SIX1

Summary

Gene Symbol: SIX1
Description: SIX homeobox 1
Alias: BOS3, DFNA23, TIP39, homeobox protein SIX1, sine oculis homeobox homolog 1
Species: human

Top Publications

  1. doi Suppression of tumorigenesis and metastasis of hepatocellular carcinoma by shRNA interference targeting on homeoprotein Six1
    Kevin T P Ng
    Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Int J Cancer 127:859-72. 2010
  2. pmc Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition
    Chi Ming Li
    Institute for Cancer Genetics, Columbia University, New York, New York, USA
    Am J Pathol 160:2181-90. 2002
  3. pmc SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer
    Chu An Wang
    Program in Molecular Biology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    J Clin Invest 122:1895-906. 2012
  4. pmc Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations
    Aaron N Patrick
    Program in Molecular Biology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    J Biol Chem 284:20781-90. 2009
  5. ncbi The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins
    X Fan
    Departments of Pharmacology, Medicine and Pathology, and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 275:32129-34. 2000
  6. pmc Abrogation of the G2 cell cycle checkpoint associated with overexpression of HSIX1: a possible mechanism of breast carcinogenesis
    H L Ford
    Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 95:12608-13. 1998
  7. ncbi Expression and clinical implications of homeobox gene Six1 in cervical cancer cell lines and cervical epithelial tissues
    Xiu hui Zheng
    Department of Obstetrics and Gynecology, Daping Hospital, Third Military Medical University, Daping, Yuzhong District, Chongqing, China
    Int J Gynecol Cancer 20:1587-92. 2010
  8. doi Expression and significance of Six1 and Ezrin in cervical cancer tissue
    Jie Tan
    Department of Gynaecology, Jiangyin Hospital, Medical School of Southeast of China University, No 35 East of Renming Road, Jiangyin, 214400, China
    Tumour Biol 32:1241-7. 2011
  9. pmc Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition
    Erica L McCoy
    Program in Molecular Biology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Clin Invest 119:2663-77. 2009
  10. pmc Clinicopathological significance of homeoprotein Six1 in hepatocellular carcinoma
    K T Ng
    Centre for the Study of Liver Disease and Departments of Surgery, The University of Hong Kong, Queen Mary Hospital, L9 55, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, China
    Br J Cancer 95:1050-5. 2006

Scientific Experts

Detail Information

Publications168 found, 100 shown here

  1. doi Suppression of tumorigenesis and metastasis of hepatocellular carcinoma by shRNA interference targeting on homeoprotein Six1
    Kevin T P Ng
    Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Int J Cancer 127:859-72. 2010
    We previously demonstrated that the overexpression of homeoprotein Six1 in hepatocellular carcinoma (HCC) patients is associated with venous infiltration, advanced pathologic tumor metastasis (pTNM) stage and poor overall survival rate (..
  2. pmc Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition
    Chi Ming Li
    Institute for Cancer Genetics, Columbia University, New York, New York, USA
    Am J Pathol 160:2181-90. 2002
    ..are essential for cell survival and proliferation in early metanephric development, whereas others, including SIX1, MOX1, and SALL2, are predicted to act at this stage...
  3. pmc SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer
    Chu An Wang
    Program in Molecular Biology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    J Clin Invest 122:1895-906. 2012
    ..We therefore investigated whether SIX1, a homeodomain-containing transcription factor previously associated in breast cancer with lymph node positivity, ..
  4. pmc Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations
    Aaron N Patrick
    Program in Molecular Biology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    J Biol Chem 284:20781-90. 2009
    ..Recently, eight mutations in the SIX1 homeobox gene were discovered in BOR patients...
  5. ncbi The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins
    X Fan
    Departments of Pharmacology, Medicine and Pathology, and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 275:32129-34. 2000
    ..We show here a novel functional regulation of a co-activator directly by G protein subunits...
  6. pmc Abrogation of the G2 cell cycle checkpoint associated with overexpression of HSIX1: a possible mechanism of breast carcinogenesis
    H L Ford
    Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 95:12608-13. 1998
    ..These data support the role for homeobox genes in tumorigenesis/tumor progression, possibly through a cell cycle function...
  7. ncbi Expression and clinical implications of homeobox gene Six1 in cervical cancer cell lines and cervical epithelial tissues
    Xiu hui Zheng
    Department of Obstetrics and Gynecology, Daping Hospital, Third Military Medical University, Daping, Yuzhong District, Chongqing, China
    Int J Gynecol Cancer 20:1587-92. 2010
    The homeobox gene Six1 is overexpressed in multiple human tumors, playing a role in promoting tumorigenesis and metastasis. The present study was aimed to investigate the clinical implications of Six1 expression in cervical cancer.
  8. doi Expression and significance of Six1 and Ezrin in cervical cancer tissue
    Jie Tan
    Department of Gynaecology, Jiangyin Hospital, Medical School of Southeast of China University, No 35 East of Renming Road, Jiangyin, 214400, China
    Tumour Biol 32:1241-7. 2011
    This study aimed to investigate the expression of Six1 gene and its downstream target gene Ezrin in cervical cancer, and to correlate their expression to the clinical pathology of cervical cancer...
  9. pmc Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition
    Erica L McCoy
    Program in Molecular Biology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Clin Invest 119:2663-77. 2009
    b>Six1 is a developmentally regulated homeoprotein with limited expression in most normal adult tissues and frequent misexpression in a variety of malignancies...
  10. pmc Clinicopathological significance of homeoprotein Six1 in hepatocellular carcinoma
    K T Ng
    Centre for the Study of Liver Disease and Departments of Surgery, The University of Hong Kong, Queen Mary Hospital, L9 55, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, China
    Br J Cancer 95:1050-5. 2006
    ..The present study investigated the clinicopathological significance of a possible metastasis regulator Six1 in HCC patients who were undergone hepatectomy...
  11. pmc Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein
    Keiko Ikeda
    Department of Biology, Jichi Medical School, Yakushiji, Minamikawachi, Kawachi, Tochigi, 329 0498, Japan
    Mol Cell Biol 22:6759-66. 2002
    ..This work provides fundamental information on the role and the mechanism of action of this gene cassette in tissue differentiation and organogenesis...
  12. pmc The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1
    Ricardo D Coletta
    Department of Obstetrics and Gynecology, University Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 101:6478-83. 2004
    ..Here we show that the tissue-restricted cyclin A1 is a transcriptional target of the Six1 homeoprotein...
  13. doi MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers
    J S Imam
    Greehey Children s Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Oncogene 29:4971-9. 2010
    ..In this study, we investigate the mechanism by which the Six1 homeobox protein, which has a crucial role during development, is frequently deregulated in several poor outcome, ..
  14. doi Six1 overexpression in mammary cells induces genomic instability and is sufficient for malignant transformation
    Ricardo D Coletta
    Department of Obstretrics and Gynecology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    Cancer Res 68:2204-13. 2008
    ..During embryogenesis, the Six1 homeoprotein is essential for the expansion of precursor cell populations that give rise to muscle and kidney, ..
  15. pmc The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling
    Douglas S Micalizzi
    Program in Molecular Biology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Clin Invest 119:2678-90. 2009
    ..Here we show that overexpression of the homeoprotein Six1, normally a developmentally restricted transcriptional regulator, increases TGF-beta signaling in human breast ..
  16. pmc The role of Six1 in mammalian auditory system development
    Weiming Zheng
    McLaughlin Research Institute for Biomedical Sciences, 1520 23rd Street South, Great Falls, MT 59405, USA
    Development 130:3989-4000. 2003
    ..However, their roles during auditory system development have not been studied. We report that Six1 is required for mouse auditory system development...
  17. ncbi Transcriptional activation of the SALL1 by the human SIX1 homeodomain during kidney development
    Li Chai
    Department of Pathology, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:18918-26. 2006
    ..Consensus binding sites were identified for several transcription factors, with multiple sites for WT1 and SIX1. In transient transfection assays, SALL1 promoter activity was higher in HEK-293 human kidney cells and COS-7 ..
  18. doi SIX1 mutation screening in 247 branchio-oto-renal syndrome families: a recurrent missense mutation associated with BOR
    Amit Kochhar
    Doris Duke Clinical Research Fellowship, Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA
    Hum Mutat 29:565. 2008
    ..Both EYA1 and SIX1 are expressed in developing otic, branchial and renal tissue...
  19. ncbi Homeobox genes and connective tissue patterning
    G Oliver
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Development 121:693-705. 1995
    ..Six 1 and Six 2 also are expressed in skeletal and smooth muscle, respectively. These genes may participate in the patterning of the distal tendons of the limb phalanges by setting positional values along the limb axes...
  20. ncbi Cell cycle-regulated phosphorylation of the human SIX1 homeodomain protein
    H L Ford
    Division of Cancer Biology, Dana Farber Cancer Institute, the Department of Biological Chemistry and Molecular Pharmacology, and the Boston, Massachusetts 02115, USA
    J Biol Chem 275:22245-54. 2000
    Human SIX1 (HSIX1) is a member of the Six class of homeodomain proteins implicated in muscle, eye, head, and brain development...
  21. pmc SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes
    Rainer G Ruf
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 101:8090-5. 2004
    ..We recently mapped a locus for BOR/BO syndrome (BOS3) to human chromosome 14q23.1...
  22. pmc A comparative study of Eya1 and Eya4 protein function and its implication in branchio-oto-renal syndrome and DFNA10
    Yuzhou Zhang
    Molecular Otolaryngology Research Laboratories, University of Iowa, Iowa City, IA 52242, USA
    J Assoc Res Otolaryngol 5:295-304. 2004
    ..We verified that bait constructs of the homologous region ( Eya1HR and Eya4HR) interact with Six1 prey constructs, although no interaction with Dach1 prey was demonstrable...
  23. ncbi Development and differentiation of the ureteric bud into the ureter in the absence of a kidney collecting system
    Kevin T Bush
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, and Urological Diseases Research Center, Department of Urology, Children s Hospital, Boston, MA 02115, USA
    Dev Biol 298:571-84. 2006
    b>Six1-/- mice were found to have apparently normal ureters in the absence of a kidney, suggesting that the growth and development of the unbranched ureter is largely independent of the more proximal portions of the UB which differentiates ..
  24. pmc Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid
    Pin Xian Xu
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Development 129:3033-44. 2002
    ..These data indicate that Eya1 also regulates mature thyroid gland formation. Furthermore, we show that Six1 expression is markedly reduced in the arch mesenchyme, pouch endoderm and surface ectoderm in the pharyngeal region ..
  25. ncbi The BOS loci of Arabidopsis are required for resistance to Botrytis cinerea infection
    Paola Veronese
    Department of Botany and Plant Pathology, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    Plant J 40:558-74. 2004
    Three Botrytis-susceptible mutants bos2, bos3, and bos4 which define independent and novel genetic loci required for Arabidopsis resistance to Botrytis cinerea were isolated. The bos2 mutant is susceptible to B...
  26. ncbi Molecular evolution of the vertebrate mechanosensory cell and ear
    Bernd Fritzsch
    Creighton University, Dept of Biomedical Sciences, Omaha, NE 68178, USA
    Int J Dev Biol 51:663-78. 2007
    ..modified a genetic program through intercalation of genes between the master control genes on the top (Pax6, Eya1, Six1) of the hierarchy and the structural genes (rhodopsin) at the bottom, the as yet molecularly unknown mechanosensory ..
  27. pmc Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis
    Ricardo D Coletta
    Department of Obstetrics and Gynecology, University of Colorado Denver, Anschutz Medical Campus, 12800 E, 19th Ave, Aurora, CO 80045, USA
    BMC Dev Biol 10:4. 2010
    The Six1 homeobox gene is highly expressed in the embryonic mammary gland, continues to be expressed in early postnatal mammary development, but is lost when the mammary gland differentiates during pregnancy...
  28. ncbi Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo
    Raphaelle Grifone
    département génétique et développement, Institut Cochin Paris, INSERM, U567, Paris, F 75014 France
    Dev Biol 302:602-16. 2007
    In mammals, Pax3, Six4, Six1 and Six5 genes are co-expressed with Eya1, Eya2 and Eya4 genes during mouse somitogenesis...
  29. ncbi Identification and characterization of the zebrafish and fugu genes encoding tuberoinfundibular peptide 39
    Madhusudhan R Papasani
    Department of Biological Sciences, Illinois State University, Normal, Illinois 61790, USA
    Endocrinology 145:5294-304. 2004
    ..PTH2R) has been isolated from mammals and zebrafish, only its mammalian agonist, tuberoinfundibular peptide 39 (TIP39), has been characterized thus far...
  30. ncbi Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1
    Dan Zou
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Dev Biol 293:499-512. 2006
    ..Here, we examined their roles in pharyngeal pouch development. Six1-/- mice lack thymus and parathyroid and analysis of Six1-/- third pouch endoderm demonstrated that the patterning ..
  31. ncbi Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid hormone receptor family
    I A Hansen
    Department of Medicine Endocrinology, University of Wurzburg, Josef Schneider Strasse 2, Germany
    J Endocrinol 174:95-102. 2002
    The polypeptide TIP39 (tuberoinfundibular peptide of 39 residues) is a potent activator of the parathyroid hormone (PTH)-2 receptor (P2R) and an antagonist of the PTH-1 receptor (P1R)...
  32. pmc Evidence for the expression of parathyroid hormone 2 receptor in the human brainstem
    Attila G Bagó
    Neuromorphological and Neuroendocrine Research Laboratory, Department of Anatomy, Histology and Embryology, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary
    Ideggyogy Sz 61:123-6. 2008
    ..Initial functional studies suggest that the PTH2R is involved in the regulation of viscerosensory information processing. As a first step towards clinical applications, herein we describe the presence of the PTH2R in the human brainstem...
  33. pmc The non-conserved C-terminal segments of Sine Oculis Homeobox (SIX) proteins confer functional specificity
    Brandon P Weasner
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Genesis 47:514-23. 2009
    ..Members of this transcription factor family can be divided into three subgroups: Six1/2, Six4/5, and Six3/6...
  34. pmc Elevated amounts of myocilin in the aqueous humor of transgenic mice cause significant changes in ocular gene expression
    Walter Paper
    Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    Exp Eye Res 87:257-67. 2008
    ..Differences in expression were also found for Six1 which encodes for a transcription factor, and for Pftk1 whose gene product is a cdc2-related protein kinase...
  35. doi Expression of Six1 and Six4 in mouse taste buds
    Yuko Suzuki
    Division of Histology, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido, Ishikari Tobetsu 061 0293, Japan
    J Mol Histol 41:205-14. 2010
    ..We examined the expression of Six1 and Six4 mRNAs in mouse taste buds by using in situ hybridization...
  36. ncbi Branchio-oto-renal syndrome
    Amit Kochhar
    Molecular Otolaryngology Research Laboratories, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Med Genet A 143:1671-8. 2007
    ..the BOR phenotype have been identified and two genes that act in a regulatory network have been cloned, EYA1 and SIX1. EYA1 and SIX1 are homologous to genes involved in Drosophila eye development, eyes absent gene (eya), and sine ..
  37. ncbi Prevalence of mutations in renal developmental genes in children with renal hypodysplasia: results of the ESCAPE study
    Stefanie Weber
    Department of Pediatric Nephrology, Hopital Necker Enfants Malades, Universite Rene Descartes, 147 Rue de Sevres, 75015 Paris, France
    J Am Soc Nephrol 17:2864-70. 2006
    ..symptoms have been identified in TCF2 (renal cysts and diabetes syndrome), PAX2 (renal-coloboma syndrome), EYA1 and SIX1 (branchio-oto-renal syndrome), and SALL1 (Townes-Brocks syndrome)...
  38. ncbi Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme
    Deepali Pitre Poladia
    Center for Cell and Vascular Biology, Columbus Children s Research Institute, 700 Children s Drive, Columbus, OH 43205, USA
    Dev Biol 291:325-39. 2006
    ..By in situ hybridization, regions of mutant mesenchyme near the ureteric bud(s) express Eya1 and Six1, but not Six2, Sall1, or Pax2, while the ureteric bud expresses Ret and Pax2 normally...
  39. ncbi Molecular mechanisms of ligand recognition by parathyroid hormone 1 (PTH1) and PTH2 receptors
    S R Hoare
    Laboratory of Genetics, NIMH, Buidling 36 Rm 3D06, 36 Convent Drive MSC4090, Bethesda, MD 20892 4094, USA
    Curr Pharm Des 7:689-713. 2001
    ..and three related ligands (PTH, PTH-related protein (PTHrP) an d tuberoinfundibular peptide of 39 residues (TIP39))...
  40. pmc Catweasel mice: a novel role for Six1 in sensory patch development and a model for branchio-oto-renal syndrome
    Erika A Bosman
    The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Dev Biol 328:285-96. 2009
    ..We mapped the catweasel mutation to a critical region of 13 Mb on chromosome 12 containing the Six1, -4 and -6 genes...
  41. ncbi Six and Eya expression during human somitogenesis and MyoD gene family activation
    Francoise Fougerousse
    URA CNRS 1923, Genethon, 1 rue de l Internationale, BP60, 91002 Evry, France
    J Muscle Res Cell Motil 23:255-64. 2002
    ..b>Six1, Six4 and Six5 homeoproteins are detected later than Myf5 activation...
  42. ncbi Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear
    Dan Zou
    McLaughlin Research Institute for Biomedical Sciences, 1520 23rd Street South, MT 59405, USA
    Dev Biol 298:430-41. 2006
    ..However, it remains unknown whether Pax genes interact with Eya1 or Six1 during inner ear morphogenesis...
  43. pmc Distribution of tuberoinfundibular peptide of 39 residues and its receptor, parathyroid hormone 2 receptor, in the mouse brain
    Catherine A Faber
    Section on Fundamental Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892 4094, USA
    J Comp Neurol 502:563-83. 2007
    Tuberoinfundibular peptide of 39 residues (TIP39) was identified as a potent parathyroid hormone 2 receptor (PTH2R) agonist...
  44. ncbi Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies
    M E Gallardo
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Velazquez 144, Madrid, 28006, Spain
    Genomics 61:82-91. 1999
    ..Chromosomal mapping of SIX6 revealed that it is closely linked to SIX1 and SIX4 in human chromosome 14q22...
  45. pmc Dynamic expression of Six family genes in the dental mesenchyme and the epithelial ameloblast stem/progenitor cells during murine tooth development
    Koji Nonomura
    Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry, Sendai, Japan
    J Anat 216:80-91. 2010
    ..We found dynamic expression patterns for Six1, Six2, Six4 and Six5 in the oral epithelium and mesenchymal cells with distinct expression patterns at the early ..
  46. pmc Six1 is required for the early organogenesis of mammalian kidney
    Pin Xian Xu
    McLaughlin Research Institute, 1520 23rd Street South, Great Falls, MT 59405, USA
    Development 130:3085-94. 2003
    ..to Drosophila sine oculis (so) which encodes a homeodomain transcription factor, is composed of six members (Six1-6)...
  47. pmc Parathyroid hormone 2 receptor and its endogenous ligand tuberoinfundibular peptide of 39 residues are concentrated in endocrine, viscerosensory and auditory brain regions in macaque and human
    A G Bagó
    Neuromorphological and Neuroendocrine Research Laboratory, Department of Anatomy, Histology and Endocrinology, Semmelweis University and the Hungarian Academy of Sciences, Tuzolto u 58, Budapest H 1094, Hungary
    Neuroscience 162:128-47. 2009
    Parathyroid hormone receptor 2 (PTH2R) and its ligand, tuberoinfundibular peptide of 39 residues (TIP39) constitute a neuromodulator system implicated in endocrine and nociceptive regulation...
  48. pmc Cooperation between myogenic regulatory factors and SIX family transcription factors is important for myoblast differentiation
    Yubing Liu
    Ottawa Institute of Systems Biology and Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Faculty of Medicine, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada
    Nucleic Acids Res 38:6857-71. 2010
    ..We have conducted a functional genomic study of the role played by SIX1 and SIX4 during the differentiation of skeletal myoblasts, a model of adult muscle regeneration...
  49. pmc Six4, a putative myogenin gene regulator, is not essential for mouse embryonal development
    H Ozaki
    Departments of Biology, Jichi Medical School, Tochigi 329 0498, Japan
    Mol Cell Biol 21:3343-50. 2001
    ..The expression pattern was similar to that of Six1 except at the early stage of embryonic day 8.5...
  50. pmc Transcription factor SIX5 is mutated in patients with branchio-oto-renal syndrome
    Bethan E Hoskins
    Department of Pediatrics and of Human Genetics, University of Michigan, Ann Arbor, MI, USA
    Am J Hum Genet 80:800-4. 2007
    ..Mutations in EYA1 are known to cause BOR. More recently, mutations in SIX1, which interacts with EYA1, were identified as an additional cause of BOR...
  51. doi Making senses development of vertebrate cranial placodes
    Gerhard Schlosser
    Zoology, School of Natural Sciences and Martin Ryan Institute, National University of Ireland, Galway, Ireland
    Int Rev Cell Mol Biol 283:129-234. 2010
    ..evidence for the existence of a panplacodal primordium and discusses the central role of transcription factors Six1 and Eya1 in the regulation of processes shared between different placodes...
  52. pmc SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation
    Xuguang Nie
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
    Development 137:755-65. 2010
    ..b>Six1 is a crucial regulator of renal development: mutations in human SIX1 cause branchio-oto-renal (BOR) syndrome and ..
  53. doi Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4
    Binglai Chen
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine of NYU, New York, NY 10029, USA
    Dev Biol 326:75-85. 2009
    ..In mice, loss of Six1 affects OE morphogenesis but not placode formation...
  54. ncbi Neurons containing tuberoinfundibular peptide of 39 residues project to limbic, endocrine, auditory and spinal areas in rat
    A Dobolyi
    Laboratory of Genetics, National Institute of Mental Health, 36 Convent Drive, MSC4094, Building 36, Room 3D06, Bethesda, MD 20892 4094, USA
    Neuroscience 122:1093-105. 2003
    Accumulating evidence suggests that tuberoinfundibular peptide of 39 residues (TIP39) may be the endogenous ligand of the parathyroid hormone 2 receptor...
  55. pmc Tuberoinfundibular Peptide of 39 residues is required for germ cell development
    Ted B Usdin
    National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 149:4292-300. 2008
    Tuberoinfundibular peptide of 39 residues (TIP39) was identified as a PTH 2 receptor ligand. We report that mice with deletion of Tifp39, the gene encoding TIP39, are sterile...
  56. pmc Tuberoinfundibular peptide of 39 residues (TIP39) signaling modulates acute and tonic nociception
    Eugene L Dimitrov
    Section on Fundamental Neuroscience, National Institute of Mental Health, 35 Convent Drive, Room 1B 213, Bethesda, MD 20892, USA
    Exp Neurol 226:68-83. 2010
    Tuberoinfundibular peptide of 39 residues (TIP39) synthesizing neurons at the caudal border of the thalamus and in the lateral pons project to areas rich in its receptor, the parathyroid hormone 2 receptor (PTH2R)...
  57. doi The six family of homeobox genes in development and cancer
    Kimberly L Christensen
    Program in Molecular Biology, University of Colorado School of Medicine, Denver, Colorado, USA
    Adv Cancer Res 101:93-126. 2008
    ..In addition, aberrant expression of Six, Eya, and Dach occurs in numerous human tumors, and Six1, in particular, plays a causal role both in tumor initiation and in metastasis...
  58. ncbi Transcript expression of the tuberoinfundibular peptide (TIP)39/PTH2 receptor system and non-PTH1 receptor-mediated tonic effects of TIP39 and other PTH2 receptor ligands in renal vessels
    Anne Eichinger
    Renovascular Pharmacology and Physiology, National Institute of Health and Medical Research, University Louis Pasteur Medical School, 11 rue Humann, Bâtiment 4, F67085 Strasbourg Cedex, France
    Endocrinology 143:3036-43. 2002
    ..Moreover, results obtained in IPK desensitized to the vasodilatory action of PTHrP (1-36) strongly suggest that TIP, along with PTHrP, might be coordinately involved in the regulation of renal hemodynamics...
  59. doi Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR
    Shigeru Sato
    Division of Biology, Center for Molecular Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    Dev Biol 344:158-71. 2010
    ..all placodes originate from a common precursor domain, the pre-placodal region (PPR), marked by the expression of Six1/4 and Eya1/2...
  60. pmc The TIP39-PTH2 receptor system: unique peptidergic cell groups in the brainstem and their interactions with central regulatory mechanisms
    Arpad Dobolyi
    Department of Anatomy, Histology and Embryology, HAS Semmelweis University, Budapest, Hungary
    Prog Neurobiol 90:29-59. 2010
    Tuberoinfundibular peptide of 39 residues (TIP39) is the recently purified endogenous ligand of the previously orphan G-protein coupled parathyroid hormone 2 receptor (PTH2R)...
  61. pmc Acoustic stress activates tuberoinfundibular peptide of 39 residues neurons in the rat brain
    Miklos Palkovits
    Laboratory of Neuromorphology, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary
    Brain Struct Funct 214:15-23. 2009
    ..immunoreactivity (Fos-ir) was investigated in neurons that synthesize tuberoinfundibular peptide of 39 residues (TIP39) in the rat brain: in the subparafascicular area of the thalamus, the posterior intralaminar complex of the ..
  62. ncbi The parathyroid hormone 2 (PTH2) receptor
    T B Usdin
    Laboratory of Genetics, National Institute of Mental Health, Building 36 Room 3D06, 36 Convent Drive, Bethesda, Maryland 20892 4094, USA
    Receptors Channels 8:211-8. 2002
    ..activated at high potency by PTH and by the recently discovered peptide tuberoinfundibular peptide of 39 residues (TIP39)...
  63. ncbi Tuberoinfundibular peptide (7-39) [TIP(7-39)], a novel, selective, high-affinity antagonist for the parathyroid hormone-1 receptor with no detectable agonist activity
    S R Hoare
    Unit on Cell Biology, Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland, USA
    J Pharmacol Exp Ther 295:761-70. 2000
    ..tuberoinfundibular peptide (7-39) [TIP(7-39)], derived from the likely endogenous ligand for the PTH2 receptor TIP39. In this study its in vitro profile is evaluated and compared with that of [D-Trp(12),Tyr(34)]bPTH(7-34) and PTHrP(..
  64. pmc Tuberoinfundibular peptide of 39 residues modulates the mouse hypothalamic-pituitary-adrenal axis via paraventricular glutamatergic neurons
    Eugene Dimitrov
    Section on Fundamental Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Comp Neurol 518:4375-94. 2010
    ..area at the caudal border of the thalamus that contain the neuropeptide tuberoinfundibular peptide of 39 residues (TIP39) densely innervate several hypothalamic areas, including the paraventricular nucleus (PVN)...
  65. ncbi Sequential expression and redundancy of Pitx2 and Pitx3 genes during muscle development
    Aurore L'honoré
    Laboratoire de Genetique Moleculaire, Institut de recherches cliniques de Montreal IRCM, 110, avenue des Pins Ouest, Montreal, QC, Canada H2W 1R7
    Dev Biol 307:421-33. 2007
    ..including bHLH muscle regulatory factors (MRFs), the paired factors Pax3 and Pax7 and the homeobox factors Six1 and Six4. This program is critically dependent on MRFs that target downstream muscle-specific genes...
  66. ncbi Establishment of tendon-derived cell lines exhibiting pluripotent mesenchymal stem cell-like property
    R Salingcarnboriboon
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Exp Cell Res 287:289-300. 2003
    ..Tendon phenotype-related genes such as those encoding scleraxis, Six1, EphA4, COMP, and type I collagen were expressed in these tendon cell clones...
  67. ncbi The human tuftelin gene: cloning and characterization
    Z Mao
    Dental Research Unit, Department of Oral Biology, Institute of Dental Sciences, Hebrew University, Hadassah Faculty of Dental Medicine, Jerusalem, Israel
    Gene 279:181-96. 2001
    ..region, recently reported to be involved with tuftelin self-assembly and with the interaction of tuftelin with TIP39 (a novel tuftelin interacting protein)...
  68. pmc Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashion
    Gerhard Schlosser
    Brain Research Institute, University of Bremen, FB2, PO Box 330440, 28334 Bremen, Germany
    Dev Biol 320:199-214. 2008
    Genes of the Eya family and of the Six1/2 subfamily are expressed throughout development of vertebrate cranial placodes and are required for their differentiation into ganglia and sense organs...
  69. pmc Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site
    F Spitz
    Institut National de la Santé et de la Recherche Médicale U129, Institut Cochin de Genetique Moleculaire, Universite Rene Descartes Paris V, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    Proc Natl Acad Sci U S A 95:14220-5. 1998
    ..Antibodies directed specifically against Six1 or Six4 proteins reveal that each of these proteins is present in the embryo when myogenin is activated and ..
  70. ncbi Hypobranchial placodes in Xenopus laevis give rise to hypobranchial ganglia, a novel type of cranial ganglia
    Gerhard Schlosser
    Brain Research Institute, University of Bremen, FB 2, PO Box 33 04 40, 28334, Bremen, Germany
    Cell Tissue Res 312:21-9. 2003
    ..laevis is described in more detail using in situ hybridization and immunohistochemistry for various placodal ( Six1, Eya1) and neurogenic ( NGNR-1, NeuroD, Delta-1, Hu, acetylated tubulin) markers...
  71. pmc Persistently altered epigenetic marks in the mouse uterus after neonatal estrogen exposure
    Wendy N Jefferson
    National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, PO Box 12233, MD E4 05, Research Triangle Park, North Carolina 27709
    Mol Endocrinol 27:1666-77. 2013
    ..the locus-specific association of modified histones with 2 genes, lactoferrin (Ltf) and sine oculis homeobox 1 (Six1), which are permanently upregulated in adults after neonatal DES treatment...
  72. pmc Thalamic neuropeptide mediating the effects of nursing on lactation and maternal motivation
    Melinda Cservenák
    Laboratory of Neuromorphology, Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest 1094, Hungary Research Group of Molecular and Systems Neurobiology, The Hungarian Academy of Sciences, Budapest 1051, Hungary
    Psychoneuroendocrinology 38:3070-84. 2013
    ..Tuberoinfundibular peptide of 39 residues (TIP39) may contribute to its effects on prolactin release and maternal motivation...
  73. ncbi Genetic determination of nephrogenesis: the Pax/Eya/Six gene network
    Stephan Brodbeck
    Pediatr Nephrol 19:249-55. 2004
    ..Many of the genes that play a crucial role in early kidney development, such as Pax2, Eya1, Six1, Six2, Sall1, Foxc1, Wt1, and the Hox11 genes, are expressed in the mesenchyme and encode transcription factors ..
  74. ncbi The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis
    Yanlin Yu
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892 4264, USA
    Cancer Res 66:1982-9. 2006
    ..We have shown that the homeodomain transcription factor Six1, known to be required for normal development of migratory myogenic progenitor cells, is sufficient to promote ..
  75. doi Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development
    Yuka Fujimoto
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    Dev Cell 26:416-30. 2013
    ..Here, we report that the transcription factors Six1 and Six4 are required for male gonadal differentiation...
  76. ncbi Colobomatous macrophthalmia with microcornea syndrome maps to the 2p23-p16 region
    Nursel H Elcioglu
    Genetic Disorders Unit, Department of Pediatrics, Marmara University Medical Faculty, Istanbul, Turkey
    Am J Med Genet A 143:1308-12. 2007
    ..Subsequently, the chromosome 14q24 region containing the CHX10, SIX1, and SIX4 genes were also excluded...
  77. doi HPPD: A newly recognized autosomal dominant disorder involving hypertelorism, preauricular sinus, punctal pits, and deafness mapping to chromosome 14q31
    Srirangan Sampath
    Department of Genetics, LSU Health Sciences Center, New Orleans, Louisiana, USA
    Am J Med Genet A 155:976-85. 2011
    ..We ruled out the involvement of EYA1, SIX1, and SIX5 as candidate genes by direct sequencing of their exons and by SNP-based linkage analysis...
  78. doi Novel potential regulators of maternal adaptations during lactation: tuberoinfundibular peptide 39 and amylin
    A Dobolyi
    Department of Anatomy, Histology and Embryology, Neuromorphological and Neuroendocrine Research Laboratory, Semmelweis University and Hungarian Academy of Sciences, Budapest, Hungary
    J Neuroendocrinol 23:1002-8. 2011
    ..in these adaptations, and we focus on two of them in the present study: tuberoinfundibular peptide of 39 residues (TIP39) and amylin...
  79. ncbi Early specification of limb muscle precursor cells by the homeobox gene Lbx1h
    K Schafer
    Institute of Physiological Chemistry, Martin Luther University Halle, 06097 Halle, Hollystr 1, Germany
    Nat Genet 23:213-6. 1999
    ..6) and those encoded by homeobox-containing genes, including c-Met (ref. 6), Tbx1 (ref. 7), Mox2 (ref. 8), Six1 and Six2 (ref. 9), Pitx2, Pax3 (refs 10,11) and Lbx1h (refs 12,13), are expressed in migrating limb precursor cells...
  80. pmc Notch2 is required for maintaining sustentacular cell function in the adult mouse main olfactory epithelium
    Steve Rodriguez
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Dev Biol 314:40-58. 2008
    ..In the absence of Notch2, the laminar nature of these glial-like cells is disrupted. Hes1, Hey1, and Six1, which are downstream effectors of the Notch pathway, are down-regulated, and cytochrome P450 and Glutathione S-..
  81. doi How to make a teleost adenohypophysis: molecular pathways of pituitary development in zebrafish
    Hans Martin Pogoda
    Institute for Developmental Biology, University of Cologne, Gyrhofstr 17, D 50931 Cologne, Germany
    Mol Cell Endocrinol 312:2-13. 2009
    ..most recent findings, including some thus far unpublished data from our own laboratory on the transcription factor Six1. In addition, zebrafish data will be discussed in comparison with current understanding of adenohypophysis ..
  82. pmc A novel chromosome 19p13.12 deletion in a child with multiple congenital anomalies
    Daniel R Jensen
    Division of Pediatric Otolaryngology, Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan 48109 5241, USA
    Am J Med Genet A 149:396-402. 2009
    ..Mutation analysis of EYA1, SIX1, and SIX5, genes that underlie otofaciocervical and/or branchio-oto-renal syndrome, was negative...
  83. pmc The medial paralemniscal nucleus and its afferent neuronal connections in rat
    Tamas Varga
    Neuromorphological and Neuroendocrine Research Laboratory, Department of Anatomy, Histology and Embryology, Semmelweis University and the Hungarian Academy of Sciences, Budapest, Hungary
    J Comp Neurol 511:221-37. 2008
    Previously, we described a cell group expressing tuberoinfundibular peptide of 39 residues (TIP39) in the lateral pontomesencephalic tegmentum, and referred to it as the medial paralemniscal nucleus (MPL)...
  84. pmc Defining a role for the homeoprotein Six1 in EMT and mammary tumorigenesis
    Derek C Radisky
    Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Clin Invest 119:2528-31. 2009
    ..In this issue of the JCI, McCoy and colleagues show that transgenic mice that express the homeoprotein Six1 in mammary epithelial cells show increases in stem/progenitor cell populations and subsequent tumor development, ..
  85. ncbi How is myogenesis initiated in chordates?
    Leokadia Kiełbówna
    Department of Animal Developmental Biology, Institute of Experimental Biology, University of Wrocław, Sienkiewicza 21, 50 335 Wrocław, Poland
    Folia Biol (Krakow) 60:107-19. 2012
    ..Cells migrating to the limb bud contain regulatory proteins Six4/Six1, Pax3, Lbx1 and c-met. Rectus abdominis develops from cells that contain Pax3 and Lbx1.
  86. pmc Renal hypodysplasia associates with a WNT4 variant that causes aberrant canonical WNT signaling
    Asaf Vivante
    Department of Pediatrics, Talpiot Medical Leadership Program, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Am Soc Nephrol 24:550-8. 2013
    ..RHD and screened for mutations in candidate genes involved in kidney development, including PAX2, HNF1B, EYA1, SIX1, SIX2, SALL1, GDNF, WNT4, and WT1...
  87. doi Identification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity
    Aaron B Krueger
    Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, USA
    J Biomol Screen 18:85-96. 2013
    ..The phosphatase activity of Eya is important for a subset of Six1-mediated transcription, making this a unique type of transcriptional control...
  88. pmc Development temperature has persistent effects on muscle growth responses in gilthead sea bream
    Daniel García de la serrana
    Physiological and Evolutionary Genomics Laboratory, Scottish Oceans Institute, School of Biology, University of St Andrews, St Andrews, Scotland, UK
    PLoS ONE 7:e51884. 2012
    ..Fasting was associated with a 20-fold increase in MAFbx, and a 5-fold increase in Six1 and WASp expression, which returned to NSF levels within 16h of SF...
  89. pmc A novel autosomal recessive non-syndromic deafness locus (DFNB35) maps to 14q24.1-14q24.3 in large consanguineous kindred from Pakistan
    Muhammad Ansar
    Department of Biological Sciences, Quaid i Azam University Islamabad, Pakistan
    Eur J Hum Genet 11:77-80. 2003
    ..75 cM spanning between markers D14S588 and D14S59. A maximum two-point LOD score of 5.3 and multipoint LOD score of 7.6 was obtained at marker D14S53. The interval for DFNB35 does not overlap with the regions for DFNA9, DFNA23 or DFNB5.
  90. ncbi Elevated expression and potential roles of human Sp5, a member of Sp transcription factor family, in human cancers
    Yongxin Chen
    Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, 4 6 1 Komaba, Meguro ku, Tokyo, Japan
    Biochem Biophys Res Commun 340:758-66. 2006
    ..CDC25C, CEACAM6, TMPRSS2, XBP1, MYBL1, ABHD2, and CXCL12) and Wnt/beta-Catenin signaling pathways (BAMBI, SIX1, IGFBP5, AES, and p21WAF1)...
  91. pmc Branchio-Oto-Renal Syndrome (BOR) associated with focal glomerulosclerosis in a patient with a novel EYA1 splice site mutation
    Maddalena Gigante
    Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy
    BMC Nephrol 14:60. 2013
    ..gene mutated in BOR patients is EYA1, the human homolog of the Drosophila eyes absent gene, while mutations in SIX1 gene, the human homolog of sine oculis, encoding a DNA binding protein interacting with EYA1, have been reported ..
  92. pmc Embryonic origin and remodeling of the urinary and digestive outlets
    Chen Wang
    Department of Urology, Boston Children s Hospital, Boston, Massachusetts, USA
    PLoS ONE 8:e55587. 2013
    ..We demonstrate that Six1 and Six2 are complementarily but asymmetrically expressed in the PCM progenitors...
  93. pmc Mesodermal gene expression in the acoel Isodiametra pulchra indicates a low number of mesodermal cell types and the endomesodermal origin of the gonads
    Marta Chiodin
    Departament de Genetica, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 8:e55499. 2013
    ..mesodermal cell types we describe the expression pattern of 12 orthologs of bilaterian mesodermal markers including Six1/2, Twist, FoxC, GATA4/5/6, in the acoel Isodiametra pulchra...
  94. ncbi Tuberoinfundibular peptide of 39 residues: a new mediator of cardiac function via nitric oxide production in the rat heart
    G Ross
    Institute of Physiology, Justus Liebig University, Giessen, Germany
    Endocrinology 146:2221-8. 2005
    Tuberoinfundibular peptide (TIP39) was initially identified as a neurotransmitter and agonist of the PTH2 receptor, which is expressed in the cardiovascular system...
  95. ncbi Six1 is not involved in limb tendon development, but is expressed in limb connective tissue under Shh regulation
    Marie Ange Bonnin
    Biologie du Développement, CNRS UMR 7622, Universite P et M Curie, 9 quai Saint Bernard, Bat C, 6 e E, Case 24, Paris Cedex 05 75252, France
    Mech Dev 122:573-85. 2005
    Mice deficient for the homeobox gene Six1 display defects in limb muscles consistent with the Six1 expression in myogenic cells...
  96. doi EYA1-SIX1 complex in neurosensory cell fate induction in the mammalian inner ear
    Elaine Y M Wong
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hear Res 297:13-9. 2013
    The phosphatase-transactivator EYA1 interacts with the homeodomain protein SIX1 to form transcriptional activation complexes, which play essential roles in regulating cell proliferation, survival and induction of sensory and neuronal ..
  97. pmc Six1 regulates MyoD expression in adult muscle progenitor cells
    Yubing Liu
    Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 8:e67762. 2013
    ..We show that Six1, a transcription factor essential for embryonic myogenesis, also regulates MyoD expression in muscle progenitor ..
  98. doi Upregulation of notch2 and six1 is associated with progression of early-stage lung adenocarcinoma and a more aggressive phenotype at advanced stages
    Takahiro Mimae
    Surgical Oncology, Division of Genome Radiobiology and Medicine, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Clin Cancer Res 18:945-55. 2012
    ..This study investigates how transcriptional aberrations in adenocarcinoma cells at the early stage define the clinical phenotypes of adenocarcinoma tumors at the advanced stage...
  99. doi Mutation screening of the EYA1, SIX1, and SIX5 genes in an East Asian cohort with branchio-oto-renal syndrome
    Shih Hao Wang
    Department of Otolaryngology, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan
    Laryngoscope 122:1130-6. 2012
    ..To explore the genetic characteristics of branchio-oto-renal (BOR) syndrome in an East Asian population...
  100. pmc Six homeoproteins directly activate Myod expression in the gene regulatory networks that control early myogenesis
    Frederic Relaix
    UPMC Paris 06, UMR S 787, Paris, France
    PLoS Genet 9:e1003425. 2013
    ..At the axial level, we further show that Myod is still expressed in compound Six1/Six4:Pax3 but not in Six1/Six4:Myf5 triple mutant embryos, demonstrating that Six1/4 participates in the Pax3-Myod ..
  101. ncbi Induction and specification of cranial placodes
    Gerhard Schlosser
    Brain Research Institute, AG Roth, University of Bremen, FB2, 28334 Bremen, Germany
    Dev Biol 294:303-51. 2006
    ..This common primordium is defined by the expression of transcription factors of the Six1/2, Six4/5, and Eya families, which later continue to be expressed in all placodes and appear to promote generic ..

Research Grants66

  1. Roles of transcription factors in kidney development
    Pin Xian Xu; Fiscal Year: 2010
    ..The long-term objective of this proposal is to elucidate the mechanisms by which Eya1 and Six1 control normal kidney development...
  2. The Role of Eya and its Interacting Gene Six in Inner Ear Development
    Pin Xian Xu; Fiscal Year: 2009
    ..is to investigate the intrinsic programs of sensory progenitors, focusing on the evolutionarily conserved Eya1-Six1 transcription complex, which is critical for normal sensory organ formation in the inner ear, via gain-of-function ..
  3. Structural Biology of Class B G-Protein Coupled Receptors
    H Eric Xu; Fiscal Year: 2010
    ..Our specific aims are focused on structural determination of the ECD of PTH1R and PTH2R bound to PTH, PTHrP, and TIP39. After structural determination, we will scrutinize and analyze the structures for key structural elements, and we ..
  4. Cellular and Molecular Mechanisms of Otic Placode Induction
    Andrew K Groves; Fiscal Year: 2010
    ..by the presence of a functional FGF signaling pathway, or by the expression of transcription factors such as Six1, Eya2, Dachl or FoxiS in pre-placodal ectoderm...
  5. Cellular and Molecular Mechanisms of Otic Placode Induction
    Andrew Groves; Fiscal Year: 2009
    ..by the presence of a functional FGF signaling pathway, or by the expression of transcription factors such as Six1, Eya2, Dachl or FoxiS in pre-placodal ectoderm...
  6. Identification of Nonsyndromic Hearing Impairment Genes
    Suzanne Leal; Fiscal Year: 2009
    ..This study has also identified a number of novel loci (DFNA23, DFNA24, DFNB35, DFNB38, DFNB39, DFNB42, DFNB43, DFNB44 and DFNB45) for which the genes are currently unknown...
  7. HOMEOBOX GENE SIX3 IN EYE DEVELOPMENT
    Guillermo Oliver; Fiscal Year: 2005
    A few years ago, three novel murine homeobox genes (Six1, Six2, and Six3) closely related to the Drosophila sine oculis (so) gene were isolated; all are included in the Six/so gene family...
  8. Retinal Cell-Fate Determination and Pattern Formation
    Graeme Mardon; Fiscal Year: 2010
    ..In humans, mutations in EYA1 and SIX1 cause the autosomal dominant disorder known as BOR (branchio-oto-renal) syndrome, characterized by branchial arch ..
  9. Identifying new genes for branchio-oto-renal syndrome
    Friedhelm Hildebrandt; Fiscal Year: 2009
    ..total genome search for linkage in a large kindred of 18 individuals affected with BO, we mapped a new gene locus (BOS3) to chromosome 14q21...
  10. Altered expression of PTH type-2 receptor and TIP39
    David Rubin; Fiscal Year: 2005
    Tuberoinfundibular peptide 39 (TIP39) and Parathyroid Hormone (PTH) type-2 receptor (PTH2R) constitute a new endocrine system with conserved neuronal mRNA expression in zebrafish and mouse brain...
  11. The Role of the Eyal Gene in Metanephric Induction
    Richard Maas; Fiscal Year: 2006
    ..In addition, we will use other mouse kidney mutants lacking Six1, Wtl, c-ret, Gdnf, ld (Fmnl) and Pax2 to assay dependencies of gene expression in metanephric mesenchyme and ..
  12. The Role of the Eyal Gene in Metanephric Induction
    Richard Maas; Fiscal Year: 2007
    ..In addition, we will use other mouse kidney mutants lacking Six1, Wtl, c-ret, Gdnf, ld (Fmnl) and Pax2 to assay dependencies of gene expression in metanephric mesenchyme and ..
  13. The Role of the Eyal Gene in Metanephric Induction
    Richard Maas; Fiscal Year: 2003
    ..In addition, we will use other mouse kidney mutants lacking Six1, Wtl, c-ret, Gdnf, ld (Fmnl) and Pax2 to assay dependencies of gene expression in metanephric mesenchyme and ..
  14. The Role of Eya and its Interacting Gene Six in Mammalian Inner Ear Development
    Pin Xian Xu; Fiscal Year: 2010
    ..We identified mutations in the human SIX1 or SIX5 from BOR patients and analyzed these mutations functionally, identified the developmental functions of Six1 ..
  15. The Role of Eya and its Interacting Gene Six in Mammalian Inner Ear Development
    Pin Xian Xu; Fiscal Year: 2007
    ..We identified mutations in the human SIX1 or SIX5 from BOR patients and analyzed these mutations functionally, identified the developmental functions of Six1 ..
  16. The Role of Eya and its Interacting Gene Six in Mammalian Inner Ear Development
    Pin Xian Xu; Fiscal Year: 2009
    ..We identified mutations in the human SIX1 or SIX5 from BOR patients and analyzed these mutations functionally, identified the developmental functions of Six1 ..
  17. Eya1 and its Interacting Genes in Inner Ear Development
    Pin Xian Xu; Fiscal Year: 2006
    ..Molecularly, Six1 but not Pax2 and Pax8 expression in the otic vesicle depends upon Eya1 function...
  18. Proliferation Control of Neuroendo/Renal Organogenesis
    Xue Li; Fiscal Year: 2005
    ..Functional importance of Six-family genes in tumorigenesis is further suggested by the observations that Six1 is selectively up regulated at the late stage of G1 cell cycle and promotes G2/S cell cycle transition...
  19. Regulation of the PTH/PTHrP type-2 receptor and TIP39
    David Rubin; Fiscal Year: 2002
    ..It therefore appears that TIP39 is the endogenous ligand of the vertebrate PTH2R...
  20. G Protein Receptor--Structural Characterization
    Dale Mierke; Fiscal Year: 2006
    ..to utilize the establishment of the pharmacophore for the PTH1 receptor, as well as structural characterization of TIP39 (tuberoinfundibular peptide-39) to develop a structure-activity relationship for the PTH2 receptor...
  21. Role of Six1 in EMT and Tumor Progression
    Heide L Ford; Fiscal Year: 2010
    ..Transcribed by one such gene, the homeobox protein and transcription factor Six1 is expressed during embryogenesis where it mediates the proliferation and survival of progenitor cells...
  22. Role of Six1 in EMT and Tumor Progression
    Heide Ford; Fiscal Year: 2009
    ..Transcribed by one such gene, the homeobox protein and transcription factor Six1 is expressed during embryogenesis where it mediates the proliferation and survival of progenitor cells...
  23. Role of Six1 in EMT and Tumor Progression
    Heide Ford; Fiscal Year: 2007
    ..Transcribed by one such gene, the homeobox protein and transcription factor Six1 is expressed during embryogenesis where it mediates the proliferation and survival of progenitor cells...
  24. TRAIL Receptor Signaling in Human Tumors
    ANDREW M contact THORBURN; Fiscal Year: 2010
    ..can become selectively resistant to TRAIL is through the increased expression of the homeobox transcription factor Six1. We found that increased Six1 is common, occurring in >60% of metastatic ovarian cancers and 90% of metastatic ..
  25. TRAIL Receptor Signaling in Human Tumors
    Andrew Thorburn; Fiscal Year: 2009
    ..can become selectively resistant to TRAIL is through the increased expression of the homeobox transcription factor Six1. We found that increased Six1 is common, occurring in >60% of metastatic ovarian cancers and 90% of metastatic ..
  26. HSIX1 in cell cycle control and tumorigenesis
    Heide Ford; Fiscal Year: 2007
    ..Transcribed by one such gene, the homeobox protein and transcription factor Six1 is expressed during embryogenesis where it mediates the proliferation and survival of progenitor cells...
  27. Transcription Factors in Early Kidney Development
    Pin Xian Xu; Fiscal Year: 2007
    ..development by examining the role of the transcriptional coactivator Eya1, its interacting homeodomain protein Six1 and their cofactors...
  28. PTH Receptors in Vascular Smooth Muscle Cells
    Alessandro Bisello; Fiscal Year: 2007
    ..PTH, PTH-related protein (PTHrP), and TIP39 affect vascular tone...