Gene Symbol: SIK1
Description: salt-inducible kinase 1
Alias: EIEE30, MSK, SIK, SNF1LK, SIK-1, SNF1-like kinase, myocardial SNF1-like kinase, salt-inducible protein kinase 1, serine/threonine protein kinase, serine/threonine-protein kinase SIK1, serine/threonine-protein kinase SNF1-like kinase 1, serine/threonine-protein kinase SNF1LK
Species: human

Top Publications

  1. pmc LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    Jose M Lizcano
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 23:833-43. 2004
  2. ncbi 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK
    Abdallah K Al-Hakim
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 118:5661-73. 2005
  3. pmc LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription
    Hei Man Vincent Tang
    Department of Biochemistry, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
    Retrovirology 10:40. 2013
  4. ncbi TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain
    Hiroshi Takemori
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
    FEBS J 274:3202-9. 2007
  5. doi Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity
    Yoshiko Katoh Hashimoto
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Osaka 567 0085, Japan
    J Cell Biochem 104:1724-39. 2008
  6. ncbi Identification of novel protein kinases expressed in the myocardium of the developing mouse heart
    J C Ruiz
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138
    Mech Dev 48:153-64. 1994
  7. pmc The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation
    Mahaboobi Jaleel
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 394:545-55. 2006
  8. pmc Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways
    K T Tamai
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0606
    Mol Cell Biol 14:8155-65. 1994
  9. ncbi Physical association and functional relationship between protein kinase C zeta and the actin cytoskeleton
    J Gomez
    Centro de Investigaciones Biologicas, Madrid, Spain
    Eur J Immunol 25:2673-8. 1995
  10. ncbi Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death
    D A Cross
    Neurology Centre of Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals, Harlow, Essex, UK
    J Neurochem 77:94-102. 2001

Detail Information

Publications196 found, 100 shown here

  1. pmc LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    Jose M Lizcano
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 23:833-43. 2004
    ..A total of 12 human kinases (NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK) are related to AMPK...
  2. ncbi 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK
    Abdallah K Al-Hakim
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 118:5661-73. 2005
    ..Interestingly, the 14-3-3 isoforms bound directly to the T-loop Thr residue of QSK and SIK, after these were phosphorylated by LKB1...
  3. pmc LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription
    Hei Man Vincent Tang
    Department of Biochemistry, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
    Retrovirology 10:40. 2013
    ..Treatment options are limited and prophylactic agents are not available. We have previously demonstrated an essential role for CREB-regulating transcriptional coactivators (CRTCs) in HTLV-1 transcription...
  4. ncbi TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain
    Hiroshi Takemori
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
    FEBS J 274:3202-9. 2007
    ..In this review, we focus on the basic leucine zipper domain in the regulation of transcriptional activity of CREB and describe the functions of TORC and salt inducible kinase...
  5. doi Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity
    Yoshiko Katoh Hashimoto
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Osaka 567 0085, Japan
    J Cell Biochem 104:1724-39. 2008
    ..Salt inducible kinase 1 (SIK1) is a regulator in the feedback cascades of cAMP-mediated gene expression, while its kinase domain also features ..
  6. ncbi Identification of novel protein kinases expressed in the myocardium of the developing mouse heart
    J C Ruiz
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138
    Mech Dev 48:153-64. 1994
    ..we describe the characterization of two of the genes corresponding to the novel PCR products (designated Hek2 and msk)...
  7. pmc The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation
    Mahaboobi Jaleel
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 394:545-55. 2006
    ..Ten of the 14 AMPK-related protein kinases activated by LKB1, including SIK (salt-induced kinase), MARK (microtubule-affinity-regulating kinase) and BRSK (brain-specific kinase) isoforms, ..
  8. pmc Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways
    K T Tamai
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0606
    Mol Cell Biol 14:8155-65. 1994
    ..cerevisiae HSF responds to multiple, distinct stimuli to activate yeast metallothionein gene transcription and that these stimuli elicit responses through nonidentical, genetically separable signalling pathways...
  9. ncbi Physical association and functional relationship between protein kinase C zeta and the actin cytoskeleton
    J Gomez
    Centro de Investigaciones Biologicas, Madrid, Spain
    Eur J Immunol 25:2673-8. 1995
    ..On the contrary, zeta PKC is not involved in the actin cytoskeleton organization when cells are maintained in IL-4, confirming our previous results showing that IL-4-induced signal transduction is PKC independent...
  10. ncbi Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death
    D A Cross
    Neurology Centre of Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals, Harlow, Essex, UK
    J Neurochem 77:94-102. 2001
  11. ncbi [Cardiac, respiratory and sleep disorders in patients with myotonic dystrophy]
    Marta Banach
    Pracownia EMG, Zakładu Neurofizjologii Klinicznej, Instytutu Psychiatrii i Neurologii w Warszawie
    Przegl Lek 66:1065-8. 2009
    ..This paper is aimed at characterizing some common cardiologic and sleep related respiratory disorders of patients with myotonic dystrophy which if not recognized in good time may lead to sudden death...
  12. pmc Glycogen synthase kinase-3beta (GSK3beta) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice
    Ping Zhang
    Department of Pediatric Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294, United States
    Mol Immunol 46:677-87. 2009
    ..tularensis LVS infection, and suggest that inhibition of GSK3beta may represent a novel therapeutic approach in the treatment of tularemia...
  13. doi The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases
    Celine Forzani
    Max Perutz Laboratories, Vienna, Austria
    FEBS J 278:1126-36. 2011
    ..In addition, PTI1-4 and MPK6 were found in vivo in the same protein complex. These results demonstrate that PTI1-4 signals via OXI1 and MPK6 signalling cascades...
  14. ncbi Close association of herpes zoster reactivation and systemic lupus erythematosus (SLE) diagnosis: case-control study of patients with SLE or noninflammatory nusculoskeletal disorders
    Janet E Pope
    Division of Rheumatology, Department of Medicine, The University of Western Ontario, London, Ontario, Canada
    J Rheumatol 31:274-9. 2004
  15. ncbi Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities
    J H Stack
    Division of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego School of Medicine, La Jolla 92093 0668
    J Biol Chem 269:31552-62. 1994
    ..On the basis of the role for Vps34p in vacuolar protein sorting, we propose that the production of a specific phosphoinositide, PtdIns(3)P, is involved in regulating intracellular protein sorting reactions in eukaryotic cells...
  16. ncbi Bub1 is activated by the protein kinase p90(Rsk) during Xenopus oocyte maturation
    M S Schwab
    Howard Hughes Medical Institute and Department of Pharmacology, University of Colorado, School of Medicine, 4200 East Ninth Ave, Denver, CO 80262, USA
    Curr Biol 11:141-50. 2001
    ..However, it is not known whether CSF-dependent metaphase arrest caused by p90(Rsk) involves components of the spindle assembly checkpoint...
  17. ncbi Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
    M P Coghlan
    Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Essex, UK
    Chem Biol 7:793-803. 2000
    ..This report describes the identification and characterisation of potent and selective small molecule inhibitors of GSK-3...
  18. ncbi Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse
    Salvatore Cuzzocrea
    Institute of Pharmacology, School of Medicine, University of Messina, Torre Biologica Policlinico Universitario, Via C Valeria Gazzi 98100 Messina, Italy
    Clin Immunol 120:57-67. 2006
    ..These data demonstrate that GSK-3beta inhibition exerts an anti-inflammatory effect during chronic inflammation and is able to ameliorate the tissue damage associated with CIA...
  19. pmc Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
    M Delcommenne
    British Columbia Cancer Agency, Jack Bell Research Centre, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6 Canada
    Proc Natl Acad Sci U S A 95:11211-6. 1998
    ..ILK is thus a receptor-proximal effector for the Pi(3)K-dependent, extracellular matrix and growth factor mediated, activation of PKB/AKT, and inhibition of GSK-3...
  20. pmc Phosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcription
    Liliana Endo-Munoz
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Virol J 2:17. 2005
    ..Our results showed faster, greater and stronger binding of Tat to TAR RNA after phosphorylation by PKR...
  21. ncbi The Marek's disease virus (MDV) unique short region: alphaherpesvirus-homologous, fowlpox virus-homologous, and MDV-specific genes
    P Brunovskis
    Department of Microbiology, Michigan State University, East Lansing 48824 1101
    Virology 206:324-38. 1995
    ..Thus, our sequence provides a foundation for further MDV studies aimed at resolving the apparent discrepancy between MDV's genetic and biologic properties...
  22. ncbi The barley serine/threonine kinase gene Rpg1 providing resistance to stem rust belongs to a gene family with five other members encoding kinase domains
    R Brueggeman
    Department of Crop and Soil Sciences, Washington State University, Pullman, WA 99164 6420, USA
    Theor Appl Genet 113:1147-58. 2006
    ..The genetic mapping, gene structures, and analysis of amino-acid sequences of the Rpg1 gene family members are presented...
  23. ncbi A novel transmembrane serine/threonine protein kinase gene from a rifamycin SV-producing amycolatopsis mediterranei U32
    W Zhang
    Department of Microbiology, Shanghai Institute of Plant Physiology, Academia Sinica, Shanghai, P R China
    Eur J Biochem 267:3744-52. 2000
    ..Although its biological role is still unknown, Amk protein kinase is the first transmembrane serine/threonine protein kinase described for genus Amycolatopsis...
  24. ncbi Characterization of PDK2 activity against protein kinase B gamma
    Conrad P Hodgkinson
    Division of Biochemistry and Molecular Biology, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, United Kingdom
    Biochemistry 41:10351-9. 2002
  25. doi Immunoprofile of mesenchymal chondrosarcoma: aberrant desmin and EMA expression, retention of INI1, and negative estrogen receptor in 22 female-predominant central nervous system and musculoskeletal cases
    Julie C Fanburg-Smith
    Department of Orthopaedic and Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Ann Diagn Pathol 14:8-14. 2010
    ..including atypical teratoid tumor in the central nervous system (CNS) and rhabdomyosarcoma in the musculoskeletal (MSK) locations. We reviewed the morphology of CNS and MSK cases and applied a panel of immunostains...
  26. ncbi Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile vascular smooth muscle cells
    P Komalavilas
    Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    J Biol Chem 274:34301-9. 1999
    ..Increased activation of these MAP kinase pathways may be one mechanism by which cGMP and PKG activation mediate c-fos induction and increased proliferation of contractile adult RASMC...
  27. ncbi Glycogen synthase kinase-3 regulation of chromatin segregation and cytokinesis in mouse preimplantation embryos
    Nicole Acevedo
    Department of Molecular, University of Michigan, Ann Arbor, Michigan, USA
    Mol Reprod Dev 74:178-88. 2007
    ..Inhibition of GSK-3 also resulted in abnormal chromatin segregation, evidenced by incomplete karyokinesis and micronuclei formation. These results suggest that GSK-3 activity is critical for early preimplantation embryonic development...
  28. ncbi Glycogen synthase kinase 3beta inhibition reduces the development of nonseptic shock induced by zymosan in mice
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    Shock 27:97-107. 2007
    ..This study provides the first evidence that TDZD-8 attenuates the degree of zymosan-induced, nonseptic shock in mice...
  29. ncbi Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases
    S Sturany
    Abteilung Innere Medizin I and Institut für Humangenetik, Medizinische Fakultät der Universität, Ulm, Germany
    J Biol Chem 276:3310-8. 2001
    We have isolated the full-length cDNA of a novel human serine threonine protein kinase gene...
  30. ncbi The HIV Dementia Scale: predictive power in mild dementia and HAART
    Kara Anne Bottiggi
    Graduate Center for Gerontology, College of Public Health, University of Kentucky, KY, USA
    J Neurol Sci 260:11-5. 2007
    ..With the advent of highly active antiretroviral therapy (HAART), the use of sensitive and efficient screening tests for HIV-D continue to be needed for identifying individuals who develop this disorder...
  31. ncbi Ischemic preconditioning involves dual cardio-protective axes with p38MAPK as upstream target
    Norbert Nagy
    FAHA Cardiovascular Research Center, University of Connecticut School of Medicine Farmington, Cardiovascular Research Institute, CT 06030 1110, USA
    J Mol Cell Cardiol 42:981-90. 2007
    ..Since CREB is a downstream target of MSK-1 (mitogen- and stress-activated protein kinase-1) situated at the crossroad of ERK (extracellular receptor kinase) ..
  32. ncbi Naproxen versus acetaminophen for therapy of soft tissue injuries to the ankle in children
    Victoria A Cukiernik
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Ann Pharmacother 41:1368-74. 2007
    Musculoskeletal (MSK) ankle injuries cause significant morbidity in ambulatory pediatric populations. No optimal pharmacotherapy is available.
  33. pmc Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366
    Gopal P Sapkota
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U K
    Biochem J 368:507-16. 2002
    ..These observations provide the first link between ATM and LKB1 and suggest that ATM could regulate LKB1...
  34. ncbi Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation
    K A Martin
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:7892-8. 2001
    ..These data suggest a mechanism by which weak PI3-K agonists can regulate S6 phosphorylation and selective translation in the presence of mitogen-activated protein kinase signaling...
  35. ncbi On the physiological role of casein kinase II in Saccharomyces cerevisiae
    C V Glover
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens 30602, USA
    Prog Nucleic Acid Res Mol Biol 59:95-133. 1998
  36. ncbi Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm
    Yoshiko Katoh
    Department of Biochemistry and Molecular Biology, Graduate School of Medicine H 1, Osaka University, Japan
    Eur J Biochem 271:4307-19. 2004
    Salt-inducible kinase-1 (SIK1) is phosphorylated at Ser577 by protein kinase A in adrenocorticotropic hormone-stimulated Y1 cells, and the phospho-SIK1 translocates from the nucleus to the cytoplasm...
  37. ncbi Integrin-linked kinase (ILK): a "hot" therapeutic target
    T N Yoganathan
    Kinetek Pharmaceuticals Inc, Vancouver, BC V6P6P2, Canada
    Biochem Pharmacol 60:1115-9. 2000
    ..A small molecule ILK inhibitor suppresses the phosphorylation of PKB at the Ser-473 but not the Thr-308 site in the PTEN mutant cells. These results indicate that inhibition of ILK may be of significant value in solid tumor therapy...
  38. ncbi Contributory metabolic factors in the development of nephrolithiasis in patients with medullary sponge kidney
    T Yagisawa
    Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
    Am J Kidney Dis 37:1140-3. 2001
    Whether specific metabolic abnormalities are related to nephrolithiasis in patients with medullary sponge kidney (MSK) remains a debated issue...
  39. pmc Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum
    M K Webster
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Mol Cell Biol 13:2031-40. 1993
  40. pmc Upregulation of casein kinase 1epsilon in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain
    Eri Sakurai
    Department of Pharmacology and Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Mol Pain 5:74. 2009
    ..In mammals, the CK1 family consists of seven members (alpha, beta, gamma1, gamma2, gamma3, delta, and epsilon) with a highly conserved kinase domain and divergent amino- and carboxy-termini...
  41. doi The pneumococcal eukaryotic-type serine/threonine protein kinase StkP co-localizes with the cell division apparatus and interacts with FtsZ in vitro
    Carmen Giefing
    Intercell AG, Vienna Biocenter 3, A 1030 Vienna, Austria
    Microbiology 156:1697-707. 2010
    ..Based on its cell-division-dependent localization and interaction with FtsZ, we propose that StkP plays a currently undefined role in cell division of pneumococcus...
  42. ncbi Medullary sponge kidney (Lenarduzzi-Cacchi-Ricci disease): a Padua Medical School discovery in the 1930s
    G Gambaro
    Division of Nephrology, Department of Biomedical and Surgical Sciences, University Hospital of Verona, Verona, Italy
    Kidney Int 69:663-70. 2006
    ..clinical diagnostics in the 1930s enabled the discovery of several diseases, including the medullary sponge kidney (MSK)...
  43. doi The sole serine/threonine protein kinase and its cognate phosphatase from Aquifex aeolicus targets pyrimidine biosynthesis
    Cristina Purcarea
    Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, 540 E Canfield Street, Detroit, MI 48201, USA
    Mol Cell Biochem 311:199-213. 2008
    ..The Thr/Ser kinase, its cognate phosphatase and a protein substrate may be elements of a simple signaling pathway, perhaps the most primitive example of this mode of regulation described thus far...
  44. ncbi Induction of cortical cataracts in cultured mouse lenses with H-89, an inhibitor of protein kinase A
    Harold I Calvin
    Department of Biochemistry, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA
    Curr Eye Res 27:269-78. 2003
    ..To compare the effects of two serine-threonine protein kinase inhibitors in a mouse lens culture system previously designed to investigate cortical cataracts caused by L-buthionine sulfoximine (BSO), inhibitor of GSH biosynthesis...
  45. doi [Validity and reliability of a screening instrument for the identification of extensive work-related problems in patients with chronic diseases (SIMBO-C)]
    M Streibelt
    Charite Universitatsmedizin Berlin
    Rehabilitation (Stuttg) 48:135-44. 2009
    ..Adequate screening instruments do exist, but publications regarding their psychometric quality across indications are still missing...
  46. pmc Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylation
    Rodrigo Jacamo
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 283:12877-87. 2008
    ..The present studies identify a novel mechanism induced by GPCR activation that leads to late, PKC-independent PKD activation...
  47. doi Salt-inducible kinase 1 in the rat pinealocyte: adrenergic regulation and role in arylalkylamine N-acetyltransferase gene transcription
    R Kanyo
    Department of Physiology, University of Alberta, Edmonton, Alberta, Canada
    Endocrinology 150:4221-30. 2009
    ..Here we report Sik1 expression was induced by norepinephrine (NE) in rat pinealocytes primarily through activation of beta-adrenergic ..
  48. ncbi [Effect of gonadotropin-releasing hormone-I agonist and gonadotropin-releasing hormone-II on endometrial carcinoma cell lines with different states of PTEN]
    Li jun Zhao
    Department of Gynecology, Peking University People s Hospital, Beijing 100044, China
    Zhonghua Fu Chan Ke Za Zhi 44:45-9. 2009
    ..To study the effect of gonadotropin-releasing hormone-I (GnRH-I) agonist triptorelin and gonadotropin-releasing hormone-II (GnRH-II) on human endometrial carcinoma with different states of PTEN...
  49. ncbi Musculoskeletal education in physical medicine and rehabilitation residency programs: graduating resident perspective
    Brian J Krabak
    Department of Physical Medicine and Rehabilitation, Johns Hopkins Sports Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Am J Phys Med Rehabil 86:493-8. 2007
    ..physical medicine and rehabilitation (PM&R) residents physicians' perceptions of their current musculoskeletal (MSK) training, to identify barriers perceived by resident physicians to improving MSK education experiences, and to ..
  50. ncbi Is chronic widespread pain a predictor of all-cause morbidity? A 3 year prospective population based study in family practice
    Umesh T Kadam
    Primary Care Sciences Research Centre, Keele University, Staffordshire, United Kingdom
    J Rheumatol 32:1341-8. 2005
    ..To investigate whether chronic widespread pain predicts illness seen in general practice in a 3 year followup period...
  51. doi Is there an urban-rural divide? Population surveys of rheumatic musculoskeletal disorders in the Pune region of India using the COPCORD Bhigwan model
    Vaijayanti Lagu Joshi
    Center for Rheumatic Diseases, CAMP, Pune, 411 001, India
    J Rheumatol 36:614-22. 2009
    To estimate urban prevalence of rheumatic musculoskeletal (MSK) disorders and compare to an earlier rural regional study.
  52. ncbi Bidirectional transcriptional activity of PGK-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice
    P C Scacheri
    National Human Genome Research Institute, National Institute of Health, Bethesda, Maryland 20892, USA
    Genesis 30:259-63. 2001
    ..exons 2-4 were replaced by a PGK-neomycin cassette inserted in the opposite direction of Men1 transcription (Men1(MSK/+)). Unexpectedly, the Men1 conventional knockout was lethal in heterozygous, chimeric animals...
  53. ncbi A review of the natural progression of medullary sponge kidney and a novel grading system based on intravenous urography findings
    J A Forster
    Department of Urology, Pinderfields General Hospital, Mid Yorkshire Hospitals NHS Trust, Wakefield, UK
    Urol Int 78:264-9. 2007
    Medullary sponge kidney (MSK) is a developmental abnormality of the medullary pyramids of the kidney, characterised by cystic dilatations of the collecting ducts...
  54. doi Palmitate affects insulin receptor phosphorylation and intracellular insulin signal in a pancreatic alpha-cell line
    Salvatore Piro
    Department of Internal Medicine, University of Catania, Catania 95122, Italy
    Endocrinology 151:4197-206. 2010
    ..Our data support the hypothesis that the chronic elevation of fatty acids contribute to alpha-cell dysregulation frequently observed in type 2 diabetes...
  55. ncbi Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas
    Esther Conde
    Lung Cancer Group, Pathology Programme, Spanish National Cancer Centre CNIO, 28029 Madrid, Spain
    Hum Pathol 38:1351-60. 2007
  56. ncbi Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders
    B Viollet
    Departement Endocrinologie, Métabolisme et Cancer, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, and INSERM, U567, Paris, France
    Diabetes Metab 33:395-402. 2007
    ..Thus, the relationship between AMPK activation and beneficial metabolic effects provide the rationale for the development of new therapeutic strategies in metabolic disorders...
  57. ncbi The physical association of casein kinase 2 with nucleolin
    D Li
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 271:15662-8. 1996
    ..At present, the physiological significance of the strong interaction between CK2 and nucleolin, an excellent substrate for the enzyme, is not clear. However, this association may be important for regulating rDNA transcription...
  58. ncbi Cloning and characterization of a novel serine/threonine protein kinase gene expressed predominantly in developing brain
    K Nara
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Eur J Biochem 268:2642-51. 2001
    ..Fluorescence in situ hybridization analysis was used to map sbk to mouse chromosome 7F1-F3 and rat chromosome 1q21. These data suggest a role for SBK in signal-transduction pathways related to the control of brain development...
  59. ncbi Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect
    Borbala Gesser
    Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark
    J Invest Dermatol 127:2129-37. 2007
    ..fumaric acid esters (FAEs) on the p38 MAPK and the downstream kinases mitogen- and stress-activated protein kinase (MSK)1 and 2 in cultured human keratinocytes...
  60. ncbi Human gene profiling in response to the active protein kinase, interferon-induced serine/threonine protein kinase (PKR), in infected cells. Involvement of the transcription factor ATF-3 IN PKR-induced apoptosis
    Susana Guerra
    Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Ciudad Universitaria de Cantoblanco, E 28049 Madrid, Spain
    J Biol Chem 281:18734-45. 2006
    ..Here, we identified human genes selectively induced by expression of active PKR in infected cells and linked ATF-3 to a novel mechanism used by PKR to induce apoptosis...
  61. pmc MAST3: a novel IBD risk factor that modulates TLR4 signaling
    C Labbe
    Institut de Cardiologie de Montreal, Montreal, Quebec, Canada
    Genes Immun 9:602-12. 2008
    ..The knockdown of MAST3 specifically decreased Toll-like receptor-4-dependent NF-kappaB activity. Our findings are additional proofs of the pivotal role played by modulators of NF-kappaB activity in IBD pathogenesis...
  62. doi TORC1 regulates activity-dependent CREB-target gene transcription and dendritic growth of developing cortical neurons
    Shuai Li
    Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 29:2334-43. 2009
    ..Nuclear accumulation of TORC1 initiated the expression of CREB-target genes, including salt-inducible kinase 1 (SIK1)...
  63. pmc Activation of Akt is increased in the dysplasia-carcinoma sequence in Barrett's oesophagus and contributes to increased proliferation and inhibition of apoptosis: a histopathological and functional study
    Ian L P Beales
    Gastroenterology Unit, Norfolk and Norwich University Hospital, Norwich, UK
    BMC Cancer 7:97. 2007
    ..Therefore we have examined the activation of Akt in Barrett's oesophagus and oesophageal adenocarcinoma and the functional effects of Akt activation in vitro...
  64. ncbi Expression and characterization of a brain-specific protein kinase BSK146 from zebrafish
    Chih Ming Chou
    Department of Biochemistry, Taipei Medical University, Taipei, Taiwan
    Biochem Biophys Res Commun 340:767-75. 2006
  65. ncbi Intranuclear 3'-phosphoinositide metabolism and Akt signaling: new mechanisms for tumorigenesis and protection against apoptosis?
    Alberto M Martelli
    Dipartimento di Scienze Anatomiche Umane e Fisiopatologia dell Apparato Locomotore, Sezione di Anatomia Umana, Cell Signalling Laboratory, Universita di Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Cell Signal 18:1101-7. 2006
    ..In this review, we shall summarize the most updated and intriguing findings about nuclear PI3K/PtdIns(3,4,5)P3/Akt in relationship with tumorigenesis and suppression of apoptotic stimuli...
  66. ncbi Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals
    Jeonghee Cho
    Molecular Oncology Research Institute, Tufts New England Medical Center and Tufts Cancer Center, Boston, Massachusetts 02111, USA
    J Biol Chem 280:20442-8. 2005
    ..We conclude that Tpl2 phosphorylation at Thr(290) is induced by LPS, depends on IKKbeta, and is required for the physiological activation of Tpl2 by external signals...
  67. pmc WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade
    Jian Xie
    Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8856, USA
    J Biol Chem 288:8566-74. 2013
    ..These results indicate that WNK1 activation of the OSR1 signaling cascade is an essential pathway that regulates angiogenesis and cardiac formation during mouse embryo development...
  68. pmc AKT signalling in the failing heart
    Antoine H Chaanine
    Cardiovascular Research Center, Mount Sinai School of Medicine, New York, NY, USA
    Eur J Heart Fail 13:825-9. 2011
    ..In this review we will discuss the role of AKT in regulating signalling pathways in the heart with special emphasis on the role of AKT in modulating stress induced autophagic cell death in cardiomyocytes in vitro...
  69. doi Multistep involvement of glutathione with salicylic acid and ethylene to combat environmental stress
    Srijani Ghanta
    Plant Biology Laboratory, Drug Development Diagnostics and Biotechnology Division, CSIR Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700 032, India
    J Plant Physiol 171:940-50. 2014
    ..Together, our data revealed that GSH is involved in the synergistic multiple steps crosstalk through ET as well as SA to combat environmental stress. ..
  70. doi Aurora-A kinase inhibitor scaffolds and binding modes
    Aixia Yan
    State Key Laboratory of Chemical Resource Engineering, Department of Pharmaceutical Engineering, PO Box 53, Beijing University of Chemical Technology, 15 BeiSanHuan East Road, Beijing 100029, China
    Drug Discov Today 16:260-9. 2011
    ..Our review of the reported chemical scaffolds of Aurora-A kinase inhibitors and their binding modes could provide a useful framework from which new design strategies for inhibitors might be assessed or developed...
  71. ncbi [Infection-induced urinary stones]
    K H Bichler
    Klinik und Poliklinik fur Urologie, Eberhard Karls Universitat, Tuebingen
    Urologe A 42:47-55. 2003
    ..Pathogenetically, various risk factors play a role: urinary obstruction, neurogenic bladder, dRTA, and MSK. If these infections are not treated and the stones are not removed, the kidney will be damaged...
  72. ncbi Pim-1 phosphorylates the DNA binding domain of c-Myb
    Louise M Winn
    Department of Pharmacology and Toxicology, Botterell Hall, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Cell Cycle 2:258-62. 2003
    ..Pim-1 associated with Myb both in cells and in vitro, and phosphorylated the Myb DNA binding domain, suggesting that it regulates Myb protein activity by direct phosphorylation...
  73. doi Novel strategy for production of aggregation-prone proteins and lytic enzymes in Escherichia coli based on an anchored periplasmic expression system
    Jae Hyung Lee
    Department of Chemical and Biomolecular Engineering, KAIST, 291 Daehak ro, Yuseong Gu, Daejeon 305 701, Republic of Korea
    J Biosci Bioeng 116:638-43. 2013
    ..Two model proteins (aggregation-prone human leptin and lytic Pseudomonas fluorescens SIK W1 lipase) were examined, and both proteins were successfully produced and anchored to the inner membrane under ..
  74. ncbi Selective modulation of protein kinase C-theta during T-cell activation
    C R Monks
    Division of Basic Sciences, National Jewish Center for Immunology, Denver, Colorado 80206, USA
    Nature 385:83-6. 1997
    ..Several modes of partial T-cell activation that failed to cause PKC-theta translocation also failed to cause T-cell proliferation, further suggesting the involvement of PKC-theta in T-cell activation...
  75. ncbi Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho
    G Watanabe
    Department of Pharmacology, Kyoto University Faculty of Medicine, Japan
    Science 271:645-8. 1996
    ..This study indicates that a serine-threonine protein kinase is a Rho effector and presents an amino acid sequence motif for binding to GTP-Rho that may be shared by a family of Rho target proteins...
  76. ncbi Activation of 12-O-tetradecanoylphorbol-13-acetate response element- and dyad symmetry element-dependent transcription by interleukin-5 is mediated by Jun N-terminal kinase/stress-activated protein kinase kinases
    R P de Groot
    Department of Pulmonary Diseases, G03 550, University Hospital Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Biol Chem 272:2319-25. 1997
    ..Taken together, we show for the first time that IL-5 activates kinases of the JNK/SAPK family, and that this activation is linked to IL-5-induced TRE- and DSE-dependent transcription...
  77. ncbi Structural organization of the barley D-hordein locus in comparison with its orthologous regions of wheat genomes
    Yong Qiang Gu
    United States Department of Agriculture, Agriculture Research Service, Western Regional Research Center, Albany, CA 94710, USA
    Genome 46:1084-97. 2003
    ..These retroelements account for 63% of the contig sequence. In addition, barley D hordein was compared with wheat HMW glutenins in terms of cysteine residue conservation and repeat domain organization...
  78. pmc DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells
    Prakash Peddi
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA
    Free Radic Biol Med 48:1435-43. 2010
    ..The information rendered will be important for understanding not only cancer etiology in the presence of an NHEJ deficiency but also cancer treatments based on the induction of oxidative stress and inhibition of cluster repair...
  79. ncbi Islet of Langerhans allogeneic transplantation at the University of Geneva in the steroid free era in islet after kidney and simultaneous islet-kidney transplantations
    T Berney
    Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transplant Proc 36:1121-2. 2004
    We report a single-center experience of islet allogeneic transplantation in islet after kidney (IAK) and simultaneous islet-kidney (SIK) type 1 diabetic recipients using a steroid-free immunosuppressive regimen.
  80. doi Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice
    Vladimir R Babaev
    Atherosclerosis Research Unit, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232
    J Lipid Res 55:2296-308. 2014
    ..Our data demonstrate that loss of Akt2 suppresses the ability of macrophages to undergo M1 polarization reducing both early and advanced atherosclerosis. ..
  81. pmc TaSnRK2.4, an SNF1-type serine/threonine protein kinase of wheat (Triticum aestivum L.), confers enhanced multistress tolerance in Arabidopsis
    Xinguo Mao
    The National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China
    J Exp Bot 61:683-96. 2010
    ..4 could be utilized in transgenic breeding to improve abiotic stresses in crops...
  82. ncbi Auditory contrast versus compensation for coarticulation: data from Japanese and English listeners
    John Kingston
    Linguistics Department, University of Massachusetts, 150 Hicks Way, 226 South College, Amherst, MA 01003 9274, USA
    Lang Speech 54:499-525. 2011
    ..see text]k, [character: see text] t, sk, st] clusters arise via palatalization and vowel devoicing from /sik, sit, suk, sut/, and acoustic vestiges of the devoiced vowels remain in the fricative...
  83. doi Molecular characterization of a p38 MAPK from Litopenaeus vannamei and its expression during the molt cycle and following pathogen infection
    Shulin He
    College of Animal Science and Technology, Northwest A and F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi 712100, China
    Dev Comp Immunol 41:217-21. 2013
    ..In conclusion, we identified Lv-p38 and studied its role in pathogen infection and molting, which might facilitate our understanding of the function of p38 in innate immunity and growth during molt of shrimp...
  84. pmc Contribution of S6K1/MAPK signaling pathways in the response to oxidative stress: activation of RSK and MSK by hydrogen peroxide
    Anna Siebel
    Departament de Ciències Fisiològiques II, Campus de Bellvitge, Institut d Investigació Biomèdica de Bellvitge IDIBELL, Universitat de Barcelona, L Hospitalet de Llobregat, Barcelona, Spain Laboratório de Neuroquímica e Psicofarmacologia, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, PUCRS, Porto Alegre, Rio Grande do Sul, Brazil
    PLoS ONE 8:e75523. 2013
    ..RSK and MSK proteins were candidate targets of this phosphorylation...
  85. doi Development and validation of a high-performance liquid chromatography-tandem mass spectrometry assay quantifying vemurafenib in human plasma
    C M Nijenhuis
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Amsterdam, The Netherlands Electronic address
    J Pharm Biomed Anal 88:630-5. 2014
    ..In addition the method was successfully applied to evaluate the pharmacokinetic quantification of vemurafenib in cancer patients treated with vemurafenib. ..
  86. doi [(11)C-carbonyl]CEP-32496: radiosynthesis, biodistribution and PET study of brain uptake in P-gp/BCRP knockout mice
    Yoko Shimoda
    Molecular Probe Program, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Bioorg Med Chem Lett 24:3574-7. 2014
    ..Small-animal PET studies with [(11)C]CEP-32496 indicated that radioactivity levels (AUC0-90 min, SUV×min) accumulated in the brains of P-gp/BCRP knockout mice at a 8-fold higher rate than in the brains of wild-type mice...
  87. doi Proteome-wide discovery of unknown ATP-binding proteins and kinase inhibitor target proteins using an ATP probe
    Jun Adachi
    Laboratory of Proteome Research, National Institute of Biomedical Innovation, Ibaraki, Osaka 567 0085, Japan
    J Proteome Res 13:5461-70. 2014
    ..Using our cataloged ATP-binding protein list, a selectivity profiling method that covers the kinome and ATPome was established to identify off-target binding sites of ATP-competitive kinase inhibitors, staurosporine and crizotinib. ..
  88. doi Medullary sponge kidney associated with multivessel fibromuscular dysplasia: report of a case with renovascular hypertension
    Michele Bisceglia
    Department of Pathology, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
    Int J Surg Pathol 16:85-90. 2008
    Medullary sponge kidney (MSK) is a congenital anomaly characterized by dilatation of the collecting ducts of Bellini associated with defective urinary acidification and concentration...
  89. doi Prevalence of musculoskeletal pain in an elderly Korean population: results from the Korean Longitudinal Study on Health and Aging (KLoSHA)
    So Ra Baek
    Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Gumi dong, Bundang gu, Seongnam si, Gyeonggi do 463 707, South Korea
    Arch Gerontol Geriatr 51:e46-51. 2010
    The aim of this study is to estimate the prevalence of musculoskeletal (MSK) pain in the upper extremities (UE), low back, and lower extremities (LE) in an elderly population, and to identify related factors...
  90. doi Eps8 promotes cellular growth of human malignant gliomas
    Xiaofeng Ding
    Key Laboratory of Protein Chemistry and Developmental Biology of the State Education Ministry of China, College of Life Science, Hunan Normal University, Changsha, PR China
    Oncol Rep 29:697-703. 2013
    ..Therefore, Eps8 may represent a novel potential target in human glioma therapy...
  91. ncbi ROCK cooperated with ET-1 to induce epithelial to mesenchymal transition through SLUG in human ovarian cancer cells
    Jin Peng
    Department of Radio Chemo Therapy, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China
    Biosci Biotechnol Biochem 76:42-7. 2012
    ..Furthermore, ROCK inhibitor Y27632 reversed the increase in fibronectin induced by ET-1/ET(A)R. Our data suggest that ROCK cooperated with ET-1/ET(A)R to promote EMT of human ovarian carcinoma cells through upregulation of SLUG mRNA...
  92. doi Akt1 in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions
    Atsushi Fukai
    University of Tokyo, Tokyo, Japan
    Arthritis Rheum 62:826-36. 2010
    ..To examine the role of the phosphoinositide-dependent serine/threonine protein kinase Akt1 in chondrocytes during endochondral ossification...
  93. pmc The multikinase inhibitor sorafenib reverses the suppression of IL-12 and enhancement of IL-10 by PGE₂ in murine macrophages
    Justin P Edwards
    Sidney Kimmel Comprehensive Cancer Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Int Immunopharmacol 10:1220-8. 2010
    ..the activation of the MAP kinase p38 and its downstream target mitogen and stress activated protein kinase (MSK), and partially inhibited protein kinase B (AKT) and its subsequent inactivation of the downstream target glycogen ..
  94. doi Immunohistochemical examination of the mTORC1 pathway in high grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinomas (PCa): a tissue microarray study (TMA)
    Sevan Evren
    Department of Laboratory Medicine, University Health Network, Toronto, ON, Canada
    Prostate 70:1429-36. 2010
    ..Upregulation of this pathway can lead to an aberrant increase in cell growth and metabolism characteristic of malignant transformation...
  95. doi Dimethylfumarate inhibits NF-{kappa}B function at multiple levels to limit airway smooth muscle cell cytokine secretion
    P Seidel
    Department of Research and Pneumology, University Hospital Basel, Switzerland
    Am J Physiol Lung Cell Mol Physiol 297:L326-39. 2009
    ..Cytokine release was measured by ELISA. NF-kappaB, mitogen and stress-activated kinase (MSK-1), and CREB activation was determined by immunoblotting and EMSA...
  96. pmc An anti-urokinase plasminogen activator receptor antibody (ATN-658) blocks prostate cancer invasion, migration, growth, and experimental skeletal metastasis in vitro and in vivo
    Shafaat A Rabbani
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Neoplasia 12:778-88. 2010
    ..Results from these studies provide compelling evidence for the continued development of ATN-658 as a potential therapeutic agent for the treatment of prostate and other cancers expressing uPAR...
  97. doi Phosphoinositide-3-kinase catalytic alpha and KRAS mutations are important predictors of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in patients with advanced non-small cell lung cancer
    Vienna Ludovini
    Medical Oncology, S Maria della Misericordia Hospital, Perugia, Italy
    J Thorac Oncol 6:707-15. 2011
  98. pmc The human WW45 protein enhances MST1-mediated apoptosis in vivo
    Xuelai Luo
    Department of Surgery and Institute of Cancer Research, Tongji Hospital, Wuhan 430030, PR China
    Int J Mol Med 23:357-62. 2009
    ..These results indicate that hWW45 is required to enhance MST1-mediated apoptosis in vivo and thus is a critical player in an MST1-driven cell death signaling pathway...
  99. doi Preformulation characterization of an aluminum salt-adjuvanted trivalent recombinant protein-based vaccine candidate against Streptococcus pneumoniae
    Vidyashankara Iyer
    Bioengineering Graduate Program, University of Kansas, Lawrence, Kansas 66045, USA
    J Pharm Sci 101:3078-90. 2012
    ..PcsB was found to be stabilized when adsorbed to Alhydrogel®, and no destabilizing or stabilizing effects were seen in the case of StkP...
  100. doi Doctors likely to encounter children with musculoskeletal complaints have low confidence in their clinical skills
    Sharmila Jandial
    Musculoskeletal Research Group, Newcastle University, Newcastle upon Tyne, United Kingdom
    J Pediatr 154:267-71. 2009
    To assess self-rated confidence in pediatric musculoskeletal (pMSK) clinical assessment in trainees and experienced doctors in primary care and selected secondary care specialties to whom children with MSK problems are likely to present.
  101. doi Phosphate ion targeted colorimetric and fluorescent probe and its use to monitor endogeneous phosphate ion in a hemichannel-closed cell
    Lin E Guo
    College of Chemical Science and Technology, Yunnan University, Kunming 650091, China
    Anal Chem 87:1196-201. 2015
    ..Moreover, the utility of 1 for measuring Pi release in vitro has been demonstrated and utilized to elucidate the mechanism of Inx3 action in hemichannel-closed Sf9 cells. ..

Research Grants63

  1. Protein Kinase C and GSTP1 interactions in glioma drug resistance
    Francis Ali-Osman; Fiscal Year: 2012
    ..The results are likely to lead to novel therapeutic strategies for malignant gliomas, particularly;those characterized by high GSTP1 expression and elevated or highly activated PKCs. ..
  2. LKB1- AMPK pathway regulation of glucose metabolism and metformin action in liver
    REUBEN JAMES SHAW; Fiscal Year: 2013
    ..In Aim 1, the role of AMPKalpha1, AMPKalpha2, and the related SIK kinases will be compared in control of hepatic glucose metabolism using novel temporally controlled genetic mouse ..
  3. Herpesvirus protein kinases: Substrate recognition and pathway targeting.
    S Diane Hayward; Fiscal Year: 2013
    ..Selected targets will be validated and the effect of their knockdown on virus replication determined. These experiments will uncover additional cell proteins or networks that could be targets for anti-viral therapeutic strategies. ..
  4. Role of MSK1, ERa and Brf1 in alcohol-associated breast cancer
    Shuping Zhong; Fiscal Year: 2013
    ..which in turn causes phenotypic changes, and if inhibition of MSK1 by its chemical inhibitor and shRNA or using a MSK KO mouse blocks alcohol-induced cell transformation and Pol III gene transcription;2) if alcohol-induced H3ph ..
  5. Mechanism of Metformin Action in Normal and PCOS Theca Cells
    Jan M McAllister; Fiscal Year: 2012
    ..We will examine the role(s) of LKB1, AMPK, and the salt inducible kinases, SIK1 and SIK2, in metformin inhibition of CYP17 and CYP11A1 gene expression and androgen biosynthesis in normal and PCOS ..
  6. SK2-associated protein kinase CK2: molecular basis and physiological roles
    John P Adelman; Fiscal Year: 2010
    ..In addition, drugs that decrease SK2-associated CK2 activity and thereby decrease neuronal excitability may be therapeutic avenues for treatments of hyperexcitability disorders such as schizophrenia and epilepsy. ..
  7. mTOR, a new target for opioid-induced tolerance and hyperalgesia
    Myron Yaster; Fiscal Year: 2013
    ..Because mTOR inhibitors are FDA-approved drugs, our studies may also have a strong potential clinical application in treating and/or preventing opioid-induced analgesic tolerance and hyperalgesia. ..
  8. Molecular mechanisms of lung disease in ataxia telangiectasia
    JoAnn M Sekiguchi; Fiscal Year: 2013
    ..abstract_text> ..
  9. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2011
    ..We plan to characterize mechanisms of ET-1-stimulated sickle red cell dehydration as a means to develop ET-1 receptor antagonists as a novel therapy in the treatment of sickle cell disease. ..
  10. Evaluation of the in vivo effects of genes regulating Ataxin1 levels in SCA1 mice
    Qiumin Tan; Fiscal Year: 2013
    ..In Aim 1, I will study the role of MSK paralogs in SCA1 pathogenesis by performing genetic studies of Msk1 and Msk2, in the SCA1 mouse model and ..
  11. The role of SIK1 in myogenic differentiation and skeletal muscle repair
    Rebecca L Berdeaux; Fiscal Year: 2013
    ..We identified one such transcriptional target, Salt- Inducible Kinase 1 (SIK1), which is an enzyme that catalyzes phosphorylation of class II histone deacetylases and allows expression of ..
  12. AKT Signaling and Oxidative Stress Regulation of Erythropoiesis
    Saghi Ghaffari; Fiscal Year: 2013
    ..Evidence from our laboratory suggests that AKT serine threonine protein kinase mediates significant functions in the regulation of erythroid cell division and maturation downstream ..
  13. Improving islet transplantation outcome with Akt1
    Hongju Wu; Fiscal Year: 2013
    ..Success of this study is expected to have significant impact in the field of islet transplantation treatment for type 1 diabetes. ..
    MORRIS JAY BIRNBAUM; Fiscal Year: 2013
    ..It is the aim of these studies to understand why lipid metabolism is so disturbed in Type II Diabetes Mellitus and to identify novel targets to treat this aspect of the disease. ..
  15. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..level of TxRd1 in the human squamous carcinoma cell line FaDu compared to either an oral leukoplakia cell line MSK-Leuk1 or nontransformed keratinocytes...
  16. Nemo-Like Kinase and the Pathogenesis of Spinal and Bulbar Muscular Atrophy
    TIFFANY WERLYNE TODD; Fiscal Year: 2013
  17. Protein Kinase D2 Function and Signaling in Angiogenesis
    Hua Tang; Fiscal Year: 2012
    ..We anticipate that these studies will provide a strong rationale for PKD2 as a novel drugable target for therapeutic intervention in angiogenesis- related human diseases. ..
  18. PKD Family Kinase Function and Signaling in Lung Fibroblasts
    Hua Tang; Fiscal Year: 2012
    ..abstract_text> ..
    SHIVENDRA SHUKLA; Fiscal Year: 2009
    ..modulates p38 MAPK activity leading to downstream activation of nuclear mitogen and stress activated kinase-1 (MSK-1) and phosphorylation of histone-3 as target...
  20. Apoptosis pathways underlying adipogenesis
    Niketa A Patel; Fiscal Year: 2013
    ..By showing that alternative splicing of apoptotic genes modulate differentiation and maturation of pre-adipocytes, the proposed studies will establish a new paradigm for adipogenesis and reveal new targets for treatment of obesity. ..
  21. Neuroprotection in Models of Cerebral Ischemia
    Jun Chen; Fiscal Year: 2013
    ..A positive outcome of the project not only will have a high impact on enhancing our understanding of the basic molecular mechanisms of ischemic neuronal injury but also shed light on ASK1 as a potential therapeutic target for stroke. ..
  22. Exercise Regulation of Glucose Metabolism in Skeletal Muscle
    Laurie J Goodyear; Fiscal Year: 2012
    ..We will test the hypothesis that AMPK-related kinases SNARK ARK5, SIK1 and MARK4 regulate glucose uptake by using novel techniques including mutagenesis and in vivo gene transfer into ..
  23. Expression of PKG in Vascular Smooth Muscle Cells
    Thomas M Lincoln; Fiscal Year: 2013
    ..Specifically, a key component of this pathway (PKG) will be studied to understand how inflammation leads to these vascular disorders. ..
  24. Control of Vascular Cell Motility by CaMKII
    Harold A Singer; Fiscal Year: 2013
  25. Targeted Intervention of Breast Oncogenic Pathways
    Said M Sebti; Fiscal Year: 2013
    ..Clinical trials will be performed to evaluate the efficacy of the drug combinations. ..
  26. Role of Intestinal Cell Kinase in the Intestinal Epithelium
    Zheng Fu; Fiscal Year: 2013
  27. Development of Novel p38 MAPK Inhibitors as Therapeutics for CNS Disorders
    DANIEL MARTIN WATTERSON; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE Successful completion of the proposed investigations will provide novel, efficacious compounds required for clinical development of new therapies for neurological disorders. ..
  28. Modulation of Apoptosis in Prostate Cancer
    Khalil Ahmed; Fiscal Year: 2013
    ..Our long term goal is to take this mode of therapy to the level of translation in PC patients. ..
  29. Biochemical Mechanisms of Long-Term Potentiation
    John David Sweatt; Fiscal Year: 2013
    ..We will pursue the following three Specific Aims: 1: To test the hypothesis that the ERK/MSK pathway regulates histone methylation in the hippocampus...
  30. Role of Rho Kinases in Diabetic Nephropathy
    Farhad R Danesh; Fiscal Year: 2013
    ..We propose that inhibition of the RhoA/ROCK pathway holds promise as a novel therapeutic strategy to improve microvascular outcomes in diabetes. ..
  31. Genetic Modulation of MeHg-Induced Oxidative Stress in the Developing Brain
    Michael Aschner; Fiscal Year: 2013
    ..These specific aims hold the promise of delineating common initiator signals for the modulation of MeHg neuroprotection, shedding light on neurotoxic mechanisms and susceptibility associated with exposure to this metal. ..
  32. BUB1 in Chromosomal Instability and Tumorigenesis
    Jan M van Deursen; Fiscal Year: 2013
    ..Knowledge from these efforts could be exploited to devise novel strategies for cancer treatment and prevention in addition to conceptually advancing the fields of mitosis and cancer biology. ..
  33. Modulation of CNS Proinflammatory Cytokine Production
    Linda J Van Eldik; Fiscal Year: 2013
    ..Longer term, the knowledge generated by the proposed studies will provide a firmer foundation for future development of new classes of disease-modifying therapeutics and fuller interpretation of disease progression investigations. ..
  34. Enhancement of dendritic cell vaccine efficiency against pancreatic cancer by M--
    QIZHI C YAO; Fiscal Year: 2010
    ..This project is designed to test a central hypothesis that silencing the master immune negative regulator MSK (mitogen- and stress-activated protein kinase) in dendritic cells will allow them to be fully activated by MSLN-VLP ..
  35. IKBKE/IKKE (epsilon) Kinase in Non-small Cell Lung Cancer
    Jin Q Cheng; Fiscal Year: 2013
    Salman Azhar; Fiscal Year: 2013
    ..Specifically, we propose to determine the stimulatory and inhibitory actions of SF-1/LRH-1 and NHERF1/2 and SIK-1 on SR-BI expression, SR-BI mediated selective CE transport and bile acid and steroid synthesis in liver and ..
  37. The Role of CYP1B1 in the Recurrence of Head and Neck Cancer
    Ekaterina G Shatalova; Fiscal Year: 2013
    ..invasion, survival, apoptosis and oxidative damage) will be evaluated in cultured premalignant oral leukoplakia (MSK-Leuki) cells following exposure to B(a)P, ethanol and estrogen...
    RICHARD EGLEN; Fiscal Year: 2004
    ..abstract_text> ..
  39. Perturbed cell signaling network and suicide neurobiology
    Yogesh Dwivedi; Fiscal Year: 2013
    ..lead to altered activation of substrates p90 ribosomal S6 kinase (RSK) and mitogen- and stress-activated kinase (MSK) and their mediated transactivation of transcription factors and chromatin remodeling;2) hypoactive ERK1/2 and PI3K ..
  40. Role and Regulation of Sodium, Potasium ATPase in Lung
    Jacob I Sznajder; Fiscal Year: 2013
    ..specific aims: in studies proposed for Specific Aim 1 we will determine whether the salt inducible kinase (SIK) participates in the GPCR mediated Na,K-ATPase upregulation by facilitating the traffic of Na+ pump molecules from ..
  41. In Vivo Imaging-Based Multiscale Modeling of Normal and Atrophied Human Lower Leg
    Shantanu Sinha; Fiscal Year: 2013
    ..integrated array of imaging techniques will characterize comprehensively, the multi- component musculoskeletal (MSK) architecture and function of the lower leg, in normal, atrophied and at various stages of recuperation in these ..
  42. Integrating Tobacco Treatment into Cancer Care
    Elyse R Park; Fiscal Year: 2013
    ..breast, or prostate cancer (the four most prevalent cancers) at MGH and Memorial Sloan Kettering Cancer Center (MSK) and compare the differential effectiveness of delivering an Intensive Treatment (IT;10 motivational counseling ..
  43. Patient Oriented Research and Mentoring Program in Orthopedics
    Elena Losina; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Musculoskeletal (MSK) disorders represent a broad group of conditions with diverse etiologies that result in pain and functional impairment of bones, joints, tendons, ligaments and/or muscles...
  44. Dynamic regulation of hepatic SIK1 during fasting and feeding
    Rebecca L Berdeaux; Fiscal Year: 2013 mouse models and cultured hepatocytes implicated a family of AMPK-related kinases called Salt-Inducible Kinases (SIK1-3), in the control of CRTC co-activator function during fasting and re-feeding...
  45. Image Science for the New X-Ray: Taking Dual-Energy CT to Task
    Jeffrey H Siewerdsen; Fiscal Year: 2013
    ..Application of DE-CT is seen in abdominal (e.g., renal calculi), musculoskeletal (MSK, e.g., arthritis), and neuro (e.g., perfusion) imaging...
  46. Severity Scale and Quality of Life Instrument for Infantile Hemangiomas
    ..Topic, 05-AR-102: Comparative Effectiveness (CE) of Treatments for Chronic Childhood Arthritis and Musculoskeletal (MSK) and Skin Disease...
    Sanjoy K Das; Fiscal Year: 2012
    ..Our previous and preliminary observations suggest that among several such early genes, Bip and Sik-SP are induced by estradiol- 172 (E2) and kepone in the mouse uterus via ER-independent manner as a phase-I ..
  48. Ca2+ Stimulation of MAP Kinase and Neuroplasticity
    Daniel R Storm; Fiscal Year: 2013
    ..We also discovered that MAPK, PKA, and MSK-1, a CREB kinase, are coactivated in the same subset of neurons in the area CA1 of the hippocampus during memory ..
  49. Memory Enhancement by A Genetic Increase in cAMP Signals
    Daniel R Storm; Fiscal Year: 2013
    ..that the stronger memory exhibited by young AC1+ mice may be due to enhanced signaling through the cAMP/MAPK/ MSK-1/CREB signaling pathway as well as amplification of the circadian oscillation of this pathway...
  50. Reversing genetically modified T cell suppression in a model of liver metastases
    Steven C Katz; Fiscal Year: 2013
    ..I spent two years as a research fellow with Dr. Ronald DeMatteo at Memorial Sloan-Kettering (MSK), where I gained valuable experience in immunologic research and published papers on liver immune cells in ..
    Larry Jenkins; Fiscal Year: 2000
  52. Image Overlay for MRI-Guided Needle Insertions
    JOHN ANTHONY CARRINO; Fiscal Year: 2010
    ..3) Perform clinical system performance evaluation trial on human subjects in joint arthrography, MSK biopsy (sarcoma), vertebral biopsy, and disk space aspiration procedures...
  53. The TCGA Cancer Genome Characterization Center at MSKCC
    Marc Ladanyi; Fiscal Year: 2009
    The TCGA Cancer Genome Characterization Center at MSKCC (designated herein MSK-CGCC) will provide comprehensive profiling of gene expression (whole transcript, exon-level, and microRNA) and of genomic gains and losses (whole genome, and ..
    Michelle Pietzak; Fiscal Year: 2003
    ..Under the mentorship of Kwang Sik Kim M.D., Dr...
  55. Regulation of Akt and glucose transport by prolactin
    Steven Anderson; Fiscal Year: 2006
    ..These studies should provide important information about other roles for prolactin in the mammary gland and identify the mechanisms by which prolactin regulates these diverse processes. ..
  56. Mechanism of Opiate Induced Audiovestibular Dysfunction
    Gail Ishiyama; Fiscal Year: 2006
  57. Early Detection of Premalignant Lesions in Oral Cancer
    Keiko Watanabe; Fiscal Year: 2010
    ..The non-receptor protein tyrosine kinase BRK/Sik is an epithelial cell specific kinase that is involved in activation of cellular proliferation, differentiation and ..
    Fouad Kandeel; Fiscal Year: 2006
    ..overall objective of this research application is to establish clinical protocols for simultaneous islet-kidney (SIK) transplantation in type 1 diabetic recipients that will provide long-term euglycemia and insulin-independence...
  59. Role of PID Kinase in Auxin Regulation
    Sioux Christensen; Fiscal Year: 2006
    ..abstract_text> ..
  60. Molecular mechanisms of synapse lose by polo kinases
    Daniel T Pak; Fiscal Year: 2010
    ..abstract_text> ..
    Michael McDaniel; Fiscal Year: 2007
    ..abstract_text> ..
  62. BRK/Sik Tyrosine Kinase Signaling in the Prostate
    ANGELA TYNER; Fiscal Year: 2009
    The intracellular epithelial-specific tyrosine kinase BRK/Sik belongs to a tyrosine kinase family whose members have growth inhibitory functions...
  63. IP3 Receptor Phosphorylation by Akt Kinase
    Suresh Joseph; Fiscal Year: 2006
    ..The studies proposed in this application are significant since both signaling systems play important roles in many clinically relevant processes such as insulin and growth factor signaling, angiogenesis and oncogenesis. ..