Gene Symbol: sialoadhesin
Description: sialic acid binding Ig like lectin 1
Alias: CD169, SIGLEC-1, dJ1009E24.1, sialoadhesin, sialic acid binding Ig-like lectin 1, sialoadhesin, sialic acid-binding immunoglobulin-like lectin 1
Species: human
Products:     sialoadhesin

Top Publications

  1. Nath D, Hartnell A, Happerfield L, Miles D, Burchell J, Taylor Papadimitriou J, et al. Macrophage-tumour cell interactions: identification of MUC1 on breast cancer cells as a potential counter-receptor for the macrophage-restricted receptor, sialoadhesin. Immunology. 1999;98:213-9 pubmed
    ..Here we demonstrate in primary human breast cancers that sialoadhesin (Sn), a macrophage-restricted adhesion molecule, is frequently expressed on infiltrating cells that often make ..
  2. van den Berg T, Nath D, Ziltener H, Vestweber D, Fukuda M, Van Die I, et al. Cutting edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor sialoadhesin (Siglec-1). J Immunol. 2001;166:3637-40 pubmed
    b>Sialoadhesin (Siglec-1) is a macrophage-restricted sialic acid-binding receptor that mediates interactions with hemopoietic cells, including lymphocytes. In this study, we identify sialoadhesin counterreceptors on T lymphocytes...
  3. Kirchberger S, Majdic O, Steinberger P, Bluml S, Pfistershammer K, Zlabinger G, et al. Human rhinoviruses inhibit the accessory function of dendritic cells by inducing sialoadhesin and B7-H1 expression. J Immunol. 2005;175:1145-52 pubmed
    ..In contrast, expression of inhibitory B7-H1 molecules was up-regulated and R-DC de novo expressed sialoadhesin (Sn)...
  4. van der Kuyl A, van den Burg R, Zorgdrager F, Groot F, Berkhout B, Cornelissen M. Sialoadhesin (CD169) expression in CD14+ cells is upregulated early after HIV-1 infection and increases during disease progression. PLoS ONE. 2007;2:e257 pubmed
    b>Sialoadhesin (CD169, siglec-1 or Sn) is an activation marker seen on macrophages in chronic inflammatory diseases and in tumours, and on subsets of tissue macrophages...
  5. Izquierdo Useros N, Lorizate M, Puertas M, Rodriguez Plata M, Zangger N, Erikson E, et al. Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides. PLoS Biol. 2012;10:e1001448 pubmed publisher
    ..Here we show that the sialic acid-binding Ig-like lectin 1 (Siglec-1, CD169), which is highly expressed on mature DCs, specifically binds HIV-1 and vesicles carrying sialyllactose...
  6. York M, Nagai T, Mangini A, Lemaire R, van Seventer J, Lafyatis R. A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists. Arthritis Rheum. 2007;56:1010-20 pubmed
    ..SSc patients showed increased expression of a cluster of IFN-regulated genes, including Siglec-1 (CD169, sialoadhesin)...
  7. Biesen R, Demir C, Barkhudarova F, Grün J, Steinbrich Zöllner M, Backhaus M, et al. Sialic acid-binding Ig-like lectin 1 expression in inflammatory and resident monocytes is a potential biomarker for monitoring disease activity and success of therapy in systemic lupus erythematosus. Arthritis Rheum. 2008;58:1136-45 pubmed publisher
    ..Levels of sialic acid-binding Ig-like lectin 1 (Siglec-1) (sialoadhesin, CD169) in inflammatory and resident monocytes were determined at the protein level in 38 healthy controls and ..
  8. Puryear W, Akiyama H, Geer S, Ramirez N, Yu X, Reinhard B, et al. Interferon-inducible mechanism of dendritic cell-mediated HIV-1 dissemination is dependent on Siglec-1/CD169. PLoS Pathog. 2013;9:e1003291 pubmed publisher
    ..Here, we demonstrate that the type I IFN-inducible Siglec-1, CD169, is the DC receptor that captures HIV in a GM3-dependent manner...
  9. Hartnell A, Steel J, Turley H, Jones M, Jackson D, Crocker P. Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations. Blood. 2001;97:288-96 pubmed
    b>Sialoadhesin is a macrophage-restricted cellular interaction molecule and a prototypic member of the Siglec family of sialic acid binding immunoglobulin (Ig)-like lectins. So far, it has only been characterized in rodents...

More Information

Publications111 found, 100 shown here

  1. Rempel H, Calosing C, Sun B, Pulliam L. Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivity. PLoS ONE. 2008;3:e1967 pubmed publisher
    ..expression analysis of CD14(+) monocytes from subjects infected with HIV-1 revealed increased expression of sialoadhesin (Sn, CD169, Siglec 1), a cell adhesion molecule first described in a subset of macrophages activated in chronic ..
  2. Heideveld E, Hampton O Neil L, Cross S, van Alphen F, van den Biggelaar M, Toye A, et al. Glucocorticoids induce differentiation of monocytes towards macrophages that share functional and phenotypical aspects with erythroblastic island macrophages. Haematologica. 2018;103:395-405 pubmed publisher
    ..cell factor, erythropoietin, lipids and dexamethasone differentiate towards macrophages expressing CD16, CD163, CD169, CD206, CXCR4 and the phagocytic TAM-receptor family...
  3. Kounis N, Hahalis G. Serum IgE levels in coronary artery disease. Atherosclerosis. 2016;251:498-500 pubmed publisher
    ..Inducible macrophage protein 1a may activate mast cells, while CD169+ macrophages activate CD8 T cells...
  4. Phongsisay V. The immunobiology of Campylobacter jejuni: Innate immunity and autoimmune diseases. Immunobiology. 2016;221:535-43 pubmed publisher
    ..Several lines of evidence from animal models of autoimmune diseases suggest that simultaneous activation of innate immunity in the presence of autoreactive lymphocytes or antigen mimicry may link C. jejuni to immunopathology. ..
  5. Gonçalves J, Leitão R, Higuera Matas A, Assis M, Coria S, Fontes Ribeiro C, et al. Extended-access methamphetamine self-administration elicits neuroinflammatory response along with blood-brain barrier breakdown. Brain Behav Immun. 2017;62:306-317 pubmed publisher
    ..intercellular adhesion molecule, concomitant with the presence of T cell antigen CD4 and tissue macrophage marker CD169 in the brain parenchyma...
  6. Du X, Wu Z, Xu Y, Liu Y, Liu W, Wang T, et al. Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice. Cell Mol Immunol. 2018;: pubmed publisher MCD mice, including F4/80+CD11b+, F4/80+CD68+, and F4/80+CD169+ macrophages...
  7. Dong J, Wei Y, Ye X, Sun C, Tian Y, Lu M, et al. Discovery and expression of 3 siglecs-like in Oreochromis niloticus neutrophil, and their interaction with group B streptococcal sialylated capsular polysaccharides. Mol Immunol. 2016;73:158-69 pubmed publisher
    ..GBS infections led to significant changes in Siglecs-like expression in immune-related tissues. However, immunostimulation or immunosuppression via the recognition of GBS by different Siglecs-like molecules requires additional studies. ..
  8. Bajwa A, Huang L, Kurmaeva E, Gigliotti J, Ye H, Miller J, et al. Sphingosine 1-Phosphate Receptor 3-Deficient Dendritic Cells Modulate Splenic Responses to Ischemia-Reperfusion Injury. J Am Soc Nephrol. 2016;27:1076-90 pubmed publisher
    ..Additionally, S1pr3(-/-) BMDC-dependent protection required CD169(+)marginal zone macrophages and the macrophage-derived chemokine CCL22 to increase splenic CD4(+)Foxp3(+) T(REG)s...
  9. Redelinghuys P, Antonopoulos A, Liu Y, Campanero Rhodes M, McKenzie E, Haslam S, et al. Early murine T-lymphocyte activation is accompanied by a switch from N-Glycolyl- to N-acetyl-neuraminic acid and generation of ligands for siglec-E. J Biol Chem. 2011;286:34522-32 pubmed publisher
    ..In contrast, much lower levels of T cell binding were observed with other siglecs, including sialoadhesin, CD22, and siglec-F and the plant lectins Maackia amurensis leukoagglutinin and Sambucus nigra agglutinin...
  10. Caballero I, Yen J, Hensley L, Honko A, Goff A, Connor J. Lassa and Marburg viruses elicit distinct host transcriptional responses early after infection. BMC Genomics. 2014;15:960 pubmed publisher
  11. Shi C, Liu Y, Ding Y, Zhang Y, Zhang J. PRRSV receptors and their roles in virus infection. Arch Microbiol. 2015;197:503-12 pubmed publisher
    ..Up to now, heparin sulfate, sialoadhesin, CD163, CD151 and vimentin have been identified as the important PRRSV receptors via their involvement in virus ..
  12. Ren X, Ji Y, Jiang X, Qi X. Down-regulation of siglec-2 (CD22) predicts worse overall survival from HBV-related early-stage hepatocellular carcinoma: a preliminary analysis from Gene Expression Omnibus. Biosci Rep. 2018;38: pubmed publisher
    ..05). In conclusion, up-regulation of siglec-2 in tumor tissues could predict better OS in HCC patients. Mechanisms of siglec-2 in HCC development need further research. ..
  13. Dutta P, Hoyer F, Grigoryeva L, Sager H, Leuschner F, Courties G, et al. Macrophages retain hematopoietic stem cells in the spleen via VCAM-1. J Exp Med. 2015;212:497-512 pubmed publisher
    ..Both, depleting macrophages in CD169 iDTR mice or silencing VCAM-1 in macrophages released HSCs from the spleen...
  14. Spaulding E, Fooksman D, Moore J, Saidi A, Feintuch C, Reizis B, et al. STING-Licensed Macrophages Prime Type I IFN Production by Plasmacytoid Dendritic Cells in the Bone Marrow during Severe Plasmodium yoelii Malaria. PLoS Pathog. 2016;12:e1005975 pubmed publisher
    ..This robust type I IFN production required priming of pDCs by CD169+ macrophages undergoing activation upon STING-mediated sensing of parasites in the bone marrow...
  15. Ballweg I, Frolich K, Fandrey E, Kliem H, Pfaffl M. Comparison of the immune competence of Turopolje, German Landrace × Turopolje, and German Landrace × Pietrain pigs after PRRSV vaccination. Vet Immunol Immunopathol. 2016;174:35-44 pubmed publisher
    ..In contrast, the two other breeds (L×T and L×P) showed a type 2 immune response, which resulted in the higher synthesis of B-cells and an increased concentration of specific anti-PRRS MLV antibodies. ..
  16. Pilling D, Galvis Carvajal E, Karhadkar T, Cox N, Gomer R. Monocyte differentiation and macrophage priming are regulated differentially by pentraxins and their ligands. BMC Immunol. 2017;18:30 pubmed publisher
    ..regulate the expression of the hemoglobin-haptoglobin complex receptor CD163, the sialic acid-binding lectin CD169, and the macrophage mannose receptor CD206...
  17. Miyashita A, Fukushima S, Nakahara S, Kubo Y, Tokuzumi A, Yamashita J, et al. Immunotherapy against Metastatic Melanoma with Human iPS Cell-Derived Myeloid Cell Lines Producing Type I Interferons. Cancer Immunol Res. 2016;4:248-58 pubmed publisher
    ..The iPS-ML-IFNs increased the expression of CD169, a marker of M1 macrophages that can activate antitumor immunity...
  18. Ferreira R, Guo H, Coulson R, Smyth D, Pekalski M, Burren O, et al. A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes. Diabetes. 2014;63:2538-50 pubmed publisher
    ..0064), and marked by increased expression of SIGLEC-1 (CD169), a lectin-like receptor expressed on CD14(+) monocytes...
  19. Desbien A, Dubois Cauwelaert N, Reed S, Bailor H, Liang H, Carter D, et al. IL-18 and Subcapsular Lymph Node Macrophages are Essential for Enhanced B Cell Responses with TLR4 Agonist Adjuvants. J Immunol. 2016;197:4351-4359 pubmed
    ..b>CD169+ SIGNR1+ subcapsular medullary macrophages are the primary cells to take up GLA-SE after ..
  20. Xu X, Bian L, Shen M, Li X, Zhu J, Chen S, et al. Multipeptide-coupled nanoparticles induce tolerance in 'humanised' HLA-transgenic mice and inhibit diabetogenic CD8+ T cell responses in type 1 diabetes. Diabetologia. 2017;60:2418-2431 pubmed publisher
    ..and accumulation of regulatory T cells and CD11c+ dendritic cells through a rapid production of CD169+ macrophage-derived C-C motif chemokine 22 (CCL22)...
  21. Wei Q, Boulais P, Zhang D, Pinho S, Tanaka M, Frenette P. Maea expressed by macrophages, but not erythroblasts, maintains postnatal murine bone marrow erythroblastic islands. Blood. 2019;: pubmed publisher
    ..Deletion of Maea in macrophages using Csf1r-Cre or CD169-Cre caused severe reductions of bone marrow (BM) macrophages, erythroblasts, and in vivo island formation, ..
  22. Lescoat A, Ballerie A, Augagneur Y, Morzadec C, Vernhet L, Fardel O, et al. Distinct Properties of Human M-CSF and GM-CSF Monocyte-Derived Macrophages to Simulate Pathological Lung Conditions In Vitro: Application to Systemic and Inflammatory Disorders with Pulmonary Involvement. Int J Mol Sci. 2018;19: pubmed publisher
    ..Globally, AM phenotype was closer to GM-CSF MDMs. However, the expression levels of CD163, CD169, CD204, CD64 and CD36 were significantly higher in SSc-ILD than in lung cancers...
  23. Zheng J, Jia L, Mori S, Kodama T. Evaluation of metastatic niches in distant organs after surgical removal of tumor-bearing lymph nodes. BMC Cancer. 2018;18:608 pubmed publisher
    ..The tumor cells in the PALN of control groups were significantly higher than in the SiLN removal groups, and CD169+ and CD11c+ cells were also higher than in the SiLN removal groups...
  24. Li Y, Darwich L, Mateu E. Characterization of the attachment and infection by Porcine reproductive and respiratory syndrome virus 1 isolates in bone marrow-derived dendritic cells. Vet Microbiol. 2018;223:181-188 pubmed publisher
    ..isolates were seen attached to iBMDC even in cells lacking CD163 -the essential receptor for PRRSV- or porcine sialoadhesin (PoSn). The attachment was not fully avoided after removal of heparan sulphate by heparinase I...
  25. Li J, Tao S, Orlando R, Murtaugh M. N-glycosylation profiling of porcine reproductive and respiratory syndrome virus envelope glycoprotein 5. Virology. 2015;478:86-98 pubmed publisher
    ..Our findings help to explain PRRSV infection of cells lacking sialoadhesin and provide a glycan database to facilitate molecular structural studies of PRRSV.
  26. Hulme H, Meikle L, Wessel H, Strittmatter N, Swales J, Thomson C, et al. Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection. Sci Rep. 2017;7:2786 pubmed publisher
    ..High levels of PalC localised to sites within the MLNs where B and T cells were absent and where the perimeter of CD169+ sub capsular sinus macrophages was disrupted...
  27. Duriancik D, Gardner E. Energy restriction impairs dendritic cell development in C57BL/6J mice. Mech Ageing Dev. 2016;154:9-19 pubmed publisher
    ..Furthermore, we observed increased macrophages and cells expressing CD169 in the bone marrow of ER mice...
  28. Garba A, Acar D, Roukaerts I, Desmarets L, Devriendt B, Nauwynck H. Long-term culture and differentiation of porcine red bone marrow hematopoietic cells co-cultured with immortalized mesenchymal cells. Vet Immunol Immunopathol. 2017;191:44-50 pubmed publisher
    ..three weeks of co-culture, flow cytometry analysis showed an increased surface expression of CD172a, CD14, CD163, CD169, CD4 and CD8 up to 37±0.8%, 40±8%, 41±4%, 23±3% and 19±5% of the hematopoietic cells, respectively...
  29. Liu Y, Yu M, Chai Y, Shou S. Sialic Acids in the Immune Response during Sepsis. Front Immunol. 2017;8:1601 pubmed publisher
    ..Regulating the Siglecs function in the different stages of sepsis holds great potential in the therapy of sepsis...
  30. Bumb A, Regino C, Egen J, Bernardo M, Dobson P, Germain R, et al. Trafficking of a dual-modality magnetic resonance and fluorescence imaging superparamagnetic iron oxide-based nanoprobe to lymph nodes. Mol Imaging Biol. 2011;13:1163-72 pubmed publisher its passive migration from the intradermal injection site and its minimal uptake by CD11c+ dendritic cells and CD169+ and lys+ macrophages...
  31. Frydas I, Trus I, Kvisgaard L, Bonckaert C, Reddy V, Li Y, et al. Different clinical, virological, serological and tissue tropism outcomes of two new and one old Belgian type 1 subtype 1 porcine reproductive and respiratory virus (PRRSV) isolates. Vet Res. 2015;46:37 pubmed publisher
    ..13V117 infection resulted in the lowest virus replication in lymphoid tissues. 13V091 showed higher numbers of sialoadhesin(-) infected cells/mm(2) in conchae, tonsils and spleen than 13V117 and 07V063...
  32. Asano K, Takahashi N, Ushiki M, Monya M, Aihara F, Kuboki E, et al. Intestinal CD169(+) macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes. Nat Commun. 2015;6:7802 pubmed publisher
    ..Here we show that CD169(+) macrophages reside not at the villus tip, but at the bottom-end of the LP microenvironment...
  33. Sautter C, Auray G, Python S, Liniger M, Summerfield A. Phenotypic and functional modulations of porcine macrophages by interferons and interleukin-4. Dev Comp Immunol. 2018;84:181-192 pubmed publisher
    ..IFNβ induced CD169, MHC class I, CD40, CD80/86, but suppressed IL-6, IL-12 and tumor-necrosis-factor secretion...
  34. Wang B, Liu H, Dong X, Wu S, Zeng H, Liu Z, et al. High CD204+ tumor-infiltrating macrophage density predicts a poor prognosis in patients with urothelial cell carcinoma of the bladder. Oncotarget. 2015;6:20204-14 pubmed
    ..assessed by immunohistochemistry in tissues from 302 UCB patients using CD68 as a pan-Mφ marker, and CD204 and CD169 as robust pro- and anti-tumoral Mφ phenotype markers, respectively...
  35. Pucci F, Garris C, Lai C, Newton A, Pfirschke C, Engblom C, et al. SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions. Science. 2016;352:242-6 pubmed publisher that endogenous tEVs efficiently disseminate via lymphatics and preferentially bind subcapsular sinus (SCS) CD169(+) macrophages in tumor-draining lymph nodes (tdLNs) in mice and humans...
  36. Wu Y, Lan C, Ren D, Chen G. Induction of Siglec-1 by Endotoxin Tolerance Suppresses the Innate Immune Response by Promoting TGF-?1 Production. J Biol Chem. 2016;291:12370-82 pubmed publisher
    ..Thus, Siglec-1 plays an important role in the development of endotoxin tolerance and targeted manipulation of this process could lead to a new therapeutic opportunity for patients with sepsis. ..
  37. De Schryver M, Leemans A, Pintelon I, Cappoen D, Maes L, Caljon G, et al. Comparative analysis of the internalization of the macrophage receptor sialoadhesin in human and mouse primary macrophages and cell lines. Immunobiology. 2017;222:797-806 pubmed publisher
    b>Sialoadhesin (Sn) is a surface receptor expressed on resident macrophages with the ability to bind with sialic acids. During inflammation, an upregulation of Sn is observed...
  38. Erikson E, Wratil P, Frank M, Ambiel I, Pahnke K, Pino M, et al. Mouse Siglec-1 Mediates trans-Infection of Surface-bound Murine Leukemia Virus in a Sialic Acid N-Acyl Side Chain-dependent Manner. J Biol Chem. 2015;290:27345-59 pubmed publisher
    Siglec-1 (sialoadhesin, CD169) is a surface receptor on human cells that mediates trans-enhancement of HIV-1 infection through recognition of sialic acid moieties in virus membrane gangliosides...
  39. Wilhelm T, Taddeo A, Winter O, Schulz A, Mälzer J, Domingo C, et al. Siglec-1-positive plasmacytoid dendritic cells (pDCs) in human peripheral blood: A semi-mature and myeloid-like subset imbalanced during protective and autoimmune responses. Clin Immunol. 2016;163:42-51 pubmed publisher
    ..PDCs can be subdivided into two subsets according to Siglec-1 expression. These subsets may play specific roles in (auto)immune responses. ..
  40. Li J, Yu X, Wang Y, Huang L, Liu C, Zheng L, et al. Distinct patterns and prognostic values of tumor-infiltrating macrophages in hepatocellular carcinoma and gastric cancer. J Transl Med. 2017;15:37 pubmed publisher
    ..In HCC, most CD68+ Mφs were CD204+ and CD169+ cells in the NT region; however, there was a significant decrease in the percentage of CD169+
  41. Saito Y, Ohnishi K, Miyashita A, Nakahara S, Fujiwara Y, Horlad H, et al. Prognostic Significance of CD169+ Lymph Node Sinus Macrophages in Patients with Malignant Melanoma. Cancer Immunol Res. 2015;3:1356-63 pubmed publisher
    CD169 (sialoadhesin) is a sialic acid receptor that is specifically expressed on macrophages, including lymph node sinus macrophages. Animal studies suggest that CD169(+) macrophages in lymph nodes have properties in preventing cancers...
  42. Strauß R, Rose T, Flint S, Klotsche J, Häupl T, Peck Radosavljevic M, et al. Type I interferon as a biomarker in autoimmunity and viral infection: a leukocyte subset-specific analysis unveils hidden diagnostic options. J Mol Med (Berl). 2017;95:753-765 pubmed publisher
    ..Very similar leukocyte subsets reveal distinctive IFN signatures. IFN alpha mixes up composition of blood and leads to a preferential neutropenia, yielding relative lymphocytosis. ..
  43. Roy S, Mandal C. Leishmania donovani Utilize Sialic Acids for Binding and Phagocytosis in the Macrophages through Selective Utilization of Siglecs and Impair the Innate Immune Arm. PLoS Negl Trop Dis. 2016;10:e0004904 pubmed publisher
    ..To the best of our knowledge, this is a comprehensive report describing sialic acids-siglec interactions and their role in facilitating uptake of the virulent parasite within the host. ..
  44. Novakovic P, Harding J, Ladinig A, Al Dissi A, MacPhee D, Detmer S. Relationships of CD163 and CD169 positive cell numbers in the endometrium and fetal placenta with type 2 PRRSV RNA concentration in fetal thymus. Vet Res. 2016;47:76 pubmed publisher
    ..The objectives of this study were to investigate associations between numbers of CD163 and CD169 positive macrophages, cathepsin positive areolae, and type 2 PRRSV load at the maternal-fetal interface in order ..
  45. Lin X, Gu Y, Kapoor A, Wei F, Aziz T, Ojo D, et al. Overexpression of MUC1 and Genomic Alterations in Its Network Associate with Prostate Cancer Progression. Neoplasia. 2017;19:857-867 pubmed publisher
    ..0458) and DFS (P=.0163) in melanoma patients (n=367). MUC1 upregulation is associated with CRPC and bone metastasis. A nine-gene signature derived from a MUC1 network predicts PC recurrence. ..
  46. Mikkelsen H, Huizinga J, Larsen J, Kirkeby S. Ionized calcium-binding adaptor molecule 1 positive macrophages and HO-1 up-regulation in intestinal muscularis resident macrophages. Anat Rec (Hoboken). 2017;300:1114-1122 pubmed publisher
    ..Mice were injected with LPS or saline and sacrificed after 6 hr. Whole mounts were stained with antibodies toward CD169, ionized calcium-binding adaptor molecule 1 (iba1) (microglial/macrophage marker) and heme oxygenase-1 (HO-1)...
  47. Byrareddy S, Little D, Mayne A, Villinger F, Ansari A. Phenotypic and Functional Characterization of Monoclonal Antibodies with Specificity for Rhesus Macaque CD200, CD200R and Mincle. PLoS ONE. 2015;10:e0140689 pubmed publisher
    ..We conclude that these mAbs may have potential to be used as adjunctive therapeutic agents to control/inhibit SIV/HIV infection. ..
  48. Zhang R, Zhu X. [Relationship between macrophages and erythropoiesis]. Zhongguo Dang Dai Er Ke Za Zhi. 2016;18:94-9 pubmed
    ..A recent mouse study has demonstrated that the phenotype of macrophages in erythroblastic islands is CD169+ VCAM-1+ ER-HR3+ CD11b+ F4/80+ Ly-6G+...
  49. Le Gars M, Haustant M, Klezovich Bénard M, Paget C, Trottein F, Goossens P, et al. Mechanisms of Invariant NKT Cell Activity in Restraining Bacillus anthracis Systemic Dissemination. J Immunol. 2016;197:3225-3232 pubmed
    ..anthracis systemic dissemination and prolonged mouse survival. Depletion of subcapsular sinus CD169-positive macrophages by clodronate-containing liposome was associated with a lack of iNKT cell activation in the ..
  50. Gupta P, Lai S, Sheng J, Tetlak P, Balachander A, Claser C, et al. Tissue-Resident CD169(+) Macrophages Form a Crucial Front Line against Plasmodium Infection. Cell Rep. 2016;16:1749-1761 pubmed publisher
    ..Here, we show that in the absence of tissue-resident CD169(+) macrophages, Plasmodium berghei ANKA (PbA) infection results in significantly increased parasite sequestration, ..
  51. Zhang L, Cui Z, Zhou L, Kang Y, Li L, Li J, et al. Developing a Triple Transgenic Cell Line for High-Efficiency Porcine Reproductive and Respiratory Syndrome Virus Infection. PLoS ONE. 2016;11:e0154238 pubmed publisher
    ..several groups have attempted to construct different transgenic cell lines with three PRRSV receptors: CD163, CD169, and CD151...
  52. Neidleman J, Chen J, Kohgadai N, Müller J, Laustsen A, Thavachelvam K, et al. Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells. PLoS Pathog. 2017;13:e1006163 pubmed publisher
    ..Inhibiting fibroblast-mediated enhancement of HIV infection should be considered as a novel prevention strategy. ..
  53. Prather R, Whitworth K, Schommer S, Wells K. Genetic engineering alveolar macrophages for host resistance to PRRSV. Vet Microbiol. 2017;209:124-129 pubmed publisher
    ..One popular model had PRRSV first interacting with heparin sulfate followed by binding to sialoadhesin and then being internalized into an endosome...
  54. Groh J, Ribechini E, Stadler D, Schilling T, Lutz M, Martini R. Sialoadhesin promotes neuroinflammation-related disease progression in two mouse models of CLN disease. Glia. 2016;64:792-809 pubmed publisher
    ..We now investigated the role of the inflammation-related cell adhesion molecule sialoadhesin (Sn) in Ppt1(-/-) and Cln3(-/-) mice, a model of the most frequent form, CLN3 disease...
  55. Xiong Y, Zhou Y, Rong G, Wu W, Liang Y, Yang Z, et al. Siglec-1 on monocytes is a potential risk marker for monitoring disease severity in coronary artery disease. Clin Biochem. 2009;42:1057-63 pubmed publisher
    ..316, P=0.016) and homocysteine level (r=0.224, P=0.042). Siglec-1 may be considered as a potential non-invasive indicator for monitoring disease severity and a biomarker for predicting the relative risk of cardiovascular events. ..
  56. Pino M, Erkizia I, Benet S, Erikson E, Fernández Figueras M, Guerrero D, et al. HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells. Retrovirology. 2015;12:37 pubmed publisher
    ..The receptor Siglec-1 (CD169) potently enhances HIV-1 trans-infection and is regulated by immune activating signals present throughout the ..
  57. Souza de Lima D, Nunes V, Ogusku M, Sadahiro A, Pontillo A, Alencar B. Polymorphisms in SIGLEC1 contribute to susceptibility to pulmonary active tuberculosis possibly through the modulation of IL-1ß. Infect Genet Evol. 2017;55:313-317 pubmed publisher
    Siglec-1/CD169 is a sialoadhesin expressed by macrophages thought to function in cell-to-cell interactions...
  58. Zhang Y, Li J, Jiang Z, Li L, Wu Y, Zheng L. CD169 identifies an anti-tumour macrophage subpopulation in human hepatocellular carcinoma. J Pathol. 2016;239:231-41 pubmed publisher
    ..In the present study, a population of CD169(+) macrophages with relatively high expression levels of HLA-DR and CD86 was identified in human hepatocellular ..
  59. Fernández Caballero T, Alvarez B, Revilla C, Zaldivar Lopez S, Alonso F, Garrido J, et al. Phenotypic and functional characterization of porcine bone marrow monocyte subsets. Dev Comp Immunol. 2018;81:95-104 pubmed publisher
    ..Whether these subsets represent different developmental stages, and how are they related remain to be investigated. ..
  60. Shiota T, Miyasato Y, Ohnishi K, Yamamoto Ibusuki M, Yamamoto Y, Iwase H, et al. The Clinical Significance of CD169-Positive Lymph Node Macrophage in Patients with Breast Cancer. PLoS ONE. 2016;11:e0166680 pubmed publisher
    ..In this study, the prognostic significance of CD169+ LN macrophages was examined in patients with breast cancer...
  61. Garba A, Desmarets L, Acar D, Devriendt B, Nauwynck H. Immortalized porcine mesenchymal cells derived from nasal mucosa, lungs, lymph nodes, spleen and bone marrow retain their stemness properties and trigger the expression of siglec-1 in co-cultured blood monocytic cells. PLoS ONE. 2017;12:e0186343 pubmed publisher
    ..Mesenchymal cells isolated from nasal mucosa, lungs, spleen, lymph nodes and bone marrow were successfully immortalized and these cell lines retained their stemness properties and displayed immunomodulatory effects on blood monocytes...
  62. Xiong Y, Cheng Y, Lin Q, Wu A, Yu J, Li C, et al. Increased expression of Siglec-1 on peripheral blood monocytes and its role in mononuclear cell reactivity to autoantigen in rheumatoid arthritis. Rheumatology (Oxford). 2014;53:250-9 pubmed publisher
    ..Elevated Siglec-1 expression in PBMCs and monocytes can potentially serve as a biomarker for monitoring disease activity in RA. Siglec-1 may also play a proinflammatory role in stimulating lymphocyte proliferation and activation in RA. ..
  63. Eakin A, Bustard M, McGeough C, Ahmed T, Bjourson A, Gibson D. Siglec-1 and -2 as potential biomarkers in autoimmune disease. Proteomics Clin Appl. 2016;10:635-44 pubmed publisher
    ..Fluctuations in these glycosylation-dependent pathways could act as sentinels of disease activity or drug responses. If validated, protein modification and cellular response markers could help clinicians achieve remission earlier. ..
  64. Ashokkumar C, Gabriellan A, Ningappa M, Mazariegos G, Sun Q, Sindhi R. Increased monocyte expression of sialoadhesin during acute cellular rejection and other enteritides after intestine transplantation in children. Transplantation. 2012;93:561-4 pubmed publisher
    b>Sialoadhesin (CD169) facilitates T-cell priming when overexpressed on inflammatory monocytes. Monocyte-derived macrophages prime acute cellular rejection after intestine transplantation (ITx)...
  65. Kawasaki N, VELA J, Nycholat C, Rademacher C, Khurana A, Van Rooijen N, et al. Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation. Proc Natl Acad Sci U S A. 2013;110:7826-31 pubmed publisher
    ..CD169 is known as sialoadhesin (Sn), a macrophage-specific adhesion and endocytic receptor of the siglec family that recognizes sialic acid ..
  66. Yanagihashi Y, Segawa K, Maeda R, Nabeshima Y, Nagata S. Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis. Proc Natl Acad Sci U S A. 2017;114:8800-8805 pubmed publisher
    ..Resident peritoneal macrophages, Kupffer cells, and CD169+ skin macrophages required Tim4 for TAM-stimulated efferocytosis, whereas efferocytosis by ..
  67. Shinde P, Xu H, Maney S, Kloetgen A, Namineni S, Zhuang Y, et al. Tumor Necrosis Factor-Mediated Survival of CD169+ Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection. J Virol. 2018;92: pubmed publisher
    ..Although a crucial role of CD169+ cells during vesicular stomatitis virus (VSV) infections is increasingly recognized, factors ..
  68. Kijewski S, Akiyama H, Feizpour A, Miller C, Ramirez N, Reinhard B, et al. Access of HIV-2 to CD169-dependent dendritic cell-mediated trans infection pathway is attenuated. Virology. 2016;497:328-336 pubmed publisher
    ..We hypothesized that reduced interaction of HIV-2 with CD169, the primary HIV-1 attachment factor on monocyte-derived dendritic cells (DCs) that targets captured virus ..
  69. Akiyama H, Ramirez N, Gibson G, Kline C, Watkins S, Ambrose Z, et al. Interferon-Inducible CD169/Siglec1 Attenuates Anti-HIV-1 Effects of Alpha Interferon. J Virol. 2017;91: pubmed publisher
    ..We have recently identified a type I IFN-inducible protein, CD169, as the HIV-1 attachment factor on dendritic cells (DCs) that can mediate robust infection of CD4+ T ..
  70. Izquierdo Useros N, Lorizate M, McLaren P, Telenti A, Kräusslich H, Martinez Picado J. HIV-1 capture and transmission by dendritic cells: the role of viral glycolipids and the cellular receptor Siglec-1. PLoS Pathog. 2014;10:e1004146 pubmed publisher
    ..In contrast, DC-SIGN, long considered to be the main receptor for DC capture of HIV-1, plays a minor role in mature DC-mediated HIV-1 capture and trans-infection. ..
  71. De Saint Jean A, Lucht F, Bourlet T, Delézay O. Transforming growth factor beta 1 up-regulates CD169 (sialoadhesin) expression on monocyte-derived dendritic cells: role in HIV sexual transmission. AIDS. 2014;28:2375-80 pubmed publisher
    Recent data describe CD169 (also called sialoadhesin or Siglec-1) as the main HIV-1 receptor expressed by mucosal dendritic cells involved in the capture of the virus and its transmission to target cells...
  72. Oh D, Oh J, Jung H, Lee H. Transient Depletion of CD169+ Cells Contributes to Impaired Early Protection and Effector CD8+ T Cell Recruitment against Mucosal Respiratory Syncytial Virus Infection. Front Immunol. 2017;8:819 pubmed publisher
    ..Alveolar macrophages (AMs) play a crucial role in combatting airborne pathogens, strongly express CD169, and are localized in the lung alveoli...
  73. Sedwick C. How HIV sneaks aboard mature dendritic cells. PLoS Biol. 2012;10:e1001454 pubmed publisher
  74. Akiyama H, Ramirez N, Gudheti M, Gummuluru S. CD169-mediated trafficking of HIV to plasma membrane invaginations in dendritic cells attenuates efficacy of anti-gp120 broadly neutralizing antibodies. PLoS Pathog. 2015;11:e1004751 pubmed publisher
    Myeloid dendritic cells (DCs) can capture HIV-1 via the receptor CD169/Siglec-1 that binds to the ganglioside, GM3, in the virus particle membrane...
  75. Komohara Y, Ohnishi K, Takeya M. Possible functions of CD169-positive sinus macrophages in lymph nodes in anti-tumor immune responses. Cancer Sci. 2017;108:290-295 pubmed publisher
    ..In colorectal tumor, malignant melanoma, and endometrial tumor, it was shown that a high density of CD169-positive macrophages in the LN sinus was a predictive factor for better clinical prognosis...
  76. Hammonds J, Beeman N, Ding L, Takushi S, Francis A, Wang J, et al. Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1. PLoS Pathog. 2017;13:e1006181 pubmed publisher
    ..Inhibiting or eliminating the VCC may be an important component of strategies to reduce HIV transmission and to eradicate HIV reservoirs. ..
  77. Seyerl M, Kirchberger S, Majdic O, Seipelt J, Jindra C, Schrauf C, et al. Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. Eur J Immunol. 2010;40:321-9 pubmed publisher
    ..The induction of IL-35-producing T cells by R-DC was FOXP3-independent, but blocking of B7-H1 (CD274) and sialoadhesin (CD169) on R-DC with mAb against both receptors prevented the induction of IL-35...
  78. Zamze S, Harvey D, Pesheva P, Mattu T, Schachner M, Dwek R, et al. Glycosylation of a CNS-specific extracellular matrix glycoprotein, tenascin-R, is dominated by O-linked sialylated glycans and "brain-type" neutral N-glycans. Glycobiology. 1999;9:823-31 pubmed
    ..The possibility that these O -glycans enable tenascin-R to interact in the CNS either with the myelin associated glycoprotein or with sialoadhesin on activated microglia is discussed.
  79. Black L, Saunderson S, Coutinho F, Muhsin Sharafaldine M, Damani T, Dunn A, et al. The CD169 sialoadhesin molecule mediates cytotoxic T-cell responses to tumour apoptotic vesicles. Immunol Cell Biol. 2016;94:430-8 pubmed publisher
    ..Extracellular vesicles express membrane-bound sialic acids, which enable their capture by CD169 (sialoadhesin; Siglec-1) expressing macrophages in the lymph node and spleen...
  80. Fraschilla I, Pillai S. Viewing Siglecs through the lens of tumor immunology. Immunol Rev. 2017;276:178-191 pubmed publisher
    ..b>CD169 is a Siglec that may function as an adhesion molecule and a facilitator of the recognition and internalization of ..
  81. French B, Sendil S, Pierson R, Azimzadeh A. The role of sialic acids in the immune recognition of xenografts. Xenotransplantation. 2017;: pubmed publisher
    ..a central role in inflammation by influencing binding of the asialoglycoprotein receptor 1 (ASGR-1), Siglec-1 (Sialoadhesin), and cellular interactions mediated by the selectin, integrin, and galectin receptor families...
  82. Mucklow S, Hartnell A, Mattei M, Gordon S, Crocker P. Sialoadhesin (Sn) maps to mouse chromosome 2 and human chromosome 20 and is not linked to the other members of the sialoadhesin family, CD22, MAG, and CD33. Genomics. 1995;28:344-6 pubmed
    b>Sialoadhesin is a cell-cell interaction molecule expressed by subpopulations of tissue macrophages. It contains 17 immunoglobulin (Ig)-like domains and is structurally related to CD22, MAG, and CD33...
  83. Yu X, Feizpour A, Ramirez N, Wu L, Akiyama H, Xu F, et al. Glycosphingolipid-functionalized nanoparticles recapitulate CD169-dependent HIV-1 uptake and trafficking in dendritic cells. Nat Commun. 2014;5:4136 pubmed publisher
    ..of human immunodeficiency virus-1 (HIV-1) viral particles, mediates interactions between HIV-1 and Siglec1/CD169, a protein expressed on dendritic cells (DCs)...
  84. De Schryver M, Cappoen D, Elewaut D, Nauwynck H, Maes L, Caljon G, et al. Monoclonal antibody binding to the macrophage-specific receptor sialoadhesin alters the phagocytic properties of human and mouse macrophages. Cell Immunol. 2017;312:51-60 pubmed publisher
    b>Sialoadhesin (Sn) is a surface receptor expressed on macrophages in steady state conditions, but during inflammation, Sn can be upregulated both on macrophages and on circulating monocytes...
  85. Seu K, Papoin J, Fessler R, Hom J, Huang G, Mohandas N, et al. Unraveling Macrophage Heterogeneity in Erythroblastic Islands. Front Immunol. 2017;8:1140 pubmed publisher
    ..these approaches based on the expectation that EBI macrophages are a homogeneous population (F4/80+/CD169+/VCAM-1+ for example) provide an incomplete picture and potentially overlook critical ..
  86. Xiao H, Woods E, Vukojicic P, Bertozzi C. Precision glycocalyx editing as a strategy for cancer immunotherapy. Proc Natl Acad Sci U S A. 2016;113:10304-9 pubmed publisher
    ..Precision glycocalyx editing with antibody-enzyme conjugates is therefore a promising avenue for cancer immune therapy. ..
  87. Strömvall K, Sundkvist K, Ljungberg B, Halin Bergström S, Bergh A. Reduced number of CD169+ macrophages in pre-metastatic regional lymph nodes is associated with subsequent metastatic disease in an animal model and with poor outcome in prostate cancer patients. Prostate. 2017;77:1468-1477 pubmed publisher
    Tumor-derived antigens are captured by CD169+ (SIGLEC1+ ) sinus macrophages in regional lymph nodes (LNs), and are presented to effector cells inducing an anti-tumor immune response...
  88. Gummuluru S, Pina Ramirez N, Akiyama H. CD169-dependent cell-associated HIV-1 transmission: a driver of virus dissemination. J Infect Dis. 2014;210 Suppl 3:S641-7 pubmed publisher
    ..We will evaluate the role of CD169 as a DC-associated HIV-1 attachment factor, investigate the molecular mechanisms by which HIV-1 particles are ..
  89. Iftakhar E Khuda I, Fair Mäkelä R, Kukkonen Macchi A, Elima K, Karikoski M, Rantakari P, et al. Gene-expression profiling of different arms of lymphatic vasculature identifies candidates for manipulation of cell traffic. Proc Natl Acad Sci U S A. 2016;113:10643-8 pubmed publisher
    ..Further characterizations of Siglec-1 (CD169) and macrophage scavenger receptor 1 (MSR1/CD204), show that they are discriminatively expressed on lymphatic ..
  90. Lisney A, Szelinski F, Reiter K, Burmester G, Rose T, Dorner T. High maternal expression of SIGLEC1 on monocytes as a surrogate marker of a type I interferon signature is a risk factor for the development of autoimmune congenital heart block. Ann Rheum Dis. 2017;76:1476-1480 pubmed publisher
    ..High expression of SIGLEC1 in pregnant women with autoantibodies against Ro/SS-A indicates an enhanced risk for CHB development, and these women may benefit especially from IFN-? directed therapy, for example with hydroxychloroquine. ..
  91. Perez O, Yeung S, Vera Licona P, Romagnoli P, Samji T, Ural B, et al. CD169+ macrophages orchestrate innate immune responses by regulating bacterial localization in the spleen. Sci Immunol. 2017;2: pubmed publisher
    ..We show that the strategic position of splenic marginal zone CD169+ macrophages is vital for rapid initiation of antibacterial responses...
  92. Jobe O, Trinh H, Kim J, AlSalmi W, Tovanabutra S, Ehrenberg P, et al. Effect of cytokines on Siglec-1 and HIV-1 entry in monocyte-derived macrophages: the importance of HIV-1 envelope V1V2 region. J Leukoc Biol. 2016;99:1089-106 pubmed publisher