3-SLC12A2). Three other genes had a significant SNP at <10(-6) (POU3F2, TRAF, and GPC1)...
  5. Somasekharan S, TANIS J, Forbush B. Loop diuretic and ion-binding residues revealed by scanning mutagenesis of transmembrane helix 3 (TM3) of Na-K-Cl cotransporter (NKCC1). J Biol Chem. 2012;287:17308-17 pubmed publisher
    ..We examined the functional role of transmembrane helix 3 (TM3) in NKCC1 using cysteine- and tryptophan-scanning mutagenesis and analyzed our results in the context of a structural ..
  6. Haas M, Forbush B. The Na-K-Cl cotransporters. J Bioenerg Biomembr. 1998;30:161-72 pubmed
    ..The NKCC1 (CCC1, BSC2) isoform is present in a wide variety of tissues; most epithelia containing NKCC1 are secretory ..
  7. Garzon Muvdi T, Schiapparelli P, Ap Rhys C, Guerrero Cazares H, Smith C, Kim D, et al. Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation. PLoS Biol. 2012;10:e1001320 pubmed publisher
    ..Although it has been suggested that the electroneutral Na(+)-K(+)-Cl(-) cotransporter 1 (NKCC1) can play a role in glioma cell migration, the precise mechanism by which this ion transporter contributes to GB ..
  8. Hung C, Peng C, Wu C, Huang K. Bumetanide attenuates acute lung injury by suppressing macrophage activation. Biochem Pharmacol. 2018;156:60-67 pubmed publisher
    ..loop diuretic that acts as an inhibitor of sodium-potassium-chloride cotransporter 2 (NKCC2) and its isoform NKCC1. Although the expression of NKCC2 is limited to the kidney, NKCC1 is widely expressed in various cells, where it ..
  9. Ilkhanizadeh S, Sabelström H, Miroshnikova Y, Frantz A, Zhu W, Idilli A, et al. Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma. Mol Cancer Res. 2018;16:777-790 pubmed publisher
    ..of GBM cells, an effect that was phenocopied in vitro by the sodium-potassium-chloride cotransporter 1 (SLC12A2/NKCC1) inhibitor bumetanide. As a result, AF induced apoptosis and increased survival in GBM models...

More Information

Publications133 found, 100 shown here

  1. Li B, Meng C, Zhang X, Cong D, Gao X, Gao W, et al. Effect of photodynamic therapy combined with torasemide on the expression of matrix metalloproteinase 2 and sodium-potassium-chloride cotransporter 1 in rat peritumoral edema and glioma. Oncol Lett. 2016;11:2084-2090 pubmed
    ..MMP2 and NKCC1 expression levels were detected in the tissues using immunohistochemistry and western blot analysis...
  2. Antoine M, Vijayakumar S, McKeehan N, Jones S, Hebert J. The Severity of Vestibular Dysfunction in Deafness as a Determinant of Comorbid Hyperactivity or Anxiety. J Neurosci. 2017;37:5144-5154 pubmed publisher
    ..Furthermore, we show that (1) inner ear dysfunction due to the tissue-specific loss of Tbx1 or Slc12a2, which encodes a sodium-potassium-chloride cotransporter and is also necessary for inner ear function, causes ..
  3. Park S, Ku S, Ji H, Choi J, Shin D. Ca(2+) is a Regulator of the WNK/OSR1/NKCC Pathway in a Human Salivary Gland Cell Line. Korean J Physiol Pharmacol. 2015;19:249-55 pubmed publisher
    ..as sodium-chloride cotransporter, potassium-chloride cotransporter, and sodium-potassium-chloride cotransporter 1 (NKCC1) through the phosphorylation of oxidative stress responsive kinase 1 (OSR1) and STE20/SPS1-related proline/alanine-..
  4. Begum G, Yuan H, Kahle K, Li L, Wang S, Shi Y, et al. Inhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke. Stroke. 2015;46:1956-1965 pubmed publisher
    ..Ischemia-induced stimulation of the bumetanide-sensitive Na(+)-K(+)-Cl(-) cotransporter (NKCC1) plays an important role in the pathophysiology of experimental stroke, but the mechanism of its regulation in ..
  5. Blanquie O, Liebmann L, Hübner C, Luhmann H, Sinning A. NKCC1-Mediated GABAergic Signaling Promotes Postnatal Cell Death in Neocortical Cajal-Retzius Cells. Cereb Cortex. 2017;27:1644-1659 pubmed publisher
    ..Blockade of the Na-K-Cl transporter NKCC1 in vitro or its genetic deletion in vivo rescued CRNs from apoptosis...
  6. Zhang J, Xu C, Puentes D, Seubert C, Gravenstein N, Martynyuk A. Role of Steroids in Hyperexcitatory Adverse and Anesthetic Effects of Sevoflurane in Neonatal Rats. Neuroendocrinology. 2016;103:440-51 pubmed publisher
    ..These estradiol-enhanced seizures and spikes were depressed by ICI 182780 and the NKCC1 inhibitor, bumetanide, while RU 28318 decreased seizures only...
  7. Zou Y, Yuan Y, Kan E, Lu J, Ling E. Combustion smoke-induced inflammation in the olfactory bulb of adult rats. J Neuroinflammation. 2014;11:176 pubmed publisher
    ..endothelial nitric oxide synthase (eNOS), neuronal nitric oxide synthase (nNOS), Na+-K+-Cl- cotransporter 1 (NKCC1), glial fibrillary acidic protein (GFAP), and aquaporin-4 (AQP4) were evaluated by Western blot analysis...
  8. Ju L, Yang J, Gravenstein N, Seubert C, Morey T, Sumners C, et al. Role of environmental stressors in determining the developmental outcome of neonatal anesthesia. Psychoneuroendocrinology. 2017;81:96-104 pubmed publisher
    ..P) 4, 5, or 6, Sprague-Dawley rats, pretreated with vehicle or the Na+-K+-2Cl- (NKCC1) inhibitor, bumetanide, received two injections of etomidate resulting in anesthesia for 2h...
  9. Miyazaki H, Wangemann P, Marcus D. The gastric H,K-ATPase in stria vascularis contributes to pH regulation of cochlear endolymph but not to K secretion. BMC Physiol. 2016;17:1 pubmed publisher
    ..by amiloride, dimethylamiloride (DMA), S3226 and Hoe694, b) by inhibition of Na,2Cl,K-cotransporter (NKCC1) by bumetanide, and c) by the likely inhibition of HCO3/anion exchange by DIDS...
  10. Gao Y, Zhou J, Zhu Y, Kosten T, Li D. Chronic Unpredictable Mild Stress Induces Loss of GABA Inhibition in Corticotrophin-Releasing Hormone-Expressing Neurons through NKCC1 Upregulation. Neuroendocrinology. 2017;104:194-208 pubmed publisher
    ..CUMS induced a long-lasting increase in expression levels of the cation chloride cotransporter Na+-K+-Cl--Cl- (NKCC1) in the PVN but a transient decrease in expression levels of K+-Cl--Cl- in the PVN, which returned to the basal ..
  11. Yang J, Ju L, Jia M, Zhang H, Sun X, Ji M, et al. Subsequent maternal separation exacerbates neurobehavioral abnormalities in rats neonatally exposed to sevoflurane anesthesia. Neurosci Lett. 2017;661:137-142 pubmed publisher
    ..subgroups of P6 rats received a single injection of the Na+-K+-2Cl- (NKCC1) inhibitor, bumetanide, prior to initiation of anesthesia with sevoflurane...
  12. Simard J, Kahle K, Gerzanich V. Molecular mechanisms of microvascular failure in central nervous system injury--synergistic roles of NKCC1 and SUR1/TRPM4. J Neurosurg. 2010;113:622-9 pubmed publisher
    ..cells as critical mediators of edema formation: the constitutively expressed Na(+)-K(+)-2Cl(-) cotransporter, NKCC1, and the trauma/ischemia-induced SUR1-regulated NC(Ca-ATP) (SUR1/TRPM4) channel...
  13. Ramón M, Salces Ortiz J, González C, Pérez Guzmán M, Garde J, García Álvarez O, et al. Influence of the temperature and the genotype of the HSP90AA1 gene over sperm chromatin stability in Manchega Rams. PLoS ONE. 2014;9:e86107 pubmed publisher
    ..Ridge regression analyses showed that days 29 to 35 and 7 to 14 before sperm collection (bsc) were the most critical regarding the effect of heat stress over DFI values...
  14. Hu D, Yu Z, Zhang Y, Han Y, Zhang W, Lu L, et al. Bumetanide treatment during early development rescues maternal separation-induced susceptibility to stress. Sci Rep. 2017;7:11878 pubmed publisher
    ..in adolescent rats, increased the expression of Na+/K+/2Cl- cotransporter 1 (NKCC1) on postnatal day 14, and increased the expression of K+/2Cl- cotransporter 2 (KCC2) and γ-..
  15. Töllner K, Brandt C, Römermann K, Löscher W. The organic anion transport inhibitor probenecid increases brain concentrations of the NKCC1 inhibitor bumetanide. Eur J Pharmacol. 2015;746:167-73 pubmed publisher
    ..of brain disorders, including neonatal seizures, epilepsy, and autism, because the neuronal Na-K-Cl cotransporter NKCC1, which is inhibited by bumetanide, is implicated in the pathophysiology of such disorders...
  16. Wang S, Zhang X, Song C, Xiao T, Zhao M, Zhu G, et al. In vivo effects of bumetanide at brain concentrations incompatible with NKCC1 inhibition on newborn DGC structure and spontaneous EEG seizures following hypoxia-induced neonatal seizures. Neuroscience. 2015;286:203-15 pubmed publisher
    ..effects of gamma-aminobutyric acid (GABA) achieved by the activity of the Na(+)-K(+)-2Cl(-) cotransporter (NKCC1)...
  17. Mandai S, Furukawa S, Kodaka M, Hata Y, Mori T, Nomura N, et al. Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy. Sci Rep. 2017;7:46369 pubmed publisher
    ..Na+-K+-2Cl- cotransporter 1 (NKCC1) is highly expressed in mammalian skeletal muscle, where it contributes to the generation of membrane ion currents ..
  18. Alshahrani S, Alvarez Leefmans F, Di Fulvio M. Expression of the Slc12a1 gene in pancreatic β-cells: molecular characterization and in silico analysis. Cell Physiol Biochem. 2012;30:95-112 pubmed publisher
    The solute carrier protein family 12 group A, member one (Slc12a1) and two (Slc12a2) encode several splice variants of the kidney-specific and the ubiquitous isoforms, respectively, of the bumetanide (BTD)-sensitive Na-dependent K2Cl co-..
  19. Shubin A, Felong T, Schutrum B, Joe D, Ovitt C, Benoit D. Encapsulation of primary salivary gland cells in enzymatically degradable poly(ethylene glycol) hydrogels promotes acinar cell characteristics. Acta Biomater. 2017;50:437-449 pubmed publisher
    ..The expression of acinar phenotypic markers Aqp5 and Nkcc1 was increased in hydrogels that are MMP-degradable compared with other hydrogel compositions...
  20. Lemonnier E, Villeneuve N, Sonie S, Serret S, Rosier A, Roué M, et al. Effects of bumetanide on neurobehavioral function in children and adolescents with autism spectrum disorders. Transl Psychiatry. 2017;7:e1056 pubmed publisher
    In animal models of autism spectrum disorder (ASD), the NKCC1 chloride-importer inhibitor bumetanide restores physiological (Cl-)i levels, enhances GABAergic inhibition and attenuates electrical and behavioral ..
  21. Halonen J, Hinton A, Frisina R, Ding B, Zhu X, Walton J. Long-term treatment with aldosterone slows the progression of age-related hearing loss. Hear Res. 2016;336:63-71 pubmed publisher
    ..adrenal glands and plays a role in the maintenance of key ion pumps, including the Na-K(+)-Cl co-transporter 1 or NKCC1, which is involved in homeostatic maintenance of the endocochlear potential...
  22. Töllner K, Brandt C, Erker T, Löscher W. Bumetanide is not capable of terminating status epilepticus but enhances phenobarbital efficacy in different rat models. Eur J Pharmacol. 2015;746:78-88 pubmed publisher
    ..Bumetanide, which reduces intraneuronal Cl(-) by inhibiting the Cl(-) intruding Na(+), K(+), Cl(-) cotransporter NKCC1, has been reported to interrupt SE induced by kainate in urethane-anesthetized rats, indicating that this diuretic ..
  23. Mu X, Wang H, Cheng X, Yang L, Sun X, Qu H, et al. Inhibition of Nkcc1 promotes axonal growth and motor recovery in ischemic rats. Neuroscience. 2017;365:83-93 pubmed publisher
    Bumetanide is a selective inhibitor of the Na+-K+-Cl--co-transporter 1(NKCC1). We studied whether bumetanide could affect axonal growth and behavioral outcome in stroke rats...
  24. Karimy J, Zhang J, Kurland D, Theriault B, Duran D, Stokum J, et al. Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus. Nat Med. 2017;23:997-1003 pubmed publisher
    ..by TLR4-dependent activation of the Ste20-type stress kinase SPAK, which binds, phosphorylates, and stimulates the NKCC1 co-transporter at the CPE apical membrane...
  25. Montes S, Castro Chávez A, Florian Soto C, Heras Romero Y, Ríos C, Rivera Mancía S. Bumetanide increases manganese accumulation in the brain of rats with liver damage. Eur J Pharmacol. 2016;774:127-34 pubmed publisher
    ..of cirrhotic rats, and we suggested that such effect could be mediated by manganese-elicited activation of the NKCC1 (Na(+)/K(+)/2Cl(-) cotransporter 1)...
  26. Söderström C, Fagerberg S, Brogaard M, Leipziger J, Skals M, Praetorius H. Loop Diuretics Diminish Hemolysis Induced by α-Hemolysin from Escherichia coli. J Membr Biol. 2017;250:301-313 pubmed publisher
    ..Strikingly, HlyA-induced hemolysis is markedly reduced in erythrocytes isolated from NKCC1-deficient (NKCC1-/-) mice compared to controls...
  27. Walcott B, Kahle K, Simard J. Novel treatment targets for cerebral edema. Neurotherapeutics. 2012;9:65-72 pubmed publisher
    ..Novel treatment targets for cerebral edema include the Na(+)-K(+)-2Cl(-) co-transporter (NKCC1) and the SUR1-regulated NC(Ca-ATP) (SUR1/TRPM4) channel...
  28. Weeden C, Chen Y, Ma S, Hu Y, Ramm G, Sutherland K, et al. Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway. PLoS Biol. 2017;15:e2000731 pubmed publisher
    ..Interestingly, polyploidy, a phenomenon associated with genetically unstable cells, was only observed in the human BSC subset...
  29. Callicott J, Feighery E, Mattay V, White M, Chen Q, Baranger D, et al. DISC1 and SLC12A2 interaction affects human hippocampal function and connectivity. J Clin Invest. 2013;123:2961-4 pubmed publisher
    ..We previously reported that SLC12A2-dependent GABA depolarization and DISC1 coregulate hippocampal neuronal development, and 2 SNPs in these genes ..
  30. Socha J, Kepka L, Ghosh S, Roa W, Kumar N, Sinaika V, et al. Outcome of treatment of recurrent glioblastoma multiforme in elderly and/or frail patients. J Neurooncol. 2016;126:493-8 pubmed publisher
    ..multiforme (rGBM) in elderly and/or frail patients remains virtually unexplored, the best supportive care (BSC) only is routinely administered due to the fatal prognosis...
  31. Zhang L, Alfano J, Race D, Dave R. Zero-order release of poorly water-soluble drug from polymeric films made via aqueous slurry casting. Eur J Pharm Sci. 2018;117:245-254 pubmed publisher
    ..Micronized, surface modified particles of griseofulvin, a model drug of BSC class II, were incorporated into aqueous slurry-cast films of different thicknesses (100, 500, 1000, 1500 and 2000â..
  32. Kumar G, Woods B, Hess L, Treat J, Boye M, Bryden P, et al. Cost-effectiveness of first-line induction and maintenance treatment sequences in non-squamous non-small cell lung cancer (NSCLC) in the U.S. Lung Cancer. 2015;89:294-300 pubmed publisher
    ..and $191,270 for gemcitabine+cisplatin→erlotinib versus gemcitabine+cisplatin→best supportive care (BSC), pemetrexed+cisplatin→BSC versus gemcitabine+cisplatin→erlotinib, and for pemetrexed+cisplatinâ†..
  33. Römermann K, Fedrowitz M, Hampel P, Kaczmarek E, Töllner K, Erker T, et al. Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain. Neuropharmacology. 2017;117:182-194 pubmed publisher
    ..to its effects on the kidney but rather mediated by inhibition of the neuronal Na-K-Cl cotransporter isoform NKCC1. However, following systemic administration, brain levels of bumetanide are typically below those needed to ..
  34. Li Y, Zhou Y, Peng L, Zhao Y. Reduced protein expressions of cytomembrane GABAAR?3 at different postnatal developmental stages of rats exposed prenatally to valproic acid. Brain Res. 2017;1671:33-42 pubmed publisher
    ..cotransporter 2 (KCC2), and Na+-K+-Cl- cotransporter 1 (NKCC1) related to inhibition transmission are changed in a sodium valproate-induced rat model of ASD...
  35. Garcia Duitama J, Chayer B, Han A, Garcia D, Oelze M, Cloutier G. Experimental application of ultrafast imaging to spectral tissue characterization. Ultrasound Med Biol. 2015;41:2506-19 pubmed publisher
    ..statistical sampling of fast-moving tissues using spectral-based techniques to derive the backscatter coefficient (BSC) and associated quantitative parameters...
  36. Hwang J, Chan Y. Expressions of ion co-transporter genes in salicylate-induced tinnitus and treatment effects of spirulina. BMC Neurol. 2016;16:159 pubmed publisher
    ..The mRNA expressions of K(+)-Cl(-) co-transporter (KCC2) and Na-K-2Cl co-transporter 1 (NKCC1) genes in the cochlea and brain of mice were evaluated after tinnitus was induced by intraperitoneal injection of ..
  37. Simpson E, Davis S, Thokala P, Breeze P, Bryden P, Wong R. Sipuleucel-T for the Treatment of Metastatic Hormone-Relapsed Prostate Cancer: A NICE Single Technology Appraisal; An Evidence Review Group Perspective. Pharmacoeconomics. 2015;33:1187-94 pubmed publisher
    ..The comparator was abiraterone acetate (AA) or best supportive care (BSC)...
  38. Marunaka Y, Marunaka R, Sun H, Yamamoto T, Kanamura N, Inui T, et al. Actions of Quercetin, a Polyphenol, on Blood Pressure. Molecules. 2017;22: pubmed publisher
    ..e.: (1) quercetin elevates [Cl-]c by activating Na⁺-K⁺-2Cl- cotransporter 1 (NKCC1) in renal epithelial cells contributing to Na⁺ reabsorption via the epithelial Na⁺ channel (ENaC); (2) the ..
  39. Wilms V, Söffgen C, Nothwang H. Differences in molecular mechanisms of K+ clearance in the auditory sensory epithelium of birds and mammals. J Exp Biol. 2017;220:2701-2705 pubmed publisher
    ..Of these, only CLC-K is expressed in avian supporting cells. Instead, they possess NKCC1 to move K+ across the membrane...
  40. van Linde M, Brahm C, De Witt Hamer P, Reijneveld J, Bruynzeel A, Vandertop W, et al. Treatment outcome of patients with recurrent glioblastoma multiforme: a retrospective multicenter analysis. J Neurooncol. 2017;135:183-192 pubmed publisher
    ..treatment (SYST), re-irradiation (RT), re-resection followed by adjuvant treatment (SURG) and best supportive care (BSC). Median OS for all patients was 6.5 months, and median PFS (excluding patients receiving BSC) was 5.5 months...
  41. Ben Ari Y. NKCC1 Chloride Importer Antagonists Attenuate Many Neurological and Psychiatric Disorders. Trends Neurosci. 2017;40:536-554 pubmed publisher
    ..The diuretic highly specific NKCC1 chloride importer antagonist bumetanide (PubChem CID: 2461) efficiently restores low (Cl-)I ..
  42. Strudwick R, Taylor K. An investigation into breast imaging as part of the undergraduate (UG) education of diagnostic radiography students in the UK. Radiography (Lond). 2017;23:141-146 pubmed publisher
    ..was sent online using SurveyMonkey™ to course leaders of all Higher Education Institutions (HEIs) offering BSc (Hons) Diagnostic Radiography courses in the UK...
  43. Ku Y, Chuang Y, Chen C, Lee M, Yang Y, Tang H, et al. Klebsiella pneumoniae Isolates from Meningitis: Epidemiology, Virulence and Antibiotic Resistance. Sci Rep. 2017;7:6634 pubmed publisher
    Klebsiella pneumoniae (KP) resistance to broad-spectrum cephalosporin (BSC) in meningitis is important because of limited therapeutic options...
  44. Edwards T, Fisher C. Antiviral activity of pyrrole-imidazole polyamides against SV40 and BK polyomaviruses. Antiviral Res. 2018;152:68-75 pubmed publisher
    ..Initial studies found that a single treatment of AVP protected SV40-infected BSC-1 cells from cytopathic effect (CPE) for as long as 11 days p.i....
  45. Ramaekers B, Riemsma R, Tomini F, van Asselt T, Deshpande S, Duffy S, et al. Abiraterone Acetate for the Treatment of Chemotherapy-Naïve Metastatic Castration-Resistant Prostate Cancer: An Evidence Review Group Perspective of an NICE Single Technology Appraisal. Pharmacoeconomics. 2017;35:191-202 pubmed publisher
    ..e. best supportive care [BSC]) for chemotherapy-naïve patients with metastatic castration-resistant prostate cancer (mCRPC)...
  46. Blefari M, Martuzzi R, Salomon R, Bello Ruiz J, Herbelin B, Serino A, et al. Bilateral Rolandic operculum processing underlying heartbeat awareness reflects changes in bodily self-consciousness. Eur J Neurosci. 2017;45:1300-1312 pubmed publisher
    ..studies have described several brain regions which process signals related to bodily self-consciousness (BSC) based on the integration of exteroceptive signals (e.g...
  47. García A, Leonardi D, Lamas M. Promising applications in drug delivery systems of a novel β-cyclodextrin derivative obtained by green synthesis. Bioorg Med Chem Lett. 2016;26:602-608 pubmed publisher
    ..To evaluate the suitability of the novel excipient focused to develop oral dosage forms, albendazole, a BSC class II compound, was chosen as a model drug...
  48. Salomon R, Noel J, Łukowska M, Faivre N, Metzinger T, Serino A, et al. Unconscious integration of multisensory bodily inputs in the peripersonal space shapes bodily self-consciousness. Cognition. 2017;166:174-183 pubmed publisher
    ..as occupying a specific location in space (self-location), two main components of bodily self-consciousness (BSC)...
  49. Selvaraj N, Prasad R, Goldstein J, Rao M. Evidence for the presence of cGMP-dependent protein kinase-II in human distal colon and in T84, the colonic cell line. Biochim Biophys Acta. 2000;1498:32-43 pubmed
    ..Both cell preparations express mRNA for CFTR, Na(+)-K(+)-2Cl(-) cotransporter (NKCC1), GCC and PKG-II as detected by RT-PCR...
  50. Kang S, Markowitz G, Kim S, Johnston M, Kadam S. Age- and sex-dependent susceptibility to phenobarbital-resistant neonatal seizures: role of chloride co-transporters. Front Cell Neurosci. 2015;9:173 pubmed publisher
    ..The expression and function of the electroneutral chloride co-transporters KCC2 and NKCC1 influence the anti-seizure efficacy of GABAA-agonists...
  51. Wang S, Ding Y, Ding X, Liu Z, Shen C, Jin B, et al. Effectiveness of ketogenic diet in pentylenetetrazol-induced and kindling rats as well as its potential mechanisms. Neurosci Lett. 2016;614:1-6 pubmed publisher
    ..of two cation chloride co-transporters: K(+)-Cl(-) co-transporter 2 (KCC2) and Na(+)-K(+)-Cl(-) co-transporter 1 (NKCC1)...
  52. Feroci F, Giani I, Baraghini M, Romoli L, Zalla T, Quattromani R, et al. Barbed versus traditional suture for enterotomy closure after laparoscopic right colectomy with intracorporeal mechanical anastomosis: a case-control study. Updates Surg. 2018;70:433-439 pubmed publisher
    ..with intracorporeal mechanical anastomosis and barbed suture enterotomy closure (barbed suture closure-BSC) for adenocarcinoma (with the exception of T4 lesions and metastasis), compared with 47 matched patients who ..
  53. Stevenson M, Pandor A, Hamilton J, Stevens J, Rowntree C, Martyn St James M, et al. Ponatinib for Treating Acute Lymphoblastic Leukaemia: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. Pharmacoeconomics. 2018;36:759-768 pubmed publisher
    ..Best supportive care (BSC) was assumed to produce no disease response...
  54. Watabe T, Xu M, Watanabe M, Nabekura J, Higuchi T, Hori K, et al. Time-controllable Nkcc1 knockdown replicates reversible hearing loss in postnatal mice. Sci Rep. 2017;7:13605 pubmed publisher
    ..We have developed the transgenic mouse line Actin-tTS::Nkcc1 tetO/tetO for manipulatable expression of the cochlear K+ circulation protein, NKCC1...
  55. Ronchi R, Park H, Blanke O. Bodily self-consciousness and its disorders. Handb Clin Neurol. 2018;151:313-330 pubmed publisher
    ..e., bodily self-consciousness: BSC), including signals coming from outside our body (i.e...
  56. Sadeghi T, Loripoor M. Usefulness of 360 degree evaluation in evaluating nursing students in Iran. Korean J Med Educ. 2016;28:195-200 pubmed publisher
    ..February 2015, 28 students who were selected by census from those who were passing the last semester of the Nursing BSc program in Rafsanjan University of Medical Sciences...
  57. Zhang M, Cui Z, Cui H, Wang Y, Zhong C. Astaxanthin protects astrocytes against trauma-induced apoptosis through inhibition of NKCC1 expression via the NF-κB signaling pathway. BMC Neurosci. 2017;18:42 pubmed publisher
    ..Na+-K+-2Cl- co-transporter-1 (NKCC1), an intrinsic membrane protein expressed by many cell types, is activated by various insults, leading to the ..
  58. Volckaert T, Yuan T, Chao C, Bell H, Sitaula A, Szimmtenings L, et al. Fgf10-Hippo Epithelial-Mesenchymal Crosstalk Maintains and Recruits Lung Basal Stem Cells. Dev Cell. 2017;43:48-59.e5 pubmed publisher
    ..Epithelial-derived Wnt7b, then in turn, induces Fgf10 expression in ASMCs, which extends the BSC niche to promote regeneration.
  59. Wall S, Fischer M, Mehta P, Hassell K, Park S. Contribution of the Na+-K+-2Cl- cotransporter NKCC1 to Cl- secretion in rat OMCD. Am J Physiol Renal Physiol. 2001;280:F913-21 pubmed
    In rat kidney the "secretory" isoform of the Na+-K+-2Cl- cotransporter (NKCC1) localizes to the basolateral membrane of the alpha-intercalated cell...
  60. Luealon P, Khempech N, Vasuratna A, Hanvoravongchai P, Havanond P. Cost Effectiveness Analysis of Different Management Strategies between Best Supportive Care and Second-line Chemotherapy for Platinum-resistant or Refractory Ovarian Cancer. Asian Pac J Cancer Prev. 2016;17:799-805 pubmed
    ..Four types of alternative treatment options were evaluated: 1) gemcitabine followed by BSC; 2) pegylated liposomal doxorubicin (PLD) followed by BSC; 3) gemcitabine followed by topotecan; and 4) PLD ..
  61. Kale O, Awodele O. Safety evaluation of Bon-santé cleanser® polyherbal in male Wistar rats. BMC Complement Altern Med. 2016;16:188 pubmed publisher
    ..Thus, Bon-santé cleanser® (BSC) is formulated from these medicinal plants with the intention to boost body hormones and energizes the body...
  62. Chen H, Kintner D, Jones M, Matsuda T, Baba A, Kiedrowski L, et al. AMPA-mediated excitotoxicity in oligodendrocytes: role for Na(+)-K(+)-Cl(-) co-transport and reversal of Na(+)/Ca(2+) exchanger. J Neurochem. 2007;102:1783-1795 pubmed publisher
    We investigated the role of Na(+)-K(+)-Cl(-) co-transporter isoform 1 (NKCC1) and reversal of Na(+)/Ca(2+) exchanger (NCX(rev)) in glutamate-mediated excitotoxicity in oligodendrocytes obtained from rat spinal cords (postnatal day 6-8)...
  63. Li L, Gou C, Li J, Achakzai R, Li X. Cancer of the Liver Italian Program score helps identify potential candidates for transarterial chemoembolization in patients with Barcelona Clinic Liver Cancer stage C. Hepatobiliary Pancreat Dis Int. 2016;15:152-7 pubmed
    ..The remaining patients received best supportive care (BSC, n=100)...
  64. Hertz L, Chen Y. Importance of astrocytes for potassium ion (K+) homeostasis in brain and glial effects of K+ and its transporters on learning. Neurosci Biobehav Rev. 2016;71:484-505 pubmed publisher
    ..operation creates extracellular hypertonicity and cell shrinkage which is reversed by the astrocytic cotransporter NKCC1. Inhibition of Kir channels by activation of specific PKC isotypes may decrease syncytial distribution and enable ..
  65. Weidenfeld S, Kuebler W. Cytokine-Regulation of Na+-K+-Cl- Cotransporter 1 and Cystic Fibrosis Transmembrane Conductance Regulator-Potential Role in Pulmonary Inflammation and Edema Formation. Front Immunol. 2017;8:393 pubmed publisher
    ..The basolateral expressed Na+-K+-2Cl- cotransporter 1 (NKCC1) and the apical Cl- channel cystic fibrosis transmembrane conductance regulator (CFTR) are considered ..
  66. Hagemann M, Henneberg M, Felde V, Berkowicz S, Raanan H, Pade N, et al. Cyanobacterial populations in biological soil crusts of the northwest Negev Desert, Israel - effects of local conditions and disturbance. FEMS Microbiol Ecol. 2016;: pubmed
    ..Cyanobacteria are important BSC organisms, which are responsible for carbon fixation, N2-fixation, and binding of soil via extracellular ..
  67. Dickhoff C, Dahele M, Smit E, Paul M, Senan S, Hartemink K, et al. Patterns of care and outcomes for stage IIIB non-small cell lung cancer in the TNM-7 era: Results from the Netherlands Cancer Registry. Lung Cancer. 2017;110:14-18 pubmed publisher
    ..2%. 22% received best supportive care (BSC)...
  68. Zanou N, Mondin L, Fuster C, Seghers F, Dufour I, de Clippele M, et al. Osmosensation in TRPV2 dominant negative expressing skeletal muscle fibres. J Physiol. 2015;593:3849-63 pubmed publisher
    ..RVI requires the sequential activation of STE20/SPS1-related proline/alanine-rich kinase (SPAK) and NKCC1, a Na(+) -K(+) -Cl(-) cotransporter, allowing ion entry and driving osmotic water flow...
  69. Felton A, Wright N. Simulation in mental health nurse education: The development, implementation and evaluation of an educational innovation. Nurse Educ Pract. 2017;26:46-52 pubmed publisher
    ..the development, implementation and evaluation of a simulated learning experience for final year undergraduate BSc mental health nursing students in the UK...
  70. Mathad M, Rajesh S, Pradhan B. Spiritual Well-Being and Its Relationship with Mindfulness, Self-Compassion and Satisfaction with Life in Baccalaureate Nursing Students: A Correlation Study. J Relig Health. 2019;58:554-565 pubmed publisher
    ..One hundred and forty-five BSc nursing students were recruited from three nursing colleges in Bangalore, Karnataka, India...
  71. Hu J, Zhang Z, Zheng R, Cheng L, Yang M, Li L, et al. On-treatment markers as predictors to guide anti-EGFR MoAb treatment in metastatic colorectal cancer: a systematic review with meta-analysis. Cancer Chemother Pharmacol. 2017;79:275-285 pubmed publisher
    ..who suffered grade 2+ ST could benefit from additional anti-EGFR treatment to chemotherapy or best supportive care (BSC) alone...
  72. Lykke K, Assentoft M, Hørlyck S, Helms H, Stoica A, Toft Bertelsen T, et al. Evaluating the involvement of cerebral microvascular endothelial Na+/K+-ATPase and Na+-K+-2Cl- co-transporter in electrolyte fluxes in an in vitro blood-brain barrier model of dehydration. J Cereb Blood Flow Metab. 2019;39:497-512 pubmed publisher
    ..the current model suggests the luminally expressed Na+-K+-2Cl- co-transporter 1 (NKCC1) as a key component, while the role of the Na+/K+-ATPase remains uninvestigated...
  73. Rossi D, Graziano F, Ugolini M, Dennetta D, Alessandroni P, Catalano V, et al. Weekly docetaxel as second-line therapy in non-small cell lung cancer: a phase II study. Tumori. 2004;90:50-3 pubmed
    ..Two phase III studies documented a survival benefit at 1 year compared to BSC and vinorelbine or ifosfamide...
  74. Russell J. Sodium-potassium-chloride cotransport. Physiol Rev. 2000;80:211-76 pubmed
    ..The other (NKCC1) is found in nearly all cell types...
  75. Panet R, Eliash M, Atlan H. Na+/K+/Cl- cotransporter activates MAP-kinase cascade downstream to protein kinase C, and upstream to MEK. J Cell Physiol. 2006;206:578-85 pubmed
    In this study, we demonstrated that the specific inhibitors of the Na+/K+/Cl- cotransporter (NKCC1), bumetanide and furosemide, inhibited extracellular regulated kinase (ERK) phosphorylation in Balb/c 3T3 fibroblasts, stimulated with a ..
  76. Steffens R, Semrau S, Lahmer G, Putz F, Lettmaier S, Eyüpoglu I, et al. Recurrent glioblastoma: who receives tumor specific treatment and how often?. J Neurooncol. 2016;128:85-92 pubmed publisher
    ..on the incidence of early death and the frequency of tumor-specific treatment (TST) versus best-supportive care (BSC) as well as the outcomes for the different approaches...
  77. Pozdeev V, Lang E, Gorg B, Bidmon H, Shinde P, Kircheis G, et al. TNFα induced up-regulation of Na+,K+,2Cl- cotransporter NKCC1 in hepatic ammonia clearance and cerebral ammonia toxicity. Sci Rep. 2017;7:7938 pubmed publisher
    ..TNFα-deficient mice against an NH4+ load was paralleled by decreased cerebral expression of NKCC1. According to the present observations, inhibition of TNFα formation and/or NKCC1 may be strategies to favorably ..
  78. Thein H, Qiao Y, Zaheen A, Jembere N, Sapisochin G, Chan K, et al. Cost-effectiveness analysis of treatment with non-curative or palliative intent for hepatocellular carcinoma in the real-world setting. PLoS ONE. 2017;12:e0185198 pubmed publisher
    ..TACE+sorafenib, sorafenib alone, and non-sorafenib chemotherapy compared with no treatment or best supportive care (BSC) among patients diagnosed with HCC between 2007 and 2010 in a Canadian setting...
  79. Grubb B, Lee E, Pace A, Koller B, Boucher R. Intestinal ion transport in NKCC1-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2000;279:G707-18 pubmed
    The Na(+)-K(+)-2Cl(-) cotransporter (NKCC1) located on the basolateral membrane of intestinal epithelia has been postulated to be the major basolateral Cl(-) entry pathway...
  80. Helland C, Aarhus M, Knappskog P, Olsson L, Lund Johansen M, Amiry Moghaddam M, et al. Increased NKCC1 expression in arachnoid cysts supports secretory basis for cyst formation. Exp Neurol. 2010;224:424-8 pubmed publisher
    ..Seven genes were expressed in both cysts and controls. The gene encoding the Na(+)-K(+)-2Cl(-) cotransporter NKCC1 was significantly up-regulated in AC. Gene expression data were supported by Western blot...
  81. Klett N, Allen C. Intracellular Chloride Regulation in AVP+ and VIP+ Neurons of the Suprachiasmatic Nucleus. Sci Rep. 2017;7:10226 pubmed publisher
    ..to setting [Cl-]i in these SCN neurons and found that the chloride uptake transporter NKCC1 contributes to [Cl-]i regulation in SCN neurons, but that the KCCs are the primary ..
  82. Villa F, Goebel J, Rafiqi F, Deak M, Thastrup J, Alessi D, et al. Structural insights into the recognition of substrates and activators by the OSR1 kinase. EMBO Rep. 2007;8:839-45 pubmed
    ..present in OSR1- and SPAK-activating kinases (with-no-lysine kinase 1 (WNK1) and WNK4) as well as its substrates (NKCC1 and NKCC2)...
  83. Sun P, Jin Y, Park S, Kim H, Park E, Jheon S, et al. Expression of Na+-K+-2Cl- cotransporter isoform 1 (NKCC1) predicts poor prognosis in lung adenocarcinoma and EGFR-mutated adenocarcinoma patients. QJM. 2016;109:237-44 pubmed publisher
    Sodium-potassium-chloride cotransporter isoform 1 (NKCC1) is an active ions cotransporter and modulates cellular volume and migration. NKCC1 blockers can inhibit cancer cell growth...
  84. Zhu M, Sung T, Kurahashi M, O Kane L, O Driscoll K, Koh S, et al. Na+-K+-Cl- cotransporter (NKCC) maintains the chloride gradient to sustain pacemaker activity in interstitial cells of Cajal. Am J Physiol Gastrointest Liver Physiol. 2016;311:G1037-G1046 pubmed publisher
    ..We found robust expression of Slc12a2 (which encodes an Na+-K+-Cl- cotransporter, NKCC1) and immunohistochemical ..
  85. Marunaka Y. Actions of quercetin, a flavonoid, on ion transporters: its physiological roles. Ann N Y Acad Sci. 2017;1398:142-151 pubmed publisher
    ..Quercetin, a flavonoid, stimulates Na+ -K+ -2Cl- cotransporter 1 (NKCC1), which is one of the most important ion transporters regulating the cytosolic Cl- concentration ([Cl<..
  86. Yang G, Zhou X, An X, Liu X, Zhang Y, Yu D. Synergistic effect of mild hypothermia and the Notch inhibitor DAPT against post stroke seizures. Biomed Pharmacother. 2017;96:675-684 pubmed publisher
    ..synaptic neurotransmission by up-regulating glutamate receptor subunits (GluN2A, GluA1) and the cotransporter, NKCC1, but attenuated inhibitory synaptic neurotransmission by down-regulating gamma amino acid, butyric acid (GABA), ..
  87. Jalali R, Lodder J, Zandieh Doulabi B, Micha D, Melvin J, Catalán M, et al. The Role of Na:K:2Cl Cotransporter 1 (NKCC1/SLC12A2) in Dental Epithelium during Enamel Formation in Mice. Front Physiol. 2017;8:924 pubmed publisher
    ..We investigated whether enamel-producing mouse ameloblasts express NKCCs. Transcripts for Nkcc1 were identified in the mouse dental epithelium by RT-qPCR and NKCC1 protein was immunolocalized in outer ..
  88. Hartmann A, Blaesse P, Kranz T, Wenz M, Schindler J, Kaila K, et al. Opposite effect of membrane raft perturbation on transport activity of KCC2 and NKCC1. J Neurochem. 2009;111:321-31 pubmed publisher
    ..of neurons, the intracellular Cl(-) concentration is set by the activity of the Na(+)-K(+)-2Cl(-) cotransporter (NKCC1) and the K(+)-Cl(-) cotransporter (KCC2)...
  89. Panichareon B, Nakayama K, Iwamoto S, Thurakitwannakarn W, Sukhumsirichart W. Association of CTXN3-SLC12A2 polymorphisms and schizophrenia in a Thai population. Behav Brain Funct. 2012;8:27 pubmed publisher
    ..study (GWAS) combined with brain imaging as a quantitative trait analysis revealed that the SNPs near CTXN3-SLC12A2 region were related to forebrain development and stress response which involved in schizophrenia...
  90. Sengupta S, Tu S, Wedin K, Earnest S, Stippec S, Luby Phelps K, et al. Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity. J Biol Chem. 2012;287:37868-79 pubmed publisher
    ..activated by WNK1, OSR1 and SPAK phosphorylate and stimulate the sodium, potassium, two chloride co-transporters, NKCC1 and NKCC2, and also affect other related ion co-transporters...
  91. Lee J, Chu E. Adherence, Dosing, and Managing Toxicities With Trifluridine/Tipiracil (TAS-102). Clin Colorectal Cancer. 2017;16:85-92 pubmed publisher
    ..In the phase III Randomized, double-blind, phase III Study of TAS-102 plus best supportive care [BSC] versus placebo plus BSC in patients with metastatic colorectal cancer [CRC] refractory to standard chemotherapies (..
  92. Qiu J, Zhu H, Liu P, Wang J, Lu L. Protective effects of dietary polyphenols from black soybean seed coats on islet and renal function in streptozotocin-induced diabetic rats. J Sci Food Agric. 2017;: pubmed publisher
    The aim of this study was to investigate the antidiabetic effects of the crude polyphenol extract (BSCP) from black soybean seed coats (BSC) and the whole flour of BSC and illustrate the mechanism in terms of islet and renal protection.