SIRT2

Summary

Gene Symbol: SIRT2
Description: sirtuin 2
Alias: SIR2, SIR2L, SIR2L2, NAD-dependent protein deacetylase sirtuin-2, NAD-dependent deacetylase sirtuin-2, SIR2-like protein 2, regulatory protein SIR2 homolog 2, silent information regulator 2, sir2-related protein type 2, sirtuin type 2
Species: human
Products:     SIRT2

Top Publications

  1. North B, Marshall B, Borra M, Denu J, Verdin E. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell. 2003;11:437-44 pubmed
    The silent information regulator 2 protein (Sir2p) of Saccharomyces cerevisiae is an NAD-dependent histone deacetylase that plays a critical role in transcriptional silencing...
  2. Hiratsuka M, Inoue T, Toda T, Kimura N, Shirayoshi Y, Kamitani H, et al. Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. Biochem Biophys Res Commun. 2003;309:558-66 pubmed
    ..We then focused on the cytoskeleton-related protein, SIRT2 (sirtuin homologue 2) tubulin deacetylase, which was down-regulated in gliomas. SIRT2 is located at 19q13...
  3. Zhao Y, Yang J, Liao W, Liu X, Zhang H, Wang S, et al. Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat Cell Biol. 2010;12:665-75 pubmed publisher
    ..In response to stress, FoxO1 was acetylated by dissociation from sirtuin-2 (SIRT2), a NAD(+)-dependent histone deacetylase, and the acetylated FoxO1 bound to Atg7, an E1-like protein, to influence ..
  4. Afshar G, Murnane J. Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2. Gene. 1999;234:161-8 pubmed
    ..In the present study, the complete sequence of a human gene, SIR2L, with homology to the yeast SIR2 gene is presented...
  5. Borra M, Langer M, Slama J, Denu J. Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases. Biochemistry. 2004;43:9877-87 pubmed
    The Silent information regulator 2 (Sir2) family of enzymes consists of NAD(+)-dependent histone/protein deacetylases that tightly couple the hydrolysis of NAD(+) and the deacetylation of an acetylated substrate to form nicotinamide, the ..
  6. North B, Rosenberg M, Jeganathan K, Hafner A, Michan S, Dai J, et al. SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. EMBO J. 2014;33:1438-53 pubmed publisher
    ..Here, we show that the loss of BubR1 levels with age is due to a decline in NAD(+) and the ability of SIRT2 to maintain lysine-668 of BubR1 in a deacetylated state, which is counteracted by the acetyltransferase CBP...
  7. Inoue T, Hiratsuka M, Osaki M, Yamada H, Kishimoto I, Yamaguchi S, et al. SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress. Oncogene. 2007;26:945-57 pubmed
    We previously identified SIRT2, an nicotinamide adenine dinucleotide (NAD)-dependent tubulin deacetylase, as a protein downregulated in gliomas and glioma cell lines, which are characterized by aneuploidy...
  8. Serrano L, Martínez Redondo P, Marazuela Duque A, Vazquez B, Dooley S, Voigt P, et al. The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation. Genes Dev. 2013;27:639-53 pubmed publisher
    ..However, the mechanisms involved in the regulation of this event are not well understood. Here we show that SirT2 regulates H4K20me1 deposition through the deacetylation of H4K16Ac (acetylation of H4K16) and determines the ..
  9. Beirowski B, Gustin J, Armour S, Yamamoto H, Viader A, North B, et al. Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A. 2011;108:E952-61 pubmed publisher
    ..to examine peripheral nerve myelination and identified the NAD(+)-dependent deacetylase Sir-two-homolog 2 (Sirt2) as a protein likely to be involved in myelination...

More Information

Publications69

  1. Schwer B, Verdin E. Conserved metabolic regulatory functions of sirtuins. Cell Metab. 2008;7:104-12 pubmed publisher
    b>Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases/mono-ADP-ribosyltransferases found in organisms ranging from bacteria to humans...
  2. Bae N, Swanson M, Vassilev A, Howard B. Human histone deacetylase SIRT2 interacts with the homeobox transcription factor HOXA10. J Biochem. 2004;135:695-700 pubmed
    ..Currently, there is no report on the interacting protein partner of a human Sir2 homolog, SIRT2. Here we show for the first time that SIRT2 interacts with the homeobox transcription factor, HOXA10, which was ..
  3. Frye R. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun. 2000;273:793-8 pubmed
    ..The seven human sirtuin genes include all four classes: SIRT1, SIRT2, and SIRT3 are class I, SIRT4 is class II, SIRT5 is class III, and SIRT6 and SIRT7 are class IV.
  4. North B, Verdin E. Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation. J Biol Chem. 2007;282:19546-55 pubmed
    ..Here, we demonstrate that SIRT2 is phosphorylated both in vitro and in vivo on serine 368 by the cell-cycle regulator, cyclin-dependent kinase 1, ..
  5. Borra M, O Neill F, Jackson M, Marshall B, Verdin E, Foltz K, et al. Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases. J Biol Chem. 2002;277:12632-41 pubmed
    b>Silent information regulator 2 (Sir2) family of enzymes has been implicated in many cellular processes that include histone deacetylation, gene silencing, chromosomal stability, and aging...
  6. Dryden S, Nahhas F, Nowak J, Goustin A, Tainsky M. Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Mol Cell Biol. 2003;23:3173-85 pubmed
    ..Our functional studies of human SIRT2, a homolog of the product of the yeast SIR2 gene, indicate that it plays a role in mitosis...
  7. Fulco M, Schiltz R, Iezzi S, King M, Zhao P, Kashiwaya Y, et al. Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol Cell. 2003;12:51-62 pubmed
    b>Sir2 is a NAD(+)-dependent histone deacetylase that controls gene silencing, cell cycle, DNA damage repair, and life span...
  8. Finnin M, Donigian J, Pavletich N. Structure of the histone deacetylase SIRT2. Nat Struct Biol. 2001;8:621-5 pubmed
    ..The 1.7 A crystal structure of the 323 amino acid catalytic core of human SIRT2, a homolog of yeast Sir2, reveals an NAD-binding domain, which is a variant of the Rossmann fold, and a smaller ..
  9. Inoue T, Nakayama Y, Yamada H, Li Y, Yamaguchi S, Osaki M, et al. SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest. Cell Cycle. 2009;8:1279-91 pubmed
    We previously identified SIRT2, a deacetylase for tubulin and histone H4, as a protein downregulated in gliomas, and reported that exogenously-expressed SIRT2 arrests the cell cycle prior to entry into mitosis to prevent chromosomal ..
  10. Voelter Mahlknecht S, Ho A, Mahlknecht U. FISH-mapping and genomic organization of the NAD-dependent histone deacetylase gene, Sirtuin 2 (Sirt2). Int J Oncol. 2005;27:1187-96 pubmed
    ..2 (SIRT2) is a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase, which belongs to the Silent information regulator 2 (Sir2) family of sirtuin histone deacetylases (HDACs)...
  11. Liu P, Xu N, Malyukova A, Scarlett C, Sun Y, Zhang X, et al. The histone deacetylase SIRT2 stabilizes Myc oncoproteins. Cell Death Differ. 2013;20:503-14 pubmed publisher
    ..Here we demonstrated that the class III histone deacetylase SIRT2 was upregulated by N-Myc in neuroblastoma cells and by c-Myc in pancreatic cancer cells, and that SIRT2 enhanced N-..
  12. North B, Verdin E. Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS ONE. 2007;2:e784 pubmed
    The human NAD+-dependent protein deacetylase SIRT2 resides predominantly in the cytoplasm where it functions as a tubulin deacetylase...
  13. Krishnan J, Danzer C, Simka T, Ukropec J, Walter K, Kumpf S, et al. Dietary obesity-associated Hif1? activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system. Genes Dev. 2012;26:259-70 pubmed publisher
    ..Hif1? is linked to its capacity to suppress ?-oxidation, in part, through transcriptional repression of sirtuin 2 (Sirt2) NAD(+)-dependent deacetylase...
  14. Frye R. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem Biophys Res Commun. 1999;260:273-9 pubmed
    ..Recombinant E. coli cobB and human SIRT2 sirtuin proteins were able to cause radioactivity to be transferred from [32P]NAD to bovine serum albumin (BSA)...
  15. Kim H, Vassilopoulos A, Wang R, Lahusen T, Xiao Z, Xu X, et al. SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell. 2011;20:487-99 pubmed publisher
    ..To investigate the physiological functions of SIRT2 in development and tumorigenesis, we disrupted Sirt2 in mice...
  16. Eskandarian H, Impens F, Nahori M, Soubigou G, Coppee J, Cossart P, et al. A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection. Science. 2013;341:1238858 pubmed publisher
    ..We found that during infection with the bacterium Listeria monocytogenes, the host deacetylase sirtuin 2 (SIRT2) translocates to the nucleus, in a manner dependent on the bacterial factor InlB...
  17. Yang M, Laurent G, Bause A, Spang R, German N, Haigis M, et al. HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS. Mol Cancer Res. 2013;11:1072-7 pubmed publisher
    ..Here, the deacetylases HDAC6 and SIRT2 were shown to regulate the acetylation state of K-RAS in cancer cells...
  18. Vaquero A, Scher M, Lee D, Sutton A, Cheng H, Alt F, et al. SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev. 2006;20:1256-61 pubmed
    The mammalian cytoplasmic protein SirT2 is a member of the Sir2 family of NAD+-dependent protein deacetylases involved in caloric restriction-dependent life span extension...
  19. Tatone C, Di Emidio G, Barbonetti A, Carta G, Luciano A, Falone S, et al. Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility. Hum Reprod Update. 2018;24:267-289 pubmed publisher
    ..Biochemical modulation of Sirtuin activity has led to discoveries of the roles of SIRT1, SIRT2, SIRT3 and SIRT6 in improving the competence of oocytes grown or matured in vitro in humans and animal models...
  20. Ribeiro Júnior G, de Souza Xavier Costa N, Belotti L, Dos Santos Alemany A, Amato Lourenço L, da Cunha P, et al. Diesel exhaust exposure intensifies inflammatory and structural changes associated with lung aging in mice. Ecotoxicol Environ Saf. 2019;170:314-323 pubmed publisher
    ..Antioxidant enzyme activity was evaluated by spectrophotometry, sirtuin 1 (SIRT1), sirtuin 2 (SIRT2) and sirtuin 6 (SIRT6) expression was assessed by reverse transcription polymerase chain reaction (RT-PCR), and ..
  21. Matsushima S, Sadoshima J. The role of sirtuins in cardiac disease. Am J Physiol Heart Circ Physiol. 2015;309:H1375-89 pubmed publisher
    ..Downregulation of Sirt2 is protective against ischemic-reperfusion injury...
  22. Etchegaray J, Zhong L, Mostoslavsky R. The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease. Curr Top Med Chem. 2013;13:2991-3000 pubmed
    ..Evocative of its ancestor, yeast Sir2, SIRT6 has the ability to increase lifespan in mice...
  23. Dong H, Yang S, Zhao Q, Han H, Zhu S, Zhu X, et al. Molecular characterization and protective efficacy of silent information regulator 2A from Eimeria tenella. Parasit Vectors. 2016;9:602 pubmed
    b>Silent information regulator 2 (SIR2) proteins are a family of NAD?+?-dependent protein deacetylases that are considered potential targets for anti-parasitic agents...
  24. Arab Sadeghabadi Z, Nourbakhsh M, Pasalar P, Emamgholipour S, Golestani A, Larijani B, et al. Reduced gene expression of sirtuins and active AMPK levels in children and adolescents with obesity and insulin resistance. Obes Res Clin Pract. 2018;12:167-173 pubmed publisher
    Sirtuins, including SIRT1 and SIRT2, are longevity-associated deacetylase enzymes that modulate metabolic homeostasis in response to the cellular energy state...
  25. Luo H, Zhou M, Ji K, Zhuang J, Dang W, Fu S, et al. Expression of Sirtuins in the Retinal Neurons of Mice, Rats, and Humans. Front Aging Neurosci. 2017;9:366 pubmed publisher
    ..SIRT1 is highly expressed in mouse, rat, and human retinas, whereas SIRT2-7 expression was relatively lower in human retinas...
  26. Yang Y, Ding J, Gao Z, Wang Z. A variant in SIRT2 gene 3'-UTR is associated with susceptibility to colorectal cancer. Oncotarget. 2017;8:41021-41025 pubmed publisher
    b>SIRT2 is a member of sirtuin family and is associated with cell growth in various cancers...
  27. Weiser B, Eckenhoff R. Propofol inhibits SIRT2 deacetylase through a conformation-specific, allosteric site. J Biol Chem. 2015;290:8559-68 pubmed publisher
    ..We photolabeled a myelin-enriched fraction from rat brain with [(3)H]AziPm and identified the sirtuin deacetylase SIRT2 as a target of the anesthetic...
  28. Hageman J, Rujano M, van Waarde M, Kakkar V, Dirks R, Govorukhina N, et al. A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation. Mol Cell. 2010;37:355-69 pubmed publisher
    ..binding, formation of polydisperse oligomeric complexes, and interaction with histone deacetylases (HDAC4, HDAC6, SIRT2). Inhibiting HDAC4 reduced DNAJB8 function...
  29. Kim W, Lee J, Quan C, Youn H, Kim H, Bae S. Nicotinamide inhibits growth of carcinogen induced mouse bladder tumor and human bladder tumor xenograft through up-regulation of RUNX3 and p300. J Urol. 2011;185:2366-75 pubmed publisher
    ..Results suggest that nicotinamide has preventive and therapeutic effects on tumorigenesis through multiple mechanisms of RUNX3 expression up-regulation. ..
  30. Suematsu T, Li Y, Kojima H, Nakajima K, Oshimura M, Inoue T. Deacetylation of the mitotic checkpoint protein BubR1 at lysine 250 by SIRT2 and subsequent effects on BubR1 degradation during the prometaphase/anaphase transition. Biochem Biophys Res Commun. 2014;453:588-94 pubmed publisher
    ..We previously reported that downregulation of SIRT2, a member of the sirtuin family of NAD+-dependent deacetylases, confers resistance to microtubule inhibitors by ..
  31. Zhang Z, Zhang P, Qi G, Jiao F, Wang Q, Yan J, et al. CDK5-mediated phosphorylation of Sirt2 contributes to depressive-like behavior induced by social defeat stress. Biochim Biophys Acta Mol Basis Dis. 2018;1864:533-541 pubmed publisher
    ..Histone deacetylases (HDACs) appear to play an essential role in depression. As the class III HDACs, Sirt1 and Sirt2 have attracted the most interest in the nervous system...
  32. van der Horst A, Tertoolen L, de Vries Smits L, Frye R, Medema R, Burgering B. FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J Biol Chem. 2004;279:28873-9 pubmed
    ..These data demonstrate that acetylation functions in a second pathway of negative control for FOXO factors and provides a novel mechanism whereby hSir2(SIRT1) can promote cellular survival and increase lifespan. ..
  33. Zhang B, Xu D, She L, Wang Z, Yang N, Sun R, et al. Silybin inhibits NLRP3 inflammasome assembly through the NAD+/SIRT2 pathway in mice with nonalcoholic fatty liver disease. FASEB J. 2018;32:757-767 pubmed publisher
    ..Both MEC-17 and sirtuin 2 (SIRT2) were influenced by palmitate and silybin, whereas histone deacetylase 6 was not affected...
  34. Cui Y, Li X, Lin J, Hao Q, Li X. Histone Ketoamide Adduction by 4-Oxo-2-nonenal Is a Reversible Posttranslational Modification Regulated by Sirt2. ACS Chem Biol. 2017;12:47-51 pubmed publisher
    ..Here, we report that human Sirt2 catalyzes the removal of histone Kgon...
  35. Singh S, Kumar P, Thakur S, Kiran S, Sen B, Sharma S, et al. Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells. Tumour Biol. 2015;36:6159-71 pubmed publisher
    ..Therefore, in the present study, the expression of SIRT1, SIRT2, and SIRT7 during different stages of cervical cancer progression was analyzed...
  36. Bartosch C, Monteiro Reis S, Almeida Rios D, Vieira R, Castro A, Moutinho M, et al. Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium. Oncotarget. 2016;7:1144-54 pubmed publisher
    ..Compared to NNE, ECs showed SIRT7 (p < 0.001) mRNA overexpression, whereas SIRT1 (p < 0.001), SIRT2 (p < 0.001), SIRT4 (p < 0.001) and SIRT5 (p < 0.001) were underexpressed...
  37. Cheng S, Ren J, Cai X, Jiang H, Chen J. HBx-elevated SIRT2 promotes HBV replication and hepatocarcinogenesis. Biochem Biophys Res Commun. 2018;496:904-910 pubmed publisher
    Sirtuin 2 (SIRT2) is a class III histone deacetylase that has been implicated to promote HCC development. However, the functional role of SIRT2 in HBV is still unclear. In this study, we found that HBV could upregulate SIRT2 expression...
  38. Saxena M, Dykes S, Malyarchuk S, Wang A, Cardelli J, Pruitt K. The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration. Oncogene. 2015;34:188-98 pubmed publisher
    ..Similarly, SIRT2 has been demonstrated to be upregulated in some cancers; however, studies have also reported its role in tumor ..
  39. Zhang H, Head P, Daddacha W, Park S, Li X, Pan Y, et al. ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA. Cell Rep. 2016;14:1435-1447 pubmed publisher
    ..and Rad3-related (ATR) kinase checkpoint pathway maintains genome integrity; however, the role of the sirtuin 2 (SIRT2) acetylome in regulating this pathway is not clear...
  40. Cao W, Hong Y, Chen H, Wu F, Wei X, Ying W. SIRT2 mediates NADH-induced increases in Nrf2, GCL, and glutathione by modulating Akt phosphorylation in PC12 cells. FEBS Lett. 2016;590:2241-55 pubmed publisher
    b>SIRT2 plays important roles in multiple biological processes. It is unclear whether SIRT2 affects antioxidant capacity by modulating Nrf2, a key transcription factor for multiple antioxidant genes...
  41. Xia M, Yu J, Miao D, Lu R, Zheng X, Tan L. SIRT2 polymorphism rs10410544 is associated with Alzheimer's disease in a Han Chinese population. J Neurol Sci. 2014;336:48-51 pubmed publisher
    Sirtuin 2 (SIRT2) is a strong protein deacetylase, which is highly expressed in central nervous system...
  42. Liu M, Xu P, Guan Z, Qian X, Dockery P, FitzGerald U, et al. Ulk4 deficiency leads to hypomyelination in mice. Glia. 2018;66:175-190 pubmed publisher
    ..Expression of stage-specific oligodendrocyte factors including Cspg4, Sox17, Nfasc, Enpp6, Sirt2, Cnp, Plp1, Mbp, Ugt8, Mag and Mog are markedly decreased...
  43. Skoge R, Dölle C, Ziegler M. Regulation of SIRT2-dependent ?-tubulin deacetylation by cellular NAD levels. DNA Repair (Amst). 2014;23:33-8 pubmed publisher
    ..can be reversed by either the NAD-independent class II histone deacetylase HDAC6 or the NAD-dependent deacetylase SIRT2. In this study, we assessed to what extent cellular NAD levels are involved in the regulation of the ?-tubulin ..
  44. Yu D, Jung S, An H, Lee S, Hong J, Park J, et al. Caveolin-1 deficiency induces premature senescence with mitochondrial dysfunction. Aging Cell. 2017;16:773-784 pubmed publisher
    ..From these results, we concluded that Cav-1 deficiency induces premature senescence via mitochondrial dysfunction and silent information regulator 2 homologue 1 (SIRT1) inactivation.
  45. Li Y, Dai D, Lu Q, Fei M, Li M, Wu X. Sirt2 suppresses glioma cell growth through targeting NF-?B-miR-21 axis. Biochem Biophys Res Commun. 2013;441:661-7 pubmed publisher
    ..Here we report that Sir2 was under expressed in human glioma tissues and cell lines. We found that Sirt2 overexpression decreased cell proliferation and colony formation capacity...
  46. Kuhlmann N, Chollet C, Baldus L, Neundorf I, Lammers M. Development of Substrate-Derived Sirtuin Inhibitors with Potential Anticancer Activity. ChemMedChem. 2017;12:1703-1714 pubmed publisher
    ..Herein we show that K52-acetylated RhoGDIα is specifically deacetylated by the sirtuin deacetylase Sirt2. We show that acetylation at K52 decelerates cervical cancer cell proliferation, suggesting RhoGDIα acetylation ..
  47. Zhou Y, Cui H, Yu X, Peng T, Wang G, Wen X, et al. Synthesis and Evaluation of Novel Benzofuran Derivatives as Selective SIRT2 Inhibitors. Molecules. 2017;22: pubmed publisher
    ..The enzymatic assay showed that all the compounds showed certain anti-SIRT2 activity and selective over SIRT1 and SIRT3 with IC50 (half maximal inhibitory concentration) values at ..
  48. Thurtle Schmidt D, Dodson A, Rine J. Histone Deacetylases with Antagonistic Roles in Saccharomyces cerevisiae Heterochromatin Formation. Genetics. 2016;204:177-90 pubmed publisher
    As the only catalytic member of the Sir-protein gene-silencing complex, Sir2's catalytic activity is necessary for silencing...
  49. Pramanik K, Fofaria N, Gupta P, Srivastava S. CBP-mediated FOXO-1 acetylation inhibits pancreatic tumor growth by targeting SirT. Mol Cancer Ther. 2014;13:687-98 pubmed publisher
    ..Taken together, our results suggest that capsaicin activated JNK and FOXO-1, leading to the acetylation of FOXO-1 through CBP and SirT-1. Acetylated FOXO1 induced apoptosis in pancreatic cancer cells through BIM activation. ..
  50. Nahhas F, Dryden S, Abrams J, Tainsky M. Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin. Mol Cell Biochem. 2007;303:221-30 pubmed
    Human SIRT2 is a cytoplasmic NAD-dependent deacetylase implicated in the mitotic regulation of microtubule dynamics by its association with the class II histone deacetylase 6 (HDAC6)...
  51. Xu D, Farmer A, Collett G, Grishin N, Chook Y. Sequence and structural analyses of nuclear export signals in the NESdb database. Mol Biol Cell. 2012;23:3677-93 pubmed publisher
    ..Finally, we also tested CRM1-binding of 40 NESs that were found in the 56 structures. We found that 16 of the NES peptides did not bind CRM1, hence illustrating how NESs are easily misidentified...
  52. Rothgiesser K, Erener S, Waibel S, Luscher B, Hottiger M. SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310. J Cell Sci. 2010;123:4251-8 pubmed publisher
    ..In this study, we identified SIRT2 as a deacetylase of the transcription factor p65...
  53. Anwar T, Khosla S, Ramakrishna G. Increased expression of SIRT2 is a novel marker of cellular senescence and is dependent on wild type p53 status. Cell Cycle. 2016;15:1883-97 pubmed publisher
    ..In the present study, we now report upregulation of SIRT2 as a specific feature associated with stress induced premature senescence but not with either quiescence or cell ..
  54. Yang W, Gao F, Zhang P, Pang S, Cui Y, Liu L, et al. Functional genetic variants within the SIRT2 gene promoter in acute myocardial infarction. PLoS ONE. 2017;12:e0176245 pubmed publisher
    ..Low frequent and rare genetic variants have been recently proposed to be main causes for CAD. SIRT2 is a member of sirtuin family, NAD(+)-dependent class III deacetylases...
  55. Black J, Mosley A, Kitada T, Washburn M, Carey M. The SIRT2 deacetylase regulates autoacetylation of p300. Mol Cell. 2008;32:449-55 pubmed publisher
    ..We found that the NAD(+)-dependent histone deacetylase SIRT2 deacetylates p300 in vitro and in cells...
  56. Liu B, Lin Y, Darwanto A, Song X, Xu G, Zhang K. Identification and characterization of propionylation at histone H3 lysine 23 in mammalian cells. J Biol Chem. 2009;284:32288-95 pubmed publisher
    ..that histone acetyltransferase p300 can catalyze H3 Lys(23) propionylation, whereas histone deacetylase Sir2 can remove this modification in the presence of NAD(+)...
  57. Gomes P, Outeiro T, Cavadas C. Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism. Trends Pharmacol Sci. 2015;36:756-68 pubmed publisher
    ..b>SIRT2, the predominantly cytosolic sirtuin, is among the least understood of the seven mammalian sirtuin isoforms ..
  58. Gal J, Bang Y, Choi H. SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition. Neurochem Int. 2012;61:992-1000 pubmed publisher
    ..Sirtuin-2 (SIRT2) is a class III histone deacetylase that is expressed abundantly in aging brain tissue...
  59. Porcelli S, Salfi R, Politis A, Atti A, Albani D, Chierchia A, et al. Association between Sirtuin 2 gene rs10410544 polymorphism and depression in Alzheimer's disease in two independent European samples. J Neural Transm (Vienna). 2013;120:1709-15 pubmed publisher
    ..Particularly SIRT2 gene has been associated with Alzheimer's disease (AD) as well as with mood disorders...
  60. Rack J, Vanlinden M, Lutter T, Aasland R, Ziegler M. Constitutive nuclear localization of an alternatively spliced sirtuin-2 isoform. J Mol Biol. 2014;426:1677-91 pubmed publisher
    Sirtuin-2 (SIRT2), the cytoplasmic member of the sirtuin family, has been implicated in the deacetylation of nuclear proteins...