SLC10A1

Summary

Gene Symbol: SLC10A1
Description: solute carrier family 10 member 1
Alias: NTCP, sodium/bile acid cotransporter, Na(+)/bile acid cotransporter, Na(+)/taurocholate transport protein, Na/taurocholate cotransporting polypeptide, cell growth-inhibiting gene 29 protein, growth-inhibiting protein 29, sodium/taurocholate cotransporter, sodium/taurocholate cotransporting polypeptide, solute carrier family 10 (sodium/bile acid cotransporter family), member 1, solute carrier family 10 (sodium/bile acid cotransporter), member 1
Species: human
Products:     SLC10A1

Top Publications

  1. Hagenbuch B, Meier P. Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter. J Clin Invest. 1994;93:1326-31 pubmed
    We have used a cDNA probe from a cloned rat liver Na+/taurocholate cotransporting polypeptide (Ntcp) to screen a human liver cDNA library...
  2. Yan H, Zhong G, Xu G, He W, Jing Z, Gao Z, et al. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. elife. 2012;1:e00049 pubmed publisher
    ..we revealed that the receptor-binding region of pre-S1 specifically interacts with sodium taurocholate cotransporting polypeptide (NTCP), a multiple transmembrane transporter predominantly expressed in the liver...
  3. Yan H, Peng B, Liu Y, Xu G, He W, Ren B, et al. Viral entry of hepatitis B and D viruses and bile salts transportation share common molecular determinants on sodium taurocholate cotransporting polypeptide. J Virol. 2014;88:3273-84 pubmed publisher
    The liver bile acids transporter sodium taurocholate cotransporting polypeptide (NTCP) is responsible for the majority of sodium-dependent bile salts uptake by hepatocytes...
  4. Yan J, Ai G, Zhang X, Xu H, Huang Z. Investigations of the total flavonoids extracted from flowers of Abelmoschus manihot (L.) Medic against α-naphthylisothiocyanate-induced cholestatic liver injury in rats. J Ethnopharmacol. 2015;172:202-13 pubmed publisher
    ..pump (BSEP), multidrug resistance-associated protein 2 (MRP2), and Na(+)-taurocholate cotransporting polypeptide (NTCP) were studied by western blot and reverse transcription-quantitative real-time polymerase chain reaction (RT-PCR) ..
  5. Sheraz M, Cheng J, Tang L, Chang J, Guo J. Cellular DNA topoisomerases are required for the synthesis of hepatitis B virus covalently closed circular DNA. J Virol. 2019;: pubmed publisher
    ..also disrupted cccDNA synthesis during de novo HBV infection of HepG2 cells expressing sodium taurocholate cotransporting polypeptide (NTCP)...
  6. Baghdasaryan A, Fuchs C, Österreicher C, Lemberger U, Halilbasic E, Påhlman I, et al. Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis. J Hepatol. 2016;64:674-81 pubmed publisher
    ..significantly reduced bile flow and biliary BA output, which correlated with reduced Bsep transcription, while Ntcp and Cyp7a1 were induced...
  7. Qi Y, Gao Z, Xu G, Peng B, Liu C, Yan H, et al. DNA Polymerase ? Is a Key Cellular Factor for the Formation of Covalently Closed Circular DNA of Hepatitis B Virus. PLoS Pathog. 2016;12:e1005893 pubmed publisher
    Hepatitis B virus (HBV) infection of hepatocytes begins by binding to its cellular receptor sodium taurocholate cotransporting polypeptide (NTCP), followed by the internalization of viral nucleocapsid into the cytoplasm...
  8. Ananthanarayanan M, Li Y, Surapureddi S, Balasubramaniyan N, Ahn J, Goldstein J, et al. Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis. Am J Physiol Gastrointest Liver Physiol. 2011;300:G771-81 pubmed publisher
    ..of bile salt export pump (BSEP), multidrug resistance associated protein 2 (MRP2), and sodium taurocholate cotransporting polypeptide (NTCP) genes by FXR and glucocorticoid receptor (GR)...
  9. Ferdek P, Jakubowska M, Gerasimenko J, Gerasimenko O, Petersen O. Bile acids induce necrosis in pancreatic stellate cells dependent on calcium entry and sodium-driven bile uptake. J Physiol. 2016;594:6147-6164 pubmed publisher
    ..signals on extracellular Na+ and the presence of sodium-taurocholate cotransporting polypeptide (NTCP) indicate a Na+ -dependent bile acid uptake mechanism in stellate cells...

More Information

Publications138 found, 100 shown here

  1. Zhu R, Sun Y, Hou Y, Fan J, Chen G, Li T. Pectin penta-oligogalacturonide reduces cholesterol accumulation by promoting bile acid biosynthesis and excretion in high-cholesterol-fed mice. Chem Biol Interact. 2017;272:153-159 pubmed publisher
    ..bile salt export pump (BSEP) expression but didn't affect the sodium/taurocholate co-transporting polypeptide (NTCP) expression...
  2. Tanaka T, Okuyama Dobashi K, Murakami S, Chen W, Okamoto T, Ueda K, et al. Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation. Antiviral Res. 2016;133:156-64 pubmed publisher
    ..HepG2 cells expressing human sodium taurocholate cotransporting polypeptide (HepG2/NTCP cells) were infected with HBV in the presence of FIT-039...
  3. He W, Ren B, Mao F, Jing Z, Li Y, Liu Y, et al. Hepatitis D Virus Infection of Mice Expressing Human Sodium Taurocholate Co-transporting Polypeptide. PLoS Pathog. 2015;11:e1004840 pubmed publisher
    ..Liver sodium taurocholate co-transporting polypeptide (NTCP) was recently identified as a common entry receptor for HDV and HBV in cell cultures...
  4. Radreau P, Porcherot M, Ramière C, Mouzannar K, Lotteau V, Andre P. Reciprocal regulation of farnesoid X receptor ? activity and hepatitis B virus replication in differentiated HepaRG cells and primary human hepatocytes. FASEB J. 2016;30:3146-54 pubmed publisher
    ..HBV enters hepatocytes by binding to sodium taurocholate cotransporting polypeptide (NTCP), the genome of which contains 2 active farnesoid X receptor (FXR) ? response elements ..
  5. Bodeman C, Dzierlenga A, Tally C, Mulligan R, Lake A, Cherrington N, et al. Differential regulation of hepatic organic cation transporter 1, organic anion-transporting polypeptide 1a4, bile-salt export pump, and multidrug resistance-associated protein 2 transporter expression in lymphocyte-deficient mice associates with inte. J Pharmacol Exp Ther. 2013;347:136-44 pubmed publisher
    ..Bsep); multidrug resistance-associated proteins (Mrp) 2 and 3; and sodium-taurocholate cotransporting polypeptide (Ntcp)...
  6. Winer B, Shirvani Dastgerdi E, Bram Y, Sellau J, Low B, Johnson H, et al. Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection. Sci Transl Med. 2018;10: pubmed publisher
    ..for HDV expressing the functional receptor for HBV and HDV, the human sodium taurocholate cotransporting peptide NTCP. Both HBV and HDV entered hepatocytes in these mice in a glycoprotein-dependent manner, but one or more postentry ..
  7. Sommerfeld A, Reinehr R, Haussinger D. Tauroursodeoxycholate Protects Rat Hepatocytes from Bile Acid-Induced Apoptosis via β1-Integrin- and Protein Kinase A-Dependent Mechanisms. Cell Physiol Biochem. 2015;36:866-83 pubmed publisher
    ..In line with this, the β1-integrin siRNA knockdown in sodium taurocholate cotransporting polypeptide (Ntcp)-transfected HepG2 cells abolished the protective effect of TUDC against GCDC-induced ..
  8. Yu H, Jiang H, Cheng S, Hu Z, Ren J, Chen J. AGK2, A SIRT2 Inhibitor, Inhibits Hepatitis B Virus Replication In Vitro And In Vivo. Int J Med Sci. 2018;15:1356-1364 pubmed publisher
    ..The HepG2-NTCP cells expressing the sodium taurocholate cotransporting polypeptide (NTCP) receptor are susceptible to HBV infection...
  9. Ni Y, Urban S. Hepatitis B Virus Infection of HepaRG Cells, HepaRG-hNTCP Cells, and Primary Human Hepatocytes. Methods Mol Biol. 2017;1540:15-25 pubmed
    ..factors, and transporter proteins like the HBV-specific receptor, sodium taurocholate co-transporting polypeptide (NTCP). HepaRG cells have also been shown to express key molecules of the innate immune system...
  10. Schupp A, Trilling M, Rattay S, Le Trilling V, Haselow K, Stindt J, et al. Bile Acids Act as Soluble Host Restriction Factors Limiting Cytomegalovirus Replication in Hepatocytes. J Virol. 2016;90:6686-6698 pubmed publisher
    ..activity required active import of bile acids via the sodium-taurocholate-cotransporting polypeptide (NTCP) and was consistently observed in hepatocytes but not in fibroblasts...
  11. Abbas Z, Abbas M. Management of hepatitis delta: Need for novel therapeutic options. World J Gastroenterol. 2015;21:9461-5 pubmed publisher
    ..Hepatitis B and D viruses exploit the human sodium taurocholate co-transporting polypeptide (NTCP), a receptor, for their entry into hepatocytes...
  12. Slopianka M, Herrmann A, Pavkovic M, Ellinger Ziegelbauer H, Ernst R, Mally A, et al. Quantitative targeted bile acid profiling as new markers for DILI in a model of methapyrilene-induced liver injury in rats. Toxicology. 2017;386:1-10 pubmed publisher
    ..profiling revealed downregulation of genes involved in BA synthesis (AMACR, BAAT, ACOX2) and hepatocellular uptake (NTCP, OATs), and upregulation for efflux transporters (MRP2, MRP4), suggesting an adaptive hepatocellular protection ..
  13. Jiao L, Gan Schreier H, Tuma Kellner S, Stremmel W, Chamulitrat W. Sensitization to autoimmune hepatitis in group VIA calcium-independent phospholipase A2-null mice led to duodenal villous atrophy with apoptosis, goblet cell hyperplasia and leaked bile acids. Biochim Biophys Acta. 2015;1852:1646-57 pubmed publisher
    ..significant decrease in hepatic and biliary bile acids, and this was associated with suppression of hepatic Cyp7A1, Ntcp and ABCB11/Bsep and upregulation of intestinal FXR/FGF15 mRNA expression...
  14. Li X, Zhong K, Guo Z, Zhong D, Chen X. Fasiglifam (TAK-875) Inhibits Hepatobiliary Transporters: A Possible Factor Contributing to Fasiglifam-Induced Liver Injury. Drug Metab Dispos. 2015;43:1751-9 pubmed publisher
    ..TAK-875 also inhibited the major bile acid uptake transporter Na(+)/taurocholate cotransporting polypeptide (Ntcp), which transports d₈-taurocholic acid into rat hepatocytes, with an IC₅₀ value of 10.9 μM...
  15. Duan X, Li S, Holmes J, Tu Z, Li Y, Cai D, et al. MicroRNA 130a Regulates both Hepatitis C Virus and Hepatitis B Virus Replication through a Central Metabolic Pathway. J Virol. 2018;92: pubmed publisher
    ..1 cells, and HCV JFH1-infected primary human hepatocytes (PHHs) and HBV replication in HepAD38 cells, HBV-infected NTCP-Huh7.5...
  16. Huang H, Tao M, Hung T, Chen J, Lin Z, Huang C. (-)-Epigallocatechin-3-gallate inhibits entry of hepatitis B virus into hepatocytes. Antiviral Res. 2014;111:100-11 pubmed publisher
    ..DMSO-differentiated HuS-E/2 cells expressed sodium taurocholate cotransporting polypeptide (NTCP), which is a receptor for HBV...
  17. Harada K, Nishitsuji H, Ujino S, Shimotohno K. Identification of KX2-391 as an inhibitor of HBV transcription by a recombinant HBV-based screening assay. Antiviral Res. 2017;144:138-146 pubmed publisher
    ..Treatment of sodium taurocholate cotransporting polypeptide (NTCP) transduced-HepG2 (HepG2-NTCP) or primary human hepatocytes with KX2-391 suppressed HBV ..
  18. Ko C, Chakraborty A, Chou W, Hasreiter J, Wettengel J, Stadler D, et al. Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels. J Hepatol. 2018;69:1231-1241 pubmed publisher
    ..We selected a highly permissive HepG2-NTCP-K7 cell clone engineered to express sodium taurocholate co-transporting polypeptide (NTCP) that supports the full ..
  19. Pozzo L, Vornoli A, Coppola I, Croce C, Giorgetti L, Gervasi P, et al. Effect of HFD/STZ on expression of genes involved in lipid, cholesterol and glucose metabolism in rats. Life Sci. 2016;166:149-156 pubmed publisher
    ..gene expression of FXR-dependent SHP (a key gene for feedback inhibition of CYP7A1 and CYP8B1) and of bile acids (NTCP, OATP1A1, BSEP) and cholesterol (ABCA1) transporters was found...
  20. Feng X, Du X, Chen S, Yue D, Cheng Y, Zhang L, et al. Swertianlarin, isolated from Swertia mussotii Franch, increases detoxification enzymes and efflux transporters expression in rats. Int J Clin Exp Pathol. 2015;8:184-95 pubmed
    ..g. Cyp7a1 and Cyp3a), membrane influx and efflux transporters (e.g. Ntcp and Mrp3), nuclear receptors (e.g. Pxr and Fxr/Shp) and transcriptional factors (e.g...
  21. Wang L, Collins C, Kelly E, Chu X, Ray A, Salphati L, et al. Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics. Drug Metab Dispos. 2016;44:1752-1758 pubmed
    ..multidrug resistance-associated protein (MRP)2, MRP3, MRP4, sodium taurocholate-cotransporting polypeptide (NTCP), organic anion-transporting polypeptides (OATP)1B1, 1B3, 2B1, organic cation transporter 1 (OCT1), and P-..
  22. Kim Y, Fang S, Byun S, Seok S, Kemper B, Kemper J. Farnesoid X receptor-induced lysine-specific histone demethylase reduces hepatic bile acid levels and protects the liver against bile acid toxicity. Hepatology. 2015;62:220-31 pubmed publisher
    ..farnesoid X receptor, is recruited to the BA synthetic genes Cyp7a1 and Cyp8b1 and the BA uptake transporter gene Ntcp, and removes a gene-activation marker, trimethylated histone H3 lysine-4, leading to gene repression...
  23. Nio Y, Akahori Y, Okamura H, Watashi K, Wakita T, Hijikata M. Inhibitory effect of fasiglifam on hepatitis B virus infections through suppression of the sodium taurocholate cotransporting polypeptide. Biochem Biophys Res Commun. 2018;501:820-825 pubmed publisher
    ..Fasiglifam showed an inhibitory effect on sodium taurocholate cotransporting polypeptide (NTCP) in human and rat hepatocytes...
  24. Li Y, Xia Y, Cheng X, Kleiner D, Hewitt S, Sproch J, et al. Hepatitis B Surface Antigen Activates Unfolded Protein Response in Forming Ground Glass Hepatocytes of Chronic Hepatitis B. Viruses. 2019;11: pubmed publisher
    ..The mechanism by which HBV activates UPR has not been fully defined. To investigate this, HepG2-NTCP cells and primary human hepatocytes (PHHs) were either infected with HBV or transduced with adenoviral vectors ..
  25. Liu Q, Somiya M, Iijima M, Tatematsu K, Kuroda S. A hepatitis B virus-derived human hepatic cell-specific heparin-binding peptide: identification and application to a drug delivery system. Biomater Sci. 2018;7:322-335 pubmed publisher
    ..e., the sodium taurocholate co-transporting polypeptide (NTCP)-binding site, with myristoylated pre-S1(2-47)) and the low pH-dependent fusogenic domain (pre-S1(9-24)) are ..
  26. Cangelosi Q, Means S, Ho H. A multi-scale spatial model of hepatitis-B viral dynamics. PLoS ONE. 2017;12:e0188209 pubmed publisher
    ..g., the sodium-taurocholate cotransporting polypeptide or NTCP), or immune system activity...
  27. Li W, Urban S. Entry of hepatitis B and hepatitis D virus into hepatocytes: Basic insights and clinical implications. J Hepatol. 2016;64:S32-S40 pubmed publisher
    ..2) The suitability of NTCP complemented cell culture systems for high throughput screening approaches will facilitate identification of novel ..
  28. Li R, Niosi M, Johnson N, Tess D, Kimoto E, Lin J, et al. A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects. Drug Metab Dispos. 2018;46:346-356 pubmed publisher
    ..With further validation and refinement, we conclude that this approach may serve to predict human liver exposure and complement other methods involving tissue biopsy and imaging. ..
  29. Cornelius C, Schöneweis K, Georgi F, Weber M, Niederberger V, Zieglmayer P, et al. Immunotherapy With the PreS-based Grass Pollen Allergy Vaccine BM32 Induces Antibody Responses Protecting Against Hepatitis B Infection. EBioMedicine. 2016;11:58-67 pubmed publisher
    ..IgG antibodies from BM32-vaccinated but not of HBV-infected individuals recognized the sequence motif implicated in NTCP (sodium-taurocholate co-transporting polypeptide)-receptor interaction of the hepatitis B virus and inhibited HBV ..
  30. Iwamoto M, Watashi K, Tsukuda S, Aly H, Fukasawa M, Fujimoto A, et al. Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP. Biochem Biophys Res Commun. 2014;443:808-13 pubmed publisher
    ..Recently, the sodium taurocholate cotransporting polypeptide (NTCP) membrane transporter was reported as an HBV entry receptor...
  31. Carrington R, Staffurth J, Warren S, Partridge M, Hurt C, Spezi E, et al. The effect of dose escalation on gastric toxicity when treating lower oesophageal tumours: a radiobiological investigation. Radiat Oncol. 2015;10:236 pubmed publisher
    ..Dose-volume metrics and estimates of normal tissue complication probability (NTCP) were compared...
  32. Alterio D, Gerardi M, Cella L, Spoto R, Zurlo V, Sabbatini A, et al. Radiation-induced acute dysphagia : Prospective observational study on 42 head and neck cancer patients. Strahlenther Onkol. 2017;193:971-981 pubmed publisher
    ..bootstrapping) was applied to select model order and parameters for normal tissue complication probability (NTCP) modelling. A strong multiple correlation between dosimetric parameters was found...
  33. Ulvestad M, Nordell P, Asplund A, Rehnström M, Jacobsson S, Holmgren G, et al. Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells. Biochem Pharmacol. 2013;86:691-702 pubmed publisher
    ..With regard to transporters, in hESC-Hep and hiPSC-Hep, pronounced NTCP activity (17% and 29% of 4 h hphep, respectively) and moderate BSEP activity (6% and 8% of 4 h hphep, respectively) ..
  34. Srivastava S, Cheng C, Das I. The dosimetric and radiobiological impact of calculation grid size on head and neck IMRT. Pract Radiat Oncol. 2017;7:209-217 pubmed publisher
    ..grid size on dose distribution for tumor control probability (TCP) and normal tissue complication probability (NTCP) is investigated for head and neck (H&N) intensity modulated radiation therapy (IMRT)...
  35. Linguissi L, Gwom L, Nkenfou C, Bates M, Petersen E, Zumla A, et al. Health systems in the Republic of Congo: challenges and opportunities for implementing tuberculosis and HIV collaborative service, research, and training activities. Int J Infect Dis. 2017;56:62-67 pubmed publisher
    ..and HIV in the Republic of Congo are reviewed, and the gaps and bottlenecks that the National TB Control Program (NTCP) faces are discussed...
  36. Casillas R, Tabernero D, Gregori J, Belmonte I, Cortese M, Gonzalez C, et al. Analysis of hepatitis B virus preS1 variability and prevalence of the rs2296651 polymorphism in a Spanish population. World J Gastroenterol. 2018;24:680-692 pubmed publisher
    ..hepatitis B virus (HBV) preS1 region that interacts with sodium-taurocholate cotransporting polypeptide (hereafter, NTCP-interacting domain) and the prevalence of the rs2296651 polymorphism (S267F, NTCP variant) in a Spanish population...
  37. Bátai Konczos A, Veres Z, Szabo M, Ioja E, László G, Török G, et al. Comparative study of CYP2B1/2 induction and the transport of bilirubin and taurocholate in rat hepatocyte-mono- and hepatocyte-Kupffer cell co-cultures. J Pharmacol Toxicol Methods. 2016;82:1-8 pubmed publisher
    ..Immuno-labelling of sodium-dependent taurocholate transporter (Ntcp) revealed increased expression of the transporter in the presence of KCs...
  38. Austin A, Douglass M, Nguyen G, Penfold S. A radiobiological Markov simulation tool for aiding decision making in proton therapy referral. Phys Med. 2017;44:72-82 pubmed publisher
    ..effect is estimated using the tumour control probability (TCP), normal tissue complication probability (NTCP) and second primary cancer induction probability (SPCIP)...
  39. Li J, Tong S. From DCPD to NTCP: the long journey towards identifying a functional hepatitis B virus receptor. Clin Mol Hepatol. 2015;21:193-9 pubmed publisher
    ..Recently, sodium taurocholate cotransporting polypeptide (NTCP) has been identified as a binding partner for the N-terminus of HBV large envelope ..
  40. Wan Z, Lin X, Li T, Zhou A, Yang M, Hu D, et al. Genetic variant in CXCL13 gene is associated with susceptibility to intrauterine infection of hepatitis B virus. Sci Rep. 2016;6:26465 pubmed publisher
    ..We conducted this study to investigate the associations between 10 genetic variants in 9 genes (SLC10A1, HLA-DP, HLA-C, CXCR5, CXCL13, TLR3, TLR4, TLR9 and UBE2L3) of mothers and their neonates and HBV intrauterine ..
  41. Bell K, Heitfeld M, Licht N, Rube C, Dzierma Y. Influence of daily imaging on plan quality and normal tissue toxicity for prostate cancer radiotherapy. Radiat Oncol. 2017;12:7 pubmed publisher
    ..considered with regard to their influence on dosimetric plan quality and normal tissue complication probability (NTCP). This study is based on treatment plans of 50 prostate patients...
  42. Testa A, Dall Angelo S, Mingarelli M, Augello A, Schweiger L, Welch A, et al. Design, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transporters. Bioorg Med Chem. 2017;25:963-976 pubmed publisher
    ..In addition, the lead compound, LCATD (4c), was tested as a substrate of other liver uptake transporters OATP1B3, NTCP and efflux transporter BSEP to evaluate its specificity of liver transport...
  43. Schneider U, Ernst M, Hartmann M. The dose-response relationship for cardiovascular disease is not necessarily linear. Radiat Oncol. 2017;12:74 pubmed publisher
    ..The relative seriality model was then used to predict NTCP of cardiovascular disease for a homogenously irradiated heart ("a little to a lot")...
  44. Thomas L, Kantz S, Hung A, Monaco D, Gaertner F, Essler M, et al. 68Ga-PSMA-PET/CT imaging of localized primary prostate cancer patients for intensity modulated radiation therapy treatment planning with integrated boost. Eur J Nucl Med Mol Imaging. 2018;45:1170-1178 pubmed publisher
    ..Tumor control probability (TCP) and normal tissue complication probability (NTCP) was calculated for all plan variations...
  45. Slijepcevic D, Roscam Abbing R, Katafuchi T, Blank A, Donkers J, Van Hoppe S, et al. Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice. Hepatology. 2017;66:1631-1643 pubmed publisher
    The Na+ -taurocholate cotransporting polypeptide (NTCP/SLC10A1) is believed to be pivotal for hepatic uptake of conjugated bile acids...
  46. Mayati A, Moreau A, Denizot C, Stieger B, Parmentier Y, Fardel O. β2-adrenergic receptor-mediated in vitro regulation of human hepatic drug transporter expression by epinephrine. Eur J Pharm Sci. 2017;106:302-312 pubmed publisher
    ..epinephrine for 24h repressed mRNA expression of various transporters, such as the sinusoidal influx transporters NTCP, OATP1B1, OATP2B1, OAT2, OAT7 and OCT1 and the efflux transporters MRP2, MRP3 and BSEP, whereas it induced that of ..
  47. Moon S, Yoon M, Chung M, Chung W, Kim D. Comparison of the extent of hippocampal sparing according to the tilt of a patient's head during WBRT using linear accelerator-based IMRT and VMAT. Phys Med. 2016;32:657-63 pubmed publisher
    ..DVH), we calculated and compared the effective uniform dose (EUD), normal tissue complication probability (NTCP) of the OAR and the mean and the maximum doses of hippocampus...
  48. Chiesa C, Mira M, Maccauro M, Spreafico C, Romito R, Morosi C, et al. Radioembolization of hepatocarcinoma with (90)Y glass microspheres: development of an individualized treatment planning strategy based on dosimetry and radiobiology. Eur J Nucl Med Mol Imaging. 2015;42:1718-1738 pubmed publisher
    ..Tumour control probability (TCP) and normal tissue complication probability (NTCP) were derived...
  49. Sumida I, Yamaguchi H, Das I, Kizaki H, Aboshi K, Tsujii M, et al. Evaluation of the radiobiological gamma index with motion interplay in tangential IMRT breast treatment. J Radiat Res. 2016;57:691-701 pubmed
    ..calculated from the PGI using the tumor control probability (TCP) and the normal tissue complication probability (NTCP)...
  50. Yan R, Zhang Y, Cai D, Liu Y, Cuconati A, Guo H. Spinoculation Enhances HBV Infection in NTCP-Reconstituted Hepatocytes. PLoS ONE. 2015;10:e0129889 pubmed publisher
    ..Recently, sodium taurocholate cotransporting polypeptide (NTCP) has been identified as the HBV receptor...
  51. Schonhoff C, Yamazaki A, Hohenester S, Webster C, Bouscarel B, Anwer M. PKC{epsilon}-dependent and -independent effects of taurolithocholate on PI3K/PKB pathway and taurocholate uptake in HuH-NTCP cell line. Am J Physiol Gastrointest Liver Physiol. 2009;297:G1259-67 pubmed publisher
    ..activation of PKCepsilon in HuH7 cells stably transfected with human Na(+)-dependent TC-cotransporting polypeptide (NTCP) (HuH-NTCP cells)...
  52. Yoshimura T, Kinoshita R, Onodera S, Toramatsu C, Suzuki R, Ito Y, et al. NTCP modeling analysis of acute hematologic toxicity in whole pelvic radiation therapy for gynecologic malignancies - A dosimetric comparison of IMRT and spot-scanning proton therapy (SSPT). Phys Med. 2016;32:1095-102 pubmed publisher
    ..The normal tissue complication probability (NTCP) of the risk of HT3+ was used as an in silico surrogate marker in this analysis...
  53. Geyer J, Wilke T, Petzinger E. The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. Naunyn Schmiedebergs Arch Pharmacol. 2006;372:413-31 pubmed
    ..e. the Na(+)/taurocholate cotransporting polypeptide (NTCP; SLC10A1) and the apical sodium-dependent bile acid transporter (ASBT; SLC10A2)...
  54. Fukahori M, Matsufuji N, Himukai T, Kanematsu N, Mizuno H, Fukumura A, et al. Estimation of late rectal normal tissue complication probability parameters in carbon ion therapy for prostate cancer. Radiother Oncol. 2016;118:136-40 pubmed publisher
    The aim of this study was to estimate normal tissue complication probability (NTCP) parameters for late rectal complications after carbon ion radiotherapy (C-ion RT) for prostate cancer...
  55. Jaber A, Khan A, Sulaiman S, Ahmad N. Role of socio-demographical factors on tuberculosis outcome in Yemen. Int J Mycobacteriol. 2016;5 Suppl 1:S20 pubmed publisher
    ..TB considers as one of the main health problems; it ranks as the fourth in the priority of the public health issue (NTCP, 2010). The study was conducted to evaluate the Socio-Demographical variables on tuberculosis treatment outcome...
  56. Yao H, Xu Y, Yin L, Tao X, Xu L, Qi Y, et al. Dioscin Protects ANIT-Induced Intrahepatic Cholestasis Through Regulating Transporters, Apoptosis and Oxidative Stress. Front Pharmacol. 2017;8:116 pubmed publisher
    ..In mechanism study, dioscin not only significantly regulated the protein levels of Ntcp, OAT1, OCT1, Bsep and Mrp2 to accelerate bile acids excretion, but also regulated the expression levels of Bak, Bcl-..
  57. Bijsmans I, Bouwmeester R, Geyer J, Faber K, van de Graaf S. Homo- and hetero-dimeric architecture of the human liver Na?-dependent taurocholate co-transporting protein. Biochem J. 2012;441:1007-15 pubmed publisher
    The NTCP (Na?-taurocholate co-transporting protein)/SLC10A [solute carrier family 10 (Nav/bile acid co-transporter family)] 1 is tightly controlled to ensure hepatic bile salt uptake while preventing toxic bile salt accumulation...
  58. Schonhoff C, Park S, Webster C, Anwer M. p38 MAPK ? and ? isoforms differentially regulate plasma membrane localization of MRP2. Am J Physiol Gastrointest Liver Physiol. 2016;310:G999-G1005 pubmed publisher
    ..mice and in a hepatoma cell line (HuH7) that overexpresses sodium-taurocholate cotransporting polypeptide (NTCP) (HuH-NTCP)...
  59. Yu D, Zhang H, Lionarons D, Boyer J, Cai S. Na+-taurocholate cotransporting polypeptide (NTCP/SLC10A1) ortholog in the marine skate Leucoraja erinacea is not a physiological bile salt transporter. Am J Physiol Regul Integr Comp Physiol. 2017;312:R477-R484 pubmed publisher
    The Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1) is a hepatocyte-specific solute carrier, which plays an important role in maintaining bile salt homeostasis in mammals...
  60. Guo Y, Xu X, Zhang Q, Li C, Deng Y, Jiang P, et al. The inhibition of hepatic bile acids transporters Ntcp and Bsep is involved in the pathogenesis of isoniazid/rifampicin-induced hepatotoxicity. Toxicol Mech Methods. 2015;25:382-7 pubmed publisher
    ..The present study investigates whether sodium taurocholate cotransporting polypeptide (NTCP/Ntcp; SLC10A1) and bile salt export pump (BSEP/Bsep; ABCB11) are involved in the anti-..
  61. Ko C, Park W, Park S, Kim S, Windisch M, Ryu W. The FDA-approved drug irbesartan inhibits HBV-infection in HepG2 cells stably expressing sodium taurocholate co-transporting polypeptide. Antivir Ther. 2015;20:835-42 pubmed publisher
    ..for antiviral targets, but the recent seminal discovery of sodium taurocholate co-transporting polypeptide (NTCP) as the cellular receptor for HBV entry opened up many avenues of investigation, making HBV entry amenable to ..
  62. Fleckenstein J, Kremp K, Kremp S, Palm J, Rübe C. IMRT and 3D conformal radiotherapy with or without elective nodal irradiation in locally advanced NSCLC: A direct comparison of PET-based treatment planning. Strahlenther Onkol. 2016;192:75-82 pubmed publisher
    ..dose (PD), tumor control probability (TCP), conformal indices (CI), and normal tissue complication probabilities (NTCP) were analyzed...
  63. Faught A, Miyasaka Y, Kadoya N, Castillo R, Castillo E, Vinogradskiy Y, et al. Evaluating the Toxicity Reduction With Computed Tomographic Ventilation Functional Avoidance Radiation Therapy. Int J Radiat Oncol Biol Phys. 2017;99:325-333 pubmed publisher
    ..Maximum likelihood methods were used to generate normal tissue complication probability (NTCP) models predicting grade 2 or higher (2+) and grade 3+ pneumonitis as a function of dose (V5 Gy, V10 Gy, V20 Gy, ..
  64. Cheraghi S, Nikoofar A, Bakhshandeh M, Khoei S, Farahani S, Abdollahi H, et al. Normal tissue complication probability modeling of radiation-induced sensorineural hearing loss after head-and-neck radiation therapy. Int J Radiat Biol. 2017;:1-7 pubmed publisher
    The aim of this study was to generate the dose-response curves by six normal tissue complication probability (NTCP) models and ranking the models for prediction of radiation induced sensorineural hearing loss (SNHL) caused by head and ..
  65. Avanzo M, Trovo M, Stancanello J, Jena R, Roncadin M, Toffoli G, et al. Hypofractionation of partial breast irradiation using radiobiological models. Phys Med. 2015;31:1022-1028 pubmed publisher
    ..Risk for RIF in hypofractionated treatment was predicted by calculating NTCP from DVHs of group A rescaled to fractions and dose of novel regimens...
  66. Mavroidis P, Pearlstein K, Dooley J, Sun J, Saripalli S, Das S, et al. Fitting NTCP models to bladder doses and acute urinary symptoms during post-prostatectomy radiotherapy. Radiat Oncol. 2018;13:17 pubmed publisher
    To estimate the radiobiological parameters of three popular normal tissue complication probability (NTCP) models, which describe the dose-response relations of bladder regarding different acute urinary symptoms during post-prostatectomy ..
  67. Hilgendorf C, Ahlin G, Seithel A, Artursson P, Ungell A, Karlsson J. Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines. Drug Metab Dispos. 2007;35:1333-40 pubmed
    ..expressed in the intestine included HPT1, PEPT1, BCRP, MRP2, and MDR1, whereas, in the liver, OCT1, MRP2, OATP-C, NTCP and BSEP were the main transporters...
  68. Ekins S, Clark A, Wright S. Making Transporter Models for Drug-Drug Interaction Prediction Mobile. Drug Metab Dispos. 2015;43:1642-5 pubmed publisher
    ..We used recently published transporter data sets (MATE1, MATE2K, OCT2, OCTN2, ASBT, and NTCP) to build preliminary models in a commercial tool and in open software that can deliver the model in a mobile app...
  69. Donkers J, Zehnder B, van Westen G, Kwakkenbos M, Ijzerman A, Oude Elferink R, et al. Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP. Sci Rep. 2017;7:15307 pubmed publisher
    The sodium taurocholate co-transporting polypeptide (NTCP, SLC10A1) is the main hepatic transporter of conjugated bile acids, and the entry receptor for hepatitis B virus (HBV) and hepatitis delta virus (HDV)...
  70. Shen H, Nelson D, Oliveira R, Zhang Y, McNaney C, Gu X, et al. Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys. Drug Metab Dispos. 2018;46:178-188 pubmed publisher
    ..OAT1, OAT3, OAT2 (HVA), and OAT4 (PDA), but not OCT2, MATE1, MATE2K, OATP1B1, OATP1B3, and sodium taurocholate cotransporting polypeptide. Collectively, these findings suggest that PDA and HVA might serve as blood-based endogenous ..
  71. Bi Y, Mathialagan S, Tylaska L, Fu M, Keefer J, Vildhede A, et al. Organic Anion Transporter 2 Mediates Hepatic Uptake of Tolbutamide, a CYP2C9 Probe Drug. J Pharmacol Exp Ther. 2018;364:390-398 pubmed publisher
    ..Our results provide first-line evidence for the role of OAT2-mediated hepatic uptake in the pharmacokinetics of tolbutamide, and imply the need for additional clinical studies in this direction. ..
  72. Moteabbed M, Yock T, Depauw N, Madden T, Kooy H, Paganetti H. Impact of Spot Size and Beam-Shaping Devices on the Treatment Plan Quality for Pencil Beam Scanning Proton Therapy. Int J Radiat Oncol Biol Phys. 2016;95:190-8 pubmed publisher
    ..indices, dose-volume histogram parameters, equivalent uniform dose (EUD), normal tissue complication probability (NTCP), and integral dose were quantified and compared with the respective PSPT plans...
  73. Stam B, Peulen H, Rossi M, Belderbos J, Sonke J. Validation of automatic segmentation of ribs for NTCP modeling. Radiother Oncol. 2016;118:528-34 pubmed publisher
    ..the accuracy of automatic rib segmentation in the context of normal tissue complication probability modeling (NTCP)...
  74. Aguilar Olivos N, Carrillo Córdova D, Oria Hernández J, Sánchez Valle V, Ponciano Rodríguez G, Ramírez Jaramillo M, et al. The nuclear receptor FXR, but not LXR, up-regulates bile acid transporter expression in non-alcoholic fatty liver disease. Ann Hepatol. 2015;14:487-93 pubmed
    ..SHP) and liver X alpha (LXRα) receptors- and BA transporters -sodium+/taurocholate cotransporting polypeptide (NTCP) and bile salt export pump (BSEP)- in liver biopsy samples of patients with simple steatosis (SS) and NASH...
  75. Schonhoff C, Ramasamy U, Anwer M. Nitric oxide-mediated inhibition of taurocholate uptake involves S-nitrosylation of NTCP. Am J Physiol Gastrointest Liver Physiol. 2011;300:G364-70 pubmed publisher
    The sodium-taurocholate (TC) cotransporting polypeptide (NTCP) facilitates bile formation by mediating sinusoidal Na(+)-TC cotransport...
  76. Blanchard P, Wong A, Gunn G, Garden A, Mohamed A, Rosenthal D, et al. Toward a model-based patient selection strategy for proton therapy: External validation of photon-derived normal tissue complication probability models in a head and neck proton therapy cohort. Radiother Oncol. 2016;121:381-386 pubmed publisher
    To externally validate head and neck cancer (HNC) photon-derived normal tissue complication probability (NTCP) models in patients treated with proton beam therapy (PBT)...
  77. King R, Osman S, Fairmichael C, Irvine D, Lyons C, Ravi A, et al. Efficacy of a rectal spacer with prostate SABR-first UK experience. Br J Radiol. 2018;91:20170672 pubmed publisher
    ..patients, investigating practicality, dosimetric impact, normal tissue complication probability (NTCP) and early toxicity...
  78. Patel P, Weerasekera N, Hitchins M, Boyd C, Johnston D, Williamson C. Semi quantitative expression analysis of MDR3, FIC1, BSEP, OATP-A, OATP-C,OATP-D, OATP-E and NTCP gene transcripts in 1st and 3rd trimester human placenta. Placenta. 2003;24:39-44 pubmed
    ..Transcripts of the hepatic sinusoidal bile acid transporter, NTCP, were not detected in placenta.
  79. Ramasamy U, Anwer M, Schonhoff C. Cysteine 96 of Ntcp is responsible for NO-mediated inhibition of taurocholate uptake. Am J Physiol Gastrointest Liver Physiol. 2013;305:G513-9 pubmed publisher
    The Na(+) taurocholate (TC) cotransporting polypeptide Ntcp/NTCP mediates TC uptake across the sinusoidal membrane of hepatocytes...
  80. Santana Machado T, Poitevin S, Paul P, McKay N, Jourde Chiche N, Legris T, et al. Indoxyl Sulfate Upregulates Liver P-Glycoprotein Expression and Activity through Aryl Hydrocarbon Receptor Signaling. J Am Soc Nephrol. 2018;29:906-918 pubmed publisher
    ..receptor, could change the expression of the following liver transporters involved in drug clearance: SLC10A1, SLC22A1, SLC22A7, SLC47A1, SLCO1B1, SLCO1B3, SLCO2B1, ABCB1,..
  81. Miura T, Kimura N, Yamada T, Shimizu T, Nanashima N, Yamana D, et al. Sustained repression and translocation of Ntcp and expression of Mrp4 for cholestasis after rat 90% partial hepatectomy. J Hepatol. 2011;55:407-14 pubmed publisher
    ..To clarify the mechanism of persistent cholestasis after massive hepatectomy, the relationship between such cholestasis and the expression and localization of organic anion transporters for bile acids was examined in a rat model...
  82. Okuyama Dobashi K, Kasai H, Tanaka T, Yamashita A, Yasumoto J, Chen W, et al. Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide. Sci Rep. 2015;5:17047 pubmed publisher
    b>Sodium taurocholate cotransporting polypeptide (NTCP) has been reported as a functional receptor for hepatitis B virus (HBV) infection...
  83. Nakabori T, Hikita H, Murai K, Nozaki Y, Kai Y, Makino Y, et al. Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver. Sci Rep. 2016;6:27782 pubmed publisher
    b>Sodium taurocholate cotransporting polypeptide (NTCP) is a recently discovered hepatitis B virus (HBV) receptor...
  84. Kierkels R, Wopken K, Visser R, Korevaar E, van der Schaaf A, Bijl H, et al. Multivariable normal tissue complication probability model-based treatment plan optimization for grade 2-4 dysphagia and tube feeding dependence in head and neck radiotherapy. Radiother Oncol. 2016;121:374-380 pubmed publisher
    ..We aimed to explore OFs based on multivariable normal tissue complication probability (NTCP) models for grade 2-4 dysphagia (DYS) and tube feeding dependence (TFD)...
  85. Febvre James M, Bruyère A, Le Vee M, Fardel O. The JAK1/2 Inhibitor Ruxolitinib Reverses Interleukin-6-Mediated Suppression of Drug-Detoxifying Proteins in Cultured Human Hepatocytes. Drug Metab Dispos. 2018;46:131-140 pubmed publisher
    ..was found to fully inhibit IL-6-mediated repression of P450 (CYP1A2, CYP2B6, and CYP3A4) and transporter (NTCP, OATP1B1, and OCT1) mRNA levels in primary human hepatocytes and differentiated hepatoma HepaRG cells...
  86. Borlak J, Klutcka T. Expression of basolateral and canalicular transporters in rat liver and cultures of primary hepatocytes. Xenobiotica. 2004;34:935-47 pubmed
    ..Strikingly, expression of the basolateral membrane transporter ntcp and oatpl and 2 were dramatically reduced, the level being < 10 and < 5%, respectively, of those found in ..
  87. Eloranta J, Jung D, Kullak Ublick G. The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechani. Mol Endocrinol. 2006;20:65-79 pubmed
    Na+-taurocholate cotransporting polypeptide (NTCP) is the major bile acid uptake system in human hepatocytes...
  88. Li J, Zong L, Sureau C, Barker L, Wands J, Tong S. Unusual Features of Sodium Taurocholate Cotransporting Polypeptide as a Hepatitis B Virus Receptor. J Virol. 2016;90:8302-13 pubmed publisher
    ..Identification of sodium taurocholate cotransporting polypeptide (NTCP) as an HBV receptor enabled ccHBV infection of NTCP reconstituted HepG2 cells, although ..
  89. Ezzikouri S, Chihab H, Elhabazi A, Wakrim L, Benjelloun S. Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status. BMC Infect Dis. 2017;17:99 pubmed publisher
    The sodium taurocholate co-transporting polypeptide, encoded by SLC10A1, was identified as a functional receptor for hepatitis B virus (HBV)...
  90. Xu L, Sheng T, Liu X, Zhang T, Wang Z, Han H. Analyzing the hepatoprotective effect of the Swertia cincta Burkillextract against ANIT-induced cholestasis in rats by modulating the expression of transporters and metabolic enzymes. J Ethnopharmacol. 2017;209:91-99 pubmed publisher
    ..Western blot and qRT-PCR analyses showed that ESC upregulated the protein and mRNA expression of Fxr, Ntcp, Bsep, Cyp7a1, Mrp2, and Mdr2...
  91. Wang L, Rubadue K, Alberts J, Bedwell D, Ruterbories K. Development of a rapid and sensitive multiple reaction monitoring proteomic approach for quantification of transporters in human liver tissue. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1061-1062:356-363 pubmed publisher
    ..method for rapid and simultaneous quantification of 12 hepatic transporters (BCRP, BSEP, MATE1, MRP2, MRP3, MRP4, NTCP, OATP1B1, 1B3, 2B1, OCT1, and P-gp) was developed. Using a high LC flow rate (1...
  92. Stieger B. The role of the sodium-taurocholate cotransporting polypeptide (NTCP) and of the bile salt export pump (BSEP) in physiology and pathophysiology of bile formation. Handb Exp Pharmacol. 2011;:205-59 pubmed publisher
    ..Uptake of bile salts into hepatocytes occurs largely in a sodium-dependent manner by the sodium taurocholate cotransporting polypeptide NTCP. The transport properties of NTCP have been extensively characterized...