Genomes and Genes
Gene Symbol: SIK1
Description: salt-inducible kinase 1
Alias: MSK, SIK, SNF1LK, SIK-1, SNF1-like kinase, myocardial SNF1-like kinase, salt-inducible protein kinase 1, serine/threonine protein kinase, serine/threonine-protein kinase SIK1, serine/threonine-protein kinase SNF1-like kinase 1, serine/threonine-protein kinase SNF1LK
Publications144 found, 100 shown here
- LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1Jose M Lizcano
MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
EMBO J 23:833-43. 2004..A total of 12 human kinases (NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK) are related to AMPK...
- Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activityYoshiko Katoh Hashimoto
Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Osaka 567 0085, Japan
J Cell Biochem 104:1724-39. 2008..Salt inducible kinase 1 (SIK1) is a regulator in the feedback cascades of cAMP-mediated gene expression, while its kinase domain also features ..
- TORC-SIK cascade regulates CREB activity through the basic leucine zipper domainHiroshi Takemori
Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
FEBS J 274:3202-9. 2007..In this review, we focus on the basic leucine zipper domain in the regulation of transcriptional activity of CREB and describe the functions of TORC and salt inducible kinase...
- LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcriptionHei Man Vincent Tang
Department of Biochemistry, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
Retrovirology 10:40. 2013..Treatment options are limited and prophylactic agents are not available. We have previously demonstrated an essential role for CREB-regulating transcriptional coactivators (CRTCs) in HTLV-1 transcription...
- The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activationMahaboobi Jaleel
MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
Biochem J 394:545-55. 2006..Ten of the 14 AMPK-related protein kinases activated by LKB1, including SIK (salt-induced kinase), MARK (microtubule-affinity-regulating kinase) and BRSK (brain-specific kinase) isoforms, ..
- Identification of novel protein kinases expressed in the myocardium of the developing mouse heartJ C Ruiz
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138
Mech Dev 48:153-64. 1994..we describe the characterization of two of the genes corresponding to the novel PCR products (designated Hek2 and msk)...
- 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIKAbdallah K Al-Hakim
MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
J Cell Sci 118:5661-73. 2005..Interestingly, the 14-3-3 isoforms bound directly to the T-loop Thr residue of QSK and SIK, after these were phosphorylated by LKB1...
- Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathwaysK T Tamai
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0606
Mol Cell Biol 14:8155-65. 1994..cerevisiae HSF responds to multiple, distinct stimuli to activate yeast metallothionein gene transcription and that these stimuli elicit responses through nonidentical, genetically separable signalling pathways...
- Physical association and functional relationship between protein kinase C zeta and the actin cytoskeletonJ Gomez
Centro de Investigaciones Biologicas, Madrid, Spain
Eur J Immunol 25:2673-8. 1995..On the contrary, zeta PKC is not involved in the actin cytoskeleton organization when cells are maintained in IL-4, confirming our previous results showing that IL-4-induced signal transduction is PKC independent...
- Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from deathD A Cross
Neurology Centre of Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals, Harlow, Essex, UK
J Neurochem 77:94-102. 2001....
- [Cardiac, respiratory and sleep disorders in patients with myotonic dystrophy]Marta Banach
Pracownia EMG, Zakładu Neurofizjologii Klinicznej, Instytutu Psychiatrii i Neurologii w Warszawie
Przegl Lek 66:1065-8. 2009..This paper is aimed at characterizing some common cardiologic and sleep related respiratory disorders of patients with myotonic dystrophy which if not recognized in good time may lead to sudden death...
- Glycogen synthase kinase-3beta (GSK3beta) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in micePing Zhang
Department of Pediatric Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294, United States
Mol Immunol 46:677-87. 2009..tularensis LVS infection, and suggest that inhibition of GSK3beta may represent a novel therapeutic approach in the treatment of tularemia...
- Close association of herpes zoster reactivation and systemic lupus erythematosus (SLE) diagnosis: case-control study of patients with SLE or noninflammatory nusculoskeletal disordersJanet E Pope
Division of Rheumatology, Department of Medicine, The University of Western Ontario, London, Ontario, Canada
J Rheumatol 31:274-9. 2004....
- The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinasesCeline Forzani
Max Perutz Laboratories, Vienna, Austria
FEBS J 278:1126-36. 2011..In addition, PTI1-4 and MPK6 were found in vivo in the same protein complex. These results demonstrate that PTI1-4 signals via OXI1 and MPK6 signalling cascades...
- Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activitiesJ H Stack
Division of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego School of Medicine, La Jolla 92093 0668
J Biol Chem 269:31552-62. 1994..On the basis of the role for Vps34p in vacuolar protein sorting, we propose that the production of a specific phosphoinositide, PtdIns(3)P, is involved in regulating intracellular protein sorting reactions in eukaryotic cells...
- Bub1 is activated by the protein kinase p90(Rsk) during Xenopus oocyte maturationM S Schwab
Howard Hughes Medical Institute and Department of Pharmacology, University of Colorado, School of Medicine, 4200 East Ninth Ave, Denver, CO 80262, USA
Curr Biol 11:141-50. 2001..However, it is not known whether CSF-dependent metaphase arrest caused by p90(Rsk) involves components of the spindle assembly checkpoint...
- Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouseSalvatore Cuzzocrea
Institute of Pharmacology, School of Medicine, University of Messina, Torre Biologica Policlinico Universitario, Via C Valeria Gazzi 98100 Messina, Italy
Clin Immunol 120:57-67. 2006..These data demonstrate that GSK-3beta inhibition exerts an anti-inflammatory effect during chronic inflammation and is able to ameliorate the tissue damage associated with CIA...
- Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcriptionM P Coghlan
Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Essex, UK
Chem Biol 7:793-803. 2000..This report describes the identification and characterisation of potent and selective small molecule inhibitors of GSK-3...
- Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinaseM Delcommenne
British Columbia Cancer Agency, Jack Bell Research Centre, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6 Canada
Proc Natl Acad Sci U S A 95:11211-6. 1998..ILK is thus a receptor-proximal effector for the Pi(3)K-dependent, extracellular matrix and growth factor mediated, activation of PKB/AKT, and inhibition of GSK-3...
- Phosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcriptionLiliana Endo-Munoz
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
Virol J 2:17. 2005..Our results showed faster, greater and stronger binding of Tat to TAR RNA after phosphorylation by PKR...
- The Marek's disease virus (MDV) unique short region: alphaherpesvirus-homologous, fowlpox virus-homologous, and MDV-specific genesP Brunovskis
Department of Microbiology, Michigan State University, East Lansing 48824 1101
Virology 206:324-38. 1995..Thus, our sequence provides a foundation for further MDV studies aimed at resolving the apparent discrepancy between MDV's genetic and biologic properties...
- The barley serine/threonine kinase gene Rpg1 providing resistance to stem rust belongs to a gene family with five other members encoding kinase domainsR Brueggeman
Department of Crop and Soil Sciences, Washington State University, Pullman, WA 99164 6420, USA
Theor Appl Genet 113:1147-58. 2006..The genetic mapping, gene structures, and analysis of amino-acid sequences of the Rpg1 gene family members are presented...
- A novel transmembrane serine/threonine protein kinase gene from a rifamycin SV-producing amycolatopsis mediterranei U32W Zhang
Department of Microbiology, Shanghai Institute of Plant Physiology, Academia Sinica, Shanghai, P R China
Eur J Biochem 267:3744-52. 2000..Although its biological role is still unknown, Amk protein kinase is the first transmembrane serine/threonine protein kinase described for genus Amycolatopsis...
- Immunoprofile of mesenchymal chondrosarcoma: aberrant desmin and EMA expression, retention of INI1, and negative estrogen receptor in 22 female-predominant central nervous system and musculoskeletal casesJulie C Fanburg-Smith
Department of Orthopaedic and Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
Ann Diagn Pathol 14:8-14. 2010..including atypical teratoid tumor in the central nervous system (CNS) and rhabdomyosarcoma in the musculoskeletal (MSK) locations. We reviewed the morphology of CNS and MSK cases and applied a panel of immunostains...
- Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile vascular smooth muscle cellsP Komalavilas
Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
J Biol Chem 274:34301-9. 1999..Increased activation of these MAP kinase pathways may be one mechanism by which cGMP and PKG activation mediate c-fos induction and increased proliferation of contractile adult RASMC...
- Characterization of PDK2 activity against protein kinase B gammaConrad P Hodgkinson
Division of Biochemistry and Molecular Biology, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, United Kingdom
Biochemistry 41:10351-9. 2002....
- Glycogen synthase kinase 3beta inhibition reduces the development of nonseptic shock induced by zymosan in miceSalvatore Cuzzocrea
Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
Shock 27:97-107. 2007..This study provides the first evidence that TDZD-8 attenuates the degree of zymosan-induced, nonseptic shock in mice...
- Glycogen synthase kinase-3 regulation of chromatin segregation and cytokinesis in mouse preimplantation embryosNicole Acevedo
Department of Molecular, University of Michigan, Ann Arbor, Michigan, USA
Mol Reprod Dev 74:178-88. 2007..Inhibition of GSK-3 also resulted in abnormal chromatin segregation, evidenced by incomplete karyokinesis and micronuclei formation. These results suggest that GSK-3 activity is critical for early preimplantation embryonic development...
- Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinasesS Sturany
Abteilung Innere Medizin I and Institut für Humangenetik, Medizinische Fakultät der Universität, Ulm, Germany
J Biol Chem 276:3310-8. 2001We have isolated the full-length cDNA of a novel human serine threonine protein kinase gene...
- The HIV Dementia Scale: predictive power in mild dementia and HAARTKara Anne Bottiggi
Graduate Center for Gerontology, College of Public Health, University of Kentucky, KY, USA
J Neurol Sci 260:11-5. 2007..With the advent of highly active antiretroviral therapy (HAART), the use of sensitive and efficient screening tests for HIV-D continue to be needed for identifying individuals who develop this disorder...
- Ischemic preconditioning involves dual cardio-protective axes with p38MAPK as upstream targetNorbert Nagy
FAHA Cardiovascular Research Center, University of Connecticut School of Medicine Farmington, Cardiovascular Research Institute, CT 06030 1110, USA
J Mol Cell Cardiol 42:981-90. 2007..Since CREB is a downstream target of MSK-1 (mitogen- and stress-activated protein kinase-1) situated at the crossroad of ERK (extracellular receptor kinase) ..
- Naproxen versus acetaminophen for therapy of soft tissue injuries to the ankle in childrenVictoria A Cukiernik
Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
Ann Pharmacother 41:1368-74. 2007Musculoskeletal (MSK) ankle injuries cause significant morbidity in ambulatory pediatric populations. No optimal pharmacotherapy is available.
- Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366Gopal P Sapkota
MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U K
Biochem J 368:507-16. 2002..These observations provide the first link between ATM and LKB1 and suggest that ATM could regulate LKB1...
- Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylationK A Martin
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 276:7892-8. 2001..These data suggest a mechanism by which weak PI3-K agonists can regulate S6 phosphorylation and selective translation in the presence of mitogen-activated protein kinase signaling...
- On the physiological role of casein kinase II in Saccharomyces cerevisiaeC V Glover
Department of Biochemistry and Molecular Biology, University of Georgia, Athens 30602, USA
Prog Nucleic Acid Res Mol Biol 59:95-133. 1998....
- Integrin-linked kinase (ILK): a "hot" therapeutic targetT N Yoganathan
Kinetek Pharmaceuticals Inc, Vancouver, BC V6P6P2, Canada
Biochem Pharmacol 60:1115-9. 2000..A small molecule ILK inhibitor suppresses the phosphorylation of PKB at the Ser-473 but not the Thr-308 site in the PTEN mutant cells. These results indicate that inhibition of ILK may be of significant value in solid tumor therapy...
- Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serumM K Webster
Department of Molecular and Cell Biology, University of California, Berkeley 94720
Mol Cell Biol 13:2031-40. 1993....
- Contributory metabolic factors in the development of nephrolithiasis in patients with medullary sponge kidneyT Yagisawa
Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
Am J Kidney Dis 37:1140-3. 2001Whether specific metabolic abnormalities are related to nephrolithiasis in patients with medullary sponge kidney (MSK) remains a debated issue...
- Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasmYoshiko Katoh
Department of Biochemistry and Molecular Biology, Graduate School of Medicine H 1, Osaka University, Japan
Eur J Biochem 271:4307-19. 2004Salt-inducible kinase-1 (SIK1) is phosphorylated at Ser577 by protein kinase A in adrenocorticotropic hormone-stimulated Y1 cells, and the phospho-SIK1 translocates from the nucleus to the cytoplasm...
- Upregulation of casein kinase 1epsilon in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic painEri Sakurai
Department of Pharmacology and Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
Mol Pain 5:74. 2009..In mammals, the CK1 family consists of seven members (alpha, beta, gamma1, gamma2, gamma3, delta, and epsilon) with a highly conserved kinase domain and divergent amino- and carboxy-termini...
- The pneumococcal eukaryotic-type serine/threonine protein kinase StkP co-localizes with the cell division apparatus and interacts with FtsZ in vitroCarmen Giefing
Intercell AG, Vienna Biocenter 3, A 1030 Vienna, Austria
Microbiology 156:1697-707. 2010..Based on its cell-division-dependent localization and interaction with FtsZ, we propose that StkP plays a currently undefined role in cell division of pneumococcus...
- Medullary sponge kidney (Lenarduzzi-Cacchi-Ricci disease): a Padua Medical School discovery in the 1930sG Gambaro
Division of Nephrology, Department of Biomedical and Surgical Sciences, University Hospital of Verona, Verona, Italy
Kidney Int 69:663-70. 2006..clinical diagnostics in the 1930s enabled the discovery of several diseases, including the medullary sponge kidney (MSK)...
- The sole serine/threonine protein kinase and its cognate phosphatase from Aquifex aeolicus targets pyrimidine biosynthesisCristina Purcarea
Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, 540 E Canfield Street, Detroit, MI 48201, USA
Mol Cell Biochem 311:199-213. 2008..The Thr/Ser kinase, its cognate phosphatase and a protein substrate may be elements of a simple signaling pathway, perhaps the most primitive example of this mode of regulation described thus far...
- Induction of cortical cataracts in cultured mouse lenses with H-89, an inhibitor of protein kinase AHarold I Calvin
Department of Biochemistry, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA
Curr Eye Res 27:269-78. 2003..To compare the effects of two serine-threonine protein kinase inhibitors in a mouse lens culture system previously designed to investigate cortical cataracts caused by L-buthionine sulfoximine (BSO), inhibitor of GSH biosynthesis...
- Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylationRodrigo Jacamo
Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
J Biol Chem 283:12877-87. 2008..The present studies identify a novel mechanism induced by GPCR activation that leads to late, PKC-independent PKD activation...
- [Validity and reliability of a screening instrument for the identification of extensive work-related problems in patients with chronic diseases (SIMBO-C)]M Streibelt
Charite Universitatsmedizin Berlin
Rehabilitation (Stuttg) 48:135-44. 2009..Adequate screening instruments do exist, but publications regarding their psychometric quality across indications are still missing...
- Salt-inducible kinase 1 in the rat pinealocyte: adrenergic regulation and role in arylalkylamine N-acetyltransferase gene transcriptionR Kanyo
Department of Physiology, University of Alberta, Edmonton, Alberta, Canada
Endocrinology 150:4221-30. 2009..Here we report Sik1 expression was induced by norepinephrine (NE) in rat pinealocytes primarily through activation of beta-adrenergic ..
- [Effect of gonadotropin-releasing hormone-I agonist and gonadotropin-releasing hormone-II on endometrial carcinoma cell lines with different states of PTEN]Li jun Zhao
Department of Gynecology, Peking University People s Hospital, Beijing 100044, China
Zhonghua Fu Chan Ke Za Zhi 44:45-9. 2009..To study the effect of gonadotropin-releasing hormone-I (GnRH-I) agonist triptorelin and gonadotropin-releasing hormone-II (GnRH-II) on human endometrial carcinoma with different states of PTEN...
- Musculoskeletal education in physical medicine and rehabilitation residency programs: graduating resident perspectiveBrian J Krabak
Department of Physical Medicine and Rehabilitation, Johns Hopkins Sports Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
Am J Phys Med Rehabil 86:493-8. 2007..physical medicine and rehabilitation (PM&R) residents physicians' perceptions of their current musculoskeletal (MSK) training, to identify barriers perceived by resident physicians to improving MSK education experiences, and to ..
- Is chronic widespread pain a predictor of all-cause morbidity? A 3 year prospective population based study in family practiceUmesh T Kadam
Primary Care Sciences Research Centre, Keele University, Staffordshire, United Kingdom
J Rheumatol 32:1341-8. 2005..To investigate whether chronic widespread pain predicts illness seen in general practice in a 3 year followup period...
- Is there an urban-rural divide? Population surveys of rheumatic musculoskeletal disorders in the Pune region of India using the COPCORD Bhigwan modelVaijayanti Lagu Joshi
Center for Rheumatic Diseases, CAMP, Pune, 411 001, India
J Rheumatol 36:614-22. 2009To estimate urban prevalence of rheumatic musculoskeletal (MSK) disorders and compare to an earlier rural regional study.
- A review of the natural progression of medullary sponge kidney and a novel grading system based on intravenous urography findingsJ A Forster
Department of Urology, Pinderfields General Hospital, Mid Yorkshire Hospitals NHS Trust, Wakefield, UK
Urol Int 78:264-9. 2007Medullary sponge kidney (MSK) is a developmental abnormality of the medullary pyramids of the kidney, characterised by cystic dilatations of the collecting ducts...
- Bidirectional transcriptional activity of PGK-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout miceP C Scacheri
National Human Genome Research Institute, National Institute of Health, Bethesda, Maryland 20892, USA
Genesis 30:259-63. 2001..exons 2-4 were replaced by a PGK-neomycin cassette inserted in the opposite direction of Men1 transcription (Men1(MSK/+)). Unexpectedly, the Men1 conventional knockout was lethal in heterozygous, chimeric animals...
- Palmitate affects insulin receptor phosphorylation and intracellular insulin signal in a pancreatic alpha-cell lineSalvatore Piro
Department of Internal Medicine, University of Catania, Catania 95122, Italy
Endocrinology 151:4197-206. 2010..Our data support the hypothesis that the chronic elevation of fatty acids contribute to alpha-cell dysregulation frequently observed in type 2 diabetes...
- The physical association of casein kinase 2 with nucleolinD Li
Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 271:15662-8. 1996..At present, the physiological significance of the strong interaction between CK2 and nucleolin, an excellent substrate for the enzyme, is not clear. However, this association may be important for regulating rDNA transcription...
- Cloning and characterization of a novel serine/threonine protein kinase gene expressed predominantly in developing brainK Nara
Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
Eur J Biochem 268:2642-51. 2001..Fluorescence in situ hybridization analysis was used to map sbk to mouse chromosome 7F1-F3 and rat chromosome 1q21. These data suggest a role for SBK in signal-transduction pathways related to the control of brain development...
- Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disordersB Viollet
Departement Endocrinologie, Métabolisme et Cancer, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, and INSERM, U567, Paris, France
Diabetes Metab 33:395-402. 2007..Thus, the relationship between AMPK activation and beneficial metabolic effects provide the rationale for the development of new therapeutic strategies in metabolic disorders...
- Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in beta-amyloid peptide neurotoxicityKa Chun Suen
Laboratory of Neurodegenerative Diseases, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong
J Biol Chem 278:49819-27. 2003..Elucidation of the upstream pathways for PKR activation can help us to understand how this kinase participates in Abeta peptide neurotoxicity and to develop effective neuroprotective strategy...
- Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomasEsther Conde
Lung Cancer Group, Pathology Programme, Spanish National Cancer Centre CNIO, 28029 Madrid, Spain
Hum Pathol 38:1351-60. 2007....
- Identification, sequence analysis, and characterization of serine/threonine protein kinase 17A from Clonorchis sinensisLisi Huang
Department of Clinical Laboratory, Sun Yat sen Memorial Hospital of Sun Yat sen University, Guangzhou, 510120, People s Republic of China
Parasitol Res 113:1713-23. 2014..sinensis. Overall, these fundamental studies might contribute to further researches on signaling systems of the parasite...
- Are the predictors of work absence following a work-related injury similar for musculoskeletal and mental health claims?Peter M Smith
School of Public Health and Preventive Medicine, Monash University, Level 6, Alfred Centre, 99 Commercial Road, Melbourne, Vic, 3004, Australia
J Occup Rehabil 24:79-88. 2014To examine if the factors associated with days of absence following a work-related injury are similar for mental health versus musculoskeletal (MSK) conditions.
- Spectrum and detection of musculoskeletal findings on trauma-related CT torso examinationsJustin W Kung
Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA
Emerg Radiol 21:359-65. 2014This study aims (1) to evaluate the spectrum of musculoskeletal (MSK) findings detected on trauma-related torso CT exams performed in the emergency department and (2) to identify the findings of high clinical importance that are ..
- Calcium and calmodulin-dependent serine/threonine protein kinase type II (CaMKII)-mediated intramolecular opening of integrin cytoplasmic domain-associated protein-1 (ICAP-1α) negatively regulates β1 integrinsAngelique Millon-Fremillon
Institut Albert Bonniot U823, INSERM, F 38042 Grenoble, France
J Biol Chem 288:20248-60. 2013..Our results point to a molecular mechanism for the phosphorylation-dependent control of ICAP-1α function by CaMKII, allowing the dynamic control of β1 integrin activation and cell adhesion. ..
- Roles of several domains identified in the primary structure of salt-inducible kinase (SIK)Nanao Horike
Department of Molecular Physiological Chemistry, Osaka University Medical School, 2 2 Yamadaoka, Suita, Osaka, 565 0871 Japan
Endocr Res 28:291-4. 2002Salt-inducible kinase (SIK), a 776 amino acids-protein, contains a kinase domain in the NH2-terminal 278 amino acid residues, and the biological functions of its COOH-terminal half have yet to be clarified...
- Monte Carlo study of the effects of system geometry and antiscatter grids on cone-beam CT scatter distributionsA Sisniega
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205, USA
Med Phys 40:051915. 2013....
- Downregulation of c-myc protein by siRNA-mediated silencing of DNA-PKcs in HeLa cellsJing An
Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, Peoples Republic of China
Int J Cancer 117:531-7. 2005....
- Salt-inducible kinase 1 is involved in high glucose-induced mesangial cell proliferation mediated by the ALK5 signaling pathwayJie Yu
Department of Traditional Chinese Medicine and Endocrinology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P R China
Int J Mol Med 32:151-7. 2013..Salt-inducible kinase 1 (SIK1) prevents fibrosis by downregulating ALK5, while the expression level of the SIK1 protein itself is downregulated ..
- Three-dimensional reconstruction of the membrane skeleton at the plasma membrane interface by electron tomographyNobuhiro Morone
Kusumi Membrane Organizer Project, Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Nagoya 460 0012, Japan
J Cell Biol 174:851-62. 2006..The membrane skeleton (MSK) primarily consists of actin filaments and associated proteins...
- Discovery of potent, orally active compounds of tyrosine kinase and serine/threonine-protein kinase inhibitor with anti-tumor activity in preclinical assaysYun qing Qiu
State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, School of Medicine, Zhejiang University, 310003, Hangzhou, China
Afr J Tradit Complement Altern Med 9:431-9. 2012..The IC₅₀ value of KDR of BB1-10 is less than sorafenib. especially against c-RAF, PDGFR, c-KIT, KDR compared to sorafenib. These compounds are potent Raf1 and Flt4 kinase inhibitors...
- Exendin-4 as a stimulator of rat insulin I gene promoter activity via bZIP/CRE interactions sensitive to serine/threonine protein kinase inhibitor Ro 31-8220Oleg G Chepurny
Department of Physiology, New York University School of Medicine, New York, New York 10016, USA
Endocrinology 143:2303-13. 2002..targets PKC as as well as the 90-kDa ribosomal S6 kinase (RSK) and mitogen- and stress-activated protein kinase (MSK) family of cAMP response element-binding protein (CREB) kinases, blocked the stimulatory action of Ex-4 at RIP1-Luc...
- The role of BRAF V600 mutation in melanomaPaolo A Ascierto
Department of Melanoma, Istituto Nazionale Tumori Fondazione G, Pascale, Naples, Italy
J Transl Med 10:85. 2012....
- Novel mithramycins abrogate the involvement of protein factors in the transcription of cell cycle control genesCarolina Vizcaino
Instituto de Biologia Molecular de Barcelona, CSIC, Parc Cientific de Barcelona, Barcelona, Spain
Biochem Pharmacol 84:1133-42. 2012The effects of mithramycin SK (MSK) and demycarosyl-3D-β-D-digitoxosyl-mithramycin SK (DIG-MSK; EC-8042), two novel analogs of the antitumor antibiotic mithramycin A, on gene transcription were examined in human HCT116 colon carcinoma ..
- 3D-QSAR study of Chk1 kinase inhibitors based on dockingLingzhou Zhao
Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, 100875, China
J Mol Model 18:3669-94. 2012..The results suggested that the developed models and the obtained CHk1 inhibitor binding structures might be reliable to predict the activity of new inhibitors and reasonable for the future drug design...
- Possible role of brain salt-inducible kinase 1 in responses to central sodium in Dahl ratsBing S Huang
Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Am J Physiol Regul Integr Comp Physiol 303:R236-45. 2012..Salt-inducible kinase 1 (SIK1) increases Na(+)/K(+)-ATPase activity in kidney cells...
- Improving musculoskeletal health: global issuesGirish M Mody
Department of Rheumatology, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Congella, Durban, South Africa
Best Pract Res Clin Rheumatol 26:237-49. 2012Musculoskeletal (MSK) disorders are among the leading reasons why patients consult a family or primary health practitioner, take time off work and become disabled. Many of the MSK disorders are more common in the elderly...
- Downregulation of the renal outer medullary K(+) channel ROMK by the AMP-activated protein kinaseBalasaheb Siraskar
Department of Physiology, University of Tubingen, Tubingen, Germany
Pflugers Arch 465:233-45. 2013..In conclusion, AMPK downregulates ROMK, an effect compromising the ability of the kidney to excrete K(+) following an acute K(+) load...
- RNAi-induced K-Ras gene silencing suppresses growth of EC9706 cells and enhances chemotherapy sensitivity of esophageal cancerXin Jie Wang
Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Asian Pac J Cancer Prev 13:6517-21. 2012..and chemotherapy sensitivity of EC9706 cells after K-Ras gene silencing, an expression carrier pSilencer-siK-Ras was constructed, and the EC9706 cell line was transfected using a liposome technique...
- Mitogen-activated protein kinase p38 regulates Krox-20 to direct Schwann cell differentiation and peripheral myelinationShireen Hossain
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
Glia 60:1130-44. 2012..of p38 were explored: MAPK-activated protein kinase-2 (MK2), mitogen and stress-activated protein kinase-1 (MSK-1), and the transcription factor cAMP response element-binding protein (CREB)...
- Mammalian target of rapamycin (mTOR) inhibition reduces cerebral vasospasm following a subarachnoid hemorrhage injury in caninesWeiguang Zhang
Department of Anatomy, Shandong University School of Medicine, Shandong 250012, China
Exp Neurol 233:799-806. 2012....
- TAK-960, a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple dosing regimensYuichi Hikichi
Takeda Pharmaceutical Company Ltd, 26 1 Muraoka Higashi 2 Chome, Fujisawa, Kanagawa 251 8555, Japan
Mol Cancer Ther 11:700-9. 2012..TAK-960 has entered clinical evaluation in patients with advanced cancers...
- Targeting of renal proximal tubule Na,K-ATPase by salt-inducible kinaseMary Taub
Department of Biochemistry, University at Buffalo, 140 Farber Hall, 3435 Main Street, Buffalo, NY 14214, USA
Biochem Biophys Res Commun 393:339-44. 2010..upon the Na,K-ATPase, which is controlled by a complex regulatory network, including Salt-Inducible Protein Kinase (SIK)...
- The pro-survival function of Akt kinase can be overridden or altered to contribute to induction of apoptosisDoris Mangiaracina Benbrook
Department of Gynecologic Oncology, University of Oklahoma Health Sciences Centre, Oklahoma City, Oklahoma, 73104, USA
Curr Cancer Drug Targets 11:586-99. 2011..Upstream, caveolin-1 stimulated the pro-apoptotic function. Implications of the opposing functions of Akt in cancer therapy are discussed...
- Cognitive impairment following prenatal immune challenge in mice correlates with prefrontal cortical AKT1 deficiencyByron K Y Bitanihirwe
Laboratory of Behavioural Neurobiology, ETH Zurich, Switzerland
Int J Neuropsychopharmacol 13:981-96. 2010....
- Role of Streptococcus mutans eukaryotic-type serine/threonine protein kinase in interspecies interactions with Streptococcus sanguinisLin Zhu
College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Arch Oral Biol 55:385-90. 2010..A potential target of H2O2 is the cell-envelop of S. mutans. In the present study, the role of cell-envelop associated eukaryotic serine/threonine protein kinase (STPK) in S. mutans during interspecies competition has been investigated...
- Functional role of protein kinase B/Akt in gastric acid secretionA Todisco
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
J Biol Chem 276:46436-44. 2001..Thus, EGF induces a cascade of events in the parietal cells that results in the activation of Akt. The functional role of Akt appears to be stimulation of gastric acid secretion through induction of H(+)/K(+)-ATPase expression...
- Cerebrovascular changes in the basal ganglia with HIV dementiaJ R Berger
Department of Neurology, University of Kentucky College of Medicine, Lexington 40536 2184, USA
Neurology 54:921-6. 2000..Many investigators have proposed a contribution of a disrupted blood-brain barrier (BBB) to the pathogenesis of HIV dementia...
- Switching catalysis from hydrolysis to perhydrolysis in Pseudomonas fluorescens esteraseDe Lu Tyler Yin
Department of Biochemistry, Molecular Biology, and Biophysics and the Biotechnology Institute, University of Minnesota, 1479 Gortner Avenue, St Paul, Minnesota 55108, USA
Biochemistry 49:1931-42. 2010..we showed that a single amino acid substitution in the alcohol binding pocket, L29P, in Pseudomonas fluorescens (SIK WI) aryl esterase (PFE) increased the specificity constant of PFE for peracetic acid formation >100-fold [..
- The enhancement of the nutritive value of mango seed kernels for poultry by thermal treatment and radiation processingM D Farag
Food Irradiation Department, Radiation Processing Division, National Center for Radiation Research and Technology, Atomic Energy Authority, Nasr City, P O Box 29, Cairo, Egypt, 11371
Arch Tierernahr 54:61-79. 2001..The air-dry mango seed kernels (MSK) contained CP 70 g kg-1, EE 128 g kg-1, and tannins 67 g kg-1...
- Cellular response and activation of apoptosis by mithramycin SK in p21(WAF1)-deficient HCT116 human colon carcinoma cellsMarc Bataller
Instituto de Biologia Molecular de Barcelona, CSIC, Parc Cientific de Barcelona, Barcelona, Spain
Cancer Lett 292:80-90. 2010HCT116 (p21(-/-)) human colon carcinoma cells treated with mithramycin SK (MSK), a novel analog of the antitumor antibiotic mithramycin A (MTA), were transiently arrested in G2/M, with some cells entering a faulty mitotic cycle without ..
- Emerging treatment combinations: integrating therapy into clinical practiceSerena T Wong
The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903 2681, USA
Am J Health Syst Pharm 66:S9-S14. 2009..To review data supporting the effectiveness of emerging treatment options for metastatic breast cancer...
- The histidine-221 to tyrosine substitution in v-mos abolishes its biological function and its protein kinase activityB Singh
Department of Molecular Pathology, University of Texas System Cancer Center, M D Anderson Hospital and Tumor Institute, Houston 77030
Virology 164:114-20. 1988....
- Specific nucleoporin requirement for Smad nuclear translocationXiaochu Chen
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
Mol Cell Biol 30:4022-34. 2010..Here we identify a subset of nucleoporins that, in conjunction with Msk (Drosophila Imp7/8), specifically mediate activation-induced nuclear translocation of MAD (Drosophila Smad1) but ..
- BRK/Sik expression in the gastrointestinal tract and in colon tumorsX Llor
Department of Molecular Genetics, University of Illinois College of Medicine, Chicago 60607, USA
Clin Cancer Res 5:1767-77. 1999..intestinal cDNA library that was screened with the cDNA encoding the mouse epithelial-specific tyrosine kinase Sik. Although BRK and Sik share only 80% amino acid sequence identity, Southern blot hybridizations confirmed that the ..
- Phylogenetic and functional features of the plastid transcription kinase cpCK2 from Arabidopsis signify a role of cysteinyl SH-groups in regulatory phosphorylation of plastid sigma factorsHacer Türkeri
Laboratory of Plant Cell Physiology and Molecular Biology, University of Bochum, Universitaetsstr 150, Germany
FEBS J 279:395-409. 2012..For instance, while Cys4 but not Cys2 is essential for activity, the latter seems to be involved in the formation of intermolecular (regulatory) disulfide bonds...
- Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteinsY Nishimura
Department of Molecular and Cellular Pharmacology, Mie University School of Medicine, 2 174 Edobashi, Mie, Tsu, 514 8507, Japan
Biochem Biophys Res Commun 254:21-6. 1999..hVAP-B had VAMP-binding ability. Moreover, hVAP-A and hVAP-B associated with each other through their respective TMDs. These results suggest that complex formation by VAPs might be important in the trafficking of mammalian vesicle...
- Characterization of the cellular action of the MSK inhibitor SB-747651AShaista Naqvi
MRC Protein Phosphorylation Unit, Sir James Black Complex, University of Dundee, Dundee DD1 5EH, Scotland, U K
Biochem J 441:347-57. 2012..In cells, SB-747651A fully inhibited MSK activity at 5-10 μM...
- Identification and characterization of DBK, a novel putative serine/threonine protein kinase from human endothelial cellsW Chu
Department of Inflammation Autoimmune Diseases, Hoffmann La Roche Inc, Roche Research Center, Nutley NJ 07110 1199
Eur J Biochem 225:695-702. 1994..Using somatic cell hybrids, the DBK gene has been localized to human chromosome 14. The ubiquitous expression and high degree of conservation of DBK across species suggest that DBK may play an important role in cell functions...
- Utility and feasibility of musculoskeletal ultrasonography (MSK US) in rheumatology practice in Canada: needs assessmentMaggie J Larche
McMaster University and St Joseph s Healthcare, Suite 610, 25 Charlton Ave East, Hamilton, ON, L8N 1Y2, Canada
Clin Rheumatol 30:1277-83. 2011The utility of musculoskeletal ultrasound (MSK US) is being extensively explored and evaluated amongst European rheumatologists. However, utilization of MSK US by rheumatologists in Canada is much less common...
- DNA-PK, the DNA-activated protein kinase, is differentially expressed in normal and malignant human tissuesU Moll
Department of Pathology, State University of New York at Stony Brook, 11794, USA
Oncogene 18:3114-26. 1999..Our results suggest that the apparent absence of DNA-PKcs and Ku80 from some cells or tissues is a consequence of post-transcriptional mechanisms that regulate protein levels...
- Estrogen targets genes involved in protein processing, calcium homeostasis, and Wnt signaling in the mouse uterus independent of estrogen receptor-alpha and -betaS K Das
Department of Obstetrics and Gynecology, the Department of Molecular and Integrative Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
J Biol Chem 275:28834-42. 2000..the expression of immunoglobulin heavy chain binding protein (Bip), calpactin I (CalP), calmodulin (CalM), and Sik similar protein (Sik-SP) genes in ovariectomized wild-type or ERalpha(-/-) mice, the expression of secreted ..
- Looking upstream to understand low back pain and return to work: psychosocial factors as the product of system issuesSophie Soklaridis
University Health Network, Centre of Research Expertise in Improved Disability Outcomes, Toronto, Ontario, Canada M6J 3S3
Soc Sci Med 71:1557-66. 2010Low back pain (LBP) is the most common and expensive musculoskeletal (MSK) disorder in industrialized countries...
- Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductaseSTEPHEN WILLIAM TUTTLE; Fiscal Year: 2010..level of TxRd1 in the human squamous carcinoma cell line FaDu compared to either an oral leukoplakia cell line MSK-Leuk1 or nontransformed keratinocytes...
- Protein Kinase C and GSTP1 interactions in glioma drug resistanceFrancis Ali-Osman; Fiscal Year: 2012..The results are likely to lead to novel therapeutic strategies for malignant gliomas, particularly;those characterized by high GSTP1 expression and elevated or highly activated PKCs. ..
- Molecular mechanisms of lung disease in ataxia telangiectasiaJoAnn M Sekiguchi; Fiscal Year: 2013..abstract_text> ..
- Mechanisms of Endothelin 1-Induced Sickle Cell PathologyAlicia Rivera; Fiscal Year: 2011..We plan to characterize mechanisms of ET-1-stimulated sickle red cell dehydration as a means to develop ET-1 receptor antagonists as a novel therapy in the treatment of sickle cell disease. ..
- Herpesvirus protein kinases: Substrate recognition and pathway targeting.S Diane Hayward; Fiscal Year: 2013..Selected targets will be validated and the effect of their knockdown on virus replication determined. These experiments will uncover additional cell proteins or networks that could be targets for anti-viral therapeutic strategies. ..
- AKT Signaling and Oxidative Stress Regulation of ErythropoiesisSaghi Ghaffari; Fiscal Year: 2013..Evidence from our laboratory suggests that AKT serine threonine protein kinase mediates significant functions in the regulation of erythroid cell division and maturation downstream ..
- LKB1- AMPK pathway regulation of glucose metabolism and metformin action in liverREUBEN JAMES SHAW; Fiscal Year: 2013..In Aim 1, the role of AMPKalpha1, AMPKalpha2, and the related SIK kinases will be compared in control of hepatic glucose metabolism using novel temporally controlled genetic mouse ..
- Role of MSK1, ERa and Brf1 in alcohol-associated breast cancerShuping Zhong; Fiscal Year: 2013..which in turn causes phenotypic changes, and if inhibition of MSK1 by its chemical inhibitor and shRNA or using a MSK KO mouse blocks alcohol-induced cell transformation and Pol III gene transcription;2) if alcohol-induced H3ph ..
- Mechanism of Metformin Action in Normal and PCOS Theca CellsJan M McAllister; Fiscal Year: 2012..We will examine the role(s) of LKB1, AMPK, and the salt inducible kinases, SIK1 and SIK2, in metformin inhibition of CYP17 and CYP11A1 gene expression and androgen biosynthesis in normal and PCOS ..
- THE ROLE OF THE AKT/PKB SIGNALING IN INSULIN ACTIONMORRIS JAY BIRNBAUM; Fiscal Year: 2013..It is the aim of these studies to understand why lipid metabolism is so disturbed in Type II Diabetes Mellitus and to identify novel targets to treat this aspect of the disease. ..
- Nemo-Like Kinase and the Pathogenesis of Spinal and Bulbar Muscular AtrophyTIFFANY WERLYNE TODD; Fiscal Year: 2013....
- Protein Kinase D2 Function and Signaling in AngiogenesisHua Tang; Fiscal Year: 2012..We anticipate that these studies will provide a strong rationale for PKD2 as a novel drugable target for therapeutic intervention in angiogenesis- related human diseases. ..
- CELLS PROCESSING HIGH DENSITY LIPOPROTEINSSalman Azhar; Fiscal Year: 2013..Specifically, we propose to determine the stimulatory and inhibitory actions of SF-1/LRH-1 and NHERF1/2 and SIK-1 on SR-BI expression, SR-BI mediated selective CE transport and bile acid and steroid synthesis in liver and ..
- PKD Family Kinase Function and Signaling in Lung FibroblastsHua Tang; Fiscal Year: 2012..abstract_text> ..
- The Role of CYP1B1 in the Recurrence of Head and Neck CancerEkaterina G Shatalova; Fiscal Year: 2013..invasion, survival, apoptosis and oxidative damage) will be evaluated in cultured premalignant oral leukoplakia (MSK-Leuki) cells following exposure to B(a)P, ethanol and estrogen...
- Evaluation of the in vivo effects of genes regulating Ataxin1 levels in SCA1 miceQiumin Tan; Fiscal Year: 2013..In Aim 1, I will study the role of MSK paralogs in SCA1 pathogenesis by performing genetic studies of Msk1 and Msk2, in the SCA1 mouse model and ..
- Perturbed cell signaling network and suicide neurobiologyYogesh Dwivedi; Fiscal Year: 2013..lead to altered activation of substrates p90 ribosomal S6 kinase (RSK) and mitogen- and stress-activated kinase (MSK) and their mediated transactivation of transcription factors and chromatin remodeling;2) hypoactive ERK1/2 and PI3K ..
- SK2-associated protein kinase CK2: molecular basis and physiological rolesJohn P Adelman; Fiscal Year: 2010..In addition, drugs that decrease SK2-associated CK2 activity and thereby decrease neuronal excitability may be therapeutic avenues for treatments of hyperexcitability disorders such as schizophrenia and epilepsy. ..
- Apoptosis pathways underlying adipogenesisNiketa A Patel; Fiscal Year: 2013..By showing that alternative splicing of apoptotic genes modulate differentiation and maturation of pre-adipocytes, the proposed studies will establish a new paradigm for adipogenesis and reveal new targets for treatment of obesity. ..
- Neuroprotection in Models of Cerebral IschemiaJun Chen; Fiscal Year: 2013..A positive outcome of the project not only will have a high impact on enhancing our understanding of the basic molecular mechanisms of ischemic neuronal injury but also shed light on ASK1 as a potential therapeutic target for stroke. ..
- Exercise Regulation of Glucose Metabolism in Skeletal MuscleLaurie J Goodyear; Fiscal Year: 2012..We will test the hypothesis that AMPK-related kinases SNARK ARK5, SIK1 and MARK4 regulate glucose uptake by using novel techniques including mutagenesis and in vivo gene transfer into ..
- The role of SIK1 in myogenic differentiation and skeletal muscle repairRebecca L Berdeaux; Fiscal Year: 2013..We identified one such transcriptional target, Salt- Inducible Kinase 1 (SIK1), which is an enzyme that catalyzes phosphorylation of class II histone deacetylases and allows expression of ..
- Expression of PKG in Vascular Smooth Muscle CellsThomas M Lincoln; Fiscal Year: 2013..Specifically, a key component of this pathway (PKG) will be studied to understand how inflammation leads to these vascular disorders. ..
- Control of Vascular Cell Motility by CaMKIIHarold A Singer; Fiscal Year: 2013....
- HYPOTHERMIA AND TRAUMALarry Jenkins; Fiscal Year: 2000....
- IP3 Receptor Phosphorylation by Akt KinaseSuresh Joseph; Fiscal Year: 2006..The studies proposed in this application are significant since both signaling systems play important roles in many clinically relevant processes such as insulin and growth factor signaling, angiogenesis and oncogenesis. ..
- COMPLEMENTATION ASSAY TO SCREEN FOR KINASE INHIBITORSRICHARD EGLEN; Fiscal Year: 2004..abstract_text> ..
- E COLI TRANSLOCATION ACROSS INTESTINAL EPITHELIUMMichelle Pietzak; Fiscal Year: 2003..Under the mentorship of Kwang Sik Kim M.D., Dr...
- Regulation of Akt and glucose transport by prolactinSteven Anderson; Fiscal Year: 2006..These studies should provide important information about other roles for prolactin in the mammary gland and identify the mechanisms by which prolactin regulates these diverse processes. ..
- Mechanism of Opiate Induced Audiovestibular DysfunctionGail Ishiyama; Fiscal Year: 2006....
- Early Detection of Premalignant Lesions in Oral CancerKeiko Watanabe; Fiscal Year: 2010..The non-receptor protein tyrosine kinase BRK/Sik is an epithelial cell specific kinase that is involved in activation of cellular proliferation, differentiation and ..