SLBP

Summary

Gene Symbol: SLBP
Description: stem-loop binding protein
Alias: HBP, histone RNA hairpin-binding protein, hairpin binding protein, histone, histone binding protein, histone stem-loop binding protein, stem-loop (histone) binding protein
Species: human
Products:     SLBP

Top Publications

  1. Dominski Z, Erkmann J, Yang X, Sanchez R, Marzluff W. A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing. Genes Dev. 2002;16:58-71 pubmed
    The stem-loop binding protein (SLBP) is the posttranscriptional regulator of histone mRNA in metazoan cells. SLBP binds histone pre-mRNAs and facilitates 3'-end processing by promoting stable association of U7 snRNP with the pre-mRNA...
  2. Zheng L, Dominski Z, Yang X, Elms P, Raska C, Borchers C, et al. Phosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle-regulated factor required for regulation of histone mRNA processing, at the end of S phase. Mol Cell Biol. 2003;23:1590-601 pubmed
    ..The protein that binds the 3' end of histone mRNA, stem-loop binding protein (SLBP), is required for histone pre-mRNA processing and is involved in multiple aspects of histone mRNA metabolism...
  3. Narita T, Yung T, Yamamoto J, Tsuboi Y, Tanabe H, Tanaka K, et al. NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs. Mol Cell. 2007;26:349-65 pubmed
    ..of replication-dependent histone mRNAs, most likely through association with the histone stem-loop binding protein (SLBP). Strikingly, absence of NELF and CBC causes aberrant production of polyadenylated histone mRNAs...
  4. Wang Z, Whitfield M, Ingledue T, Dominski Z, Marzluff W. The protein that binds the 3' end of histone mRNA: a novel RNA-binding protein required for histone pre-mRNA processing. Genes Dev. 1996;10:3028-40 pubmed
    ..The stem-loop binding protein (SLBP) that binds the 3' end of histone mRNA is a candidate for the factor that participates in most, if not all, of the ..
  5. Sullivan K, Mullen T, Marzluff W, Wagner E. Knockdown of SLBP results in nuclear retention of histone mRNA. RNA. 2009;15:459-72 pubmed publisher
    ..The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cytoplasm, where SLBP ..
  6. Krishnan N, Lam T, Fritz A, Rempinski D, O Loughlin K, Minderman H, et al. The prolyl isomerase Pin1 targets stem-loop binding protein (SLBP) to dissociate the SLBP-histone mRNA complex linking histone mRNA decay with SLBP ubiquitination. Mol Cell Biol. 2012;32:4306-22 pubmed publisher
    ..This sequence is the binding site for stem-loop binding protein (SLBP), which helps to recruit components of the RNA degradation machinery to the histone mRNA 3' end...
  7. Whitfield M, Zheng L, Baldwin A, Ohta T, Hurt M, Marzluff W. Stem-loop binding protein, the protein that binds the 3' end of histone mRNA, is cell cycle regulated by both translational and posttranslational mechanisms. Mol Cell Biol. 2000;20:4188-98 pubmed
    ..A 31-kDa stem-loop binding protein (SLBP) binds the 3' end of histone mRNA...
  8. Kaygun H, Marzluff W. Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1. Nat Struct Mol Biol. 2005;12:794-800 pubmed
    ..Here we show that regulated degradation of histone mRNAs requires Upf1, a key regulator of the nonsense-mediated decay pathway, and ATR, a key regulator of the DNA damage checkpoint pathway activated during replication stress...
  9. Choe J, Kim K, Park S, Lee Y, Song O, Kim M, et al. Rapid degradation of replication-dependent histone mRNAs largely occurs on mRNAs bound by nuclear cap-binding proteins 80 and 20. Nucleic Acids Res. 2013;41:1307-18 pubmed publisher
    ..Here, using a yeast two-hybrid screening system, we identify a stem-loop binding protein (SLBP) that binds to a stem-loop structure at the 3'-end of the replication-dependent histone mRNA as a CT initiation ..

More Information

Publications116 found, 100 shown here

  1. Dominski Z, Yang X, Kaygun H, Dadlez M, Marzluff W. A 3' exonuclease that specifically interacts with the 3' end of histone mRNA. Mol Cell. 2003;12:295-305 pubmed
    ..Previous studies have suggested that the stem-loop binding protein (SLBP) is the only protein binding this region...
  2. Zhao X, McKillop Smith S, Muller B. The human histone gene expression regulator HBP/SLBP is required for histone and DNA synthesis, cell cycle progression and cell proliferation in mitotic cells. J Cell Sci. 2004;117:6043-51 pubmed
    ..In metazoans, the histone RNA binding protein HBP/SLBP is involved in post-transcriptional control of histone gene expression...
  3. Wagner E, Berkow A, Marzluff W. Expression of an RNAi-resistant SLBP restores proper S-phase progression. Biochem Soc Trans. 2005;33:471-3 pubmed
    ..are unique in that they lack a 3'-polyadenylated tail, but instead end in a conserved stem loop that is bound by SLBP (stem-loop binding protein). SLBP is required for efficient histone mRNA synthesis and translation...
  4. Martin F, Schaller A, Eglite S, Schumperli D, Muller B. The gene for histone RNA hairpin binding protein is located on human chromosome 4 and encodes a novel type of RNA binding protein. EMBO J. 1997;16:769-78 pubmed
    ..These features prompted us to select for HBP-encoding human cDNAs by RNA-mediated three-hybrid selection in Saccharomyces cerevesiae...
  5. Dominski Z, Zheng L, Sanchez R, Marzluff W. Stem-loop binding protein facilitates 3'-end formation by stabilizing U7 snRNP binding to histone pre-mRNA. Mol Cell Biol. 1999;19:3561-70 pubmed
    ..The cleavage reaction requires at least two trans-acting factors: the stem-loop binding protein (SLBP), which binds the stem-loop sequence, and the U7 snRNP that interacts with a sequence downstream from the cleavage ..
  6. Cakmakci N, Lerner R, Wagner E, Zheng L, Marzluff W. SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein. Mol Cell Biol. 2008;28:1182-94 pubmed
    ..The 3' end of histone mRNA is required for histone mRNA translation, as is the stem-loop binding protein (SLBP), which binds the 3' end of histone mRNA...
  7. Mullen T, Marzluff W. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. Genes Dev. 2008;22:50-65 pubmed publisher
    ..Degradation of histone mRNAs requires the stem-loop sequence, which binds the stem-loop-binding protein (SLBP), active translation of the histone mRNA, and the location of the stem-loop close to the termination codon...
  8. Bansal N, Zhang M, Bhaskar A, Itotia P, Lee E, Shlyakhtenko L, et al. Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1. Biochemistry. 2013;52:520-36 pubmed publisher
    The SLIP1-SLBP complex activates translation of replication-dependent histone mRNAs. In this report, we describe how the activity of the SLIP1-SLBP complex is modulated by phosphorylation and oligomerization...
  9. Ishino K, Kudo M, Peng W, Kure S, Kawahara K, Teduka K, et al. 2-Deoxy-d-glucose increases GFAT1 phosphorylation resulting in endoplasmic reticulum-related apoptosis via disruption of protein N-glycosylation in pancreatic cancer cells. Biochem Biophys Res Commun. 2018;501:668-673 pubmed publisher
    ..glutamine: fructose 6-phosphate aminotransferase 1 (GFAT1), which belongs to the hexosamine biosynthesis pathway (HBP) that produces uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) to maintain glycoprotein, was validated by ..
  10. Hwang J, Park J, Nam M, Cho H, Han I. Glucosamine enhances body weight gain and reduces insulin response in mice fed chow diet but mitigates obesity, insulin resistance and impaired glucose tolerance in mice high-fat diet. Metabolism. 2015;64:368-79 pubmed publisher
    ..Therefore, the current data support the integrative function of the HBP reflecting the nutrient status of lipids or glucose and further implicate the importance of the pathway in insulin ..
  11. Cui Y, Xue R, Xi He -, Ming Zhao -, Yu X, Liu L, et al. Cholinergic drugs ameliorate endothelial dysfunction by decreasing O-GlcNAcylation via M3 AChR-AMPK-ER stress signaling. Life Sci. 2019;222:1-12 pubmed publisher
    ..O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins via increasing hexosamine biosynthetic pathway (HBP) flux. However, the changes and regulation of the O-GlcNAc levels induced by obesity are unclear...
  12. Hjelm A, Söderström B, Vikström D, Jong W, Luirink J, de Gier J. Autotransporter-based antigen display in bacterial ghosts. Appl Environ Microbiol. 2015;81:726-35 pubmed publisher
    ..Recently, we have engineered the Escherichia coli autotransporter hemoglobin protease (Hbp) into a platform for the efficient surface display of heterologous proteins in Gram-negative bacteria, HbpD...
  13. Afrifa Anane E, Agyemang C, Codjoe S, Ogedegbe G, de Graft Aikins A. The association of physical activity, body mass index and the blood pressure levels among urban poor youth in Accra, Ghana. BMC Public Health. 2015;15:269 pubmed publisher
    Globally, there is an increasing prevalence of high blood pressure (HBP) among adults and youth...
  14. Kim G, Cao L, Reece E, Zhao Z. Impact of protein O-GlcNAcylation on neural tube malformation in diabetic embryopathy. Sci Rep. 2017;7:11107 pubmed publisher
    ..Hyperglycemia augments a branch pathway in glycolysis, the hexosamine biosynthetic pathway (HBP), to increase uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc)...
  15. Walejko J, Kim S, Goel R, Handberg E, Richards E, Pepine C, et al. Gut microbiota and serum metabolite differences in African Americans and White Americans with high blood pressure. Int J Cardiol. 2018;271:336-339 pubmed publisher
    ..This concept was tested in a pilot study. Subjects with high (HBP, >140/80 mm Hg) and normal (NBP, <120/80 mm Hg) blood pressure (BP) provided stool and blood samples ..
  16. Zhang W, Bouchard G, Yu A, Shafiq M, Jamali M, Shrager J, et al. GFPT2-Expressing Cancer-Associated Fibroblasts Mediate Metabolic Reprogramming in Human Lung Adenocarcinoma. Cancer Res. 2018;78:3445-3457 pubmed publisher
    ..aminotransferase 2 (GFAT2), a rate-limiting enzyme of the hexosamine biosynthesis pathway (HBP), which is responsible for glycosylation...
  17. Harris R, Apolzan J. Hexosamine biosynthetic pathway activity in leptin resistant sucrose-drinking rats. Physiol Behav. 2015;138:208-18 pubmed publisher
    ..Increased availability of glucose and fructose can stimulate the hexosamine biosynthetic pathway (HBP) which O-GlcNAc-modifies proteins. This has the potential to change protein bioactivity...
  18. Thapar R. Roles of Prolyl Isomerases in RNA-Mediated Gene Expression. Biomolecules. 2015;5:974-99 pubmed publisher
    ..Pin1 also binds several RNA binding proteins such as AUF1, KSRP, HuR, and SLBP that regulate mRNA decay by remodeling mRNP complexes...
  19. Efimova E, Takahashi S, Shamsi N, Wu D, Labay E, Ulanovskaya O, et al. Linking Cancer Metabolism to DNA Repair and Accelerated Senescence. Mol Cancer Res. 2016;14:173-84 pubmed publisher
    ..pathways common to glycolysis and glutaminolysis uncovered opposing effects of the hexosamine biosynthetic pathway (HBP) and tricarboxylic acid (TCA) cycle...
  20. Krause M, Frederiksen H, Sundberg K, Jørgensen F, Jensen L, Nørgaard P, et al. Maternal exposure to UV filters: associations with maternal thyroid hormones, IGF-I/IGFBP3 and birth outcomes. Endocr Connect. 2018;7:334-346 pubmed publisher
    ..of the chemical UV filters benzophenone-1 (BP-1) and benzophenone-3 (BP-3) in urine and 4-hydroxy-benzophenone (4-HBP) in serum were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
  21. Annamalai G, Suresh K. [6]-Shogaol attenuates inflammation, cell proliferation via modulate NF-?B and AP-1 oncogenic signaling in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis. Biomed Pharmacother. 2018;98:484-490 pubmed publisher
    ..efficacy of [6]-SHO in 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis (HBP) has not been fully elucidated, so far...
  22. Wong S, Wu L, Robker R, Thompson J, McDowall M. Hyperglycaemia and lipid differentially impair mouse oocyte developmental competence. Reprod Fertil Dev. 2015;27:583-92 pubmed publisher
    ..Previously, we demonstrated that, separately, upregulation of the hexosamine biosynthetic pathway (HBP; under hyperglycaemic conditions) and endoplasmic reticulum (ER) stress (due to hyperlipidaemia) pathways reduce ..
  23. Zambrano A, García Carpizo V, Villamuera R, Aranda A. Thyroid hormone increases bulk histones expression by enhancing translational efficiency. Mol Endocrinol. 2015;29:68-75 pubmed publisher
    ..at their 3' terminus, but instead possess a stem-loop motif, the binding site for the stem-loop binding protein (SLBP), which regulates mRNA processing, stability, and relocation to polysomes...
  24. Lankoande M, Bonkoungou P, Ouandaogo S, Dayamba M, Ouédraogo A, Veyckmans F, et al. Incidence and outcome of severe ante-partum hemorrhage at the Teaching Hospital Yalgado Ouédraogo in Burkina Faso. BMC Emerg Med. 2017;17:17 pubmed publisher
    ..9%) was the most common cause of fetal death (p = 0.005) and was associated with High Blood Pressure (HBP) and pre-eclampsia. APH is a complication associated with significant maternal and fetal morbidity and mortality.
  25. Karatuna O, Celebi B, Can S, Akyar I, Kilic S. The use of Matrix-assisted laser desorption ionization-time of flight mass spectrometry in the identification of Francisella tularensis. Bosn J Basic Med Sci. 2016;16:132-8 pubmed publisher
    ..In the case of HBP, there is a pressing need for rapid, accurate and reliable identification...
  26. Takeyama N, Vidhyarkorn S, Chung D, Siripongsakun S, Kim H, Lu D, et al. Does hepatobiliary phase sequence qualitatively outperform unenhanced T1-weighted imaging in assessment of the ablation margin 24 hours after thermal ablation of hepatocellular carcinomas?. Abdom Radiol (NY). 2016;41:1942-55 pubmed publisher
    To retrospectively determine whether hepatobiliary phase (HBP) sequence outperforms unenhanced T1-weighted imaging (uT1wI) in distinguishing the ablation margin (AM) from hepatocellular carcinoma (HCC) 24 h after thermoablation...
  27. Ferrer C, Sodi V, Reginato M. O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling. J Mol Biol. 2016;428:3282-3294 pubmed publisher
    The hexosamine biosynthetic pathway (HBP) is highly dependent on multiple metabolic nutrients including glucose, glutamine, and acetyl-CoA...
  28. Andreadis E, Papademetriou V, Geladari C, Kolyvas G, Angelopoulos E, Aronis K. Home, automated office, and conventional office blood pressure as predictors of cardiovascular risk. J Am Soc Hypertens. 2017;11:165-170.e2 pubmed publisher
    ..Home blood pressure (HBP) has also been accepted as a valuable method in the prediction of CV disease...
  29. Bonito V, Smits A, Goor O, Ippel B, Driessen Mol A, Münker T, et al. Modulation of macrophage phenotype and protein secretion via heparin-IL-4 functionalized supramolecular elastomers. Acta Biomater. 2018;71:247-260 pubmed publisher
    ..chain extended polycaprolactone (CE-UPy-PCL) was mixed with a UPy-modified heparin binding peptide (UPy-HBP) to allow for immobilization of heparin, and further functionalization with IL-4 via its heparin binding domain...
  30. Yang X, Purdy M, Marzluff W, Dominski Z. Characterization of 3'hExo, a 3' exonuclease specifically interacting with the 3' end of histone mRNA. J Biol Chem. 2006;281:30447-54 pubmed
    ..3'hExo removes 3' overhangs of small interfering RNAs, whereas the double-stranded region is resistant to the enzymatic activity. ..
  31. Maurya M, Sarkar B, Avecilla F, Correia I. Vanadium(iv and v) complexes of pyrazolone based ligands: Synthesis, structural characterization and catalytic applications. Dalton Trans. 2016;45:17343-17364 pubmed
    The ONO donor ligands obtained from the condensation of 4-benzoyl-3-methyl-1-phenyl-2-pyrazoline-5-one (Hbp) with benzoylhydrazide (H2bp-bhz I), furoylhydrazide (H2bp-fah II), nicotinoylhydrazide (H2bp-..
  32. Qin C, Sleaby R, Davidoff A, Bell J, De Blasio M, Delbridge L, et al. Insights into the role of maladaptive hexosamine biosynthesis and O-GlcNAcylation in development of diabetic cardiac complications. Pharmacol Res. 2017;116:45-56 pubmed publisher
    ..It has been shown that the maladaptive nutrient-sensing hexosamine biosynthesis pathway (HBP) contributes to diabetic complications in many non-cardiac tissues...
  33. Yang Y, Song J, Wang S, Liu F, Zhang Y, Shang X, et al. Genetic variations in sterol regulatory element binding protein cleavage-activating protein (SCAP) are associated with blood pressure in overweight/obese Chinese children. PLoS ONE. 2017;12:e0177973 pubmed publisher
    ..A case-control study on 702 high blood pressure (HBP) children and 1319 controls was conducted to explore the correlation between single nucleotide polymorphism markers ..
  34. Aik W, Lin M, Tan D, Tripathy A, Marzluff W, Dominski Z, et al. The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3'-end processing. PLoS ONE. 2017;12:e0186034 pubmed publisher
    ..They have a 3' stem loop and histone downstream element (HDE) that are recognized by stem-loop binding protein (SLBP) and U7 snRNP, respectively...
  35. Schonberger R, Nwozuzu A, Zafar J, Chen E, Kigwana S, Monteiro M, et al. Elevated preoperative blood pressures in adult surgical patients are highly predictive of elevated home blood pressures. J Am Soc Hypertens. 2018;12:303-310 pubmed publisher
    ..The relationship between BP measured during this assessment and home blood pressure (HBP), a better indicator of hypertension, is unknown...
  36. Teng A, Lustgarten D, Vijayaraman P, Tung R, Shivkumar K, Wagner G, et al. Usefulness of His Bundle Pacing to Achieve Electrical Resynchronization in Patients With Complete Left Bundle Branch Block and the Relation Between Native QRS Axis, Duration, and Normalization. Am J Cardiol. 2016;118:527-34 pubmed publisher
    His Bundle pacing (HBP) restores electrical synchronization in left bundle branch block (LBBB); however, the underlying mechanisms are poorly understood...
  37. Li L, Feng C, Yang J. Tensile and compressive behaviors of prestrained single-layer black phosphorus: a molecular dynamics study. Nanoscale. 2017;9:3609-3619 pubmed publisher
    The effect of prestrain on tensile and compressive behaviors of single-layer black phosphorus (SLBP) in both armchair and zigzag directions is investigated by using molecular dynamics simulations...
  38. Curcio S, García Espinosa V, Castro J, Peluso G, Marotta M, Arana M, et al. High Blood Pressure States in Children, Adolescents, and Young Adults Associate Accelerated Vascular Aging, with a Higher Impact in Females' Arterial Properties. Pediatr Cardiol. 2017;38:840-852 pubmed publisher
    The aims of the study were to determine (1) whether the presence of High blood pressure (HBP) states in the youth associate a steeper rate of age-related change in arterial geometrical and wall properties with respect to subjects with no ..
  39. Lee H, Lee C, Kim J, Park Y, Lee J, Kim K. Use of hepatobiliary phase images in Gd-EOB-DTPA-enhanced MRI of breast cancer hepatic metastasis to predict response to chemotherapy. Clin Imaging. 2017;43:127-131 pubmed publisher
    ..8%) vs. 4/18 (22.2%)], and it was associated with a better response [p=0.048]. HBP analysis may be useful to predict the response to chemotherapy and survival.
  40. Lehmann L, Jebessa Z, Kreusser M, Horsch A, He T, Kronlage M, et al. A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway. Nat Med. 2017;: pubmed publisher
    ..encodes a nuclear orphan receptor, and decreased NR4A1-dependent activation of the hexosamine biosynthetic pathway (HBP)...
  41. Huang W, Wassie M, Ajijola O. Permanent His Bundle Pacing for Cardiac Resynchronization. Curr Treat Options Cardiovasc Med. 2018;20:23 pubmed publisher
    His bundle pacing (HBP) has been shown to be a feasible, beneficial, and safe way to achieve cardiac resynchronization therapy (CRT) with recruitment of the heart's physiological conduction system...
  42. McCombie W, Martin Gallardo A, Gocayne J, Fitzgerald M, Dubnick M, Kelley J, et al. Expressed genes, Alu repeats and polymorphisms in cosmids sequenced from chromosome 4p16.3. Nat Genet. 1992;1:348-53 pubmed
    ..The structure of one of the new genes, hda1-1, has been determined by characterizing cDNAs from a placental library. This gene is expressed in a variety of tissues and may encode a novel housekeeping gene. ..
  43. Koh J, Chung Y, Nahm J, Kim H, Kim K, Park Y, et al. Intrahepatic mass-forming cholangiocarcinoma: prognostic value of preoperative gadoxetic acid-enhanced MRI. Eur Radiol. 2016;26:407-16 pubmed publisher
    ..The signal intensity of the IMCCs on hepatobiliary phase (HBP) MRI was qualitatively analyzed by two radiologists, and categorized into intermediate or hypointense groups...
  44. Su L, Xu L, Wu S, Huang W. Pacing and sensing optimization of permanent His-bundle pacing in cardiac resynchronization therapy/implantable cardioverter defibrillators patients: value of integrated bipolar configuration. Europace. 2016;18:1399-405 pubmed publisher
    The clinical implementation of His-bundle pacing (HBP) has been limited by concern over higher capture thresholds (CTs) and lower R-wave amplitudes (RWAs), when compared with right ventricular (RV) pacing...
  45. Min J, Kim Y, Choi S, Jeong W, Lee W, Ha S, et al. Differentiation between cholangiocarcinoma and hepatocellular carcinoma with target sign on diffusion-weighted imaging and hepatobiliary phase gadoxetic acid-enhanced MR imaging: Classification tree analysis applying capsule and septum. Eur J Radiol. 2017;92:1-10 pubmed publisher
    ..tree analysis (CTA) for discrimination of hepatocellular carcinoma (HCC) with target sign on hepatobiliary phase (HBP) and/or diffusion-weighted image (DWI) from intrahepatic cholangiocarcinoma (ICC)...
  46. Djakbarova U, Marzluff W, Koseoglu M. Translation regulation and proteasome mediated degradation cooperate to keep stem-loop binding protein low in G1-phase. J Cell Biochem. 2014;115:523-30 pubmed publisher
    ..A major regulatory mechanism is S-phase restriction of Stem-loop binding protein (SLBP) which binds to the 3' end of histone mRNA and participates in multiple steps of histone mRNA metabolism, including ..
  47. Michalski D, Steiniger M. In vivo characterization of the Drosophila mRNA 3' end processing core cleavage complex. RNA. 2015;21:1404-18 pubmed publisher
    ..for histone mRNA 3' end processing similar to RNAi-depletion of histone-specific 3' end processing factors FLASH, SLBP, and U7 snRNA...
  48. Masuda Y, Takahashi H, Sato S, Tomomori Sato C, Saraf A, Washburn M, et al. TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin. Nat Commun. 2015;6:7299 pubmed publisher
    ..Our results suggest that TRIM29 functions as a scaffold protein to assemble DNA repair proteins into chromatin followed by efficient activation of DDR. ..
  49. Tessier D, Meneilly G, Moleski L, Trottier L, Lanthier L. Influence of Blood Pressure and Other Clinical Variables on Long-Term Mortality in a Cohort of Elderly Subjects with Type 2 Diabetes. Can J Diabetes. 2016;40:12-6 pubmed publisher
    Diabetes mellitus and high blood pressure (HBP) are commonly associated conditions in the elderly population. An effect of treatments, biologic and anthropometric variables on long-term mortality is unknown in this population...
  50. Zhou F, Huo J, Liu Y, Liu H, Liu G, Chen Y, et al. Elevated glucose levels impair the WNT/β-catenin pathway via the activation of the hexosamine biosynthesis pathway in endometrial cancer. J Steroid Biochem Mol Biol. 2016;159:19-25 pubmed publisher
    ..studies have suggested that elevated concentrations of glucose can drive the hexosamine biosynthesis pathway (HBP) flux, thereby enhancing the O-GlcNAc modification of proteins...
  51. Ezejimofor M, Chen Y, Kandala N, Ezejimofor B, Ezeabasili A, Stranges S, et al. Stroke survivors in low- and middle-income countries: A meta-analysis of prevalence and secular trends. J Neurol Sci. 2016;364:68-76 pubmed publisher
    ..Improved stroke surveillance and care, as well as better management of the underlying risk factors, primarily undetected or uncontrolled high blood pressure (HBP) are needed.
  52. Zhang C, Hou X, Tan L, Shao C, Huang H, Li Y, et al. The Arabidopsis acetylated histone-binding protein BRAT1 forms a complex with BRP1 and prevents transcriptional silencing. Nat Commun. 2016;7:11715 pubmed publisher
    ..Thus, BRAT1 represents a potential link between histone acetylation and transcriptional anti-silencing at methylated genomic regions, which may be conserved in eukaryotes. ..
  53. Milivojevic M, Dangeard A, Kasper C, Tschon T, Emmenlauer M, Pique C, et al. ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria. PLoS Pathog. 2017;13:e1006224 pubmed publisher
    ..that TIFA/TRAF6-dependent cytokine expression is induced by the bacterial metabolite heptose-1,7-bisphosphate (HBP)...
  54. Rinfret F, Ouattara F, Cloutier L, Larochelle P, Ilinca M, Lamarre Cliche M. The impact of unrecorded readings on the precision and diagnostic performance of home blood pressure monitoring: a statistical study. J Hum Hypertens. 2018;32:197-202 pubmed publisher
    ..We obtained 103 HBP patients schedules from a previous study...
  55. Ricciardiello F, Votta G, Palorini R, Raccagni I, Brunelli L, Paiotta A, et al. Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis. Cell Death Dis. 2018;9:377 pubmed publisher
    ..protein glycosylation, frequently resulting from an augmented flux through the Hexosamine Biosynthetic Pathway (HBP), play different roles in tumor progression...
  56. Stergiou G, Ntineri A, Kollias A, Destounis A, Nasothimiou E, Roussias L. Changing relationship among clinic, home, and ambulatory blood pressure with increasing age. J Am Soc Hypertens. 2015;9:544-52 pubmed publisher
    Studies in adults have shown similar levels of home (HBP) and daytime ambulatory blood pressure (dABP), which are lower than clinic blood pressure (CBP) measurements. This study investigated the impact of age on these differences...
  57. Stefano G, Challenger S, Kream R. Hyperglycemia-associated alterations in cellular signaling and dysregulated mitochondrial bioenergetics in human metabolic disorders. Eur J Nutr. 2016;55:2339-2345 pubmed
    ..their cognate receptor for advanced glycation end-products (RAGEs), and (2) the hexosamine biosynthetic pathway (HBP)...
  58. Bentzer P, Fisher J, Kong H, Mörgelin M, Boyd J, Walley K, et al. Heparin-binding protein is important for vascular leak in sepsis. Intensive Care Med Exp. 2016;4:33 pubmed
    Elevated plasma levels of heparin-binding protein (HBP) are associated with risk of organ dysfunction and mortality in sepsis, but little is known about causality and mechanisms of action of HBP...
  59. Hu S, Jiang L, Zou X, Yi W, Tian D. Hepatitis B virus upregulates host expression of ?-1,2-mannosidases via the PPAR? pathway. World J Gastroenterol. 2016;22:9534-9543 pubmed
    ..individual viral genes of HBV (PTT22-HBx, PTT22-HBs, PTT22-preS2, PTT22-preS1, PTT22-HBc, PTT22-HBe, and PTT22-HBp) or control plasmids (PTT22-vector) were transfected into HepG2 cells...
  60. Kowshik J, Mishra R, Sophia J, Rautray S, Anbarasu K, Reddy G, et al. Nimbolide upregulates RECK by targeting miR-21 and HIF-1α in cell lines and in a hamster oral carcinogenesis model. Sci Rep. 2017;7:2045 pubmed publisher
    ..angiogenesis and Notch signalling in the 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis model, a paradigm for oral oncogenesis and chemointervention...
  61. Chang M, Guo F, Zhou Z, Huang X, Yi L, Dou Y, et al. HBP induces the expression of monocyte chemoattractant protein-1 via the FAK/PI3K/AKT and p38 MAPK/NF-κB pathways in vascular endothelial cells. Cell Signal. 2018;43:85-94 pubmed publisher
    ..PMNs mediate monocyte recruitment via their release of heparin binding protein (HBP), which activates CCR2 (CC-chemokine receptor 2) on monocytes...
  62. Kitagawa N, Ushigome E, Matsumoto S, Oyabu C, Ushigome H, Yokota I, et al. Prognostic significance of home pulse pressure for progression of diabetic nephropathy: KAMOGAWA-HBP study. Hypertens Res. 2018;41:363-371 pubmed publisher
    ..7 mmHg, 0.649 and 0.580, respectively. Our findings suggest, for the first time, that home PP is an independent predictor of the progression of diabetic nephropathy in patients with type 2 diabetes. ..
  63. Townley Tilson W, Pendergrass S, Marzluff W, Whitfield M. Genome-wide analysis of mRNAs bound to the histone stem-loop binding protein. RNA. 2006;12:1853-67 pubmed
    ..The histone mRNA 3' stem-loop is bound by the stem-loop binding protein (SLBP) that is involved in pre-mRNA processing, translation, and stability of histone mRNA...
  64. Yao B, Xu Y, Wang J, Qiao Y, Zhang Y, Zhang X, et al. Reciprocal regulation between O-GlcNAcylation and tribbles pseudokinase 2 (TRIB2) maintains transformative phenotypes in liver cancer cells. Cell Signal. 2016;28:1703-12 pubmed publisher
    ..TRIB2 can be O-GlcNAcylated by the hexosamine biosynthesis pathway (HBP)...
  65. Quijano Y, Vicente E, Ielpo B, Duran H, Diaz E, Fabra I, et al. Hepatobilio-pancreatic robotic surgery: initial experience from a single center institute. J Robot Surg. 2017;11:355-365 pubmed publisher
    The use of robotic surgery in the hepatobilio-pancreatic (HBP) field is still limited. Our aim is to present our early experience of robotic liver resection...
  66. Scott J, Oakhill J. The sweet side of AMPK signaling: regulation of GFAT1. Biochem J. 2017;474:1289-1292 pubmed publisher
    ..amidotransferase-1 (GFAT1), the rate-limiting enzyme of the hexosamine biosynthesis pathway (HBP), is a physiological substrate of AMPK...
  67. Du J, Zhong M, Liu D, Liang S, Liu X, Cheng B, et al. Reduced MLH3 Expression in the Syndrome of Gan-Shen Yin Deficiency in Patients with Different Diseases. Evid Based Complement Alternat Med. 2017;2017:4109828 pubmed publisher
    ..Fifty primary liver cancer (PLC) patients, 94 hypertension (HBP) patients, and 100 diabetes mellitus (DM) patients were enrolled and classified into gan-shen Yin deficiency group ..
  68. Nagini S, Kowshik J. The Hamster Buccal Pouch Model of Oral Carcinogenesis. Methods Mol Biol. 2016;1422:341-50 pubmed publisher
    The hamster buccal pouch (HBP) carcinogenesis model is one of the most well-characterized animal tumor models used as a prelude to investigate multistage oral carcinogenesis and to assess the efficacy of chemointervention...
  69. Sauvageau J, Bhasin M, Guo C, Adekoya I, Gray Owen S, Oscarson S, et al. Alternate synthesis to d-glycero-?-d-manno-heptose 1,7-biphosphate. Carbohydr Res. 2017;450:38-43 pubmed publisher
    d-glycero-?-d-manno-heptose 1,7-biphosphate (HBP) is an enzymatic intermediate in the biosynthesis of the heptose component of lipopolysaccharide (LPS), and was recently revealed to be a pathogen-associated molecular pattern (PAMP) that ..
  70. Park J, Rhee M, Namgung J, Lee S, Cho D, Choi T, et al. Comparison of Optimal Diagnostic Thresholds of Hypertension With Home Blood Pressure Monitoring and 24-Hour Ambulatory Blood Pressure Monitoring. Am J Hypertens. 2017;30:1170-1176 pubmed publisher
    Differences between the recently suggested outcome-driven diagnostic threshold of home blood pressure (HBP) measurements and the currently recommended diagnostic threshold of HBP measurements may cause a disagreement between 24-hour ..
  71. Allard P, Champigny M, Skoggard S, Erkmann J, Whitfield M, Marzluff W, et al. Stem-loop binding protein accumulates during oocyte maturation and is not cell-cycle-regulated in the early mouse embryo. J Cell Sci. 2002;115:4577-86 pubmed
    The stem-loop binding protein (SLBP) binds to the 3' end of histone mRNA and participates in 3'-processing of the newly synthesized transcripts, which protects them from degradation, and probably also promotes their translation...
  72. Li M, Tucker L, Asara J, Cheruiyot C, Lu H, Wu Z, et al. Stem-loop binding protein is a multifaceted cellular regulator of HIV-1 replication. J Clin Invest. 2016;126:3117-29 pubmed publisher
    ..This reduction was correlated with lower levels of stem-loop binding protein (SLBP), which is known to control histone metabolism...
  73. Zibrova D, Vandermoere F, Göransson O, Peggie M, Mariño K, Knierim A, et al. GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis. Biochem J. 2017;474:983-1001 pubmed publisher
    ..GFAT1 is the rate-limiting enzyme in the hexosamine biosynthesis pathway (HBP) and as such controls the modification of proteins by O-linked ?-N-acetylglucosamine (O-GlcNAc)..
  74. Simonyte S, Kuciene R, Medzioniene J, Dulskiene V, Lesauskaite V. Renin-angiotensin system gene polymorphisms and high blood pressure in Lithuanian children and adolescents. BMC Med Genet. 2017;18:100 pubmed publisher
    Epidemiological studies have demonstrated the influence of environmental factors on HBP in the population of Lithuanian children, although the role of genetic factors in hypertension has not yet been studied...
  75. Yoneyama M, Takayama Y, Nishie A, Nakamura M, Katsumata Y, Takemura A, et al. Differentiation of hypointense nodules on gadoxetic acid-enhanced hepatobiliary-phase MRI using T2 enhanced spin-echo imaging with the time-reversed gradient echo sequence: An initial experience. Eur J Radiol. 2017;95:325-331 pubmed publisher
    ..echo (T2FFE) and evaluate its utility for differentiating hypointensity nodules in the hepatobiliary phase (HBP) of gadoxetic acid-enhanced (Gd-EOB) MRI...
  76. Choe J, Ahn S, Kim Y. The mRNP remodeling mediated by UPF1 promotes rapid degradation of replication-dependent histone mRNA. Nucleic Acids Res. 2014;42:9334-49 pubmed publisher
    ..Here, we investigate remodeling of stem-loop binding protein (SLBP)-containing histone mRNPs occurring during the switch from the actively translating mode to the degradation mode...
  77. Tan M, Cao X, Li P, Zhai Y, Zhou Y, Liu Y, et al. Effectively enhancing cytotoxic and apoptotic effects of alpha-momorcharin by integrating a heparin-binding peptide. Biotechnol Appl Biochem. 2017;64:918-926 pubmed publisher
    ..a heparin-binding domain derived from heparin-binding epidermal growth factor (named heparin-binding peptide [HBP]) was used as a cell-penetrating peptide and fused to the C-terminus of ?-MMC...
  78. Dejaloud A, Vahabzadeh F, Habibi A. Ralstonia eutropha as a biocatalyst for desulfurization of dibenzothiophene. Bioprocess Biosyst Eng. 2017;40:969-980 pubmed publisher
    ..both conditions showed that sulfur was removed from DBT which accompanied by the formation of 2-hydroxybiphenyl (2-HBP)...
  79. Haj Yahia S, Ben Zvi I, Livneh A. Colchicine intoxication in familial Mediterranean fever patients using clarithromycin for the treatment of Helicobacter pylori: a series of six patients. Rheumatol Int. 2018;38:141-147 pubmed publisher
    ..All six patients were women who received colchicine for FMF, and clarithromycin for Helicobacter pylori (HBP) gastric infection. Their daily dosages of colchicine ranged from 1.5 to 2.5 mg...
  80. Sharma P, Dandamudi G, Herweg B, Wilson D, Singh R, Naperkowski A, et al. Permanent His-bundle pacing as an alternative to biventricular pacing for cardiac resynchronization therapy: A multicenter experience. Heart Rhythm. 2018;15:413-420 pubmed publisher
    ..Permanent His-bundle pacing (HBP) has been reported as an alternative option for CRT...
  81. Chen L, Simpson J, Fuchs A, Rolfe B, Thurecht K. Effects of Surface Charge of Hyperbranched Polymers on Cytotoxicity, Dynamic Cellular Uptake and Localization, Hemotoxicity, and Pharmacokinetics in Mice. Mol Pharm. 2017;: pubmed publisher
    ..Three methacrylate/methacrylamide-based monomers were used to synthesize well-defined hyperbranched polymers (HBP) by reversible addition-fragmentation chain transfer (RAFT) polymerization...
  82. Jordan A, Zhang X, Li J, Laulicht Glick F, Sun H, Costa M. Nickel and cadmium-induced SLBP depletion: A potential pathway to metal mediated cellular transformation. PLoS ONE. 2017;12:e0173624 pubmed publisher
    ..In this study, we found that there were slightly different effects on decreased SLBP mRNA and protein as well as increased polyA H3.1 in our nickel exposed cells...
  83. Luanpitpong S, Angsutararux P, Samart P, Chanthra N, Chanvorachote P, Issaragrisil S. Hyper-O-GlcNAcylation induces cisplatin resistance via regulation of p53 and c-Myc in human lung carcinoma. Sci Rep. 2017;7:10607 pubmed publisher
    Aberrant metabolism in hexosamine biosynthetic pathway (HBP) has been observed in several cancers, affecting cellular signaling and tumor progression...
  84. Ramu A, Kathiresan S, Ali Ahmed B. Gramine inhibits angiogenesis and induces apoptosis via modulation of TGF-? signalling in 7,12 dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinoma. Phytomedicine. 2017;33:69-76 pubmed publisher
    ..gramine through inhibiting TGF-? on DMBA induced oral squamous cell carcinoma (OSCC) in the hamster buccal pouch (HBP)...
  85. Lei X, Zhao D, Huang L, Luo Z, Zhang J, Yu X, et al. Childhood Health Outcomes in Term Large-for-Gestational-Age Babies with Different Postnatal Growth Patterns. Am J Epidemiol. 2017;: pubmed publisher
    ..and odds ratios (ORs) of obesity, growth restriction, low intelligence quotient (IQ) and high blood pressure (HBP) were calculated by logistic regression...
  86. Lorent K, Overbergh L, Delabie J, Van Leuven F, Van den Berghe H. Distribution of mRNA coding for alpha-2-macroglobulin, the murinoglobulins, the alpha-2-macroglobulin receptor and the alpha-2-macroglobulin receptor associated protein during mouse embryogenesis and in adult tissues. Differentiation. 1994;55:213-23 pubmed
    ..receptor (alpha 2MR) and the receptor associated protein, the heparin binding protein-44 (alpha 2MRAP/HBP-44), a component of unknown function...
  87. Zhou Z, Long L, Qiu W, Cheng G, Huang L, Yang T, et al. Comparison of 10- and 20-min hepatobiliary phase images on Gd-EOB-DTPA-enhanced MRI T1 mapping for liver function assessment in clinic. Abdom Radiol (NY). 2017;42:2272-2278 pubmed publisher
    To compare hepatobiliary phase (HBP) images obtained 10 and 20 min after Gd-EOB-DTPA-enhanced MRI for liver function assessment in clinic on 3.0 T MR imaging...
  88. Hugo S, Schlegel A. A Genetic Model to Study Increased Hexosamine Biosynthetic Flux. Endocrinology. 2017;158:2420-2426 pubmed publisher
    ..the sugar isomerase 1 domain of the gene encoding the rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP) glutamine-fructose-6-phosphate transamidase (Gfpt1). The mutated protein shows increased abundance...
  89. Stöckel A, Jenzen C, Thies M, Rückert U. Binary Associative Memories as a Benchmark for Spiking Neuromorphic Hardware. Front Comput Neurosci. 2017;11:71 pubmed publisher
    ..neural networks, are being developed around the world, for example as part of the European Human Brain Project (HBP)...
  90. Chen H, Li X, Liu S, Gu L, Zhou X. MircroRNA-19a promotes vascular inflammation and foam cell formation by targeting HBP-1 in atherogenesis. Sci Rep. 2017;7:12089 pubmed publisher
    ..We identify HMG-Box Transcription Factor 1 (HBP-1) as a target gene of miR-19a...
  91. Vijayaraman P, Dandamudi G, Zanon F, Sharma P, Tung R, Huang W, et al. Permanent His bundle pacing: Recommendations from a Multicenter His Bundle Pacing Collaborative Working Group for standardization of definitions, implant measurements, and follow-up. Heart Rhythm. 2018;15:460-468 pubmed publisher
    His bundle pacing (HBP) prevents ventricular dyssynchrony and its long-term consequences by preserving normal electrical activation of the ventricles...
  92. Choi S, Kim S, Park C, Min J, Lee J, Choi Y, et al. Imaging Features of Gadoxetic Acid-enhanced and Diffusion-weighted MR Imaging for Identifying Cytokeratin 19-positive Hepatocellular Carcinoma: A Retrospective Observational Study. Radiology. 2017;:162846 pubmed publisher
    ..001), lower tumor-to-liver signal intensity (SI) ratio on hepatobiliary phase (HBP) images (?0.522; P = .01), and lower tumor-to-liver apparent diffusion coefficient (ADC) ratio (?0.820; P < ...