SIL1

Summary

Gene Symbol: SIL1
Description: SIL1 nucleotide exchange factor
Alias: BAP, MSS, ULG5, nucleotide exchange factor SIL1, BiP-associated protein, SIL1 homolog, endoplasmic reticulum chaperone, SIL1-like protein endoplasmic reticulum chaperone
Species: human
Products:     SIL1

Top Publications

  1. Anttonen A, Siintola E, Tranebjaerg L, Iwata N, Bijlsma E, Meguro H, et al. Novel SIL1 mutations and exclusion of functional candidate genes in Marinesco-Sjögren syndrome. Eur J Hum Genet. 2008;16:961-9 pubmed publisher
    ..Recently, mutations in the SIL1 gene, which encodes an endoplasmic reticulum (ER) resident cochaperone, were identified as a major cause of MSS...
  2. Senderek J, Krieger M, Stendel C, Bergmann C, Moser M, Breitbach Faller N, et al. Mutations in SIL1 cause Marinesco-Sjögren syndrome, a cerebellar ataxia with cataract and myopathy. Nat Genet. 2005;37:1312-4 pubmed
    b>SIL1 (also called BAP) acts as a nucleotide exchange factor for the Hsp70 chaperone BiP (also called GRP78), which is a key regulator of the main functions of the endoplasmic reticulum...
  3. Tyson J, Stirling C. LHS1 and SIL1 provide a lumenal function that is essential for protein translocation into the endoplasmic reticulum. EMBO J. 2000;19:6440-52 pubmed
    ..In addition, we have identified a UPR- regulated gene, SIL1, whose overexpression is sufficient to suppress the Deltaire1Deltalhs1 growth defect...
  4. Chung K, Shen Y, Hendershot L. BAP, a mammalian BiP-associated protein, is a nucleotide exchange factor that regulates the ATPase activity of BiP. J Biol Chem. 2002;277:47557-63 pubmed
    We identified a mammalian BiP-associated protein, BAP, using a yeast two-hybrid screen that shared low homology with yeast Sls1p/Sil1p and mammalian HspBP1, both of which regulate the ATPase activity of their Hsp70 partner...
  5. Karim M, Parsian A, Cleves M, Bracey J, Elsayed M, Elsobky E, et al. A novel mutation in BAP/SIL1 gene causes Marinesco-Sjögren syndrome in an extended pedigree. Clin Genet. 2006;70:420-3 pubmed
  6. Eriguchi M, Mizuta H, Kurohara K, Fujitake J, Kuroda Y. Identification of a new homozygous frameshift insertion mutation in the SIL1 gene in 3 Japanese patients with Marinesco-Sjögren syndrome. J Neurol Sci. 2008;270:197-200 pubmed publisher
    ..Recently, mutations in the SIL1 gene on chromosome 5q31 have been shown to be a cause of MSS...
  7. Riazuddin S, Amiri Kordestani L, Kaul H, Butt T, Jiao X, Riazuddin S, et al. Novel SIL1 mutations in consanguineous Pakistani families mapping to chromosomes 5q31. Mol Vis. 2009;15:1050-6 pubmed
    ..Coding exons, exon-intron boundaries, 5' UTR, and 3' UTR of the candidate gene SIL1 residing in the linkage interval was sequenced bi-directionally...
  8. Howes J, Shimizu Y, Feige M, Hendershot L. C-terminal mutations destabilize SIL1/BAP and can cause Marinesco-Sjögren syndrome. J Biol Chem. 2012;287:8552-60 pubmed publisher
    ..Recently, mutations in the endoplasmic reticulum (ER)-associated co-chaperone SIL1/BAP were identified to be the major cause of MSS...
  9. Anttonen A, Mahjneh I, Hämäläinen R, Lagier Tourenne C, Kopra O, Waris L, et al. The gene disrupted in Marinesco-Sjögren syndrome encodes SIL1, an HSPA5 cochaperone. Nat Genet. 2005;37:1309-11 pubmed
    ..We identified four disease-associated, predicted loss-of-function mutations in SIL1, which encodes a nucleotide exchange factor for the heat-shock protein 70 (HSP70) chaperone HSPA5...

More Information

Publications133 found, 100 shown here

  1. Takahata T, Yamada K, Yamada Y, Ono S, Kinoshita A, Matsuzaka T, et al. Novel mutations in the SIL1 gene in a Japanese pedigree with the Marinesco-Sjögren syndrome. J Hum Genet. 2010;55:142-6 pubmed publisher
    Marinesco-Sjögren syndrome (MSS) is a rare autosomal recessive disorder. Mutation in the SIL1 gene accounts for the majority of MSS cases. However, some individuals with typical MSS without SIL1 mutations have been reported...
  2. Lagier Tourenne C, Tranebaerg L, Chaigne D, Gribaa M, Dollfus H, Silvestri G, et al. Homozygosity mapping of Marinesco-Sjögren syndrome to 5q31. Eur J Hum Genet. 2003;11:770-8 pubmed
    Marinesco-Sjögren syndrome (MSS), first described in 1931, is an autosomal recessive condition characterised by somatic and mental retardation, congenital cataracts and cerebellar ataxia...
  3. Smerdová L, Šmerdová J, Kabátková M, Kohoutek J, Blažek D, Machala M, et al. Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway. Carcinogenesis. 2014;35:2534-43 pubmed publisher
    ..and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells...
  4. Barrack M, Van Loan M, Rauh M, Nichols J. Physiologic and behavioral indicators of energy deficiency in female adolescent runners with elevated bone turnover. Am J Clin Nutr. 2010;92:652-9 pubmed publisher
    ..parathyroid hormone, progesterone, triiodothyronine, 25-hydroxycholecalciferol, bone-specific alkaline phosphatase (BAP), and cross-linked C-telopeptides of type I collagen (CTX); an evaluation of height, weight, bone mass, and body ..
  5. Laknaur A, Foster T, Bobb L, Ramesh A, Ladson G, Hood D, et al. Altered expression of histone deacetylases, inflammatory cytokines and contractile-associated factors in uterine myometrium of Long Evans rats gestationally exposed to benzo[a]pyrene. J Appl Toxicol. 2016;36:827-35 pubmed publisher
    ..However, there are no studies on the role of benzo[a]pyrene (BaP), an environmental toxicant, in the incidence of PTB...
  6. Zapletal O, Tylichová Z, Neca J, Kohoutek J, Machala M, Milcova A, et al. Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models. Arch Toxicol. 2017;91:2135-2150 pubmed publisher
    ..cytochrome P450 family 1 (CYP1) and on metabolism of carcinogenic polycyclic aromatic hydrocarbon, benzo[a]pyrene (BaP), in colon epithelial cells...
  7. Ravanpay A, Barkley A, White Dzuro G, Cimino P, Gonzalez Cuyar L, Lockwood C, et al. Giant Pediatric Rhabdoid Meningioma Associated with a Germline BAP1 Pathogenic Variation: A Rare Clinical Case. World Neurosurg. 2018;119:402-415 pubmed publisher
    ..This tumor was discovered to have a biallelic loss of BAP-1 mutation and the patient was found to have a germline mutation in 1 of her BAP-1 alleles...
  8. Aslantas O, Demir C. Investigation of the antibiotic resistance and biofilm-forming ability of Staphylococcus aureus from subclinical bovine mastitis cases. J Dairy Sci. 2016;99:8607-8613 pubmed publisher
    ..5% of the isolates were found to be biofilm producers, respectively. The percentage rate of icaA, icaD, and bap genes in Staph. aureus isolates were 86.6, 86.6, and 13.4%, respectively...
  9. Gao D, Lin J, Ou K, Chen Y, Li H, Dai Q, et al. Embryonic exposure to benzo(a)pyrene inhibits reproductive capability in adult female zebrafish and correlation with DNA methylation. Environ Pollut. 2018;240:403-411 pubmed publisher
    This study was conducted to investigate the effects of embryonic short-term exposure to benzo(a)pyrene (BaP), a model polycyclic aromatic hydrocarbon, on ovarian development and reproductive capability in adult female zebrafish...
  10. Han X, Li Q, Shen L, Hu D, Qu Y. [Correlation between the biofilm-forming ability, biofilm-related genes and antimicrobial resistance of Acinetobacter baumannii]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2014;26:639-43 pubmed publisher
    ..In addition, the expressions of biofilm-related gene Bap, bfs and intI1 were tested with polymerase chain reaction (PCR) assay...
  11. Granchi D, Caudarella R, Ripamonti C, Spinnato P, Bazzocchi A, Massa A, et al. Potassium Citrate Supplementation Decreases the Biochemical Markers of Bone Loss in a Group of Osteopenic Women: The Results of a Randomized, Double-Blind, Placebo-Controlled Pilot Study. Nutrients. 2018;10: pubmed publisher
    ..acid phosphatase 5b (TRACP5b), carboxy-terminal telopeptide of type I collagen (CTX), bone alkaline phosphatase (BAP), procollagen type 1 N terminal propeptide (PINP)), and urine pH, electrolytes, and citrate were measured...
  12. Pandey H, Talukdar A, Gangte J, Gupta S, Chandra N. Cholesterol homeostasis and cell proliferation by mitogenic homologs: insulin, benzo-α-pyrene and UV radiation. Cell Biol Toxicol. 2018;34:305-319 pubmed publisher
    ..We observed that insulin and benzo-α-pyrene (BaP) induced the expression of Low-Density Lipoprotein receptor (LDLR) on HepG2 cells, thereby enhancing the uptake of ..
  13. Cai M, Hu R, Zhang K, Ma S, Zheng L, Yu Z, et al. Resistance of black soldier fly (Diptera: Stratiomyidae) larvae to combined heavy metals and potential application in municipal sewage sludge treatment. Environ Sci Pollut Res Int. 2018;25:1559-1567 pubmed publisher
    Treating municipal sewage sludge (MSS) sustainably and economically in China remains a challenge because of risks associated with the heavy metals it contains. In this study, black solider fly larvae (BSFL) were used for MSS treatment...
  14. Kanazawa I, Tanaka S, Sugimoto T. The Association Between Osteocalcin and Chronic Inflammation in Patients with Type 2 Diabetes Mellitus. Calcif Tissue Int. 2018;103:599-605 pubmed publisher
    ..Bone-specific alkaline phosphatase (BAP), total osteocalcin (OC), undercarboxylated OC (ucOC), and urinary N-terminal cross-linked telopeptide of type-I ..
  15. Xu J, Li L, Wang Y, Li Y, Shan M, Sun S, et al. Hepatocyte-specific deletion of BAP31 promotes SREBP1C activation, promotes hepatic lipid accumulation, and worsens IR in mice. J Lipid Res. 2018;59:35-47 pubmed publisher
    Conditional knockout mice with targeted disruption of B-cell associated protein (BAP)31 in adult mouse liver were generated and challenged with a high-fat diet (HFD) for 36 or 96 days and markers of obesity, diabetes, and hepatic ..
  16. Almuhlafi M, Jamilah K, Almutairi A, Salam M. Relationship between early menarche, obesity, and disordered eating behaviors: a school-based cross-sectional survey in Northern Saudi Arabia. Diabetes Metab Syndr Obes. 2018;11:743-751 pubmed publisher
    ..Test-26 (EAT-26) were scored, summated, and then presented in percentage mean scores (PMSs) and mean scores (MSs). Sample comprised 399 participants. One hundred twenty-eight (32...
  17. Namba S, Yamaoka Tojo M, Kakizaki R, Nemoto T, Fujiyoshi K, Hashikata T, et al. Effects on bone metabolism markers and arterial stiffness by switching to rivaroxaban from warfarin in patients with atrial fibrillation. Heart Vessels. 2017;32:977-982 pubmed publisher
    ..Osteopontin (OPN), bone alkaline phosphatase (BAP), and under-carboxylated osteocalcin (ucOC) were measured...
  18. Zhao H, Huang Y, Tao J. ST1926 Attenuates Steroid-Induced Osteoporosis in Rats by Inhibiting Inflammation Response. J Cell Biochem. 2017;118:2072-2086 pubmed publisher
    ..In addition, alkaline phosphatase (ALP), osteoprotegerin (OPG), bone alkaline phosphatase (BAP) and bone morphogenic protein (BMP) expression in serum and cells were detected at protein or mRNA levels...
  19. Grochowalska A, Kozioł Montewka M, Sobieszczańska A. Analysis of Acinetobacter baumannii resistance patterns in patients with chronic obstructive pulmonary disease (COPD) in terms of choice of effective empiric antibiotic therapy. Ann Agric Environ Med. 2017;24:307-311 pubmed publisher
    ..diseases (COPD), who were admitted to the Pulmonology Ward of the Masovian Specialistic Hospital in Radom (MSS)...
  20. Chu Z, Li H, Sun S, Jiang Y, Wang B, Dong Y. Melatonin promotes osteoblast differentiation of bone marrow mesenchymal stem cells in aged rats. Eur Rev Med Pharmacol Sci. 2017;21:4446-4456 pubmed
    ..to detect bone microstructure and ELISA to detect the contents of osteocalcin (OCN) and bone alkaline phosphatase (BAP) in serum...
  21. Iatropoulos M, Kobets T, Duan J, Brunnemann K, Vock E, Deschl U, et al. Chicken egg fetal liver DNA and histopathologic effects of structurally diverse carcinogens and non-carcinogens. Exp Toxicol Pathol. 2017;69:533-546 pubmed publisher
    ..hepatocarcinogens: 2-acetylaminofluorene (AAF), aflatoxin B1 (AFB1), benzo[a]pyrene (BaP), diethylnitrosamine (DEN); four structurally related non- or weakly- carcinogenic comparators: fluorene (FLU), ..
  22. Zhao X, Liang J, Chen H, Liang Y, Guo H, Su Z, et al. Anti-Fatigue and Antioxidant Activity of the Polysaccharides Isolated from Millettiae speciosae Champ. Leguminosae. Nutrients. 2015;7:8657-69 pubmed publisher
    ..In this paper, we further separated MSE into total polysaccharides (MSP) and supernatant (MSS) by alcohol precipitation, and explored which fraction was active for its anti-fatigue effect...
  23. Zhou Z, Yang J, Chan K. Toxic effects of triclosan on a zebrafish (Danio rerio) liver cell line, ZFL. Aquat Toxicol. 2017;191:175-188 pubmed publisher
    ..is a weak P4501a (Cyp1a) agonist at 5?M and that it inhibits cytochrome Cyp1a activity induced by benzo(a)pyrene (BaP). In time course-based mRNA profiling in ZFL cells, 4-h exposure to TCS caused a significant (up to 37...
  24. Gdula Argasińska J, Czepiel J, Totoń Żurańska J, Wołkow P, Librowski T, Czapkiewicz A, et al. n-3 Fatty acids regulate the inflammatory-state related genes in the lung epithelial cells exposed to polycyclic aromatic hydrocarbons. Pharmacol Rep. 2016;68:319-28 pubmed publisher
    ..We analyzed the influence of DHA, EPA and/or benzo(a)pyrene (BaP), chrysene (Chr), fluoranthene (Flu) and benzo(a)anthracene (Baa) treatment on the fatty acids (FAs) profile and ..
  25. Pádua M, Santos R, Labory C, Stein V, Mendonça E, Alves E, et al. Histodifferentiation of oil palm somatic embryo development at low auxin concentration. Protoplasma. 2018;255:285-295 pubmed publisher
    ..25 mg L-1 NAA, 2 mg L-1 BAP, MM vitamins and 200 mg L-1 malt extract, and 100 mg L-1 casein hydrolysate) was the most ..
  26. Zhu C, Li T, Zhang P, Zou M, Guo Q, Qu X. Beneficial effects of low-level laser irradiation on senile osteoporosis in rats. Eur Rev Med Pharmacol Sci. 2017;21:5230-5238 pubmed publisher
    ..The contents of serum osteocalcin (OCN) and bone alkaline phosphatase (BAP) were measured by enzyme-linked immunosorbent assay (ELISA)...
  27. Kyvernitakis I, Saeger U, Ziller V, Bauer T, Seker Pektas B, Hadji P. The effect of age, sex hormones, and bone turnover markers on calcaneal quantitative ultrasonometry in healthy German men. J Clin Densitom. 2013;16:320-328 pubmed publisher
    ..05). Bone turnover markers present lower values gradually, and we found a significant correlation between carboxy-terminal collagen crosslinks (CTX), osteocalcin (OC), bone alkaline phosphatase (BAP), and QUS variables (p < 0.05).
  28. Spanu A, Solinas P, Babudieri S, Calia G, Lovigu C, Mannazzu M, et al. Different impact of NNRTI and PI-including HAART on bone mineral density loss in HIV-infected patients. Eur Rev Med Pharmacol Sci. 2015;19:4576-89 pubmed
    ..Serum bone alkaline phosphatase (BAP), by IRMA, and urine pyridinoline/deoxypyridinoline (PYD&DPD), by EIA, were also assayed in all cases...
  29. Sullivan D, Gad S, Laulicht B, Bakhru S, Steiner S. Nonclinical Safety Assessment of PER977: A Small Molecule Reversal Agent for New Oral Anticoagulants and Heparins. Int J Toxicol. 2015;34:308-17 pubmed publisher
    ..were conducted to evaluate the toxicity of PER977 and its primary metabolite, 1,4-bis(3-aminopropyl)piperazine (BAP). PER977 and BAP were negative for systemic toxicity in dogs and rats...
  30. Beal M, Gagne R, Williams A, Marchetti F, Yauk C. Characterizing Benzo[a]pyrene-induced lacZ mutation spectrum in transgenic mice using next-generation sequencing. BMC Genomics. 2015;16:812 pubmed publisher
    ..derived from the bone marrow DNA of six Muta™Mouse males exposed to the well-established mutagen benzo[a]pyrene (BaP) and six solvent-exposed controls...
  31. Karami A, Teh S, Zakaria M, Courtenay S. Ploidy-, gender-, and dose-dependent alteration of selected biomarkers in Clarias gariepinus treated with benzo[a]pyrene. J Environ Sci (China). 2015;38:95-102 pubmed publisher
    ..p.) injected with 0, 5 or 25mg/kg benzo[a]pyrene (BaP) and liver and gallbladder were sampled 48hr later...
  32. Karakousis G, Gimotty P, Bartlett E, Sim M, Neuwirth M, Fraker D, et al. Thin Melanoma with Nodal Involvement: Analysis of Demographic, Pathologic, and Treatment Factors with Regard to Prognosis. Ann Surg Oncol. 2017;24:952-959 pubmed publisher
    ..Uni- and multivariable analyses of melanoma-specific survival (MSS) were performed. At center 1, 427 CNR patients were compared with 91 SLN+ patients...
  33. Zhang Y, Zeng L, Yang J, Zheng X, Yu T. 6-Benzylaminopurine inhibits growth of Monilinia fructicola and induces defense-related mechanism in peach fruit. Food Chem. 2015;187:210-7 pubmed publisher
    This study demonstrated the inhibitory effect of 6-benzylaminopurine (BAP), the first generation synthetic cytokinin, on the invasion of Monilinia fructicola in peach fruit and the possible mechanism involved for the first time...
  34. Chong K, Thang L, Quirino J, See H. Monitoring of vancomycin in human plasma via portable microchip electrophoresis with contactless conductivity detector and multi-stacking strategy. J Chromatogr A. 2017;1485:142-146 pubmed publisher
    ..preconcentration technique based on field-enhanced sample injection (FESI) and micelle-to-solvent stacking (MSS) was developed and implemented in MCE-C4D system equipped with a commercially available double T-..
  35. Inui T, Anzai M, Takezawa Y, Endo W, Kakisaka Y, Kikuchi A, et al. A novel mutation in the proteolytic domain of LONP1 causes atypical CODAS syndrome. J Hum Genet. 2017;62:653-655 pubmed publisher
    ..features were not consistent with CODAS syndrome but overlapped with Marinesco-Sjögren syndrome, a multisystem disorder caused by a mutation in SIL1. An atypical mutation site may result in atypical presentation of the LONP1 mutation.
  36. Zhang L, Duan X, He N, Chen X, Shi J, Li W, et al. Exposure to lethal levels of benzo[a]pyrene or cadmium trigger distinct protein expression patterns in earthworms (Eisenia fetida). Sci Total Environ. 2017;595:733-742 pubmed publisher
    ..fetida to exposure to the 10% lethal concentration (14d-LC10) of benzo[a]pyrene (BaP) or cadmium (Cd) in natural red soil (China)...
  37. Scott D, Lovell R. Individualisation of speed thresholds does not enhance the dose-response determination in football training. J Sports Sci. 2017;:1-10 pubmed publisher
    ..to the heart rate deflection point, maximal aerobic speed, YYIR1 performance, and maximal sprint speed (MSS)...
  38. Galante J, Dufour G, Vainre M, Wagner A, Stochl J, Benton A, et al. A mindfulness-based intervention to increase resilience to stress in university students (the Mindful Student Study): a pragmatic randomised controlled trial. Lancet Public Health. 2018;3:e72-e81 pubmed publisher
    ..to receive either an 8 week mindfulness course adapted for university students (Mindfulness Skills for Students [MSS]) plus mental health support as usual, or mental health support as usual alone...
  39. Günay E, Celik S, Sarinc Ulasli S, Özyürek A, Hazman Ã, Günay S, et al. Comparison of the Anti-inflammatory Effects of Proanthocyanidin, Quercetin, and Damnacanthal on Benzo(a)pyrene Exposed A549 Alveolar Cell Line. Inflammation. 2016;39:744-51 pubmed publisher
    ..and oxidative stress parameters and to examine the viability of the A549 cell line treated with benzo(a)pyrene (BaP) in vitro...
  40. Corrigan D, Elliott J, Blair E, Reeves S, Schmüser I, Walton A, et al. Advances in electroanalysis, sensing and monitoring in molten salts. Faraday Discuss. 2016;190:351-66 pubmed publisher
    ..salt compatible microelectrodes (MSMs) enable prolonged quantitative microelectrode measurements in molten salts (MSs)...
  41. Aturki Z, Fanali S, Rocco A. Online sample concentration and analysis of drugs of abuse in human urine by micelle to solvent stacking in capillary zone electrophoresis. Electrophoresis. 2016;37:2875-2881 pubmed publisher
    ..An MSS (micelle to solvent stacking) approach was evaluated to enhance method sensitivity...
  42. Kim J, Hong Y, Kim H, Kim K, Kim S, Lim S, et al. Microsatellite Instability was not Associated with Survival in Stage III Colon Cancer Treated with Adjuvant Chemotherapy of Oxaliplatin and Infusional 5-Fluorouracil and Leucovorin (FOLFOX). Ann Surg Oncol. 2017;24:1289-1294 pubmed publisher
    ..as high MSI (MSI-H, ≥2 unstable markers), low MSI (MSI-L, 1 unstable marker), or microsatellite stable (MSS, no unstable marker). Of 598 patients, 8.4% showed MSI-H...
  43. Eimon P, Ghannad Rezaie M, De Rienzo G, Allalou A, Wu Y, Gao M, et al. Brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects. Nat Commun. 2018;9:219 pubmed publisher
    ..To determine whether drugs that enhance BAP complexity produces positive outcomes, we used light pulses to trigger seizures in a model of Dravet syndrome, an ..
  44. He Y, Penney M, Negandhi A, Parfrey P, Savas S, Yilmaz Y. XRCC3 Thr241Met and TYMS variable number tandem repeat polymorphisms are associated with time-to-metastasis in colorectal cancer. PLoS ONE. 2018;13:e0192316 pubmed publisher
    ..stage I-III colorectal cancer patients with microsatellite instability (MSI)-low (MSI-L) or microsatellite stable (MSS) tumors...
  45. Phipps A, Limburg P, Baron J, Burnett Hartman A, Weisenberger D, Laird P, et al. Association between molecular subtypes of colorectal cancer and patient survival. Gastroenterology. 2015;148:77-87.e2 pubmed publisher
    ..phenotype [CIMP] -positive, positive for BRAF mutation, negative for KRAS mutation); type 2 (microsatellite stable [MSS] or MSI-low, CIMP-positive, positive for BRAF mutation, negative for KRAS mutation); type 3 (MSS or MSI low, non-..
  46. Tajdaran K, Gordon T, Wood M, Shoichet M, Borschel G. A glial cell line-derived neurotrophic factor delivery system enhances nerve regeneration across acellular nerve allografts. Acta Biomater. 2016;29:62-70 pubmed publisher
    ..neurotrophic factor (GDNF) controlled release to implanted ANAs in rats using drug-loaded polymeric microspheres (MSs) embedded in a fibrin gel...
  47. Jiang X, Qiu L, Zhao H, Song Q, Zhou H, Han Q, et al. Transcriptomic responses of Perna viridis embryo to Benzo(a)pyrene exposure elucidated by RNA sequencing. Chemosphere. 2016;163:125-132 pubmed publisher
    The green mussel Perna viridis is an ideal biomonitor to evaluate marine environmental pollution. Benzo(a)pyrene (BaP) is a typical polycyclic aromatic hydrocarbon (PAH), which is well known for the mutagenic and carcinogenic ..
  48. Grote N, Katon W, Russo J, Lohr M, Curran M, Galvin E, et al. A Randomized Trial of Collaborative Care for Perinatal Depression in Socioeconomically Disadvantaged Women: The Impact of Comorbid Posttraumatic Stress Disorder. J Clin Psychiatry. 2016;77:1527-1537 pubmed publisher
    ..Interpersonal Psychotherapy and/or antidepressants, compared to intensive public health Maternity Support Services (MSS-Plus)...
  49. Liu Z, Li Q, Wu Q, Kuo D, Chen S, Hu X, et al. Removal Efficiency and Risk Assessment of Polycyclic Aromatic Hydrocarbons in a Typical Municipal Wastewater Treatment Facility in Guangzhou, China. Int J Environ Res Public Health. 2017;14: pubmed publisher
    ..The effluent BaP toxic equivalent quantities (TEQBaP) were above, or far above, standards in countries...
  50. Chiang H, Cho K, Zeng L, Chiang H. Characteristics of Carbon Material Formation on SBA-15 and Ni-SBA-15 Templates by Acetylene Decomposition and Their Bioactivity Effects. Materials (Basel). 2016;9: pubmed publisher
    ..High-ring PAHs (such as BaP (five rings); IND (six rings); DBA (five rings) and B[ghi]P (six rings)) exist in carbon materials...
  51. Gross G, Kwapil T, Raulin M, Silvia P, Barrantes Vidal N. The multidimensional schizotypy scale-brief: Scale development and psychometric properties. Psychiatry Res. 2018;261:7-13 pubmed publisher
    ..reports on the development and psychometric properties of a brief version of the Multidimensional Schizotypy Scale (MSS-B). The MSS-B contains 38 items that assess positive, negative, and disorganized schizotypy...
  52. Broderick N, Wade J, Meyer J, Hull M, Reeve R. Model invariance across genders of the Broad Autism Phenotype Questionnaire. J Autism Dev Disord. 2015;45:3133-47 pubmed publisher
    ..To facilitate genetic research, researchers employ the concept of the broad autism phenotype (BAP), a milder presentation of traits in undiagnosed relatives...
  53. Taglialegna A, Navarro S, Ventura S, Garnett J, Matthews S, Penadés J, et al. Staphylococcal Bap Proteins Build Amyloid Scaffold Biofilm Matrices in Response to Environmental Signals. PLoS Pathog. 2016;12:e1005711 pubmed publisher
    ..Here, we report that Bap protein of Staphylococcus aureus self-assembles into functional amyloid aggregates to build the biofilm matrix in ..
  54. Wilmes K, Schleimer J, Schreiber S. Spike-timing dependent inhibitory plasticity to learn a selective gating of backpropagating action potentials. Eur J Neurosci. 2017;45:1032-1043 pubmed publisher
    ..Inhibitory control of bAP spread, for example, can provide a switch for the plasticity of excitatory synapses...
  55. Hu T, Wang D, Yu Q, Li L, Mo X, Pan Z, et al. Aryl hydrocarbon receptor negatively regulates lipid synthesis and involves in cell differentiation of SZ95 sebocytes in vitro. Chem Biol Interact. 2016;258:52-8 pubmed publisher
    The aryl hydrocarbon receptor (AhR) is the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), benzo(a)pyrene (BaP) and other exogenous compounds...
  56. Huang C, Liao K, Chung F, Tseng H, Fang J, Lii S, et al. Different perceptions of narrative medicine between Western and Chinese medicine students. BMC Med Educ. 2017;17:85 pubmed publisher
    ..Exploratory factor analysis was undertaken. The response rate was 88.6% (412/465), including 270 (65.5%) MSs and 142 (34.5%) TCMSs, with a large reliability (Cronbach alpha = 0.934)...
  57. Wu W, Zou S, Lin L, Ji J, Zhang Y, Ma B, et al. Catalytic asymmetric Meerwein-Ponndorf-Verley reduction of glyoxylates induced by a chiral N,N'-dioxide/Y(OTf)3 complex. Chem Commun (Camb). 2017;53:3232-3235 pubmed publisher
    ..time accomplished via an N,N'-dioxide/Y(OTf)3 complex with aluminium alkoxide and molecular sieves (MSs) as crucial additives. A variety of optically active α-hydroxyesters were obtained with excellent results...
  58. Abohatem M, Bakil Y, Baaziz M. Plant Regeneration from Somatic Embryogenic Suspension Cultures of Date Palm. Methods Mol Biol. 2017;1637:203-214 pubmed publisher
    ..Low concentrations of 6-benzylaminopurine (BAP) to 0...
  59. Su X, Cai R, Uljarevic M. Predictors of Mental Health in Chinese Parents of Children with Autism Spectrum Disorder (ASD). J Autism Dev Disord. 2018;48:1159-1168 pubmed publisher
    ..the influence of parental intolerance of Uncertainty (IU), sensory sensitivity (SS) and Broader Autism Phenotype (BAP), as well as the severity of their children's autism symptoms and co-morbid symptoms, on the mental health of ..
  60. Xiao H, Yang Y, Zhang C, Liao E, Zhao H, Liao S. Karyotype analysis with amniotic fluid in 12365 pregnant women with indications for genetic amniocentesis and strategies of prenatal diagnosis. J Obstet Gynaecol. 2016;36:293-6 pubmed publisher
    ..23% in the women with abnormal maternal serum screening (MSS) tests...
  61. Salimena A, Lange C, Camussone C, Signorini M, Calvinho L, Brito M, et al. Genotypic and phenotypic detection of capsular polysaccharide and biofilm formation in Staphylococcus aureus isolated from bovine milk collected from Brazilian dairy farms. Vet Res Commun. 2016;40:97-106 pubmed
    ..The detection of the cap, icaAD, and bap genes was performed using PCR...
  62. Choi E, Kim M, Song S, Yoo N, Lee S. Intratumoral Heterogeneity of Frameshift Mutations in MECOM Gene is Frequent in Colorectal Cancers with High Microsatellite Instability. Pathol Oncol Res. 2017;23:145-149 pubmed publisher
    ..We analyzed the A7 of MECOM in 79 CRCs with high MSI (MSI-H) and 65 microsatellite stable/low MSI (MSS/MSI-L) CRCs by single-strand conformation polymorphism analysis and DNA sequencing...
  63. Luo Y, Kuo Y, Tsai M, Ho C, Tsai H, Hsu C, et al. Interleukin-24 as a target cytokine of environmental aryl hydrocarbon receptor agonist exposure in the lung. Toxicol Appl Pharmacol. 2017;324:1-11 pubmed publisher
    ..Knockdown AhR expression with short-hairpin RNA (shRNA) significantly reduced benzo[a]pyrene (BaP)-induced IL-24 mRNA levels...
  64. Rajpara R, Dudhagara D, Bhatt J, Gosai H, Dave B. Polycyclic aromatic hydrocarbons (PAHs) at the Gulf of Kutch, Gujarat, India: Occurrence, source apportionment, and toxicity of PAHs as an emerging issue. Mar Pollut Bull. 2017;119:231-238 pubmed publisher
    ..The toxic equivalent quotient for 6CPAHs ranged from 150.47 to 26,330ngg-1 BaPeq, encompassing 50.63% of ?PAH toxicity...
  65. Qin G, Wu M, Sang N. Sulfur dioxide and benzo(a)pyrene trigger apoptotic and anti-apoptotic signals at different post-exposure times in mouse liver. Chemosphere. 2015;139:318-25 pubmed publisher
    ..This study investigated the interaction effects between SO2 and BaP in mouse liver after long-term exposure...
  66. Nunes C, Guedes O, Alencar A, Peters O, Estrela C, Estrela C. Evaluation of Periapical Lesions and Their Association with Maxillary Sinus Abnormalities on Cone-beam Computed Tomographic Images. J Endod. 2016;42:42-6 pubmed publisher
    ..Apart from sex, no other patient information was available. The study sample was composed of CBCT images of 143 MSs of patients with at least 1 maxillary posterior tooth with a periapical lesion and 178 MSs of patients without ..
  67. Delsarte I, Danjou P, Veignie E, Rafin C. Synthesis of modified potato starches for aqueous solubilization of benzo[a]pyrene. Carbohydr Polym. 2016;144:83-8 pubmed publisher
    ..aqueous solubility and their ability to increase the solubility of a hydrophobic pollutant such as benzo[a]pyrene (BaP), used as a polycyclic aromatic hydrocarbon model...
  68. Chen W, Ding J, Jiang L, Liu Z, Zhou X, Shi D. DNA copy number profiling in microsatellite-stable and microsatellite-unstable hereditary non-polyposis colorectal cancers by targeted CNV array. Funct Integr Genomics. 2017;17:85-96 pubmed publisher
    ..criteria (AC) do not display evidence of mismatch repair defects, and the difference between microsatellite-stable (MSS) and microsatellite-unstable HNPCC remains poorly understood...
  69. Shephard E, Milosavljevic B, Pasco G, Jones E, Gliga T, Happe F, et al. Mid-childhood outcomes of infant siblings at familial high-risk of autism spectrum disorder. Autism Res. 2017;10:546-557 pubmed publisher
    ..Anxiety) compared to LR controls, but evidence for subclinical ASD symptoms (the broader autism phenotype, BAP) was limited in the group as a whole, although we identified a subgroup with elevated ASD traits...
  70. Mullin K, McDonald T, Wells R, Balmer B, Speakman T, Sinclair C, et al. Density, abundance, survival, and ranging patterns of common bottlenose dolphins (Tursiops truncatus) in Mississippi Sound following the Deepwater Horizon oil spill. PLoS ONE. 2017;12:e0186265 pubmed publisher
    ..were initiated on northern Gulf of Mexico common bottlenose dolphins (Tursiops truncatus) in Mississippi Sound (MSS) to determine density, abundance, and survival, during and after the oil spill, and to compare these results to ..
  71. Xie C, Pan Y, McLean C, Mar V, Wolfe R, Kelly J. Impact of scalp location on survival in head and neck melanoma: A retrospective cohort study. J Am Acad Dermatol. 2017;76:494-498.e2 pubmed publisher
    ..Melanoma-specific survival (MSS) was compared between scalp melanoma and other invasive CHNM...
  72. Bardbari A, Arabestani M, Karami M, Keramat F, Alikhani M, Bagheri K. Correlation between ability of biofilm formation with their responsible genes and MDR patterns in clinical and environmental Acinetobacter baumannii isolates. Microb Pathog. 2017;108:122-128 pubmed publisher
    ..related genes including BlaOXA-51, BlaOXA-23, BlaOXA-24, BlaOXA-58, bap, blaPER-1, and ompA were amplified by PCR. The rate of MDR A...
  73. Wassberg C, Lubberink M, Sorensen J, Johansson S. Repeatability of quantitative parameters of 18F-fluoride PET/CT and biochemical tumour and specific bone remodelling markers in prostate cancer bone metastases. EJNMMI Res. 2017;7:42 pubmed publisher
    ..bone turnover markers obtained at the time of each PET were PSA, ALP, S-osteocalcin, S-beta-CTx, 1CTP and BAP. A total of 47 index lesions and a range of 2-122 bone metastases per patient were evaluated...
  74. Song Q, Zhou H, Han Q, Diao X. Toxic responses of Perna viridis hepatopancreas exposed to DDT, benzo(a)pyrene and their mixture uncovered by iTRAQ-based proteomics and NMR-based metabolomics. Aquat Toxicol. 2017;192:48-57 pubmed publisher
    Dichlorodiphenyltrichloroethane (DDT) and benzo(a)pyrene (BaP) are environmental estrogens (EEs) that are ubiquitous in the marine environment...
  75. Wang W, Yu Q, Meng H, Han W, Li J, Zhang J. Catalytic liquefaction of municipal sewage sludge over transition metal catalysts in ethanol-water co-solvent. Bioresour Technol. 2018;249:361-367 pubmed publisher
    Catalytic liquefaction of (Municipal sewage sludge) MSS over transition metal catalysts in ethanol-water co-solvent (EWCS) was investigated...
  76. Tiwari V, Patel V, Tiwari M. In-silico screening and experimental validation reveal L-Adrenaline as anti-biofilm molecule against biofilm-associated protein (Bap) producing Acinetobacter baumannii. Int J Biol Macromol. 2018;107:1242-1252 pubmed publisher
    ..Biofilm-associated protein (Bap) plays a significant role in the biofilm formation by A...
  77. Kuźmicz K, Ciemniak A. Assessing contamination of smoked sprats (Sprattus sprattus) with polycyclic aromatic hydrocarbons (PAHs) and changes in its level during storage in various types of packaging. J Environ Sci Health B. 2017;:1-11 pubmed publisher
    ..99 µg kg-1 of benzo[a]pyrene (BaP) in fish skin...
  78. Perepechaeva M, Seredina T, Sidorova Y, Pivovarova E, Markel A, Lyakhovich V, et al. Quercetin Attenuates Benzo(?)pyrene-induced CYP1A Expression. Biomed Environ Sci. 2017;30:308-313 pubmed publisher
    ..an electrophoretic mobility shift assay) of proteins regulating CYP1A expression in untreated and benzo(?)pyrene (BaP)-treated rats. Wistar rats received quercetin, BaP, or both once daily for 1-3 days...
  79. Zhang M, Miao Y, Chen Q, Cai M, Dong W, Dai X, et al. BaP exposure causes oocyte meiotic arrest and fertilization failure to weaken female fertility. FASEB J. 2018;32:342-352 pubmed publisher
    Benzo[a]pyrene (BaP) is a ubiquitous environmental pollutant and carcinogen that is frequently found in particulate matter, with a diameter of ≤2.5 μm (PM2.5)...
  80. Dunnigan L, Morton B, van Eyk P, Ashman P, Zhang X, Hall P, et al. Polycyclic aromatic hydrocarbons on particulate matter emitted during the co-generation of bioenergy and biochar from rice husk. Bioresour Technol. 2017;244:1015-1023 pubmed publisher
    ..Significantly increased benzo(a)pyrene (BaP) - equivalent toxicity of the biochar and PM was observed at elevated pyrolysis temperatures.
  81. Borowski S, Boniecki P, Kubacki P, Czyzowska A. Food waste co-digestion with slaughterhouse waste and sewage sludge: Digestate conditioning and supernatant quality. Waste Manag. 2018;74:158-167 pubmed publisher
    In this study, the anaerobic mesophilic co-digestion of food waste (FW) with municipal sewage sludge (MSS) and slaughterhouse waste (SHW) was undertaken in 3-dm3 laboratory reactors as well as in 50-dm3 reactors ..
  82. Hayakawa K, Tang N, Nagato E, Toriba A, Sakai S, Kano F, et al. Long term trends in atmospheric concentrations of polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons: A study of Japanese cities from 1997 to 2014. Environ Pollut. 2018;233:474-482 pubmed publisher
    ..Nine polycyclic aromatic hydrocarbons (PAHs) with four to six rings, including pyrene (Pyr) and benzo[a]pyrene (BaP), were identified using high-performance liquid chromatography (HPLC) with fluorescence detection...
  83. Polom K, Das K, Marrelli D, Roviello G, Pascale V, Voglino C, et al. KRAS Mutation in Gastric Cancer and Prognostication Associated with Microsatellite Instability Status. Pathol Oncol Res. 2019;25:333-340 pubmed publisher
    ..3% of all cases. KRAS mutation was seen in 24 patients; 18 were MSI (75%) and 6 were microsatellite stable (MSS) (25%)...
  84. Zhang H, Wang R, Xue H, Hu R, Liu G. Characteristic and Source of Atmospheric PM10- and PM2.5-bound PAHs in a Typical Metallurgic City Near Yangtze River in China. Bull Environ Contam Toxicol. 2018;100:303-309 pubmed publisher
    ..The total BaP equivalent concentration (BAP-TEQ) was found to be maximum at DGS site in winter, whereas it was minimum at BGC ..
  85. Shiba K, Takei T, Yoshikawa G, Ogawa M. Deposition of a titania layer on spherical porous silica particles and their nanostructure-induced vapor sensing properties. Nanoscale. 2017;9:16791-16799 pubmed publisher
    ..induced the formation of a yolk-shell structure, which played a role in the sensitive/selective sensing properties for acetic acid when the yolk-shell particles were coated onto a nanomechanical Membrane-type Surface stress Sensor (MSS).
  86. Gauthami S, Kumar D, SivaSai K, Hegde N. The use of BirA-BAP system to study the effect of US2 and US11 on MHC class I heavy chain in cells. Immunol Lett. 2017;190:233-239 pubmed publisher
    ..human leukocyte antigen (HLA)-A2 (A2) heavy chain (HC), which was engineered to contain a biotin acceptor peptide (BAP)...
  87. RUBENSTEIN E, Edmondson Pretzel R, Windham G, Schieve L, Wiggins L, DiGuiseppi C, et al. The Broader Autism Phenotype in Mothers is Associated with Increased Discordance Between Maternal-Reported and Clinician-Observed Instruments that Measure Child Autism Spectrum Disorder. J Autism Dev Disord. 2017;47:3253-3266 pubmed publisher
    ..Sometimes, results between these instruments disagree. The broader autism phenotype (BAP) in parent-reporters may be associated with discordance...
  88. Mirzad A, Tada T, Ano H, Kobayashi I, Yamauchi T, Katamoto H. Seasonal changes in serum oxidative stress biomarkers in dairy and beef cows in a daytime grazing system. J Vet Med Sci. 2017;: pubmed publisher
    ..001) levels than those in JB cows during the study period. Serum levels of biological antioxidant potential (BAP) in both breeds were maintained at almost the same values during study period...
  89. Björklund K, Bondelind M, Karlsson A, Karlsson D, Sokolova E. Hydrodynamic modelling of the influence of stormwater and combined sewer overflows on receiving water quality: Benzo(a)pyrene and copper risks to recreational water. J Environ Manage. 2018;207:32-42 pubmed publisher
    ..Transport of copper (Cu) and benzo[a]pyrene (BaP) in the Göta River (Sweden) was simulated using a hydrodynamic model...
  90. Li C, Wang J, Su Q, Yang K, Chen C, Jiang X, et al. Postnatal Subacute Benzo(a)Pyrene Exposure Caused Neurobehavioral Impairment and Metabolomic Changes of Cerebellum in the Early Adulthood Period of Sprague-Dawley Rats. Neurotox Res. 2018;33:812-823 pubmed publisher
    Benzo(a)pyrene (BaP) is a widespread environmental contaminant that has been associated with neurotoxicity in mammals. It has strong toxic effects on the developing central nervous system...
  91. Cheng S, Lam W, Lee A, Fung K, Wu R, Fong W. Low-level doxorubicin resistance in benzo[a]pyrene-treated KB-3-1 cells is associated with increased LRP expression and altered subcellular drug distribution. Toxicol Appl Pharmacol. 2000;164:134-42 pubmed
    ..The P-glycoprotein (P-gp)-negative epidermoid pharyngeal carcinoma cells KB-3-1 were grown in 0.25 mM benzo[a]pyrene (BaP) for 3 months and increased resistance to doxorubicin, but not to vinblastine, colchicine, or cisplatin, was found...
  92. Kollipara L, Buchkremer S, Coraspe J, Hathazi D, Senderek J, Weis J, et al. In-depth phenotyping of lymphoblastoid cells suggests selective cellular vulnerability in Marinesco-Sjögren syndrome. Oncotarget. 2017;8:68493-68516 pubmed publisher
    b>SIL1 is a ubiquitous protein of the Endoplasmic Reticulum (ER) acting as a co-chaperone for the ER-resident chaperone, BiP...