Ski

Summary

Gene Symbol: Ski
Description: SKI proto-oncogene
Alias: SGS, SKV, ski oncogene, proto-oncogene c-Ski, ski oncoprotein, v-ski avian sarcoma viral oncogene homolog
Species: human
Products:     Ski

Top Publications

  1. Nomura N, Sasamoto S, Ishii S, Date T, Matsui M, Ishizaki R. Isolation of human cDNA clones of ski and the ski-related gene, sno. Nucleic Acids Res. 1989;17:5489-500 pubmed
    cDNA clones of ski and the ski-related gene, sno, were obtained by screening human cDNA libraries. The predicted open reading frame of h-ski could encode a protein of 728 amino acid residues...
  2. Reed J, Bales E, Xu W, Okan N, Bandyopadhyay D, Medrano E. Cytoplasmic localization of the oncogenic protein Ski in human cutaneous melanomas in vivo: functional implications for transforming growth factor beta signaling. Cancer Res. 2001;61:8074-8 pubmed
    The oncogenic protein Ski associates with Smad proteins and counteracts their activation of gene expression and growth inhibition in response to transforming growth factor beta (TGF-beta)...
  3. Suzuki H, Yagi K, Kondo M, Kato M, Miyazono K, Miyazawa K. c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements. Oncogene. 2004;23:5068-76 pubmed
    c-Ski inhibits transforming growth factor-beta (TGF-beta) signaling through interaction with Smad proteins. c-Ski represses Smad-mediated transcriptional activation, probably through its action as a transcriptional co-repressor...
  4. Chen W, Lam S, Srinath H, Schiffer C, Royer W, Lin K. Competition between Ski and CREB-binding protein for binding to Smad proteins in transforming growth factor-beta signaling. J Biol Chem. 2007;282:11365-76 pubmed
    ..Smads repress or activate TGF-beta signaling by interacting with corepressors (e.g. Ski) or coactivators (e.g. CREB-binding protein (CBP)), respectively...
  5. Chen D, Lin Q, Box N, ROOP D, Ishii S, Matsuzaki K, et al. SKI knockdown inhibits human melanoma tumor growth in vivo. Pigment Cell Melanoma Res. 2009;22:761-72 pubmed publisher
    The SKI protein represses the TGF-beta tumor suppressor pathway by associating with the Smad transcription factors...
  6. Nagano Y, Koinuma D, Miyazawa K, Miyazono K. Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells. J Biochem. 2010;147:545-54 pubmed publisher
    ..e. Smad7, c-Ski and SnoN. In the present study, we examined the roles of Arkadia in human cancer cells...
  7. Dahl R, Wani B, Hayman M. The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42. Oncogene. 1998;16:1579-86 pubmed
    The v-Ski avian retroviral oncogene is postulated to act as a transcription factor...
  8. Nomura T, Khan M, Kaul S, Dong H, Wadhwa R, Colmenares C, et al. Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor. Genes Dev. 1999;13:412-23 pubmed
    ..The proteins encoded by the ski proto-oncogene family directly bind to N-CoR/SMRT and mSin3A, and forms a complex with HDAC...
  9. Luo K, Stroschein S, Wang W, Chen D, Martens E, Zhou S, et al. The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling. Genes Dev. 1999;13:2196-206 pubmed
    ..Here we show that a nuclear oncoprotein, Ski, can interact directly with Smad2, Smad3, and Smad4 on a TGFbeta-responsive promoter element and repress their ..

More Information

Publications109 found, 100 shown here

  1. Akiyoshi S, Inoue H, Hanai J, Kusanagi K, Nemoto N, Miyazono K, et al. c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads. J Biol Chem. 1999;274:35269-77 pubmed
    ..We identified c-Ski as a Smad2 interacting protein. c-Ski is the cellular homologue of the v-ski oncogene product and has been shown to repress transcription by recruiting histone deacetylase (HDAC)...
  2. Prunier C, Pessah M, Ferrand N, Seo S, Howe P, Atfi A. The oncoprotein Ski acts as an antagonist of transforming growth factor-beta signaling by suppressing Smad2 phosphorylation. J Biol Chem. 2003;278:26249-57 pubmed
    ..The transcriptional activity of Smad2-Smad4 or Smad3-Smad4 complexes can be limited by the corepressor Ski, which is believed to interact with Smad complexes on TGF-beta-responsive promoters and represses their ability to ..
  3. Ueki N, Hayman M. Direct interaction of Ski with either Smad3 or Smad4 is necessary and sufficient for Ski-mediated repression of transforming growth factor-beta signaling. J Biol Chem. 2003;278:32489-92 pubmed
    The oncoprotein Ski represses transforming growth factor (TGF)-beta signaling in an N-CoR-independent manner. However, the molecular mechanism(s) underlying this event has not been elucidated...
  4. Ueki N, Zhang L, Hayman M. Ski negatively regulates erythroid differentiation through its interaction with GATA1. Mol Cell Biol. 2004;24:10118-25 pubmed
    The Ski oncoprotein dramatically affects cell growth, differentiation, and/or survival...
  5. Le Scolan E, Zhu Q, Wang L, Bandyopadhyay A, Javelaud D, Mauviel A, et al. Transforming growth factor-beta suppresses the ability of Ski to inhibit tumor metastasis by inducing its degradation. Cancer Res. 2008;68:3277-85 pubmed publisher
    c-Ski is an important corepressor of transforming growth factor-beta (TGF-beta) signaling through its ability to bind to and repress the activity of the Smad proteins...
  6. Qin B, Lam S, Correia J, Lin K. Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control. Genes Dev. 2002;16:1950-63 pubmed
    ..Smad3 dissociates from SARA and enters the nucleus, in which its transcriptional activity can be repressed by Ski. Here, we show that SARA and Ski recognize specifically the monomeric and trimeric forms of Smad3, respectively...
  7. Wu J, Krawitz A, Chai J, Li W, Zhang F, Luo K, et al. Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling. Cell. 2002;111:357-67 pubmed
    The Ski family of nuclear oncoproteins represses TGF-beta signaling through interactions with the Smad proteins...
  8. Fukuchi M, Nakajima M, Fukai Y, Miyazaki T, Masuda N, Sohda M, et al. Increased expression of c-Ski as a co-repressor in transforming growth factor-beta signaling correlates with progression of esophageal squamous cell carcinoma. Int J Cancer. 2004;108:818-24 pubmed
    ..esophageal SCC maintains these components was investigated, with particular emphasis on the participation of c-Ski and SnoN as transcriptional co-repressors in TGF-beta signaling...
  9. Nagano Y, Mavrakis K, Lee K, Fujii T, Koinuma D, Sase H, et al. Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling. J Biol Chem. 2007;282:20492-501 pubmed
    ..Smad7 antagonizes TGF-beta signaling mainly through targeting the signaling receptors, whereas SnoN and c-Ski repress signaling at the transcriptional level through inactivation of Smad complexes...
  10. Teichler S, Illmer T, Roemhild J, Ovcharenko D, Stiewe T, Neubauer A. MicroRNA29a regulates the expression of the nuclear oncogene Ski. Blood. 2011;118:1899-902 pubmed publisher
    ..In conclusion, up-regulation of Ski in AML with -7/del7q is caused by loss of miR-29a. miR-29a may therefore function as an important tumor suppressor in AML by restraining expression of the SKI oncogene.
  11. Ritter M, Kattmann D, Teichler S, Hartmann O, Samuelsson M, Burchert A, et al. Inhibition of retinoic acid receptor signaling by Ski in acute myeloid leukemia. Leukemia. 2006;20:437-43 pubmed
    ..b>SKI, a nuclear oncogene, was highly up regulated...
  12. Ghosh M, Öner D, Poels K, Tabish A, Vlaanderen J, Pronk A, et al. Changes in DNA methylation induced by multi-walled carbon nanotube exposure in the workplace. Nanotoxicology. 2017;:1-16 pubmed publisher
    ..serine/threonine kinase (NPAT/ATM)], and a potential transforming growth factor beta (TGF-?) repressor [SKI proto-oncogene (SKI)] were studied using bisulfite pyrosequencing...
  13. Wang Y, Yang B, Zhou G, Zhang F. Two Cases of Dermatitis Herpetiformis Successfully Treated with Tetracycline and Niacinamide. Acta Dermatovenerol Croat. 2018;26:273-275 pubmed
    ..examination showed subepidermal blisters and accumulation of neutrophils at the papillary dermis of the involved ski. Direct immunofluorescence revealed fibrillar deposition of IgA on the dermal papillae (Figure 1. g, h)...
  14. Öner D, Ghosh M, Bové H, Moisse M, Boeckx B, Duca R, et al. Differences in MWCNT- and SWCNT-induced DNA methylation alterations in association with the nuclear deposition. Part Fibre Toxicol. 2018;15:11 pubmed publisher
    ..On the other hand, SWCNT exposure showed hypermethylation on functionally important genes, such as SKI proto-oncogene (SKI), glutathione S-transferase pi 1 (GTSP1) and shroom family member 2 (SHROOM2) and ..
  15. Cieślik M, Czapski G, Strosznajder J. The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins. PLoS ONE. 2015;10:e0137193 pubmed publisher
    ..PC12 cells were subjected to Aβ1-42 oligomers and SphK inhibitor SKI II for 24-96 h...
  16. Hébert Losier K, Zinner C, Platt S, Stoggl T, Holmberg H. Factors that Influence the Performance of Elite Sprint Cross-Country Skiers. Sports Med. 2017;47:319-342 pubmed publisher
    ..techniques, and use better coordinated movements to optimize generation of propulsive force from the resultant ski and pole forces...
  17. Bakar A, Park S, Kim M, Lee H. Isoflurane protects against human endothelial cell apoptosis by inducing sphingosine kinase-1 via ERK MAPK. Int J Mol Sci. 2012;13:977-93 pubmed publisher
    ..hy926 cells. Finally, selective blockade of SK1 (with SKI-II) or S1P(1) receptor (with W146) abolished the anti-apoptotic effects of isoflurane...
  18. Bougault C, El Jamal A, Briolay A, Mebarek S, Boutet M, Garraud T, et al. Involvement of sphingosine kinase/sphingosine 1-phosphate metabolic pathway in spondyloarthritis. Bone. 2017;103:150-158 pubmed publisher
    ..Using the pharmacological drugs SKi (SK pan-inhibitor), PF-543 (SK1 specific inhibitor) or K-145 (SK2 specific inhibitor), we showed that the ..
  19. Wang Y, Xiao Y, Li S, Shi L, Liu L, Zhang Y, et al. BMP-7 enhances SnoN mRNA expression in renal tubular epithelial cells under high-glucose conditions. Mol Med Rep. 2017;16:3308-3314 pubmed publisher
    ..bone morphogenetic protein‑7 (BMP‑7) and the expression of the transcriptional co‑repressor Ski‑related novel protein N (SnoN), in addition to alterations in tubulointerstitial fibrosis, during the ..
  20. Rodríguez Cousiño N, Esteban R. Relationships and Evolution of Double-Stranded RNA Totiviruses of Yeasts Inferred from Analysis of L-A-2 and L-BC Variants in Wine Yeast Strain Populations. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..This requirement is overcome when coat proteins are provided in large amounts by a vector or in ski mutants...
  21. Richardson J, Sethi G, Lee G, Malek S. Chalepin: isolated from Ruta angustifolia L. Pers induces mitochondrial mediated apoptosis in lung carcinoma cells. BMC Complement Altern Med. 2016;16:389 pubmed
    ..were tested for its cytotoxicity using the sulforhodamide (SRB) cytotoxicity assay against HCT-116, A549, Ca Ski and MRC5 cell lines...
  22. Pyszko J, Strosznajder J. The key role of sphingosine kinases in the molecular mechanism of neuronal cell survival and death in an experimental model of Parkinson's disease. Folia Neuropathol. 2014;52:260-9 pubmed
    ..were treated with MPP+ (1-3 mM), which represents an experimental PD model, or with the Sphks inhibitor (1-5 µM SKI II) for 3-24 h...
  23. Achilleos A, Huffman N, Marcinkiewicyz E, Seidah N, Chen Q, Dallas S, et al. MBTPS1/SKI-1/S1P proprotein convertase is required for ECM signaling and axial elongation during somitogenesis and vertebral development†. Hum Mol Genet. 2015;24:2884-98 pubmed publisher
    ..We discovered that MBTPS1/SKI-1/S1P, which proteolytically activates a class of transmembrane transcription factors, plays a critical role in ..
  24. Bhat V, Bernhart E, Plastira I, Fan K, Ghaffari Tabrizi Wizsy N, Wadsack C, et al. Pharmacological Inhibition of Serine Palmitoyl Transferase and Sphingosine Kinase-1/-2 Inhibits Merkel Cell Carcinoma Cell Proliferation. J Invest Dermatol. 2019;139:807-817 pubmed publisher
    ..We used myriocin (a serine palmitoyl transferase antagonist) and two SK inhibitors (SKI-II and ABC294640)...
  25. Wagner W, Ciszewski W, Kania K. L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation. Cell Commun Signal. 2015;13:36 pubmed publisher
    ..Three cervical cancer cell lines were examined: HeLa, Ca Ski and C33A. The inhibitory activity of lactate on HDACs was analysed using Western blot and biochemical methods...
  26. Seidah N, Abifadel M, Prost S, Boileau C, Prat A. The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9. Pharmacol Rev. 2017;69:33-52 pubmed
    ..PC2, furin, PC4, PC5/6, paired basic amino acid cleaving enzyme 4, PC7, subtilisin kexin isozyme 1/site 1 protease (SKI-1/S1P), and PC subtilisin/kexin type 9 (PCSK9)...
  27. Catterall W. Forty Years of Sodium Channels: Structure, Function, Pharmacology, and Epilepsy. Neurochem Res. 2017;42:2495-2504 pubmed publisher
    ..Bruce Ransom and I re-connected in the 1990s, as ski buddies at the Winter Conference on Brain Research and as faculty colleagues at the University of Washington when ..
  28. Mistry D, Tsutsumi R, Fernandez M, Sharma S, Cardenas S, Lawson M, et al. Gonadotropin-releasing hormone pulse sensitivity of follicle-stimulating hormone-beta gene is mediated by differential expression of positive regulatory activator protein 1 factors and corepressors SKIL and TGIF1. Mol Endocrinol. 2011;25:1387-403 pubmed publisher
    ..Overexpression of binding or phosphorylation-defective ski-oncogene-like protein (SKIL) and TG interacting factor (TGIF1) mutants, however, failed to repress Fshb promoter ..
  29. Sandbakk Ã, Rasdal V, BrÃ¥ten S, Moen F, Ettema G. How Do World-Class Nordic Combined Athletes Differ From Specialized Cross-Country Skiers and Ski Jumpers in Sport-Specific Capacity and Training Characteristics?. Int J Sports Physiol Perform. 2016;11:899-906 pubmed
    ..laboratory capacities and the annual training of world-class Nordic combined (NC) athletes with specialized ski jumpers (SJ) and cross-country (XC) skiers. Five world-class athletes from each sports discipline were compared...
  30. Wang W, Mariani F, Harland R, Luo K. Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells. Proc Natl Acad Sci U S A. 2000;97:14394-9 pubmed
    ..Here, we show that the Ski oncoprotein can block BMP signaling and the expression of BMP-responsive genes in both Xenopus and mammalian cells by ..
  31. Tan R, Zhang J, Tan X, Zhang X, Yang J, Liu Y. Downregulation of SnoN expression in obstructive nephropathy is mediated by an enhanced ubiquitin-dependent degradation. J Am Soc Nephrol. 2006;17:2781-91 pubmed
    ..SnoN constitutively interacted with another Smad co-repressor, Ski, and they formed ternary complex with Smad2/3 upon TGF-beta1 stimulation...
  32. Hull C, Rajendran D, Fernandez Barnes A. Deep Vein Thrombosis and Pulmonary Embolism in a Mountain Guide: Awareness, Diagnostic Challenges, and Management Considerations at Altitude. Wilderness Environ Med. 2016;27:100-6 pubmed publisher
    ..of thrombosis in mountain athletes is uncharted, but lowlanders increasingly go to high altitude to trek, ski, or climb...
  33. Tarakçi D, Ersoz Huseyinsinoglu B, Tarakci E, Razak Ozdincler A. Effects of Nintendo Wii-Fit® video games on balance in children with mild cerebral palsy. Pediatr Int. 2016;58:1042-1050 pubmed publisher
    ..group received conventional balance training in each session, the Wii group played Nintendo Wii Fit games such as ski slalom, tightrope walk and soccer heading on balance board...
  34. Richards E, Martin C. Adaptive introgression from distant Caribbean islands contributed to the diversification of a microendemic adaptive radiation of trophic specialist pupfishes. PLoS Genet. 2017;13:e1006919 pubmed publisher
    ..For example, standing variation in a proto-oncogene (ski) known to have effects on jaw size introgressed into one San Salvador Island specialist from an island 300 km away ..
  35. Gołaś A, Wilk M, Stastny P, Maszczyk A, Pajerska K, Zajac A. Optimizing Half Squat Postactivation Potential Load in Squat Jump Training for Eliciting Relative Maximal Power in Ski Jumpers. J Strength Cond Res. 2017;31:3010-3017 pubmed publisher
    ..Optimizing half squat postactivation potential load in squat jump training for eliciting relative maximal power in ski jumpers...
  36. Kinugawa Y, Uehara T, Matsuda K, Kobayashi Y, Nakajima T, Hamano H, et al. Promoter hypomethylation of SKI in autoimmune pancreatitis. Pathol Res Pract. 2018;214:492-497 pubmed publisher
    ..We identified SKI might have a significant methylation abnormality in AIP through methylation array analysis using the Illumina ..
  37. Cingolani F, Casasampere M, Sanllehí P, Casas J, Bujons J, Fabrias G. Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II. J Lipid Res. 2014;55:1711-20 pubmed publisher
    Sphingosine kinase inhibitor (SKI) II has been reported as a dual inhibitor of sphingosine kinases (SKs) 1 and 2 and has been extensively used to prove the involvement of SKs and sphingosine-1-phosphate (S1P) in cellular processes...
  38. Qin M, Dong X, Jing Y, Wei X, Wang Z, Feng H, et al. A Waterborne Gastroenteritis Outbreak Caused by Norovirus GII.17 in a Hotel, Hebei, China, December 2014. Food Environ Virol. 2016;8:180-6 pubmed publisher
    ..During this time, an outbreak of gastroenteritis occurred at a hotel in a ski park in Hebei Province, China...
  39. Turkçu G, Alabalık U, Keles A, Ibiloğlu I, Kucukoner M, Sen H, et al. Comparison of SKIP expression in malignant pleural mesotheliomas with Ki-67 proliferation index and prognostic parameters. Pol J Pathol. 2016;67:108-13 pubmed
    We aimed to determine the presence of SKI-interacting protein (SKIP) expression in malignant pleural mesothelioma (MPM) and its effect on prognosis by investigating SKIP correlation with the Ki-67 proliferation index and prognostic ..
  40. Evstratova V, Nikityuk D, Riger N, Fedyanina N, Khanferyan R. Evaluation In Vitro of Immunoregulatory Cytokines Secretion by Dendritic Cells in Mountain Skiers. Bull Exp Biol Med. 2016;162:60-62 pubmed
    ..IL-7, IL-1RA, IL-1?, IL-10, IL-15, IL-21, IL-22, IL-23, IL-27, and IL-9) by dendritic cell cultures was compared in ski athletes and healthy donors...
  41. Liu C, Jiang J, Gu J, Yu Z, Wang T, Lu H. High-dimensional omics data analysis using a variable screening protocol with prior knowledge integration (SKI). BMC Syst Biol. 2016;10:118 pubmed publisher
    ..In this study, we proposed an integrative prescreening approach, SKI, for high-throughput data analysis...
  42. Sun H, Samra N, Kalakoti P, Sharma K, Patra D, Dossani R, et al. Impact of Prehospital Transportation on Survival in Skiers and Snowboarders with Traumatic Brain Injury. World Neurosurg. 2017;104:909-918.e8 pubmed publisher
    ..findings suggest prehospital helicopter transport improved survival in patients incurring TBI after snowboard- or ski-related falls compared with those transported via ground EMS...
  43. Anderson P, Bovard R, Murad M, Beebe T, Wang Z. Health status and health behaviors among citizen endurance Nordic skiers in the United States. BMC Res Notes. 2017;10:305 pubmed publisher
    ..2014, we emailed a 48 question online survey to 23,611 individuals who had participated in the American Birkebeiner ski event, the largest citizen ski race in North America. Descriptive statistics were used to summarize data...
  44. Stroschein S, Wang W, Zhou S, Zhou Q, Luo K. Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein. Science. 1999;286:771-4 pubmed
    ..Thus, SnoN maintains the repressed state of TGF-beta-responsive genes in the absence of ligand and participates in negative feedback regulation of TGF-beta signaling. ..
  45. McNaughton M, Pitman M, Pitson S, Pyne N, Pyne S. Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells. Oncotarget. 2016;7:16663-75 pubmed publisher
    ..ABC294640 (3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide) or the SK1/SK2 inhibitor, SKi (2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole)) induce the proteasomal degradation of SK1a (Mr = 42 kDa) and ..
  46. Fasel B, Praz C, Kayser B, Aminian K. Measuring spatio-temporal parameters of uphill ski-mountaineering with ski-fixed inertial sensors. J Biomech. 2016;49:3052-3055 pubmed publisher
    ..the diagonal stride in classical cross-country skiing was adapted to compute spatio-temporal parameters for uphill ski mountaineering using a ski fixed inertial sensor...
  47. Spörri J, Kröll J, Gilgien M, Muller E. How to Prevent Injuries in Alpine Ski Racing: What Do We Know and Where Do We Go from Here?. Sports Med. 2017;47:599-614 pubmed publisher
    Alpine ski racing is known to be a sport with a high risk of injury and a high proportion of time-loss injuries...
  48. Karl J, Margolis L, Madslien E, Murphy N, Castellani J, Gundersen Y, et al. Changes in intestinal microbiota composition and metabolism coincide with increased intestinal permeability in young adults under prolonged physiological stress. Am J Physiol Gastrointest Liver Physiol. 2017;312:G559-G571 pubmed publisher
    ..three rations per day with or without protein- or carbohydrate-based supplements during a 4-day cross-country ski-march (STRESS). IP was measured before and during STRESS...
  49. Nybäck L, Glännerud C, Larsson G, Weitzberg E, Shannon O, McGawley K. Physiological and performance effects of nitrate supplementation during roller-skiing in normoxia and normobaric hypoxia. Nitric Oxide. 2017;70:1-8 pubmed publisher
    ..supplementation ingested in the form of concentrated beetroot juice on cross-country roller-ski performance in normoxia (N) and normobaric hypoxia (H)...
  50. Bailly N, Laporte J, Afquir S, Masson C, Donnadieu T, Delay J, et al. Effect of Helmet Use on Traumatic Brain Injuries and Other Head Injuries in Alpine Sport. Wilderness Environ Med. 2018;29:151-158 pubmed publisher
    ..From 2012 to 2014, data on the injured population were collected by physicians in on-mountain clinics in 30 French ski resorts, and interviews were conducted on the slope to sample a noninjured control population...
  51. Lanyon Hogg T, Masumoto N, Bodakh G, Konitsiotis A, Thinon E, Rodgers U, et al. Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase. Anal Biochem. 2015;490:66-72 pubmed publisher
    ..Quantification of the potency of RU-SKI small molecule Hhat inhibitors by click-ELISA indicated IC50 values in the low- or sub-micromolar range...
  52. El Alaoui A, Rabhi I. [Bilateral rupture of the anterior cruciate ligament in a ski player treated with DIDT by arthroscopic surgery in one time]. Pan Afr Med J. 2016;23:37 pubmed publisher
    We report the case of a 25-year-old patient who suffered a ski accident that causing a serious knees sprain. The patient underwent immobilization by plaster knees...
  53. Jelsma L, Smits Engelsman B, Krijnen W, Geuze R. Changes in dynamic balance control over time in children with and without Developmental Coordination Disorder. Hum Mov Sci. 2016;49:148-59 pubmed publisher
    ..Analyses of force plate variables showed that the TD group initially used a longer path length for the ski slope descent and tended toward more variation in Center of Pressure (CoP) displacement in lateral direction than ..
  54. Breton M, Chernavvsky D, Forlenza G, DeBoer M, Robic J, Wadwa R, et al. Closed-Loop Control During Intense Prolonged Outdoor Exercise in Adolescents With Type 1 Diabetes: The Artificial Pancreas Ski Study. Diabetes Care. 2017;40:1644-1650 pubmed publisher
    ..In a randomized controlled trial, 32 adolescents with T1D (ages 10-16 years) participated in a 5-day ski camp (∼5 h skiing/day) at two sites: Wintergreen, VA, and Breckenridge, CO...
  55. West J. A strategy for oxygen conditioning at high altitude: comparison with air conditioning. J Appl Physiol (1985). 2015;119:719-23 pubmed publisher
    Large numbers of people live or work at high altitude, and many visit to trek or ski. The inevitable hypoxia impairs physical working capacity, and at higher altitudes there is also cognitive impairment...
  56. Gorski J, Huffman N, Vallejo J, Brotto L, Chittur S, Breggia A, et al. Deletion of Mbtps1 (Pcsk8, S1p, Ski-1) Gene in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age. J Biol Chem. 2016;291:4308-22 pubmed publisher
    ..Understanding bone-muscle cross-talk may provide a fresh and novel approach to prevention and treatment of age-related muscle loss. ..
  57. Lochner S, Scherr M, Perl M, Grove C. [Severe blunt thoracic trauma caused by ski collision]. Unfallchirurg. 2017;120:162-166 pubmed publisher
    An approximately 25-year-old skier collided in a ski-run intersection. At high speed, he first hit another skier and then smashed into a snow cannon. He died from his injuries a short time later in hospital...
  58. Zhuang C, Zhou Z, Illman W. A Joint Analytic Method for Estimating Aquitard Hydraulic Parameters. Ground Water. 2017;55:565-576 pubmed publisher
    The vertical hydraulic conductivity (Kv ), elastic (Sske ), and inelastic (Sskv ) skeletal specific storage of aquitards are three of the most critical parameters in land subsidence investigations...
  59. Fasel B, Spörri J, Schütz P, Lorenzetti S, Aminian K. An Inertial Sensor-Based Method for Estimating the Athlete's Relative Joint Center Positions and Center of Mass Kinematics in Alpine Ski Racing. Front Physiol. 2017;8:850 pubmed publisher
    ..e., the projection of the outer ankle-CoM vector onto the line corresponding to the projection of ski's longitudinal axis on the snow surface)...
  60. Alexopoulos E, Kalyva A, Merekoulias G, Niakas D. Monitoring interhospital transfers in Western Greece during 2003-2011: its role in health policy. Rural Remote Health. 2015;15:3228 pubmed
    ..of Aigio, (b) lack of orthopedists at GH Kalavryta, which could provide a 24 hour emergency service in a tourist ski area, (c) understaffing in the microbiological laboratory and lack of a CT scanner at GH Mesologi, and (d) lack of ..
  61. Scopp J, Moorman C. Acute athletic trauma to the hip and pelvis. Orthop Clin North Am. 2002;33:555-63 pubmed
    Athletic trauma to the hip and pelvis is rare; however, as football players hit harder and skiers ski faster, the incidence of high-energy hip and pelvis trauma can be expected to increase...
  62. Steffan J, Kazantsev A, Spasic Boskovic O, Greenwald M, Zhu Y, Gohler H, et al. The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription. Proc Natl Acad Sci U S A. 2000;97:6763-8 pubmed
    ..These results raise the possibility that expanded repeat htt causes aberrant transcriptional regulation through its interaction with cellular transcription factors which may result in neuronal dysfunction and cell death in HD. ..
  63. Lu W, Volcik K, Zhu H, Wen S, Shaw G, Lammer E, et al. Genetic variation in the proto-oncogene SKI and risk for orofacial clefting. Mol Genet Metab. 2005;86:412-6 pubmed
    b>SKI is a proto-oncogene that is required for development of the central nervous system and skeletal muscle, and is involved in specifying selected cranial neural-crest-derived craniofacial structures...
  64. Villanacci V, Bellone G, Battaglia E, Rossi E, Carbone A, Prati A, et al. Ski/SnoN expression in the sequence metaplasia-dysplasia-adenocarcinoma of Barrett's esophagus. Hum Pathol. 2008;39:403-9 pubmed publisher
    ..factor-beta growth inhibition is considered a hallmark of several human neoplasms, we evaluated the expression of Ski and SnoN (proteins that antagonize transforming growth factor-beta signaling through physical interaction with Smad ..
  65. Tabata T, Kokura K, Ten Dijke P, Ishii S. Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5. Genes Cells. 2009;14:17-28 pubmed publisher
    The products encoded by ski and its related gene, sno, (Ski and Sno) act as transcriptional co-repressors and interact with other co-repressors such as N-CoR/SMRT and mSin3A...
  66. Schweighofer C, Coombes K, Barron L, Diao L, Newman R, Ferrajoli A, et al. A two-gene signature, SKI and SLAMF1, predicts time-to-treatment in previously untreated patients with chronic lymphocytic leukemia. PLoS ONE. 2011;6:e28277 pubmed publisher
    ..Two genes were consistently retained in the models with clinical variables: SKI (v-SKI avian sarcoma viral oncogene homolog) and SLAMF1 (signaling lymphocytic activation molecule family member 1; ..
  67. Smith M, Brunton H, Rowling E, Ferguson J, Arozarena I, Miskolczi Z, et al. Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy. Cancer Cell. 2016;29:270-284 pubmed publisher
    ..We demonstrate that inhibiting a driver of MAPKi-induced drug tolerance could improve current approaches of targeted melanoma therapy. ..
  68. Geelen I, Thielen N, Janssen J, Hoogendoorn M, Roosma T, Willemsen S, et al. Treatment outcome in a population-based, 'real-world' cohort of patients with chronic myeloid leukemia. Haematologica. 2017;102:1842-1849 pubmed publisher
    ..The 6-year cumulative incidence of eligibility for a tyrosine kinase cessation attempt, according to EURO-SKI criteria, was 31%...
  69. Steenstrup S, Mok K, McIntosh A, Bahr R, Krosshaug T. Reconstruction of head impacts in FIS World Cup alpine skiing. Br J Sports Med. 2017;: pubmed publisher
    Prior to the 2013/2014 season, the International Ski Federation (FIS) increased the helmet testing speed from 5.4 to 6.8?m/s for alpine downhill, super-G and giant slalom...
  70. Mangold E, Reutter H, Leon Cachon R, Ludwig K, Herms S, Chacon Camacho O, et al. Evaluating SKI as a candidate gene for non-syndromic cleft lip with or without cleft palate. Eur J Oral Sci. 2012;120:373-7 pubmed publisher
    ..Findings in mice suggest that the v-ski sarcoma viral oncogene homolog (SKI) gene is a candidate gene for orofacial clefting...
  71. Melling M, Friendship C, Shepherd T, Drysdale T. Expression of Ski can act as a negative feedback mechanism on retinoic acid signaling. Dev Dyn. 2013;242:604-13 pubmed publisher
    ..The nuclear protein Ski has been extensively studied for its ability to suppress transforming growth factor-beta (TGF-?) signaling but has ..
  72. Boccia G, Dardanello D, Zoppirolli C, Bortolan L, Cescon C, Schneebeli A, et al. Central and peripheral fatigue in knee and elbow extensor muscles after a long-distance cross-country ski race. Scand J Med Sci Sports. 2017;27:945-955 pubmed publisher
    ..Nevertheless, both KE and EE showed central and peripheral fatigue, suggesting that the origins of the strength impairments were multifactorial for the two muscles...
  73. Gallo Oller G, Vollmann Zwerenz A, Melendez B, Rey J, Hau P, Dotor J, et al. P144, a Transforming Growth Factor beta inhibitor peptide, generates antitumoral effects and modifies SMAD7 and SKI levels in human glioblastoma cell lines. Cancer Lett. 2016;381:67-75 pubmed publisher
    ..SMAD2 phosphorylation was reduced, together with a downregulation of SKI and an upregulation of SMAD7 at both transcriptional and translational levels...
  74. Zhang H, Yan T, Liu Z, Wang J, Lu Y, Li D, et al. MicroRNA-137 is negatively associated with clinical outcome and regulates tumor development through EZH2 in cervical cancer. J Cell Biochem. 2018;119:938-947 pubmed publisher
    ..CC cell lines, Ca-Ski, and SiHa cells were transduced with lentivirus to ectopically upregulate endogenous miR-137 expressions...
  75. Cui Z, Tong A, Huo Y, Yan Z, Yang W, Yang X, et al. SKIP controls flowering time via the alternative splicing of SEF pre-mRNA in Arabidopsis. BMC Biol. 2017;15:80 pubmed publisher
    ..b>Ski-interacting protein (SKIP), a splicing factor, is essential for circadian clock function and abiotic stress ..
  76. Thomson G, Wilson N. Local and regional smokefree and tobacco-free action in New Zealand: highlights and directions. N Z Med J. 2017;130:89-101 pubmed
    ..There has been progress in the areas of smokefree dining, large outdoor worksites and ski fields, and parts of downtown areas such as squares and streets...
  77. Sarkar A, Thoms M, Barrio Garcia C, Thomson E, Flemming D, Beckmann R, et al. Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality control. Nat Struct Mol Biol. 2017;: pubmed publisher
    ..To overcome this translational stress, the cytoplasmic surveillance machineries RQC and Ski-exosome target these malfunctioning ribosomes...
  78. Yuan X, Li D, Chen X, Han C, Xu L, Huang T, et al. Extracellular vesicles from human-induced pluripotent stem cell-derived mesenchymal stromal cells (hiPSC-MSCs) protect against renal ischemia/reperfusion injury via delivering specificity protein (SP1) and transcriptional activating of sphingosine ki. Cell Death Dis. 2017;8:3200 pubmed publisher
    ..Moreover, SP1 inhibition (MIT) or SK1 inhibition (SKI-II) completely abolished the renal protective effect of hiPSC-MSCs-EVs in rat I/R injury mode...
  79. Chaganti R, Balazs I, Jhanwar S, Murty V, Koduru P, Grzeschik K, et al. The cellular homologue of the transforming gene of SKV avian retrovirus maps to human chromosome region 1q22----q24. Cytogenet Cell Genet. 1986;43:181-6 pubmed
    We report the chromosomal localization of the cellular oncogene SKI, the putative oncogene of the Sloan-Kettering viruses (SKVs), a group of transforming retroviruses that had been isolated from chicken embryo cells infected with the ..
  80. Khan M, Nomura T, Kim H, Kaul S, Wadhwa R, Shinagawa T, et al. Role of PML and PML-RARalpha in Mad-mediated transcriptional repression. Mol Cell. 2001;7:1233-43 pubmed
    ..Here we show that PML interacts with multiple corepressors (c-Ski, N-CoR, and mSin3A) and histone deacetylase 1, and that this interaction is required for transcriptional repression ..
  81. Kokura K, Kim H, Shinagawa T, Khan M, Nomura T, Ishii S. The Ski-binding protein C184M negatively regulates tumor growth factor-beta signaling by sequestering the Smad proteins in the cytoplasm. J Biol Chem. 2003;278:20133-9 pubmed
    b>Ski is a transcriptional co-repressor and is involved in the negative regulation of tumor growth factor-beta (TGF-beta) signaling...
  82. Zhao H, Ueki N, Marcelain K, Hayman M. The Ski protein can inhibit ligand induced RARalpha and HDAC3 degradation in the retinoic acid signaling pathway. Biochem Biophys Res Commun. 2009;383:119-24 pubmed publisher
    Recent data has implicated the Ski protein as being a physiologically relevant negative regulator of signaling by retinoic acid (RA). The mechanism by which Ski represses RA signaling is unknown...
  83. Wang P, Chen Z, Meng Z, Fan J, Luo J, Liang W, et al. Dual role of Ski in pancreatic cancer cells: tumor-promoting versus metastasis-suppressive function. Carcinogenesis. 2009;30:1497-506 pubmed publisher
    b>Ski used to be defined as an oncogene that contributes to the resistance of tumor cells to transforming growth factor-beta (TGF-beta)-induced growth arrest...
  84. Ding B, Sun Y, Huang J. Overexpression of SKI oncoprotein leads to p53 degradation through regulation of MDM2 protein sumoylation. J Biol Chem. 2012;287:14621-30 pubmed publisher
    Protooncogene Ski was identified based on its ability to transform avian fibroblasts in vitro...
  85. Viglino D, Maignan M, Michalon A, Turk J, Buse S, Blancher M, et al. Survival of cardiac arrest patients on ski slopes: A 10-year analysis of the Northern French Alps Emergency Network. Resuscitation. 2017;119:43-47 pubmed publisher
    ..of pre-hospital management related to this challenging environment could be mitigated by the presence of ski-patrollers in ski areas and use of helicopters for medical rescue...
  86. Sun Y, Liu X, Eaton E, Lane W, Lodish H, Weinberg R. Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling. Mol Cell. 1999;4:499-509 pubmed
    ..These results demonstrate that Ski is a novel component of the TGF-beta signaling pathway and shed light on the mechanism of action of the Ski oncoprotein.
  87. Harada J, Kokura K, Kanei Ishii C, Nomura T, Khan M, Kim Y, et al. Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation. J Biol Chem. 2003;278:38998-9005 pubmed
    Multiple co-repressors such as N-CoR/SMRT, mSin3, and the c-ski proto-oncogene product (c-Ski) mediate the transcriptional repression induced by Mad and the thyroid hormone receptor by recruiting the histone deacetylase complex...
  88. Atanasoski S, Notterpek L, Lee H, Castagner F, Young P, Ehrengruber M, et al. The protooncogene Ski controls Schwann cell proliferation and myelination. Neuron. 2004;43:499-511 pubmed
    ..We define the protooncogene Ski, an inhibitor of TGF-beta signaling, as an essential component of the machinery that controls Schwann cell ..
  89. Jinnin M, Ihn H, Mimura Y, Asano Y, Tamaki K. Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts. Arthritis Rheum. 2007;56:1694-705 pubmed
    ..The aim of this study was to examine c-Ski and SnoN, principal molecules in the negative regulation of TGFbeta signaling, to further understand the autocrine ..
  90. Zhao H, Ueki N, Hayman M. The Ski protein negatively regulates Siah2-mediated HDAC3 degradation. Biochem Biophys Res Commun. 2010;399:623-8 pubmed publisher
    b>Ski acts as a transcriptional co-repressor by multiple direct and indirect interactions with several distinct repression complexes...
  91. Halsey C, Docherty M, McNeill M, Gilchrist D, Le Brocq M, Gibson B, et al. The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells. J Hematol Oncol. 2012;5:45 pubmed publisher
    ..terminal erythroid differentiation, with GATA1s expression characterised by lack of repression of MYB, CCND2 and SKI. These findings support the theory that the GATA1s isoform plays a role in the maintenance of proliferative ..
  92. Rashidian J, Le Scolan E, Ji X, Zhu Q, Mulvihill M, Nomura D, et al. Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. Sci Signal. 2015;8:ra14 pubmed publisher
    b>Ski, the transforming protein of the avian Sloan-Kettering retrovirus, inhibits transforming growth factor-β (TGF-β)/Smad signaling and displays both pro-oncogenic and anti-oncogenic activities in human cancer...