SHIP

Summary

Gene Symbol: SHIP
Description: inositol polyphosphate-5-phosphatase D
Alias: SHIP, SHIP-1, SHIP1, SIP-145, hp51CN, p150Ship, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, SH2 domain-containing inositol 5'-phosphatase 1, inositol polyphosphate-5-phosphatase, 145kD, inositol polyphosphate-5-phosphatase, 145kDa, signaling inositol polyphosphate 5 phosphatase SIP-145, signaling inositol polyphosphate phosphatase SHIP II
Species: human
Products:     SHIP

Top Publications

  1. Mason J, Beattie B, Liu Q, Dumont D, Barber D. The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor. J Biol Chem. 2000;275:4398-406 pubmed
    b>Ship1 (SH2 inositol 5-phosphatase 1) has been shown to be a target of tyrosine phosphorylation downstream of cytokine and immunoregulatory receptors...
  2. Lee D, Futami M, Carroll M, Feng Y, Wang Z, Fernandez M, et al. Loss of SHIP-1 protein expression in high-risk myelodysplastic syndromes is associated with miR-210 and miR-155. Oncogene. 2012;31:4085-94 pubmed publisher
    ..In turn, the phosphoinositides are dephosphorylated by two lipid phosphatases, PTEN and SHIP-1, in myeloid cells...
  3. Cremer T, Ravneberg D, Clay C, Piper Hunter M, Marsh C, Elton T, et al. MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response. PLoS ONE. 2009;4:e8508 pubmed publisher
    ..Previous work from our laboratory identified the PI3K/Akt pathway and SHIP as critical modulators of host resistance to Francisella...
  4. Koch A, Mancini A, El Bounkari O, Tamura T. The SH2-domian-containing inositol 5-phosphatase (SHIP)-2 binds to c-Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading. Oncogene. 2005;24:3436-47 pubmed
    ..In this paper, we show for the first time that the SH2-domain-containing inositol 5-phosphatase (SHIP)-2 binds directly to the hepatocyte growth factor (HGF/SF) receptor, c-Met, via phosphotyrosine 1356...
  5. Lioubin M, Algate P, Tsai S, Carlberg K, Aebersold A, Rohrschneider L. p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity. Genes Dev. 1996;10:1084-95 pubmed
    ..Ectopic expression of p150 in fibroblasts does not inhibit growth. This novel protein, p150(ship) (SH2-containing inositol phosphatase), identifies a component of a new growth factor-receptor signaling pathway in ..
  6. Kavanaugh W, Pot D, Chin S, Deuter Reinhard M, Jefferson A, Norris F, et al. Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2. Curr Biol. 1996;6:438-45 pubmed
    ..Furthermore, SIP-110, SIP-130 and SIP-145 prefer 3-phosphorylated substrates, suggesting a link to the phosphatidylinositol 3-kinase signaling pathway. ..
  7. Wisniewski D, Strife A, Swendeman S, Erdjument Bromage H, Geromanos S, Kavanaugh W, et al. A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells. Blood. 1999;93:2707-20 pubmed
    ..In addition to an N-terminal SH2 domain and a central catalytic region, SHIP2 (like SHIP1) possesses both potential PTB(NPXY) and SH3 domain (PXXP) binding motifs...
  8. Dunant N, Wisniewski D, Strife A, Clarkson B, Resh M. The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells. Cell Signal. 2000;12:317-26 pubmed
    ..formation between endogenous Dok1 and the SH2 domain-containing phosphatidylinositol polyphosphate 5-phosphatase SHIP1 in hematopoietic cells expressing Bcr-Abl...
  9. Damen J, Liu L, Rosten P, Humphries R, Jefferson A, Majerus P, et al. The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proc Natl Acad Sci U S A. 1996;93:1689-93 pubmed
    ..This novel signal transduction intermediate may serve to modulate both Ras and inositol signaling pathways. Based on its properties, we suggest the 145-kDa protein be called SHIP for SH2-containing inositol phosphatase.

More Information

Publications135 found, 100 shown here

  1. Galandrini R, Tassi I, Mattia G, Lenti L, Piccoli M, Frati L, et al. SH2-containing inositol phosphatase (SHIP-1) transiently translocates to raft domains and modulates CD16-mediated cytotoxicity in human NK cells. Blood. 2002;100:4581-9 pubmed
    Membrane recruitment of the SH2-containing 5' inositol phosphatase 1 (SHIP-1) is responsible for the inhibitory signals that modulate phosphatidylinositol 3-kinase (PI3K)-dependent signaling pathways...
  2. Kaushansky A, Kaushansky K. Systems biology of megakaryocytes. Adv Exp Med Biol. 2014;844:59-84 pubmed publisher
    ..proteins; phosphoinositol-3-kinase; mitogen-activated protein kinases; the phosphatases PTEN, SHP1, SHP2, and SHIP1; and the suppressors of cytokine signaling (SOCS) proteins...
  3. Wang W, Tang Y, Wang Y, Tascau L, Balcerek J, Tong W, et al. LNK/SH2B3 Loss of Function Promotes Atherosclerosis and Thrombosis. Circ Res. 2016;119:e91-e103 pubmed publisher
    ..myeloproliferative leukemia virus oncogene signaling and AKT activation, whereas cholesterol loading decreases SHIP-1 phosphorylation, acting convergently to increase AKT and platelet activation...
  4. Zhuang Z, Xiao qin -, Hu H, Tian S, Lu Z, Zhang T, et al. Down-regulation of microRNA-155 attenuates retinal neovascularization via the PI3K/Akt pathway. Mol Vis. 2015;21:1173-84 pubmed
    ..The expression levels of SHIP1 and p-Akt (Thr308, Ser473, and Thr450) were evaluated both in vitro and in vivo...
  5. Malbec O, Cassard L, Albanesi M, Jönsson F, Mancardi D, Chicanne G, et al. Trans-inhibition of activation and proliferation signals by Fc receptors in mast cells and basophils. Sci Signal. 2016;9:ra126 pubmed publisher
    ..by receptors, whether inhibitory (FcγRIIB) or activating (FcεRI), which recruited the lipid phosphatase SHIP1. By hydrolyzing PI(3,4,5)P3, SHIP1 induced a global unresponsiveness that affected biological responses ..
  6. Kovendhan M, Kang H, Jeong S, Youn J, Oh I, Park Y, et al. Study of stainless steel electrodes after electrochemical analysis in sea water condition. Environ Res. 2019;173:549-555 pubmed publisher
    ..has good mechanical properties and durability so it is widely used in desalination plants, oil and gas industries, ship building, etc. However, over a period of time it corrodes very quickly in saline water...
  7. Flach C, Pal C, Svensson C, Kristiansson E, Ostman M, Bengtsson Palme J, et al. Does antifouling paint select for antibiotic resistance?. Sci Total Environ. 2017;590-591:461-468 pubmed publisher
    ..Most antifouling paints contain high amounts of such substances, which risks turning painted ship hulls into highly mobile refuges and breeding grounds for antibiotic-resistant bacteria...
  8. Piontek U, Wallaschofski H, Kastenmüller G, Suhre K, Volzke H, Do K, et al. Sex-specific metabolic profiles of androgens and its main binding protein SHBG in a middle aged population without diabetes. Sci Rep. 2017;7:2235 pubmed publisher
    ..women, aged 20-80 years, who were recruited for the cross-sectional population-based Study of Health in Pomerania (SHIP-TREND), Germany...
  9. Cojohari O, Peppenelli M, Chan G. Human Cytomegalovirus Induces an Atypical Activation of Akt To Stimulate the Survival of Short-Lived Monocytes. J Virol. 2016;90:6443-6452 pubmed publisher
    ..in contrast to M-CSF, HCMV promoted a rapid increase in SH2 domain-containing inositol 5-phosphatase 1 (SHIP1) expression, leading to signaling through a noncanonical Akt activation pathway...
  10. Pena Philippides J, Caballero Garrido E, Lordkipanidze T, Roitbak T. In vivo inhibition of miR-155 significantly alters post-stroke inflammatory response. J Neuroinflammation. 2016;13:287 pubmed
    ..These temporal changes correlated with altered expression of miR-155 target proteins SOCS-1, SHIP-1, and C/EBP-β and phosphorylation levels of cytokine signaling regulator STAT-3...
  11. Pinto S, Nirujogi R, Rojas P, Patil A, Manda S, Subbannayya Y, et al. Quantitative phosphoproteomic analysis of IL-33-mediated signaling. Proteomics. 2015;15:532-44 pubmed publisher
    ..All MS data have been deposited in the ProteomeXchange with identifier PXD000984 (http://proteomecentral.proteomexchange.org/dataset/PXD000984). ..
  12. Palazzo P, Alexandrov A, Alexandrov A. Do billing codes accurately capture intravenous tissue plasminogen activator treatment rates? Justified concern for clinical performance measures based on billing code assignment. J Stroke Cerebrovasc Dis. 2015;24:327-9 pubmed publisher
    ..Confirmed stroke registry IV tPA cases were retrieved from 2009 to 2011; tPA drip and ship cases were eliminated from the analysis...
  13. Oziolor E, Dubansky B, Burggren W, Matson C. Cross-resistance in Gulf killifish (Fundulus grandis) populations resistant to dioxin-like compounds. Aquat Toxicol. 2016;175:222-31 pubmed publisher
    The Houston Ship Channel (HSC) in Houston, Texas is an aquatic environment with a long history of contamination, including polychlorinated dibenzodioxins (PCDD), polychlorinated dibenzofurans (PCDF), polychlorinated biphenyls (PCBs), ..
  14. Matozzo V, Ercolini C, Serracca L, Battistini R, Rossini I, Granato G, et al. Assessing the health status of farmed mussels (Mytilus galloprovincialis) through histological, microbiological and biomarker analyses. J Invertebr Pathol. 2018;153:165-179 pubmed publisher
    ..there has been increased concern over environmental disturbances caused by anthropogenic activities such as ship traffic and dredging and the effects they have on the health of farmed mussels...
  15. Janowitz D, Habes M, Toledo J, Hannemann A, Frenzel S, Terock J, et al. Inflammatory markers and imaging patterns of advanced brain aging in the general population. Brain Imaging Behav. 2019;: pubmed publisher
    ..We analyzed magnetic resonance imaging (MRI) scans of 2204 participants from the Study of Health in Pomerania-2 (SHIP-2) and SHIP-Trend (55.6% women, mean age 52.4±13.7 years)...
  16. Campbell P, Zhang Y, Yan F, Lu Z, Streets D. Impacts of transportation sector emissions on future U.S. air quality in a changing climate. Part I: Projected emissions, simulation design, and model evaluation. Environ Pollut. 2018;238:903-917 pubmed publisher
    ..includes 1) transportation emission projections (including on-road vehicles, non-road engines, aircraft, rail, and ship) derived from a dynamic technology model that accounts for various technology and policy options under an IPCC ..
  17. Drobek A, Kralova J, Skopcova T, Kucova M, Novák P, Angelisová P, et al. PSTPIP2, a Protein Associated with Autoinflammatory Disease, Interacts with Inhibitory Enzymes SHIP1 and Csk. J Immunol. 2015;195:3416-26 pubmed publisher
    ..In this article, we show that PSTPIP2 binds the inhibitory enzymes Csk and SHIP1. The interaction with SHIP1 is of particular importance because it binds to the critical tyrosine residues at the ..
  18. Relova D, Ríos L, Acevedo A, Coronado L, Perera C, Pérez L. Impact of RNA Degradation on Viral Diagnosis: An Understated but Essential Step for the Successful Establishment of a Diagnosis Network. Vet Sci. 2018;5: pubmed publisher
    ..Moreover, the requirement to ship on dry ice could be hampered by high costs, particularly in underdeveloped countries or regions located far from ..
  19. Peyronnet B, Brucker B, Michel M. Lower Urinary Tract Symptoms: What's New in Medical Treatment?. Eur Urol Focus. 2018;4:17-24 pubmed publisher
    ..Other phase 3 trials are ongoing in bladder pain syndrome (AQX 11-25, a SHIP-1 activator) and in neurogenic detrusor overactivity (mirabegron and abobotulinum toxin A)...
  20. Asselmann E, Kische H, Haring R, Hertel J, Schmidt C, Nauck M, et al. Prospective associations of androgens and sex hormone-binding globulin with 12-month, lifetime and incident anxiety and depressive disorders in men and women from the general population. J Affect Disord. 2019;245:905-911 pubmed publisher
    ..We used data of n = 993 men and n = 980 women from the Study of Health in Pomerania (SHIP, a prospective-longitudinal general population study from northeastern Germany)...
  21. Karsten C, Pandey M, Figge J, Kilchenstein R, Taylor P, Rosas M, et al. Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1. Nat Med. 2012;18:1401-6 pubmed
    ..with dectin-1, resulting in phosphorylation of Src homology 2 domain–containing inositol phosphatase (SHIP) downstream of FcγRIIB and spleen tyrosine kinase downstream of dectin-1...
  22. Markert M, Trautmann T, Krause F, Cioaga M, Mouriot S, Wetzel M, et al. A new telemetry-based system for assessing cardiovascular function in group-housed large animals. Taking the 3Rs to a new level with the evaluation of remote measurement via cloud data transmission. J Pharmacol Toxicol Methods. 2018;93:90-97 pubmed publisher
    ..For the first time it is technically feasible to conduct a CV safety pharmacology study in Cynomolgus monkeys without having to ship them long distances to the home laboratory.
  23. Iwai L, Payne L, Luczynski M, Chang F, Xu H, Clinton R, et al. Phosphoproteomics of collagen receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung cancer mutants. Biochem J. 2013;454:501-13 pubmed publisher
    ..protein tyrosine phosphatase 2), NCK1 (non-catalytic region of tyrosine kinase adaptor protein 1), LYN, SHIP-2 [SH2 (Src homology 2)-domain-containing inositol phosphatase 2], PIK3C2A (phosphatidylinositol-4-phosphate 3-..
  24. Romagnoli P, Balducci C, Perilli M, Perreca E, Cecinato A. Particulate PAHs and n-alkanes in the air over Southern and Eastern Mediterranean Sea. Chemosphere. 2016;159:516-525 pubmed publisher
    ..in the marine atmosphere of Southern and Eastern Mediterranean Sea, in the frame of the scientific cruise of Urania ship between 27 July and 11 August 2013...
  25. Jensen S, Tadlock M, Douglas T, Provencher M, Ignacio R. Integration of Surgical Residency Training With US Military Humanitarian Missions. J Surg Educ. 2015;72:898-903 pubmed publisher
    To describe how the US Navy integrates surgical resident training during hospital ship-based humanitarian activities and discuss the potential operative and educational benefits during these missions...
  26. Ramos A, Elong Edimo W, Erneux C. Phosphoinositide 5-phosphatase activities control cell motility in glioblastoma: Two phosphoinositides PI(4,5)P2 and PI(3,4)P2 are involved. Adv Biol Regul. 2018;67:40-48 pubmed publisher
    ..Two other PIs, PI(4,5)P2 and PI(3,4)P2, are produced or used as substrates of PI 5-phosphatases (OCRL, INPP5B, SHIP1/2, SYNJ1/2, INPP5K, INPP5J, INPP5E)...
  27. Castillo E, Leon J, Mazzei G, Abolhassani N, Haruyama N, Saito T, et al. Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation. Sci Rep. 2017;7:17762 pubmed publisher
    ..These results suggest a strong correlation between cortical A? amyloidosis and the neuroinflammatory response and provide a better understanding of the involvement of gender effects in the development of AD. ..
  28. Markus M, Werner N, Schipf S, Siewert Markus U, Bahls M, Baumeister S, et al. Changes in Body Weight and Composition Are Associated With Changes in Left Ventricular Geometry and Function in the General Population: SHIP (Study of Health in Pomerania). Circ Cardiovasc Imaging. 2017;10:e005544 pubmed publisher
    ..694 women), aged 44 to 86 years, from the baseline and the 5-year follow-up examination of the population-based SHIP (Study of Health in Pomerania)...
  29. Park G, Lee D, Treffiletti A, Hrsak M, Shugart J, Vinjé J. Evaluation of a New Environmental Sampling Protocol for Detection of Human Norovirus on Inanimate Surfaces. Appl Environ Microbiol. 2015;81:5987-92 pubmed publisher
    ..We used macrofoam swabs to collect environmental samples from several case cabins and common areas of a cruise ship where passengers had reported viral gastroenteritis symptoms. Seventeen (18...
  30. Dwivedi R, Priyaja P, Rafeeq M, Sudhakar M. MODIS-Aqua detects Noctiluca scintillans and hotspots in the central Arabian Sea. Environ Monit Assess. 2016;188:50 pubmed publisher
    ..This observation was substantiated with relevant oceanic parameters measured from the ship as well as satellite data and the same is highlight of the paper...
  31. Hong S, Lee J, Lim S. Navigational threats by derelict fishing gear to navy ships in the Korean seas. Mar Pollut Bull. 2017;119:100-105 pubmed publisher
    ..The frequency of cases was 2.3 per ship and 397.7 (±37.5) per year. The amount of DFG disentangled was 0.025tons per ship and 10.0 (±1.7) tons per year...
  32. Pauls S, Marshall A. Regulation of immune cell signaling by SHIP1: A phosphatase, scaffold protein, and potential therapeutic target. Eur J Immunol. 2017;47:932-945 pubmed publisher
    The phosphoinositide phosphatase SHIP is a critical regulator of immune cell activation. Despite considerable study, the mechanisms controlling SHIP activity to ensure balanced cell activation remain incompletely understood...
  33. Bian M, Du X, Wang P, Cui J, Xu J, Gu J, et al. Combination of ginsenoside Rb1 and Rd protects the retina against bright light-induced degeneration. Sci Rep. 2017;7:6015 pubmed publisher
    ..or Rd also modulated the expression of proinflammatory microRNA, miR-155 and its direct target, anti-inflammatory SHIP1, in LPS-stimulated RAW264.7 cells...
  34. Liu S, Yu J, Sanchez R, Liu X, Heidt D, Willey J, et al. A novel synthetic human insulin super promoter for targeting PDX-1-expressing pancreatic cancer. Cancer Lett. 2018;418:75-83 pubmed publisher
    ..Reporter assay demonstrated that SHIP1 was the most powerful promoter among all of the SHIPs and had far greater activity than the endogenous human ..
  35. Halupa A, Chohan M, Stickle N, Beattie B, Miller B, Barber D. Erythropoietin receptor Y479 couples to ERK1/2 activation via recruitment of phospholipase Cgamma. Exp Cell Res. 2005;309:1-11 pubmed
    ..Hence, we have identified a novel adapter function for PLCgamma1 in EPO signaling in which recruitment of PLCgamma1 to EPO-R may lead to activation of the ERK pathway. ..
  36. Yee E, Hook J, Bhadbhade M, Vittorio O, Kuchel R, Brandl M, et al. Preparation, characterization and in vitro biological evaluation of (1:2) phenoxodiol-?-cyclodextrin complex. Carbohydr Polym. 2017;165:444-454 pubmed publisher
    ..motion of phenoxodiol within the cavity of ?-cyclodextrin while the X-ray crystal data displays by far the best 'ship-in-a-bottle' case of 1:2 inclusion complex...
  37. Shirmohammadi F, Lovett C, Sowlat M, Mousavi A, Verma V, Shafer M, et al. Chemical composition and redox activity of PM0.25 near Los Angeles International Airport and comparisons to an urban traffic site. Sci Total Environ. 2018;610-611:1336-1346 pubmed publisher
    ..of PM: mobile sources (combined gasoline and diesel vehicles), wood smoke, vegetative detritus, road dust and ship emissions...
  38. Markus M, Ittermann T, Wittfeld K, Schipf S, Siewert Markus U, Bahls M, et al. Prediabetes is associated with lower brain gray matter volume in the general population. The Study of Health in Pomerania (SHIP). Nutr Metab Cardiovasc Dis. 2017;: pubmed publisher
    ..We investigated the associations of fasting (FG) and 2-h postload (2HG) plasma glucose from oral glucose tolerance test (OGTT) with gray (GMV) and white (WMV) matter volume...
  39. Oziolor E, Apell J, Winfield Z, Back J, Usenko S, Matson C. Polychlorinated biphenyl (PCB) contamination in Galveston Bay, Texas: Comparing concentrations and profiles in sediments, passive samplers, and fish. Environ Pollut. 2018;236:609-618 pubmed publisher
    The industrialized portion of the Houston Ship Channel (HSC) is heavily contaminated with anthropogenic contaminants, most prominent of which are the polychlorinated biphenyls (PCBs)...
  40. Kerr W. Inhibitor and activator: dual functions for SHIP in immunity and cancer. Ann N Y Acad Sci. 2011;1217:1-17 pubmed publisher
    b>SHIP1 is at the nexus of intracellular signaling pathways in immune cells that mediate bone marrow (BM) graft rejection, production of inflammatory and immunosuppressive cytokines, immunoregulatory cell formation, the BM niche that ..
  41. Yoon H, Kales S, Luo R, Lipkowitz S, Randazzo P. ARAP1 association with CIN85 affects epidermal growth factor receptor endocytic trafficking. Biol Cell. 2011;103:171-84 pubmed publisher
    ..We propose a model in which the ARAP1-CIN85 complex drives exit of EGF-EGFR-Cbl complex from a pre-early endosome into a pathway distinct from the early endosome/lysosome pathway. ..
  42. Taylor C. Medical emergency announcements on cruise ships: an audit of outcome. Int Marit Health. 2015;66:203-6 pubmed publisher
    ..announcement were prospectively collected during the audit periods, including subsequent means of transfer to the ship's medical centre and duration of medical intervention as indicators of clinical severity...
  43. Umezawa T, Hasegawa Y, Novita I, Suzuki J, Morozumi T, Nogata Y, et al. Design, Synthesis, and Antifouling Activity of Glucosamine-Based Isocyanides. Mar Drugs. 2017;15: pubmed publisher
    Biofouling, an undesirable accumulation of organisms on sea-immersed structures such as ship hulls and fishing nets, is a serious economic issue whose effects include oil wastage and clogged nets...
  44. Fernandez A, Sierra E, Diaz Delgado J, Sacchini S, Sánchez Paz Y, Suárez Santana C, et al. Deadly acute Decompression Sickness in Risso's dolphins. Sci Rep. 2017;7:13621 pubmed publisher
    ..Deadly systemic, inflammatory, infectious, or neoplastic diseases, ship collision, military sonar, fisheries interaction or other type of lethal inducing associated trauma were ruled out...
  45. Toz A, Koseoglu B. Trajectory prediction of oil spill with Pisces 2 around Bay of Izmir, Turkey. Mar Pollut Bull. 2018;126:215-227 pubmed publisher
    The purpose of this study is to determine the risky areas by simulating trajectory of ship based oil spill in Bay of Izmir. To get well informed about fate, this study makes the best possible use one trajectory model...
  46. Zbawicka M, Trucco M, Wenne R. Single nucleotide polymorphisms in native South American Atlantic coast populations of smooth shelled mussels: hybridization with invasive European Mytilus galloprovincialis. Genet Sel Evol. 2018;50:5 pubmed publisher
    ..that was introduced from Europe into the Puerto Madryn area in Argentina, presumably by accidental introduction via ship traffic. We confirm the occurrence of a native M...
  47. Ding Y, Cao C, Huang J, Song Y, Liu G, Wu L, et al. Origins and features of oil slicks in the Bohai Sea detected from satellite SAR images. Mar Pollut Bull. 2016;106:149-54 pubmed publisher
    ..Most oil slicks were detected along main ship routes rather than around seaports and oil exploitation platforms...
  48. Srivastava N, Iyer S, Sudan R, Youngs C, Engelman R, Howard K, et al. A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome. JCI Insight. 2016;1: pubmed
    ..Genetic and chemical inhibition of SH2-containing inositol 5' phosphatase 1 (SHIP1) has been associated with systemic expansion of immunoregulatory cells that promote a lean-body state; however, ..
  49. Rothchild A, Sissons J, Shafiani S, Plaisier C, Min D, Mai D, et al. MiR-155-regulated molecular network orchestrates cell fate in the innate and adaptive immune response to Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2016;113:E6172-E6181 pubmed
    ..MiR-155-induced cell survival is mediated through the SH2 domain-containing inositol 5-phosphatase 1 (SHIP1)/protein kinase B (Akt) pathway...
  50. Gerschenfeld G, Muresan I, Blanc R, Obadia M, Abrivard M, Piotin M, et al. Two Paradigms for Endovascular Thrombectomy After Intravenous Thrombolysis for Acute Ischemic Stroke. JAMA Neurol. 2017;74:549-556 pubmed publisher
    ..do not have on-site MT facilities, and most patients need to be transferred secondarily after IVT (drip and ship), which may have an effect on the neurologic outcome...
  51. Shechner M, Tas E. Ozone formation induced by the impact of reactive bromine and iodine species on photochemistry in a polluted marine environment. Environ Sci Technol. 2017;: pubmed publisher
    ..NOX-rich conditions are typical to the polluted MBL, near coastlines and ship plumes...
  52. Condé C, Rambout X, Lebrun M, Lecat A, Di Valentin E, Dequiedt F, et al. The inositol phosphatase SHIP-1 inhibits NOD2-induced NF-?B activation by disturbing the interaction of XIAP with RIP2. PLoS ONE. 2012;7:e41005 pubmed publisher
    b>SHIP-1 is an inositol phosphatase predominantly expressed in hematopoietic cells. Over the ten past years, SHIP-1 has been described as an important regulator of immune functions...
  53. Kim H, Kim Y, Han K, Kim J, Song C. Ozone production efficiency of a ship-plume: ITCT 2K2 case study. Chemosphere. 2016;143:17-23 pubmed publisher
    Ozone production efficiency (OPE) of ship plume was first evaluated in this study, based on ship-plume photochemical/dynamic model simulations and the ship-plume composition data measured during the ITCT 2K2 (Intercontinental Transport ..
  54. Park M, Lee J, Park T, Cho Y, Hong K, Park J, et al. Characteristics of the Drip-and-Ship Paradigm for Patients with Acute Ischemic Stroke in South Korea. J Stroke Cerebrovasc Dis. 2016;25:2678-2687 pubmed publisher
    Data on the drip-and-ship paradigm in Korea are limited. The present study aimed to evaluate the use of the drip-and-ship paradigm and the time delays and outcomes associated with the paradigm in Korea...
  55. Cusick K, Dale J, Little B, Biffinger J. Draft Genome Sequences of Four Alteromonas macleodii Strains Isolated from Copper Coupons and Grown Long-Term at Elevated Copper Levels. Genome Announc. 2016;4: pubmed publisher
    Alteromonas macleodii is a marine bacterium involved in the early stages of biofouling on ship hulls treated with copper as an antifouling agent. We report here the draft genome sequences of an A...
  56. Xue H, Hua L, Guo M, Luo J. SHIP1 is targeted by miR-155 in acute myeloid leukemia. Oncol Rep. 2014;32:2253-9 pubmed publisher
    The SH2 domain-containing inositol 5'-phosphatase 1 (SHIP1) has been implicated as a suppressor of hematopoietic transformation as its activity can inhibit the PI3K/Akt signaling pathway...
  57. Hammock B, Hobbs J, Slater S, Acuña S, Teh S. Contaminant and food limitation stress in an endangered estuarine fish. Sci Total Environ. 2015;532:316-26 pubmed publisher
    ..conditions of fish collected from five regions in the SFE were compared: Cache Slough, Sacramento River Deep Water Ship Channel, Confluence, Suisun Bay and Suisun Marsh...
  58. Alm T. Plant species introduced by foreigners according to folk tradition in Norway and some other European countries: xenophobic tales or not?. J Ethnobiol Ethnomed. 2015;11:72 pubmed publisher
    ..The spreading vectors assumed in folk tradition are correct and well documented, e.g. ship cargos (including goods and packing materials), which are responsible for introducing ballast plants and other ..
  59. Guilbaud J, Massé A, Wolff F, Jaouen P. Porous membranes for ballast water treatment from microalgae-rich seawater. Mar Pollut Bull. 2015;101:612-7 pubmed publisher
    ..Recovery of the membrane process represents about 76.6% and 62.7% of the annual cost for a cruise ship (5400 passengers) and liquefied natural gas (LNG) carrier (75,000 m3 of liquid natural gas), followed by the ..
  60. von Benda Beckmann A, Wensveen P, Kvadsheim P, Lam F, Miller P, Tyack P, et al. Assessing the Effectiveness of Ramp-Up During Sonar Operations Using Exposure Models. Adv Exp Med Biol. 2016;875:1197-203 pubmed publisher
    ..In this paper, we investigated the effect of sonar parameters (source level, pulse-repetition time, ship speed) on sound exposure by using a simple analytical model and highlight the mechanisms that limit the ..
  61. Meisel P, Kohlmann T, Nauck M, Biffar R, Kocher T. Effect of body shape and inflammation on tooth loss in men and women. Clin Oral Investig. 2017;21:183-190 pubmed publisher
    ..Data of 2746 participants from the Study of Health in Pomerania (SHIP) were analysed. Men and women were 1:1 matched, N = 344:344, in three age strata for waist-to-hip ratio...
  62. Okay O, Ozmen M, Güngördü A, Yilmaz A, Yakan S, Karacik B, et al. Heavy metal pollution in sediments and mussels: assessment by using pollution indices and metallothionein levels. Environ Monit Assess. 2016;188:352 pubmed publisher
    ..The results indicated a significant metal pollution caused by Cu, Pb, and Zn especially in shipyard and shipbreaking sites. Higher concentrations of MT were observed in the ship/breaking yard samples after the transplantation.
  63. Luo J, Feng X, Luo C, Wang Y, Li D, Shu Y, et al. 14,15-EET induces the infiltration and tumor-promoting function of neutrophils to trigger the growth of minimal dormant metastases. Oncotarget. 2016;7:43324-43336 pubmed publisher
    ..miR-155 in turn down-regulated the expression of SHIP1 and DET1, thus augmenting the activation of JNK and c-Jun...
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    ..comprehensive and detailed maps of ocean and coastal environments has been hindered by the high cost of operating ship- and aircraft-based sensors. While a number of groups (e.g...
  65. Moroni D, Pieri G, Tampucci M, Salvetti O. A proactive system for maritime environment monitoring. Mar Pollut Bull. 2016;102:316-22 pubmed publisher
    ..We propose an integrated and interoperable system able to monitor ship traffic and marine operators, using sensing capabilities from a variety of electronic sensors, along with geo-..
  66. Jing W, Zhang X, Sun W, Hou X, Yao Z, Zhu Y. CRISPR/CAS9-Mediated Genome Editing of miRNA-155 Inhibits Proinflammatory Cytokine Production by RAW264.7 Cells. Biomed Res Int. 2015;2015:326042 pubmed publisher
    ..While upregulating the Src homology-2 domain-containing inositol 5-phosphatase 1 (SHIP1), the miR-155 GKO line is severely impaired in producing proinflammatory cytokines but slightly increased in ..
  67. Devault D, Beilvert B, Winterton P. Ship breaking or scuttling? A review of environmental, economic and forensic issues for decision support. Environ Sci Pollut Res Int. 2017;24:25741-25774 pubmed publisher
    ..But, the management of obsolete ships is an acute problem, with most Ship Recycling Facilities (SRF) situated in developing countries...
  68. Leng X, Ji K, Zhou S, Xing X, Zou H. An Adaptive Ship Detection Scheme for Spaceborne SAR Imagery. Sensors (Basel). 2016;16: pubmed publisher
    With the rapid development of spaceborne synthetic aperture radar (SAR) and the increasing need of ship detection, research on adaptive ship detection in spaceborne SAR imagery is of great importance...
  69. Vrana B, Smedes F, Allan I, Rusina T, Okonski K, Hilscherova K, et al. Mobile dynamic passive sampling of trace organic compounds: Evaluation of sampler performance in the Danube River. Sci Total Environ. 2018;636:1597-1607 pubmed publisher
    ..The DPS device was deployed from a ship cruising downstream the Danube River to provide temporally and spatially integrated concentrations...
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    ..We have previously cloned a cDNA for the murine 150-kD protein, SHIP, and found that it encodes a unique signaling intermediate that binds the SHC PTB domain through at least one ..
  71. Huang W, Fang T, Luo L, Zhao L, Che F. A Damping Grid Strapdown Inertial Navigation System Based on a Kalman Filter for Ships in Polar Regions. Sensors (Basel). 2017;17: pubmed publisher
    ..The Kalman filter based on the grid SINS error model which applies to the ship is established in this paper...
  72. Ware M, Rosten P, Damen J, Liu L, Humphries R, Krystal G. Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation. Blood. 1996;88:2833-40 pubmed
    ..Based on its domains and enzymatic activity, we named this protein SHIP for SH2-containing inositol phosphatase (Damen et al, Proc Natl Acad Sci USA 93:1689, 1996)...
  73. Liu Q, Shalaby F, Jones J, Bouchard D, Dumont D. The SH2-containing inositol polyphosphate 5-phosphatase, ship, is expressed during hematopoiesis and spermatogenesis. Blood. 1998;91:2753-9 pubmed
    b>Ship is a recently identified SH2-containing inositol polyphosphate 5-phosphatase that has been implicated as an important signaling molecule in cell-culture systems...
  74. Jin H, Kim T, Choi J, Kim M, Cho Y, Nam K, et al. MicroRNA-155 as a proinflammatory regulator via SHIP-1 down-regulation in acute gouty arthritis. Arthritis Res Ther. 2014;16:R88 pubmed publisher
    ..fluid mononuclear cells (SFMCs) were cultured in vitro with MSU crystals, and gene expression (human miR-155 and SHIP-1) were assessed by real-time PCR...
  75. Huang L, Zhang Y, Xu C, Gu X, Niu L, Wang J, et al. Rictor positively regulates B cell receptor signaling by modulating actin reorganization via ezrin. PLoS Biol. 2017;15:e2001750 pubmed publisher
    ..Overall, our study provides a new pathway linking cell metablism to BCR activation, in which Rictor regulates BCR signaling via actin reorganization. ..
  76. Wan J, Wang Y, Cheng M, Engel B, Zhang W, Peng H. Assessment of debris inputs from land into the river in the Three Gorges Reservoir Area, China. Environ Sci Pollut Res Int. 2018;25:5539-5549 pubmed publisher
    Riverine debris in the Three Gorges Reservoir Area (TGRA) poses a threat to electricity generation, ship navigation, and water environment...
  77. March M, Lucas D, Aman M, Ravichandran K. p135 src homology 2 domain-containing inositol 5'-phosphatase (SHIPbeta ) isoform can substitute for p145 SHIP in fcgamma RIIB1-mediated inhibitory signaling in B cells. J Biol Chem. 2000;275:29960-7 pubmed
    The inositol 5'-phosphatase, SHIP (also referred to as SHIP-1 or SHIPalpha), is expressed in all cells of the hematopoietic lineage...
  78. Strassheim D, Kim J, Park J, Mitra S, Abraham E. Involvement of SHIP in TLR2-induced neutrophil activation and acute lung injury. J Immunol. 2005;174:8064-71 pubmed
    The SHIP converts phosphatidylinositol 3,4,5 triphosphate to phosphatidyl 3,4 biphosphate. SHIP has negative regulatory functions on PI3K-dependent signaling pathways, which occupy important roles in modulating neutrophil functions...
  79. Margraf S, Garner L, Wilson T, Brown M. A polymorphism in a phosphotyrosine signalling motif of CD229 (Ly9, SLAMF3) alters SH2 domain binding and T-cell activation. Immunology. 2015;146:392-400 pubmed publisher
    ..These findings identify potential mechanisms by which a single SNP can perturb fine-tuning in the immune system with significant functional consequences. ..
  80. Raitsos D, Brewin R, Zhan P, Dreano D, Pradhan Y, Nanninga G, et al. Sensing coral reef connectivity pathways from space. Sci Rep. 2017;7:9338 pubmed publisher
    ..satellite-derived biophysical observations, particle dispersion model simulations, genetic population data and ship-borne in situ profiles to assess reef connectivity in the Red Sea. We simulated long-term (>20 yrs...
  81. Bailey S, Rajakaruna H. Optimizing methods to estimate zooplankton concentration based on generalized patterns of patchiness inside ballast tanks and ballast water discharges. Ecol Evol. 2017;7:9689-9698 pubmed publisher
    Zooplankton populations are spatially heterogeneous in nature and inside ship ballast tanks. Sampling methods should take heterogeneity into account, particularly when estimating quantitative variables such as abundance or concentration...
  82. Bayliss D, Duff J, Stricker P, Walker K. Decision-Making in Prostate Cancer – Choosing Active Surveillance Over Other Treatment Options: A Literature Review. Urol Nurs. 2017;37:15-22 pubmed
    A literature review was done using the Cognitive-Social Health Information Processing (C-SHIP) framework to identify how and why men diagnosed with prostate cancer choose active surveillance over other treatment options...
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    ..These findings suggest that in addition to previously reported signal-transduction functions, Dab2 could also act as an adaptor protein that may regulate protein trafficking...
  84. Yang L, Luo J, Liu X, Wen S, Yang J, Zhang J. [Effects of SHIP gene mutation on cell cycle related proteins and phosphorylated Akt in K562 cells]. Zhonghua Xue Ye Xue Za Zhi. 2009;30:548-52 pubmed
    To investigate the effect of SHIP gene mutation on the cell cycle and its related gene expression in K562 cells. The recombined green fluorescent protein (GFP) containing FIV-SHIP gene was transfected into K562 cells...
  85. Khalife J, Radomska H, Santhanam R, Huang X, Neviani P, Saultz J, et al. Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia. Leukemia. 2015;29:1981-92 pubmed publisher
    ..This results in the upregulation of the miR-155 targets SHIP1, an inhibitor of the PI3K/Akt pathway, and PU...
  86. Tu W, Liu X, Dong H, Yu Y, Wang Y, Chen H. Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1: a meaningful and independent marker to predict stroke in the Chinese population. J Mol Neurosci. 2014;52:507-14 pubmed publisher
    ..05. The association of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (SHIP-1) with stroke (P < 0.001) was confirmed using ELISA in replication studies...
  87. Li L, Zhang J, Diao W, Wang D, Wei Y, Zhang C, et al. MicroRNA-155 and MicroRNA-21 promote the expansion of functional myeloid-derived suppressor cells. J Immunol. 2014;192:1034-43 pubmed publisher
    ..Furthermore, miR-155 and miR-21 showed a synergistic effect on MDSC induction via targeting SHIP-1 and phosphatase and tensin homolog, respectively, leading to STAT3 activation...
  88. Su P, Lv B, Tomy G, Xu J, Tian W, Hou C, et al. Occurrences, composition profiles and source identifications of polycyclic aromatic hydrocarbons (PAHs), polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in ship ballast sediments. Chemosphere. 2017;168:1422-1429 pubmed publisher
    ..aromatic hydrocarbons (PAHs), polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in ship ballast sediments...
  89. Protasov A, Bardeau J, Morozovskaya I, Boretska M, Cherniavska T, Petrus L, et al. New promising antifouling agent based on polymeric biocide polyhexamethylene guanidine molybdate. Environ Toxicol Chem. 2017;36:2543-2551 pubmed publisher
    ..Commercial ship paint was then modified by the addition of a low concentration of polymeric biocide 5% (w/w)...
  90. Wang J, Li B, Chen L, Li L. A Novel Detection Method for Underwater Moving Targets by Measuring Their ELF Emissions with Inductive Sensors. Sensors (Basel). 2017;17: pubmed publisher
    ..A proof of concept measurement is presented. The ELF emissions from a surface ship were detected by inductive electronic and magnetic sensors as the ship was leaving a harbor...
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    An ultrasonic antifouling treatment was applied to a 96,000 m3 class drill-ship to verify its feasibility through a sea-trial...
  92. Sui L, Li N, Liu Q, Zhang W, Wan T, Wang B, et al. IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes. Biochem Biophys Res Commun. 2004;319:920-8 pubmed
    ..IgSF13 was hyper-phosphorylated and associated with Src homology-2 domain-containing phosphatases SHP-1 and SHIP, but not SHP-2...