SH2D1A

Summary

Gene Symbol: SH2D1A
Description: SH2 domain containing 1A
Alias: DSHP, EBVS, IMD5, LYP, MTCP1, SAP, SAP/SH2D1A, XLP, XLPD, XLPD1, SH2 domain-containing protein 1A, Duncan disease SH2-protein, SLAM associated protein/SH2 domain protein 1A, SLAM-associated protein, T cell signal transduction molecule SAP, signaling lymphocyte activation molecule-associated protein, signaling lymphocytic activation molecule-associated protein
Species: human
Products:     SH2D1A

Top Publications

  1. Roda Navarro P, Mittelbrunn M, Ortega M, Howie D, Terhorst C, Sanchez Madrid F, et al. Dynamic redistribution of the activating 2B4/SAP complex at the cytotoxic NK cell immune synapse. J Immunol. 2004;173:3640-6 pubmed
    ..of 2B4 and the signaling adaptor molecule, signaling lymphocyte activation molecule-associated protein (SAP), to the cytotoxic NK-IS upon formation of conjugates between resting NK cells and EBV-infected 721.221 human cells...
  2. Poy F, Yaffe M, Sayos J, Saxena K, Morra M, Sumegi J, et al. Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. Mol Cell. 1999;4:555-61 pubmed
    b>SAP, the product of the gene mutated in X-linked lymphoproliferative syndrome (XLP), consists of a single SH2 domain that has been shown to bind the cytoplasmic tail of the lymphocyte coreceptor SLAM...
  3. Sharifi R, Sinclair J, Gilmour K, Arkwright P, Kinnon C, Thrasher A, et al. SAP mediates specific cytotoxic T-cell functions in X-linked lymphoproliferative disease. Blood. 2004;103:3821-7 pubmed
    ..The gene defective in XLP is SAP (signaling lymphocytic activation molecule [SLAM]-associated protein), an adaptor protein that mediates signals ..
  4. Benoit L, Wang X, Pabst H, Dutz J, Tan R. Defective NK cell activation in X-linked lymphoproliferative disease. J Immunol. 2000;165:3549-53 pubmed
    X-linked lymphoproliferative disease (XLP) is characterized by a selective immune deficiency to EBV...
  5. Shlapatska L, Mikhalap S, Berdova A, Zelensky O, Yun T, Nichols K, et al. CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A. J Immunol. 2001;166:5480-7 pubmed
    ..SHIP), the SH2-containing protein tyrosine phosphatase (SHP-2), and the adaptor protein SH2 domain protein 1A (SH2D1A/DSHP/SAP, also called Duncan's disease SH2-protein (DSHP) or SLAM-associated protein (SAP))...
  6. Schwartzberg P, Mueller K, Qi H, Cannons J. SLAM receptors and SAP influence lymphocyte interactions, development and function. Nat Rev Immunol. 2009;9:39-46 pubmed publisher
    Mutations that affect the adaptor molecule SLAM-associated protein (SAP) underlie the primary immunodeficiency disease X-linked lymphoproliferative syndrome...
  7. Latour S, Gish G, Helgason C, Humphries R, Pawson T, Veillette A. Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product. Nat Immunol. 2001;2:681-90 pubmed
    ..protein (SAP) is a short intracellular molecule that is mutated in humans with X-linked lymphoproliferative (XLP) disease...
  8. Li C, Schibli D, Li S. The XLP syndrome protein SAP interacts with SH3 proteins to regulate T cell signaling and proliferation. Cell Signal. 2009;21:111-9 pubmed publisher
    The gene sap/shd1a, which encodes a 128-residue SH2 domain protein, is frequently deleted or mutated in the X-linked lymphoproliferative syndrome (XLP)...
  9. Li C, Chung B, Tao J, Iosef C, Aoukaty A, Wang Y, et al. The X-linked lymphoproliferative syndrome gene product SAP regulates B cell function through the FcgammaRIIB receptor. Cell Signal. 2008;20:1960-7 pubmed publisher
    ..XLP) is an immunodeficiency condition caused by mutation or deletion of the gene encoding the adaptor protein SAP/SH2D1A. Besides defects in T cell and NK cell function and an absence of NKT cells, XLP can also manifest as lymphomas ..

More Information

Publications94

  1. Hwang P, Li C, Morra M, Lillywhite J, Muhandiram D, Gertler F, et al. A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J. 2002;21:314-23 pubmed
    The SH2 domain protein SAP/SH2D1A, encoded by the X-linked lymphoproliferative (XLP) syndrome gene, associates with the hematopoietic cell surface receptor SLAM in a phosphorylation-independent manner...
  2. Li C, Iosef C, Jia C, Han V, Li S. Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors. J Biol Chem. 2003;278:3852-9 pubmed
    The X-linked lymphoproliferative (XLP) syndrome gene encodes a protein named SAP or SH2D1A that is composed of a single Src homology 2 (SH2) domain. Two models have been proposed for its function in lymphocyte signaling...
  3. Eissmann P, Watzl C. Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells. J Immunol. 2006;177:3170-7 pubmed
    ..that NTB-A is tyrosine phosphorylated in unstimulated human NK cells and associates with SLAM-associated protein (SAP) and EAT-2...
  4. Nichols K, Hom J, Gong S, Ganguly A, Ma C, Cannons J, et al. Regulation of NKT cell development by SAP, the protein defective in XLP. Nat Med. 2005;11:340-5 pubmed
    ..Here, we show that SAP, encoded by the SH2D1A gene locus, also has a crucial role during the development of NKT cells, a lymphocyte subset with immunoregulatory ..
  5. Sayos J, Wu C, Morra M, Wang N, Zhang X, Allen D, et al. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature. 1998;395:462-9 pubmed
    ..gene encoding SAP maps to the same area of the X chromosome as the locus for X-linked lymphoproliferative disease (XLP) and we found mutations in the SAP gene in three XLP patients...
  6. Pasquier B, Yin L, Fondaneche M, Relouzat F, Bloch Queyrat C, Lambert N, et al. Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product. J Exp Med. 2005;201:695-701 pubmed
    b>SAP is an adaptor protein expressed in T cells and natural killer cells...
  7. Gu C, Tangye S, Sun X, Luo Y, Lin Z, Wu J. The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation. Proc Natl Acad Sci U S A. 2006;103:14447-52 pubmed
    ..by the recent finding that mutations in SAP result in a rare but fatal X-linked lymphoproliferative disease (XLP)...
  8. Veillette A, Dong Z, Latour S. Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes. Immunity. 2007;27:698-710 pubmed
    ..in immune cells, as a result of their exquisite ability to associate with members of the SLAM-associated protein (SAP) family of adaptors...
  9. Ostrakhovitch E, Wang Y, Li S. SAP binds to CD22 and regulates B cell inhibitory signaling and calcium flux. Cell Signal. 2009;21:540-50 pubmed publisher
    The signaling lymphocyte activation molecule (SLAM)-associated protein (SAP or SH2D1A) is an important regulator of immune function which, when mutated or deleted, causes the X-linked lymphoproliferative syndrome (XLP)...
  10. Nagy N, Matskova L, Kis L, Hellman U, Klein G, Klein E. The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative disease. Proc Natl Acad Sci U S A. 2009;106:11966-71 pubmed publisher
    Deletion or mutation of the SAP gene is associated with the X-linked lymphoproliferative disease (XLP) that is characterized by extreme sensitivity to Epstein-Barr virus (EBV)...
  11. Snow A, Marsh R, Krummey S, Roehrs P, Young L, Zhang K, et al. Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency. J Clin Invest. 2009;119:2976-89 pubmed publisher
    ..It is most commonly defined molecularly by loss of expression of SLAM-associated protein (SAP). Despite this, there is little understanding of how SAP deficiency causes lymphocytosis following EBV infection...
  12. Baldanzi G, Pighini A, Bettio V, Rainero E, Traini S, Chianale F, et al. SAP-mediated inhibition of diacylglycerol kinase ? regulates TCR-induced diacylglycerol signaling. J Immunol. 2011;187:5941-51 pubmed publisher
    ..Inhibition of DGK? is dependent on the expression of SAP, an adaptor protein mutated in X-linked lymphoproliferative disease, which is essential for SLAM-mediated signaling ..
  13. Chen R, Relouzat F, Roncagalli R, Aoukaty A, Tan R, Latour S, et al. Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors. Mol Cell Biol. 2004;24:5144-56 pubmed
    ..In addition, the 2B4-induced signal was absolutely dependent on coexpression of SAP, a Src homology 2 (SH2) domain-containing adaptor associating with SLAM-related receptors and mutated in X-linked ..
  14. Nichols K, Harkin D, Levitz S, Krainer M, Kolquist K, Genovese C, et al. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc Natl Acad Sci U S A. 1998;95:13765-70 pubmed
    ..We describe here the presence of small deletions and intragenic mutations that specifically disrupt a gene named DSHP in 6 of 10 unrelated patients with XLP...
  15. Coffey A, Brooksbank R, Brandau O, Oohashi T, Howell G, Bye J, et al. Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene. Nat Genet. 1998;20:129-35 pubmed
    ..We have identified a gene, SH2D1A, that is mutated in XLP patients and encodes a novel protein composed of a single SH2 domain...
  16. Li S, Gish G, Yang D, Coffey A, Forman Kay J, Ernberg I, et al. Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A. Curr Biol. 1999;9:1355-62 pubmed
    ..SAP (also known as SH2D1A or DSHP), the product of the gene that is mutated in human X-linked lymphoproliferative (XLP) disease, comprises ..
  17. Sayos J, Martin M, Chen A, Simarro M, Howie D, Morra M, et al. Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP. Blood. 2001;97:3867-74 pubmed
    ..SAP/SH2D1A, the product of the gene mutated in XLP, is a small protein that comprises a single SH2 domain and a short tail of ..
  18. Bottino C, Falco M, Parolini S, Marcenaro E, Augugliaro R, Sivori S, et al. NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease. J Exp Med. 2001;194:235-46 pubmed
    ..NTB-A undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs)...
  19. Chan B, Lanyi A, Song H, Griesbach J, Simarro Grande M, Poy F, et al. SAP couples Fyn to SLAM immune receptors. Nat Cell Biol. 2003;5:155-60 pubmed
    b>SAP (SLAM-associated protein) is a small lymphocyte-specific signalling molecule that is defective or absent in patients with X-linked lymphoproliferative syndrome (XLP)...
  20. Sanzone S, Zeyda M, Saemann M, Soncini M, Holter W, Fritsch G, et al. SLAM-associated protein deficiency causes imbalanced early signal transduction and blocks downstream activation in T cells from X-linked lymphoproliferative disease patients. J Biol Chem. 2003;278:29593-9 pubmed
    ..protein) protein is associated with a severe immunodeficiency, the X-linked lymphoproliferative disease (XLP) characterized by an inappropriate immune reaction against Epstein-Barr virus infection often resulting in a fatal ..
  21. Engel P, Eck M, Terhorst C. The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease. Nat Rev Immunol. 2003;3:813-21 pubmed
    b>SAP (signalling lymphocytic activation molecule (SLAM)-associated protein) is a T- and natural killer (NK)-cell-specific protein containing a single SH2 domain encoded by a gene that is defective or absent in patients with X-linked ..
  22. Dupré L, Andolfi G, Tangye S, Clementi R, Locatelli F, Arico M, et al. SAP controls the cytolytic activity of CD8+ T cells against EBV-infected cells. Blood. 2005;105:4383-9 pubmed
    ..In patients affected by X-linked lymphoproliferative (XLP) disease, mutations in the SH2D1A gene result in defective lytic activity...
  23. Mazzio E, Lewis C, Soliman K. Transcriptomic Profiling of MDA-MB-231 Cells Exposed to Boswellia Serrata and 3-O-Acetyl-B-Boswellic Acid; ER/UPR Mediated Programmed Cell Death. Cancer Genomics Proteomics. 2017;14:409-425 pubmed
    ..01]; and cystathionine gamma-lyase (CTH) [+11.12]. The anti-cancer effects of the historically used frankincense sap (BSE) appear to involve major impact on the ER/UPR response, concomitant to effecting multiple targets counter to ..
  24. Acera A, Manresa J, Rodriguez D, Rodriguez A, Bonet J, Trapero Bertran M, et al. Increasing Cervical Cancer Screening Coverage: A Randomised, Community-Based Clinical Trial. PLoS ONE. 2017;12:e0170371 pubmed publisher
    ..study is a community-based clinical trial to improve coverage of population-based screening in the Cerdanyola SAP area in Barcelona.A total of 32,858 women residing in the study area, aged 30 to 70 years were evaluated...
  25. Sugiyama T, Kimura S, Ohtani H, Hishikari K, Kojima K, Sagawa Y, et al. Relationship between quantities of tissue prolapse after percutaneous coronary intervention and neointimal hyperplasia at follow-up on serial optical coherence tomography examination. Int J Cardiol. 2017;241:470-477 pubmed publisher
    ..We evaluated 145 native coronary lesions (89 lesions with stable angina pectoris [SAP] and 56 with acute coronary syndrome [ACS])...
  26. Hiery E, Poetsch A, Moosbauer T, Amin B, Hofmann J, Burkovski A. A Proteomic Study of Clavibacter Michiganensis Subsp. Michiganensis Culture Supernatants. Proteomes. 2015;3:411-423 pubmed publisher
    ..i>michiganensis reacts to a sucrose- and glucose-depleted medium similar to the xylem sap by utilizing amino acids and host cell polymers as well as their degradation products, mainly peptides, amino acids ..
  27. Xia G, Wang Y, Huang Z. The Correlation of Serum Myeloid-Related Protein-8/14 and Eosinophil Cationic Protein in Patients with Coronary Artery Disease. Biomed Res Int. 2016;2016:4980251 pubmed publisher
    ..CAD group including unstable angina pectoris (UAP), acute myocardial infarction (AMI), and stable angina pectoris (SAP). Thirty-six individuals with normal coronary artery served as the control group...
  28. Bowd C, Zangwill L, Weinreb R, Medeiros F, Belghith A. Estimating Optical Coherence Tomography Structural Measurement Floors to Improve Detection of Progression in Advanced Glaucoma. Am J Ophthalmol. 2017;175:37-44 pubmed publisher
    ..of interest that did not reach the measurement floor at baseline were calculated in 87 eyes with advanced glaucoma (SAP MD ≤-12 dB). Global change over time in longitudinal eyes was -1.51 μm/year for MRW, -0...
  29. Kueakhai P, Changklungmoa N, Waseewiwat P, Thanasinpaiboon T, Cheukamud W, Chaichanasak P, et al. Characterization and vaccine potential of Fasciola gigantica saposin-like protein 1 (SAP-1). Vet Parasitol. 2017;233:115-122 pubmed publisher
    ..These indicated that rFgSAP-1 has strong potential as a vaccine candidate against F. gigantica, whose efficacy will be studied further in large economic animals including cattle, sheep, and goat. ..
  30. Vera Estrella R, Gómez Méndez M, Amezcua Romero J, Barkla B, Rosas Santiago P, Pantoja O. Cadmium and zinc activate adaptive mechanisms in Nicotiana tabacum similar to those observed in metal tolerant plants. Planta. 2017;246:433-451 pubmed publisher
    ..of heavy metals did not affect the chlorophyll and carotenoid levels, while variable effects were observed in cell sap osmolarity...
  31. Van Camp J, Hubeau M, Van den Bulcke J, VAN Acker J, Steppe K. Cambial pinning relates wood anatomy to ecophysiology in the African tropical tree Maesopsis eminii. Tree Physiol. 2017;:1-11 pubmed publisher
    ..cambial wounding) to timestamp anatomical X-ray computed microtomography images with continuous measurements of sap flow and stem diameter variations...
  32. Naidoo N, Ghai M, Moodley K, Mkize L, Martin L, McFarlane S, et al. Modified RS-LAMP assay and use of lateral flow devices for rapid detection of Leifsonia xyli subsp. xyli. Lett Appl Microbiol. 2017;65:496-503 pubmed publisher
    ..from leaf sheath discs as an alternate template for the LAMP assay was found to be less sensitive than xylem sap. The preprepared master mix could be stored for up to 4 months at -20°C without any reduction in performance...
  33. Ritchie L, Tate R, Chamberlain L, Robertson G, Zagnoni M, Sposito T, et al. Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons. Neuropharmacology. 2018;135:1-10 pubmed publisher
    ..function was reproduced in iPSC-derived cortical neurons, with poly I:C (25 μg/ml, 1h) significantly inhibiting sAP firing...
  34. Strickland M, Ehrlich L, Watanabe S, Khan M, Strub M, Luan C, et al. Tsg101 chaperone function revealed by HIV-1 assembly inhibitors. Nat Commun. 2017;8:1391 pubmed publisher
    ..Tsg101 possesses an ubiquitin (Ub) E2 variant (UEV) domain with a pocket that can bind PT/SAP motifs and another pocket that can bind Ub...
  35. Karuppanapandian T, Geilfus C, Mühling K, Novak O, Gloser V. Early changes of the pH of the apoplast are different in leaves, stem and roots of Vicia faba L. under declining water availability. Plant Sci. 2017;255:51-58 pubmed publisher
    ..increase in pH of xylem or leaf apoplast was not the remote effect of an acropetal transport of alkaline sap from root, because root xylem acidified during progressive soil drying, whereas the shoot apoplast alkalized...
  36. Nagatoshi A, Ueda M, Ueda A, Tasaki M, Inoue Y, Ma Y, et al. Serum amyloid P component: A novel potential player in vessel degeneration in CADASIL. J Neurol Sci. 2017;379:69-76 pubmed publisher
    ..The analyses detected serum amyloid P component (SAP), annexin A2, and periostin as the proteins with the largest increase in the samples, which also demonstrated ..
  37. Yang D, Pan S, Ding Y, Tyree M. Experimental evidence for negative turgor pressure in small leaf cells of Robinia pseudoacacia L versus large cells of Metasequoia glyptostroboides Hu et W.C.Cheng. 1. Evidence from pressure-volume curve analysis of dead tissue. Plant Cell Environ. 2017;40:351-363 pubmed publisher
    ..i) Tissues killed by heating to 60 or 80?°C or by freezing in liquid nitrogen all became equally leaky to cell sap solutes and all seemed to pass freely through the cell walls...
  38. Puri S, Friedman J, Saraswat D, Kumar R, Li R, Ruszaj D, et al. Candida albicans Shed Msb2 and Host Mucins Affect the Candidacidal Activity of Salivary Hst 5. Pathogens. 2015;4:752-63 pubmed publisher
    ..most likely a result of proteolytic degradation of Hst 5 since this effect is abrogated with heat inactivated Sap 6. We further show that just like C...
  39. Sandlund J, Shurtleff S, Onciu M, Horwitz E, Leung W, Howard V, et al. Frequent mutations in SH2D1A (XLP) in males presenting with high-grade mature B-cell neoplasms. Pediatr Blood Cancer. 2013;60:E85-7 pubmed publisher
    X-linked lymphoproliferative syndrome (XLP) is caused by mutations in SH2D1A, and is associated with overwhelming infectious mononucleosis, aplastic anemia, hypogammaglobulinemia, and B-cell lymphomas...
  40. Meira Freitas D, Tatham A, Lisboa R, Kuang T, Zangwill L, Weinreb R, et al. Predicting progression of glaucoma from rates of frequency doubling technology perimetry change. Ophthalmology. 2014;121:498-507 pubmed publisher
    ..technology (FDT) to predict the development of glaucomatous visual field loss on standard automated perimetry (SAP) in glaucoma suspects. Prospective, observational cohort study...
  41. Zhang Z, Chao M, Wang S, Bu J, Tang J, Li F, et al. Proteome quantification of cotton xylem sap suggests the mechanisms of potassium-deficiency-induced changes in plant resistance to environmental stresses. Sci Rep. 2016;6:21060 pubmed publisher
    ..Low K (LK) treatment significantly decreased the K and protein contents of xylem sap. Totally, 258 peptides were qualitatively identified in the xylem sap of cotton seedlings, of which, 90...
  42. Helland R, Berglund G, Otlewski J, Apostoluk W, Andersen O, Willassen N, et al. High-resolution structures of three new trypsin-squash-inhibitor complexes: a detailed comparison with other trypsins and their complexes. Acta Crystallogr D Biol Crystallogr. 1999;55:139-48 pubmed
  43. Papavasileiou V, Milionis H, Smith C, Makaritsis K, Bray B, Michel P, et al. External Validation of the Prestroke Independence, Sex, Age, National Institutes of Health Stroke Scale (ISAN) Score for Predicting Stroke-Associated Pneumonia in the Athens Stroke Registry. J Stroke Cerebrovasc Dis. 2015;24:2619-24 pubmed publisher
    ..Institutes of Health Stroke Scale (ISAN) score was developed recently for predicting stroke-associated pneumonia (SAP), one of the most common complications after stroke...
  44. Laitaoja M, Tossavainen H, Pihlajamaa T, Valjakka J, Viiri K, Lohi O, et al. Redox-dependent disulfide bond formation in SAP30L corepressor protein: Implications for structure and function. Protein Sci. 2016;25:572-86 pubmed publisher
    ..SAP30L, together with a highly homologous SAP30 as well as other SAP proteins (i.e...
  45. Saiki S, Ishida A, Yoshimura K, Yazaki K. Physiological mechanisms of drought-induced tree die-off in relation to carbon, hydraulic and respiratory stress in a drought-tolerant woody plant. Sci Rep. 2017;7:2995 pubmed publisher
    ..The ratio of the total leaf area to the twig sap area was used as a health indicator after drought damage...
  46. Muller A, Leroy J, Hénon T, Patry I, Samain E, Chirouze C, et al. Surgical antibiotic prophylaxis compliance in a university hospital. Anaesth Crit Care Pain Med. 2015;34:289-94 pubmed publisher
    To assess surgical antibiotic prophylaxis (SAP) practices in a university hospital in order to identify risk factors associated with non-compliance. Retrospective monocentric study conducted over a 4-month period...
  47. Takei M, Kitamura N, Shiraiwa H, Inomata H, Nozaki T, Kuwana Y, et al. [The possible curative therapy for rheumatoid arthritis--EBV infection control gene SAP and its application]. Nihon Rinsho Meneki Gakkai Kaishi. 2008;31:141-51 pubmed
    ..The key points of this new therapy are SAP (signaling lymphocytic-activation molecule associated protein) or SH2D1A (Src homology 2 domain-containing protein)...
  48. Wu C, Zou L, Shi S, Tong Z, Shen X, Yang D, et al. The role of hypertriglyceridemia for acute kidney injury in the course of acute pancreatitis and an animal model. Pancreatology. 2017;17:561-566 pubmed publisher
    ..Severe acute pancreatitis (SAP) model was established by retrograde injection of 0.5% sodium taurocholate (0...
  49. Lin Z, Qi J. Hydro-dam - A nature-based solution or an ecological problem: The fate of the Tonlé Sap Lake. Environ Res. 2017;158:24-32 pubmed publisher
    ..In this study, as the first step to answer this question and using the Tonlé Sap Lake as an example, we quantified one of the impacts of hydro-dams on lake ecosystem's phenology in terms of open ..
  50. Mitchell P, McAdam S, Pinkard E, Brodribb T. Significant contribution from foliage-derived ABA in regulating gas exchange in Pinus radiata. Tree Physiol. 2017;37:236-245 pubmed publisher
    ..foliar water potential, causing a dramatic increase in ABA level in leaves and concentrations in the xylem sap of shoots (4032 ng ml-1), while root xylem sap concentrations remained low (43 ng ml-1)...
  51. Liu J, Zhou M, Delhaize E, Ryan P. Altered Expression of a Malate-Permeable Anion Channel, OsALMT4, Disrupts Mineral Nutrition. Plant Physiol. 2017;175:1745-1759 pubmed publisher
    ..released malate from the roots constitutively and had 2-fold higher malate concentrations in the xylem sap than nulls, indicating greater concentrations of malate in the apoplast...
  52. Killiny N. Metabolomic comparative analysis of the phloem sap of curry leaf tree (Bergera koenegii), orange jasmine (Murraya paniculata), and Valencia sweet orange (Citrus sinensis) supports their differential responses to Huanglongbing. Plant Signal Behav. 2016;11:e1249080 pubmed
    ..D. citri feeds on the phloem sap where CLas grows. It has been shown that orange jasmine was a better host than curry leaf tree to D. citri...
  53. Li N, Wang B, Cai S, Liu P. The Role of Serum High Mobility Group Box 1 and Interleukin-6 Levels in Acute Pancreatitis: A Meta-Analysis. J Cell Biochem. 2018;119:616-624 pubmed publisher
    ..meta-analysis, comprising of 896 cases of mild acute pancreatitis (MAP), 700 cases of severe acute pancreatitis (SAP) as well as 312 healthy controls...
  54. Bari V, Ranucci M, De Maria B, Cairo B, Pistuddi V, Porta A. Model-based directional analysis of cardiovascular variability identifies patients developing atrial fibrillation after coronary artery bypass grafting. Int J Cardiol. 2018;258:97-102 pubmed publisher
    ..model-based analysis of the spontaneous fluctuations of heart period (HP) and systolic arterial pressure (SAP) can identify subjects at risk to develop AF after coronary artery bypass graft (CABG) surgery...
  55. Debeljak M, Podkrajsek K, Aplenc R, Jazbec J. X-linked lymphoproliferative disease with a novel SH2D1A gene mutation. Pediatr Blood Cancer. 2008;50:187 pubmed
  56. Sawada S, Takei M, Inomata H, Nozaki T, Shiraiwa H. What is after cytokine-blocking therapy, a novel therapeutic target--synovial Epstein-Barr virus for rheumatoid arthritis. Autoimmun Rev. 2007;6:126-30 pubmed
    ..Here, we provide an overview of the implications for novel approaches to therapy for RA patients, based on the most recent available evidences of anti-viral agents. ..
  57. Le L, Umar A, Iburaim A, Moore N. Constituents and Antioxidant Activity of Bleeding Sap from Various Xinjiang Grapes. Pharmacogn Mag. 2017;13:S726-S730 pubmed publisher
    Wine grape sap or bleeding sap of grapes (GBS) is commonly used in Xinjiang (China) for therapeutic aims. Do variations in composition related to region and variety affect its properties?
  58. Li J, Meng L, Zhang H, Wang X. Efficacy and drug resistance of antibacterials in patients' with acute pancreatitis and stress ulcer bleeding. Pak J Pharm Sci. 2017;30:1905-1909 pubmed
    ..the same time, we treated patients with antimicrobial agents based on the epidemiology of sever acute pancreatitis (SAP) infection...
  59. Han C, Zeng J, Lin R, Liu J, Qian W, Ding Z, et al. The utility of neutrophil to lymphocyte ratio and fluid sequestration as an early predictor of severe acute pancreatitis. Sci Rep. 2017;7:10704 pubmed publisher
    It is important to identify the patients with high-risk progression to develop severe acute pancreatitis (SAP)...
  60. Liu D, Hu X, Jiang X, Gao B, Wan C, Chen C. Characterization of a novel splicing mutation in UNC13D gene through amplicon sequencing: a case report on HLH. BMC Med Genet. 2017;18:135 pubmed publisher
    ..Six genes including SH2D1A, PRF1, UNC13D, STX11, STXBP2 and XIAP were reported as causative genes in most cases...
  61. Sumazaki R, Kanegane H, Osaki M, Fukushima T, Tsuchida M, Matsukura H, et al. SH2D1A mutations in Japanese males with severe Epstein-Barr virus--associated illnesses. Blood. 2001;98:1268-70 pubmed
    ..characterized by immunodeficiency to Epstein-Barr virus (EBV) infection, has been linked to mutations in the SH2D1A gene...
  62. Gotsch S, Dawson T, Draguljić D. Variation in the resilience of cloud forest vascular epiphytes to severe drought. New Phytol. 2017;: pubmed publisher
    ..Epiphytes were instrumented with sap flow probes in each site...
  63. Long Z, Gao L, Li Y, Kang B, Lee J, Ge J, et al. Micro Galvanic Cell To Generate PtO and Extend the Triple-Phase Boundary during Self-Assembly of Pt/C and Nafion for Catalyst Layers of PEMFC. ACS Appl Mater Interfaces. 2017;9:38165-38169 pubmed publisher
    The self-assembly powder (SAP) with varying Nafion content was synthesized and characterized by XRD, XPS, HRTEM, and mapping...
  64. Pita P, Rodríguez Calcerrada J, Medel D, Gil L. Further insights into the components of resistance to Ophiostoma novo-ulmi in Ulmus minor: hydraulic conductance, stomatal sensitivity and bark dehydration. Tree Physiol. 2018;38:252-262 pubmed publisher
    ..Higher hydraulic constraints to sap flow in resistant clones may determine higher stomatal sensitivity to VPD and so contribute to DED resistance by ..
  65. López Bernal Á, García Tejera O, Testi L, Orgaz F, Villalobos F. Stomatal oscillations in olive trees: analysis and methodological implications. Tree Physiol. 2018;38:531-542 pubmed publisher
    ..Three experiments with young potted olives and one with large field-grown trees were performed. Sap flow measurements were always used to monitor the occurrence of oscillations, with additional determinations of ..
  66. Gobelius L, Lewis J, Ahrens L. Plant Uptake of Per- and Polyfluoroalkyl Substances at a Contaminated Fire Training Facility to Evaluate the Phytoremediation Potential of Various Plant Species. Environ Sci Technol. 2017;51:12602-12610 pubmed publisher
    ..system with mixed stands of silver birch and spruce in combination with regular harvest of leaves and birch sap and an understory of ground elder, it is potentially feasible to remove 1...
  67. Kasal Slavik T, Eschweiler J, Kleist E, Mumm R, Goldbach H, Schouten A, et al. Early biotic stress detection in tomato (Solanum lycopersicum) by BVOC emissions. Phytochemistry. 2017;144:180-188 pubmed publisher
    ..Tomato plants were exposed to two common fungal pathogens, Botrytis cinerea and Oidium neolycopesici and the sap-sucking aphid Myzus persicae...
  68. Matsumoto Y, Nagoshi H, Yoshida M, Kato S, Kuroda J, Shimura K, et al. Expression of Master Regulators of T-cell, Helper T-cell and Follicular Helper T-cell Differentiation in Angioimmunoblastic T-cell Lymphoma. Intern Med. 2017;56:2851-2856 pubmed publisher
    ..In addition, BCL6 and the surface markers of TFH (CXCL13, PD-1, and SAP) were detected in 11 (73%), 8 (53%), 14 (93%), and all patients, respectively...
  69. Camp A, Weinreb R. Will Perimetry Be Performed to Monitor Glaucoma in 2025?. Ophthalmology. 2017;124:S71-S75 pubmed publisher
    ..to examine the visual field have been refined from early kinetic perimetry to current standard automated perimetry (SAP). Clinicians now use SAP for the diagnosis and management of glaucoma throughout the world...
  70. Nichols N, Craig T, Tanner M. Phrenic long-term facilitation following intrapleural CTB-SAP-induced respiratory motor neuron death. Respir Physiol Neurobiol. 2018;256:43-49 pubmed publisher
    ..Intrapleural injections of cholera toxin B fragment conjugated to saporin (CTB-SAP) selectively kill respiratory motor neurons and mimic motor neuron death observed in SOD1G93A rats...
  71. Sorkheh K, Dehkordi M, Ercisli S, Hegedus A, Halász J. Comparison of traditional and new generation DNA markers declares high genetic diversity and differentiated population structure of wild almond species. Sci Rep. 2017;7:5966 pubmed publisher
    ..retrotransposon-microsatellite amplified polymorphism (REMAP), sequence-specific amplification polymorphism (S-SAP), amplified fragment length polymorphism (AFLP), inter simple sequence repeat (ISSR) and simple sequence repeats (..
  72. Pant S, Schenkel F, Leyva Baca I, Sharma B, Karrow N. Identification of polymorphisms in bovine TLR2 and CARD15,associations between CARD15 polymorphisms and milk somatic cell score in Canadian Holsteins, and functional relevance of SNP c.3020A>T. Dev Biol (Basel). 2008;132:247-53 pubmed
    ..A selective DNA pool was constructed based on the estimated breeding values (EBVs) for somatic cell score (SCS)...
  73. Mejstrikova E, Janda A, Hrusak O, Bucková H, Vlckova M, Hancarova M, et al. Skin lesions in a boy with X-linked lymphoproliferative disorder: comparison of 5 SH2D1A deletion cases. Pediatrics. 2012;129:e523-8 pubmed publisher
    b>SH2D1A gene defects are the cause of X-linked lymphoproliferative disorder (XLP-1), a rare condition characterized by severe immune dysregulation...
  74. Sandra N, Jailani A, Jain R, Mandal B. Genome characterization, infectivity assays of in vitro and in vivo infectious transcripts of soybean yellow mottle mosaic virus from India reveals a novel short mild genotype. Virus Res. 2017;232:96-105 pubmed publisher
    ..plant species with agroinoculation of p35SSYMMV-O4 showed delay in symptoms but indistinguishable from mechanical sap inoculation and the infection was confirmed by DAC-ELISA, RT-PCR and mechanical transmission to new plants...
  75. Timur S, Bhattarai P, Gursoy R, Vural I, Khaw B. Design and In Vitro Evaluation of Bispecific Complexes and Drug Conjugates of Anticancer Peptide, LyP-1 in Human Breast Cancer. Pharm Res. 2017;34:352-364 pubmed publisher
    b>LyP-1, a nine-amino-acid tumor homing peptide, selectively binds to its cognate receptor, p32. Overexpression of p32 in certain tumors should allow use of LyP-1 as a targeting agent for the delivery of therapeutic or diagnostic agents...
  76. Koochakzadeh L, Hosseinverdi S, Hedayat M, Farahani F, Tofighi A, Eghbali M, et al. Study of SH2D1A gene mutation in paediatric patients with B-cell lymphoma. Allergol Immunopathol (Madr). 2015;43:568-70 pubmed publisher
    ..Eleven patients had laboratory evidence of EBV infection by serology and quantitative PCR. The SH2D1A gene analysis was negative in all patients...
  77. Tahir M, Bajwa S, Mansoor S, Briddon R, Khan W, Scheffler B, et al. Evaluation of carbon nanotube based copper nanoparticle composite for the efficient detection of agroviruses. J Hazard Mater. 2018;346:27-35 pubmed publisher
    ..3% of the initial signal value. This sensor was able to detect the presence of viruses in sap extracted from cotton leaves, thus providing a promising platform to detect a range of other crops-infecting ..
  78. Norgrove L. Neither dark nor light but shades in-between: cocoa merits a finer sampling. Glob Chang Biol. 2017;: pubmed publisher
    ..During the extremely dry period, the cocoa in agroforestry systems had massive stress, reduced sap flux and high mortality. This article is protected by copyright. All rights reserved.
  79. Wiedemann A, Marañón Jiménez S, Rebmann C, Herbst M, Cuntz M. An empirical study of the wound effect on sap flux density measured with thermal dissipation probes. Tree Physiol. 2016;36:1471-1484 pubmed
    The insertion of thermal dissipation (TD) sensors on tree stems for sap flux density (SFD) measurements can lead to SFD underestimations due to a wound formation close to the drill hole...
  80. Zhao X, Zhao P, Zhang Z, Zhu L, Hu Y, Ouyang L, et al. Culm Age and Rhizome Affects Night-Time Water Recharge in the Bamboo Phyllostachys pubescens. Front Plant Sci. 2017;8:1928 pubmed publisher
    ..We studied the day- and night-time sap flow response to culm age and rhizome structure in three age levels (juvenile, mature, and senescent) of ..
  81. Aldhamen Y, Rastall D, Chen W, Seregin S, Pereira Hicks C, Godbehere S, et al. CRACC-targeting Fc-fusion protein induces activation of NK cells and DCs and improves T cell immune responses to antigenic targets. Vaccine. 2016;34:3109-3118 pubmed publisher
    ..As EAT-2 is the only SAP adaptor that interacts with the CRACC receptor, we hypothesized that technologies that specifically modulate CRACC ..
  82. Kunasundari B, Arai T, Sudesh K, Hashim R, Sulaiman O, Stalin N, et al. Detoxification of Sap from Felled Oil Palm Trunks for the Efficient Production of Lactic Acid. Appl Biochem Biotechnol. 2017;183:412-425 pubmed publisher
    The availability of fermentable sugars in high concentrations in the sap of felled oil palm trunks and the thermophilic nature of the recently isolated Bacillus coagulans strain 191 were exploited for lactic acid production under non-..
  83. Saborit Villarroya I, Martinez Barriocanal A, Oliver Vila I, Engel P, Sayos J, Martin M. The adaptor 3BP2 activates CD244-mediated cytotoxicity in PKC- and SAP-dependent mechanisms. Mol Immunol. 2008;45:3446-53 pubmed publisher
    ..intracellular multiproteic signaling network that involves the adaptors X-linked lymphoproliferative gene product SAP and 3BP2...
  84. He J, Mao E, Jing F, Jiang H, Xu W, Yang W, et al. [PK/PD of vancomycin in patients with severe acute pancreatitis combined with augmented renal clearance]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:810-814 pubmed publisher
    ..and the pharmacokinetics/pharmacodynamics (PK/PD) of vancomycin in patients with severe acute pancreatitis (SAP), and analyze the effect of vancomycin continuous infusion for optimizing the characteristics of its PK/PD...