SIK1

Summary

Gene Symbol: SIK1
Description: salt-inducible kinase 1
Alias: MSK, SIK, SNF1LK, SIK-1, SNF1-like kinase, myocardial SNF1-like kinase, salt-inducible protein kinase 1, serine/threonine protein kinase, serine/threonine-protein kinase SIK1, serine/threonine-protein kinase SNF1-like kinase 1, serine/threonine-protein kinase SNF1LK
Species: human

Top Publications

  1. pmc LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    Jose M Lizcano
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 23:833-43. 2004
  2. doi Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity
    Yoshiko Katoh Hashimoto
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Osaka 567 0085, Japan
    J Cell Biochem 104:1724-39. 2008
  3. ncbi TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain
    Hiroshi Takemori
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
    FEBS J 274:3202-9. 2007
  4. pmc LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription
    Hei Man Vincent Tang
    Department of Biochemistry, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
    Retrovirology 10:40. 2013
  5. pmc The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation
    Mahaboobi Jaleel
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 394:545-55. 2006
  6. ncbi Identification of novel protein kinases expressed in the myocardium of the developing mouse heart
    J C Ruiz
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138
    Mech Dev 48:153-64. 1994
  7. ncbi 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK
    Abdallah K Al-Hakim
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 118:5661-73. 2005
  8. pmc Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways
    K T Tamai
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0606
    Mol Cell Biol 14:8155-65. 1994
  9. ncbi Physical association and functional relationship between protein kinase C zeta and the actin cytoskeleton
    J Gomez
    Centro de Investigaciones Biologicas, Madrid, Spain
    Eur J Immunol 25:2673-8. 1995
  10. ncbi Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death
    D A Cross
    Neurology Centre of Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals, Harlow, Essex, UK
    J Neurochem 77:94-102. 2001

Detail Information

Publications141 found, 100 shown here

  1. pmc LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    Jose M Lizcano
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 23:833-43. 2004
    ..A total of 12 human kinases (NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK) are related to AMPK...
  2. doi Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity
    Yoshiko Katoh Hashimoto
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Osaka 567 0085, Japan
    J Cell Biochem 104:1724-39. 2008
    ..Salt inducible kinase 1 (SIK1) is a regulator in the feedback cascades of cAMP-mediated gene expression, while its kinase domain also features ..
  3. ncbi TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain
    Hiroshi Takemori
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
    FEBS J 274:3202-9. 2007
    ..In this review, we focus on the basic leucine zipper domain in the regulation of transcriptional activity of CREB and describe the functions of TORC and salt inducible kinase...
  4. pmc LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription
    Hei Man Vincent Tang
    Department of Biochemistry, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
    Retrovirology 10:40. 2013
    ..Treatment options are limited and prophylactic agents are not available. We have previously demonstrated an essential role for CREB-regulating transcriptional coactivators (CRTCs) in HTLV-1 transcription...
  5. pmc The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation
    Mahaboobi Jaleel
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 394:545-55. 2006
    ..Ten of the 14 AMPK-related protein kinases activated by LKB1, including SIK (salt-induced kinase), MARK (microtubule-affinity-regulating kinase) and BRSK (brain-specific kinase) isoforms, ..
  6. ncbi Identification of novel protein kinases expressed in the myocardium of the developing mouse heart
    J C Ruiz
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138
    Mech Dev 48:153-64. 1994
    ..we describe the characterization of two of the genes corresponding to the novel PCR products (designated Hek2 and msk)...
  7. ncbi 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK
    Abdallah K Al-Hakim
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 118:5661-73. 2005
    ..Interestingly, the 14-3-3 isoforms bound directly to the T-loop Thr residue of QSK and SIK, after these were phosphorylated by LKB1...
  8. pmc Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways
    K T Tamai
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0606
    Mol Cell Biol 14:8155-65. 1994
    ..cerevisiae HSF responds to multiple, distinct stimuli to activate yeast metallothionein gene transcription and that these stimuli elicit responses through nonidentical, genetically separable signalling pathways...
  9. ncbi Physical association and functional relationship between protein kinase C zeta and the actin cytoskeleton
    J Gomez
    Centro de Investigaciones Biologicas, Madrid, Spain
    Eur J Immunol 25:2673-8. 1995
    ..On the contrary, zeta PKC is not involved in the actin cytoskeleton organization when cells are maintained in IL-4, confirming our previous results showing that IL-4-induced signal transduction is PKC independent...
  10. ncbi Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death
    D A Cross
    Neurology Centre of Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals, Harlow, Essex, UK
    J Neurochem 77:94-102. 2001
    ....
  11. ncbi [Cardiac, respiratory and sleep disorders in patients with myotonic dystrophy]
    Marta Banach
    Pracownia EMG, Zakładu Neurofizjologii Klinicznej, Instytutu Psychiatrii i Neurologii w Warszawie
    Przegl Lek 66:1065-8. 2009
    ..This paper is aimed at characterizing some common cardiologic and sleep related respiratory disorders of patients with myotonic dystrophy which if not recognized in good time may lead to sudden death...
  12. pmc Glycogen synthase kinase-3beta (GSK3beta) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice
    Ping Zhang
    Department of Pediatric Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294, United States
    Mol Immunol 46:677-87. 2009
    ..tularensis LVS infection, and suggest that inhibition of GSK3beta may represent a novel therapeutic approach in the treatment of tularemia...
  13. ncbi Close association of herpes zoster reactivation and systemic lupus erythematosus (SLE) diagnosis: case-control study of patients with SLE or noninflammatory nusculoskeletal disorders
    Janet E Pope
    Division of Rheumatology, Department of Medicine, The University of Western Ontario, London, Ontario, Canada
    J Rheumatol 31:274-9. 2004
    ....
  14. doi The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases
    Celine Forzani
    Max Perutz Laboratories, Vienna, Austria
    FEBS J 278:1126-36. 2011
    ..In addition, PTI1-4 and MPK6 were found in vivo in the same protein complex. These results demonstrate that PTI1-4 signals via OXI1 and MPK6 signalling cascades...
  15. ncbi Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities
    J H Stack
    Division of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego School of Medicine, La Jolla 92093 0668
    J Biol Chem 269:31552-62. 1994
    ..On the basis of the role for Vps34p in vacuolar protein sorting, we propose that the production of a specific phosphoinositide, PtdIns(3)P, is involved in regulating intracellular protein sorting reactions in eukaryotic cells...
  16. ncbi Bub1 is activated by the protein kinase p90(Rsk) during Xenopus oocyte maturation
    M S Schwab
    Howard Hughes Medical Institute and Department of Pharmacology, University of Colorado, School of Medicine, 4200 East Ninth Ave, Denver, CO 80262, USA
    Curr Biol 11:141-50. 2001
    ..However, it is not known whether CSF-dependent metaphase arrest caused by p90(Rsk) involves components of the spindle assembly checkpoint...
  17. ncbi Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
    M P Coghlan
    Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Essex, UK
    Chem Biol 7:793-803. 2000
    ..This report describes the identification and characterisation of potent and selective small molecule inhibitors of GSK-3...
  18. ncbi Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse
    Salvatore Cuzzocrea
    Institute of Pharmacology, School of Medicine, University of Messina, Torre Biologica Policlinico Universitario, Via C Valeria Gazzi 98100 Messina, Italy
    Clin Immunol 120:57-67. 2006
    ..These data demonstrate that GSK-3beta inhibition exerts an anti-inflammatory effect during chronic inflammation and is able to ameliorate the tissue damage associated with CIA...
  19. pmc Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
    M Delcommenne
    British Columbia Cancer Agency, Jack Bell Research Centre, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6 Canada
    Proc Natl Acad Sci U S A 95:11211-6. 1998
    ..ILK is thus a receptor-proximal effector for the Pi(3)K-dependent, extracellular matrix and growth factor mediated, activation of PKB/AKT, and inhibition of GSK-3...
  20. pmc Phosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcription
    Liliana Endo-Munoz
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Virol J 2:17. 2005
    ..Our results showed faster, greater and stronger binding of Tat to TAR RNA after phosphorylation by PKR...
  21. ncbi The Marek's disease virus (MDV) unique short region: alphaherpesvirus-homologous, fowlpox virus-homologous, and MDV-specific genes
    P Brunovskis
    Department of Microbiology, Michigan State University, East Lansing 48824 1101
    Virology 206:324-38. 1995
    ..Thus, our sequence provides a foundation for further MDV studies aimed at resolving the apparent discrepancy between MDV's genetic and biologic properties...
  22. ncbi The barley serine/threonine kinase gene Rpg1 providing resistance to stem rust belongs to a gene family with five other members encoding kinase domains
    R Brueggeman
    Department of Crop and Soil Sciences, Washington State University, Pullman, WA 99164 6420, USA
    Theor Appl Genet 113:1147-58. 2006
    ..The genetic mapping, gene structures, and analysis of amino-acid sequences of the Rpg1 gene family members are presented...
  23. ncbi A novel transmembrane serine/threonine protein kinase gene from a rifamycin SV-producing amycolatopsis mediterranei U32
    W Zhang
    Department of Microbiology, Shanghai Institute of Plant Physiology, Academia Sinica, Shanghai, P R China
    Eur J Biochem 267:3744-52. 2000
    ..Although its biological role is still unknown, Amk protein kinase is the first transmembrane serine/threonine protein kinase described for genus Amycolatopsis...
  24. ncbi Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile vascular smooth muscle cells
    P Komalavilas
    Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    J Biol Chem 274:34301-9. 1999
    ..Increased activation of these MAP kinase pathways may be one mechanism by which cGMP and PKG activation mediate c-fos induction and increased proliferation of contractile adult RASMC...
  25. ncbi Characterization of PDK2 activity against protein kinase B gamma
    Conrad P Hodgkinson
    Division of Biochemistry and Molecular Biology, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, United Kingdom
    Biochemistry 41:10351-9. 2002
    ....
  26. doi Immunoprofile of mesenchymal chondrosarcoma: aberrant desmin and EMA expression, retention of INI1, and negative estrogen receptor in 22 female-predominant central nervous system and musculoskeletal cases
    Julie C Fanburg-Smith
    Department of Orthopaedic and Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Ann Diagn Pathol 14:8-14. 2010
    ..including atypical teratoid tumor in the central nervous system (CNS) and rhabdomyosarcoma in the musculoskeletal (MSK) locations. We reviewed the morphology of CNS and MSK cases and applied a panel of immunostains...
  27. ncbi Glycogen synthase kinase 3beta inhibition reduces the development of nonseptic shock induced by zymosan in mice
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    Shock 27:97-107. 2007
    ..This study provides the first evidence that TDZD-8 attenuates the degree of zymosan-induced, nonseptic shock in mice...
  28. ncbi Glycogen synthase kinase-3 regulation of chromatin segregation and cytokinesis in mouse preimplantation embryos
    Nicole Acevedo
    Department of Molecular, University of Michigan, Ann Arbor, Michigan, USA
    Mol Reprod Dev 74:178-88. 2007
    ..Inhibition of GSK-3 also resulted in abnormal chromatin segregation, evidenced by incomplete karyokinesis and micronuclei formation. These results suggest that GSK-3 activity is critical for early preimplantation embryonic development...
  29. ncbi Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases
    S Sturany
    Abteilung Innere Medizin I and Institut für Humangenetik, Medizinische Fakultät der Universität, Ulm, Germany
    J Biol Chem 276:3310-8. 2001
    We have isolated the full-length cDNA of a novel human serine threonine protein kinase gene...
  30. ncbi Ischemic preconditioning involves dual cardio-protective axes with p38MAPK as upstream target
    Norbert Nagy
    FAHA Cardiovascular Research Center, University of Connecticut School of Medicine Farmington, Cardiovascular Research Institute, CT 06030 1110, USA
    J Mol Cell Cardiol 42:981-90. 2007
    ..Since CREB is a downstream target of MSK-1 (mitogen- and stress-activated protein kinase-1) situated at the crossroad of ERK (extracellular receptor kinase) ..
  31. ncbi The HIV Dementia Scale: predictive power in mild dementia and HAART
    Kara Anne Bottiggi
    Graduate Center for Gerontology, College of Public Health, University of Kentucky, KY, USA
    J Neurol Sci 260:11-5. 2007
    ..With the advent of highly active antiretroviral therapy (HAART), the use of sensitive and efficient screening tests for HIV-D continue to be needed for identifying individuals who develop this disorder...
  32. ncbi On the physiological role of casein kinase II in Saccharomyces cerevisiae
    C V Glover
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens 30602, USA
    Prog Nucleic Acid Res Mol Biol 59:95-133. 1998
    ....
  33. pmc Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366
    Gopal P Sapkota
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U K
    Biochem J 368:507-16. 2002
    ..These observations provide the first link between ATM and LKB1 and suggest that ATM could regulate LKB1...
  34. ncbi Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation
    K A Martin
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:7892-8. 2001
    ..These data suggest a mechanism by which weak PI3-K agonists can regulate S6 phosphorylation and selective translation in the presence of mitogen-activated protein kinase signaling...
  35. ncbi Naproxen versus acetaminophen for therapy of soft tissue injuries to the ankle in children
    Victoria A Cukiernik
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Ann Pharmacother 41:1368-74. 2007
    Musculoskeletal (MSK) ankle injuries cause significant morbidity in ambulatory pediatric populations. No optimal pharmacotherapy is available.
  36. ncbi Integrin-linked kinase (ILK): a "hot" therapeutic target
    T N Yoganathan
    Kinetek Pharmaceuticals Inc, Vancouver, BC V6P6P2, Canada
    Biochem Pharmacol 60:1115-9. 2000
    ..A small molecule ILK inhibitor suppresses the phosphorylation of PKB at the Ser-473 but not the Thr-308 site in the PTEN mutant cells. These results indicate that inhibition of ILK may be of significant value in solid tumor therapy...
  37. pmc Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum
    M K Webster
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Mol Cell Biol 13:2031-40. 1993
    ....
  38. ncbi Contributory metabolic factors in the development of nephrolithiasis in patients with medullary sponge kidney
    T Yagisawa
    Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
    Am J Kidney Dis 37:1140-3. 2001
    Whether specific metabolic abnormalities are related to nephrolithiasis in patients with medullary sponge kidney (MSK) remains a debated issue...
  39. ncbi Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm
    Yoshiko Katoh
    Department of Biochemistry and Molecular Biology, Graduate School of Medicine H 1, Osaka University, Japan
    Eur J Biochem 271:4307-19. 2004
    Salt-inducible kinase-1 (SIK1) is phosphorylated at Ser577 by protein kinase A in adrenocorticotropic hormone-stimulated Y1 cells, and the phospho-SIK1 translocates from the nucleus to the cytoplasm...
  40. pmc Upregulation of casein kinase 1epsilon in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain
    Eri Sakurai
    Department of Pharmacology and Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Mol Pain 5:74. 2009
    ..In mammals, the CK1 family consists of seven members (alpha, beta, gamma1, gamma2, gamma3, delta, and epsilon) with a highly conserved kinase domain and divergent amino- and carboxy-termini...
  41. doi The pneumococcal eukaryotic-type serine/threonine protein kinase StkP co-localizes with the cell division apparatus and interacts with FtsZ in vitro
    Carmen Giefing
    Intercell AG, Vienna Biocenter 3, A 1030 Vienna, Austria
    Microbiology 156:1697-707. 2010
    ..Based on its cell-division-dependent localization and interaction with FtsZ, we propose that StkP plays a currently undefined role in cell division of pneumococcus...
  42. ncbi Medullary sponge kidney (Lenarduzzi-Cacchi-Ricci disease): a Padua Medical School discovery in the 1930s
    G Gambaro
    Division of Nephrology, Department of Biomedical and Surgical Sciences, University Hospital of Verona, Verona, Italy
    Kidney Int 69:663-70. 2006
    ..clinical diagnostics in the 1930s enabled the discovery of several diseases, including the medullary sponge kidney (MSK)...
  43. doi The sole serine/threonine protein kinase and its cognate phosphatase from Aquifex aeolicus targets pyrimidine biosynthesis
    Cristina Purcarea
    Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, 540 E Canfield Street, Detroit, MI 48201, USA
    Mol Cell Biochem 311:199-213. 2008
    ..The Thr/Ser kinase, its cognate phosphatase and a protein substrate may be elements of a simple signaling pathway, perhaps the most primitive example of this mode of regulation described thus far...
  44. ncbi Induction of cortical cataracts in cultured mouse lenses with H-89, an inhibitor of protein kinase A
    Harold I Calvin
    Department of Biochemistry, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA
    Curr Eye Res 27:269-78. 2003
    ..To compare the effects of two serine-threonine protein kinase inhibitors in a mouse lens culture system previously designed to investigate cortical cataracts caused by L-buthionine sulfoximine (BSO), inhibitor of GSH biosynthesis...
  45. pmc Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylation
    Rodrigo Jacamo
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 283:12877-87. 2008
    ..The present studies identify a novel mechanism induced by GPCR activation that leads to late, PKC-independent PKD activation...
  46. doi [Validity and reliability of a screening instrument for the identification of extensive work-related problems in patients with chronic diseases (SIMBO-C)]
    M Streibelt
    Charite Universitatsmedizin Berlin
    Rehabilitation (Stuttg) 48:135-44. 2009
    ..Adequate screening instruments do exist, but publications regarding their psychometric quality across indications are still missing...
  47. doi Salt-inducible kinase 1 in the rat pinealocyte: adrenergic regulation and role in arylalkylamine N-acetyltransferase gene transcription
    R Kanyo
    Department of Physiology, University of Alberta, Edmonton, Alberta, Canada
    Endocrinology 150:4221-30. 2009
    ..Here we report Sik1 expression was induced by norepinephrine (NE) in rat pinealocytes primarily through activation of beta-adrenergic ..
  48. ncbi [Effect of gonadotropin-releasing hormone-I agonist and gonadotropin-releasing hormone-II on endometrial carcinoma cell lines with different states of PTEN]
    Li jun Zhao
    Department of Gynecology, Peking University People s Hospital, Beijing 100044, China
    Zhonghua Fu Chan Ke Za Zhi 44:45-9. 2009
    ..To study the effect of gonadotropin-releasing hormone-I (GnRH-I) agonist triptorelin and gonadotropin-releasing hormone-II (GnRH-II) on human endometrial carcinoma with different states of PTEN...
  49. ncbi Is chronic widespread pain a predictor of all-cause morbidity? A 3 year prospective population based study in family practice
    Umesh T Kadam
    Primary Care Sciences Research Centre, Keele University, Staffordshire, United Kingdom
    J Rheumatol 32:1341-8. 2005
    ..To investigate whether chronic widespread pain predicts illness seen in general practice in a 3 year followup period...
  50. ncbi Musculoskeletal education in physical medicine and rehabilitation residency programs: graduating resident perspective
    Brian J Krabak
    Department of Physical Medicine and Rehabilitation, Johns Hopkins Sports Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Am J Phys Med Rehabil 86:493-8. 2007
    ..physical medicine and rehabilitation (PM&R) residents physicians' perceptions of their current musculoskeletal (MSK) training, to identify barriers perceived by resident physicians to improving MSK education experiences, and to ..
  51. ncbi A review of the natural progression of medullary sponge kidney and a novel grading system based on intravenous urography findings
    J A Forster
    Department of Urology, Pinderfields General Hospital, Mid Yorkshire Hospitals NHS Trust, Wakefield, UK
    Urol Int 78:264-9. 2007
    Medullary sponge kidney (MSK) is a developmental abnormality of the medullary pyramids of the kidney, characterised by cystic dilatations of the collecting ducts...
  52. doi Is there an urban-rural divide? Population surveys of rheumatic musculoskeletal disorders in the Pune region of India using the COPCORD Bhigwan model
    Vaijayanti Lagu Joshi
    Center for Rheumatic Diseases, CAMP, Pune, 411 001, India
    J Rheumatol 36:614-22. 2009
    To estimate urban prevalence of rheumatic musculoskeletal (MSK) disorders and compare to an earlier rural regional study.
  53. ncbi Bidirectional transcriptional activity of PGK-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice
    P C Scacheri
    National Human Genome Research Institute, National Institute of Health, Bethesda, Maryland 20892, USA
    Genesis 30:259-63. 2001
    ..exons 2-4 were replaced by a PGK-neomycin cassette inserted in the opposite direction of Men1 transcription (Men1(MSK/+)). Unexpectedly, the Men1 conventional knockout was lethal in heterozygous, chimeric animals...
  54. doi Palmitate affects insulin receptor phosphorylation and intracellular insulin signal in a pancreatic alpha-cell line
    Salvatore Piro
    Department of Internal Medicine, University of Catania, Catania 95122, Italy
    Endocrinology 151:4197-206. 2010
    ..Our data support the hypothesis that the chronic elevation of fatty acids contribute to alpha-cell dysregulation frequently observed in type 2 diabetes...
  55. ncbi The physical association of casein kinase 2 with nucleolin
    D Li
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 271:15662-8. 1996
    ..At present, the physiological significance of the strong interaction between CK2 and nucleolin, an excellent substrate for the enzyme, is not clear. However, this association may be important for regulating rDNA transcription...
  56. ncbi Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas
    Esther Conde
    Lung Cancer Group, Pathology Programme, Spanish National Cancer Centre CNIO, 28029 Madrid, Spain
    Hum Pathol 38:1351-60. 2007
    ....
  57. ncbi Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in beta-amyloid peptide neurotoxicity
    Ka Chun Suen
    Laboratory of Neurodegenerative Diseases, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong
    J Biol Chem 278:49819-27. 2003
    ..Elucidation of the upstream pathways for PKR activation can help us to understand how this kinase participates in Abeta peptide neurotoxicity and to develop effective neuroprotective strategy...
  58. ncbi Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders
    B Viollet
    Departement Endocrinologie, Métabolisme et Cancer, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, and INSERM, U567, Paris, France
    Diabetes Metab 33:395-402. 2007
    ..Thus, the relationship between AMPK activation and beneficial metabolic effects provide the rationale for the development of new therapeutic strategies in metabolic disorders...
  59. ncbi Cloning and characterization of a novel serine/threonine protein kinase gene expressed predominantly in developing brain
    K Nara
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Eur J Biochem 268:2642-51. 2001
    ..Fluorescence in situ hybridization analysis was used to map sbk to mouse chromosome 7F1-F3 and rat chromosome 1q21. These data suggest a role for SBK in signal-transduction pathways related to the control of brain development...
  60. ncbi Downregulation of c-myc protein by siRNA-mediated silencing of DNA-PKcs in HeLa cells
    Jing An
    Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, Peoples Republic of China
    Int J Cancer 117:531-7. 2005
    ....
  61. pmc Discovery of potent, orally active compounds of tyrosine kinase and serine/threonine-protein kinase inhibitor with anti-tumor activity in preclinical assays
    Yun qing Qiu
    State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, School of Medicine, Zhejiang University, 310003, Hangzhou, China
    Afr J Tradit Complement Altern Med 9:431-9. 2012
    ..The IC₅₀ value of KDR of BB1-10 is less than sorafenib. especially against c-RAF, PDGFR, c-KIT, KDR compared to sorafenib. These compounds are potent Raf1 and Flt4 kinase inhibitors...
  62. ncbi Roles of several domains identified in the primary structure of salt-inducible kinase (SIK)
    Nanao Horike
    Department of Molecular Physiological Chemistry, Osaka University Medical School, 2 2 Yamadaoka, Suita, Osaka, 565 0871 Japan
    Endocr Res 28:291-4. 2002
    Salt-inducible kinase (SIK), a 776 amino acids-protein, contains a kinase domain in the NH2-terminal 278 amino acid residues, and the biological functions of its COOH-terminal half have yet to be clarified...
  63. pmc Three-dimensional reconstruction of the membrane skeleton at the plasma membrane interface by electron tomography
    Nobuhiro Morone
    Kusumi Membrane Organizer Project, Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Nagoya 460 0012, Japan
    J Cell Biol 174:851-62. 2006
    ..The membrane skeleton (MSK) primarily consists of actin filaments and associated proteins...
  64. pmc Monte Carlo study of the effects of system geometry and antiscatter grids on cone-beam CT scatter distributions
    A Sisniega
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Med Phys 40:051915. 2013
    ....
  65. pmc Calcium and calmodulin-dependent serine/threonine protein kinase type II (CaMKII)-mediated intramolecular opening of integrin cytoplasmic domain-associated protein-1 (ICAP-1α) negatively regulates β1 integrins
    Angelique Millon-Fremillon
    Institut Albert Bonniot U823, INSERM, F 38042 Grenoble, France
    J Biol Chem 288:20248-60. 2013
    ..Our results point to a molecular mechanism for the phosphorylation-dependent control of ICAP-1α function by CaMKII, allowing the dynamic control of β1 integrin activation and cell adhesion. ..
  66. doi Salt-inducible kinase 1 is involved in high glucose-induced mesangial cell proliferation mediated by the ALK5 signaling pathway
    Jie Yu
    Department of Traditional Chinese Medicine and Endocrinology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P R China
    Int J Mol Med 32:151-7. 2013
    ..Salt-inducible kinase 1 (SIK1) prevents fibrosis by downregulating ALK5, while the expression level of the SIK1 protein itself is downregulated ..
  67. pmc Exendin-4 as a stimulator of rat insulin I gene promoter activity via bZIP/CRE interactions sensitive to serine/threonine protein kinase inhibitor Ro 31-8220
    Oleg G Chepurny
    Department of Physiology, New York University School of Medicine, New York, New York 10016, USA
    Endocrinology 143:2303-13. 2002
    ..targets PKC as as well as the 90-kDa ribosomal S6 kinase (RSK) and mitogen- and stress-activated protein kinase (MSK) family of cAMP response element-binding protein (CREB) kinases, blocked the stimulatory action of Ex-4 at RIP1-Luc...
  68. doi Possible role of brain salt-inducible kinase 1 in responses to central sodium in Dahl rats
    Bing S Huang
    Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 303:R236-45. 2012
    ..Salt-inducible kinase 1 (SIK1) increases Na(+)/K(+)-ATPase activity in kidney cells...
  69. ncbi RNAi-induced K-Ras gene silencing suppresses growth of EC9706 cells and enhances chemotherapy sensitivity of esophageal cancer
    Xin Jie Wang
    Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
    Asian Pac J Cancer Prev 13:6517-21. 2012
    ..and chemotherapy sensitivity of EC9706 cells after K-Ras gene silencing, an expression carrier pSilencer-siK-Ras was constructed, and the EC9706 cell line was transfected using a liposome technique...
  70. doi Downregulation of the renal outer medullary K(+) channel ROMK by the AMP-activated protein kinase
    Balasaheb Siraskar
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Pflugers Arch 465:233-45. 2013
    ..In conclusion, AMPK downregulates ROMK, an effect compromising the ability of the kidney to excrete K(+) following an acute K(+) load...
  71. doi Improving musculoskeletal health: global issues
    Girish M Mody
    Department of Rheumatology, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Congella, Durban, South Africa
    Best Pract Res Clin Rheumatol 26:237-49. 2012
    Musculoskeletal (MSK) disorders are among the leading reasons why patients consult a family or primary health practitioner, take time off work and become disabled. Many of the MSK disorders are more common in the elderly...
  72. pmc The role of BRAF V600 mutation in melanoma
    Paolo A Ascierto
    Department of Melanoma, Istituto Nazionale Tumori Fondazione G, Pascale, Naples, Italy
    J Transl Med 10:85. 2012
    ....
  73. doi Novel mithramycins abrogate the involvement of protein factors in the transcription of cell cycle control genes
    Carolina Vizcaino
    Instituto de Biologia Molecular de Barcelona, CSIC, Parc Cientific de Barcelona, Barcelona, Spain
    Biochem Pharmacol 84:1133-42. 2012
    The effects of mithramycin SK (MSK) and demycarosyl-3D-β-D-digitoxosyl-mithramycin SK (DIG-MSK; EC-8042), two novel analogs of the antitumor antibiotic mithramycin A, on gene transcription were examined in human HCT116 colon carcinoma ..
  74. doi 3D-QSAR study of Chk1 kinase inhibitors based on docking
    Lingzhou Zhao
    Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, 100875, China
    J Mol Model 18:3669-94. 2012
    ..The results suggested that the developed models and the obtained CHk1 inhibitor binding structures might be reliable to predict the activity of new inhibitors and reasonable for the future drug design...
  75. doi Mammalian target of rapamycin (mTOR) inhibition reduces cerebral vasospasm following a subarachnoid hemorrhage injury in canines
    Weiguang Zhang
    Department of Anatomy, Shandong University School of Medicine, Shandong 250012, China
    Exp Neurol 233:799-806. 2012
    ....
  76. doi Mitogen-activated protein kinase p38 regulates Krox-20 to direct Schwann cell differentiation and peripheral myelination
    Shireen Hossain
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    Glia 60:1130-44. 2012
    ..of p38 were explored: MAPK-activated protein kinase-2 (MK2), mitogen and stress-activated protein kinase-1 (MSK-1), and the transcription factor cAMP response element-binding protein (CREB)...
  77. doi TAK-960, a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple dosing regimens
    Yuichi Hikichi
    Takeda Pharmaceutical Company Ltd, 26 1 Muraoka Higashi 2 Chome, Fujisawa, Kanagawa 251 8555, Japan
    Mol Cancer Ther 11:700-9. 2012
    ..TAK-960 has entered clinical evaluation in patients with advanced cancers...
  78. doi Cellular response and activation of apoptosis by mithramycin SK in p21(WAF1)-deficient HCT116 human colon carcinoma cells
    Marc Bataller
    Instituto de Biologia Molecular de Barcelona, CSIC, Parc Cientific de Barcelona, Barcelona, Spain
    Cancer Lett 292:80-90. 2010
    HCT116 (p21(-/-)) human colon carcinoma cells treated with mithramycin SK (MSK), a novel analog of the antitumor antibiotic mithramycin A (MTA), were transiently arrested in G2/M, with some cells entering a faulty mitotic cycle without ..
  79. pmc Bone disease in medullary sponge kidney and effect of potassium citrate treatment
    Antonia Fabris
    Division of Nephrology, Department of Biomedical and Surgical Sciences, University Hospital of Verona, Verona, Italy
    Clin J Am Soc Nephrol 4:1974-9. 2009
    In medullary sponge kidney (MSK)-a common malformative renal condition in patients with calcium nephrolithiasis-hypercalciuria, incomplete distal renal tubular acidosis, and hypocitraturia are common...
  80. pmc Emergency department discharge diagnosis and adverse health outcomes in older adults
    S Nicole Hastings
    Center for Health Services Research in Primary Care, Education and Clinical Center, Veterans Affairs Medical Center, Durham, North Carolina, USA
    J Am Geriatr Soc 57:1856-61. 2009
    ..To determine the relationship between the reason for an emergency department (ED) visit and subsequent risk of adverse health outcomes in older adults discharged from the ED...
  81. doi Emerging treatment combinations: integrating therapy into clinical practice
    Serena T Wong
    The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903 2681, USA
    Am J Health Syst Pharm 66:S9-S14. 2009
    ..To review data supporting the effectiveness of emerging treatment options for metastatic breast cancer...
  82. doi AKT (protein kinase B) is implicated in meiotic maturation of porcine oocytes
    Jaroslav Kalous
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Rumburska 89, 277 21 Libechov, Czech Republic
    Reproduction 138:645-54. 2009
    ..These results suggest that activity of AKT is not essential for induction of GVBD in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage...
  83. ncbi BRK/Sik expression in the gastrointestinal tract and in colon tumors
    X Llor
    Department of Molecular Genetics, University of Illinois College of Medicine, Chicago 60607, USA
    Clin Cancer Res 5:1767-77. 1999
    ..intestinal cDNA library that was screened with the cDNA encoding the mouse epithelial-specific tyrosine kinase Sik. Although BRK and Sik share only 80% amino acid sequence identity, Southern blot hybridizations confirmed that the ..
  84. pmc Switching catalysis from hydrolysis to perhydrolysis in Pseudomonas fluorescens esterase
    De Lu Tyler Yin
    Department of Biochemistry, Molecular Biology, and Biophysics and the Biotechnology Institute, University of Minnesota, 1479 Gortner Avenue, St Paul, Minnesota 55108, USA
    Biochemistry 49:1931-42. 2010
    ..we showed that a single amino acid substitution in the alcohol binding pocket, L29P, in Pseudomonas fluorescens (SIK WI) aryl esterase (PFE) increased the specificity constant of PFE for peracetic acid formation >100-fold [..
  85. ncbi DNA-PK, the DNA-activated protein kinase, is differentially expressed in normal and malignant human tissues
    U Moll
    Department of Pathology, State University of New York at Stony Brook, 11794, USA
    Oncogene 18:3114-26. 1999
    ..Our results suggest that the apparent absence of DNA-PKcs and Ku80 from some cells or tissues is a consequence of post-transcriptional mechanisms that regulate protein levels...
  86. doi Effects of fasudil, a Rho-kinase inhibitor, on contraction of pig bladder tissues with or without urothelium
    Katsuhisa Tatsumiya
    Department of Urology, Dokkyo Medical University, Mibu, Tochigi, Japan
    Int J Urol 16:959-66. 2009
    ..To investigate the effects of fasudil, a Rho-associated serine-threonine protein kinase inhibitor, on contraction of the pig urinary bladder tissues with or without urothelium...
  87. pmc Targeting of renal proximal tubule Na,K-ATPase by salt-inducible kinase
    Mary Taub
    Department of Biochemistry, University at Buffalo, 140 Farber Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Biochem Biophys Res Commun 393:339-44. 2010
    ..upon the Na,K-ATPase, which is controlled by a complex regulatory network, including Salt-Inducible Protein Kinase (SIK)...
  88. doi Cognitive impairment following prenatal immune challenge in mice correlates with prefrontal cortical AKT1 deficiency
    Byron K Y Bitanihirwe
    Laboratory of Behavioural Neurobiology, ETH Zurich, Switzerland
    Int J Neuropsychopharmacol 13:981-96. 2010
    ....
  89. doi Phylogenetic and functional features of the plastid transcription kinase cpCK2 from Arabidopsis signify a role of cysteinyl SH-groups in regulatory phosphorylation of plastid sigma factors
    Hacer Türkeri
    Laboratory of Plant Cell Physiology and Molecular Biology, University of Bochum, Universitaetsstr 150, Germany
    FEBS J 279:395-409. 2012
    ..For instance, while Cys4 but not Cys2 is essential for activity, the latter seems to be involved in the formation of intermolecular (regulatory) disulfide bonds...
  90. doi Characterization of the cellular action of the MSK inhibitor SB-747651A
    Shaista Naqvi
    MRC Protein Phosphorylation Unit, Sir James Black Complex, University of Dundee, Dundee DD1 5EH, Scotland, U K
    Biochem J 441:347-57. 2012
    ..In cells, SB-747651A fully inhibited MSK activity at 5-10 μM...
  91. ncbi The pro-survival function of Akt kinase can be overridden or altered to contribute to induction of apoptosis
    Doris Mangiaracina Benbrook
    Department of Gynecologic Oncology, University of Oklahoma Health Sciences Centre, Oklahoma City, Oklahoma, 73104, USA
    Curr Cancer Drug Targets 11:586-99. 2011
    ..Upstream, caveolin-1 stimulated the pro-apoptotic function. Implications of the opposing functions of Akt in cancer therapy are discussed...
  92. doi Utility and feasibility of musculoskeletal ultrasonography (MSK US) in rheumatology practice in Canada: needs assessment
    Maggie J Larche
    McMaster University and St Joseph s Healthcare, Suite 610, 25 Charlton Ave East, Hamilton, ON, L8N 1Y2, Canada
    Clin Rheumatol 30:1277-83. 2011
    The utility of musculoskeletal ultrasound (MSK US) is being extensively explored and evaluated amongst European rheumatologists. However, utilization of MSK US by rheumatologists in Canada is much less common...
  93. doi PI3 kinase regulation of skeletal muscle hypertrophy and atrophy
    David J Glass
    Novartis Institute for Biomedical Research, Cambridge, MA 02139, USA
    Curr Top Microbiol Immunol 346:267-78. 2010
    ..These findings show that myostatin signaling acts by blocking genes induced during differentiation, even in a myotube, as opposed to activating the distinct "atrophy program."..
  94. ncbi The histidine-221 to tyrosine substitution in v-mos abolishes its biological function and its protein kinase activity
    B Singh
    Department of Molecular Pathology, University of Texas System Cancer Center, M D Anderson Hospital and Tumor Institute, Houston 77030
    Virology 164:114-20. 1988
    ....
  95. pmc Specific nucleoporin requirement for Smad nuclear translocation
    Xiaochu Chen
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Mol Cell Biol 30:4022-34. 2010
    ..Here we identify a subset of nucleoporins that, in conjunction with Msk (Drosophila Imp7/8), specifically mediate activation-induced nuclear translocation of MAD (Drosophila Smad1) but ..
  96. doi Looking upstream to understand low back pain and return to work: psychosocial factors as the product of system issues
    Sophie Soklaridis
    University Health Network, Centre of Research Expertise in Improved Disability Outcomes, Toronto, Ontario, Canada M6J 3S3
    Soc Sci Med 71:1557-66. 2010
    Low back pain (LBP) is the most common and expensive musculoskeletal (MSK) disorder in industrialized countries...
  97. ncbi Identification and characterization of DBK, a novel putative serine/threonine protein kinase from human endothelial cells
    W Chu
    Department of Inflammation Autoimmune Diseases, Hoffmann La Roche Inc, Roche Research Center, Nutley NJ 07110 1199
    Eur J Biochem 225:695-702. 1994
    ..Using somatic cell hybrids, the DBK gene has been localized to human chromosome 14. The ubiquitous expression and high degree of conservation of DBK across species suggest that DBK may play an important role in cell functions...
  98. pmc Role of Streptococcus mutans eukaryotic-type serine/threonine protein kinase in interspecies interactions with Streptococcus sanguinis
    Lin Zhu
    College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Arch Oral Biol 55:385-90. 2010
    ..A potential target of H2O2 is the cell-envelop of S. mutans. In the present study, the role of cell-envelop associated eukaryotic serine/threonine protein kinase (STPK) in S. mutans during interspecies competition has been investigated...
  99. ncbi Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins
    Y Nishimura
    Department of Molecular and Cellular Pharmacology, Mie University School of Medicine, 2 174 Edobashi, Mie, Tsu, 514 8507, Japan
    Biochem Biophys Res Commun 254:21-6. 1999
    ..hVAP-B had VAMP-binding ability. Moreover, hVAP-A and hVAP-B associated with each other through their respective TMDs. These results suggest that complex formation by VAPs might be important in the trafficking of mammalian vesicle...
  100. ncbi Cerebrovascular changes in the basal ganglia with HIV dementia
    J R Berger
    Department of Neurology, University of Kentucky College of Medicine, Lexington 40536 2184, USA
    Neurology 54:921-6. 2000
    ..Many investigators have proposed a contribution of a disrupted blood-brain barrier (BBB) to the pathogenesis of HIV dementia...
  101. ncbi Salutary properties of YC-1 in the cardiovascular and hematological systems
    David Anthony Tulis
    Cardiovascular Disease Research Program, J L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, North Carolina 27707, USA
    Curr Med Chem Cardiovasc Hematol Agents 2:343-59. 2004
    ....

Research Grants74

  1. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2010
    ..We plan to characterize mechanisms of ET-1-stimulated sickle red cell dehydration as a means to develop ET-1 receptor antagonists as a novel therapy in the treatment of sickle cell disease. ..
  2. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2009
    ..We plan to characterize mechanisms of ET-1-stimulated sickle red cell dehydration as a means to develop ET-1 receptor antagonists as a novel therapy in the treatment of sickle cell disease. ..
  3. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2009
    ..We plan to characterize mechanisms of ET-1-stimulated sickle red cell dehydration as a means to develop ET-1 receptor antagonists as a novel therapy in the treatment of sickle cell disease. ..
  4. AMPK as a redox sensor and modulator
    Ming Hui Zou; Fiscal Year: 2009
    ..Completion of the proposed studies will provide novel insights into whether AMPK is a potential target for therapy in smoking and common diseases including aging, obesity, diabetes, hypertension, and atherosclerosis. ..
  5. AMPK as a redox sensor and modulator
    Ming Hui Zou; Fiscal Year: 2010
    ..Completion of the proposed studies will provide novel insights into whether AMPK is a potential target for therapy in smoking and common diseases including aging, obesity, diabetes, hypertension, and atherosclerosis. ..
  6. AKT Signaling and Oxidative Stress Regulation of Erythropoiesis
    Saghi Ghaffari; Fiscal Year: 2009
    ..Evidence from our laboratory suggests that AKT serine threonine protein kinase mediates significant functions in the regulation of erythroid cell division and maturation downstream ..
  7. AKT Signaling and Oxidative Stress Regulation of Erythropoiesis
    Saghi Ghaffari; Fiscal Year: 2010
    ..Evidence from our laboratory suggests that AKT serine threonine protein kinase mediates significant functions in the regulation of erythroid cell division and maturation downstream ..
  8. Mechanism of Metformin Action in Normal and PCOS Theca Cells
    Jan M McAllister; Fiscal Year: 2010
    ..We will examine the role(s) of LKB1, AMPK, and the salt inducible kinases, SIK1 and SIK2, in metformin inhibition of CYP17 and CYP11A1 gene expression and androgen biosynthesis in normal and PCOS ..
  9. Mechanism of Metformin Action in Normal and PCOS Theca Cells
    Jan M McAllister; Fiscal Year: 2010
    ..We will examine the role(s) of LKB1, AMPK, and the salt inducible kinases, SIK1 and SIK2, in metformin inhibition of CYP17 and CYP11A1 gene expression and androgen biosynthesis in normal and PCOS ..
  10. IP3 Receptor Phosphorylation by Akt Kinase
    Suresh Joseph; Fiscal Year: 2006
    ..The studies proposed in this application are significant since both signaling systems play important roles in many clinically relevant processes such as insulin and growth factor signaling, angiogenesis and oncogenesis. ..
  11. S6 PHOSPHORYLATION AND TYROSINE PROTEIN KINASES
    JAMES MALLER; Fiscal Year: 1993
    ....
  12. Control of Vascular Cell Motility by CaMKII
    Harold A Singer; Fiscal Year: 2010
    ....
  13. COMPLEMENTATION ASSAY TO SCREEN FOR KINASE INHIBITORS
    RICHARD EGLEN; Fiscal Year: 2004
    ..abstract_text> ..
  14. Regulation of Akt and glucose transport by prolactin
    Steven Anderson; Fiscal Year: 2006
    ..These studies should provide important information about other roles for prolactin in the mammary gland and identify the mechanisms by which prolactin regulates these diverse processes. ..
  15. E COLI TRANSLOCATION ACROSS INTESTINAL EPITHELIUM
    Michelle Pietzak; Fiscal Year: 2003
    ..Under the mentorship of Kwang Sik Kim M.D., Dr...
  16. THE ROLE OF THE AKT/PKB SIGNALING IN INSULIN ACTION
    Morris Birnbaum; Fiscal Year: 2004
    ..It is anticipated that, through these studies, a much deeper understanding will be obtained concerned the critical intracellular events which mediate insulin's regulation of essential metabolic functions. ..
  17. INTERACTIONS OF MYOTONIC DYSTROPHY PROTEIN KINASE
    Henry Epstein; Fiscal Year: 2000
    ....
  18. Development of Novel p38 MAPK Inhibitors as Therapeutics for CNS Disorders
    DANIEL MARTIN WATTERSON; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE Successful completion of the proposed investigations will provide novel, efficacious compounds required for clinical development of new therapies for neurological disorders. ..
  19. Exercise Regulation of Glucose Metabolism in Skeletal Muscle
    LAURIE GOODYEAR; Fiscal Year: 2009
    ..We will test the hypothesis that AMPK-related kinases SNARK ARK5, SIK1 and MARK4 regulate glucose uptake by using novel techniques including mutagenesis and in vivo gene transfer into ..
  20. Development of Novel p38 MAPK Inhibitors as Therapeutics for CNS Disorders
    D Watterson; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE Successful completion of the proposed investigations will provide novel, efficacious compounds required for clinical development of new therapies for neurological disorders. ..
  21. Exercise Regulation of Glucose Metabolism in Skeletal Muscle
    Laurie J Goodyear; Fiscal Year: 2010
    ..We will test the hypothesis that AMPK-related kinases SNARK ARK5, SIK1 and MARK4 regulate glucose uptake by using novel techniques including mutagenesis and in vivo gene transfer into ..
  22. Molecular mechanisms of lung disease in ataxia telangiectasia
    JoAnn M Sekiguchi; Fiscal Year: 2011
    ..Thus, the goals of this research proposal are to gain a better understanding of the causes of chronic lung disease in these patients and to identify effective therapeutic strategies to treat this fatal symptom. ..
  23. PKA-Hypothermia Bridge: A New Therapeutic Approach for Traumatic Brain Injury
    Larry W Jenkins; Fiscal Year: 2010
    ..The drug may also be useful in the rehabilitation period after brain injury has occurred. Currently, there is no known effective treatment that has been translated to clinical TBI care. ..
  24. Mechanism of Opiate Induced Audiovestibular Dysfunction
    Gail Ishiyama; Fiscal Year: 2006
    ....
  25. PKA-Hypothermia Bridge: A New Therapeutic Approach for Traumatic Brain Injury
    Larry Jenkins; Fiscal Year: 2009
    ..The drug may also be useful in the rehabilitation period after brain injury has occurred. Currently, there is no known effective treatment that has been translated to clinical TBI care. ..
  26. P34CDC2 AND CELL CYCLE CONTROL
    Helen Piwnica Worms; Fiscal Year: 2003
    ..Proteins involved in these pathways may on day be used as diagnostic markers or as targets for designing anti-proliferative drugs. ..
  27. THE ROLE OF THE AKT/PKB SIGNALING IN INSULIN ACTION
    MORRIS JAY BIRNBAUM; Fiscal Year: 2010
    ..It is the aim of these studies to understand why lipid metabolism is so disturbed in Type II Diabetes Mellitus and to identify novel targets to treat this aspect of the disease. ..
  28. GASTROINTESTINAL PEPTIDE SIGNALING THROUGH PKC/PKD
    JUAN ROZENGURT; Fiscal Year: 2002
    ....
  29. Modulation of CNS Proinflammatory Cytokine Production
    Linda J Van Eldik; Fiscal Year: 2010
    ....