SHIP2

Summary

Gene Symbol: SHIP2
Description: inositol polyphosphate phosphatase-like 1
Alias: OPSMD, SHIP2, 51C protein, INPPL-1, SH2 domain-containing inositol 5'-phosphatase 2, SH2 domain-containing inositol-5'-phosphatase 2, SHIP-2, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2, protein 51C
Species: human

Top Publications

  1. doi Lipid phosphatase SHIP2 downregulates insulin signalling in podocytes
    Mervi E Hyvönen
    Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Mol Cell Endocrinol 328:70-9. 2010
  2. pmc Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes
    Ji Hee Yun
    Department of Physiology, Ewha Womans University School of Medicine Seoul 158 710, Korea
    Exp Mol Med 43:660-8. 2011
  3. pmc Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension
    Ana Carolina Braga Marçano
    J Med Genet 44:603-5. 2007
  4. pmc Whole-genome analysis reveals that mutations in inositol polyphosphate phosphatase-like 1 cause opsismodysplasia
    Jennifer E Below
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 92:137-43. 2013
  5. ncbi A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells
    D Wisniewski
    Sloan Kettering Institute for Cancer Research, Molecular Pharmacology and Therapeutics Program and Molecular Biology Program, New York, NY, USA
    Blood 93:2707-20. 1999
  6. doi Phosphoinositides influence pathogen surfing: EPEC rights the SHIP
    Kenneth G Campellone
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell Host Microbe 7:1-2. 2010
  7. doi Enteropathogenic Escherichia coli recruits the cellular inositol phosphatase SHIP2 to regulate actin-pedestal formation
    Katherine Smith
    University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB21QP, UK
    Cell Host Microbe 7:13-24. 2010
  8. pmc The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin
    J M Dyson
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800 Australia
    J Cell Biol 155:1065-79. 2001
  9. ncbi SH2-containing 5'-inositol phosphatase, SHIP2, regulates cytoskeleton organization and ligand-dependent down-regulation of the epidermal growth factor receptor
    Nagendra K Prasad
    Department of Basic Medical Sciences and Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 280:13129-36. 2005
  10. ncbi Src family tyrosine kinases regulate adhesion-dependent tyrosine phosphorylation of 5'-inositol phosphatase SHIP2 during cell attachment and spreading on collagen I
    Nagendra Prasad
    Department of Cancer Molecular Sciences, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    J Cell Sci 115:3807-15. 2002

Research Grants

  1. The Role of MicroRNAs in Corneal Epithelial Homeostasis
    Robert M Lavker; Fiscal Year: 2010
  2. Mechanisms of Chemo/Radioresistance in Human Gliomas
    Eliot M Rosen; Fiscal Year: 2010
  3. Intracellular pathways of monocyte survival
    Clay B Marsh; Fiscal Year: 2010
  4. Intracellular pathways of monocyte survival
    Clay Marsh; Fiscal Year: 2009
  5. FACTORS THAT MODIFY INSULIN ACTION
    MARIA BUSE; Fiscal Year: 2006
  6. Identification of Signaling Targets of EphA2
    Sonja Schmidt; Fiscal Year: 2005
  7. The Role of PtdIns-5-P in Cell Function and Signaling
    LUCIA RAMEH PLANT; Fiscal Year: 2004
  8. The Role of PtdIns-5-P in Cell Function and Signaling
    LUCIA RAMEH PLANT; Fiscal Year: 2007
  9. SEARCH FOR SELECTIVE THERAPY OF CML
    Bayard Clarkson; Fiscal Year: 2007
  10. LIPID PHOSPHATASE ASSAYS IN DISEASE AND DRUG DISCOVERY
    BETH DREES; Fiscal Year: 2002

Scientific Experts

Detail Information

Publications130 found, 100 shown here

  1. doi Lipid phosphatase SHIP2 downregulates insulin signalling in podocytes
    Mervi E Hyvönen
    Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Mol Cell Endocrinol 328:70-9. 2010
    ..a glomerular library, and found that CD2AP bound to SH2-domain-containing inositol polyphosphate 5-phosphatase 2 (SHIP2), a negative regulator of insulin signalling...
  2. pmc Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes
    Ji Hee Yun
    Department of Physiology, Ewha Womans University School of Medicine Seoul 158 710, Korea
    Exp Mol Med 43:660-8. 2011
    ..Our results suggest that caveolin-1 is involved in astrocyte-specific intracellular responses linked to the SHP-2-mediated signaling cascade following ROS-induced oxidative stress...
  3. pmc Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension
    Ana Carolina Braga Marçano
    J Med Genet 44:603-5. 2007
    Inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) is a negative regulator of insulin signalling and has previously been found to be associated with hypertension, obesity and type 2 diabetes in a cohort of families with diabetes ..
  4. pmc Whole-genome analysis reveals that mutations in inositol polyphosphate phosphatase-like 1 cause opsismodysplasia
    Jennifer E Below
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 92:137-43. 2013
    ..Evaluation of 12 families with opsismodysplasia revealed that INPPL1 mutations explain ~60% of cases overall, including both of the families in our cohort with more than one affected child and 50% of the simplex cases...
  5. ncbi A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells
    D Wisniewski
    Sloan Kettering Institute for Cancer Research, Molecular Pharmacology and Therapeutics Program and Molecular Biology Program, New York, NY, USA
    Blood 93:2707-20. 1999
    ..associated with src homologous and collagen gene (SHC) from p210(bcr/abl)-expressing hematopoietic cells as SHIP2, a recently reported, unique SH2-domain-containing protein closely related to phosphatidylinositol polyphosphate 5-..
  6. doi Phosphoinositides influence pathogen surfing: EPEC rights the SHIP
    Kenneth G Campellone
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell Host Microbe 7:1-2. 2010
    ..A recent study now shows that two additional tyrosines within Tir recruit the inositol phosphatase SHIP2 to generate a PI(3,4)P2-enriched membrane platform that stabilizes pedestal assembly.
  7. doi Enteropathogenic Escherichia coli recruits the cellular inositol phosphatase SHIP2 to regulate actin-pedestal formation
    Katherine Smith
    University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB21QP, UK
    Cell Host Microbe 7:13-24. 2010
    ..We demonstrate that Y483 and Y511 within tandem ITIM-like sequences are essential for recruiting SHIP2, a host inositol phosphatase...
  8. pmc The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin
    J M Dyson
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800 Australia
    J Cell Biol 155:1065-79. 2001
    ..Collectively these studies demonstrate that filamin-dependent SHIP-2 localization critically regulates phosphatidylinositol 3 kinase signaling to the actin cytoskeleton...
  9. ncbi SH2-containing 5'-inositol phosphatase, SHIP2, regulates cytoskeleton organization and ligand-dependent down-regulation of the epidermal growth factor receptor
    Nagendra K Prasad
    Department of Basic Medical Sciences and Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 280:13129-36. 2005
    ..b>SHIP2 dephosphorylates phosphatidylinositol 3,4,5-trisphosphate generated by the activated phosphatidylinositol 3'-..
  10. ncbi Src family tyrosine kinases regulate adhesion-dependent tyrosine phosphorylation of 5'-inositol phosphatase SHIP2 during cell attachment and spreading on collagen I
    Nagendra Prasad
    Department of Cancer Molecular Sciences, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    J Cell Sci 115:3807-15. 2002
    ..Recently we have reported a novel function for SHIP2 in cell adhesion and spreading...
  11. ncbi The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner
    Judith H Raaijmakers
    Department of Physiological Chemistry and Centre of Biomedical Genetics, UMC Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Cell Signal 19:1249-57. 2007
    ..In a yeast two-hybrid screen for new interaction partners of Arap3, we identified the PI 5'-phosphatase SHIP2 as an interaction partner of Arap3...
  12. ncbi Cloning and characterization of a human cDNA (INPPL1) sharing homology with inositol polyphosphate phosphatases
    J A Hejna
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA
    Genomics 29:285-7. 1995
    ..Several polymorphisms have been mapped to the 3'-untranslated region, yet the putative coding region showed no polymorphisms in nine independent cDNA samples...
  13. pmc Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity
    T Wada
    First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Mol Cell Biol 21:1633-46. 2001
    ..We recently cloned rat SH2-containing inositol phosphatase 2 (SHIP2) cDNA which possesses the 5'-phosphatase activity to hydrolyze PI(3,4,5)P3 to PI 3,4-bisphosphate [PI(3,4)P2] and ..
  14. pmc SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading
    N Prasad
    Department of Cell Biology, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Mol Cell Biol 21:1416-28. 2001
    In a previous study, we found that the SHIP2 protein became tyrosine phosphorylated and associated with the Shc adapter protein in response to the treatment of cells with growth factors and insulin (T. Habib, J. A. Hejna, R. E...
  15. ncbi Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP
    X Pesesse
    Interdisciplinary Research Institute IRIBHN, Universite Libre de Bruxelles, Belgium
    Biochem Biophys Res Commun 239:697-700. 1997
    ..new SH2-domain-containing protein showing homology to the inositol 5-phosphatase SHIP and therefore referred to as SHIP2. SHIP2 differs at both N- and C-terminal ends with the sequence of INPPL-1...
  16. ncbi Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein
    T Habib
    Department of Cell Biology, Parke Davis Pharmaceutical Research Division, Ann Arbor, Michigan 48105, USA
    J Biol Chem 273:18605-9. 1998
    Antibodies raised against the 51C/SHIP2 inositol polyphosphate 5'-phosphatase were used to examine the effects of growth factors and insulin on the metabolism of this protein...
  17. ncbi The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity
    X Pesesse
    Interdisciplinary Research Institute IRIBHN, Universite Libre de Bruxelles, Brussels, Belgium
    FEBS Lett 437:301-3. 1998
    ..SHIP1 is the 145-kDa SH2 domain-containing inositol 5-phosphatase expressed in haematopoietic cells. SHIP2 is a related but distinct gene product...
  18. pmc NMR studies of a heterotypic Sam-Sam domain association: the interaction between the lipid phosphatase Ship2 and the EphA2 receptor
    Marilisa Leone
    Burnham Institute for Medical Research, La Jolla, California, USA
    Biochemistry 47:12721-8. 2008
    ..It has been recently reported that the lipid phosphatase Ship2 regulates endocytosis of the EphA2 receptor, a process that has been investigated as a possible route to reduce ..
  19. ncbi Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation
    Guanglei Zhuang
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 282:2683-94. 2007
    ..Here we show that SHIP2 (Src homology 2 domain-containing phosphoinositide 5-phosphatase 2) is recruited to activated EphA2 via a ..
  20. ncbi SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes
    Toshiyasu Sasaoka
    Department of Clinical Pharmacology and First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Biol Chem 279:14835-43. 2004
    SH2-containing inositol phosphatase 2 (SHIP2) is a physiologically important negative regulator of insulin signaling by hydrolyzing the phosphatidylinositol (PI) 3-kinase product PI 3,4,5-trisphosphate in the target tissues of insulin...
  21. ncbi Dual role of SRC homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor I signaling in rat vascular smooth muscle cells
    Toshiyasu Sasaoka
    Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Endocrinology 144:4204-14. 2003
    Src homology domain 2 (SH2)-containing inositol phosphatase 2 (SHIP2) possesses 5-phosphatase activity and an SH2 domain...
  22. doi Gene expression in canine atopic dermatitis and correlation with clinical severity scores
    Shona H Wood
    Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool, UK
    J Dermatol Sci 55:27-33. 2009
    ..Canine atopic dermatitis (cAD) is a common condition in dogs that may be a naturally occurring model for human atopic dermatitis (hAD). Despite this, comparative research is limited, particularly into the genetic background of cAD...
  23. ncbi PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes
    Xiaoqing Tang
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    J Biol Chem 280:22523-9. 2005
    ..in mice suggested that two phosphoinositide phosphatases, SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) negatively regulate this insulin signaling ..
  24. ncbi Reversal of denervation-induced insulin resistance by SHIP2 protein synthesis blockade
    Daniela F Bertelli
    Department of Physiology and Biophysics, University of Campinas 6040 Campinas SP, Brazil
    Am J Physiol Endocrinol Metab 284:E679-87. 2003
    ..the expression and activity of the 5-inositol, lipid phosphatase SH2 domain-containing inositol phosphatase (SHIP2), and the serine phosphorylation of p85/PI 3-kinase...
  25. ncbi Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing
    Zhiyang Gao
    Department of Pathology, Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Biol Chem 280:9375-89. 2005
    ..Overexpression of the phospholipid phosphatases, SHIP2 and/or PTEN, inhibited PDGF-BB-induced phosphorylation of Akt and ERK1/2 in PDGFR-betaDelta/Delta fibroblasts but ..
  26. doi The inositol phosphatase SHIP2 negatively regulates insulin/IGF-I actions implicated in neuroprotection and memory function in mouse brain
    Yoshiyuki Soeda
    Department of Clinical Pharmacology, University of Toyama, Toyama, Japan
    Mol Endocrinol 24:1965-77. 2010
    ..In the present study, we found that SH2-containing inositol 5'-phosphatase 2 (SHIP2), a negative regulator of phosphatidylinositol 3,4,5-trisphosphate-mediated signals, is widely expressed in adult ..
  27. ncbi Normalization of prandial blood glucose and improvement of glucose tolerance by liver-specific inhibition of SH2 domain containing inositol phosphatase 2 (SHIP2) in diabetic KKAy mice: SHIP2 inhibition causes insulin-mimetic effects on glycogen metabolism
    Rolf Grempler
    Department of Metabolic Diseases, Boehringer Ingelheim GmbH and Co KG, Biberach, Germany
    Diabetes 56:2235-41. 2007
    ..Recent data have established the lipid phosphatase SH2 domain-containing inositol phosphatase 2 (SHIP2) as a critical negative regulator of insulin signal transduction...
  28. ncbi Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signaling
    H Ishihara
    First Department of Medicine, Toyama Medical and Pharmaceutical University, Toyama, 930 0194, Japan
    Biochem Biophys Res Commun 260:265-72. 1999
    ..We have now cloned the rat SHIP isozyme (SHIP2) cDNA from skeletal muscle, which is one of the most important target tissue of insulin action...
  29. pmc SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels
    Sylvie Giuriato
    INSERM U563, Department of Oncogenesis and Signaling in Hematopoietic Cells, IFR30, Hopital Purpan, 31059 Toulouse Cedex, France
    Biochem J 376:199-207. 2003
    Src homology domain 2-containing inositol 5-phosphatases 1 and 2 (SHIP1 and SHIP2) are capable of dephosphorylating the second messenger PtdIns(3,4,5) P3 (phosphatidylinositol 3,4,5-trisphosphate) and interacting with several signalling ..
  30. ncbi Relationship between spleen tyrosine kinase and phosphatidylinositol 5' phosphatase expression and secretion from human basophils in the general population
    Donald W Macglashan
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 119:626-33. 2007
    ..Previous studies have suggested that expression levels of spleen tyrosine kinase (syk) or phosphatidylinositol 5' phosphatase (SHIP) may explain certain extreme human basophil phenotypes...
  31. ncbi Mechanism of SHIP-mediated inhibition of insulin- and platelet-derived growth factor-stimulated mitogen-activated protein kinase activity in 3T3-L1 adipocytes
    Prem M Sharma
    Department of Medicine 0673, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0673, USA
    Mol Endocrinol 19:421-30. 2005
    The Src homology 2-containing 5' inositolphosphatases (SHIP and SHIP2) dephosphorylate 3'-phosphorylated PtdIns on the 5' position, decreasing intracellular levels of PtdIns 3,4,5-P3...
  32. ncbi Motif decomposition of the phosphotyrosine proteome reveals a new N-terminal binding motif for SHIP2
    Martin Lee Miller
    Center for Biological Sequence Analysis, Technical University of Denmark, Kemitorvet, Building 208, DK 2800 Lyngby, Denmark
    Mol Cell Proteomics 7:181-92. 2008
    ..was identified and validated as a binding motif for the SH2 domain-containing inositol phosphatase SHIP2. Our decomposition of the in vivo Tyr(P) proteome furthermore suggests that two-thirds of the Tyr(P) sites mediate ..
  33. doi The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease
    Lisa M Ooms
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Biochem J 419:29-49. 2009
    ..b>SHIP2 polymorphisms are associated with a predisposition to insulin resistance...
  34. ncbi Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity
    Toshiyasu Sasaoka
    Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Pharmacol Ther 112:799-809. 2006
    ..Lipid phosphatases, src homology 2 domain containing inositol 5'-phosphatase 2 (SHIP2) and skeletal muscle and kidney-enriched inositol phosphatase (SKIP) hydrolyze PI(3,4,5)P(3) to PI(3,4)P(2) and ..
  35. ncbi Phosphatidylinositol 3,4,5-trisphosphate modulation in SHIP2-deficient mouse embryonic fibroblasts
    Daniel Blero
    Interdisciplinary Research Institute IRIBHM, Universite Libre de Bruxelles, Belgium
    FEBS J 272:2512-22. 2005
    b>SHIP2, the ubiquitous SH2 domain containing inositol 5-phosphatase, includes a series of protein interacting domains and has the ability to dephosphorylate phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P(3)]in vitro...
  36. doi The docking properties of SHIP2 influence both JIP1 tyrosine phosphorylation and JNK activity
    Jingwei Xie
    Institute of Interdisciplinary Research IRIBHM, School of Medicine, Free University of Brussels, Campus Erasme, Building C, Route de Lennik 808, B 1070 Brussels, Belgium
    Cell Signal 20:1432-41. 2008
    b>SHIP2 (SH2-containing inositol polyphosphate 5-phosphatase 2) is an ubiquitously expressed phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P(3)) 5-phosphatase which contains various motifs susceptible to mediate protein-protein ..
  37. doi Catalytically inactive SHIP2 inhibits proliferation by attenuating PDGF signaling in 3T3-L1 preadipocytes
    Yulia Artemenko
    Chronic Disease Program, Ottawa Health Research Institute and Departments of Medicine and Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    J Cell Physiol 218:228-36. 2009
    ..SH2 domain-containing inositol 5-phosphatase 2 (SHIP2) dephosphorylates PI(3,4,5)P3, and also binds to Shc...
  38. ncbi Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity
    Mark W Sleeman
    Regeneron Pharmaceuticals, Inc 777 Old Saw Mill River Road, Tarrytown, New York 10591 6707, USA
    Nat Med 11:199-205. 2005
    Genetic ablation of Inppl1, which encodes SHIP2 (SH2-domain containing inositol 5-phosphatase 2), was previously reported to induce severe insulin sensitivity, leading to early postnatal death...
  39. ncbi The association between the SH2-containing inositol polyphosphate 5-Phosphatase 2 (SHIP2) and the adaptor protein APS has an impact on biochemical properties of both partners
    Sheela Onnockx
    Institute of Interdisciplinary Research IRIBHM, Brussels, Belgium
    J Cell Physiol 214:260-72. 2008
    b>SHIP2 (SH2-containing inositol polyphosphate 5-phosphatase 2) is a phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P(3)) 5-phosphatase containing various motifs susceptible to mediate protein-protein interaction...
  40. ncbi SHIP2 phosphoinositol phosphatase positively regulates EGFR-Akt pathway, CXCR4 expression, and cell migration in MDA-MB-231 breast cancer cells
    Nagendra K Prasad
    Department of Basic Medical Sciences and Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Int J Oncol 34:97-105. 2009
    The phosphoinositol phosphatase SHIP2 is an important regulator of energy metabolism...
  41. doi Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes
    Akira Suwa
    Drug Discovery Research, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba shi, Ibaraki 305 8585, Japan
    Eur J Pharmacol 642:177-82. 2010
    Lipid phosphatase SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) plays an important role in the regulation of insulin signaling. In this report, we identified AS1938909, a novel small-molecule SHIP2 inhibitor...
  42. pmc LL5beta directs the translocation of filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2
    Tetsuji Takabayashi
    Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, University of Fukui, Fukui 910 1193, Japan
    J Biol Chem 285:16155-65. 2010
    ..accumulates, with the Filamin A-binding Src homology 2 domain-containing inositol polyphosphate 5-phosphatase 2 (SHIP2)...
  43. ncbi Inhibitors of the lipid phosphatase SHIP2 discovered by high-throughput affinity selection-mass spectrometry screening of combinatorial libraries
    D Allen Annis
    Aileron Therapeutics, Inc, Cambridge, MA 02139, USA
    Comb Chem High Throughput Screen 12:760-71. 2009
    This manuscript describes the discovery and characterization of inhibitors of the lipid phosphatase SHIP2, an important target for the treatment of Type 2 diabetes, using the Automated Ligand Identification System...
  44. ncbi Metabolic switching of PI3K-dependent lipid signals
    C P Downes
    Division of Molecular Physiology, James Black Centre, College of Life Sciences, University of Dundee, Dundee, UK
    Biochem Soc Trans 35:188-92. 2007
    ..by a distinct family of enzymes exemplified by SHIP1 [SH2 (Src homology 2)-containing inositol phosphatase 1] and SHIP2. Mouse knockout studies, however, suggest that PTEN and SHIP2 have profoundly different biological functions...
  45. ncbi Endogenous SHIP2 does not localize in lipid rafts in 3T3-L1 adipocytes
    Christine Jacobs
    Faculte de Medecine, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, Universite Libre de Bruxelles, BatC 4 126, Route de Lennik 808, B 1070 Bruxelles, Belgium
    FEBS Lett 565:70-4. 2004
    SH2 domain containing inositol polyphosphate 5-phosphatase (SHIP2) dephosphorylates phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) into phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P(2))...
  46. ncbi Impact of transgenic overexpression of SH2-containing inositol 5'-phosphatase 2 on glucose metabolism and insulin signaling in mice
    Syota Kagawa
    Department of Clinical Pharmacology, University of Toyama, Toyama, Japan
    Endocrinology 149:642-50. 2008
    SH2-containing inositol 5'-phosphatase 2 (SHIP2) is a 5'-lipid phosphatase hydrolyzing the phosphatidylinositol (PI) 3-kinase product PI(3,4,5)P(3) to PI(3,4)P(2) in the regulation of insulin signaling, and is shown to be increased in ..
  47. ncbi The lipid phosphatase SHIP2 controls insulin sensitivity
    S Clement
    IRIBHN, IBMM, Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium
    Nature 409:92-7. 2001
    ..Type-II SH2-domain-containing inositol 5-phosphatase, or 'SHIP2', is a member of the inositol polyphosphate 5-phosphatase family...
  48. pmc The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics
    Fubito Nakatsu
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Cell Biol 190:307-15. 2010
    ..In this study, we show that the inositol 5-phosphatase SHIP2, a negative regulator of PI(3,4,5)P(3)-dependent signaling, also negatively regulates PI(4,5)P(2) levels and is ..
  49. ncbi SHIP2: an emerging target for the treatment of type 2 diabetes mellitus
    James W Baumgartener
    8491 N E Paulanna Lane, Bainbridge Island, WA 98110, USA
    Curr Drug Targets Immune Endocr Metabol Disord 3:291-8. 2003
    ..Mice lacking one of these enzymes, Src-Homology Inositol Phosphatase-2 (SHIP2), demonstrate increased insulin sensitivity, suggesting that pharmacological inhibition of SHIP2 could alleviate ..
  50. pmc Brief calorie restriction increases Akt2 phosphorylation in insulin-stimulated rat skeletal muscle
    Carrie E McCurdy
    Department of Kinesiology, University of Wisconsin, 2000 Observatory Drive, Madison, WI 53706, USA
    Am J Physiol Endocrinol Metab 285:E693-700. 2003
    ..We also assessed changes in the abundance of SH2 domain-containing inositol phosphatase (SHIP2), a negative regulator of insulin signaling...
  51. pmc Serum withdrawal-induced accumulation of phosphoinositide 3-kinase lipids in differentiating 3T3-L6 myoblasts: distinct roles for Ship2 and PTEN
    Adel Mandl
    Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA
    Mol Cell Biol 27:8098-112. 2007
    ..Knockdown of the lipid phosphatase Ship2, on the other hand, dramatically increased the steady-state levels of PI-3,4,5-P3 but did not affect Akt ..
  52. doi Multiple defects in negative regulation of the PKB/Akt pathway sensitise human cancer cells to the antiproliferative effect of non-steroidal anti-inflammatory drugs
    Eva Lincová
    Department of Cytokinetics, Institute of Biophysics, AS CR, Brno, Czech Republic
    Biochem Pharmacol 78:561-72. 2009
    ..cancer cell line LNCaP, lacking both critical enzymes in the negative control of PKB/Akt activation, PTEN and SHIP2, was the most sensitive to these effects, as assessed by analysing the cell cycle profile and expression of cell ..
  53. doi PTEN and SHIP2 regulates PI3K/Akt pathway through focal adhesion kinase
    Amit Gupta
    Department of Biotechnology, National Institute of Pharmaceutical Education and Research NIPER, Sec 67, S A S Nagar, Punjab 160 062, India
    Mol Cell Endocrinol 309:55-62. 2009
    ..Here we report that PTEN and SHIP2, the phosphatases widely implicated as negative regulators of insulin signaling, to be responsible for ..
  54. ncbi PPAR-gamma inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1
    Karim Benkirane
    Clinical Institute of Health Research Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 290:H390-7. 2006
    ..initiation factor 4E-binding protein 1 (4E-BP1), as well as Src homology (SH) 2-containing inositol phosphatase 2 (SHIP2)...
  55. doi Tyrosine phosphorylation of SHIP promotes its proteasomal degradation
    Jens Ruschmann
    The Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
    Exp Hematol 38:392-402, 402.e1. 2010
    ..We sought to determine the mechanism(s) involved in its downregulation by BCR-ABL and by interleukin (IL)-4...
  56. pmc Novel phosphotyrosine targets of FGFR2IIIb signaling
    Yongde Luo
    IBT Proteomics and Nanotechnology Laboratory, Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, Texas 77030 3303, USA
    Cell Signal 21:1370-8. 2009
    ..activities of FGFR1 that included multi-substrate organizers FRS2alpha and IRS4, ERK2 and phosphatases SHP2 and SHIP2. It uniquely phosphorylated CDK2 and phosphatase PTPN18 on sites involved in the attenuation of cell proliferation,..
  57. ncbi Membrane localization of Src homology 2-containing inositol 5'-phosphatase 2 via Shc association is required for the negative regulation of insulin signaling in Rat1 fibroblasts overexpressing insulin receptors
    Hajime Ishihara
    First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Mol Endocrinol 16:2371-81. 2002
    Lipid phosphatase SHIP2 [Src homology 2 (SH2)-containing inositol 5'-phosphatase 2] has been shown to be a physiologically critical negative regulator of insulin signaling...
  58. doi INPPL1 is associated with the metabolic syndrome in men with Type 1 diabetes, but not with diabetic nephropathy
    M E Hyvönen
    Department of Pathology, University of Helsinki, Helsinki, Finland
    Diabet Med 29:1589-95. 2012
    ..of this study was to investigate if the INPPL1 (inositol polyphosphate phosphatase-like 1) gene encoding lipid phosphatase SHIP2 is associated with the metabolic syndrome and diabetic nephropathy in Finnish people with Type 1 diabetes.
  59. ncbi Role of inhibitory BCR co-receptors in immunity
    Takeshi Tsubata
    Laboratory of Immunology, Tokyo Medical and Dental University Graduate School of Biomedical Sciences, 1 5 45 Yushima, Bunkyo ku, 113 8510 Tokyo, Japan
    Infect Disord Drug Targets 12:181-90. 2012
    ..protein tyrosine phosphatase 1 (SHP-1), SHP-2, SH2 domain- containing inositol 5-phosphatase 1 (SHIP1) and SHIP2 depending on receptors. These phosphatases then negatively regulate B cell antigen receptor (BCR) signaling...
  60. doi Phosphotyrosine mediated protein interactions of the discoidin domain receptor 1
    Simone Lemeer
    Chair of Proteomics and Bioanalytics, Technische Universitat Munchen, Emil Erlenmeyer Forum 5, 85354 Freising, Germany
    J Proteomics 75:3465-77. 2012
    ..numerous signaling proteins as new putative phosphotyrosine mediated interactors including RasGAP, SHIP1, SHIP2, STATs, PI3K and the SRC family kinases...
  61. doi Inositol polyphosphate phosphatases in human disease
    Sandra Hakim
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Rd, Clayton 3800, Australia
    Curr Top Microbiol Immunol 362:247-314. 2012
    ..Additionally, polymorphisms in the 5-phosphatase SHIP2 confer diabetes susceptibility in specific populations, whereas reduced protein expression of SHIP1 is reported in ..
  62. pmc Heterotypic Sam-Sam association between Odin-Sam1 and Arap3-Sam: binding affinity and structural insights
    Flavia A Mercurio
    Department of Biological Sciences, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy
    Chembiochem 14:100-6. 2013
    ..Both Arap3-Sam and EphA2-Sam are able to associate with the Sam domain of the lipid phosphatase Ship2 (Ship2-Sam)...
  63. pmc Elevated expression of SHIP2 correlates with poor prognosis in non-small cell lung cancer
    Maoying Fu
    Department of Infectious Diseases, The First People s Hospital of Kunshan Affiliated with Jiangsu University Suzhou 215000, China
    Int J Clin Exp Pathol 6:2185-91. 2013
    SH2-containing inositol 5'-phosphatase 2 (SHIP2) is a vital regulator of phosphoinositide pools in metabolic pathways and is considered to downregulate phosphatidylinositol 3'-kinase signaling, which underlies the development of several ..
  64. doi Reversible Ser/Thr SHIP phosphorylation: a new paradigm in phosphoinositide signalling?: Targeting of SHIP1/2 phosphatases may be controlled by phosphorylation on Ser and Thr residues
    William s Elong Edimo
    Institut de Recherche Interdisciplinaire IRIBHM, Universite Libre de Bruxelles, Campus Erasme, Brussels, Belgium
    Bioessays 34:634-42. 2012
    ..Since a subunit of the Ser/Thr phosphatase PP2A has been shown to interact with SHIP2, a putative mechanism for reversing SHIP2 Ser/Thr phosphorylation can be anticipated...
  65. pmc SHIP2 regulates epithelial cell polarity through its lipid product, which binds to Dlg1, a pathway subverted by hepatitis C virus core protein
    Aline Awad
    Universite Paris Sud, UMR S 785, F 94800 Villejuif, France
    Mol Biol Cell 24:2171-85. 2013
    ..This is associated with decreased expression of the polarity protein Dlg1 and the PI phosphatase SHIP2, which converts phosphatidylinositol 3,4,5-trisphosphate into phosphatidylinositol 4,5-bisphosphate (PtdIns(3,4)P2)..
  66. ncbi Regulation of phosphoinositide signaling by the inositol polyphosphate 5-phosphatases
    Megan V Astle
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    IUBMB Life 58:451-6. 2006
    ..we highlight recently established insights into the functions of two well characterized 5-phosphatases OCRL and SHIP2, which have been the subject of extensive functional studies, and the characterization of recently identified ..
  67. ncbi Localization of mRNA for SHIP2, SH2 domain-containing inositol polyphosphate 5-phosphatase, in the brain of developing and mature rats
    M Kudo
    Division of Histology, Department of Cell Biology, Graduate School of Medical Science, Tohoku University, 2 1, Seiryo machi, Aoba ku, Sendai, Japan
    Brain Res Mol Brain Res 75:172-7. 2000
    The localization of mRNA for SHIP2, SH2 domain containing inositol 5-phosphatase SHIP isozyme, was examined by in situ hybridization histochemistry in the brain of developing and mature rats...
  68. pmc SHIP2, a factor associated with diet-induced obesity and insulin sensitivity, attenuates FGF signaling in vivo
    Michael J Jurynec
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Dis Model Mech 3:733-42. 2010
    SH2-domain-containing inositol phosphatase 2 (SHIP2) belongs to a small family of phosphoinositide 5-phosphatases that help terminate intracellular signaling initiated by activated receptor tyrosine kinases...
  69. doi Despite identifying some shared gene associations with human atopic dermatitis the use of multiple dog breeds from various locations limits detection of gene associations in canine atopic dermatitis
    Shona H Wood
    Department of Comparative Molecular Medicine, School of Veterinary Science, The University of Liverpool, Liverpool, UK
    Vet Immunol Immunopathol 138:193-7. 2010
    ..This study therefore suggests that further candidate gene studies in cAD should be breed and location specific to increase the likelihood of finding associations with the disease...
  70. pmc Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells
    Nai Ying Yang
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Cell Signal 23:201-12. 2011
    ..changes in the activity of Akt upstream regulators (such as Ras family GTPases, PI3 kinase, integrins, or the Ship2 lipid phosphatase) in the observed loss of Akt T308 and S473 phosphorylation downstream of EphA2...
  71. doi Impact of lipid phosphatases SHIP2 and PTEN on the time- and Akt-isoform-specific amelioration of TNF-alpha-induced insulin resistance in 3T3-L1 adipocytes
    Mariko Ikubo
    Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Am J Physiol Endocrinol Metab 296:E157-64. 2009
    ..Since lipid phosphatases SH2-containing inositol 5'-phoshatase 2 (SHIP2) and phosphatase and tensin homologs deleted on chromosome 10 (PTEN) are negative regulators of insulin's ..
  72. pmc MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia
    Jia Yu
    Department of Dermatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 105:19300-5. 2008
    ..Here we demonstrate not only that the lipid phosphatase SHIP2 is a target of miRNA-205 (miR-205) in epithelial cells, but, more importantly, that the corneal epithelial-..
  73. pmc MicroRNA-205 promotes keratinocyte migration via the lipid phosphatase SHIP2
    Jia Yu
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Ave, Ward 9 124, Chicago, IL 60611, USA
    FASEB J 24:3950-9. 2010
    microRNA-205 (miR-205) and miR-184 coordinately regulate the lipid phosphatase SHIP2 for Akt survival signaling in keratinocytes...
  74. ncbi SHIPs ahoy
    G Krystal
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, Canada
    Int J Biochem Cell Biol 31:1007-10. 1999
    ..More recently, a second more widely expressed SHIP-like protein has been cloned and called SHIP2. Both specifically hydrolyze phosphatidylinositol-3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in ..
  75. ncbi The mouse SHIP2 (Inppl1) gene: complementary DNA, genomic structure, promoter analysis, and gene expression in the embryo and adult mouse
    S Schurmans
    IRIBHN, Faculty of Medicine, Free University of Brussels, Belgium
    Genomics 62:260-71. 1999
    b>SHIP2 is a new member of the inositol polyphosphate 5-phosphatase family showing homology to SHIP1...
  76. pmc Hydrogen sulfide and L-cysteine increase phosphatidylinositol 3,4,5-trisphosphate (PIP3) and glucose utilization by inhibiting phosphatase and tensin homolog (PTEN) protein and activating phosphoinositide 3-kinase (PI3K)/serine/threonine protein kinase (A
    Prasenjit Manna
    Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    J Biol Chem 286:39848-59. 2011
    ..The PIP3 increase is mediated by PI3K activation and inhibition of PTEN but not of SHIP2. This study provides evidence for a molecular mechanism by which H(2)S or LC can up-regulate the insulin-signaling ..
  77. pmc 5-Stabilized phosphatidylinositol 3,4,5-trisphosphate analogues bind Grp1 PH, inhibit phosphoinositide phosphatases, and block neutrophil migration
    Honglu Zhang
    Department of Medicinal Chemistry, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, UT 84108 1257, USA
    Chembiochem 11:388-95. 2010
    ..Second, the enzymology of the five analogues is explored, showing the relative efficiency of inhibition of SHIP1, SHIP2, and phosphatase and tensin homologue deleted on chromosome 10 (PTEN), as well as the greatly reduced ability of ..
  78. doi The SH2 domains of inositol polyphosphate 5-phosphatases SHIP1 and SHIP2 have similar ligand specificity but different binding kinetics
    Yanyan Zhang
    Department of Chemistry and Ohio State Biochemistry Program, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA
    Biochemistry 48:11075-83. 2009
    SH2 domain-containing inositol 5-phosphatases 1 (SHIP1) and 2 (SHIP2) are structurally similar proteins that catalyze the degradation of lipid secondary messenger phosphatidylinositol 3,4,5-triphosphate to produce phosphatidylinositol 3,..
  79. pmc The Sam domain of the lipid phosphatase Ship2 adopts a common model to interact with Arap3-Sam and EphA2-Sam
    Marilisa Leone
    Burnham Institute for Medical Research, La Jolla, California, USA
    BMC Struct Biol 9:59. 2009
    ..Previous studies have demonstrated that the Sam domain of the lipid phosphatase Ship2 can hetero-dimerize with the Sam domain of the PI3K effector protein Arap3.
  80. doi Negative action of hepatocyte growth factor/c-Met system on angiotensin II signaling via ligand-dependent epithelial growth factor receptor degradation mechanism in vascular smooth muscle cells
    Fumihiro Sanada
    Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Yamada oka, Suita, Japan
    Circ Res 105:667-75, 13 p following 675. 2009
    ..Hepatocyte growth factor (HGF) is known as an antiinflammatory growth factor, although it is downregulated in injured tissue. However, the precise mechanism how HGF reduces inflammation is unclear...
  81. pmc Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2
    A Suwa
    Astellas Pharma Inc, Miyukigaoka, Tsukuba shi, Ibaraki, Japan
    Br J Pharmacol 158:879-87. 2009
    The lipid phosphatase known as SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) plays an important role in the regulation of the intracellular insulin signalling pathway...
  82. pmc Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodin
    Madhusudan Venkatareddy
    Division of Nephrology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e28710. 2011
    ..Upon activation Nephrin recruits and regulates a protein complex that includes Ship2 (SH2 domain containing 5' inositol phosphatase), Filamin and Lamellipodin, proteins important in regulation of ..
  83. doi Early signal protein expression profiles in basophils: a population study
    Susan Ishmael
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Leukoc Biol 86:313-25. 2009
    ..of syk, the variance of expression of 19 other elements (lyn, fyn, csk, cbp/PAG, CIN85, Bob1, c-cbl, SHIP1, SHIP2, p85alpha, p110delta, btk, PLCgamma1, PLCgamma2, SHP-1, PTEN, SOS2, CRACM1, and IL-3Ralpha) was narrow despite a ..
  84. pmc Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton
    Parvin Rahman
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    J Biol Chem 286:29758-70. 2011
    ..Several 5-ptases, including SKIP and SHIP2, inhibit actin cytoskeletal reorganization by opposing PI3K/Akt signaling...
  85. ncbi SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signaling
    Ruma A Pengal
    Molecular, Cellular, and Developmental Biology Program, Dorothy M Davis Heart and Lung Institute, James Cancer Hospital, Ohio State University, Columbus 43210, USA
    J Biol Chem 278:22657-63. 2003
    ..These findings unravel a novel level of regulation of FcgammaR-mediated activation of human myeloid cells by the expression and function of the inositol phosphatase SHIP-2...
  86. ncbi SHIP2 interaction with the cytoskeletal protein Vinexin
    Nathalie Paternotte
    Interdisciplinary Research Institute IRIBHM, Universite Libre de Bruxelles, Brussels, Belgium
    FEBS J 272:6052-66. 2005
    The src homology 2 (SH2) domain-containing inositol 5-phosphatase 2 (SHIP2) catalyses the dephosphorylation of phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P3] to phosphatidylinositol 3,4-bisphosphate [PtdIns(3,4)P2]...
  87. ncbi Differences in signaling pathways and expression level of the phosphoinositide phosphatase SHIP1 between two oncogenic mutants of the receptor tyrosine kinase KIT
    J M Vanderwinden
    Laboratoire de Neurophysiologie, Faculte de Medecine, Campus Erasme, CP 601, Universite Libre de Bruxelles, 808 Route de Lennik, B 1070 Brussels, Belgium
    Cell Signal 18:661-9. 2006
    ..Noteworthy, the protein level of the phosphoinositide phosphatase SHIP1, but not SHIP2 and PTEN, was reduced in KIT(K641E) only while inhibition of KIT phosphorylation reversibly raised SHIP1 level in ..
  88. ncbi Impact of the liver-specific expression of SHIP2 (SH2-containing inositol 5'-phosphatase 2) on insulin signaling and glucose metabolism in mice
    Kazuhito Fukui
    Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930 0194, Japan
    Diabetes 54:1958-67. 2005
    We investigated the role of hepatic SH2-containing inositol 5'-phosphatase 2 (SHIP2) in glucose metabolism in mice...
  89. ncbi Pi 3-kinase and its up- and down-stream modulators as potential targets for the treatment of type II diabetes
    Guoqiang Jiang
    Metabolic Disorders Diabetes, Merck Research Laboratories, RY80N C31, P O Box 2000, Rahway, NJ 07065, USA
    Front Biosci 7:d903-7. 2002
    ..These potential targets include Src homology 2 domain containing inositol 5-phosphatase 2 (SHIP2), phosphatase and tensin homolog deleted on chromosome ten (PTEN), kappaB kinase beta (IKKbeta), PKC isoforms, and ..
  90. ncbi The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man
    Evelyne Marion
    IRIBHM Institut de Recherches en Biologie Humaine et Moléculaire, IBMM Institut de Biologie et de Médecine Moléculaires, ULB Université Libre de Bruxelles, rue des Professeurs Jeener et Brachet 122, 6041 Gosselies, Belgium
    Diabetes 51:2012-7. 2002
    ..The lipid phosphatase SHIP2 is a potent negative regulator of insulin signaling and sensitivity in vivo and is thus a good candidate gene...
  91. ncbi Inhibition of endogenous SHIP2 ameliorates insulin resistance caused by chronic insulin treatment in 3T3-L1 adipocytes
    T Sasaoka
    Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Diabetologia 48:336-44. 2005
    b>SHIP2 is a physiologically important negative regulator of insulin signalling hydrolysing the PI3-kinase product, PI(3,4,5)P3, which also has an impact on insulin resistance...
  92. ncbi SHIP2 is recruited to the cell membrane upon macrophage colony-stimulating factor (M-CSF) stimulation and regulates M-CSF-induced signaling
    Yijie Wang
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, and The Dorothy M Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH 43210, USA
    J Immunol 173:6820-30. 2004
    ..In contrast to the limited cellular expression of SHIP1, the related isoform SHIP2, is widely expressed in both parenchymal and hemopoietic cells...
  93. ncbi SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase
    Michael G Tomlinson
    Department of Medicine and Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143, USA
    J Biol Chem 279:55089-96. 2004
    ..In this study, we show that the inositol 5' phosphatases SHIP1 and SHIP2 interact preferentially with Tec, compared with other Tec family members...
  94. ncbi Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap
    Isabelle Isnardi
    Laboratoire d Immunologie Cellulaire et Clinique, INSERM U255, Institut de Recherches biomédicales des Cordeliers, 75006 Paris, France
    J Biol Chem 279:51931-8. 2004
    ..tyrosyl-phosphorylated and recruit the Src homology 2 (SH2) domain-containing inositol 5'-phosphatases SHIP1 and SHIP2, which mediate inhibition. The FcgammaRIIB ITIM was proposed to be necessary and sufficient for recruiting SHIP1/2...
  95. ncbi The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2
    Isabelle Vandenbroere
    Institute of Interdisciplinary Research, IRIBHM, School of Medicine, Free University of Brussels, Campus Erasme, Blg C, Route de Lennik 808, Brussels B 1070, Belgium
    Biochem Biophys Res Commun 300:494-500. 2003
    b>SHIP2 is a phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) 5-phosphatase which contains motifs susceptible to mediate protein-protein interaction...
  96. ncbi Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome
    Pamela J Kaisaki
    The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Diabetes 53:1900-4. 2004
    Type II SH2 domain-containing inositol 5-phosphatase (INPPL1, or SHIP2) plays an important role in the control of insulin sensitivity...
  97. ncbi Src homology 2 domain-containing inositol polyphosphate phosphatase regulates NF-kappa B-mediated gene transcription by phagocytic Fc gamma Rs in human myeloid cells
    Susheela Tridandapani
    Department of Internal Medicine, Heart and Lung Research Institute, Room 405D, Ohio State University, 473 West Twelfth Avenue, Columbus, OH 43210, USA
    J Immunol 169:4370-8. 2002
    ..These findings both provide a molecular mechanism for SHIP association with native ITAM-bearing receptors and demonstrate that SHIP association with ITAM-FcgammaR serves to regulate gene expression during the phagocytic process...
  98. ncbi Impact of Src homology 2-containing inositol 5'-phosphatase 2 on the regulation of insulin signaling leading to protein synthesis in 3T3-L1 adipocytes cultured with excess amino acids
    Shihou Murakami
    Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Endocrinology 145:3215-23. 2004
    Src homology 2-containing inositol 5'-phosphatase 2 (SHIP2) possesses 5'-phosphatase activity to specifically hydrolyze the phosphatidylinositol 3-kinase product PI(3,4,5)P3 in the regulation of insulin signaling...
  99. ncbi Nonreceptor protein tyrosine and lipid phosphatases in type I fc(epsilon) receptor-mediated activation of mast cells and basophils
    Petr Heneberg
    Institute of Molecular Genetics, Academy of Science of the Czech Republic, Prague, Czech Republic
    Int Arch Allergy Immunol 128:253-63. 2002
    ..phosphatases (SHP-1, SHP-2, HePTP, PTP20, PRL1, PRL2, PTP-MEG1 and PTP-MEG2) and lipid phosphatases (SHIP and SHIP2) in the activation of mast cells and basophils after Fc(epsilon)RI aggregation...
  100. ncbi The insulin-sensitive side of SHIP2
    S Schurmans
    IRIBHN Institute of Interdisciplinary Research at IBMM Institute of Molecular Biology and Medicine, Gosselies, Belgium
    ScientificWorldJournal 1:209-10. 2001
    ..e., decreased insulin sensitivity). Beside type II diabetes, other diseases like obesity, hypertension, atherosclerosis, hyperlipidaemia, polycystic ovarian syndrome, and acromegaly are indeed associated with insulin resistance...

Research Grants59

  1. The Role of MicroRNAs in Corneal Epithelial Homeostasis
    Robert M Lavker; Fiscal Year: 2010
    ..We successfully identified the lipid phosphatase SHIP2 as one of the targets of miR-205 and observed that miR-205 functions to enhance cell survival and alter ..
  2. Mechanisms of Chemo/Radioresistance in Human Gliomas
    Eliot M Rosen; Fiscal Year: 2010
    ..We found that two SH2-containing inositol-5-phosphatases (SHIP1 and SHIP2) regulate glioma cell sensitivity to chemotherapeutics...
  3. Intracellular pathways of monocyte survival
    Clay B Marsh; Fiscal Year: 2010
    ..SHIP1 and SHIP2 negatively regulate M-CSF-induced Akt and NF-?B activation and cellular activation and survival...
  4. Intracellular pathways of monocyte survival
    Clay Marsh; Fiscal Year: 2009
    ..SHIP1 and SHIP2 negatively regulate M-CSF-induced Akt and NF-?B activation and cellular activation and survival...
  5. FACTORS THAT MODIFY INSULIN ACTION
    MARIA BUSE; Fiscal Year: 2006
    ..g. by SHIP2 or PTEN, or PI(3)K may be mistargeted...
  6. Identification of Signaling Targets of EphA2
    Sonja Schmidt; Fiscal Year: 2005
    ..proteins, including guanine nucleotide exchange factor Vav3, adaptor protein Nck2 and lipid phosphatase SHIP2. In this application, I propose to finish the screens and investigate the role of EphA2-interacting proteins, Vav3 ..
  7. The Role of PtdIns-5-P in Cell Function and Signaling
    LUCIA RAMEH PLANT; Fiscal Year: 2004
    ..of PIP4k II in cells attenuates the signal initiated by insulin by activating the phosphoinositide phosphatase Ship2, while disruption of the PIP4k lib gene in mice increases sensitivity to insulin, a phenotype that resembles Ship2 ..
  8. The Role of PtdIns-5-P in Cell Function and Signaling
    LUCIA RAMEH PLANT; Fiscal Year: 2007
    ..of PIP4k II in cells attenuates the signal initiated by insulin by activating the phosphoinositide phosphatase Ship2, while disruption of the PIP4k lib gene in mice increases sensitivity to insulin, a phenotype that resembles Ship2 ..
  9. SEARCH FOR SELECTIVE THERAPY OF CML
    Bayard Clarkson; Fiscal Year: 2007
    ..All of these proteins have now been identified, including 3 novel proteins p62dok-1, p56dok-2, and SHIP2. The protein-protein and protein-phospholipid interactions involved in recognizing and initiating specific signals ..
  10. LIPID PHOSPHATASE ASSAYS IN DISEASE AND DRUG DISCOVERY
    BETH DREES; Fiscal Year: 2002
    ..These assays will be aimed at measuring the activity of the lipid phosphatases PTEN, SHIP1, and SHIP2, which modulate phosphoinositide 3-kinase signaling by conversion of Pl (3,4,5) P3 to Pl (4,5) P2 and Pl(3,4)P2 ..
  11. SHIP-2 influence on macrophage Fc receptor function
    Susheela Tridandapani; Fiscal Year: 2009
    ..The proposed work holds promise for a better understanding of the IC-mediated inflammatory diseases at the molecular level, and paves the way for novel therapeutic targets. ..
  12. REGULATION OF SECRETION FROM HUMAN BASOPHILS
    Donald MacGlashan; Fiscal Year: 2009
    ..A population of subjects will be examined for this relationship. ..
  13. MECHANISMS OF HUMAN BASOPHIL & MAST CELL DESENSITIZATION
    Donald MacGlashan; Fiscal Year: 1993
    ..Since cytokine release appears dependent on mRNA accumulation, initial studies will focus on the mechanisms of mRNA accumulation...
  14. REGULATION OF SECRETION FROM HUMAN BASOPHILS
    Donald MacGlashan; Fiscal Year: 2007
    ..A population of subjects will be examined for this relationship. ..
  15. MECHANISMS OF HUMAN BASOPHIL & MAST CELL DESENSITIZATION
    Donald MacGlashan; Fiscal Year: 1992
    ..Phosphorylation of 5'- phosphomonoesterase will be directly examined as will its activity in desensitized basophils and mast cells...
  16. Indentification of AKT2/aPKC Substrates in Adipocytes
    Prem Sharma; Fiscal Year: 2005
    ..We believe that the findings from the proposed investigations will improve our general understanding of players of insulin resistance and offer potential insight into new therapeutic modalities. ..
  17. REGULATION OF SECRETION FROM HUMAN BASOPHILS
    Donald MacGlashan; Fiscal Year: 2003
    ..Since cytokine release appears dependent on mRNA accumulation, initial studies will focus on the mechanisms of mRNA accumulation. ..