SLC11A1

Summary

Gene Symbol: SLC11A1
Description: solute carrier family 11 member 1
Alias: LSH, NRAMP, NRAMP1, natural resistance-associated macrophage protein 1, NRAMP 1, solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1, solute carrier family 11 (sodium/phosphate symporters), member 1
Species: human
Products:     SLC11A1

Top Publications

  1. Hatta M, Ratnawati -, Tanaka M, Ito J, Shirakawa T, Kawabata M. NRAMP1/SLC11A1 gene polymorphisms and host susceptibility to Mycobacterium tuberculosis and M. leprae in South Sulawesi, Indonesia. Southeast Asian J Trop Med Public Health. 2010;41:386-94 pubmed
    ..Natural resistance associated macrophage protein1 (Nramp1, alias Slc11a1) gene has been suggested to an associated gene of the host susceptibility to mycobacterium infection...
  2. Searle S, Blackwell J. Evidence for a functional repeat polymorphism in the promoter of the human NRAMP1 gene that correlates with autoimmune versus infectious disease susceptibility. J Med Genet. 1999;36:295-9 pubmed
    A polymorphism in the promoter of human NRAMP1 encodes a Z-DNA forming dinucleotide repeat with four alleles: (1) t(gt)5ac(gt)5ac(gt)11g; (2) t(gt)5ac(gt)5 ac(gt)10g; (3) t(gt)5ac(gt) ac(gt)9g; and (4) t(gt)5ac(gt)9g...
  3. Hsu Y, Chen C, Sun H, Jou R, Lee J, Su I. Association of NRAMP 1 gene polymorphism with susceptibility to tuberculosis in Taiwanese aboriginals. J Formos Med Assoc. 2006;105:363-9 pubmed
    The human homologue of mice natural-resistance-associated macrophage protein 1 (Nramp 1) gene, NRAMP 1, has been reported to play a role in susceptibility to tuberculosis in humans...
  4. Paccagnini D, Sieswerda L, Rosu V, Masala S, Pacifico A, Gazouli M, et al. Linking chronic infection and autoimmune diseases: Mycobacterium avium subspecies paratuberculosis, SLC11A1 polymorphisms and type-1 diabetes mellitus. PLoS ONE. 2009;4:e7109 pubmed publisher
    ..b>SLC11A1 is a membrane transporter that is expressed in late endosomes of antigen presenting cells involved in the ..
  5. Awomoyi A, Marchant A, Howson J, McAdam K, Blackwell J, Newport M. Interleukin-10, polymorphism in SLC11A1 (formerly NRAMP1), and susceptibility to tuberculosis. J Infect Dis. 2002;186:1808-14 pubmed
    ..b>Slc11a1 (formerly Nramp1), the first murine infection susceptibility locus identified, regulates early innate responses ..
  6. Liaw Y, Tsai Wu J, Wu C, Hung C, Lee C, Yang P, et al. Variations in the NRAMP1 gene and susceptibility of tuberculosis in Taiwanese. Int J Tuberc Lung Dis. 2002;6:454-60 pubmed
    National Taiwan University Hospital, Taipei, Taiwan. To study the variations in the NRAMP1 gene using five genotypes (274C/T, 577-18G/A, A318V, D543N and 3' untranslated region [UTR]), and the susceptibility of tuberculosis and HIV ..
  7. Malik S, Abel L, Tooker H, Poon A, Simkin L, Girard M, et al. Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease. Proc Natl Acad Sci U S A. 2005;102:12183-8 pubmed
    ..design, we found allelic variants of the natural resistance-associated macrophage protein gene 1 (NRAMP1) (alias SLC11A1) significantly associated with tuberculosis disease in this pediatric patient population [P = 0...
  8. Kotze M, de Villiers J, Rooney R, Grobbelaar J, Mansvelt E, Bouwens C, et al. Analysis of the NRAMP1 gene implicated in iron transport: association with multiple sclerosis and age effects. Blood Cells Mol Dis. 2001;27:44-53 pubmed
    ..The functional Z-DNA forming repeat polymorphism of the natural resistance-associated macrophage protein-1 (NRAMP1) gene was analyzed in 104 patients diagnosed with MS and 522 Caucasian controls...
  9. Gazouli M, Atsaves V, Mantzaris G, Economou M, Nasioulas G, Evangelou K, et al. Role of functional polymorphisms of NRAMP1 gene for the development of Crohn's disease. Inflamm Bowel Dis. 2008;14:1323-30 pubmed publisher
    ..Natural resistance-associated macrophage protein 1 (NRAMP1) gene exerts many pleiotropic effects on macrophage functions...

More Information

Publications62

  1. Søborg C, Andersen A, Range N, Malenganisho W, Friis H, Magnussen P, et al. Influence of candidate susceptibility genes on tuberculosis in a high endemic region. Mol Immunol. 2007;44:2213-20 pubmed
    ..We investigated whether polymorphisms in the candidate genes encoding solute carrier 11a1 protein (SLC11A1 formerly NRAMP1), mannose-binding lectin (MBL2) and Vitamin D receptor (VDR) were associated with tuberculosis in ..
  2. Liu J, Fujiwara T, Buu N, Sanchez F, Cellier M, Paradis A, et al. Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene. Am J Hum Genet. 1995;56:845-53 pubmed
    ..by positional cloning and was designated "natural resistance-associated macrophage protein gene" (Nramp1), and the human homologue (NRAMP1) has recently been cloned...
  3. Nugraha J, Anggraini R. NRAMP1 polymorphism and susceptibility to lung tuberculosis in Surabaya, Indonesia. Southeast Asian J Trop Med Public Health. 2011;42:338-41 pubmed
    The aim of this study was to evaluate the role of three polymorphisms (D543N, TGTG deletion in 3' UTR, INT4 G/C) of NRAMP1 to susceptibility to lung tuberculosis (TB) disease...
  4. Comabella M, Altet L, Peris F, Villoslada P, Sanchez A, Montalban X. Genetic analysis of SLC11A1 polymorphisms in multiple sclerosis patients. Mult Scler. 2004;10:618-20 pubmed
    Solute carrier 11a1 (SLC11A1; formerly NRAMP1, where NRAMP stands for natural resistance-associated macrophage protein) is a proton/bivalent cation antiporter that localizes to late endosomes/lysosomes...
  5. Ma X, Dou S, Wright J, Reich R, Teeter L, El Sahly H, et al. 5' dinucleotide repeat polymorphism of NRAMP1 and susceptibility to tuberculosis among Caucasian patients in Houston, Texas. Int J Tuberc Lung Dis. 2002;6:818-23 pubmed
    ..To further explore the association between the polymorphisms of NRAMP1 and human susceptibility/resistance to tuberculosis (TB), specifically to determine whether the reported ..
  6. Leung K, Yip S, Wong W, Yiu L, Chan K, Lai W, et al. Sex- and age-dependent association of SLC11A1 polymorphisms with tuberculosis in Chinese: a case control study. BMC Infect Dis. 2007;7:19 pubmed
    Host genetic factors are important determinants in tuberculosis (TB). The SLC11A1 (or NRAMP1) gene has been studied extensively for genetic association with TB, but with inconsistent findings...
  7. Fitness J, Floyd S, Warndorff D, Sichali L, Malema S, Crampin A, et al. Large-scale candidate gene study of tuberculosis susceptibility in the Karonga district of northern Malawi. Am J Trop Med Hyg. 2004;71:341-9 pubmed
    ..studied CAAA insertion/deletion polymorphism in the 3'-untranslated region of solute carrier family 11, member 1 (SLC11A1, formerly NRAMP1) was associated with protection against TB in both HIV-positive (OR = 0.70, 95% CI = 0.49-0...
  8. Delgado J, Baena A, Thim S, Goldfeld A. Ethnic-specific genetic associations with pulmonary tuberculosis. J Infect Dis. 2002;186:1463-8 pubmed
    ..Here, polymorphisms in the natural resistance-associated macrophage protein 1 (NRAMP1), vitamin D receptor, tumor necrosis factor-alpha, interleukin (IL)-1, and IL-10 genes were evaluated in 358 ..
  9. Sahiratmadja E, Wieringa F, van Crevel R, de Visser A, Adnan I, Alisjahbana B, et al. Iron deficiency and NRAMP1 polymorphisms (INT4, D543N and 3'UTR) do not contribute to severity of anaemia in tuberculosis in the Indonesian population. Br J Nutr. 2007;98:684-90 pubmed
    ..The distribution of three polymorphisms in the natural resistance-associated macrophage protein gene (NRAMP1) including INT4, D543N and 3'UTR was examined for a possible association with susceptibility to TB...
  10. Kojima Y, Kinouchi Y, Takahashi S, Negoro K, Hiwatashi N, Shimosegawa T. Inflammatory bowel disease is associated with a novel promoter polymorphism of natural resistance-associated macrophage protein 1 (NRAMP1) gene. Tissue Antigens. 2001;58:379-84 pubmed
    ..Natural resistance-associated macrophage protein 1 (NRAMP1) gene regulates macrophage activation of antimicrobial activity and has many pleiotropic effects on macrophage ..
  11. Kishi F, Nobumoto M. Identification of natural resistance-associated macrophage protein in peripheral blood lymphocytes. Immunol Lett. 1995;47:93-6 pubmed
    Natural resistance-associated macrophage protein gene (Nramp) was isolated from the gene locus Lsh/Ity/Bcg, which regulates macrophage activation for antimicrobial activity against intracellular pathogens...
  12. Kotlowski R, Bernstein C, Silverberg M, Krause D. Population-based case-control study of alpha 1-antitrypsin and SLC11A1 in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis. 2008;14:1112-7 pubmed publisher
    ..detect alpha 1 antitrypsin M, S, and Z alleles and the C-to-T transition at the -237 nucleotide position of the SLC11A1 promoter...
  13. El Safi S, Kheir M, Bucheton B, Argiro L, Abel L, Dereure J, et al. Genes and environment in susceptibility to visceral leishmaniasis. C R Biol. 2006;329:863-70 pubmed
    ..Susceptibility to KA was shown to depend on a locus on chromosomes 22q12 and on NRAMP1 on chromosome 2q35; the data also suggested a third locus in the region 2q23-q24...
  14. Takahashi K, Satoh J, Kojima Y, Negoro K, Hirai M, Hinokio Y, et al. Promoter polymorphism of SLC11A1 (formerly NRAMP1) confers susceptibility to autoimmune type 1 diabetes mellitus in Japanese. Tissue Antigens. 2004;63:231-6 pubmed
    ..b>SLC11A1 (formerly NRAMP1), a divalent cation transporter, plays a crucial role in macrophage activation...
  15. Hoal E, Lewis L, Jamieson S, Tanzer F, Rossouw M, Victor T, et al. SLC11A1 (NRAMP1) but not SLC11A2 (NRAMP2) polymorphisms are associated with susceptibility to tuberculosis in a high-incidence community in South Africa. Int J Tuberc Lung Dis. 2004;8:1464-71 pubmed
    ..To investigate whether the reported association between SLC11A1 (also NRAMP1) polymorphisms and susceptibility to tuberculosis (TB) can be confirmed in a different population, ..
  16. Nishino M, Ikegami H, Fujisawa T, Kawaguchi Y, Kawabata Y, Shintani M, et al. Functional polymorphism in Z-DNA-forming motif of promoter of SLC11A1 gene and type 1 diabetes in Japanese subjects: association study and meta-analysis. Metabolism. 2005;54:628-33 pubmed
    ..promoter region of SLC11A1 (solute carrier family 11 member 1), formerly designated NRAMP1 (natural resistance associated macrophage protein 1), with type 1 diabetes was studied in a total of 244 Japanese subjects...
  17. Jin J, Sun L, Jiao W, Zhao S, Li H, Guan X, et al. SLC11A1 (Formerly NRAMP1) gene polymorphisms associated with pediatric tuberculosis in China. Clin Infect Dis. 2009;48:733-8 pubmed publisher
    ..Many factors, including host genetic factors, are involved in tuberculosis pathogenesis. The SLC11A1 gene (formerly NRAMP1) is a primary candidate for association with tuberculosis susceptibility...
  18. Yen J, Lin C, Tsai W, Ou T, Wu C, Hu C, et al. Natural resistance-associated macrophage protein 1 gene polymorphisms in rheumatoid arthritis. Immunol Lett. 2006;102:91-7 pubmed
    To investigate the association of natural resistance-associated macrophage protein 1 gene (NRAMP1) polymorphisms with rheumatoid arthritis (RA) in Taiwan...
  19. Zaahl M, Warnich L, Victor T, Kotze M. Association of functional polymorphisms of SLC11A1 with risk of esophageal cancer in the South African Colored population. Cancer Genet Cytogenet. 2005;159:48-52 pubmed
    ..The purpose of this study was to assess the likelihood that variation in the SLC11A1 gene contributes to EC susceptibility, possibly due to its role in inflammation and iron metabolism...
  20. Zhang W, Shao L, Weng X, Hu Z, Jin A, Chen S, et al. Variants of the natural resistance-associated macrophage protein 1 gene (NRAMP1) are associated with severe forms of pulmonary tuberculosis. Clin Infect Dis. 2005;40:1232-6 pubmed
    ..tuberculosis, studies that have assessed variants of the natural resistance-associated macrophage protein 1 gene (NRAMP1) and their association with tuberculosis in humans have yielded conflicting results...
  21. Taype C, Castro J, Accinelli R, Herrera Velit P, Shaw M, Espinoza J. Association between SLC11A1 polymorphisms and susceptibility to different clinical forms of tuberculosis in the Peruvian population. Infect Genet Evol. 2006;6:361-7 pubmed
    Polymorphism in SLC11A1 has been implicated in host susceptibility to tuberculosis. We have studied associations between INT4, D543N, and 3'UTR polymorphisms of SLC11A1 and different clinical forms of TB...
  22. Castellucci L, Jamieson S, Miller E, Menezes E, Oliveira J, Magalhaes A, et al. CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study. BMC Med Genet. 2010;11:10 pubmed publisher
    ..They lie 30-260 kb upstream of SLC11A1, a gene known primarily for its role in regulating macrophage activation, resistance to leishmaniasis, and wound ..
  23. Vejbaesya S, Chierakul N, Luangtrakool P, Sermduangprateep C. NRAMP1 and TNF-alpha polymorphisms and susceptibility to tuberculosis in Thais. Respirology. 2007;12:202-6 pubmed
    Polymorphisms in the natural resistance-associated macrophage protein gene 1 (NRAMP1) and tumour necrosis factor (TNF)-alpha gene have been found to be associated with susceptibility to tuberculosis in different populations...
  24. Blackwell J, Searle S, Mohamed H, White J. Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story. Immunol Lett. 2003;85:197-203 pubmed
    Solute carrier family 11 member a1 (Slc11a1), formerly known as Nramp1/Ity/Lsh/Bcg, is a proton/divalent cation antiporter that regulates susceptibility to infectious and autoimmune disease...
  25. Merza M, Farnia P, Anoosheh S, Varahram M, Kazampour M, Pajand O, et al. The NRAMPI, VDR and TNF-alpha gene polymorphisms in Iranian tuberculosis patients: the study on host susceptibility. Braz J Infect Dis. 2009;13:252-6 pubmed
    The natural resistance-associated macrophage protein (NRAMP1), Vitamin-D receptor (VDR) and Tumor necrosis factor (TNF-alpha) have been associated in susceptibility to tuberculosis, but the results have been inconsistent...
  26. Cellier M, Govoni G, Vidal S, Kwan T, Groulx N, Liu J, et al. Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression. J Exp Med. 1994;180:1741-52 pubmed
    ..A candidate gene for Bcg, designated natural resistance-associated macrophage protein (Nramp), has been isolated and shown to encode a novel macrophage-specific membrane protein, which is altered in ..
  27. Vidal S, Malo D, Vogan K, Skamene E, Gros P. Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell. 1993;73:469-85 pubmed
    ..RNA expression studies showed that one of them, designated Nramp, was expressed exclusively in macrophage populations from reticuloendothelial organs and in the macrophage line ..
  28. Meisner S, Mucklow S, Warner G, Sow S, Lienhardt C, Hill A. Association of NRAMP1 polymorphism with leprosy type but not susceptibility to leprosy per se in west Africans. Am J Trop Med Hyg. 2001;65:733-5 pubmed
    ..Murine studies have suggested a role for the natural resistance-associated macrophage protein 1 (Nramp1) gene, which can influence cellular immune responses to intracellular pathogens...
  29. Liu W, Cao W, Zhang C, Tian L, Wu X, Habbema J, et al. VDR and NRAMP1 gene polymorphisms in susceptibility to pulmonary tuberculosis among the Chinese Han population: a case-control study. Int J Tuberc Lung Dis. 2004;8:428-34 pubmed
    ..the potential role of vitamin D receptor (VDR) gene and natural-resistance-associated macrophage protein 1 (NRAMP1) gene polymorphisms in susceptibility to pulmonary tuberculosis (PTB) in the Chinese Han population...
  30. Gruenheid S, Pinner E, Desjardins M, Gros P. Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome. J Exp Med. 1997;185:717-30 pubmed
    The Nramp1 (natural-resistance-associated macrophage protein 1) locus (Bcg, Ity, Lsh) controls the innate resistance or susceptibility of mice to infection with a group of unrelated intracellular parasites which includes Salmonella, ..
  31. Abe T, Iinuma Y, Ando M, Yokoyama T, Yamamoto T, Nakashima K, et al. NRAMP1 polymorphisms, susceptibility and clinical features of tuberculosis. J Infect. 2003;46:215-20 pubmed
    To study whether NRAMP1 gene polymorphisms in a Japanese population affect susceptibility to tuberculosis and clinical features of tuberculosis...
  32. Ferreira F, Goulart L, Silva H, Goulart I. Susceptibility to leprosy may be conditioned by an interaction between the NRAMP1 promoter polymorphisms and the lepromin response. Int J Lepr Other Mycobact Dis. 2004;72:457-67 pubmed
    Controversial results have been achieved by attempting to associate the NRAMP1 gene with Mycobacterium leprae susceptibility as well as with the Mitsuda reaction, which represents a specific immune response to M. leprae...
  33. Atkinson P, Blackwell J, Barton C. Nramp1 locus encodes a 65 kDa interferon-gamma-inducible protein in murine macrophages. Biochem J. 1997;325 ( Pt 3):779-86 pubmed
    The murine Nramp1 (natural-resistance-associated macrophage protein) locus, formerly known as Ity/Lsh/Bcg, was isolated previously on the basis of chromosomal location, and as conferring natural resistance to infection against ..
  34. Sechi L, Gazouli M, Sieswerda L, Molicotti P, Ahmed N, Ikonomopoulos J, et al. Relationship between Crohn's disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients. World J Gastroenterol. 2006;12:7161-4 pubmed
    ..by examining the role of natural resistance-associated macrophage protein 1 (NRAMP1) gene polymorphisms (now SLC11A1) in Sardinian patients with CD and controls...
  35. Kim J, Lee S, Lee S, Sin C, Shim J, In K, et al. NRAMP1 genetic polymorphisms as a risk factor of tuberculous pleurisy. Int J Tuberc Lung Dis. 2003;7:370-5 pubmed
    Nrampl encoded by the NRAMP1 gene influences the phagolysosomal function of alveolar macrophage against Mycobacterium tuberculosis...
  36. Ouchi K, Suzuki Y, Shirakawa T, Kishi F. Polymorphism of SLC11A1 (formerly NRAMP1) gene confers susceptibility to Kawasaki disease. J Infect Dis. 2003;187:326-9 pubmed
    ..Results of this study showed that allele 1 of the 5' promoter (GT)n repeat in the SLC11A1 (formerly NRAMP1) gene, which endows the gene with a weak promoter activity, was highly represented in patients ..
  37. Zaahl M, Robson K, Warnich L, Kotze M. Expression of the SLC11A1 (NRAMP1) 5'-(GT)n repeat: opposite effect in the presence of -237C-->T. Blood Cells Mol Dis. 2004;33:45-50 pubmed
    ..of various autoimmune and infectious diseases with genetic variation in the solute carrier family 11 member 1 (SLC11A1) gene, formerly known as the natural resistance-associated macrophage protein 1 (NRAMP1) gene, is in accordance ..
  38. Runstadler J, Säilä H, Savolainen A, Leirisalo Repo M, Aho K, Tuomilehto Wolf E, et al. Association of SLC11A1 (NRAMP1) with persistent oligoarticular and polyarticular rheumatoid factor-negative juvenile idiopathic arthritis in Finnish patients: haplotype analysis in Finnish families. Arthritis Rheum. 2005;52:247-56 pubmed
    The SLC11A1 (formerly called NRAMP1) gene is important in natural resistance to a variety of intracellular infections mediated by macrophages and has been proposed as a candidate gene for autoimmune disease susceptibility...
  39. Bassuny W, Ihara K, Matsuura N, Ahmed S, Kohno H, Kuromaru R, et al. Association study of the NRAMP1 gene promoter polymorphism and early-onset type 1 diabetes. Immunogenetics. 2002;54:282-5 pubmed
    Natural resistance-associated macrophage protein 1 (NRAMP1) has an important role in regulating macrophage functions that affect innate resistance as well as immune responses...
  40. Ates O, Dalyan L, Hatemi G, Hamuryudan V, Topal Sarikaya A. Genetic susceptibility to Behçet's syndrome is associated with NRAMP1 (SLC11A1) polymorphism in Turkish patients. Rheumatol Int. 2009;29:787-91 pubmed publisher
    b>Natural resistance associated macrophage protein 1 (NRAMP1), also named as solute carrier family 11 member A1 gene (SLC11A1), has multiple pleiotropic effects on macrophage activation pathways such as up-regulation of the CXC chemokine KC,..
  41. Qu Y, Tang Y, Cao D, Wu F, Liu J, Lu G, et al. Genetic polymorphisms in alveolar macrophage response-related genes, and risk of silicosis and pulmonary tuberculosis in Chinese iron miners. Int J Hyg Environ Health. 2007;210:679-89 pubmed
    ..The aim of this study is to investigate the roles of AMs response-related genes TNF-alpha, iNOS, and NRAMP1 (SLC11A1) in susceptibility to silicosis and pulmonary tuberculosis (PTB), and to analyze the interaction of dust exposure ..
  42. Søborg C, Andersen A, Madsen H, Kok Jensen A, Skinhøj P, Garred P. Natural resistance-associated macrophage protein 1 polymorphisms are associated with microscopy-positive tuberculosis. J Infect Dis. 2002;186:517-21 pubmed
    The natural resistance-associated macrophage protein 1 (NRAMP1) is implicated in the pathophysiology of mycobacterial infections...
  43. Puzyrev V, Freidin M, Rudko A, Strelis A, Kolokolova O. [Polymorphisms of the candidate genes for genetic susceptibility to tuberculosis in the Slavic population of Siberia: a pilot study]. Mol Biol (Mosk). 2002;36:788-91 pubmed
    The 469 + 14 G/C (INT4), 1465 - 85 G/A, and C274T polymorphisms of NRAMP1 and the A/C polymorphism of IL12 3'-UTR were analyzed in ethnic Russians with (N = 58) or without (N = 127) tuberculosis (TB) from Tomsk...
  44. Blackwell J, Barton C, White J, Searle S, Baker A, Williams H, et al. Genomic organization and sequence of the human NRAMP gene: identification and mapping of a promoter region polymorphism. Mol Med. 1995;1:194-205 pubmed
    Murine Nramp is a candidate for the macrophage resistance gene Ity/Lsh/Bcg. Sequence analysis of human NRAMP was undertaken to determine its role in man...
  45. Ates O, Dalyan L, Musellim B, Hatemi G, Turker H, Ongen G, et al. NRAMP1 (SLC11A1) gene polymorphisms that correlate with autoimmune versus infectious disease susceptibility in tuberculosis and rheumatoid arthritis. Int J Immunogenet. 2009;36:15-9 pubmed publisher
    b>NRAMP1 gene has multiple pleiotropic effects on macrophage activation pathways...
  46. Canonne Hergaux F, Calafat J, Richer E, Cellier M, Grinstein S, Borregaard N, et al. Expression and subcellular localization of NRAMP1 in human neutrophil granules. Blood. 2002;100:268-75 pubmed
    Mutations at the Nramp1 gene cause susceptibility to infections with intracellular pathogens...
  47. Freidin M, Rudko A, Kolokolova O, Ondar E, Strelis A, Puzyrev V. [A comparative analysis of tuberculosis susceptibility genetic make-up in Tuvinians and Russians]. Mol Biol (Mosk). 2006;40:252-62 pubmed
    The results of the first Russian study of polymorphisms of tuberculosis (TB) susceptibility genes SLC11A1, VDR, IL12B, IL1B, IL1RN in Tuvinians from Tuva Republic and Russians from Tomsk city are presented...
  48. Niño Moreno P, Portales Pérez D, Hernández Castro B, Portales Cervantes L, Flores Meraz V, Baranda L, et al. P2X7 and NRAMP1/SLC11 A1 gene polymorphisms in Mexican mestizo patients with pulmonary tuberculosis. Clin Exp Immunol. 2007;148:469-77 pubmed
    ..b>NRAMP1/SLC11 A1 and P2X(7) genes have been linked to increased risk for tuberculosis in some African and Asiatic ..
  49. Bucheton B, Abel L, Kheir M, Mirgani A, El Safi S, Chevillard C, et al. Genetic control of visceral leishmaniasis in a Sudanese population: candidate gene testing indicates a linkage to the NRAMP1 region. Genes Immun. 2003;4:104-9 pubmed
    ..Studies have shown that the Nramp1 and H-2 genes are implicated in the control of Leishmania donovani infection in mice...
  50. Li H, Zhang T, Zhou Y, Huang Q, Huang J. SLC11A1 (formerly NRAMP1) gene polymorphisms and tuberculosis susceptibility: a meta-analysis. Int J Tuberc Lung Dis. 2006;10:3-12 pubmed
    ..We searched databases (MEDLINE, PUBMED and OVID) from January 1995 to December 2004 using 'gene' or 'SLC11A1' or 'NRAMP1', in combination with 'tuberculosis', performed a manual search of citations from relevant original ..
  51. Zaahl M, Winter T, Warnich L, Kotze M. The -237C-->T promoter polymorphism of the SLC11A1 gene is associated with a protective effect in relation to inflammatory bowel disease in the South African population. Int J Colorectal Dis. 2006;21:402-8 pubmed
    ..was to assess the likelihood that variation in the promoter region of the solute carrier family 11 member 1 gene (SLC11A1) contributes to inflammatory bowel disease (IBD) susceptibility in the South African population...
  52. Velez D, Hulme W, Myers J, Stryjewski M, Abbate E, Estevan R, et al. Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians. Int J Tuberc Lung Dis. 2009;13:1068-76 pubmed
    ..To test variants in solute carrier family 11A, member 1 (SLC11A1), for an association with TB...
  53. Marquet S, Lepage P, Hudson T, Musser J, Schurr E. Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35. Mamm Genome. 2000;11:755-62 pubmed
    Several lines of independent evidence suggest that human Natural Resistance Associated Macrophage Protein 1 gene (NRAMP1) is an important regulator of susceptibility to infectious diseases caused by certain intracellular pathogens...