SIRT7

Summary

Gene Symbol: SIRT7
Description: sirtuin 7
Alias: SIR2L7, NAD-dependent protein deacetylase sirtuin-7, NAD-dependent deacetylase sirtuin-7, SIR2-like protein 7, regulatory protein SIR2 homolog 7, silent mating type information regulation 2, S.cerevisiae, homolog 7, sir2-related protein type 7, sirtuin type 7
Species: human
Products:     SIRT7

Top Publications

  1. Michishita E, Park J, Burneskis J, Barrett J, Horikawa I. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell. 2005;16:4623-35 pubmed
    ..This study examines seven human proteins homologous to Sir2 (SIRT1 through SIRT7) for cellular localization, expression profiles, protein deacetylation activity, and effects on human cell ..
  2. de Nigris F, Cerutti J, Morelli C, Califano D, Chiariotti L, Viglietto G, et al. Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues. Br J Cancer. 2002;86:917-23 pubmed
    ..The human SIR-T8 protein has a molecular weight of 39 kDa and is primarily located in the cytoplasm under the nuclear membrane. The SIR-T8 gene is located on chromosome 17q25-1. ..
  3. Frye R. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun. 2000;273:793-8 pubmed
    Sirtuins (Sir2-like proteins) are present in prokaryotes and eukaryotes. Here, two new human sirtuins (SIRT6 and SIRT7) are found to be similar to a particular subset of insect, nematode, plant, and protozoan sirtuins...
  4. Ford E, Voit R, Liszt G, Magin C, Grummt I, Guarente L. Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev. 2006;20:1075-80 pubmed
    We investigated the role of SIRT7, one of the seven members of the mammalian sirtuin family...
  5. Ashraf N, Zino S, MacIntyre A, Kingsmore D, Payne A, George W, et al. Altered sirtuin expression is associated with node-positive breast cancer. Br J Cancer. 2006;95:1056-61 pubmed
    ..Levels of SIRT7 expression were significantly increased in breast cancer (P<0.0001)...
  6. Matsushima S, Sadoshima J. The role of sirtuins in cardiac disease. Am J Physiol Heart Circ Physiol. 2015;309:H1375-89 pubmed publisher
    ..Sirt6 has also recently been demonstrated to attenuate cardiac hypertrophy, and Sirt7 is known to regulate apoptosis and stress responses in the heart...
  7. Chun P. Role of sirtuins in chronic obstructive pulmonary disease. Arch Pharm Res. 2015;38:1-10 pubmed publisher
    ..Among the seven mammalian sirtuins, SIRT1-SIRT7, SIRT1 and SIRT6 are considered to have protective effects against COPD...
  8. Tanabe K, Liu J, Kato D, Kurumizaka H, Yamatsugu K, Kanai M, et al. LC-MS/MS-based quantitative study of the acyl group- and site-selectivity of human sirtuins to acylated nucleosomes. Sci Rep. 2018;8:2656 pubmed publisher
    ..Furthermore, we found Sirt7 to be a robust deacylase of H3K36/37, and its activity reliant on nucleosome-binding at its C-terminal basic ..
  9. Grande I, Amorim P, Freire A, Jallad R, Musolino N, Cescato V, et al. Differential gene expression of sirtuins between somatotropinomas and nonfunctioning pituitary adenomas. Pituitary. 2018;21:355-361 pubmed publisher
    ..4 and 40.5%, respectively, P < 0.01) as well as SIRT4 and SIRT7. Despite the lack of association between sirtuins and invasiveness or Ki-67 index, SIRT1 and SIRT3 expressions ..

More Information

Publications134 found, 100 shown here

  1. Zhu S, Dong Z, Ke X, Hou J, Zhao E, Zhang K, et al. the Role of Sirtuins Family in Cell Metabolism during Tumor Development. Semin Cancer Biol. 2018;: pubmed publisher
    ..As a family of NAD+ dependent protein modifying enzyme, sirtuins (SIRT1-SIRT7) have multiple catalytic functions such as deacetylase, desuccinylase, demalonylase, demyristoylase depalmitoylase,..
  2. Drew J, Farquharson A, Horgan G, Williams L. Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding. J Nutr Biochem. 2016;37:20-29 pubmed publisher
    ..Regulation of the SIRT/NAD system was associated with early (SIRT4, SIRT7, NAPRT1 and NMNAT2) and late phases (NMNAT3, NMRK2, ABCA1 and CD38) of glucose intolerance...
  3. Wang Y, He J, Liao M, Hu M, Li W, Ouyang H, et al. An overview of Sirtuins as potential therapeutic target: Structure, function and modulators. Eur J Med Chem. 2019;161:48-77 pubmed publisher
    ..family, which is widely distributed throughout the nature, has been divided into seven human isoforms (Sirt1-Sirt7)...
  4. Baur J, Ungvari Z, Minor R, Le Couteur D, De Cabo R. Are sirtuins viable targets for improving healthspan and lifespan?. Nat Rev Drug Discov. 2012;11:443-61 pubmed publisher
    ..Studies have implicated the sirtuins (SIRT1-SIRT7) as mediators of key effects of caloric restriction during ageing...
  5. Dass R, Sarshad A, Carson B, Feenstra J, Kaur A, Obrdlik A, et al. Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I. PLoS Genet. 2016;12:e1006217 pubmed publisher
    ..Upon DVL1 binding, the Pol I transcription activator and deacetylase Sirtuin 7 (SIRT7) releases from rDNA loci, concomitant with disassembly of Pol I transcription machinery at the rDNA promoter...
  6. Smestad J, Erber L, Chen Y, Maher L. Chromatin Succinylation Correlates with Active Gene Expression and Is Perturbed by Defective TCA Cycle Metabolism. iScience. 2018;2:63-75 pubmed publisher
    ..agents, consistent with previously reported chromatin hypersuccinylation effects observed in the context of SIRT7 depletion...
  7. Das A, Huang G, Bonkowski M, Longchamp A, Li C, Schultz M, et al. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 2018;173:74-89.e20 pubmed publisher
    ..NAD precursors reverse aspects of aging, in part, by activating sirtuin deacylases (SIRT1-SIRT7) that mediate the benefits of exercise and dietary restriction (DR)...
  8. Talakatta G, Sarikhani M, Muhamed J, Dhanya K, Somashekar B, Mahesh P, et al. Diabetes induces fibrotic changes in the lung through the activation of TGF-? signaling pathways. Sci Rep. 2018;8:11920 pubmed publisher
    ..diabetic cells to high glucose concentrations (25?mM) promoted the upregulation of caveolin-1, N-cadherin, SIRT3, SIRT7 and lactate levels, suggesting that long-term diabetes may promote cell proliferation...
  9. Ji S, Doucette J, Nazarali A. Protocols for Cloning, Expression, and Functional Analysis of Sirtuin2 (SIRT2). Methods Mol Biol. 2016;1436:189-99 pubmed publisher
    ..is a NAD(+)-dependent deacetylase that belongs to the sirtuin family, which is comprised of seven members (SIRT1-SIRT7) in humans. Furthermore, recent study shows that the Sirt2 gene has three transcript variants in mice...
  10. Zhang J, Choudhury M. The plasticizer BBP selectively inhibits epigenetic regulator sirtuin during differentiation of C3H10T1/2 stem cell line. Toxicol In Vitro. 2017;39:75-83 pubmed publisher
    ..Sirt1 gene expression was also significantly decreased at day 2, 4, 6, and 8 (p<0.05). However, Sirt7 gene expression was decreased only at day 2 and 8 (p<0...
  11. Sun M, Zhai M, Zhang N, Wang R, Liang H, Han Q, et al. MicroRNA-148b-3p is involved in regulating hypoxia/reoxygenation-induced injury of cardiomyocytes in vitro through modulating SIRT7/p53 signaling. Chem Biol Interact. 2018;296:211-219 pubmed publisher
    ..Bioinformatics analysis predicted that Sirtuin7 (SIRT7), a critical stress survival gene of cardiomyocytes, was a potential target gene of miR-148b-3p, which was then ..
  12. Kokkonen P, Kokkola T, Suuronen T, Poso A, Jarho E, Lahtela Kakkonen M. Virtual screening approach of sirtuin inhibitors results in two new scaffolds. Eur J Pharm Sci. 2015;76:27-32 pubmed publisher
    Sirtuins (SIRT1-SIRT7) are NAD dependent deacetylases and intriguing drug targets in for example neurodegenerative diseases and cancer...
  13. Gong J, Wang H, Lou W, Wang G, Tao H, Wen H, et al. Associations of sirtuins with clinicopathological parameters and prognosis in non-small cell lung cancer. Cancer Manag Res. 2018;10:3341-3356 pubmed publisher
    ..Our results suggested SIRT1, SIRT3, SIRT4, and SIRT7 were highly expressed in adeno-carcinoma (ADC) patients and female patients while SIRT5 were highly expressed in ..
  14. Yan W, Liang Y, Zhang Q, Wang D, Lei M, Qu J, et al. Arginine methylation of SIRT7 couples glucose sensing with mitochondria biogenesis. EMBO Rep. 2018;19: pubmed publisher
    ..b>SIRT7, a histone H3K18-specific deacetylase, epigenetically controls mitochondria biogenesis, ribosomal biosynthesis, ..
  15. Qi H, Shi X, Yu M, Liu B, Liu M, Song S, et al. Sirtuin 7-mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity. J Biol Chem. 2018;293:17769-17779 pubmed publisher
    ..Here, we report that sirtuin 7 (SIRT7) directly deacetylates WDR77 and that this deacetylation interferes with the WDR77-PRMT5 interaction and ..
  16. Kim J, Kim D, Cho S, Jung K, Kim J, Lee J, et al. Identification of a novel SIRT7 inhibitor as anticancer drug candidate. Biochem Biophys Res Commun. 2019;508:451-457 pubmed publisher
    ..b>SIRT7 is localized in the nucleolus...
  17. Jiang Y, Han Z, Wang Y, Hao W. Depletion of SIRT7 sensitizes human non-small cell lung cancer cells to gemcitabine therapy by inhibiting autophagy. Biochem Biophys Res Commun. 2018;506:266-271 pubmed publisher
    ..In our study, we find that SIRT7 protein level elevated dramatically in response to an anti-metabolic drug-gemcitabine treatment...
  18. Ryu D, Jo Y, Lo Sasso G, Stein S, Zhang H, Perino A, et al. A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function. Cell Metab. 2014;20:856-69 pubmed publisher
    Mitochondrial activity is controlled by proteins encoded by both nuclear and mitochondrial DNA. Here, we identify Sirt7 as a crucial regulator of mitochondrial homeostasis...
  19. Khojah S, Payne A, McGuinness D, Shiels P. Segmental Aging Underlies the Development of a Parkinson Phenotype in the AS/AGU Rat. Cells. 2016;5: pubmed
    ..We have used biomarkers of aging (SA ?-Gal, p16Ink4a, Sirt5, Sirt6, and Sirt7) to demonstrate the presence of an accelerated aging phenotype across different brain regions in the AS/AGU rat, a ..
  20. Moghadam F, Mesbah Ardakani M, Nasr Esfahani M. Ferulic Acid exerts concentration-dependent anti-apoptotic and neuronal differentiation-inducing effects in PC12 and mouse neural stem cells. Eur J Pharmacol. 2018;841:104-112 pubmed publisher
    ..FA induced this effect through stabilization and degradation of P53 by increasing the expression rate of SIRT1, SIRT7 and MDM2 but down-regulation of USP7...
  21. Kumari S, Chaurasia S, Nayak M, Mallick R, Dash D. Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia. J Biol Chem. 2015;290:12290-9 pubmed publisher
    ..In humans, seven sirtuin isoforms (Sirt1 to Sirt7) have been identified...
  22. Li W, Zhu D, Qin S. SIRT7 suppresses the epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis by promoting SMAD4 deacetylation. J Exp Clin Cancer Res. 2018;37:148 pubmed publisher
    ..Recently, studies have indicated that sirtuin7 (SIRT7) is implicated in tumor genesis; however, the potential role of SIRT7 in the EMT and metastasis of OSCC has not ..
  23. Fukuda M, Yoshizawa T, Karim M, Sobuz S, Korogi W, Kobayasi D, et al. SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix. Nat Commun. 2018;9:2833 pubmed publisher
    ..Germline Sirt7 knockout mice develop severe osteopenia characterized by decreased bone formation and an increase of osteoclasts...
  24. Lim R, Barker G, Menon R, Lappas M. A Novel Role for SIRT3 in Regulating Mediators Involved in the Terminal Pathways of Human Labor and Delivery. Biol Reprod. 2016;95:95 pubmed
    ..In this study, we determined the effect of term labor and pro-inflammatory cytokines on SIRT3, SIRT4, SIRT5, and SIRT7 expression in human myometrium...
  25. Chen T, Li J, Liu J, Li N, Wang S, Liu H, et al. Activation of SIRT3 by resveratrol ameliorates cardiac fibrosis and improves cardiac function via the TGF-β/Smad3 pathway. Am J Physiol Heart Circ Physiol. 2015;308:H424-34 pubmed publisher
    Sirtuins [sirtuin (SIRT)1-SIRT7] mediate the longevity-promoting effects of calorie restriction in yeast, worms, flies, and mice...
  26. Valdez B, Li Y, Murray D, Ji J, Liu Y, Popat U, et al. Comparison of the cytotoxicity of cladribine and clofarabine when combined with fludarabine and busulfan in AML cells: Enhancement of cytotoxicity with epigenetic modulators. Exp Hematol. 2015;43:448-61.e2 pubmed publisher
    ..activation of the ATM pathway; increase in histone modifications; decrease in HDAC3, HDAC4, HDAC5 and SirT7 proteins; decrease in mitochondrial membrane potential; activation of apoptosis and stress signaling pathways; and ..
  27. Lewinska A, Wnuk M, Grabowska W, Zabek T, Semik E, Sikora E, et al. Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells. Toxicol Lett. 2015;233:227-38 pubmed publisher
    ..Curcumin caused inhibition of rDNA transcription, which could be due to SIRT7 downregulation, site-specific methylation of RNA18S5 gene promoter or both...
  28. Igci M, Kalender M, Borazan E, Bozgeyik I, Bayraktar R, Bozgeyik E, et al. High-throughput screening of Sirtuin family of genes in breast cancer. Gene. 2016;586:123-8 pubmed publisher
    ..In contrast, SIRT2, SIRT3, and SIRT5 genes were shown to be up-regulated in our study. Although SIRT6 and SIRT7 were also up-regulated in breast cancer tissues, these expression changes were statistically insignificant...
  29. Li Z, Bridges B, Olson J, Weinman S. The interaction between acetylation and serine-574 phosphorylation regulates the apoptotic function of FOXO3. Oncogene. 2017;36:1887-1898 pubmed publisher
    ..We observed that both sirtuins 1 and 7 (SIRT1 and SIRT7) are able to deacetylate FOXO3 in vitro and in vivo, and that lipopolysaccharide (LPS) treatment of THP-1 ..
  30. Wong D, Soga T, Parhar I. Aging and chronic administration of serotonin-selective reuptake inhibitor citalopram upregulate Sirt4 gene expression in the preoptic area of male mice. Front Genet. 2015;6:281 pubmed publisher
    ..Age-related increases of sirt1, sirt4, sirt5, and sirt7 mRNA levels were observed in the POA of 52 weeks old mice...
  31. Lu C, Hsu C, Lin P, Lai C, Lin H, Yang C, et al. The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma. Anticancer Res. 2014;34:7137-43 pubmed
    ..In the cancer group, the expression level of SIRT1 was down-regulated (p<0.05); in contrast, SIRT6 and SIRT7 were significantly up-regulated (p<0.001)...
  32. Wu Y, Meng X, Huang C, Li J. Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target. Tumour Biol. 2015;36:4063-74 pubmed publisher
    ..SIRT1 (silent information regulator 1), a member of mammalian sirtuin family protein (SIRT1-SIRT7), functions as a conserved nicotinamide adenine dinucleotide (NAD)+-dependent deacetylase to implicate in the ..
  33. Li L, Shi L, Yang S, Yan R, Zhang D, Yang J, et al. SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability. Nat Commun. 2016;7:12235 pubmed publisher
    Although SIRT7 is a member of sirtuin family proteins that are described as NAD(+)-dependent class III histone deacetylases, the intrinsic enzymatic activity of this sirtuin protein remains to be investigated and the cellular function of ..
  34. Li H, Tian Z, Qu Y, Yang Q, Guan H, Shi B, et al. SIRT7 promotes thyroid tumorigenesis through phosphorylation and activation of Akt and p70S6K1 via DBC1/SIRT1 axis. Oncogene. 2019;38:345-359 pubmed publisher
    b>SIRT7 is an NAD+-dependent histone/non-histone deacetylase, which is highly expressed in different types of cancer including thyroid cancer; however, its biological function in thyroid cancer is still undiscovered...
  35. Paredes S, Angulo Ibáñez M, Tasselli L, Carlson S, Zheng W, Li T, et al. The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability. J Biol Chem. 2018;293:11242-11250 pubmed publisher
    ..Here, we uncovered a pivotal role of sirtuin 7 (SIRT7), a mammalian Sir2 homolog, in guarding against rDNA instability and show that this function of SIRT7 protects ..
  36. Blank M, Chen S, Poetz F, Schnolzer M, Voit R, Grummt I. SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription. Nucleic Acids Res. 2017;45:2675-2686 pubmed publisher
    b>SIRT7 is an NAD+-dependent protein deacetylase that regulates cell growth and proliferation. Previous studies have shown that SIRT7 is required for RNA polymerase I (Pol I) transcription and pre-rRNA processing...
  37. Kiran S, Anwar T, Kiran M, Ramakrishna G. Sirtuin 7 in cell proliferation, stress and disease: Rise of the Seventh Sirtuin!. Cell Signal. 2015;27:673-82 pubmed publisher
    ..Sirtuins were originally discovered in yeast for its role in prolonging replicative lifespan. Until recently SIRT7 happened to be the least studied sirtuin of the seven mammalian sirtuins...
  38. Araki S, Izumiya Y, Rokutanda T, Ianni A, Hanatani S, Kimura Y, et al. Sirt7 Contributes to Myocardial Tissue Repair by Maintaining Transforming Growth Factor-β Signaling Pathway. Circulation. 2015;132:1081-93 pubmed publisher
    b>Sirt7, 1 of the 7 members of the mammalian sirtuin family, promotes oncogenic transformation. Tumor growth and metastasis require fibrotic and angiogenic responses...
  39. Song C, Hotz Wagenblatt A, Voit R, Grummt I. SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability. Genes Dev. 2017;31:1370-1381 pubmed publisher
    ..Acetylation by CBP inhibits DDX21 activity, while deacetylation by SIRT7 augments helicase activity and overcomes R-loop-mediated stalling of RNA polymerases...
  40. Miyasato Y, Yoshizawa T, Sato Y, Nakagawa T, Miyasato Y, Kakizoe Y, et al. Sirtuin 7 Deficiency Ameliorates Cisplatin-induced Acute Kidney Injury Through Regulation of the Inflammatory Response. Sci Rep. 2018;8:5927 pubmed publisher
    ..Sirtuin 1 (SIRT1) and SIRT3 play protective roles against cisplatin-induced kidney injury. However, the role of SIRT7 in cisplatin-induced kidney injury is not yet known...
  41. Aljada A, Saleh A, Alkathiri M, Shamsa H, Al Bawab A, Nasr A. Altered Sirtuin 7 Expression is Associated with Early Stage Breast Cancer. Breast Cancer (Auckl). 2015;9:3-8 pubmed publisher
    To evaluate sirtuin-7 (SirT7) mRNA expression status in breast cancer patients with different metastatic stages and survey SirT7 mRNA expression status in eight different types of cancer...
  42. Rouble A, Storey K. Characterization of the SIRT family of NAD+-dependent protein deacetylases in the context of a mammalian model of hibernation, the thirteen-lined ground squirrel. Cryobiology. 2015;71:334-43 pubmed publisher
    ..assess this possibility, protein levels of the seven mammalian SIRTs (SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6 and SIRT7), total SIRT activity, and the acetylation status of two downstream SIRT targets (SOD2K68 and NF-κB p65K310) ..
  43. Deng J, Kong K, Gao W, Tang H, Chaudhary V, Cheng Y, et al. Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription. Biochim Biophys Acta Gene Regul Mech. 2017;1860:491-501 pubmed publisher
    ..All human sirtuins SIRT1 through SIRT7 activated HBV gene expression...
  44. Malik S, Villanova L, Tanaka S, Aonuma M, Roy N, Berber E, et al. SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors. Sci Rep. 2015;5:9841 pubmed publisher
    ..Here, we identify the chromatin regulatory Sirtuin factor SIRT7 as a key regulator of metastatic phenotypes in both epithelial and mesenchymal cancer cells...
  45. Temel M, Koç M, Ulutaş S, Göğebakan B. The expression levels of the sirtuins in patients with BCC. Tumour Biol. 2016;37:6429-35 pubmed publisher
    ..1, Sirt1.2, Sirt2, Sirt3, Sirt4, Sirt5, Sirt6, and Sirt7) were examined by real-time PCR. The results showed that expressions of SIRT1.1, SIRT1...
  46. Kida Y, Goligorsky M. Sirtuins, Cell Senescence, and Vascular Aging. Can J Cardiol. 2016;32:634-41 pubmed publisher
    ..family members have been identified in mammals, from SIRT1, the best studied for its role in vascular aging, to SIRT7. SIRT1 and SIRT2 are localized in the nucleus and cytoplasm...
  47. Priyanka A, Solanki V, Parkesh R, Thakur K. Crystal structure of the N-terminal domain of human SIRT7 reveals a three-helical domain architecture. Proteins. 2016;84:1558-63 pubmed publisher
    Human SIRT7 is an NAD(+) dependent deacetylase, which belongs to sirtuin family of proteins. SIRT7, like other sirtuins has conserved catalytic domain and is flanked by N- and C-terminal domains reported to play vital functional roles...
  48. Fang P, Xue Y, Zhang Y, Fan N, Ou L, Leng L, et al. SIRT7 regulates the TGF-?1-induced proliferation and migration of mouse airway smooth muscle cells by modulating the expression of TGF-? receptor I. Biomed Pharmacother. 2018;104:781-787 pubmed publisher
    Accumulating evidence shows that sirtuin 7 (SIRT7), a key mediator of many cellular activities, plays an important role in the pathogenesis of various diseases; however, little is known about the role of SIRT7 in asthma, which is ..
  49. Nahalkova J. The protein-interaction network with functional roles in tumorigenesis, neurodegeneration, and aging. Mol Cell Biochem. 2016;423:187-196 pubmed
    ..All the detected interacting proteins TPPII, p53, MYBBP1A, CDK2 and SIRT7, SIRT6, and CD147 are suitable for the development of antitumor therapeutics and treatments for diseases of aging...
  50. Wang X, Song Y. MicroRNA-340 inhibits the growth and invasion of angiosarcoma cells by targeting SIRT7. Biomed Pharmacother. 2018;103:1061-1068 pubmed publisher
    ..Bioinformatics analysis predicted that Sirtuin 7 (SIRT7) was a potential target gene of miR-340...
  51. Winnik S, Auwerx J, Sinclair D, Matter C. Protective effects of sirtuins in cardiovascular diseases: from bench to bedside. Eur Heart J. 2015;36:3404-12 pubmed publisher
    Sirtuins (Sirt1-Sirt7) comprise a family of nicotinamide adenine dinucleotide (NAD(+))-dependent enzymes...
  52. Wronska A, Lawniczak A, Wierzbicki P, Kmiec Z. Age-Related Changes in Sirtuin 7 Expression in Calorie-Restricted and Refed Rats. Gerontology. 2016;62:304-10 pubmed publisher
    ..While the physiological functions of SIRT7 are still poorly understood, SIRT7 has recently been shown to affect ribosome biogenesis, mitochondrial gene ..
  53. Sun L, Fan G, Shan P, Qiu X, Dong S, Liao L, et al. Regulation of energy homeostasis by the ubiquitin-independent REG? proteasome. Nat Commun. 2016;7:12497 pubmed publisher
    ..limits cellular rDNA transcription and energy consumption by targeting the rDNA transcription activator SirT7 for ubiquitin-independent degradation under normal conditions...
  54. Wang H, Liu S, Liu S, Wei W, Zhou X, Lin F, et al. Enhanced expression and phosphorylation of Sirt7 activates smad2 and ERK signaling and promotes the cardiac fibrosis differentiation upon angiotensin-II stimulation. PLoS ONE. 2017;12:e0178530 pubmed publisher
    ..However, regulation of this phenotypic transformation remains unclear. Here, we showed that sirtuin-7 (Sirt7) plays an important role in the regulation of MFs differentiation...
  55. Poulose N, Raju R. Sirtuin regulation in aging and injury. Biochim Biophys Acta. 2015;1852:2442-55 pubmed publisher
    ..Humans encode seven sirtuin isoforms SIRT1-SIRT7 with varying intracellular distribution...
  56. Zhang P, Li G, Deng Z, Liu L, Chen L, Tang J, et al. Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents. Nucleic Acids Res. 2016;44:3629-42 pubmed publisher
    ..Here we showed that the human Dicer protein interacts with SIRT7, an NAD(+)-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase, and holds a proportion of SIRT7 in ..
  57. Ren J, Xu N, Ma Z, Li Y, Li C, Wang Y, et al. Characteristics of expression and regulation of sirtuins in chicken (Gallus gallus). Genome. 2017;60:431-440 pubmed publisher
    Sirtuins (SIRT1-SIRT7) are a family of NAD+-dependent protein deacetylases that are linked to post-translational regulation of many metabolic processes...
  58. Li W, Sun Z, Chen C, Wang L, Geng Z, Tao J. Sirtuin7 has an oncogenic potential via promoting the growth of cholangiocarcinoma cells. Biomed Pharmacother. 2018;100:257-266 pubmed publisher
    Accumulating evidence indicates that sirtuin7 (SIRT7) plays an oncogenic role in the main types of liver cancer, hepatocellular carcinoma (HCC)...
  59. Nahálková J. Novel protein-protein interactions of TPPII, p53, and SIRT7. Mol Cell Biochem. 2015;409:13-22 pubmed publisher
    Novel protein-protein interactions of TPPII, SIRT7, and p53 were detected by co-immunoprecipitation using both HeLa cell lysates and the cytoplasmic fraction prepared by fractionation of mouse liver tissue...
  60. Kurylowicz A, Owczarz M, Polosak J, Jonas M, Lisik W, Jonas M, et al. SIRT1 and SIRT7 expression in adipose tissues of obese and normal-weight individuals is regulated by microRNAs but not by methylation status. Int J Obes (Lond). 2016;40:1635-1642 pubmed publisher
    ..The expression of SIRTs and of SIRT1 and SIRT7 mRNA-interacting miRNAs was evaluated by real-time PCR in visceral adipose tissue (VAT) and subcutaneous adipose ..
  61. Yamagata K, Yoshizawa T. Transcriptional Regulation of Metabolism by SIRT1 and SIRT7. Int Rev Cell Mol Biol. 2018;335:143-166 pubmed publisher
    ..Recent findings have identified critical roles for SIRT1 and SIRT7 in glucose/lipid metabolism in multiple tissues...
  62. Cioffi M, Vallespinos Serrano M, Trabulo S, Fernandez Marcos P, Firment A, Vazquez B, et al. MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3. Cell Rep. 2015;12:1594-605 pubmed publisher
    ..Second, miR-93 inhibits the metabolic target Sirt7, which we identified as a major driver of in vivo adipogenesis via induction of differentiation and maturation of ..
  63. Jesko H, Wencel P, Strosznajder R, Strosznajder J. Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders. Neurochem Res. 2017;42:876-890 pubmed publisher
    Sirtuins (SIRT1-SIRT7) are unique histone deacetylases (HDACs) whose activity depends on NAD+ levels and thus on the cellular metabolic status. SIRTs regulate energy metabolism and mitochondrial function...
  64. Potenza N, Mosca N, Zappavigna S, Castiello F, Panella M, Ferri C, et al. MicroRNA-125a-5p Is a Downstream Effector of Sorafenib in Its Antiproliferative Activity Toward Human Hepatocellular Carcinoma Cells. J Cell Physiol. 2017;232:1907-1913 pubmed publisher
    ..J. Cell. Physiol. 232: 1907-1913, 2017. © 2016 Wiley Periodicals, Inc. ..
  65. Lv J, Tian J, Zheng G, Zhao J. Sirtuin7 is involved in protecting neurons against oxygen-glucose deprivation and reoxygenation-induced injury through regulation of the p53 signaling pathway. J Biochem Mol Toxicol. 2017;31: pubmed publisher
    Sirtuin7 (SIRT7) is known to regulate apoptosis and stress responses. So far, very little is known about the role of SIRT7 in cerebral ischemia/reperfusion injury...
  66. Freitas M, Rodrigues A, Tomada N, Fonseca J, Magalhães A, Gouveia A, et al. Effects of Aging and Cardiovascular Disease Risk Factors on the Expression of Sirtuins in the Human Corpus Cavernosum. J Sex Med. 2015;12:2141-52 pubmed publisher
    ..and SIRT5-7 mRNAs were detected in all individuals, without statistical differences among groups, excepting SIRT7 that decreased four times in aged groups relatively to young (P = 0.013)...
  67. Korogi W, Yoshizawa T, Karim M, Tanoue H, Yugami M, Sobuz S, et al. SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development. Biochem Biophys Res Commun. 2018;: pubmed publisher
    ..homeostasis and cartilage diseases have been well studied, there is no information on the contribution of SIRT7 to cartilage homeostasis and osteoarthritis (OA) pathologies...
  68. Panella M, Mosca N, Di Palo A, Potenza N, Russo A. Mutual suppression of miR-125a and Lin28b in human hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2018;500:824-827 pubmed publisher
    ..Overall, these data support a tumor suppressive role for miR-125a and contribute to the elucidation of its molecular targets. ..
  69. Vazquez B, Thackray J, Simonet N, Kane Goldsmith N, Martínez Redondo P, Nguyen T, et al. SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair. EMBO J. 2016;35:1488-503 pubmed publisher
    ..The enzymatic activity of the mammalian sirtuin SIRT7 targets acetylated lysine in the N-terminal tail of histone H3 (H3K18Ac), thus modulating chromatin structure and ..
  70. Zhou X, Xie Y, Xiao H, Deng X, Wang Y, Jiang L, et al. MicroRNA-519d inhibits proliferation and induces apoptosis of human hypertrophic scar fibroblasts through targeting Sirtuin 7. Biomed Pharmacother. 2018;100:184-190 pubmed publisher
    ..In contrast, suppression of miR-519d showed the opposite effects. Interestingly, Sirtuin 7 (SIRT7) was identified as a target gene of miR-519d...
  71. Shin J, Chen D. Molecular, Cellular, and Physiological Characterization of Sirtuin 7 (SIRT7). Methods Mol Biol. 2016;1436:271-7 pubmed publisher
    Sirtuin 7 (SIRT7), a histone 3 lysine 18 (H3K18) deacetylase, functions at chromatin to suppress endoplasmic reticulum (ER) stress and mitochondrial protein folding stress (PFS(mt)), and prevent the development of fatty liver disease and ..
  72. Coppola N, de Stefano G, Panella M, Onorato L, Iodice V, Minichini C, et al. Lowered expression of microRNA-125a-5p in human hepatocellular carcinoma and up-regulation of its oncogenic targets sirtuin-7, matrix metalloproteinase-11, and c-Raf. Oncotarget. 2017;8:25289-25299 pubmed publisher
  73. Büssow K, Cahill D, Nietfeld W, Bancroft D, Scherzinger E, Lehrach H, et al. A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. Nucleic Acids Res. 1998;26:5007-8 pubmed
    ..His antibody, Qiagen) detected 20% of the library as putative expression clones. Two example genes, GAPDH and HSP90alpha, were identified on high-density filters using DNA probes and antibodies against their proteins. ..
  74. Shin J, He M, Liu Y, Paredes S, Villanova L, Brown K, et al. SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Rep. 2013;5:654-665 pubmed publisher
    ..Its pathogenesis is poorly understood, and therapeutic options are limited. Here, we show that SIRT7, an NAD(+)-dependent H3K18Ac deacetylase, functions at chromatin to suppress ER stress and prevent the development ..
  75. Liu X, Yang L, Tu J, Cai W, Zhang M, Shou Z, et al. microRNA-526b servers as a prognostic factor and exhibits tumor suppressive property by targeting Sirtuin 7 in hepatocellular carcinoma. Oncotarget. 2017;8:87737-87749 pubmed publisher
    ..Mechanistically, we proved that miR-526b could directly bind to 3'UTR of sirtuin 7 (SIRT7) mRNA and repressed its expression. miR-526b and SIRT7 showed a negative correlation in HCC tissues...
  76. de Nigris F, Cerutti J, Morelli C, Califano D, Chiariotti L, Viglietto G, et al. Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues. Br J Cancer. 2002;87:1479 pubmed
  77. Nihira N, Ogura K, Shimizu K, North B, Zhang J, Gao D, et al. Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function. Sci Signal. 2017;10: pubmed publisher
    ..Therefore, this study indicates that dynamic acetylation is a molecular switch in the regulation of MDM2 substrate specificity, revealing further insight into the posttranslational regulation of the MDM2/p53 cell survival axis. ..
  78. Wang H, Lu R, Xie S, Zheng H, Wen X, Gao X, et al. SIRT7 Exhibits Oncogenic Potential in Human Ovarian Cancer Cells. Asian Pac J Cancer Prev. 2015;16:3573-7 pubmed
    Sirtuin7 (SIRT7) is a type of nicotinamide adenine dinucleotide oxidized form (NAD+)-dependent deacetylase and the least understood member of the sirtuins family; it is implicated in various processes, such as aging, DNA damage repair ..
  79. Jiang L, Xiong J, Zhan J, Yuan F, Tang M, Zhang C, et al. Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis. J Biol Chem. 2017;292:13296-13311 pubmed publisher
    Sirtuin 7 (SIRT7), a member of the NAD+-dependent class III histone deacetylases, is involved in the regulation of various cellular processes and in resisting various stresses, such as hypoxia, low glucose levels, and DNA ..
  80. Kiran S, Chatterjee N, Singh S, Kaul S, Wadhwa R, Ramakrishna G. Intracellular distribution of human SIRT7 and mapping of the nuclear/nucleolar localization signal. FEBS J. 2013;280:3451-66 pubmed publisher
    Sirtuins belong to a class of NAD-dependent deacetylases, and include seven distinct isoforms, of which SIRT7 is the least studied member...
  81. McGlynn L, McCluney S, Jamieson N, Thomson J, MacDonald A, Oien K, et al. SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients. PLoS ONE. 2015;10:e0131344 pubmed publisher
    ..Low levels of nuclear SIRT7 expression were also associated with an aggressive tumour phenotype and poorer outcome, as measured by disease-..
  82. Barber M, Michishita Kioi E, Xi Y, Tasselli L, Kioi M, Moqtaderi Z, et al. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature. 2012;487:114-8 pubmed publisher
    Sirtuin proteins regulate diverse cellular pathways that influence genomic stability, metabolism and ageing. SIRT7 is a mammalian sirtuin whose biochemical activity, molecular targets and physiological functions have been unclear...
  83. Lee N, Kim D, Kim E, Park S, Kwon J, Shin J, et al. Comparative interactomes of SIRT6 and SIRT7: Implication of functional links to aging. Proteomics. 2014;14:1610-22 pubmed publisher
    ..Although diverse functions of sirtuins have been proposed, those functions of SIRT6 and SIRT7 that are mediated by their interacting proteins remain elusive...
  84. Islam M, Wei F, Ohta K, Shigematsu N, Fukuda T, Tomizawa K, et al. Sirtuin 7 is involved in the consolidation of fear memory in mice. Biochem Biophys Res Commun. 2018;495:261-266 pubmed publisher
    Sirtuin 7 (SIRT7) is an NAD+-dependent deacetylase/deacylase, and is involved in a variety of biological processes relevant to the transcription of rRNA, the DNA damage response, tumorigenesis, and metabolism...
  85. Tsai Y, Greco T, Cristea I. Sirtuin 7 plays a role in ribosome biogenesis and protein synthesis. Mol Cell Proteomics. 2014;13:73-83 pubmed publisher
    It has been shown that SIRT7 regulates rDNA transcription and that reduced SIRT7 levels inhibit tumor growth. This anti-tumor effect could be due to reduced Pol I activity and perturbed ribosome biogenesis...
  86. Tsai Y, Greco T, Boonmee A, Miteva Y, Cristea I. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. Mol Cell Proteomics. 2012;11:M111.015156 pubmed publisher
    Among mammalian sirtuins, SIRT7 is the only enzyme residing in nucleoli where ribosomal DNA is transcribed. Recent reports established that SIRT7 associates with RNA Pol I machinery and is required for rDNA transcription...
  87. Potenza N, Panella M, Castiello F, Mosca N, Amendola E, Russo A. Molecular mechanisms governing microRNA-125a expression in human hepatocellular carcinoma cells. Sci Rep. 2017;7:10712 pubmed publisher
    ..This finding contributes to explain the increased levels of miR-125a observed in the liver of patients with chronic hepatitis B. ..
  88. Wei W, Jing Z, Ke Z, Yi P. Sirtuin 7 plays an oncogenic role in human osteosarcoma via downregulating CDC4 expression. Am J Cancer Res. 2017;7:1788-1803 pubmed
    It is still a controversy whether the role of Sirtuin 7 (SIRT7) is an oncogene or a tumor suppressor gene in cancer as SIRT7 may have different functions in different types of cancer...
  89. Ianni A, Hoelper S, Krueger M, Braun T, Bober E. Sirt7 stabilizes rDNA heterochromatin through recruitment of DNMT1 and Sirt1. Biochem Biophys Res Commun. 2017;492:434-440 pubmed publisher
    ..Here, we investigated the role of Sirtuin 7 (Sirt7) in the regulation of rDNA chromatin structure, rDNA repeat stability and nucleolar organization...
  90. Aljada A, Saleh A, Al Suwaidan S. Modulation of insulin/IGFs pathways by sirtuin-7 inhibition in drug-induced chemoreistance. Diagn Pathol. 2014;9:94 pubmed publisher
    ..breast cancer (MCF-7), osteosarcoma (SaOS-2), and ovarian cancer (A2780) and to examine the effect of Sirtuin-7 (Sirt7) inhibition on insulin/IGFs pathways in MCF-7 cell line...
  91. Gu S, Ran S, Liu B, Liang J. miR-152 induces human dental pulp stem cell senescence by inhibiting SIRT7 expression. FEBS Lett. 2016;590:1123-31 pubmed publisher
    ..Sirtuin 7 (SIRT7) was identified as a target of miR-152...
  92. Chen X, Li W, Wu X, Zhang H, Chen L, Zhang P, et al. Dicer regulates non-homologous end joining and is associated with chemosensitivity in colon cancer patients. Carcinogenesis. 2017;38:873-882 pubmed publisher
    ..Dicer knockdown increased SIRT7 binding and decreased the level of H3K18Ac (acetylated lysine 18 of histone H3) at DSB sites, thereby repressing ..