Gene Symbol: SHMT1
Description: serine hydroxymethyltransferase 1
Alias: CSHMT, SHMT, serine hydroxymethyltransferase, cytosolic, cytoplasmic serine hydroxymethyltransferase, glycine hydroxymethyltransferase, serine hydroxymethyltransferase 1 (soluble), serine methylase
Species: human
Products:     SHMT1

Top Publications

  1. Geisel J, Hübner U, Bodis M, Schorr H, Knapp J, Obeid R, et al. The role of genetic factors in the development of hyperhomocysteinemia. Clin Chem Lab Med. 2003;41:1427-34 pubmed five genes (5,10-methylenetetrahydrofolate reductase (MTHFR) 677C --> T, serine hydroxymethyltransferase (SHMT) 1420C --> T, thymidylate synthase (TS) 2R --> 3R, catechol-O-methyltransferase (COMT) 1947G --> A and ..
  2. Perry C, Yu S, Chen J, Matharu K, Stover P. Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cells. Arch Biochem Biophys. 2007;462:21-7 pubmed
    ..serine through the activity of the pyridoxal-phosphate (PLP)-dependent isozymes of serine hydroxymethyltransferase (SHMT)...
  3. Steck S, Keku T, Butler L, Galanko J, Massa B, Millikan R, et al. Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk. J Nutrigenet Nutrigenomics. 2008;1:196-204 pubmed publisher
    ..Five SNPs were genotyped using DNA from whole blood: SHMT C1420T; MTRR A66G; MTR A2756G, and the previously-reported MTHFR C677T and MTHFR A1298C...
  4. Girgis S, Nasrallah I, Suh J, Oppenheim E, Zanetti K, Mastri M, et al. Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyltransferase gene. Gene. 1998;210:315-24 pubmed
    The human cytoplasmic serine hydroxymethyltransferase (CSHMT) gene was isolated, sequenced and its expression characterized in human MCF-7 mammary carcinoma and SH_5Y5Y neuroblastoma cells...
  5. Herbig K, Chiang E, Lee L, Hills J, Shane B, Stover P. Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses. J Biol Chem. 2002;277:38381-9 pubmed
    ..The influence of cytoplasmic serine hydroxymethyltransferase (cSHMT) on this competition was examined in MCF-7 cells...
  6. van den Donk M, Visker M, Harryvan J, Kok F, Kampman E. Dietary intake of B-vitamins, polymorphisms in thymidylate synthase and serine hydroxymethyltransferase 1, and colorectal adenoma risk: a Dutch case-control study. Cancer Lett. 2007;250:146-53 pubmed
    ..768 cases and 709 controls, we investigated the associations between colorectal adenomas and TS tandem repeat and SHMT1 C1420T polymorphisms, and the interplay with B-vitamins...
  7. Wang Y, Guo W, He Y, Chen Z, Wen D, Zhang X, et al. Association of MTHFR C677T and SHMT(1) C1420T with susceptibility to ESCC and GCA in a high incident region of Northern China. Cancer Causes Control. 2007;18:143-52 pubmed
    ..folate reductase gene (MTHFR C677T) and the C to T transition in the serine hydroxymethyltransferase ( 1 )gene (SHMT ( 1 ) C1420T) and the increased risk of carcinogenesis of esophageal squamous cell carcinoma (ESCC) and gastric ..
  8. Woeller C, Anderson D, Szebenyi D, Stover P. Evidence for small ubiquitin-like modifier-dependent nuclear import of the thymidylate biosynthesis pathway. J Biol Chem. 2007;282:17623-31 pubmed
    ..In this study, the mechanism for the preferential partitioning of cytoplasmic serine hydroxymethyltransferase (cSHMT)-derived methylenetetrahydrofolate to de novo thymidylate biosynthesis was investigated...
  9. Guerreiro C, Carmona B, Goncalves S, Carolino E, Fidalgo P, Brito M, et al. Risk of colorectal cancer associated with the C677T polymorphism in 5,10-methylenetetrahydrofolate reductase in Portuguese patients depends on the intake of methyl-donor nutrients. Am J Clin Nutr. 2008;88:1413-8 pubmed
    ..polymorphisms [C677T MTHFR (methylene tetrahydrofolate reductase), A2756G MTR (methionine synthase), and C1420T SHMT (serine hydroxymethyltransferase)] with the intake of methyl-donor nutrients in CRC risk...

More Information

Publications114 found, 100 shown here

  1. Anderson D, Stover P. SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis. PLoS ONE. 2009;4:e5839 pubmed publisher
    The three enzymes that constitute the de novo thymidylate synthesis pathway in mammals, cytoplasmic serine hydroxymethyltransferase (SHMT1), thymidylate synthase (TYMS) and dihydrofolate reductase (DHFR) undergo sumoylation and nuclear ..
  2. Collin S, Metcalfe C, Zuccolo L, Lewis S, Chen L, Cox A, et al. Association of folate-pathway gene polymorphisms with the risk of prostate cancer: a population-based nested case-control study, systematic review, and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2009;18:2528-39 pubmed publisher
    ..6 studies; 7,493 cases; 36,941 controls), SLC19A1/RFC1 G80A (rs1051266; 4 studies; 6,222 cases; 35,821 controls), SHMT1 C1420T (rs1979277; 2 studies; 2,689 cases; 4,110 controls), and FOLH1 T1561C (rs202676; 5 studies; 6,314 cases; 35,..
  3. Vijayakrishnan J, Houlston R. Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: a systematic review and meta-analysis. Haematologica. 2010;95:1405-14 pubmed publisher
    ..16; 95%ci: 1.04-1.30), mtrr a66g (or=0.73, 95%ci:0.59-0.91), shmt1 c1420t (or=0.79, 95%ci: 0.65-0.98), rfc1 g80a (or=1.37, 95%ci: 1.11-1.69), cyp1a1*2a (or=1.36, 95%ci:1.11-1...
  4. Weiner A, Beresina O, Voronina E, Voropaeva E, Boyarskih U, Pospelova T, et al. Polymorphisms in folate-metabolizing genes and risk of non-Hodgkin's lymphoma. Leuk Res. 2011;35:508-15 pubmed publisher
    ..role of single nucleotide polymorphisms (SNPs) in the folate-metabolizing genes MTHFR, MTR, MTRR, MTHFD, CBS and SHMT in regulating genetic susceptibility to Non-Hodgkin's lymphoma (NHL)...
  5. di Salvo M, Contestabile R, Paiardini A, Maras B. Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: the heme connection. Med Hypotheses. 2013;80:633-6 pubmed publisher
  6. Garrow T, Brenner A, Whitehead V, Chen X, Duncan R, Korenberg J, et al. Cloning of human cDNAs encoding mitochondrial and cytosolic serine hydroxymethyltransferases and chromosomal localization. J Biol Chem. 1993;268:11910-6 pubmed
    Human cDNAs for cytosolic and mitochondrial serine hydroxymethyltransferase (SHMT) were cloned by functional complementation of an Escherichia coli glyA mutant with a human cDNA library...
  7. Fu T, Rife J, Schirch V. The role of serine hydroxymethyltransferase isozymes in one-carbon metabolism in MCF-7 cells as determined by (13)C NMR. Arch Biochem Biophys. 2001;393:42-50 pubmed
    ..2-(13)C]Glycine is not a donor of one-carbons groups, confirming that MCF-7 cells lack a functional glycine cleavage system. ..
  8. Hishida A, Matsuo K, Hamajima N, Ito H, Ogura M, Kagami Y, et al. Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma. Haematologica. 2003;88:159-66 pubmed
    ..synthase (TS) 28-bp tandem repeats in the promoter region and in cytosolic serine hydroxymethyltransferase (SHMT1 C1420T) have been reported to modulate the risk of adult acute lymphocytic leukemia (ALL)...
  9. Chen J, Kyte C, Valcin M, Chan W, Wetmur J, Selhub J, et al. Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study. Int J Cancer. 2004;110:617-20 pubmed
    ..Cytosolic serine hydroxymethyltransferase (cSHMT), methylenetetrahydrofolate dehydrogenase (MTHFD1) and glutamate carboxypeptidase II (GCPII) are key genes ..
  10. Komlósi V, Hitre E, Pap E, Adleff V, Réti A, Székely E, et al. SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer. BMC Cancer. 2010;10:525 pubmed publisher
    Association between rectal or colon cancer risk and serine hydroxymethyltransferase 1 (SHMT1) C1420T or methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms was assessed...
  11. Lee K, Lan Q, Kricker A, Purdue M, Grulich A, Vajdic C, et al. One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia. Hum Genet. 2007;122:525-33 pubmed
    ..were genotyped for 14 selected single-nucleotide polymorphisms in 10 genes (CBS, FPGS, FTHFD, MTHFR, MTHFS, MTR, SHMT1, SLC19A1, TCN1, and TYMS)...
  12. Martiniova L, Field M, Finkelstein J, Perry C, Stover P. Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects. Am J Clin Nutr. 2015;101:860-9 pubmed publisher
    ..Serine hydroxymethyltransferase 1 (SHMT1) is an essential scaffold protein in folate-dependent de novo thymidylate synthesis in the nucleus...
  13. Milano T, di Salvo M, Angelaccio S, Pascarella S. Conserved water molecules in bacterial serine hydroxymethyltransferases. Protein Eng Des Sel. 2015;28:415-26 pubmed publisher
    ..This work provides a map of the conserved water molecules helpful for deciphering SHMT mechanism and for rational design of molecular engineering experiments.
  14. Roy G, Ouellette M. Inactivation of the cytosolic and mitochondrial serine hydroxymethyl transferase genes in Leishmania major. Mol Biochem Parasitol. 2015;204:106-110 pubmed publisher
    ..By gene inactivation we succeeded in generating three cells lines one without the cytosolic cSHMT, one without the mitochondrial mSHMT, and finally one L. major line without any SHMT...
  15. Piao W, Guo J, Bao Y, Wang F, Zhang T, Huo J, et al. Analysis of polymorphisms of genes associated with folate-mediated one-carbon metabolism and neural tube defects in Chinese Han Population. Birth Defects Res A Clin Mol Teratol. 2016;106:232-9 pubmed publisher
    ..aimed to investigate the single nucleotide polymorphisms (SNPs) of the genes BHMT, CUBN, FTCD, GAMT, GART, SARDH, SHMT1, and MUT, and their effect on NTDs in the Chinese Han population...
  16. Naushad S, Hussain T, Indumathi B, Samreen K, Alrokayan S, Kutala V. Machine learning algorithm-based risk prediction model of coronary artery disease. Mol Biol Rep. 2018;: pubmed publisher
    ..5%). This model depicted hypertension and alcohol intake as the key predictors of CAD risk followed by cSHMT C1420T, GCPII C1561T, diabetes, GSTT1, CYP1A1 m2, TYMs 5'-UTR 28 bp tandem repeat and MTRR A66G...
  17. Nandi P, Ghosh S, Jana K, Sen P. Elucidation of the involvement of p14, a sperm protein during maturation, capacitation and acrosome reaction of caprine spermatozoa. PLoS ONE. 2012;7:e30552 pubmed publisher
    ..All these results taken together clearly indicate that p14 is intimately involved and plays a critical role in the acrosomal membrane fusion event. ..
  18. Zhang M, Wu W, Chen Z. Structure and function of cytoplasmic serine hydroxymethyltransferase from Pichia pastoris. Biochem Biophys Res Commun. 2018;496:753-757 pubmed publisher
    Serine hydroxymethyltransferase (SHMT) catalyzes the interconversion of serine and glycine, which is crucial for one carbon metabolism...
  19. Moore L, Malats N, Rothman N, Real F, Kogevinas M, Karami S, et al. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer. Int J Cancer. 2007;120:2452-8 pubmed
    ..between bladder cancer risk and 33 single nucleotide polymorphisms (SNPs) in 8 genes (CBS, CTH, MTHFR, MTR, MTRR, SHMT1, SLC19A1 and TYMS) and interactions with dietary variables involved in this pathway...
  20. Baccarelli A, Cassano P, Litonjua A, Park S, Suh H, Sparrow D, et al. Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms. Circulation. 2008;117:1802-9 pubmed publisher
    ..and related gene polymorphisms (C677T methylenetetrahydrofolate reductase [MTHFR] and C1420T cytoplasmic serine hydroxymethyltransferase [cSHMT])...
  21. Safari E, Hassan Z, Moazzeni S. Shark cartilage 14 kDa protein as a dendritic cells activator. Immunopharmacol Immunotoxicol. 2015;37:165-70 pubmed publisher
    ..However, further studies are required to examine this proposal. ..
  22. Hulse J, Ellis S, Henderson L. Carnitine biosynthesis. beta-Hydroxylation of trimethyllysine by an alpha-ketoglutarate-dependent mitochondrial dioxygenase. J Biol Chem. 1978;253:1654-9 pubmed
    ..1.2.1) to yield gamma-butyrobetaine aldehyde and glycine. Conversion of about 40% of the epsilon-N-trimethyl-L-lysine to beta-hydroxy-epsilon-N-trimethyl-L-lysine was accomplished by this system with little or no further metabolism. ..
  23. Bentley A, Raiszadeh F, Stover P, Hunter D, Hankinson S, Cassano P. No association between cSHMT genotypes and the risk of breast cancer in the Nurses' Health Study. Eur J Clin Nutr. 2010;64:108-10 pubmed publisher
    ..b>Cytoplasmic serine hydroxymethyltransferase (cSHMT) affects the flow of one-carbon units through the folate metabolic network, but there is ..
  24. Kandoth P, Liu S, Prenger E, Ludwig A, Lakhssassi N, Heinz R, et al. Systematic Mutagenesis of Serine Hydroxymethyltransferase Reveals an Essential Role in Nematode Resistance. Plant Physiol. 2017;175:1370-1380 pubmed publisher
    ..Mapping of the identified mutations onto the SHMT structural model uncovered key residues for structural stability, ligand binding, enzyme activity, and protein ..
  25. Kumudini N, Naushad S, Alex Stanley B, Niveditha M, Sharmila G, Kumaraswami K, et al. Comparative analysis of four disease prediction models of Parkinson's disease. Mol Cell Biochem. 2016;411:127-34 pubmed publisher
    ..The RP model showed SHMT C1420T as important determinant of PD risk...
  26. Giusti B, Sestini I, Saracini C, Sticchi E, Bolli P, Magi A, et al. High-throughput multiplex single-nucleotide polymorphism (SNP) analysis in genes involved in methionine metabolism. Biochem Genet. 2008;46:406-23 pubmed publisher the candidate genes AHCY, BHMT, BHMT2, CBS, ENOSF1, FOLH1, MTHFD1, MTHFR, MTR, MTRR, NNMT, PON1, PON2, SLC19A1, SHMT1, TCN2, and TYMS. We were able to analyze 57 of the SNPs (79%)...
  27. Naushad S, Rama Devi A, Nivetha S, Lakshmitha G, Stanley A, Hussain T, et al. Neuro-fuzzy model of homocysteine metabolism. J Genet. 2017;96:919-926 pubmed be positively associatiated with homocysteine, while nonvegetarian diet, serine hydroxymethyltransferase 1 (SHMT1) C1420T and TYMS 5'-UTR 28 bp tandem repeat exhibited negative association with homocysteine...
  28. Succi M, de Castro T, Galbiatti A, Arantes L, da Silva J, Maniglia J, et al. DNMT3B C46359T and SHMT1 C1420T polymorphisms in the folate pathway in carcinogenesis of head and neck. Mol Biol Rep. 2014;41:581-9 pubmed publisher
    ..We investigated DNMT3B C46359T (rs2424913) and SHMT1 C1420T (rs1979277) polymorphisms related to folate pathway in head and neck cancer (HNC) risk and the association ..
  29. Kumar M, Kong K, Javier R. Hijacking Dlg1 for oncogenic phosphatidylinositol 3-kinase activation in human epithelial cells is a conserved mechanism of human adenovirus E4-ORF1 proteins. J Virol. 2014;88:14268-77 pubmed publisher
    ..Our findings further suggest that the conserved mechanism revealed here may be targeted for development of therapeutic drugs to treat and prevent adenovirus-associated human diseases. ..
  30. Verma A, Bule P, Ribeiro T, Brás J, Mukherjee J, Gupta M, et al. The family 6 Carbohydrate Binding Module (CtCBM6) of glucuronoxylanase (CtXynGH30) of Clostridium thermocellum binds decorated and undecorated xylans through cleft A. Arch Biochem Biophys. 2015;575:8-21 pubmed publisher
    ..The results suggest that CtCBM6 interacts with carbohydrates through cleft A, which recognizes equally well both decorated and un-decorated xylans. ..
  31. Marucci G, Zampieri B, Biselli J, Valentin S, Bertollo E, Eberlin M, et al. Polymorphism C1420T of Serine hydroxymethyltransferase gene on maternal risk for Down syndrome. Mol Biol Rep. 2012;39:2561-6 pubmed publisher
    ..In this study, we analyzed the influence of the polymorphism C1420T in Serine hydroxymethyltransferase (SHMT) gene on maternal risk for DS and on metabolites concentrations of the folate pathway (serum folate and plasma ..
  32. Yuan C, Wang Y, Zhao H, Zhang L, Wang Y, Liu X, et al. Genetic diversity of rhg1 and Rhg4 loci in wild soybeans resistant to soybean cyst nematode race 3. Genet Mol Res. 2016;15: pubmed publisher
    ..soja accessions that are resistant to SCN race 3 for polymorphisms in the resistance genes, rhg1, Rhg4, and SHMT, and investigated their genetic relationship with eight Glycine max resistant cultivars...
  33. Tramonti A, Paiardini A, Paone A, Bouzidi A, Giardina G, Guiducci G, et al. Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes. Arch Biochem Biophys. 2018;653:71-79 pubmed publisher
    ..It exists in cytosolic (SHMT1) and mitochondrial (SHMT2) isoforms...
  34. Núñez Díaz J, Fumanal M, do Vale A, Fernández Díaz C, Moriñigo M, Balebona M. Transcription of IVIAT and Virulence Genes in Photobacterium damselae Subsp. piscicida Infecting Solea senegalensis. Microorganisms. 2018;6: pubmed publisher
    ..HutB and HutD), oxidative stress defence (AhpC and Sod), adhesion (PDP_0080), toxins (AIP56) and metabolism (Impdh, Shmt and AlaRS) were detected in Phdp infecting S. senegalensis head kidney or liver...
  35. Jansen van Vuren P, Wiley M, Palacios G, Storm N, McCulloch S, Markotter W, et al. Isolation of a Novel Fusogenic Orthoreovirus from Eucampsipoda africana Bat Flies in South Africa. Viruses. 2016;8:65 pubmed publisher
    ..This is the first report on isolation of an orthoreovirus from an arthropod host associated with bats, and phylogenetic and sequence data suggests that MAHLV constitutes a new species within the Orthoreovirus genus. ..
  36. Fox J, Stover P. Mechanism of the internal ribosome entry site-mediated translation of serine hydroxymethyltransferase 1. J Biol Chem. 2009;284:31085-96 pubmed publisher
    The 5'-untranslated region (UTR) of serine hydroxymethyltransferase 1 (SHMT1) contains an internal ribosome entry site (IRES) that regulates SHMT1 expression, a rate-limiting enzyme in de novo thymidylate biosynthesis...
  37. Lim U, Wang S, Hartge P, Cozen W, Kelemen L, Chanock S, et al. Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER case-control study. Blood. 2007;109:3050-9 pubmed
    ..risk of NHL over-all with BHMTEx8+453A>T and increased risk with CBS Ex13+41C>T, FPGS Ex15-263T>C, and SHMT1 Ex12+138C>T and Ex12+236C>T...
  38. Sun K, Song J, Liu K, Fang K, Wang L, Wang X, et al. Associations between homocysteine metabolism related SNPs and carotid intima-media thickness: a Chinese sib pair study. J Thromb Thrombolysis. 2017;43:401-410 pubmed publisher
    ..for Hcy, vitamin B6 (VB6), vitamin B12 (VB12) and folic acid (FA), and genotyped 9 SNPs on MTHFR, MTR, MTRR, BHMT, SHMT1, CBS genes...
  39. Vainer A, Boiarskikh U, Voronina E, Selezneva I, Sinkina T, Lazarev A, et al. [Polymorphic variants of folate metabolizing genes (C677T and A1298C MTHFR, C1420T SHMT1 and G1958A MTHFD) are not associated with the risk of breast cancer in West Siberian Region of Russia]. Mol Biol (Mosk). 2010;44:816-23 pubmed
    ..We investigated the role of polymorphisms of folate metabolizing genes MTHFR (C677T and A1298C), SHMT1 (C1420T) and MTHFD (G1258A) in genetic susceptibility to this type of cancer...
  40. Zhong S, Zhang J, Hu Q, Chen W, Ma T, Zhao J. C1420T polymorphism of cytosolic serine hydroxymethyltransferase and risk of cancer: a meta-analysis. Asian Pac J Cancer Prev. 2014;15:2257-62 pubmed
    A series of studies have explored the role of cytosolic serine hydroxymethyltransferase (SHMT1) C1420T polymorphism in cancer risk, but their results were conflicting rather than conclusive...
  41. Kim W, Woo H, Lee J, Choi I, Kim Y, Sung J, et al. Dietary folate, one-carbon metabolism-related genes, and gastric cancer risk in Korea. Mol Nutr Food Res. 2016;60:337-45 pubmed publisher the coding region with a minor allele frequency > 5%: MTHFR (G1793A, A1298C, C677T), MTR A2756G, MTRR A66G, SHMT1 C1420T, and SLC19A1 G80A. Our study found that MTR A2756G was associated with a decreased gastric cancer risk...
  42. Jiang Y, Kuang L, Sun S, Duan W, Qiao B, Wang H. Association of genetic polymorphisms of de novo nucleotide biosynthesis with increased CHD susceptibility in the northern Chinese population. Clin Genet. 2017;91:748-755 pubmed publisher
    ..Nine tagSNPs of four genes (GART, ATIC, MTHFD1 and SHMT1) in de novo nucleotide biosynthesis were sequenced in 802 sporadic CHD patients and 1093 controls from two Han ..
  43. de Jonge R, Tissing W, Hooijberg J, Jansen G, Kaspers G, Lindemans J, et al. Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia. Blood. 2009;113:2284-9 pubmed publisher
    ..MTHFD1 1958G>A), nicotinamide N-methyltransferase (NNMT IVS -151C>T), serine hydroxymethyl transferase (SHMT1 1420C>T), thymidylate synthase (TS 2R3R), and the reduced folate carrier (RFC1 80G>A) were detected...
  44. Yang Y, Lin D, Chang S, Lin S, Lin S, Chiou R, et al. Pharmacogenomic variations in treatment protocols for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2010;54:206-11 pubmed publisher
    ..The hazard ratios were 6.8 (p = 0.01), 21.7 (p = 0.009), and 6.8 (p = 0.01), respectively. Independent pharmacogenomic determinants associated with treatment outcome were identified in subsets of Taiwanese ALL patients. ..
  45. Hebbring S, Chai Y, Ji Y, Abo R, Jenkins G, Fridley B, et al. Serine hydroxymethyltransferase 1 and 2: gene sequence variation and functional genomic characterization. J Neurochem. 2012;120:881-90 pubmed publisher
    ..This reaction plays an important role in neurotransmitter synthesis and metabolism. We set out to resequence SHMT1 and SHMT2, followed by functional genomic studies...
  46. Pabalan N, Jarjanazi H, Ozcelik H. A meta-analysis of the C1420T polymorphism in cytosolic serine hydroxymethyltransferase (SHMT1) among Caucasian colorectal cancer populations. Int J Colorectal Dis. 2013;28:925-32 pubmed publisher
    ..of reported associations between the C1420T polymorphism in the cytosolic serine hydroxymethyltransferase (SHMT1) gene and colorectal cancer (CRC) prompted us to undertake a meta-analysis...
  47. Skibola C, Forrest M, Coppede F, Agana L, Hubbard A, Smith M, et al. Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphoma. Blood. 2004;104:2155-62 pubmed
    ..5,10-methylenetetrahydrofolate reductase (MTHFR 677C>T and 1298A>C); serine hydroxymethyltransferase (SHMT1 C1420T); reduced folate carrier (RFC G80A); and methionine synthase (MTR A2756G), making the present study the ..
  48. Giusti B, Saracini C, Bolli P, Magi A, Sestini I, Sticchi E, et al. Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. J Med Genet. 2008;45:721-30 pubmed publisher
    ..56 polymorphisms in MTHFR, MTR, MTRR, CBS, MTHFD1, SLC19A1, NNMT, TCN2, AHCY, BHMT, BHMT2, FOLH1, TYMS, ENOSF1, SHMT1, PON1, PON2 genes according to their demonstrated/putative function, localisation in promoter or regulatory and ..
  49. Paiardini A, Tramonti A, Schirch D, Guiducci G, di Salvo M, Fiascarelli A, et al. Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming. Biochim Biophys Acta. 2016;1864:1506-17 pubmed publisher
    The cytosolic and mitochondrial isoforms of serine hydroxymethyltransferase (SHMT1 and SHMT2, respectively) are well-recognized targets of cancer research, since their activity is critical for purine and pyrimidine biosynthesis and ..
  50. Bouchard G, Therriault H, Geha S, Bujold R, Saucier C, Paquette B. Radiation-induced lung metastasis development is MT1-MMP-dependent in a triple-negative breast cancer mouse model. Br J Cancer. 2017;116:479-488 pubmed publisher
    ..D2A1 cell lines showing downregulated expression of MT1-MMP, which were compared with D2A1-wt (wild-type) and D2A1 shMT1-mock (empty vector) cell lines...
  51. Paone A, Marani M, Fiascarelli A, Rinaldo S, Giardina G, Contestabile R, et al. SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation. Cell Death Dis. 2014;5:e1525 pubmed publisher several cancer types and as a hot target for anticancer therapies, the role of the cytoplasmic isoform (SHMT1) in cancerogenesis is currently less defined...
  52. Song J, Kim D, Chun C, Jin E. miR-370 and miR-373 regulate the pathogenesis of osteoarthritis by modulating one-carbon metabolism via SHMT-2 and MECP-2, respectively. Aging Cell. 2015;14:826-37 pubmed publisher
    ..We found that the expression levels of SHMT-2 and MECP-2 were increased in OA chondrocytes, and 3'UTR reporter assays showed that SHMT-2 and MECP-2 are the ..
  53. Mundhada H, Schneider K, Christensen H, Nielsen A. Engineering of high yield production of L-serine in Escherichia coli. Biotechnol Bioeng. 2016;113:807-16 pubmed publisher deletion of three L-serine deaminases sdaA, sdaB, and tdcG, as well as serine hydroxyl methyl transferase (SHMT) encoded by glyA...
  54. Kamynina E, Lachenauer E, DiRisio A, Liebenthal R, Field M, Stover P. Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis. Proc Natl Acad Sci U S A. 2017;114:E2319-E2326 pubmed publisher cultured cells and in in vitro SUMOylation reactions, and increased MTHFD1 ubiquitination and MTHFD1 and SHMT1 degradation...
  55. Wan Y. New Mechanism of Bone Cancer Pain: Tumor Tissue-Derived Endogenous Formaldehyde Induced Bone Cancer Pain via TRPV1 Activation. Adv Exp Med Biol. 2016;904:41-58 pubmed publisher
    ..We found that cancer cells produced formaldehyde through demethylation process by serine hydroxymethyltransferase (SHMT1 and SHMT2) and lysine-specific histone demethylase 1 (LSD1)...
  56. Oda Y, Fujita Y, Oishi K, Nakata Y, Takase M, Niitsu T, et al. Alterations in glutamatergic signaling in the brain of dopamine supersensitivity psychosis and non-supersensitivity psychosis model rats. Psychopharmacology (Berl). 2017;234:3027-3036 pubmed publisher
    ..of N-methyl-D-aspartate receptors (NMDAR), glutamic acid decarboxylase (GAD), and serine hydroxymethyltransferase (SHMT) in the rat brain regions were examined...
  57. Moruzzi S, Guarini P, Udali S, Ruzzenente A, Guglielmi A, Conci S, et al. One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation. PLoS ONE. 2017;12:e0185792 pubmed publisher
    ..716A>G, DHFR 19bp ins/del, MTHFD1 1958G>A, MTHFR 677C>T, MTR 2756A>G, MTRR 66A>G, RFC1 80G>A, SHMT1 1420C>T, TCII 776C>G and TS 2rpt-3rpt was performed in 102 cancer patients and 363 cancer-free subjects...
  58. Aljaafri W, McNeece B, Lawaju B, Sharma K, Niruala P, Pant S, et al. A harpin elicitor induces the expression of a coiled-coil nucleotide binding leucine rich repeat (CC-NB-LRR) defense signaling gene and others functioning during defense to parasitic nematodes. Plant Physiol Biochem. 2017;121:161-175 pubmed publisher
    ..alpha soluble N-ethylmaleimide-sensitive fusion protein (?-SNAP) and serine hydroxymethyltransferase (SHMT). In contrast, other defense genes are not directly transcriptionally activated by harpin...
  59. Boyles A, Billups A, Deak K, Siegel D, Mehltretter L, Slifer S, et al. Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. Environ Health Perspect. 2006;114:1547-52 pubmed
  60. Najer A, Wu D, Nussbaumer M, Schwertz G, Schwab A, Witschel M, et al. An amphiphilic graft copolymer-based nanoparticle platform for reduction-responsive anticancer and antimalarial drug delivery. Nanoscale. 2016;8:14858-69 pubmed publisher
    ..HeLa cells) and an experimental, metabolically unstable antimalarial drug (the serine hydroxymethyltransferase (SHMT) inhibitor (±)-1) to Plasmodium falciparum-infected red blood cells (iRBCs), with higher efficacy compared to ..
  61. Palmer A, Kamynina E, Field M, Stover P. Folate rescues vitamin B12 depletion-induced inhibition of nuclear thymidylate biosynthesis and genome instability. Proc Natl Acad Sci U S A. 2017;114:E4095-E4102 pubmed publisher
    ..These studies also revealed that 5-formylTHF, a slow, tight-binding inhibitor of serine hydroxymethyltransferase (SHMT), was enriched in nuclei, accounting for 35% of folate cofactors, explaining previous observations that nuclear ..
  62. Singh R, Avliyakulov N, Braga M, Haykinson M, Martinez L, Singh V, et al. Proteomic identification of mitochondrial targets of arginase in human breast cancer. PLoS ONE. 2013;8:e79242 pubmed publisher
    ..As mSHMT is a key player in folate metabolism, our data provides a novel link between arginine and folate metabolism in human breast cancer, both of which are critical for tumor cell proliferation. ..
  63. Kruschwitz H, Ren S, di Salvo M, Schirch V. Expression, purification, and characterization of human cytosolic serine hydroxymethyltransferase. Protein Expr Purif. 1995;6:411-6 pubmed
    ..Kinetic constants for the natural substrates L-serine and tetrahydrofolate were also similar to the values obtained previously for the rabbit cytosolic enzyme. ..
  64. Heil S, van der Put N, Waas E, Den Heijer M, Trijbels F, Blom H. Is mutated serine hydroxymethyltransferase (SHMT) involved in the etiology of neural tube defects?. Mol Genet Metab. 2001;73:164-72 pubmed
    ..Two different isoforms of SHMT are known, one is present in the cytosol (cSHMT) and the other in the mitochondrion (mSHMT)...
  65. Dean J, Robertson Z, Reid V, Wang Q, Hailey H, Moore S, et al. A high frequency of the MTHFR 677C>T polymorphism in Scottish women with epilepsy: possible role in pathogenesis. Seizure. 2008;17:269-75 pubmed
    ..from maternity hospital records and genotyped for polymorphisms in MTHFR, serine hydroxymethyl transferase (SHMT1), methionine synthase (MTR) and methionine synthase reductase (MTRR)...
  66. Oterino A, Toriello M, Valle N, Castillo J, Alonso Arranz A, Bravo Y, et al. The relationship between homocysteine and genes of folate-related enzymes in migraine patients. Headache. 2010;50:99-168 pubmed publisher
    ..Determination of MTHFR C677T polymorphisms and Hcy levels may be useful to identify patients with a high risk of suffering from MA. ..
  67. Levine A, Figueiredo J, Lee W, Conti D, Kennedy K, Duggan D, et al. A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2010;19:1812-21 pubmed publisher
    ..This study suggests that multivitamin supplement use may modify the association between folate pathway genes and colorectal cancer risk in a post-folic-acid-supplemented population. ..
  68. Dunna N, Naushad S, Vuree S, Anuradha C, Sailaja K, Surekha D, et al. Association of thymidylate synthase 5'-UTR 28bp tandem repeat and serine hydroxymethyltransfarase C1420T polymorphisms with susceptibility to acute leukemia. Asian Pac J Cancer Prev. 2014;15:1719-23 pubmed
    ..of thymidylate synthase (TYMS) 5'- UTR 28bp tandem repeat and cytosolic serine hydroxymethyltransferase (cSHMT) C1420T polymorphisms with acute leukemia in South Indian subjects...
  69. Giardina G, Brunotti P, Fiascarelli A, Cicalini A, Costa M, Buckle A, et al. How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state. FEBS J. 2015;282:1225-41 pubmed publisher
    ..In humans, the cytosolic isoform (SHMT1) and the mitochondrial isoform (SHMT2) have distinct cellular roles, but high sequence identity and comparable ..
  70. Park S, Moon J, Shin S, Son H, Jung Y, Kim N, et al. Functional characterization of alpha-synuclein protein with antimicrobial activity. Biochem Biophys Res Commun. 2016;478:924-8 pubmed publisher
    ..We also analyzed localizations of recombinant ?-Syn protein in E. coli and Candida albicans. These results suggest that in addition to ?-Syn's role in neurotransmitter release, it appears to be a natural AMP. ..
  71. Renwick S, Snell K, Baumann U. The crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapy. Structure. 1998;6:1105-16 pubmed
    Serine hydroxymethyltransferase (SHMT) is a ubiquitous enzyme found in all prokaryotes and eukaryotes...
  72. Lakhey H, Rao A, Prakash V, Krishnaswamy P, Savithri H, Rao N, et al. Affinity properties of phosvitin: interaction of phosvitin with serine hydroxymethyl transferase. Indian J Biochem Biophys. 1999;36:69-76 pubmed
    The affinity of phosvitin with serine hydroxymethyl transferase (SHMT), an acidic multi-subunit protein, was evaluated by measurements of enzyme activity, sedimentation velocity, steady-state fluorescence, circular dichroism and kinetic ..
  73. Relton C, Wilding C, Pearce M, Laffling A, Jonas P, Lynch S, et al. Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population. J Med Genet. 2004;41:256-60 pubmed
    ..for proteins in the folate-dependent homocysteine pathway (MTHFR 677C-->T, MTHFR 1298A-->C, MTRR 66A-->G, SHMT 1420C-->T, CbetaS 844ins68, GCPII 1561C-->T, RFC-1 80G-->A)...
  74. Ohnuma T, Shibata N, Maeshima H, Baba H, Hatano T, Hanzawa R, et al. Association analysis of glycine- and serine-related genes in a Japanese population of patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:511-8 pubmed publisher
    ..Case-control genetic association analysis of PHGDH, SHMT1, SRR, and DAO was performed...
  75. Goldmuntz E, Woyciechowski S, Renstrom D, Lupo P, Mitchell L. Variants of folate metabolism genes and the risk of conotruncal cardiac defects. Circ Cardiovasc Genet. 2008;1:126-32 pubmed publisher
  76. Stamp L, Chapman P, O Donnell J, Zhang M, James J, Frampton C, et al. Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexate. Pharmacogenet Genomics. 2010;20:367-76 pubmed publisher
    ..002), MTRR 66A>G (P<0.0001), MTHFD1 1958G>A (P=0.001) and SHMT 1420C>T (P=0.012), whereas no association of these polymorphisms with disease activity was observed...
  77. Naushad S, Prayaga A, Digumarti R, Gottumukkala S, Kutala V. Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) expression is epigenetically regulated by one-carbon metabolism in invasive duct cell carcinoma of breast. Mol Cell Biochem. 2012;361:189-95 pubmed publisher
    ..002); inverse association with cytosolic serine hydroxyl methyltransferase (cSHMT) C1420T (P < 0.005) and 8-oxodG (<10% vs. >10% methylation: 7.24 ± 2.77 ng/ml vs. 4.42 ± 2...
  78. Wang Q, Lu K, Du H, Zhang Q, Chen T, Shu Y, et al. Association between cytosolic serine hydroxymethyltransferase (SHMT1) gene polymorphism and cancer risk: a meta-analysis. Biomed Pharmacother. 2014;68:757-62 pubmed publisher
    The serine hydroxymethyltransferase (SHMT1) is the key enzyme in the folate metabolic pathway to provide one-carbon unit that plays an important role in biosynthesis...
  79. Zwart S, Gregory J, Zeisel S, Gibson C, Mader T, Kinchen J, et al. Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes. FASEB J. 2016;30:141-8 pubmed publisher
    ..The number of G alleles of MTRR 66 and C alleles of SHMT1 1420 both contributed to the odds of visual disturbances...
  80. Yu C, Wu M, Chou Y, Yang T, You S, Chen C, et al. Breast cancer risk associated with multigenotypic polymorphisms in folate-metabolizing genes: a nested case-control study in Taiwan. Anticancer Res. 2007;27:1727-32 pubmed
    ..The polymorphisms in serine hydroxymethyltransferase (SHMT1 C1420T), 5,10-methylenetetrahydrofolate reductase (MTHFR C677T), and methionine synthase (MS A2756G) genes were ..
  81. Kelemen L, Sellers T, Schildkraut J, Cunningham J, Vierkant R, Pankratz V, et al. Genetic variation in the one-carbon transfer pathway and ovarian cancer risk. Cancer Res. 2008;68:2498-506 pubmed publisher
    ..Each copy of the minor allele in SHMT1 intron 5 A>G (rs9909104) was associated with epithelial ovarian cancer [odds ratio (OR), 1...
  82. Mitchell L, Long J, Garbarini J, Paluru P, Goldmuntz E. Variants of folate metabolism genes and risk of left-sided cardiac defects. Birth Defects Res A Clin Mol Teratol. 2010;88:48-53 pubmed publisher
    ..However, even larger studies and more comprehensive evaluations of the folate pathway genes are required to fully explore the relationship between folate and left-sided cardiac defects. ..
  83. Lightfoot T, Johnston W, Painter D, Simpson J, Roman E, Skibola C, et al. Genetic variation in the folate metabolic pathway and risk of childhood leukemia. Blood. 2010;115:3923-9 pubmed publisher
    ..the association between polymorphisms in key folate metabolism enzymes (MTHFR 677 C>T, MTHFR 1298 A>C, SHMT1 1420 C>T, MTR 2756 A>G, TS 1494del6, and TS 28bp repeat) in 939 cases of childhood acute lymphoblastic ..
  84. K Rebekah P, Tella S, Buragadda S, Tiruvatturu M, Akka J. Interaction between Maternal and Paternal SHMT1 C1420T Predisposes to Neural Tube Defects in the Fetus: Evidence from Case-Control and Family-Based Triad Approaches. Birth Defects Res. 2017;109:1020-1029 pubmed publisher
    ..NTDs are the most severe and leading cause of fetal mortality. Serine hydroxymethyl transferase (SHMT1) provides one-carbon units necessary for embryogenesis and defects in one-carbon production result in specific ..
  85. Schwertz G, Frei M, Witschel M, Rottmann M, Leartsakulpanich U, Chitnumsub P, et al. Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs. Chemistry. 2017;23:14345-14357 pubmed publisher
    ..aryl sulfonamide, or aryl sulfone motifs were synthesized and tested towards serine hydroxymethyltransferase (SHMT), a key enzyme of the folate cycle...
  86. Li C, Plamont M, Sladitschek H, Rodrigues V, Aujard I, Neveu P, et al. Dynamic multicolor protein labeling in living cells. Chem Sci. 2017;8:5598-5605 pubmed publisher
  87. Byrne P, Shipley J, Chave K, Sanders P, Snell K. Characterisation of a human serine hydroxymethyltransferase pseudogene and its localisation to 1p32.3-33. Hum Genet. 1996;97:340-4 pubmed
    ..of serine and tetrahydrofolate to glycine and 5,10 methylene tetrahydrofolate by serine hydroxymethyltransferase (SHMT, EC is the major route for the provision of one-carbon units for biosynthetic reactions...
  88. Szebenyi D, Liu X, Kriksunov I, Stover P, Thiel D. Structure of a murine cytoplasmic serine hydroxymethyltransferase quinonoid ternary complex: evidence for asymmetric obligate dimers. Biochemistry. 2000;39:13313-23 pubmed
    ..The crystal structure of a close analogue of the inactive form of murine cytoplasmic SHMT (cSHMT), lacking only the polyglutamate tail of the inhibitor, has been determined to 2.9 A resolution...
  89. Oppenheim E, Adelman C, Liu X, Stover P. Heavy chain ferritin enhances serine hydroxymethyltransferase expression and de novo thymidine biosynthesis. J Biol Chem. 2001;276:19855-61 pubmed
    ..chain ferritin (HCF) exhibited markedly increased expression of the folate-dependent enzyme cytoplasmic serine hydroxymethyltransferase (cSHMT). These effects were not seen when rat light chain ferritin was expressed...
  90. de Jonge R, Hooijberg J, van Zelst B, Jansen G, Jansen G, van Zantwijk C, et al. Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia. Blood. 2005;106:717-20 pubmed
    ..MTRR 66A>G), methylenetetrahydrofolate dehydrogenase (MTHFD1 1958G>A), serine hydroxymethyl transferase (SHMT1 1420C>T), thymidylate synthase (TS 2R3R), and the reduced folate carrier (RFC 80G>A) were detected by ..
  91. Lightfoot T, Skibola C, Willett E, Skibola D, Allan J, Coppede F, et al. Risk of non-Hodgkin lymphoma associated with polymorphisms in folate-metabolizing genes. Cancer Epidemiol Biomarkers Prev. 2005;14:2999-3003 pubmed
    ..MTHFR) 677 C >T and 1298 A >C, methionine synthase (MTR) 2756 A>G, serine hydroxymethyltransferase (SHMT1) 1420 C >T, thymidylate synthase (TYMS) 1494del6 and 28-bp repeat, and reduced folate carrier (RFC) 80 G >A...