Genomes and Genes
Gene Symbol: SH2B2
Description: SH2B adaptor protein 2
Alias: APS, SH2 and PH domain-containing adapter protein APS, SH2B adapter protein 2, adapter protein with pleckstrin homology and Src homology 2 domains, adaptor protein with pleckstrin homology and src homology 2 domains
Publications143 found, 100 shown here
- Adenosine-5'-phosphosulfate kinase from Penicillium chrysogenum: ligand binding properties and the mechanism of substrate inhibitionF Renosto
Department of Biochemistry and Biophysics, University of California, Davis 95616
Arch Biochem Biophys 284:30-4. 199135S]Adenosine-5'-phosphosulfate (APS) binding to Penicillium chrysogenum APS kinase was measured by centrifugal ultrafiltration...
- [Comparison of the characteristics of methacholine and of propranolol in the assessment of aspecific hyperreactivity of the airways]G Schultze-Werninghaus
, Abt. f. Pneumologie, Frankfurt/Main
Pneumologie 45:729-33. 1991..The aerosol was administered by a dosimeter (APS, Jaeger), using doubling concentrations, with a maximum of 25 mg/ml (2.5%), the lowest concentrations being 0...
- ATP sulfurylase from higher plants: kinetic and structural characterization of the chloroplast and cytosol enzymes from spinach leafF Renosto
Department of Biochemistry and Biophysics, University of California, Davis 95616
Arch Biochem Biophys 307:272-85. 1993..03 +/- 0.01 adenosine-5'-phosphosulfate (APS) synthesis units x gram fresh weight-1)...
- Effect of valsartan on angiotensin II- and vasopressin-degrading activities in the kidney of normotensive and hypertensive ratsI Prieto
Unit of Physiology, , Bldg. B3, 23071, , Spain
Horm Metab Res 33:559-63. 2001..Given that aminopeptidases (APs) play a major role in the metabolism of local peptides involved in blood pressure control, studying them helped us ..
- Artificial pulmonary surfactant as a carrier for intratracheally instilled insulinYing Ji
Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, China
Acta Pharmacol Sin 28:744-50. 2007..bioavailabilities and effects on lung injury alleviation of 4 insulin- artificial pulmonary surfactant (INS-APS) preparations were studied in normal rats...
- Tachykinin NK1 but not NK2 receptors mediate non-cholinergic excitatory junction potentials in the circular muscle of guinea-pig colonV Zagorodnyuk
Department Neuro muscular Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
Br J Pharmacol 110:795-803. 1993..j.p.) followed by e.j.p. with superimposed action potentials (APs) and contraction. Addition of either NG-nitro-L-arginine (L-NOARG, 0.1 mM) or apamin (0...
- In-hospital complications among survivors of admission for congestive heart failure, chronic obstructive pulmonary disease, or diabetes mellitusJ M Geraci
Houston Center for Quality of Care and Utilization Studies, Houston Veterans Affairs Medical Center, Baylor College of Medicine 77030, USA
J Gen Intern Med 10:307-14. 1995..9%). Patient age, the presence of comorbid diseases, and the Acute Physiology Score (APS) of APACHE II were associated with complication occurrence...
- Obesity and related metabolic abnormalities during antipsychotic drug administration: mechanisms, management and research perspectivesT Baptista
Los Andes University School of Medicine, Department of Physiology, Merida, Venezuela
Pharmacopsychiatry 35:205-19. 2002Excessive body weight gain (BWG) is a common side effect of some typical and atypical antipsychotic drugs (APs)...
- Probing antiphospholipid-mediated thrombosis: the interplay between anticardiolipin antibodies and endothelial cellsS S Pierangeli
Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia, USA
Lupus 12:539-45. 2003The association of antiphospholipid (aPL) antibodies with thrombosis in patients with antiphospholipid syndrome (APS) is well documented in humans and in animal studies...
- Determinants of risk for venous and arterial thrombosis in primary antiphospholipid syndrome and in antiphospholipid syndrome with systemic lupus erythematosusAdriana Danowski
Rheumatology Department, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 7500, Baltimore MD 21205, USA
J Rheumatol 36:1195-9. 2009Antiphospholipid syndrome (APS) is characterized by thrombosis (venous and arterial) and pregnancy loss in conjunction with the lupus anticoagulant, IgG or IgM anticardiolipin, or IgG or IgM anti-beta2-glycoprotein I...
- Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49C Thollon
Division Pathologies Cardiaques et Vasculaires, Institut de Recherches Servier, Suresnes, France
Br J Pharmacol 112:37-42. 1994..Intracellular recordings of action potentials (APs) were performed with conventional glass microelectrodes. 2...
- Nerve growth factor, sphingomyelins, and sensitization in sensory neuronsGrant D Nicol
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Sheng Li Xue Bao 60:603-4. 2008..NGF or 1 mmol/L N-acetyl sphingosine (C2-ceramide) produced a 3-4 fold increase in the number of action potentials (APs) evoked by a ramp of depolarizing current in a time-dependent manner...
- Crystal structure of ATP sulfurylase from Penicillium chrysogenum: insights into the allosteric regulation of sulfate assimilationI J MacRae
Section of Molecular and Cellular Biology and Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA
Biochemistry 40:6795-804. 2001..7 kDa subunits (573 residues). The C-terminal allosteric domain of each subunit is homologous to APS kinase...
- Human 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase: biochemistry, molecular biology and genetic deficiencyK V Venkatachalam
Department of Biochemistry, College of Medical Sciences, Health Professions Division, Nova Southeastern University, 3200 South University Dr, Ft Lauderdale, FL 33328 2018, USA
IUBMB Life 55:1-11. 2003..First inorganic sulfate combines with ATP to form adenosine 5'-phosphosulfate (APS) and pyrophosphate catalyzed by ATP sulfurylase domain and in the second step, APS combines with another molecule ..
- Complement activation in patients with primary antiphospholipid syndromeK Oku
Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Ann Rheum Dis 68:1030-5. 2009To investigate the significance of complement activation in patients with primary antiphospholipid syndrome (APS).
- Indoor air pollution by alkylphenols in TokyoI Saito
Department of Environmental Health and Toxicology, Division of Environment Health, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan
Indoor Air 14:325-32. 2004The purposes of this study were to develop an analytical method for airborne alkylphenols (APs) using the gas chromatography/mass spectrometry (GC/MS)-SIM method and to investigate airborne C4-C9 APs pollution in houses, offices, and ..
- Cross-reactivity between anti-cardiolipin, anti-high-density lipoprotein and anti-apolipoprotein A-I IgG antibodies in patients with systemic lupus erythematosus and primary antiphospholipid syndromeJ Delgado Alves
Centre for Rheumatology, Department of Medicine, University College London, London, UK
Rheumatology (Oxford) 42:893-9. 2003..important complication of patients with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). One suggested mechanism may be the action of autoantibodies directed against plasma lipoproteins...
- Double heterozygosity polymorphisms for platelet glycoproteins Ia/IIa and IIb/IIIa increases arterial thrombosis and arteriosclerosis in patients with the antiphospholipid syndrome or with systemic lupus erythematosusS Jimenez
Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Barcelona, Catalonia, Spain
Ann Rheum Dis 67:835-40. 2008..GP) Ib-alpha, Ia/IIa and IIb/IIIa and their correlation with the development of arterial thrombosis and preclinical arteriosclerosis in patients with antiphospholipid syndrome (APS) or with systemic lupus erythematosus (SLE).
- Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease predictionCorrado Betterle
Chair of Clinical Immunology and Allergy, Department of Medical and Surgical Sciences, University of Padova, I 35128, Padova, Italy
Endocr Rev 23:327-64. 2002..Furthermore, the autoimmune polyglandular syndromes (APS) associated with AD (revised classification, animal models, genetics, natural history) have been discussed...
- Manipulation of thiol contents in plantsR Höfgen
Max Planck Institut fur Molekulare Pflanzenphysiologie, Golm, Federal Republic of Germany
Amino Acids 20:291-9. 2001..relatively inert sulfate molecule is activated through binding to ATP forming adenosine-5'-phosphosulfate (APS). This enzymatic step is controlled through the enzyme ATP-sulfurylase (ATP-S)...
- Susceptibility alleles and haplotypes of human leukocyte antigen DRB1, DQA1, and DQB1 in autoimmune polyglandular syndrome type III in Japanese populationKozo Hashimoto
Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Nankoku, Japan
Horm Res 64:253-60. 2005..However, little has been reported on the susceptibility HLA class II haplotypes in Japanese patients with autoimmune polyglandular syndrome type II and type III (APS III).
- Autoantibodies against type I interferons as an additional diagnostic criterion for autoimmune polyendocrine syndrome type IAntonella Meloni
Pediatric Clinic II, Ospedale Microcitemico and Dipartimento di Sciencze Biomediche e Biotechno logiche, University of Cagliari, Cagliari, Sardinia, Italy
J Clin Endocrinol Metab 93:4389-97. 2008In autoimmune polyendocrinopathy syndrome type I (APS-I), mutations in the autoimmune regulator gene (AIRE) impair thymic self-tolerance induction in developing T cells...
- Non-radioactive adenosine 5'-phosphosulfate sulfotransferase assay by coupling with sulfite reductase and O-acetylserine(thiol)lyaseT Ara
Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University, Japan
Biosci Biotechnol Biochem 61:621-4. 1997Adenosine 5'-phosphosulfate (APS) sulfotransferase is thought to be an enzyme that transfers the sulfo-group of APS to a carrier compound with a thiol group in the assimilatory sulfate reduction pathway of higher plants...
- Photo degradation of methyl orange an azo dye by advanced Fenton process using zero valent metallic iron: influence of various reaction parameters and its degradation mechanismL Gomathi Devi
Department of Post Graduate Studies in Chemistry, Central College City Campus, Bangalore University, Bangalore, India
J Hazard Mater 164:459-67. 2009..of various reaction parameters like effect of iron dosage, concentration of H(2)O(2)/ammonium per sulfate (APS), initial dye concentration, effect of pH and the influence of radical scavenger are studied and optimum conditions ..
- Autoantibodies against phosphatidylserine, prothrombin and phosphatidylserine-prothrombin complex: identical or distinct diagnostic tools for antiphospholipid syndrome?Troy D Jaskowski
Associated Regional and University Pathologists ARUP Institute for Clinical and Experimental Pathology, University of Utah School of Medicine, Salt Lake City, UT, United States
Clin Chim Acta 410:19-24. 2009To clarify the association and diagnostic utility of measuring antiphosphatidyl serine (aPS), antiprothrombin (aPT) and the antiphosphatidyl serine/prothrombin complex (aPS/PT) antibodies in patients with antiphospholipid syndrome (APS) ..
- [Severe neurological and obstetrical complications in a patient with antiphospholipid syndrome]Danuta Bobrowska-Snarska
Klinika Reumatologii Pomorskiej AM w Szczecinie
Pol Arch Med Wewn 115:457-62. 2006Antiphospholipd syndrome (APS) is a disease characterised by venous and arterial thrombosis or recurrent foetal loss, which are associated with antiphospholipid antibodies or/and lupus anticoagulant...
- Homology modeling of dissimilatory APS reductases (AprBA) of sulfur-oxidizing and sulfate-reducing prokaryotesBirte Meyer
Max Planck Institute for Marine Microbiology, Bremen, Germany
PLoS ONE 3:e1514. 2008The dissimilatory adenosine-5'-phosphosulfate (APS) reductase (cofactors flavin adenine dinucleotide, FAD, and two [4Fe-4S] centers) catalyzes the transformation of APS to sulfite and AMP in sulfate-reducing prokaryotes (SRP); in sulfur-..
- Calcium dynamics associated with action potentials in single nerve terminals of pyramidal cells in layer 2/3 of the young rat neocortexH J Koester
Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Jahnstrasse 29, D 69120 Heidelberg, Germany
J Physiol 529:625-46. 2000..Single APs and trains of APs reliably evoked Ca2+ transients in en passant boutons located on axon collaterals in cortical ..
- Specificity and sensitivity of anti-beta2-glycoprotein I as compared with anticardiolipin antibody and lupus anticoagulant in Thai systemic lupus erythematosus patients with clinical features of antiphospholipid syndromeVirunya Parkpian
Division of Allergy, Immunology and Rheumatology, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
Clin Rheumatol 26:1663-70. 2007..I (anti-beta(2)-GPI) have been reported to have stronger association with clinical antiphospholipid syndrome (APS) than anticardiolipin antibodies (aCL) and lupus anticoagulant (LAC)...
- Radiofrequency catheter ablation of right atriofascicular (Mahaim) accessory pathways guided by accessory pathway activation potentialsJ H McClelland
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190
Circulation 89:2655-66. 1994BACKGROUND: Accessory pathways (APs) exhibiting "Mahaim fiber" physiology (antegrade conduction only, long conduction time, and decremental properties) often connect the lateral right atrium to the right bundle branch (right ..
- Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domainsEric B Lansdon
Department of Chemistry and Section of Molecular and Cellular Biology, University of California, One Shields Avenue, Davis, California 95616, USA
Biochemistry 43:4356-65. 2004..with each 71 kDa subunit containing an adenosine triphosphate (ATP) sulfurylase and an adenosine 5'-phosphosulfate (APS) kinase domain, catalyzes the overall formation of PAPS from ATP and inorganic sulfate...
- The use of portable computer for information acquirement during anesthesiologist's ward round in acute pain serviceYung Lung Lee
Department of Anesthesiology, Changhua Christian Hospital, Taiwan, ROC
Acta Anaesthesiol Taiwan 45:79-87. 2007..This study was to evaluate the use of PDA for acute pain assessment and compare the PDA-based method with that of the current paper-transcription method in work efficiency...
- [Ocular manifestations in patients with systemic lupus erythematosus and antiphospholipid syndrome]Lidia Ostanek
Klinika Reumatologii, Pomorska Akademia Medyczna, Szczecin
Pol Arch Med Wewn 117:18-23. 2007..It could be the reason for many organs and tissues impairment. Changes in eyes that occurr in SLE are not frequent, but can lead to severe impairment of sight including blindness...
- The HELLP syndrome in the antiphospholipid syndrome: retrospective study of 16 cases in 15 womenD Le Thi Thuong
Departments of Internal Medicine, Groupe Hospitalier Pitie Salpetriere, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13, France
Ann Rheum Dis 64:273-8. 2005To study the characteristics of the haemolysis, elevated liver enzymes, low platelets (HELLP) syndrome in the antiphospholipid syndrome (APS) and its influence on the subsequent pregnancies.
- Laboratory testing for the antiphospholipid syndrome: making sense of antiphospholipid antibody assaysEmmanuel J Favaloro
Department of Haematology, Institute of Clinical Pathology and Medical Research ICPMR, Westmead Hospital, NSW, Australia
Clin Chem Lab Med 49:447-61. 2011The antiphospholipid syndrome (APS) is an autoimmune condition characterised by a wide range of clinical features (primarily thrombosis and/or obstetric related), associated with the presence of antiphospholipid antibodies (aPL) as ..
- Identification of a second lipopolysaccharide in Porphyromonas gingivalis W50Minnie Rangarajan
Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London Queen Mary s School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, United Kingdom
J Bacteriol 190:2920-32. 2008We previously described a cell surface anionic polysaccharide (APS) in Porphyromonas gingivalis that is required for cell integrity and serum resistance...
- Novel sequence variation of AIRE and detection of interferon-omega antibodies in early infancyBeáta Tóth
Department of Infectious and Pediatric Immunology, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
Clin Endocrinol (Oxf) 72:641-7. 2010Autoimmune polyendocrine syndrome type I (APS I) is a rare primary immunodeficiency disorder characterized by chronic mucocutaneous candidiasis, multi-organ autoimmunity and ectodermal dysplasia...
- A peptide that shares similarity with bacterial antigens reverses thrombogenic properties of antiphospholipid antibodies in vivoSilvia S Pierangeli
Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Dr SW, Rm 331 BSMB, Atlanta, GA 30310 1495, USA
J Autoimmun 22:217-25. 2004..Peptide A is also found in region I/II of beta2GPI. A scrambled form of peptide A (named scA, GTKGCPNVRLT) was used as a control...
- Polysaccharides from Astragalus membranaceus promote phagocytosis and superoxide anion (O2-) production by coelomocytes from sea cucumber Apostichopus japonicus in vitroYongxin Sun
Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian, 116024, People s Republic of China
Comp Biochem Physiol C Toxicol Pharmacol 147:293-8. 2008The potential immunostimulatory effects of Astralagus membranaceus polysaccharides (APS) on sea cucumber, Apostichopus japonicus (Selenka), were investigated in vitro...
- Increased platelet deposition on extracellular matrix under flow conditions in patients with antiphospholipid syndrome who experience thrombotic eventsYair Levy
Meir Medical Center, Kfar Saba, Israel
Arthritis Rheum 52:4011-7. 2005To assess platelet function under defined flow conditions in patients with antiphospholipid syndrome (APS) and to correlate the results with thrombotic complications and the presence of subsets of antiphospholipid antibodies (aPL), lupus ..
- Sulfate-activating enzymes of Penicillium chrysogenum. The ATP sulfurylase.adenosine 5'-phosphosulfate complex does not serve as a substrate for adenosine 5'-phosphosulfate kinaseF Renosto
Department of Biochemistry and Biophysics, University of California, Davis 95616
J Biol Chem 264:9433-7. 1989At a noninhibitory steady state concentration of adenosine 5'-phosphosulfate (APS), increasing the concentration of Penicillium chrysogenum ATP sulfurylase drives the rate of the APS kinase-catalyzed reaction toward zero...
- Phase relation changes between the firings of alpha and gamma-motoneurons and muscle spindle afferents in the sacral micturition centre during continence functions in brain-dead human and patients with spinal cord injuryG Schalow
Electromyogr Clin Neurophysiol 50:3-27. 20101. Single-nerve fibre action potentials (APs) were recorded with 2 pairs of wire electrodes from lower sacral nerve roots during surgery in patients with spinal cord injury and in a brain-dead human...
- [Effects of Astragalus polysaccharides and Cordyceps sinensis mycelium mixture on the transforming growth factor-beta1 expression in chronic rejection of artery transplantation: experiment with rats]Song Zhao
Department of General Surgery, First Affiliated Hospital, Harbin Medical University, Heilongjiang Province, Harbin 150001, China
Zhonghua Yi Xue Za Zhi 87:851-4. 2007To explore the effect of Astragalus polysaccharides (APS) and Cordyceps sinensis (CP) mycelium mixture on the chronic rejection of artery transplantation.
- ATP sulfurylase from filamentous fungi: which sulfonucleotide is the true allosteric effector?I MacRae
Section of Molecular and Cellular Biology, University of California, Davis 95616, USA
Arch Biochem Biophys 337:17-26. 1997..inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS), the product of adenosine 5'-phosphosulfate (APS) kinase, the second enzyme in the sulfate activation sequence...
- The antiphospholipid syndrome in pregnant rabbits and their offspring. Neuropathological aspectsPrzemysław Nowacki
Department of Neurology, Pomeranian Medical University, Szczecin, Poland
Folia Neuropathol 43:15-22. 2005Although the obstetric consequences of antiphospholipid syndrome (APS) in pregnant rabbits have been described, there are no data on the serological and neuropathological aspects of the syndrome in their offspring...
- Evoked potential studies in the antiphospholipid syndrome: differential diagnosis from multiple sclerosisD Paran
Department of Rheumatology, Tel Aviv Sourasky Medical Centre, Sackler Faculty of Medicine, Tel Aviv University, Israel
Ann Rheum Dis 65:525-8. 2006The CNS manifestations of the antiphospholipid syndrome (APS) can mimic multiple sclerosis both clinically and radiologically.
- Protective effects of emodin and astragalus polysaccharides on chronic hepatic injury in ratsShuang Suo Dang
Department of Infectious Diseases, The Second Hospital of Xi an Jiaotong University, Xi an, Shaanxi, China
Chin Med J (Engl) 121:1010-4. 2008Chinese medicine plays an important role in hepatoprotective treatment. This study was conducted to investigate the protective effects of emodin and astragalus polysaccharides (APS) in a rat model of chronic hepatic injury.
- Antiphospholipid syndrome nephropathy in patients with systemic lupus erythematosus and antiphospholipid antibodies: prevalence, clinical associations, and long-term outcomeMaria G Tektonidou
Department of Pathophysiology, School of Medicine, National University of Athens, Athens, Greece
Arthritis Rheum 50:2569-79. 2004To evaluate the prevalence, clinical associations, and outcome of antiphospholipid syndrome (APS) nephropathy in patients with systemic lupus erythematosus (SLE) and antiphospholipid antibodies (aPL) and in SLE patients without aPL.
- A novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathwayW Cao
Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, 169 West Changle Road, Xi an, Shaanxi 710032, China
Phytomedicine 17:598-605. 2010A novel polysaccharide isolated from Angelica sinensis, named APS-1d showed cytotoxic activity towards several cancer cell lines in vitro. However, the precise antitumor mechanisms of this compound are unknown...
- A cost-utility and cost-effectiveness analysis of an acute pain serviceMichaela Stadler
Department of Anesthesiology, University Hospital Center, Charleroi, Belgium
J Clin Anesth 16:159-67. 2004To analyze, from a societal perspective, the cost-effectiveness and cost-utility of acute pain management after inception of a nurse-based Acute Pain Service (APS) in a general hospital.
- An acute pain service improves postoperative pain management for children undergoing selective dorsal rhizotomyChantal Frigon
Department of Anesthesiology, McGill University Health Center, Montreal Children s Hospital, Montreal, QC, Canada
Paediatr Anaesth 19:1213-9. 2009..The aim of the study was to evaluate the impact of having an organized acute pain service (APS) on postoperative pain management of these children.
- Circulating levels of tissue factor and proinflammatory cytokines in patients with primary antiphospholipid syndrome or leprosy related antiphospholipid antibodiesR R Forastiero
Favaloro University, Favaloro Foundation, Buenos Aires, Argentina
Lupus 14:129-36. 2005The antiphospholipid syndrome (APS) is characterized by the presence of antiphospholipid antibodies (aPL) in patients with thromboembolic complications...
- The isolation and characterization of cDNA encoding the mouse bifunctional ATP sulfurylase-adenosine 5'-phosphosulfate kinaseH Li
Department of Pediatrics, University of Chicago, Illinois 60637, USA
J Biol Chem 270:29453-9. 1995..action of two enzyme activities: ATP sulfurylase, which catalyzes the formation of adenosine 5'-phosphosulfate (APS) from ATP and free sulfate, and APS kinase, which subsequently phosphorylates APS to produce adenosine 3'-phosphate ..
- Ligand-induced structural changes in adenosine 5'-phosphosulfate kinase from Penicillium chrysogenumEric B Lansdon
Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA
Biochemistry 41:13672-80. 2002Adenosine 5'-phosphosulfate (APS) kinase catalyzes the second reaction in the two-step, ATP-dependent conversion of inorganic sulfate to 3'-phosphoadenosine 5'-phosphosulfate (PAPS)...
- Clusters of disease manifestations in patients with antiphospholipid syndrome demonstrated by factor analysisI Krause
Department of Medicine E, Rabin Medical Center, Beilinson Campus, Israel
Lupus 16:176-80. 2007The antiphospholipid syndrome (APS) is now recognized as a multi-system disease, the clinical expression of which may include various target-organs involvements...
- Astragalus polysaccharides: an effective treatment for diabetes prevention in NOD miceW Chen
Department of Geriatrics, Huashan Hospital, Fudan University of Shangai, China
Exp Clin Endocrinol Diabetes 116:468-74. 2008..Astragalus polysaccharides (APS) are bioactive components extracted from one of the traditional Chinese herbs, used to enhance the function of ..
- Arterialisation of the portal vein as a model for the induction of hepatic fibrosis: description of microsurgical models in the ratVolker Muller
Department of Surgery, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
Transpl Int 17:822-33. 2005..inserted in the right renal artery (PVA-B), the second with unrestricted flow using an aortic-portal segment (PVA-APS). The third technique was orthotopic liver transplantation with unrestricted portal arterialisation (OLTx-APS)...
- Factor XIII in primary antiphospholipid syndromePaul R J Ames
Academic Department of Rheumatology, Leeds General Infirmary, Leeds, UK
J Rheumatol 32:1058-62. 2005To evaluate the clinical significance of factor XIII (FXIII) in primary antiphospholipid syndrome (APS).
- Novel autoantibodies against the activated coagulation factor IX (FIXa) in the antiphospholipid syndrome that interpose the FIXa regulation by antithrombinYao Hsu Yang
Division of Rheumatology, Department of Medicine, University of California, Los Angeles, CA 90095, USA
J Immunol 182:1674-80. 2009We previously reported that some human antiphospholipid Abs (aPL) in patients with the antiphospholipid syndrome (APS) bind to the homologous enzymatic domains of thrombin and the activated coagulation factor X (FXa)...
- Modulation of Ca(2+)-activated K+ currents and Ca(2+)-dependent action potentials by exocytosis in goldfish bipolar cell terminalsMary J Palmer
Neuroscience Group, Institute for Science and Technology in Medicine, Keele University, Keele ST5 5BG, UK
J Physiol 572:747-62. 2006..They do not fire Na(+)-dependent action potentials (APs) but the Mb1 class of goldfish bipolar cell exhibits Ca(2+)-dependent APs and regenerative potentials that ..
- Use of a new silica clotting time for diagnosing lupus anticoagulant in patients who meet the clinical criteria for antiphospholipid syndromePanagiotis Grypiotis
Rheumatology Unit, University of Padova, Padova, Italy
J Clin Lab Anal 20:15-8. 2006..a new commercial SCT for identifying LA in patients who meet the clinical criteria for antiphospholipid syndrome (APS), and its association with thrombotic events were evaluated here...
- Oligonucleotide model with non-identical complementary strands for chromatographic studies of structure-dependent photosusceptibilityV N Potaman
Department of Biology, George Mason University, Fairfax, VA 22030
J Chromatogr A 690:65-70. 1995..F6 and the ordinary antiparallel-stranded (aps) F5.F7 duplexes...
- Moderate/severe erectile dysfunction in patients with antiphospholipid syndromeA Lopes Gallinaro
Rheumatology Division, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Brazil
Lupus 21:319-23. 2012To evaluate sexual function of antiphospholipid syndrome (APS) patients using the Brazilian version of the validated International Index of Erectile Function (IIEF).
- Thrombotic microangiopathy due to multiple autoantibodies related to antiphospholipid syndromeShunsuke Noda
Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo 157 8535, Japan
Pediatr Nephrol 27:681-5. 2012Antiphospholipid syndrome (APS) is a rare disorder in children. More than half of childhood APS occurs as secondary APS complicated by systemic lupus erythematosus (SLE) and other autoimmune diseases...
- Renal involvement in the antiphospholipid syndrome (APS)-APS nephropathyMaria G Tektonidou
Department of Pathophysiology, School of Medicine, National University of Athens, Athens, Greece
Clin Rev Allergy Immunol 36:131-40. 2009Although the kidney represents a major target organ in antiphospholipid syndrome (APS), renal involvement in APS was poorly recognized until recently...
- [Classification and clinical analysis of 165 patients with antiphospholipid syndrome.]Na Xu
Department of Rheumatology Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100032, China Email
Zhonghua Nei Ke Za Zhi 48:904-7. 2009Based on 2006 revised classification criteria of definite antiphospholipid syndrome (APS) and definition of new APS subsets, we investigated clinical features of APS patients, correlation between thrombotic events and related antibodies ..
- Factor XIII-A subunit Val34Leu polymorphism is associated with the risk of thrombosis in patients with antiphospholipid antibodies and high fibrinogen levelsGloria de la Red
Department of Hemotherapy and Hemostasis, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
Thromb Haemost 101:312-6. 2009..We included 172 consecutive patients with aPL: 88 with primary antiphospholipid syndrome (APS), 38 with APS associated with systemic lupus erythematosus (APS-SLE), 32 with SLE and aPL but without APS (SLE-aPL),..
- High levels of NK cells in the peripheral blood of patients affected with anti-phospholipid syndrome and recurrent spontaneous abortion: a potential new hypothesisC Perricone
Department of Rheumatology, University of Rome Tor Vergata, Rome, Italy
Rheumatology (Oxford) 46:1574-8. 2007No data regarding phenotypic assets of circulating lymphocytes in anti-phospholipid syndrome (APS) are reported in the literature...
- Crystal structure of Saccharomyces cerevisiae 3'-phosphoadenosine-5'-phosphosulfate reductase complexed with adenosine 3',5'-bisphosphateZhihao Yu
Departments of Chemistry and Molecular and Cellular Biology, University of California, Davis, One Shields Avenue, Davis, California 95616
Biochemistry 47:12777-86. 2008Most assimilatory bacteria, fungi, and plants species reduce sulfate (in the activated form of APS or PAPS) to produce reduced sulfur. In yeast, PAPS reductase reduces PAPS to sulfite and PAP...
- First clinical experience with the automatic positioning system and Leksell gamma knife Model C. Technical noteG A Horstmann
Gamma Knife Zentrum, Krefeld, Germany
J Neurosurg 93:193-7. 2000..During the same period the new automatic positioning system (APS) was extensively tested and refined so that the first APS treatment could be performed in January 2000...
- The 4G/5G polymorphism of the type 1 plasminogen activator inhibitor gene and thrombosis in patients with antiphospholipid syndromeD Tassies
Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
Arthritis Rheum 43:2349-58. 2000To investigate the relationship between the 4G/5G polymorphism of the type 1 plasminogen activator inhibitor (PAI-1) gene and thrombotic manifestations in patients with antiphospholipid syndrome (APS).
- Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteinsM Iseki
Department of Immunology, Institute of Medical Science, University of Tokyo, Japan
Biochem Biophys Res Commun 272:45-54. 2000..We tried to identify another member of the adaptor protein family and isolated the mouse APS (adaptor molecule containing PH and SH2 domains)...
- Evaluation of anticoagulation in patients with antiphospholipid syndromeKathleen E Horner
Department of Pharmaceutical Care, University of Iowa Hospitals and Clinics UIHC, Iowa City, IA 52242, USA
Am J Health Syst Pharm 65:964-7. 2008The quality of anticoagulation therapy in patients with antiphospholipid syndrome (APS) was evaluated.
- Antiphospholipid syndrome (APS) nephropathy in catastrophic, primary, and systemic lupus erythematosus-related APSMaria G Tektonidou
Department of Pathophysiology, School of Medicine, National University of Athens, and Rheumatology Department, Euroclinic Hospital, Athens, Greece
J Rheumatol 35:1983-8. 2008Renal involvement in antiphospholipid syndrome (APS) has been poorly recognized...
- Toll-like receptor and antiphospholipid mediated thrombosis: in vivo studiesSilvia S Pierangeli
Antiphospholipid Standardization Laboratory, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 1165, USA
Ann Rheum Dis 66:1327-33. 2007..to investigate the in vivo pathogenic role of Toll-like receptor 4 (TLR-4) in the antiphospholipid syndrome (APS) by studying the thrombogenic antiphospholipid (aPL) activity in lipopolysaccharide (LPS) non-responsive (LPS-/-) ..
- Synthesis and antitumor evaluation of 2,5-disubstituted-indazolo[4, 3-gh]isoquinolin-6(2H)-ones (9-aza-anthrapyrazoles)A P Krapcho
Departments of Chemistry and Pharmacology, University of Vermont, Burlington, Vermont 05405, USA
J Med Chem 41:5429-44. 1998The synthesis and antitumor evaluation of 2, 5-disubstituted-indazolo[4,3-gh]isoquinolin-6(2H)-ones (9-aza-APs) are described...
- Deletion and site-directed mutagenesis of the ATP-binding motif (P-loop) in the bifunctional murine ATP-sulfurylase/adenosine 5'-phosphosulfate kinase enzymeA T Deyrup
Department of Pediatrics, The University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 273:9450-6. 1998..The recently cloned murine ATP-sulfurylase/adenosine 5'-phosphosulfate (APS) kinase contains a P-loop (residues 59-66) in the APS kinase portion of the bifunctional protein...
- Insulin increase in MAP kinase phosphorylation is shifted to early time-points by overexpressing APS, while Akt phosphorylation is not influencedSheela Onnockx
Institute of Interdisciplinary Research IRIBHM, School of Medicine, Universite Libre de Bruxelles, Campus Erasme, Route de Lennik 808, Brussels, Belgium
Exp Cell Res 315:2479-86. 2009Upon insulin stimulation, the adaptor protein APS is recruited to the insulin receptor and tyrosine phosphorylated. APS initiates the insulin-induced TC10 cascade which participates to GLUT4 translocation to the plasma membrane...
- Astragalus mongholicus polysaccharide inhibits lipopolysaccharide-induced production of TNF-alpha and interleukin-8Yuan Yuan
Department of Pediatrics, Shengjing Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
World J Gastroenterol 15:3676-80. 2009To explore the effect of Astragalus mongholicus polysaccharide (APS) on gene expression and mitogen-activated protein kinase (MAPK) transcriptional activity in intestinal epithelial cells (IEC).
- [Diverse histological lesions in a patient with antiphospholipid syndrome (APS)]Ermanno Salvatore
UOC Nefrologia e Dialisi AORN G Rummo, Benevento, Italy
G Ital Nefrol 28:537-40. 2011Antiphospholipid syndrome (APS) is a rare autoimmune disorder. It can be secondary to systemic lupus erythematosus (SLE) or occur in the absence of autoimmune disease...
- Towards multimodal HPLC separations on humic acid-bonded aminopropyl silica: RPLC and LEC behaviorOrhan Gezici
Nigde University, Faculty of Science and Arts, Chemistry Department, 51100, Nigde, Turkey
Talanta 85:2405-10. 2011..Humic-acid bonded aminopropyl silica (EC-HA-APS) was turned into ligand exchanger forms by loading aqueous solutions of Cu(2+), and Co(2+) to the column (4...
- The avidity of anti-beta2-glycoprotein I antibodies in patients with or without antiphospholipid syndrome: a collaborative study in the frame of the European forum on antiphospholipid antibodiesS Cucnik
University Medical Centre, Department of Rheumatology, Ljubljana, Slovenia
Lupus 20:1166-71. 2011..I antibodies (anti-β2-GPI) on a larger group of patients with primary or secondary antiphospholipid syndrome (APS) and anti-β2-GPI positive patients without APS in the frame of the European Forum on antiphospholipid antibodies (..
- Astragalus polysaccharides attenuate postburn sepsis via inhibiting negative immunoregulation of CD4+ CD25(high) T cellsQing Yang Liu
Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing, People s Republic of China
PLoS ONE 6:e19811. 2011Astragalus polysaccharides (APS) isolated from one of the Chinese herbs, Astragalus mongholicus, are known to have a variety of immunomodulatory activities...
- Comparison of the SidePak personal monitor with the Aerosol Particle Sizer (APS)Araceli Sánchez Jiménez
Institute of Occupational Medicine, Edinburgh, United Kingdom
J Environ Monit 13:1841-6. 2011The aim of this study was to compare the performance of the TSI Aerodynamic Particle Sizer (APS) and the TSI portable photometer SidePak to measure airborne oil mist particulate matter (PM) with aerodynamic diameters below 10 μm, 2...
- Autoimmune polyglandular syndrome type 2 shows the same HLA class II pattern as type 1 diabetesC Weinstock
German Red Cross Blood Service West, Hagen, Germany
Tissue Antigens 77:317-24. 2011Autoimmune polyglandular syndrome (APS) type 2 is defined by the manifestation of at least two autoimmune endocrine diseases. Only few data exist on genetic associations of APS type 2...
- The effects of anticholinesterases on the latencies of action potentials in mouse skeletal musclesS S Kelly
Pharmacological Laboratories, Pharmaceutical Sciences Institute, Aston University, Birmingham
Br J Pharmacol 99:721-6. 1990..2. Action potentials (APs), elicited by stimulation of the phrenic nerve, were recorded intracellularly in muscle fibres of mouse diaphragm...
- [Autoimmune polyendocrine syndrome type 2 associated with autoimmune hypophysitis and coeliac disease]K Hrubisková
V Interná klinika Lekárskej fakulty UK a FNsP Bratislava, Slovenska republika
Vnitr Lek 56:1169-76. 2010Autoimmune polyendocrine syndromes (APS) are organ-specific autoimmune disorders affecting multiple endocrine glands; these are gradually destroyed by action of autoantibodies...
- Abbey Pain Scale: development and validation of the Japanese versionYukari Takai
Department of Gerontological Nursing, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan
Geriatr Gerontol Int 10:145-53. 2010The purpose of this study was to develop and validate the Japanese version of the Abbey Pain Scale (APS-J), to assess pain of older adults who live in nursing homes in Japan.
- Autoimmune polyglandular syndrome type 1 in Russian patients: clinical variants and autoimmune regulator mutationsElizaveta M Orlova
Endocrinology Research Centre, Institute of Paediatric Endocrinology, Moscow, Russia elizaveta orlova mail ru
Horm Res Paediatr 73:449-57. 2010Autoimmune polyglandular syndrome type 1 (APS-1) (OMIM 240300) is a rare autosomal recessive disorder associated with three major manifestations: chronic mucocutaneous candidiasis, hypoparathyroidism, and adrenal insufficiency...
- Oxidation of the diphosphoinositol polyphosphate phosphohydrolase-like Nudix hydrolase Aps from Drosophila melanogaster induces thermolability--A possible regulatory switch?Lucinda Winward
Division of Cell Signalling, University of Dundee, Dow Street, Dundee DD1 4HN, United Kingdom
Int J Biochem Cell Biol 42:1174-81. 2010..In order to evaluate its function, Aps was cloned and characterized...
- Evidence that actomyosin cross bridges contribute to "passive" tension in detrusor smooth musclePaul H Ratz
Departments of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0614, USA
Am J Physiol Renal Physiol 298:F1424-35. 2010..smooth muscle (DSM) at short muscle lengths generates a stiffness component we termed adjustable passive stiffness (APS) that is retained in tissues incubated in a Ca(2+)-free solution, shifts the DSM length-passive tension curve up ..
- Comparison of the 1999 Sapporo and 2006 revised criteria for the classification of the antiphospholipid syndromeC Solano
Department of Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
Clin Exp Rheumatol 27:914-9. 2009The 2006 revised criteria for antiphospholipid syndrome (APS) provide a new classification challenge, and studies validating the updated criteria against the older ones are still scanty...
- [Components of hair bleaches as triggers of bronchial hypersensitivity--studies using a model for occupationally-induced lung damage]T Mensing
Pneumologie 49:418-27. 1995Ammonium persulfate (APS) is used as an oxidant in many industrial branches and is contained in bleaching substances used in hair cosmetic industry. In addition to skin diseases, respiratory disorders have been frequently reported...
- Pregnancy outcome in different clinical phenotypes of antiphospholipid syndromeK Bramham
Department of Maternal Medicine, Women s services directorate and Lupus Unit, Guy s and St Thomas NHS Foundation Trust, London, UK
Lupus 19:58-64. 2010Women with antiphospholipid syndrome (APS) may have diverse pregnancy outcomes. The objective of this study was to evaluate pregnancy outcome in women with APS according to their clinical phenotype, i.e. thrombotic and obstetric APS...
- Intermediate channeling between ATP sulfurylase and adenosine 5'-phosphosulfate kinase from rat chondrosarcomaS Lyle
Department of Pediatrics, University of Chicago, Illinois 60637
Biochemistry 33:6822-7. 1994..ATP sulfurylase catalyzes the formation of APS (adenosine 5'-phosphosulfate) from ATP and free sulfate, and APS is then phosphorylated by APS kinase to produce ..
- Astragalus polysaccharide improves insulin sensitivity in KKAy mice: regulation of PKB/GLUT4 signaling in skeletal muscleMin Liu
Department of Pathophysiology, Medical College of Wuhan University, Hubei Provincial Key Laboratory of Allergy and Immune Related Diseases, Wuhan 430071, China
J Ethnopharmacol 127:32-7. 2010Astragalus polysaccharide (APS) is an important bioactive component of Astragalus membranaceus Bunge (Leguminosae) that has been used in traditional Chinese medicine for treating diabetes.
- Antiphospholipid antibodies and migraine: a retrospective study of 428 patients with inflammatory connective tissue diseasesR Tanasescu
Carol Davila University of Medicine and Pharmacy, Department of Neurology, Colentina Hospital, Bucharest, Romania
Rom J Intern Med 45:355-63. 2007The antiphospholipid syndrome (APS) is defined by the presence of antiphospholipid antibodies (aPL), associated with thrombosis or recurrent spontaneous abortions...
- Single center review of clinicopathological characterization in 77 patients with positive lupus anticoagulant antibodiesTarek M Owaidah
Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, P O Box 11211, Riyadh, Kingdom of Saudi Arabia
Hematology 8:249-57. 2003The antiphospholipid syndrome (APS) is a thrombophillic disorder characterized by the presence of antiphospholipid antibodies (APA)...
- Clinical manifestations and antiphosphatidylserine antibodies in patients with systemic lupus erythematosus: is there an association?Mehmet Sahin
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
Clin Rheumatol 26:154-60. 2007..autoantibodies which have been reported in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) in association with thrombosis, fetal loss, and thrombocytopenia...
- Do patients followed in anticoagulation clinics for antiphospholipid syndrome meet criteria for the disorder?Andrew S Dunn
Division of General Medicine, Mount Sinai School of Medicine, 1470 Madison Ave, Box 1087, New York, NY 10029, USA
Thromb Haemost 94:548-54. 2005Although specific criteria for diagnosing the antiphospholipid syndrome (APS) exist (the Sapporo Criteria), most physicians are not aware these include repeat testing and documentation of either a lupus anticoagulant or medium to high ..
- SH2-B family members differentially regulate JAK family tyrosine kinasesKaren B O'Brien
Department of Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0622, USA
J Biol Chem 277:8673-81. 2002..However, SH2-B beta bound to both and was tyrosyl-phosphorylated by JAK1. In contrast to SH2-B beta, APS decreased tyrosyl phosphorylation of GH-stimulated JAK2 as well as Stat5B, a substrate of JAK2...
Research Grants106 found, 100 shown here
- Reduction of Annexin A5 in Antiphospholipid Pregnancy LossJACOB RAND; Fiscal Year: 2007Recurrent pregnancy losses are a hallmark of the antiphospholipid syndrome (APS), a complicated major hypercoagulable disorder without an established mechanism that is currently diagnosed with phenomenologic surrogate tests...
- Antimicrobial Peptides and Innate Immunity in Otitis MediaLAUREN BAKALETZ; Fiscal Year: 2009..Antimicrobial peptides (APs) are key components of the innate immune system, providing first-line inactivation of microbes on the vast ..
- Excitation-contraction Coupling in Normal and Dystrophic Mammalian MuscleJulio L Vergara; Fiscal Year: 2010..We have found that Ca2+ release evoked by action potentials (APs) (or voltage-clamp pulses) in muscle fibers from two of such models, the adult mdx mouse and the phenotypic ..
- Predictors of Pregnancy Outcome in SLE and APSJane Salmon; Fiscal Year: 2009Pregnancy complications in women with the antiphospholipid syndrome (APS) and/or SLE include recurrent miscarriage, preeclampsia, placental insufficiency, and intrauterine growth restriction (IUGR)...
- Predictors of Pregnancy Outcome in SLE and APSJane E Salmon; Fiscal Year: 2010Pregnancy complications in women with the antiphospholipid syndrome (APS) and/or SLE include recurrent miscarriage, preeclampsia, placental insufficiency, and intrauterine growth restriction (IUGR)...
- ANTICARDIOLIPIN ANTIBODIES AND OXIDIZED PHOSPHOLIPIDSJoseph Witztum; Fiscal Year: 2004Patients with the antiphospholipid antibody syndrome (APS) have autoantibodies to certain phospholipids (aPL) such as cardiolipin and/or the lupus anticoagulant and clinically experience recurrent venous or arterial thrombosis, history ..
- ANTICARDIOLIPIN ANTIBODIES AND OXIDIZED PHOSPHOLIPIDSJoseph Witztum; Fiscal Year: 2000DESCRIPTION (Adapted from Investigator's Abstract): Patients with the antiphospholipid syndrome (APS) have autoantibodies to certain phospholipids such as cardiolipin and/or the lupus anticoagulant and clinically experience recurrent ..
- THERAPY WITH ANNEXINS FOR ANTIPHOSPHOLIPID SYNDROMEMARIA BEGONA CAMPOS NACIFF; Fiscal Year: 2004DESCRIPTION: (Scanned from the applicant's description): APS is a disorder characterized by venous and arterial thrombosis, recurrent fetal loss, thrombocytopenia and by the presence of antiphospholipid antibodies...
- Predictors of Pregnancy Outcome in SLE and APSJane Salmon; Fiscal Year: 2007..Our studies in a murine model of antiphospholipid antibody syndrome (APS) indicate that in vivo complement activation is necessary for fetal loss caused by aPL antibodies...
- AUTOIMMUNE MECHANISMS OF THROMBOSISRobert Roubey; Fiscal Year: 2004The Antiphospholipid Syndrome (APS) represents an interface between the immune system and blood coagulation...
- TREATMENT STRATEGIES FOR THE ANTI PHOSPHOLIPID SYNDROMEJOHN DEDMAN; Fiscal Year: 2003Antiphospholipid Syndrome (APS), also known as Hughes Syndrome, is a multiorgan vascular disease associated with myocardial infarction, stroke thrombosis and recurrent fetal loss...
- ANTICARDIOLIPIN ANTIBODIES IN ANTIPHOSPHOLIPID SYNDROMEPojen Chen; Fiscal Year: 2007..are to identify and characterize pathogenic anticardiolipin antibodies (aCL) in the antiphospholipid syndrome (APS)...
- Regulation of the anti-phospholipid response in SLEAnne Davidson; Fiscal Year: 2010..PUBLIC HEALTH RELEVANCE: Antiphospholipid syndrome (APS) is a devastating autoimmune condition that causes recurrent blood clots and has no effective treatment apart from ..
- Isolation of Autoantibodies to Apoptotic CellsMarko Radic; Fiscal Year: 2004..evidence links the initiation and progression of Systemic Lupus Erythematosus (SLE) and Anti-Phospholipid Syndrome (APS) to aberrant immune responses to apoptotic cells...
- Mechanism of aPL antibody-induced Pregnancy lossJane E Salmon; Fiscal Year: 2010The antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy loss that occur in the presence of antiphospholipid (aPL) antibodies...
- Mechanism of aPL antibody-induced Pregnancy lossJane Salmon; Fiscal Year: 2009The antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy loss that occur in the presence of antiphospholipid (aPL) antibodies...
- Mechanisms of aPL antibody-induced pregnancy lossJane Salmon; Fiscal Year: 2007The antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy loss that occur in the presence of antiphospholipid (aPL) antibodies...
- Reduction of Annexin A5 in Antipholipid Pregnancy LossJACOB RAND; Fiscal Year: 2010Recurrent pregnancy losses are a hallmark of the antiphospholipid syndrome (APS), a complicated major hypercoagulable disorder without an established mechanism that is currently diagnosed with phenomenologic surrogate tests...
- Pathophysiology of anti-B2GPI Antibodies in APSALISA WOLBERG; Fiscal Year: 2007..The prevalence of venous thrombosis associated with the primary Antiphospholipid Syndrome (APS) may be as high as 0...
- Factors that Initiate Arrhythamias in Long QT SyndromeGuy Salama; Fiscal Year: 2006..will be perfused, stained with voltage and Ca 2+ - sensitive dyes to simultaneously map action potentials (APs) and intracellular Ca 2v(Cai) transients from 256 sites at high spatial and temporal resolution...
- KALLIKREIN KININ SYSTEM IN INFLAMMATORY BOWEL DISEASERobert Colman; Fiscal Year: 2001We have shown that bacterial products (proteoglycan-polysaccharide, PG- APS) found in the lower bowel produce chronic granulomatous inflammation similar to Crohn's disease (regional ileitis) in genetically susceptible rats as well as ..
- Innate Immunity in Experimental Arthritis of KininogenRobert Colman; Fiscal Year: 2007..Parenterally injected peptidoglycanpolysaccharide complexes (PG-APS) induce a systemic inflammatory response consisting of erosive polyarthritis, hepatic granulomas, and anemia...
- Antiphospholipid antibodies and lupus: new molecular targets for treatmentSilvia S Pierangeli; Fiscal Year: 2010..thrombosis and pregnancy loss in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). Thrombosis is an important cause of morbidity and mortality in APS and SLE patients with aPL Abs...
- Gender-Differences in Cardiac Repolarization/ArrhythmiasGuy Salama; Fiscal Year: 2005..Optical maps of APs and Cai transients q selective blockers for IKr, IKs and ICa will elucidate gender differences in the spatial ..
- Factors that Initiate Arrhythmias in lung QT SyndromeGuy Salama; Fiscal Year: 2004..branches, will be perfused, stained with voltage and Ca2+ sensitive dyes to simultaneously map action potentials (APs) and intracellular Ca2+ (Ca1) transients from 256 sites at high spatial and temporal resolution...
- Antimicrobial Peptides and Innate Immunity in Otitis MediaLauren O Bakaletz; Fiscal Year: 2010..Antimicrobial peptides (APs) are key components of the innate immune system, providing first-line inactivation of microbes on the vast ..
- Haemophilus ducreyi Resistance to Antimicrobial PeptidesMARGARET BAUER; Fiscal Year: 2007..A key component of the innate immune response to pathogens is production of bactericidal antimicrobial peptides (APs)...
- Antimicrobial Peptides and Innate Immunity in Otitis MediaLAUREN BAKALETZ; Fiscal Year: 2009..Antimicrobial peptides (APs) are key components of the innate immune system, providing first-line inactivation of microbes on the vast ..
- MOLECULAR STUDIES OF SELECTIVE PROTEIN TRANSPORTGregory Payne; Fiscal Year: 1993..further define the function of clathrin coats in selective transport, genes encoding clathrin-associated proteins (APs) will be cloned and used to generate gene disruptions...
- GONOCOCCAL INFECTION AND GENE EXPRESSION IN FEMALE MICEAnn E Jerse; Fiscal Year: 2010..Purified cathepsin G (CG) and two antimicrobial peptides (APs) found within PMNs, LL37 and the bactericidal/permeability- increasing protein (BPI), kill Gc in vitro...
- Antimicrobial Peptides & Innate Immunity in Otitis MediaLAUREN BAKALETZ; Fiscal Year: 2006Antimicrobial polypeptides (APs) are key components of the primary defense mechanisms of mucus membranes, providing first-line inactivation of bacteria, fungi and viruses on the vast epithelial surfaces that line the respiratory, ..
- The Sexual Abuse of Vulnerable Adults in InstitutionsPamela Teaster; Fiscal Year: 2006In 2000, Adult Protective Services (APS), typically the state agency of first contact in cases of abuse, neglect, or exploitation, received 473,095 domestic (in the community) and institutional (nursing homes, assisted living, group ..
- Ultrasound-induced Thermal Strain Imaging for Arterial Plaque CharacterizationKang Kim; Fiscal Year: 2010..alternative imaging technique to non-invasively and reliably identify and characterize atherosclerotic plaques (APs)...