SLC11A2

Summary

Gene Symbol: SLC11A2
Description: solute carrier family 11 member 2
Alias: AHMIO1, DCT1, DMT1, NRAMP2, natural resistance-associated macrophage protein 2, DMT-1, NRAMP 2, divalent cation transporter 1, solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Species: human
Products:     SLC11A2

Top Publications

  1. Foot N, Dalton H, Shearwin Whyatt L, Dorstyn L, Tan S, Yang B, et al. Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood. 2008;112:4268-75 pubmed publisher
    ..Here we report that the divalent metal ion transporter DMT1, the primary nonheme iron transporter in mammals, is regulated by ubiquitination mediated by the Nedd4 family ..
  2. Hubert N, Hentze M. Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Proc Natl Acad Sci U S A. 2002;99:12345-50 pubmed
    Divalent metal transporter 1 (DMT1) mediates apical iron uptake into duodenal enterocytes and also transfers iron from the endosome into the cytosol after cellular uptake via the transferrin receptor...
  3. Mims M, Guan Y, Pospisilova D, Priwitzerova M, Indrak K, Ponka P, et al. Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload. Blood. 2005;105:1337-42 pubmed
    Divalent metal transporter 1 (DMT1) is a transmembrane protein crucial for duodenal iron absorption and erythroid iron transport...
  4. Beaumont C, Delaunay J, Hetet G, Grandchamp B, de Montalembert M, Tchernia G. Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload. Blood. 2006;107:4168-70 pubmed
    b>DMT1 mediates the pH-dependent uptake of Fe(2+) from the diet in duodenal enterocytes and in most other cells. It transfers iron from the endosomes to the cytosol following the uptake of the transferrin-transferrin receptor complex...
  5. Howitt J, Putz U, Lackovic J, Doan A, Dorstyn L, Cheng H, et al. Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons. Proc Natl Acad Sci U S A. 2009;106:15489-94 pubmed publisher
    ..The divalent metal transporter 1 (DMT1) plays a central role in the regulation of Fe as well as other metals; hence, failure of DMT1 regulation is linked ..
  6. Qian Z, Wu X, Fan M, Yang L, Du F, Yung W, et al. Divalent metal transporter 1 is a hypoxia-inducible gene. J Cell Physiol. 2011;226:1596-603 pubmed publisher
    ..correlation between the expression of hypoxia-inducible factor-1 (HIF-1) alpha and divalent metal transporter 1 (DMT1) in HepG2 cells treated with chemical or physical hypoxia...
  7. Brasse Lagnel C, Karim Z, Letteron P, Bekri S, Bado A, Beaumont C. Intestinal DMT1 cotransporter is down-regulated by hepcidin via proteasome internalization and degradation. Gastroenterology. 2011;140:1261-1271.e1 pubmed publisher
    ..Iron transport was analyzed using ??FeNTA. Expression of Divalent Metal Transporter 1 (DMT1) and ferroportin was evaluated by reverse-transcription quantitative polymerase chain reaction and immunoblotting...
  8. Vidal S, Belouchi A, Cellier M, Beatty B, Gros P. Cloning and characterization of a second human NRAMP gene on chromosome 12q13. Mamm Genome. 1995;6:224-30 pubmed
    ..the isolation and characterization of a cDNA clone corresponding to the second member of the human NRAMP family, NRAMP2. Predicted amino acid sequence analysis of the NRAMP2 polypeptide identifies a polytopic membrane protein highly ..
  9. Mackenzie B, Takanaga H, Hubert N, Rolfs A, Hediger M. Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1). Biochem J. 2007;403:59-69 pubmed
    b>DMT1 (divalent metal-ion transporter 1) is a widely expressed metal-ion transporter that is vital for intestinal iron absorption and iron utilization by most cell types throughout the body, including erythroid precursors...

More Information

Publications116 found, 100 shown here

  1. Garrick M, Zhao L, Roth J, Jiang H, Feng J, Foot N, et al. Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation. Biometals. 2012;25:787-93 pubmed publisher
    Divalent metal ion transporter (DMT1) is the major transporter for iron entrance into mammalian cells and iron exit from endosomes during the transferrin cycle...
  2. Fleming M, Trenor C, Su M, Foernzler D, Beier D, Dietrich W, et al. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet. 1997;16:383-6 pubmed
    ..of a strong candidate gene for mk, and suggest that the phenotype is a consequence of a missense mutation in Nramp2 (ref. 5), a previously identified gene of unknown function...
  3. Tandy S, Williams M, Leggett A, Lopez Jimenez M, Dedes M, Ramesh B, et al. Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane of human intestinal Caco-2 cells. J Biol Chem. 2000;275:1023-9 pubmed
    ..cloning of a divalent cation transporter (DCT1) from rat duodenum and positional cloning of its human homologue, Nramp2. Here we demonstrate that Nramp2 is expressed in the apical membrane of the human intestinal epithelial cell line, ..
  4. Ludwiczek S, Theurl I, Muckenthaler M, Jakab M, Mair S, Theurl M, et al. Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1. Nat Med. 2007;13:448-54 pubmed
    ..Modulation of DMT-1 function by L-type calcium channel blockers emerges as a new pharmacological therapy for the treatment of iron overload disorders. ..
  5. Kelleher T, Ryan E, Barrett S, O Keane C, Crowe J. DMT1 genetic variability is not responsible for phenotype variability in hereditary hemochromatosis. Blood Cells Mol Dis. 2004;33:35-9 pubmed
    ..Divalent metal transport protein (DMT1) on the apical surface of duodenal enterocytes is recognised as the major iron import protein...
  6. Wang D, Song Y, Li J, Wang C, Li F. Structure and metal ion binding of the first transmembrane domain of DMT1. Biochim Biophys Acta. 2011;1808:1639-44 pubmed publisher
    b>DMT1 is an integral membrane protein with 12 putative transmembrane domains. As a divalent metal ion transporter, it plays an important role in metal ion homeostasis from bacteria to human...
  7. Tabuchi M, Tanaka N, Nishida Kitayama J, Ohno H, Kishi F. Alternative splicing regulates the subcellular localization of divalent metal transporter 1 isoforms. Mol Biol Cell. 2002;13:4371-87 pubmed
    Divalent metal transporter 1 (DMT1) is responsible for dietary-iron absorption from apical plasma membrane in the duodenum and iron acquisition from the transferrin cycle endosomes in peripheral tissues...
  8. Li Z, Lai Z, Ya K, Fang D, Ho Y, Lei Y, et al. Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells. J Cell Mol Med. 2008;12:569-79 pubmed publisher
    ..Divalent metal transporter 1 (DMT1) is also a key transporter of iron under physiological conditions...
  9. Arroyo J, Hosseini A, Zhou Z, Alharthi A, Trevisi E, Osorio J, et al. Reticulo-rumen mass, epithelium gene expression, and systemic biomarkers of metabolism and inflammation in Holstein dairy cows fed a high-energy diet. J Dairy Sci. 2017;100:9352-9360 pubmed publisher
    ..5-fold and downregulated a volatile fatty acid transporter (SLC16A1) and a Fe and Cu transporter (SLC11A2)...
  10. Kühn L. Iron regulatory proteins and their role in controlling iron metabolism. Metallomics. 2015;7:232-43 pubmed publisher
    ..splice variants of iron transporters for import and export at the plasma-membrane, divalent metal transporter 1 (DMT1) and ferroportin are regulated by IRPs...
  11. Guo C, Hao L, Yang Z, Chai R, Zhang S, Gu Y, et al. Deferoxamine-mediated up-regulation of HIF-1α prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice. Exp Neurol. 2016;280:13-23 pubmed publisher
    ..and down-regulated the expression of α-synuclein, divalent metal transporter with iron-responsive element (DMT1+IRE), and transferrin receptor (TFR)...
  12. Linehan W, Rouault T. Molecular pathways: Fumarate hydratase-deficient kidney cancer--targeting the Warburg effect in cancer. Clin Cancer Res. 2013;19:3345-52 pubmed publisher
    ..energy sensor, are decreased resulting in diminished p53 levels, decreased expression of the iron importer, DMT1, leading to low cellular iron levels, and to enhanced fatty acid synthesis by diminishing phosphorylation of acetyl ..
  13. Jain M, Joharapurkar A, Patel V, Kshirsagar S, Sutariya B, Patel M, et al. Pharmacological inhibition of prolyl hydroxylase protects against inflammation-induced anemia via efficient erythropoiesis and hepcidin downregulation. Eur J Pharmacol. 2019;843:113-120 pubmed publisher
    ..increase in expression of Duodenal cytochrome B (DcytB), ferroportin (FPN1) and divalent metal transporter 1 (DMT1) in duodenum, and FPN1 and monocyte chemoattractant protein-1 (MCP-1) in liver suggesting an overall influence on ..
  14. Gulec S, Collins J. Investigation of iron metabolism in mice expressing a mutant Menke's copper transporting ATPase (Atp7a) protein with diminished activity (Brindled; Mo (Br) (/y) ). PLoS ONE. 2013;8:e66010 pubmed publisher
    ..g. Dmt1, Dcytb, Fpn1)...
  15. Espart A, Artime S, Tort Nasarre G, Yara Varón E. Cadmium exposure during pregnancy and lactation: materno-fetal and newborn repercussions of Cd(ii), and Cd-metallothionein complexes. Metallomics. 2018;10:1359-1367 pubmed publisher
    ..the amount of Zn ions available to be transported to the fetus by means of Zn transporters such as ZnT2, ZIP14 and DMT1. Although MTs cannot transport Cd from the mother to the fetus, the divalent DMT1 transporter is suggested to carry ..
  16. Zetzsche A, Schunter N, Zentek J, Pieper R. Accumulation of copper in the kidney of pigs fed high dietary zinc is due to metallothionein expression with minor effects on genes involved in copper metabolism. J Trace Elem Med Biol. 2016;35:1-6 pubmed publisher
    ..and ZIP4, genes involved in Cu metabolism (Ctr1, Atox1, SOD1, ATP7A, CCS, CP) and divalent metal ion transport (DMT1) and binding (MT-1a, MT-2b, MT-3) were determined...
  17. Xie W, Lorenz S, Dolder S, Hofstetter W. Extracellular Iron is a Modulator of the Differentiation of Osteoclast Lineage Cells. Calcif Tissue Int. 2016;98:275-83 pubmed publisher
    ..osteoclasts, levels of transcripts encoding transferrin receptor 1 and divalent metal transporter 1 (Slc11A2) were increased, while levels of transcripts encoding ferroportin (Slc40A1) and natural resistance-associated ..
  18. Lunova M, Schwarz P, Nuraldeen R, Levada K, Kuscuoglu D, Stützle M, et al. Hepcidin knockout mice spontaneously develop chronic pancreatitis owing to cytoplasmic iron overload in acinar cells. J Pathol. 2017;241:104-114 pubmed publisher
    ..acinar iron overload and mild pancreatitis, together with elevated expression of the iron uptake mediators DMT1 and Zip14...
  19. Citelli M, Fonte Faria T, Nascimento Silva V, Renovato Martins M, Silva R, Luna A, et al. Obesity promotes alterations in iron recycling. Nutrients. 2015;7:335-48 pubmed publisher
    ..Serum leptin levels were evaluated. The hepcidin, divalent metal transporter-1 (DMT1), FPN and ferritin genes were analyzed by real-time polymerase chain reaction...
  20. Daher R, Karim Z. Iron metabolism: State of the art. Transfus Clin Biol. 2017;24:115-119 pubmed publisher
    ..In addition, in the enterocytes, hepcidin inhibits the iron influx by acting on the apical transporter, DMT1. A defect of hepcidin expression leading to the appearance of a parenchymal iron overload may be genetic or ..
  21. Xu S, Zhang Y, Wang S, Pang Z, Fan Y, Li J, et al. Lactoferrin ameliorates dopaminergic neurodegeneration and motor deficits in MPTP-treated mice. Redox Biol. 2019;21:101090 pubmed publisher
    ..that Lf suppressed MPTP-induced excessive iron accumulation and the upregulation of divalent metal transporter (DMT1) and transferrin receptor (TFR), which is the main intracellular iron regulation protein, and subsequently improved ..
  22. Owusu Boaitey N, Bauckman K, Zhang T, Mysorekar I. Macrophagic control of the response to uropathogenic E. coli infection by regulation of iron retention in an IL-6-dependent manner. Immun Inflamm Dis. 2016;4:413-426 pubmed
    ..that (1) macrophages upon UPEC infection increased expression of lipocalin 2, a siderophore-binding molecule, of Dmt1, a molecule that facilitates macrophage uptake of free iron, and of the intracellular iron cargo molecule ..
  23. Li H, Jiang S, Yang C, Yang S, He B, Ma W, et al. Long-Term Dexamethasone Exposure Down-Regulates Hepatic TFR1 and Reduces Liver Iron Concentration in Rats. Nutrients. 2017;9: pubmed publisher
    ..00) and the divalent metal transporter 1 (DMT1) (p = 0.04) protein expression, but up-regulated ferroportin (FPN) protein expression (p = 0.04)...
  24. Tunca E, Aydin M, Şahin Ü. Interactions and accumulation differences of metal(loid)s in three sea cucumber species collected from the Northern Mediterranean Sea. Environ Sci Pollut Res Int. 2016;23:21020-21031 pubmed
    ..tubulosa were correlated with all elements (except Pb) in divalent metal transporter 1 (DMT1) (divalent cation transporter 1 (DCT1) or natural resistance-associated macrophage protein 2 (NRAMP2)) belonging to the NRAM protein ..
  25. Kwakye G, Jiménez J, Thomas M, Kingsley B, McIIvin M, Saito M, et al. Heterozygous huntingtin promotes cadmium neurotoxicity and neurodegeneration in striatal cells via altered metal transport and protein kinase C delta dependent oxidative stress and apoptosis signaling mechanisms. Neurotoxicology. 2019;70:48-61 pubmed publisher
    ..significantly greater intracellular accumulation of Cd and reduced expression of divalent metal transporter 1 (DMT1) protein in the heterozygous HTT striatal cells upon Cd exposure...
  26. Urrutia P, Aguirre P, Tapia V, Carrasco C, Mena N, Nunez M. Cell death induced by mitochondrial complex I inhibition is mediated by Iron Regulatory Protein 1. Biochim Biophys Acta Mol Basis Dis. 2017;1863:2202-2209 pubmed publisher
    ..with increased levels of transferrin receptor 1 (TfR1) and iron uptake transporter divalent metal transporter 1 (DMT1), and decreased levels of iron efflux transporter Ferroportin 1 (FPN1), together with increased 55Fe ..
  27. Guo C, Zhang Y, Wang T, Zhong M, Yang Z, Hao L, et al. Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1α pathway on the brain of APP/PS1 transgenic mice. Front Aging Neurosci. 2015;7:104 pubmed publisher
    ..that are encoded from HIF-1-adaptive genes, including transferrin receptor (TFR), divalent metal transporter 1 (DMT1), and brain-derived neurotrophic factor (BDNF)...
  28. Jiang R, Hua C, Wan Y, Jiang B, Hu H, Zheng J, et al. Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain. J Nutr. 2015;145:1003-9 pubmed publisher
    ..Gene expression of divalent metal transporter 1 (Dmt1), ferroportin 1 (Fpn1), Heph, Cp, and transferrin receptor 1 (Tfrc) and HEPH protein level was quantitated in the ..
  29. Jing T, Wang P, Liu Y, Zhao J, Niu X, Wang X. Pathological changes in Sertoli cells and dysregulation of divalent metal transporter 1 with iron responsive element in the testes of idiopathic azoospermia patients. Andrologia. 2018;50: pubmed publisher
    ..We further detected increased levels of iron importer divalent metal transporter 1 with iron responsive element (DMT1 + IRE) in IA testes, whereas the increasing trend of iron exporter ferroportin 1 (FPN1) was not statistically ..
  30. Zhao Y, Zhang L, Yu P, Gou Y, Zhao J, You L, et al. Ceruloplasmin, a Potential Therapeutic Agent for Alzheimer's Disease. Antioxid Redox Signal. 2018;28:1323-1337 pubmed publisher
    ..CP alterations in iron contents were mediated through DMT1(-IRE) and changes in ROS levels, which in turn attenuated the progression of AD through the Erk/p38 and Bcl-2/Bax ..
  31. Zhou S, Du X, Xie J, Wang J. Interleukin-6 regulates iron-related proteins through c-Jun N-terminal kinase activation in BV2 microglial cell lines. PLoS ONE. 2017;12:e0180464 pubmed publisher
    ..Iron regulatory protein 1 (IRP1) and divalent metal transporter 1 (DMT1) were up-regulated and iron exporter ferroportin 1 (FPN1) was down-regulated in BV2 cells after 24 h of IL-6 ..
  32. Li Y, Yu P, Chang S, Wu Q, Yu P, Xie C, et al. Hypobaric Hypoxia Regulates Brain Iron Homeostasis in Rats. J Cell Biochem. 2017;118:1596-1605 pubmed publisher
    ..L-ferritin and iron transport proteins, including transferrin receptor-1 (TfR1), divalent metal transporter 1 (DMT1), and ferroportin1 (FPN1), were also altered...
  33. Zhang Y, Wan D, Zhou X, Long C, Wu X, Li L, et al. Diurnal variations in iron concentrations and expression of genes involved in iron absorption and metabolism in pigs. Biochem Biophys Res Commun. 2017;490:1210-1214 pubmed publisher
    ..Diurnal variations were also observed in transcript levels of divalent metal transporter 1 (DMT1), membrane-associated ferric reductase 1 (DCYTB), and transferrin receptor (TfR) in the duodenum and jejunum, as ..
  34. Gao Y, Xu Y, Wu D, Yu F, Yang L, Yao Y, et al. Progressive silencing of the zinc transporter Zip8 (Slc39a8) in chronic cadmium-exposed lung epithelial cells. Acta Biochim Biophys Sin (Shanghai). 2017;49:444-449 pubmed publisher
    ..The zinc transporters Zip8, Zip14, and divalent metal transporter 1 (Dmt1) are now emerging as several important metal transporters involved in cellular Cd incorporation and their ..
  35. Marambio A, Watkins G, Castro F, Riffo A, Zúñiga R, Jans J, et al. Changes in iron transporter divalent metal transporter 1 in proximal jejunum after gastric bypass. World J Gastroenterol. 2014;20:6534-40 pubmed publisher
    To describe the variation that divalent metal transporter 1 (DMT1) shows in patients after Roux-en-Y gastric bypass (RYGB) surgery...
  36. Giorgi G, D Anna M, Roque M. Iron homeostasis and its disruption in mouse lung in iron deficiency and overload. Exp Physiol. 2015;100:1199-216 pubmed publisher
    ..the lung in whole-animal models with iron deficiency and iron overload, studying the divalent metal transporter 1 (DMT1), ZRT-IRE-like protein 14 (ZIP14), transferrin receptor (TfR), haemochromatosis-associated protein (HFE), hepcidin, ..
  37. Chen F, Luo Z, Fan Y, Wu K, Pan Y, Liu X, et al. Five metal elements homeostasis-related genes in Synechogobius hasta: Molecular characterization, tissue expression and transcriptional response to Cu and Fe exposure. Chemosphere. 2016;159:392-402 pubmed publisher
    ..isoforms of Cu transporter (CTR1 and CTR2) and metallothionein (MT1 and MT2), and divalent metal ion transporter 1 (DMT1) were cloned and characterized in Synechogobius hasta, respectively. The protein sequences of S...
  38. Ferguson C, Wareing M, Ward D, Green R, Smith C, Riccardi D. Cellular localization of divalent metal transporter DMT-1 in rat kidney. Am J Physiol Renal Physiol. 2001;280:F803-14 pubmed
    ..J Physiol (Lond) 524: 581-586, 2000]. To test the possibility that the divalent metal transporter DMT1 (Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, and Hediger MA...
  39. Zhang W, Meng H, Yang M. Regulation of DMT1 on Bone Microstructure in Type 2 Diabetes. Int J Med Sci. 2015;12:441-9 pubmed publisher
    ..Therefore, the present study aimed to explore the function of DMT1 in the pathological process of diabetic osteoporosis...
  40. Nemmiche S, Guiraud P. Cadmium-induced oxidative damages in the human BJAB cells correlate with changes in intracellular trace elements levels and zinc transporters expression. Toxicol In Vitro. 2016;37:169-177 pubmed publisher
    ..Cd exposure increased the expression of DMT1 and caused an up-regulation of ZnT1. However, the T calcium channel alpha1G subunit could not be detected...
  41. Xie L, Collins J. Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2{alpha}) in intestinal epithelial cells. Am J Physiol Cell Physiol. 2011;300:C1298-305 pubmed publisher
    Iron homeostasis-related genes (e.g., Dmt1 and Dcytb) are upregulated by hypoxia-inducible factor 2α (HIF2α) during iron deficiency in the mammalian intestine...
  42. Jiang B, Liu G, Zheng J, Chen M, Maimaitiming Z, Chen M, et al. Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney. Sci Rep. 2016;6:39470 pubmed publisher
    ..Both DMT1 and TfR1 protein expression were significantly decreased in the renal medulla of Heph/Cp KO mice, while the ..
  43. Gerasimenko T, Senyavina N, Anisimov N, Tonevitskaya S. A Model of Cadmium Uptake and Transport in Caco-2 Cells. Bull Exp Biol Med. 2016;161:187-92 pubmed publisher
    ..Transcriptome profiling of Caco-2 cells revealed high content of transporter DMT1 and ZIP14 and intensive expression of some calcium channels of the CACN family...
  44. Andolfo I, De Falco L, Asci R, Russo R, Colucci S, Gorrese M, et al. Regulation of divalent metal transporter 1 (DMT1) non-IRE isoform by the microRNA Let-7d in erythroid cells. Haematologica. 2010;95:1244-52 pubmed publisher
    Divalent metal transporter 1 (DMT1) is a widely expressed metal-iron transporter gene encoding four variant mRNA transcripts, differing for alternative promoter at 5' (DMT1 1A and 1B) and alternative splicing at 3' UTR, differing by a ..
  45. Jung E, Park Y, Woo M, Lee S, Suh H. Hematopoietic effect of fermented deer antler extract in iron deficient diet-induced anemic rats. Chin J Integr Med. 2016;: pubmed
    ..the liver and spleen, hepatic ?-aminolevulinic acid dehydrogenase (ALAD) activity and divalent metal transporter 1 (DMT1) mRNA expression were analyzed...
  46. I Bannon D, Portnoy M, Olivi L, Lees P, Culotta V, Bressler J. Uptake of lead and iron by divalent metal transporter 1 in yeast and mammalian cells. Biochem Biophys Res Commun. 2002;295:978-84 pubmed
    Although the divalent metal transporter (DMT1) was suggested to transport a wide range of metals in Xenopus oocytes, recent studies in other models have provided contrasting results...
  47. Zoller H, Decristoforo C, Weiss G. Erythroid 5-aminolevulinate synthase, ferrochelatase and DMT1 expression in erythroid progenitors: differential pathways for erythropoietin and iron-dependent regulation. Br J Haematol. 2002;118:619-26 pubmed
    ..These data provide new insights into the complex biochemical interaction between iron metabolism, haem biosynthesis and EPO biology. ..
  48. Li Y, Bai B, Cao X, Zhang Y, Yan H, Zheng Q, et al. Divalent metal transporter 1 expression and regulation in human placenta. Biol Trace Elem Res. 2012;146:6-12 pubmed publisher
    Divalent metal transporter 1 (DMT1) is likely responsible for the release of iron from endosomes to the cytoplasm in placental syncytiotrophoblasts (STB)...
  49. Dubose T. Regulation of Potassium Homeostasis in CKD. Adv Chronic Kidney Dis. 2017;24:305-314 pubmed publisher
    ..information regarding sensors of changes in the serum [K+] that evoke changes in NaCl transport in the DCT1 and subsequent efferent responses by aldosterone-responsive cells in the DCT2 and cortical collecting duct to ..
  50. Li X, Xie J, Lu L, Zhang L, Zhang L, Zou Y, et al. Kinetics of manganese transport and gene expressions of manganese transport carriers in Caco-2 cell monolayers. Biometals. 2013;26:941-53 pubmed publisher
    ..from 0 to 2,500 ?mol/L at 40 and 120 min, respectively, and mRNA levels of divalent metal transporter 1 (DMT1) and ferroportin (FPN1) were determined in Caco-2 cells treated with the medium containing 0 or 800 ?mol/L of Mn ..
  51. Ehrnstorfer I, Geertsma E, Pardon E, Steyaert J, Dutzler R. Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport. Nat Struct Mol Biol. 2014;21:990-6 pubmed publisher
    ..Mutations of interacting residues affect ion binding and transport in both ScaDMT and human DMT1. Our study thus reveals a conserved mechanism for transition-metal ion selectivity within the SLC11 family.
  52. Deng B, Zhou X, Wu J, Long C, Yao Y, Peng H, et al. Effects of dietary supplementation with tribasic zinc sulfate or zinc sulfate on growth performance, zinc content and expression of zinc transporters in young pigs. Anim Sci J. 2017;88:1556-1560 pubmed publisher
    ..performance, serum zinc (Zn) content and messenger RNA (mRNA) expression of Zn transporters (ZnT1/ZnT2/ZnT5/ZIP4/DMT1) of young growing pigs...
  53. Xie L, Collins J. Copper stabilizes the Menkes copper-transporting ATPase (Atp7a) protein expressed in rat intestinal epithelial cells. Am J Physiol Cell Physiol. 2013;304:C257-62 pubmed publisher
    ..g., divalent metal transporter (Dmt1) and ferroportin 1 (Fpn1)]...
  54. Rami Merhar B, Fröhlich Reiterer E, Hofer S. [Diabetes in the youth]. Wien Klin Wochenschr. 2016;128 Suppl 2:S119-23 pubmed publisher
    In contrast to adults diabetes mellitus type 1 (DMT1) is the most frequent form of diabetes mellitus during childhood and adolescence (>?95?%)...
  55. Lu L, Qian Z, Wu K, Yung W, Ke Y. Expression of Iron Transporters and Pathological Hallmarks of Parkinson's and Alzheimer's Diseases in the Brain of Young, Adult, and Aged Rats. Mol Neurobiol. 2017;54:5213-5224 pubmed publisher
    ..and the expression of two major iron importers, transferrin receptor 1 (TfR1) and divalent metal transporter (DMT1), two iron exporters, ferroportin 1 (Fpn1) and ceruloplasmin (CP), and hepcidin, along with the pathological ..
  56. Xu Z, Sun W, Li Y, Ling S, Zhao C, Zhong G, et al. The regulation of iron metabolism by hepcidin contributes to unloading-induced bone loss. Bone. 2017;94:152-161 pubmed publisher
    ..of the upregulation of transferrin receptor 1 (TfR1) and divalent metal transporter 1 with iron response element (DMT1+IRE), rather than changes in the iron transporter ferroportin 1 (FPN1)...
  57. Gao H, Xie W, Yang C, Xu J, Li J, Wang H, et al. NRAMP2, a trans-Golgi network-localized manganese transporter, is required for Arabidopsis root growth under manganese deficiency. New Phytol. 2018;217:179-193 pubmed publisher
    ..Mn transporter nramp1 mutant background in Arabidopsis thaliana and identified an uncharacterized Mn transport NRAMP2. We investigated the effect of nramp2 mutation on root growth and reactive oxygen species (ROS) accumulation and ..
  58. Tabuchi M, Yoshimori T, Yamaguchi K, Yoshida T, Kishi F. Human NRAMP2/DMT1, which mediates iron transport across endosomal membranes, is localized to late endosomes and lysosomes in HEp-2 cells. J Biol Chem. 2000;275:22220-8 pubmed
    b>NRAMP2 (natural resistance-associated macrophage protein 2)/DMT1 (divalent metal transporter 1) is a divalent metal transporter conserved from prokaryotes to higher eukaryotes that exhibits an unusually broad substrate range, including Fe(..
  59. Fu S, O Neal S, Hong L, Jiang W, Zheng W. Elevated adult neurogenesis in brain subventricular zone following in vivo manganese exposure: roles of copper and DMT1. Toxicol Sci. 2015;143:482-98 pubmed publisher
    ..This study was designed to test the hypothesis that Mn exposure by acting on the divalent metal transporter-1 (DMT1) altered Cu levels in SVZ and RMS, thereby affecting adult neurogenesis. Adult rats received intraperitoneal (i.p...
  60. Wade J, Fang L, Coleman R, Liu J, Grimm P, Wang T, et al. Differential regulation of ROMK (Kir1.1) in distal nephron segments by dietary potassium. Am J Physiol Renal Physiol. 2011;300:F1385-93 pubmed publisher
    ..expression along the entire distal nephron than previously thought, localizing to distal convoluted tubule regions, DCT1 and DCT2; the connecting tubule (CNT); and cortical collecting duct (CD)...
  61. Li X, Liao X, Zhang L, Lu L, Luo X. Effect of iron source on iron absorption and gene expression of iron transporters in the ligated duodenal loops of broilers. J Anim Sci. 2017;95:1587-1597 pubmed publisher
    ..to investigate the effect of iron source on Fe absorption and the gene expression of divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) in the ligated duodenal loops of broilers...
  62. Cadieux J, Zhang Z, Mattice M, Brownlie Cutts A, Fu J, Ratkay L, et al. Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1). Bioorg Med Chem Lett. 2012;22:90-5 pubmed publisher
    Three distinct series of substituted pyrazole blockers of divalent metal transporter 1 (DMT1) were elaborated from the high-throughput screening pyrazolone hit 1...
  63. Wang G, Shao A, Hu W, Xue F, Zhao H, Jin X, et al. Changes of ferrous iron and its transporters after intracerebral hemorrhage in rats. Int J Clin Exp Pathol. 2015;8:10671-9 pubmed
    ..Divalent metal transporter1 (DMT1) is the important and well-known plasma membrane transport protein which was proved to be involved in the transport ..
  64. Gruper Y, Bar J, Bacharach E, Ehrlich R. Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells. J Cell Physiol. 2005;204:901-12 pubmed
    ..Several iron transporters and regulators were recently characterized, including DMT1 and ferroportin/Ireg1 that transport iron through membranes, and HFE that regulates TfR-mediated iron uptake...
  65. Pujol Giménez J, Hediger M, Gyimesi G. A novel proton transfer mechanism in the SLC11 family of divalent metal ion transporters. Sci Rep. 2017;7:6194 pubmed publisher
    In humans, the H+-coupled Fe2+ transporter DMT1 (SLC11A2) is essential for proper maintenance of iron homeostasis...
  66. Worthington M, Browne L, Battle E, Luo R. Functional properties of transfected human DMT1 iron transporter. Am J Physiol Gastrointest Liver Physiol. 2000;279:G1265-73 pubmed
    Recently, mutation of the DMT1 gene has been discovered to cause ineffective intestinal iron uptake and abnormal body iron metabolism in the anemic Belgrade rat and mk mouse...
  67. Tallkvist J, Bowlus C, Lonnerdal B. DMT1 gene expression and cadmium absorption in human absorptive enterocytes. Toxicol Lett. 2001;122:171-7 pubmed
    Divalent metal transporter 1 (DMT1) is a transmembrane, proton-coupled metal ion transporter that is upregulated in the duodenum of iron-deficient rodents and in hereditary hemochromatosis patients, suggesting that it may constitute a key ..
  68. Zoller H, Theurl I, Koch R, McKie A, Vogel W, Weiss G. Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis. Gastroenterology. 2003;125:746-54 pubmed
    ..Spearman rank correlations showed that Dcytb, hephaestin, FPN1, and DMT1 mRNA expression are positively related to each other independently of the underlying disease, which ensures an ..
  69. Wolff N, Ghio A, Garrick L, Garrick M, Zhao L, Fenton R, et al. Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1). FASEB J. 2014;28:2134-45 pubmed publisher
    ..Our results show that the divalent metal transporter 1 (DMT1) occurs in the OMM. Immunoblots detected DMT1 in mitochondria from a pneumocyte cell model in their OMM...
  70. Stuart K, Anderson G, Frazer D, Murphy T, Powell L, Fletcher L, et al. Increased duodenal expression of divalent metal transporter 1 and iron-regulated gene 1 in cirrhosis. Hepatology. 2004;39:492-9 pubmed
    ..current study investigated the duodenal expression of the iron transport molecules divalent metal transporter 1 (DMT1 [IRE]), iron-regulated gene 1 (Ireg1 [ferroportin]), hephaestin, and duodenal cytochrome b (Dyctb) in 46 patients ..
  71. Techau M, Valdez Taubas J, Popoff J, Francis R, Seaman M, Blackwell J. Evolution of differences in transport function in Slc11a family members. J Biol Chem. 2007;282:35646-56 pubmed
    ..Slc11a1 (formerly Nramp1) is a proton/divalent cation transporter that regulates cation homeostasis in macrophages. Slc11a2 mediates divalent cation uptake via the gut and delivery into cells...
  72. Espinoza A, Le Blanc S, Olivares M, Pizarro F, Ruz M, Arredondo M. Iron, copper, and zinc transport: inhibition of divalent metal transporter 1 (DMT1) and human copper transporter 1 (hCTR1) by shRNA. Biol Trace Elem Res. 2012;146:281-6 pubmed publisher
    ..To determine the involvement of divalent metal transporter 1 (DMT1) and human copper transporter 1 (hCTR1) on Fe, Cu, and Zn uptake, Caco-2 cells were transfected with four different ..
  73. Xue X, Ramakrishnan S, Weisz K, Triner D, Xie L, Attili D, et al. Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis. Cell Metab. 2016;24:447-461 pubmed publisher
    ..Gene expression and functional studies demonstrated that the cellular iron importer, divalent metal transporter 1 (DMT1), is highly expressed in CRC through hypoxia-inducible factor 2?-dependent transcription...
  74. Yeh K, Yeh M, Watkins J, Rodriguez Paris J, Glass J. Dietary iron induces rapid changes in rat intestinal divalent metal transporter expression. Am J Physiol Gastrointest Liver Physiol. 2000;279:G1070-9 pubmed
    The divalent metal transporter (DMT1, also known as NRAMP2 or DCT1) is the likely target for regulation of intestinal iron absorption by iron stores...
  75. Xiong L, Dion P, Montplaisir J, Levchenko A, Thibodeau P, Karemera L, et al. Molecular genetic studies of DMT1 on 12q in French-Canadian restless legs syndrome patients and families. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:911-7 pubmed
    ..Animal models with mutation in (DMT1) divalent metal transporter 1 gene, an important brain iron transporter, demonstrate a similar iron deficiency ..
  76. Przybyłkowski A, Gromadzka G, Członkowska A. Polymorphisms of metal transporter genes DMT1 and ATP7A in Wilson's disease. J Trace Elem Med Biol. 2014;28:8-12 pubmed publisher
    Wilson's disease (WND) is an inherited disorder of copper metabolism. Divalent metal transporter1 (DMT1) and ATP7A play important roles in metal transport in humans...
  77. Johnson D, Yamaji S, Tennant J, Srai S, Sharp P. Regulation of divalent metal transporter expression in human intestinal epithelial cells following exposure to non-haem iron. FEBS Lett. 2005;579:1923-9 pubmed
    ..factors including dietary iron levels can dramatically alter the expression of the intestinal iron transporter DMT1. Here we show that Caco-2 cells exposed to iron for 4h exhibited a significant decrease in plasma membrane DMT1 ..
  78. De Falco L, Bruno M, Andolfo I, David B, Girelli D, Di Noce F, et al. Identification and characterization of the first SLC11A2 isoform 1a mutation causing a defect in splicing process and an hypomorphic allele expression of the SLC11A2 gene. Br J Haematol. 2012;159:492-5 pubmed publisher
  79. Lee P, Gelbart T, West C, Halloran C, Beutler E. The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms. Blood Cells Mol Dis. 1998;24:199-215 pubmed
    b>Nramp2 is a gene encoding a transmembrane protein that is important in metal transport, in particular iron...
  80. Waheed A, Parkkila S, Saarnio J, Fleming R, Zhou X, Tomatsu S, et al. Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum. Proc Natl Acad Sci U S A. 1999;96:1579-84 pubmed
    ..Impairment of this function caused by HFE gene mutations in HH could provide a paradoxical signal in crypt enterocytes that programs the differentiating enterocytes to absorb more dietary iron when they mature into villus enterocytes. ..
  81. Oates P, Thomas C, Freitas E, Callow M, Morgan E. Gene expression of divalent metal transporter 1 and transferrin receptor in duodenum of Belgrade rats. Am J Physiol Gastrointest Liver Physiol. 2000;278:G930-6 pubmed
    ..cells via the transferrin receptor (TfR)-transferrin cycle and the activity of the divalent metal transporter (DMT1), although DMT1 cannot be detected morphologically in crypt cells...
  82. Anderson G, Frazer D. Current understanding of iron homeostasis. Am J Clin Nutr. 2017;106:1559S-1566S pubmed publisher
    ..iron is transported across the apical membrane of the intestinal enterocyte by divalent metal-ion transporter 1 (DMT1) and is exported into the circulation via ferroportin 1 (FPN1)...
  83. Wysokinski D, Zaras M, Dorecka M, Waszczyk M, Szaflik J, Blasiak J, et al. An association between environmental factors and the IVS4+44C>A polymorphism of the DMT1 gene in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2012;250:1057-65 pubmed publisher
    ..we searched for an association between some single nucleotide polymorphisms in the divalent metal transporter 1 (DMT1) gene intronic IVS4+44C>A (rs224589) and 3'-UTR c.2044T>C (rs2285230) and environmental factors and AMD...
  84. Ingrassia R, Lanzillotta A, Sarnico I, Benarese M, Blasi F, Borgese L, et al. 1B/(-)IRE DMT1 expression during brain ischemia contributes to cell death mediated by NF-?B/RelA acetylation at Lys310. PLoS ONE. 2012;7:e38019 pubmed publisher
    ..hypothesized that the increase of iron through a NF-?B-regulated 1B isoform of the divalent metal transporter-1 (1B/DMT1) might contribute to post-ischemic neuronal damage...
  85. Esparza A, Gerdtzen Z, Olivera Nappa A, Salgado J, Núñez M. Iron-induced reactive oxygen species mediate transporter DMT1 endocytosis and iron uptake in intestinal epithelial cells. Am J Physiol Cell Physiol. 2015;309:C558-67 pubmed publisher
    Recent evidence shows that iron induces the endocytosis of the iron transporter dimetal transporter 1 (DMT1) during intestinal absorption...
  86. Ha J, Doguer C, Collins J. Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells. Metallomics. 2016;8:963-972 pubmed
    ..Expression of Dmt1 (the iron importer), Dcytb (an apical membrane ferrireductase) and Fpn1 (the iron exporter) was decreased in Atp7a ..
  87. Sterling J, Guttha S, Song Y, Song D, Hadziahmetovic M, Dunaief J. Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels. Exp Eye Res. 2017;155:15-23 pubmed publisher
    ..Quantitative RT-PCR and Western analysis were used to quantify the expression of three ferrous iron importers, Dmt1, Zip8, and Zip14, in wild-type (Wt), Cp/Heph DKO, and Hepc KO retinas...
  88. Knutson M, Menzies S, Connor J, Wessling Resnick M. Developmental, regional, and cellular expression of SFT/UbcH5A and DMT1 mRNA in brain. J Neurosci Res. 2004;76:633-41 pubmed
    ..into and within the brain, we have analyzed expression patterns of two factors: divalent metal transporter 1 (DMT1) and stimulator of Fe transport (SFT)...
  89. Nevo Y. Site-directed mutagenesis investigation of coupling properties of metal ion transport by DCT1. Biochim Biophys Acta. 2008;1778:334-41 pubmed
    DCT1 (NRAMP2, DMT1, slc11a2) is a member of the NRAMP family and functions as general metal ion transporter in mammals; defective DCT1 causes anemia...
  90. Costa E, Rocha S, Rocha Pereira P, Reis F, Castro E, Teixeira F, et al. DMT1 (NRAMP2/DCT1) genetic variability and resistance to recombinant human erythropoietin therapy in chronic kidney disease patients under haemodialysis. Acta Haematol. 2008;120:11-3 pubmed publisher
  91. Lonnerdal B. Development of iron homeostasis in infants and young children. Am J Clin Nutr. 2017;106:1575S-1580S pubmed publisher
    ..The major iron transporters in the small intestine divalent metal-ion transporter 1 (DMT1) and ferroportin were not affected by pup iron status at 10 d of age but were strongly affected by iron status at ..
  92. Sharp P, Tandy S, Yamaji S, Tennant J, Williams M, Singh Srai S. Rapid regulation of divalent metal transporter (DMT1) protein but not mRNA expression by non-haem iron in human intestinal Caco-2 cells. FEBS Lett. 2002;510:71-6 pubmed
    A divalent metal transporter, DMT1, located on the apical membrane of intestinal enterocytes is the major pathway for the absorption of dietary non-haem iron...