SIRT3

Summary

Gene Symbol: SIRT3
Description: sirtuin 3
Alias: SIR2L3, NAD-dependent protein deacetylase sirtuin-3, mitochondrial, NAD-dependent deacetylase sirtuin-3, mitochondrial, SIR2-like protein 3, mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase, regulatory protein SIR2 homolog 3, silent mating type information regulation 2, S.cerevisiae, homolog 3, sir2-like 3, sirtuin type 3
Species: human
Products:     SIRT3

Top Publications

  1. Finley L, Carracedo A, Lee J, Souza A, Egia A, Zhang J, et al. SIRT3 opposes reprogramming of cancer cell metabolism through HIF1? destabilization. Cancer Cell. 2011;19:416-28 pubmed publisher
    ..Here, we show that the mitochondrial NAD-dependent deacetylase SIRT3 is a crucial regulator of the Warburg effect...
  2. Schlicker C, Gertz M, Papatheodorou P, Kachholz B, Becker C, Steegborn C. Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. J Mol Biol. 2008;382:790-801 pubmed publisher
    ..Mammalian mitochondria contain three Sirtuins, Sirt3, Sirt4, and Sirt5...
  3. Iwahara T, Bonasio R, Narendra V, Reinberg D. SIRT3 functions in the nucleus in the control of stress-related gene expression. Mol Cell Biol. 2012;32:5022-34 pubmed publisher
    b>SIRT3 is a member of the Sir2 family of NAD(+)-dependent protein deacetylases that promotes longevity in many organisms...
  4. Schwer B, North B, Frye R, Ott M, Verdin E. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol. 2002;158:647-57 pubmed
    ..These observations demonstrate the existence of a latent class III deacetylase that becomes catalytically activated upon import into the human mitochondria...
  5. Michishita E, Park J, Burneskis J, Barrett J, Horikawa I. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell. 2005;16:4623-35 pubmed
    ..and SIRT7 are associated with heterochromatic regions and nucleoli, respectively, where yeast Sir2 functions; 2) SIRT3, SIRT4, and SIRT5 are localized in mitochondria, an organelle that links aging and energy metabolism; 3) cellular ..
  6. Weir H, Murray T, Kehoe P, Love S, VERDIN E, O Neill M, et al. CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease. PLoS ONE. 2012;7:e48225 pubmed publisher
    ..An essential regulator of mitochondrial function is the deacetylase, sirtuin 3 (SIRT3)...
  7. Tseng A, Shieh S, Wang D. SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage. Free Radic Biol Med. 2013;63:222-34 pubmed publisher
    Progressive accumulation of defective mitochondria is a common feature of aged cells. SIRT3 is a NAD(+)-dependent protein deacetylase that regulates mitochondrial function and metabolism in response to caloric restriction and stress...
  8. Bellizzi D, Rose G, Cavalcante P, Covello G, Dato S, De Rango F, et al. A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics. 2005;85:258-63 pubmed
    ..First, we searched for variability in the human sirtuin 3 gene (SIRT3) and discovered a VNTR polymorphism (72-bp repeat core) in intron 5...
  9. Bell E, Emerling B, Ricoult S, Guarente L. SirT3 suppresses hypoxia inducible factor 1? and tumor growth by inhibiting mitochondrial ROS production. Oncogene. 2011;30:2986-96 pubmed publisher
    ..Here, we show that the mitochondrial sirtuin, SirT3, acts as a tumor suppressor via its ability to suppress reactive oxygen species (ROS) and regulate hypoxia ..

More Information

Publications61

  1. Chen Y, Zhang J, Lin Y, Lei Q, Guan K, Zhao S, et al. Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. EMBO Rep. 2011;12:534-41 pubmed publisher
    ..Mitochondrial deacetylase SIRT3 binds to, deacetylates and activates SOD2...
  2. Frye R. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem Biophys Res Commun. 1999;260:273-9 pubmed
    ..These results suggest that the sirtuins may function via mono-ADP-ribosylation of proteins. ..
  3. Yang B, Fu X, Shao L, Ding Y, Zeng D. Aberrant expression of SIRT3 is conversely correlated with the progression and prognosis of human gastric cancer. Biochem Biophys Res Commun. 2014;443:156-60 pubmed publisher
    b>SIRT3 is a NAD(+)-dependent histone deacetylaseand and plays a critical role in various human carcinomas. However, its precise role in the pathogenesis of gastric cancer (GC) is still unclear...
  4. Bellizzi D, Dato S, Cavalcante P, Covello G, Di Cianni F, Passarino G, et al. Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13. Genomics. 2007;89:143-50 pubmed
    The human SIRT3 gene contains an intronic VNTR enhancer whose variability is correlated with life span. The SIRT3 5' flanking region encompasses the PSMD13 gene encoding the p40.5 regulator subunit of the 26S proteasome...
  5. Schwer B, Bunkenborg J, Verdin R, Andersen J, Verdin E. Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A. 2006;103:10224-10229 pubmed publisher
    ..AceCS2 is reversibly acetylated at Lys-642 in the active site of the enzyme. The mitochondrial sirtuin SIRT3 interacts with AceCS2 and deacetylates Lys-642 both in vitro and in vivo...
  6. Zhang L, Ren X, Cheng Y, Huber Keener K, Liu X, Zhang Y, et al. Identification of Sirtuin 3, a mitochondrial protein deacetylase, as a new contributor to tamoxifen resistance in breast cancer cells. Biochem Pharmacol. 2013;86:726-33 pubmed publisher
    The current study reports a previously unappreciated role of Sirtuin 3 (SIRT3), a mitochondrial protein deacetylase, in altering sensitivity of breast cancer cells to tamoxifen (Tam), a commonly used anti-estrogen agent...
  7. Allison S, Milner J. SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways. Cell Cycle. 2007;6:2669-77 pubmed
    b>SIRT3, one of seven mammalian sirtuins, is a NAD-dependent deacetylase. SIRT3 localizes to mitochondria where it deacetylates and thus activates acetyl-CoA synthetase 2 (AceCS2), indicating a role for SIRT3 in metabolism...
  8. Haigis M, Deng C, Finley L, Kim H, Gius D. SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis. Cancer Res. 2012;72:2468-72 pubmed publisher
    ..However, the mechanisms by which these processes are linked remain largely elusive. Murine tumors lacking Sirt3 exhibit abnormally high levels of ROS that directly induce genomic instability and increase hypoxia-inducible ..
  9. Yu W, Dittenhafer Reed K, Denu J. SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status. J Biol Chem. 2012;287:14078-86 pubmed publisher
    ..Previously, we demonstrated that the NAD(+)-dependent deacetylase SIRT3 was essential for the prevention of age-related hearing loss in mice fed a calorically restricted diet...
  10. Park S, Ozden O, Jiang H, Cha Y, Pennington J, Aykin Burns N, et al. Sirt3, mitochondrial ROS, ageing, and carcinogenesis. Int J Mol Sci. 2011;12:6226-39 pubmed publisher
    ..Based on these results it has been hypothesized that Sirt3 functions as a mitochondrial fidelity protein whose function governs both aging and carcinogenesis by modulating ..
  11. Chen Y, Fu L, Wen X, Wang X, Liu J, Cheng Y, et al. Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer. Cell Death Dis. 2014;5:e1047 pubmed publisher
    Sirtuin-3 (SIRT3), a major mitochondria NAD+-dependent deacetylase, may target mitochondrial proteins for lysine deacetylation and also regulate cellular functions...
  12. Kim H, Patel K, Muldoon Jacobs K, Bisht K, Aykin Burns N, Pennington J, et al. SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell. 2010;17:41-52 pubmed publisher
    ..This work demonstrates that SIRT3(-/-) mouse embryonic fibroblasts (MEFs) exhibit abnormal mitochondrial physiology as well as increases in stress-..
  13. Li S, Banck M, Mujtaba S, Zhou M, SUGRUE M, Walsh M. p53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylase. PLoS ONE. 2010;5:e10486 pubmed publisher
    ..In order to address the role of p53 in navigating cellular senescence through the mitochondria, we identified SirT3 to rescue EJ/p53 cells from induced p53-mediated growth arrest...
  14. Lescai F, Blanche H, Nebel A, Beekman M, Sahbatou M, Flachsbart F, et al. Human longevity and 11p15.5: a study in 1321 centenarians. Eur J Hum Genet. 2009;17:1515-9 pubmed publisher
    The 11p15.5 chromosomal region (2.8 Mb) is of particular interest as it encloses five genes (HRAS1, SIRT3, TH, INS and IGF2), the variability of which was found to be associated with life extension by association studies...
  15. Jin L, Wei W, Jiang Y, Peng H, Cai J, Mao C, et al. Crystal structures of human SIRT3 displaying substrate-induced conformational changes. J Biol Chem. 2009;284:24394-405 pubmed publisher
    b>SIRT3 is a major mitochondrial NAD(+)-dependent protein deacetylase playing important roles in regulating mitochondrial metabolism and energy production and has been linked to the beneficial effects of exercise and caloric restriction...
  16. Yang Y, Chen Y, Zhang C, Nimmakayalu M, Ward D, Weissman S. Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene. Genomics. 2000;69:355-69 pubmed
    ..the two mouse Sir2-like proteins (mSIR2L2 and mSIR2L3) are most similar to the human Sir2-like proteins SIR2L2 and SIR2L3, respectively...
  17. Cooper H, Spelbrink J. The human SIRT3 protein deacetylase is exclusively mitochondrial. Biochem J. 2008;411:279-85 pubmed publisher
    ..suggested that perhaps as many as 20% of all mitochondrial proteins are regulated through lysine acetylation while SIRT3 has been implicated as an important mitochondrial protein deacetylase...
  18. Xiao K, Jiang J, Wang W, Cao S, Zhu L, Zeng H, et al. Sirt3 is a tumor suppressor in lung adenocarcinoma cells. Oncol Rep. 2013;30:1323-8 pubmed publisher
    b>Sirt3, a member of the mammalian sirtuin family protein that is localized to mitochondria, is a NAD+-dependent deacetylase and plays an important role in the control of metabolic activity...
  19. Onyango P, Celic I, McCaffery J, Boeke J, Feinberg A. SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc Natl Acad Sci U S A. 2002;99:13653-8 pubmed
    ..We previously identified a large imprinted gene domain on 11p15.5 and investigated the 11p15.5 sirtuin SIRT3. Although this gene was not imprinted, we found that it is localized to mitochondria, with a mitochondrial ..
  20. Li H, Feng Z, Wu W, Li J, Zhang J, Xia T. SIRT3 regulates cell proliferation and apoptosis related to energy metabolism in non-small cell lung cancer cells through deacetylation of NMNAT2. Int J Oncol. 2013;43:1420-30 pubmed publisher
    ..As a major mitochondrial deacetylase, SIRT3 regulates the activity of enzymes to coordinate global shifts in cellular metabolism and has important ..
  21. Frye R. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun. 2000;273:793-8 pubmed
    ..The seven human sirtuin genes include all four classes: SIRT1, SIRT2, and SIRT3 are class I, SIRT4 is class II, SIRT5 is class III, and SIRT6 and SIRT7 are class IV.
  22. Scott I, Webster B, Li J, Sack M. Identification of a molecular component of the mitochondrial acetyltransferase programme: a novel role for GCN5L1. Biochem J. 2012;443:655-61 pubmed publisher
    b>SIRT3 (sirtuin 3) modulates respiration via the deacetylation of lysine residues in electron transport chain proteins. Whether mitochondrial protein acetylation is controlled by a counter-regulatory program has remained elusive...
  23. Scher M, Vaquero A, Reinberg D. SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes Dev. 2007;21:920-8 pubmed
    ..b>SirT3 levels have been shown to correlate with extended life span, to localize to the mitochondria, and to be highly ..
  24. Kong X, Wang R, Xue Y, Liu X, Zhang H, Chen Y, et al. Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis. PLoS ONE. 2010;5:e11707 pubmed publisher
    Sirtuin 3 (SIRT3) is one of the seven mammalian sirtuins, which are homologs of the yeast Sir2 gene. SIRT3 is the only sirtuin with a reported association with the human life span...
  25. Jacobs K, Pennington J, Bisht K, Aykin Burns N, Kim H, Mishra M, et al. SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci. 2008;4:291-9 pubmed
    ..Thus, we hypothesize that a mitochondrial Sirtuin (SIRT3) might also interact with and regulate the activity of the FOXO proteins...
  26. Ahuja N, Schwer B, Carobbio S, Waltregny D, North B, Castronovo V, et al. Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J Biol Chem. 2007;282:33583-92 pubmed
    ..Depletion of SIRT4 from insulin-producing INS-1E cells results in increased insulin secretion in response to glucose. These observations define a new role for mitochondrial SIRT4 in the regulation of insulin secretion. ..
  27. Pellegrini L, Pucci B, Villanova L, Marino M, Marfe G, Sansone L, et al. SIRT3 protects from hypoxia and staurosporine-mediated cell death by maintaining mitochondrial membrane potential and intracellular pH. Cell Death Differ. 2012;19:1815-25 pubmed publisher
    Mitochondrial sirtuin 3 (SIRT3) mediates cellular resistance toward various forms of stress...
  28. Kamarajan P, Alhazzazi T, Danciu T, D Silva N, Verdin E, Kapila Y. Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis. Cancer. 2012;118:5800-10 pubmed publisher
    ..Because it is known that sirtuin-3 (SIRT3), a nicotinamide adenine dinucleotide-dependent deacetylase, regulates cell survival, metabolism, and ..
  29. Zhang Y, Zhou L. Sirt3 inhibits hepatocellular carcinoma cell growth through reducing Mdm2-mediated p53 degradation. Biochem Biophys Res Commun. 2012;423:26-31 pubmed publisher
    b>Sirt3 is a member of the mammalian sirtuin family that is localized to mitochondria and plays a role in the control of the metabolic activity...
  30. Sundaresan N, Samant S, Pillai V, Rajamohan S, Gupta M. SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70. Mol Cell Biol. 2008;28:6384-401 pubmed publisher
    ..Among them, SIRT3 is the only sirtuin whose increased expression has been shown to correlate with an extended life span in humans...
  31. Cheng Y, Ren X, Gowda A, Shan Y, Zhang L, Yuan Y, et al. Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress. Cell Death Dis. 2013;4:e731 pubmed publisher
    Sirtuin 3 (Sirt3), a major mitochondrial NAD(+)-dependent deacetylase, targets various mitochondrial proteins for lysine deacetylation and regulates important cellular functions such as energy metabolism, aging, and stress response...
  32. Albani D, Ateri E, Mazzuco S, Ghilardi A, Rodilossi S, Biella G, et al. Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study "Treviso Longeva (TRELONG)". Age (Dordr). 2014;36:469-78 pubmed publisher
    ..Some evidence links SIRT3 to longevity in mammals...
  33. Moschen A, Wieser V, Gerner R, Bichler A, Enrich B, Moser P, et al. Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity. J Hepatol. 2013;59:1315-22 pubmed publisher
    ..effect of weight loss on subcutaneous adipose tissue and liver mRNA and immunohistochemical expression of SIRT1, SIRT3, and SIRT6...
  34. Wei T, Huang G, Gao J, Huang C, Sun M, Wu J, et al. Sirtuin 3 Deficiency Accelerates Hypertensive Cardiac Remodeling by Impairing Angiogenesis. J Am Heart Assoc. 2017;6: pubmed publisher
    ..The nicotinamide adenine dinucleotide-dependent deacetylase Sirtuin 3 (SIRT3) has the potential to modulate angiogenesis, but this has not been confirmed...
  35. Choi J, Koh E, Lee Y, Lee H, Kang H, Yoon Y, et al. Mitochondrial Sirt3 supports cell proliferation by regulating glutamine-dependent oxidation in renal cell carcinoma. Biochem Biophys Res Commun. 2016;474:547-553 pubmed publisher
    ..b>Sirt3 is a major mitochondrial deacetylase that mediates various types of energy metabolism...
  36. Nguyen L, Chen H, Pollock C, Saad S. Sirtuins-mediators of maternal obesity-induced complications in offspring?. FASEB J. 2016;30:1383-90 pubmed publisher
    ..Sirtuins (SIRTs), particularly SIRT1 and SIRT3, are NAD(+)-dependent deacetylases that regulate metabolic balance and stress responses in both central and ..
  37. Kenny T, Germain D. From discovery of the CHOP axis and targeting ClpP to the identification of additional axes of the UPRmt driven by the estrogen receptor and SIRT3. J Bioenerg Biomembr. 2017;49:297-305 pubmed publisher
  38. Xiong Y, Wang M, Zhao J, Wang L, Li X, Zhang Z, et al. SIRT3 is correlated with the malignancy of non-small cell lung cancer. Int J Oncol. 2017;50:903-910 pubmed publisher
    The mitochondrial deacetylase SIRT3 plays a pivotal role in the initiation and the progression of certain cancers acting as an oncogene. However, in others it acts anti-oncogenically...
  39. McGlynn L, McCluney S, Jamieson N, Thomson J, MacDonald A, Oien K, et al. SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients. PLoS ONE. 2015;10:e0131344 pubmed publisher
    ..Low level SIRT3 expression in the tumour cytoplasm correlated with more aggressive tumours, and a shorter time to relapse and ..
  40. Lin J, Kubota S, Ban N, Yoshida M, Santeford A, Sene A, et al. NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice. Cell Rep. 2016;17:69-85 pubmed publisher
    ..We further demonstrate that the NAD(+)-dependent mitochondrial deacylases SIRT3 and SIRT5 play important roles in retinal homeostasis and that NAD(+) deficiency causes SIRT3 dysfunction...
  41. Nihira N, Ogura K, Shimizu K, North B, Zhang J, Gao D, et al. Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function. Sci Signal. 2017;10: pubmed publisher
    ..Therefore, this study indicates that dynamic acetylation is a molecular switch in the regulation of MDM2 substrate specificity, revealing further insight into the posttranslational regulation of the MDM2/p53 cell survival axis. ..
  42. Sosulski M, Gongora R, Feghali Bostwick C, Lasky J, Sanchez C. Sirtuin 3 Deregulation Promotes Pulmonary Fibrosis. J Gerontol A Biol Sci Med Sci. 2017;72:595-602 pubmed publisher
    ..Sirtuin 3 (SIRT3) is a mitochondrial protein deacetylase regulator of antioxidant response and mitochondrial homeostasis...
  43. Guo X, Yan F, Shan X, Li J, Yang Y, Zhang J, et al. SIRT3 inhibits Ang II-induced transdifferentiation of cardiac fibroblasts through ?-catenin/PPAR-? signaling. Life Sci. 2017;186:111-117 pubmed publisher
    ..Sirtuin3 (SIRT3) has been believed to protect against cardiac fibrosis...
  44. Pagans S, Pedal A, North B, Kaehlcke K, Marshall B, Dorr A, et al. SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol. 2005;3:e41 pubmed
    ..These results support a model in which cycles of Tat acetylation and deacetylation regulate HIV transcription. SIRT1 recycles Tat to its unacetylated form and acts as a transcriptional coactivator during Tat transactivation. ..
  45. Kwon S, Seok S, Yau P, Li X, Kemper B, Kemper J. Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3. J Biol Chem. 2017;292:17312-17323 pubmed publisher
    Sirtuin 3 (SIRT3) deacetylates and regulates many mitochondrial proteins to maintain health, but its functions are depressed in aging and obesity...
  46. Yamamoto H, Schoonjans K, Auwerx J. Sirtuin functions in health and disease. Mol Endocrinol. 2007;21:1745-55 pubmed
    ..Here, we review some of the recent data related to the sirtuins and discuss their mode of action, their biological role in cellular and organismal models, and their possible association to age-related human diseases. ..
  47. Spadari R, Cavadas C, de Carvalho A, Ortolani D, de Moura A, Vassalo P. Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress. Cell Mol Neurobiol. 2018;38:109-120 pubmed publisher
    ..In the heart, SIRT1, SIRT3, and ?2-ARs are crucial to the regulation of the cardiomyocyte energy metabolism, oxidative stress, ..
  48. Wang X, Wang D, Luo Y, Myakala K, Dobrinskikh E, Rosenberg A, et al. FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity. J Am Soc Nephrol. 2018;29:118-137 pubmed publisher
    ..These results identify the renal signaling pathways regulated by FXR and TGR5, which may be promising targets for the treatment of nephropathy in diabetes and obesity. ..
  49. Della Morte D, Dong C, Bartels S, Cabral D, Blanton S, Sacco R, et al. Association of the sirtuin and mitochondrial uncoupling protein genes with carotid intima-media thickness. Transl Res. 2012;160:389-90 pubmed publisher
  50. Tao L, Park J, Lambert J. Differential prooxidative effects of the green tea polyphenol, (-)-epigallocatechin-3-gallate, in normal and oral cancer cells are related to differences in sirtuin 3 signaling. Mol Nutr Food Res. 2015;59:203-11 pubmed publisher
    ..Here, we report that these differential prooxidative effects are associated with sirtuin 3 (SIRT3), an important mitochondrial redox modulator...
  51. Wang J, Yi Y, Li Y, Cai X, He H, Ni X, et al. Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection. BMC Cancer. 2014;14:297 pubmed publisher
    Sirtuin 3 (Sirt3), one of the seven Sirtuins family members, plays critical roles in the progression of multiple cancer types...
  52. Yu F, Xu Q, Wu D, Lau A, Xu Y. The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers. PLoS ONE. 2016;11:e0159801 pubmed publisher
    Sirtuin-3 (SIRT3) is a major mitochondrial NAD(+)-dependent deacetylase and plays a key role in the progression and development of human cancers...