SH2B2

Summary

Gene Symbol: SH2B2
Description: SH2B adaptor protein 2
Alias: APS, SH2 and PH domain-containing adapter protein APS, SH2B adapter protein 2, adapter protein with pleckstrin homology and Src homology 2 domains, adaptor protein with pleckstrin homology and src homology 2 domains
Species: human

Top Publications

  1. ncbi Adenosine-5'-phosphosulfate kinase from Penicillium chrysogenum: ligand binding properties and the mechanism of substrate inhibition
    F Renosto
    Department of Biochemistry and Biophysics, University of California, Davis 95616
    Arch Biochem Biophys 284:30-4. 1991
  2. ncbi [Comparison of the characteristics of methacholine and of propranolol in the assessment of aspecific hyperreactivity of the airways]
    G Schultze-Werninghaus
    , Abt. f. Pneumologie, Frankfurt/Main
    Pneumologie 45:729-33. 1991
  3. ncbi ATP sulfurylase from higher plants: kinetic and structural characterization of the chloroplast and cytosol enzymes from spinach leaf
    F Renosto
    Department of Biochemistry and Biophysics, University of California, Davis 95616
    Arch Biochem Biophys 307:272-85. 1993
  4. ncbi Effect of valsartan on angiotensin II- and vasopressin-degrading activities in the kidney of normotensive and hypertensive rats
    I Prieto
    Unit of Physiology, , Bldg. B3, 23071, , Spain
    Horm Metab Res 33:559-63. 2001
  5. ncbi Artificial pulmonary surfactant as a carrier for intratracheally instilled insulin
    Ying Ji
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, China
    Acta Pharmacol Sin 28:744-50. 2007
  6. pmc Tachykinin NK1 but not NK2 receptors mediate non-cholinergic excitatory junction potentials in the circular muscle of guinea-pig colon
    V Zagorodnyuk
    Department Neuro muscular Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Br J Pharmacol 110:795-803. 1993
  7. ncbi In-hospital complications among survivors of admission for congestive heart failure, chronic obstructive pulmonary disease, or diabetes mellitus
    J M Geraci
    Houston Center for Quality of Care and Utilization Studies, Houston Veterans Affairs Medical Center, Baylor College of Medicine 77030, USA
    J Gen Intern Med 10:307-14. 1995
  8. ncbi Obesity and related metabolic abnormalities during antipsychotic drug administration: mechanisms, management and research perspectives
    T Baptista
    Los Andes University School of Medicine, Department of Physiology, Merida, Venezuela
    Pharmacopsychiatry 35:205-19. 2002
  9. ncbi Probing antiphospholipid-mediated thrombosis: the interplay between anticardiolipin antibodies and endothelial cells
    S S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia, USA
    Lupus 12:539-45. 2003
  10. doi Determinants of risk for venous and arterial thrombosis in primary antiphospholipid syndrome and in antiphospholipid syndrome with systemic lupus erythematosus
    Adriana Danowski
    Rheumatology Department, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 7500, Baltimore MD 21205, USA
    J Rheumatol 36:1195-9. 2009

Research Grants

Detail Information

Publications156 found, 100 shown here

  1. ncbi Adenosine-5'-phosphosulfate kinase from Penicillium chrysogenum: ligand binding properties and the mechanism of substrate inhibition
    F Renosto
    Department of Biochemistry and Biophysics, University of California, Davis 95616
    Arch Biochem Biophys 284:30-4. 1991
    35S]Adenosine-5'-phosphosulfate (APS) binding to Penicillium chrysogenum APS kinase was measured by centrifugal ultrafiltration...
  2. ncbi [Comparison of the characteristics of methacholine and of propranolol in the assessment of aspecific hyperreactivity of the airways]
    G Schultze-Werninghaus
    , Abt. f. Pneumologie, Frankfurt/Main
    Pneumologie 45:729-33. 1991
    ..The aerosol was administered by a dosimeter (APS, Jaeger), using doubling concentrations, with a maximum of 25 mg/ml (2.5%), the lowest concentrations being 0...
  3. ncbi ATP sulfurylase from higher plants: kinetic and structural characterization of the chloroplast and cytosol enzymes from spinach leaf
    F Renosto
    Department of Biochemistry and Biophysics, University of California, Davis 95616
    Arch Biochem Biophys 307:272-85. 1993
    ..03 +/- 0.01 adenosine-5'-phosphosulfate (APS) synthesis units x gram fresh weight-1)...
  4. ncbi Effect of valsartan on angiotensin II- and vasopressin-degrading activities in the kidney of normotensive and hypertensive rats
    I Prieto
    Unit of Physiology, , Bldg. B3, 23071, , Spain
    Horm Metab Res 33:559-63. 2001
    ..Given that aminopeptidases (APs) play a major role in the metabolism of local peptides involved in blood pressure control, studying them helped us ..
  5. ncbi Artificial pulmonary surfactant as a carrier for intratracheally instilled insulin
    Ying Ji
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, China
    Acta Pharmacol Sin 28:744-50. 2007
    ..bioavailabilities and effects on lung injury alleviation of 4 insulin- artificial pulmonary surfactant (INS-APS) preparations were studied in normal rats...
  6. pmc Tachykinin NK1 but not NK2 receptors mediate non-cholinergic excitatory junction potentials in the circular muscle of guinea-pig colon
    V Zagorodnyuk
    Department Neuro muscular Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Br J Pharmacol 110:795-803. 1993
    ..j.p.) followed by e.j.p. with superimposed action potentials (APs) and contraction. Addition of either NG-nitro-L-arginine (L-NOARG, 0.1 mM) or apamin (0...
  7. ncbi In-hospital complications among survivors of admission for congestive heart failure, chronic obstructive pulmonary disease, or diabetes mellitus
    J M Geraci
    Houston Center for Quality of Care and Utilization Studies, Houston Veterans Affairs Medical Center, Baylor College of Medicine 77030, USA
    J Gen Intern Med 10:307-14. 1995
    ..9%). Patient age, the presence of comorbid diseases, and the Acute Physiology Score (APS) of APACHE II were associated with complication occurrence...
  8. ncbi Obesity and related metabolic abnormalities during antipsychotic drug administration: mechanisms, management and research perspectives
    T Baptista
    Los Andes University School of Medicine, Department of Physiology, Merida, Venezuela
    Pharmacopsychiatry 35:205-19. 2002
    Excessive body weight gain (BWG) is a common side effect of some typical and atypical antipsychotic drugs (APs)...
  9. ncbi Probing antiphospholipid-mediated thrombosis: the interplay between anticardiolipin antibodies and endothelial cells
    S S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia, USA
    Lupus 12:539-45. 2003
    The association of antiphospholipid (aPL) antibodies with thrombosis in patients with antiphospholipid syndrome (APS) is well documented in humans and in animal studies...
  10. doi Determinants of risk for venous and arterial thrombosis in primary antiphospholipid syndrome and in antiphospholipid syndrome with systemic lupus erythematosus
    Adriana Danowski
    Rheumatology Department, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 7500, Baltimore MD 21205, USA
    J Rheumatol 36:1195-9. 2009
    Antiphospholipid syndrome (APS) is characterized by thrombosis (venous and arterial) and pregnancy loss in conjunction with the lupus anticoagulant, IgG or IgM anticardiolipin, or IgG or IgM anti-beta2-glycoprotein I...
  11. pmc Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49
    C Thollon
    Division Pathologies Cardiaques et Vasculaires, Institut de Recherches Servier, Suresnes, France
    Br J Pharmacol 112:37-42. 1994
    ..Intracellular recordings of action potentials (APs) were performed with conventional glass microelectrodes. 2...
  12. ncbi Nerve growth factor, sphingomyelins, and sensitization in sensory neurons
    Grant D Nicol
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Sheng Li Xue Bao 60:603-4. 2008
    ..NGF or 1 mmol/L N-acetyl sphingosine (C2-ceramide) produced a 3-4 fold increase in the number of action potentials (APs) evoked by a ramp of depolarizing current in a time-dependent manner...
  13. ncbi Human 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase: biochemistry, molecular biology and genetic deficiency
    K V Venkatachalam
    Department of Biochemistry, College of Medical Sciences, Health Professions Division, Nova Southeastern University, 3200 South University Dr, Ft Lauderdale, FL 33328 2018, USA
    IUBMB Life 55:1-11. 2003
    ..First inorganic sulfate combines with ATP to form adenosine 5'-phosphosulfate (APS) and pyrophosphate catalyzed by ATP sulfurylase domain and in the second step, APS combines with another molecule ..
  14. ncbi Crystal structure of ATP sulfurylase from Penicillium chrysogenum: insights into the allosteric regulation of sulfate assimilation
    I J MacRae
    Section of Molecular and Cellular Biology and Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA
    Biochemistry 40:6795-804. 2001
    ..7 kDa subunits (573 residues). The C-terminal allosteric domain of each subunit is homologous to APS kinase...
  15. doi Complement activation in patients with primary antiphospholipid syndrome
    K Oku
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Ann Rheum Dis 68:1030-5. 2009
    To investigate the significance of complement activation in patients with primary antiphospholipid syndrome (APS).
  16. ncbi Indoor air pollution by alkylphenols in Tokyo
    I Saito
    Department of Environmental Health and Toxicology, Division of Environment Health, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan
    Indoor Air 14:325-32. 2004
    The purposes of this study were to develop an analytical method for airborne alkylphenols (APs) using the gas chromatography/mass spectrometry (GC/MS)-SIM method and to investigate airborne C4-C9 APs pollution in houses, offices, and ..
  17. ncbi Cross-reactivity between anti-cardiolipin, anti-high-density lipoprotein and anti-apolipoprotein A-I IgG antibodies in patients with systemic lupus erythematosus and primary antiphospholipid syndrome
    J Delgado Alves
    Centre for Rheumatology, Department of Medicine, University College London, London, UK
    Rheumatology (Oxford) 42:893-9. 2003
    ..important complication of patients with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). One suggested mechanism may be the action of autoantibodies directed against plasma lipoproteins...
  18. ncbi Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction
    Corrado Betterle
    Chair of Clinical Immunology and Allergy, Department of Medical and Surgical Sciences, University of Padova, I 35128, Padova, Italy
    Endocr Rev 23:327-64. 2002
    ..Furthermore, the autoimmune polyglandular syndromes (APS) associated with AD (revised classification, animal models, genetics, natural history) have been discussed...
  19. doi Autoantibodies against type I interferons as an additional diagnostic criterion for autoimmune polyendocrine syndrome type I
    Antonella Meloni
    Pediatric Clinic II, Ospedale Microcitemico and Dipartimento di Sciencze Biomediche e Biotechno logiche, University of Cagliari, Cagliari, Sardinia, Italy
    J Clin Endocrinol Metab 93:4389-97. 2008
    In autoimmune polyendocrinopathy syndrome type I (APS-I), mutations in the autoimmune regulator gene (AIRE) impair thymic self-tolerance induction in developing T cells...
  20. ncbi Susceptibility alleles and haplotypes of human leukocyte antigen DRB1, DQA1, and DQB1 in autoimmune polyglandular syndrome type III in Japanese population
    Kozo Hashimoto
    Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Nankoku, Japan
    Horm Res 64:253-60. 2005
    ..However, little has been reported on the susceptibility HLA class II haplotypes in Japanese patients with autoimmune polyglandular syndrome type II and type III (APS III).
  21. ncbi Manipulation of thiol contents in plants
    R Höfgen
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Golm, Federal Republic of Germany
    Amino Acids 20:291-9. 2001
    ..relatively inert sulfate molecule is activated through binding to ATP forming adenosine-5'-phosphosulfate (APS). This enzymatic step is controlled through the enzyme ATP-sulfurylase (ATP-S)...
  22. ncbi Non-radioactive adenosine 5'-phosphosulfate sulfotransferase assay by coupling with sulfite reductase and O-acetylserine(thiol)lyase
    T Ara
    Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University, Japan
    Biosci Biotechnol Biochem 61:621-4. 1997
    Adenosine 5'-phosphosulfate (APS) sulfotransferase is thought to be an enzyme that transfers the sulfo-group of APS to a carrier compound with a thiol group in the assimilatory sulfate reduction pathway of higher plants...
  23. doi Photo degradation of methyl orange an azo dye by advanced Fenton process using zero valent metallic iron: influence of various reaction parameters and its degradation mechanism
    L Gomathi Devi
    Department of Post Graduate Studies in Chemistry, Central College City Campus, Bangalore University, Bangalore, India
    J Hazard Mater 164:459-67. 2009
    ..of various reaction parameters like effect of iron dosage, concentration of H(2)O(2)/ammonium per sulfate (APS), initial dye concentration, effect of pH and the influence of radical scavenger are studied and optimum conditions ..
  24. doi Autoantibodies against phosphatidylserine, prothrombin and phosphatidylserine-prothrombin complex: identical or distinct diagnostic tools for antiphospholipid syndrome?
    Troy D Jaskowski
    Associated Regional and University Pathologists ARUP Institute for Clinical and Experimental Pathology, University of Utah School of Medicine, Salt Lake City, UT, United States
    Clin Chim Acta 410:19-24. 2009
    To clarify the association and diagnostic utility of measuring antiphosphatidyl serine (aPS), antiprothrombin (aPT) and the antiphosphatidyl serine/prothrombin complex (aPS/PT) antibodies in patients with antiphospholipid syndrome (APS) ..
  25. ncbi [Severe neurological and obstetrical complications in a patient with antiphospholipid syndrome]
    Danuta Bobrowska-Snarska
    Klinika Reumatologii Pomorskiej AM w Szczecinie
    Pol Arch Med Wewn 115:457-62. 2006
    Antiphospholipd syndrome (APS) is a disease characterised by venous and arterial thrombosis or recurrent foetal loss, which are associated with antiphospholipid antibodies or/and lupus anticoagulant...
  26. pmc Homology modeling of dissimilatory APS reductases (AprBA) of sulfur-oxidizing and sulfate-reducing prokaryotes
    Birte Meyer
    Max Planck Institute for Marine Microbiology, Bremen, Germany
    PLoS ONE 3:e1514. 2008
    The dissimilatory adenosine-5'-phosphosulfate (APS) reductase (cofactors flavin adenine dinucleotide, FAD, and two [4Fe-4S] centers) catalyzes the transformation of APS to sulfite and AMP in sulfate-reducing prokaryotes (SRP); in sulfur-..
  27. pmc Calcium dynamics associated with action potentials in single nerve terminals of pyramidal cells in layer 2/3 of the young rat neocortex
    H J Koester
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Jahnstrasse 29, D 69120 Heidelberg, Germany
    J Physiol 529:625-46. 2000
    ..Single APs and trains of APs reliably evoked Ca2+ transients in en passant boutons located on axon collaterals in cortical ..
  28. ncbi Specificity and sensitivity of anti-beta2-glycoprotein I as compared with anticardiolipin antibody and lupus anticoagulant in Thai systemic lupus erythematosus patients with clinical features of antiphospholipid syndrome
    Virunya Parkpian
    Division of Allergy, Immunology and Rheumatology, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
    Clin Rheumatol 26:1663-70. 2007
    ..I (anti-beta(2)-GPI) have been reported to have stronger association with clinical antiphospholipid syndrome (APS) than anticardiolipin antibodies (aCL) and lupus anticoagulant (LAC)...
  29. ncbi Radiofrequency catheter ablation of right atriofascicular (Mahaim) accessory pathways guided by accessory pathway activation potentials
    J H McClelland
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190
    Circulation 89:2655-66. 1994
    BACKGROUND: Accessory pathways (APs) exhibiting "Mahaim fiber" physiology (antegrade conduction only, long conduction time, and decremental properties) often connect the lateral right atrium to the right bundle branch (right ..
  30. ncbi [Ocular manifestations in patients with systemic lupus erythematosus and antiphospholipid syndrome]
    Lidia Ostanek
    Klinika Reumatologii, Pomorska Akademia Medyczna, Szczecin
    Pol Arch Med Wewn 117:18-23. 2007
    ..It could be the reason for many organs and tissues impairment. Changes in eyes that occurr in SLE are not frequent, but can lead to severe impairment of sight including blindness...
  31. ncbi Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains
    Eric B Lansdon
    Department of Chemistry and Section of Molecular and Cellular Biology, University of California, One Shields Avenue, Davis, California 95616, USA
    Biochemistry 43:4356-65. 2004
    ..with each 71 kDa subunit containing an adenosine triphosphate (ATP) sulfurylase and an adenosine 5'-phosphosulfate (APS) kinase domain, catalyzes the overall formation of PAPS from ATP and inorganic sulfate...
  32. ncbi The use of portable computer for information acquirement during anesthesiologist's ward round in acute pain service
    Yung Lung Lee
    Department of Anesthesiology, Changhua Christian Hospital, Taiwan, ROC
    Acta Anaesthesiol Taiwan 45:79-87. 2007
    ..This study was to evaluate the use of PDA for acute pain assessment and compare the PDA-based method with that of the current paper-transcription method in work efficiency...
  33. pmc Identification of a second lipopolysaccharide in Porphyromonas gingivalis W50
    Minnie Rangarajan
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London Queen Mary s School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, United Kingdom
    J Bacteriol 190:2920-32. 2008
    We previously described a cell surface anionic polysaccharide (APS) in Porphyromonas gingivalis that is required for cell integrity and serum resistance...
  34. doi Laboratory testing for the antiphospholipid syndrome: making sense of antiphospholipid antibody assays
    Emmanuel J Favaloro
    Department of Haematology, Institute of Clinical Pathology and Medical Research ICPMR, Westmead Hospital, NSW, Australia
    Clin Chem Lab Med 49:447-61. 2011
    The antiphospholipid syndrome (APS) is an autoimmune condition characterised by a wide range of clinical features (primarily thrombosis and/or obstetric related), associated with the presence of antiphospholipid antibodies (aPL) as ..
  35. pmc The HELLP syndrome in the antiphospholipid syndrome: retrospective study of 16 cases in 15 women
    D Le Thi Thuong
    Departments of Internal Medicine, Groupe Hospitalier Pitie Salpetriere, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13, France
    Ann Rheum Dis 64:273-8. 2005
    To study the characteristics of the haemolysis, elevated liver enzymes, low platelets (HELLP) syndrome in the antiphospholipid syndrome (APS) and its influence on the subsequent pregnancies.
  36. ncbi A peptide that shares similarity with bacterial antigens reverses thrombogenic properties of antiphospholipid antibodies in vivo
    Silvia S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Dr SW, Rm 331 BSMB, Atlanta, GA 30310 1495, USA
    J Autoimmun 22:217-25. 2004
    ..Peptide A is also found in region I/II of beta2GPI. A scrambled form of peptide A (named scA, GTKGCPNVRLT) was used as a control...
  37. doi Novel sequence variation of AIRE and detection of interferon-omega antibodies in early infancy
    Beáta Tóth
    Department of Infectious and Pediatric Immunology, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
    Clin Endocrinol (Oxf) 72:641-7. 2010
    Autoimmune polyendocrine syndrome type I (APS I) is a rare primary immunodeficiency disorder characterized by chronic mucocutaneous candidiasis, multi-organ autoimmunity and ectodermal dysplasia...
  38. doi Polysaccharides from Astragalus membranaceus promote phagocytosis and superoxide anion (O2-) production by coelomocytes from sea cucumber Apostichopus japonicus in vitro
    Yongxin Sun
    Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian, 116024, People s Republic of China
    Comp Biochem Physiol C Toxicol Pharmacol 147:293-8. 2008
    The potential immunostimulatory effects of Astralagus membranaceus polysaccharides (APS) on sea cucumber, Apostichopus japonicus (Selenka), were investigated in vitro...
  39. ncbi Increased platelet deposition on extracellular matrix under flow conditions in patients with antiphospholipid syndrome who experience thrombotic events
    Yair Levy
    Meir Medical Center, Kfar Saba, Israel
    Arthritis Rheum 52:4011-7. 2005
    To assess platelet function under defined flow conditions in patients with antiphospholipid syndrome (APS) and to correlate the results with thrombotic complications and the presence of subsets of antiphospholipid antibodies (aPL), lupus ..
  40. ncbi Phase relation changes between the firings of alpha and gamma-motoneurons and muscle spindle afferents in the sacral micturition centre during continence functions in brain-dead human and patients with spinal cord injury
    G Schalow
    Electromyogr Clin Neurophysiol 50:3-27. 2010
    1. Single-nerve fibre action potentials (APs) were recorded with 2 pairs of wire electrodes from lower sacral nerve roots during surgery in patients with spinal cord injury and in a brain-dead human...
  41. ncbi Sulfate-activating enzymes of Penicillium chrysogenum. The ATP sulfurylase.adenosine 5'-phosphosulfate complex does not serve as a substrate for adenosine 5'-phosphosulfate kinase
    F Renosto
    Department of Biochemistry and Biophysics, University of California, Davis 95616
    J Biol Chem 264:9433-7. 1989
    At a noninhibitory steady state concentration of adenosine 5'-phosphosulfate (APS), increasing the concentration of Penicillium chrysogenum ATP sulfurylase drives the rate of the APS kinase-catalyzed reaction toward zero...
  42. pmc Evoked potential studies in the antiphospholipid syndrome: differential diagnosis from multiple sclerosis
    D Paran
    Department of Rheumatology, Tel Aviv Sourasky Medical Centre, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Ann Rheum Dis 65:525-8. 2006
    The CNS manifestations of the antiphospholipid syndrome (APS) can mimic multiple sclerosis both clinically and radiologically.
  43. ncbi The antiphospholipid syndrome in pregnant rabbits and their offspring. Neuropathological aspects
    Przemysław Nowacki
    Department of Neurology, Pomeranian Medical University, Szczecin, Poland
    Folia Neuropathol 43:15-22. 2005
    Although the obstetric consequences of antiphospholipid syndrome (APS) in pregnant rabbits have been described, there are no data on the serological and neuropathological aspects of the syndrome in their offspring...
  44. ncbi ATP sulfurylase from filamentous fungi: which sulfonucleotide is the true allosteric effector?
    I MacRae
    Section of Molecular and Cellular Biology, University of California, Davis 95616, USA
    Arch Biochem Biophys 337:17-26. 1997
    ..inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS), the product of adenosine 5'-phosphosulfate (APS) kinase, the second enzyme in the sulfate activation sequence...
  45. ncbi [Effects of Astragalus polysaccharides and Cordyceps sinensis mycelium mixture on the transforming growth factor-beta1 expression in chronic rejection of artery transplantation: experiment with rats]
    Song Zhao
    Department of General Surgery, First Affiliated Hospital, Harbin Medical University, Heilongjiang Province, Harbin 150001, China
    Zhonghua Yi Xue Za Zhi 87:851-4. 2007
    To explore the effect of Astragalus polysaccharides (APS) and Cordyceps sinensis (CP) mycelium mixture on the chronic rejection of artery transplantation.
  46. ncbi Antiphospholipid syndrome nephropathy in patients with systemic lupus erythematosus and antiphospholipid antibodies: prevalence, clinical associations, and long-term outcome
    Maria G Tektonidou
    Department of Pathophysiology, School of Medicine, National University of Athens, Athens, Greece
    Arthritis Rheum 50:2569-79. 2004
    To evaluate the prevalence, clinical associations, and outcome of antiphospholipid syndrome (APS) nephropathy in patients with systemic lupus erythematosus (SLE) and antiphospholipid antibodies (aPL) and in SLE patients without aPL.
  47. ncbi Circulating levels of tissue factor and proinflammatory cytokines in patients with primary antiphospholipid syndrome or leprosy related antiphospholipid antibodies
    R R Forastiero
    Favaloro University, Favaloro Foundation, Buenos Aires, Argentina
    Lupus 14:129-36. 2005
    The antiphospholipid syndrome (APS) is characterized by the presence of antiphospholipid antibodies (aPL) in patients with thromboembolic complications...
  48. ncbi Ligand-induced structural changes in adenosine 5'-phosphosulfate kinase from Penicillium chrysogenum
    Eric B Lansdon
    Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA
    Biochemistry 41:13672-80. 2002
    Adenosine 5'-phosphosulfate (APS) kinase catalyzes the second reaction in the two-step, ATP-dependent conversion of inorganic sulfate to 3'-phosphoadenosine 5'-phosphosulfate (PAPS)...
  49. doi An acute pain service improves postoperative pain management for children undergoing selective dorsal rhizotomy
    Chantal Frigon
    Department of Anesthesiology, McGill University Health Center, Montreal Children s Hospital, Montreal, QC, Canada
    Paediatr Anaesth 19:1213-9. 2009
    ..The aim of the study was to evaluate the impact of having an organized acute pain service (APS) on postoperative pain management of these children.
  50. ncbi Protective effects of emodin and astragalus polysaccharides on chronic hepatic injury in rats
    Shuang Suo Dang
    Department of Infectious Diseases, The Second Hospital of Xi an Jiaotong University, Xi an, Shaanxi, China
    Chin Med J (Engl) 121:1010-4. 2008
    Chinese medicine plays an important role in hepatoprotective treatment. This study was conducted to investigate the protective effects of emodin and astragalus polysaccharides (APS) in a rat model of chronic hepatic injury.
  51. ncbi The isolation and characterization of cDNA encoding the mouse bifunctional ATP sulfurylase-adenosine 5'-phosphosulfate kinase
    H Li
    Department of Pediatrics, University of Chicago, Illinois 60637, USA
    J Biol Chem 270:29453-9. 1995
    ..action of two enzyme activities: ATP sulfurylase, which catalyzes the formation of adenosine 5'-phosphosulfate (APS) from ATP and free sulfate, and APS kinase, which subsequently phosphorylates APS to produce adenosine 3'-phosphate ..
  52. ncbi A cost-utility and cost-effectiveness analysis of an acute pain service
    Michaela Stadler
    Department of Anesthesiology, University Hospital Center, Charleroi, Belgium
    J Clin Anesth 16:159-67. 2004
    To analyze, from a societal perspective, the cost-effectiveness and cost-utility of acute pain management after inception of a nurse-based Acute Pain Service (APS) in a general hospital.
  53. doi A novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway
    W Cao
    Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, 169 West Changle Road, Xi an, Shaanxi 710032, China
    Phytomedicine 17:598-605. 2010
    A novel polysaccharide isolated from Angelica sinensis, named APS-1d showed cytotoxic activity towards several cancer cell lines in vitro. However, the precise antitumor mechanisms of this compound are unknown...
  54. ncbi Astragalus polysaccharides: an effective treatment for diabetes prevention in NOD mice
    W Chen
    Department of Geriatrics, Huashan Hospital, Fudan University of Shangai, China
    Exp Clin Endocrinol Diabetes 116:468-74. 2008
    ..Astragalus polysaccharides (APS) are bioactive components extracted from one of the traditional Chinese herbs, used to enhance the function of ..
  55. ncbi Arterialisation of the portal vein as a model for the induction of hepatic fibrosis: description of microsurgical models in the rat
    Volker Muller
    Department of Surgery, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Transpl Int 17:822-33. 2005
    ..inserted in the right renal artery (PVA-B), the second with unrestricted flow using an aortic-portal segment (PVA-APS). The third technique was orthotopic liver transplantation with unrestricted portal arterialisation (OLTx-APS)...
  56. ncbi Factor XIII in primary antiphospholipid syndrome
    Paul R J Ames
    Academic Department of Rheumatology, Leeds General Infirmary, Leeds, UK
    J Rheumatol 32:1058-62. 2005
    To evaluate the clinical significance of factor XIII (FXIII) in primary antiphospholipid syndrome (APS).
  57. ncbi Clusters of disease manifestations in patients with antiphospholipid syndrome demonstrated by factor analysis
    I Krause
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Israel
    Lupus 16:176-80. 2007
    The antiphospholipid syndrome (APS) is now recognized as a multi-system disease, the clinical expression of which may include various target-organs involvements...
  58. ncbi Novel autoantibodies against the activated coagulation factor IX (FIXa) in the antiphospholipid syndrome that interpose the FIXa regulation by antithrombin
    Yao Hsu Yang
    Division of Rheumatology, Department of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 182:1674-80. 2009
    We previously reported that some human antiphospholipid Abs (aPL) in patients with the antiphospholipid syndrome (APS) bind to the homologous enzymatic domains of thrombin and the activated coagulation factor X (FXa)...
  59. pmc Modulation of Ca(2+)-activated K+ currents and Ca(2+)-dependent action potentials by exocytosis in goldfish bipolar cell terminals
    Mary J Palmer
    Neuroscience Group, Institute for Science and Technology in Medicine, Keele University, Keele ST5 5BG, UK
    J Physiol 572:747-62. 2006
    ..They do not fire Na(+)-dependent action potentials (APs) but the Mb1 class of goldfish bipolar cell exhibits Ca(2+)-dependent APs and regenerative potentials that ..
  60. ncbi Use of a new silica clotting time for diagnosing lupus anticoagulant in patients who meet the clinical criteria for antiphospholipid syndrome
    Panagiotis Grypiotis
    Rheumatology Unit, University of Padova, Padova, Italy
    J Clin Lab Anal 20:15-8. 2006
    ..a new commercial SCT for identifying LA in patients who meet the clinical criteria for antiphospholipid syndrome (APS), and its association with thrombotic events were evaluated here...
  61. ncbi Oligonucleotide model with non-identical complementary strands for chromatographic studies of structure-dependent photosusceptibility
    V N Potaman
    Department of Biology, George Mason University, Fairfax, VA 22030
    J Chromatogr A 690:65-70. 1995
    ..F6 and the ordinary antiparallel-stranded (aps) F5.F7 duplexes...
  62. doi [Autoimmune polyglandular syndromes]
    M P Hansen
    I Medizinische Klinik und Poliklinik, SP Endokrinologie, Universitätsmedizin Mainz der Johannes Gutenberg Universität
    Dtsch Med Wochenschr 138:319-26; quiz 327-8. 2013
    The autoimmune polyglandular syndrome (APS) is defined as the manifestation of at least two endocrine autoimmune diseases...
  63. ncbi [Corticosteroids in the treatment of secondary antiphospholipid syndrome]
    T M Reshetniak
    Klin Med (Mosk) 80:17-21. 2002
    ..in the levels of antiphospholipid antibodies (aPL) and clinical manifestations of antiphospholipid syndrome (APS) in response to corticosteroids in secondary APS in patients with systemic lupus erythematosus (SLE) included 219 ..
  64. ncbi Flutamide counteracts the antiproliferative effects of antiprogestins in the primate endometrium
    Ov D Slayden
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    J Clin Endocrinol Metab 88:946-9. 2003
    In addition to blocking progesterone (P) action, antiprogestins (APs) also inhibit estrogen-stimulated endometrial cell proliferation in nonhuman primates and women...
  65. ncbi Cellular distribution of anionic antimicrobial peptide in normal lung and during acute pulmonary inflammation
    A J Fales-Williams
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames 50011 1250, USA
    Vet Pathol 39:706-11. 2002
    Anionic peptides (APs) are small antimicrobial peptides present in human and ovine lung...
  66. ncbi Double heterozygosity polymorphisms for platelet glycoproteins Ia/IIa and IIb/IIIa increases arterial thrombosis and arteriosclerosis in patients with the antiphospholipid syndrome or with systemic lupus erythematosus
    S Jimenez
    Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Barcelona, Catalonia, Spain
    Ann Rheum Dis 67:835-40. 2008
    ..GP) Ib-alpha, Ia/IIa and IIb/IIIa and their correlation with the development of arterial thrombosis and preclinical arteriosclerosis in patients with antiphospholipid syndrome (APS) or with systemic lupus erythematosus (SLE).
  67. pmc Lipid droplets, perilipins and cytokeratins--unravelled liaisons in epithelium-derived cells
    Hans Heid
    Helmholtz Group for Cell Biology, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 8:e63061. 2013
    ..hydrophobic substances and are generally surrounded by a thin cortical layer of specific amphiphilic proteins (APs). These APs segregate the LDs from the mostly polar components of the cytoplasm...
  68. pmc Cell type-specific relationships between spiking and [Ca2+]i in neurons of the Xenopus tadpole olfactory bulb
    Bei Jung Lin
    Institute of Physiology, University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    J Physiol 582:163-75. 2007
    Multi-neuronal recordings with Ca2+ indicator dyes usually relate [Ca2+]i to action potentials (APs) assuming a stereotypical dependency between the two...
  69. doi Prevalence of antibodies to prothrombin in solid phase (aPT) and to phosphatidylserine-prothrombin complex (aPS/PT) in patients with and without lupus anticoagulant
    Maria Laura Bertolaccini
    Lupus Research Unit, The Rayne Institute, Division of Women s Health, King s College London, 4th Floor Lambeth Wing, St Thomas Hospital, London SE1 7EH, UK
    Thromb Haemost 109:207-13. 2013
    Antibodies to prothrombin in solid phase (aPT) and those to phosphatidiyserine-prothrombin complex (aPS/PT) have been suggested to strongly correlate with the presence of lupus anticoagulant (LA)...
  70. ncbi In vivo role of adenosine-5'-phosphosulfate reductase in the purple sulfur bacterium Allochromatium vinosum
    O Sanchez
    Department of Genetics and Microbiology, Autonomous University of Barcelona, 08193 Bellaterra, Spain
    Arch Microbiol 176:301-5. 2001
    Adenosine-5'-phosphosulfate (APS) reductase participates in the oxidation of sulfite to APS in Allochromatium vinosum. Oxidation of sulfite via the APS pathway yields ATP through substrate-level phosphorylation...
  71. ncbi Primary anti-phospholipid antibody syndrome (APS): current concepts
    Omar M Durrani
    Academic Unit of Ophthalmology, University of Birmingham, Birmingham, United Kingdom
    Surv Ophthalmol 47:215-38. 2002
    Primary anti-phospholipid syndrome (APS) is a thrombophilic state characterized by recurrent arterial and venous thrombosis, recurrent pregnancy loss, and the presence of circulating anti-phospholipid antibodies that may be responsible ..
  72. doi Prevalence of the antiphospholipid syndrome and its effect on survival in 679 Chinese patients with systemic lupus erythematosus: a cohort study
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, Hong Kong, China
    Medicine (Baltimore) 92:217-22. 2013
    In this work we evaluate the prevalence of the antiphospholipid syndrome (APS) and its impact on survival in Chinese patients with systemic lupus erythematosus (SLE)...
  73. ncbi Dynamic remodeling of K+ and Ca2+ currents in cells that survived in the epicardial border zone of canine healed infarcted heart
    Wen Dun
    Department of Pharmacology, Center of Molecular Therapeutics, Columbia University, New York, New York 10032, USA
    Am J Physiol Heart Circ Physiol 287:H1046-54. 2004
    Action potentials (APs) of the epicardial border zone (EBZ) cells from the day 5 infarcted heart continue to be altered by day 14 postocclusion, namely, they shortened...
  74. ncbi Longitudinal study of antinuclear and anticardiolipin antibodies in pregnant women with systemic lupus erythematosus and antiphospholipid syndrome
    Mario Salazar-Paramo
    Clinical Epidemiology Research Unit, Hospital de Especialidades, Centro Medico Nacional de Occidente, Instituto Mexicano del Seguro Social and Department of Physiology, CUCS, Universidad de Guadalajara, Guadalajara, Mexico
    Rheumatol Int 22:142-7. 2002
    ..throughout pregnancy in a group of patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) patients during their therapy for the prevention of fetal loss and to examine their relationship with pregnancy ..
  75. doi Astragalus polysaccharide reduces inflammatory response by decreasing permeability of LPS-infected Caco2 cells
    Xiaofei Wang
    College of Animal Science and Technology, Northwest A and F University, Yangling, Shaanxi, 712100, China
    Int J Biol Macromol 61:347-52. 2013
    As the major constituent of Radix Astragali, Astragalus polysaccharide (APS) is known for its anti-inflammation and immunomodulatory functions...
  76. doi Moderate/severe erectile dysfunction in patients with antiphospholipid syndrome
    A Lopes Gallinaro
    Rheumatology Division, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Brazil
    Lupus 21:319-23. 2012
    To evaluate sexual function of antiphospholipid syndrome (APS) patients using the Brazilian version of the validated International Index of Erectile Function (IIEF).
  77. doi Thrombotic microangiopathy due to multiple autoantibodies related to antiphospholipid syndrome
    Shunsuke Noda
    Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo 157 8535, Japan
    Pediatr Nephrol 27:681-5. 2012
    Antiphospholipid syndrome (APS) is a rare disorder in children. More than half of childhood APS occurs as secondary APS complicated by systemic lupus erythematosus (SLE) and other autoimmune diseases.
  78. doi Evaluation of anticoagulation in patients with antiphospholipid syndrome
    Kathleen E Horner
    Department of Pharmaceutical Care, University of Iowa Hospitals and Clinics UIHC, Iowa City, IA 52242, USA
    Am J Health Syst Pharm 65:964-7. 2008
    The quality of anticoagulation therapy in patients with antiphospholipid syndrome (APS) was evaluated.
  79. doi Crystal structure of Saccharomyces cerevisiae 3'-phosphoadenosine-5'-phosphosulfate reductase complexed with adenosine 3',5'-bisphosphate
    Zhihao Yu
    Departments of Chemistry and Molecular and Cellular Biology, University of California, Davis, One Shields Avenue, Davis, California 95616
    Biochemistry 47:12777-86. 2008
    Most assimilatory bacteria, fungi, and plants species reduce sulfate (in the activated form of APS or PAPS) to produce reduced sulfur. In yeast, PAPS reductase reduces PAPS to sulfite and PAP...
  80. ncbi Antiphospholipid syndrome (APS) nephropathy in catastrophic, primary, and systemic lupus erythematosus-related APS
    Maria G Tektonidou
    Department of Pathophysiology, School of Medicine, National University of Athens, and Rheumatology Department, Euroclinic Hospital, Athens, Greece
    J Rheumatol 35:1983-8. 2008
    Renal involvement in antiphospholipid syndrome (APS) has been poorly recognized...
  81. ncbi High levels of NK cells in the peripheral blood of patients affected with anti-phospholipid syndrome and recurrent spontaneous abortion: a potential new hypothesis
    C Perricone
    Department of Rheumatology, University of Rome Tor Vergata, Rome, Italy
    Rheumatology (Oxford) 46:1574-8. 2007
    No data regarding phenotypic assets of circulating lymphocytes in anti-phospholipid syndrome (APS) are reported in the literature...
  82. ncbi Intermediate channeling between ATP sulfurylase and adenosine 5'-phosphosulfate kinase from rat chondrosarcoma
    S Lyle
    Department of Pediatrics, University of Chicago, Illinois 60637
    Biochemistry 33:6822-7. 1994
    ..ATP sulfurylase catalyzes the formation of APS (adenosine 5'-phosphosulfate) from ATP and free sulfate, and APS is then phosphorylated by APS kinase to produce ..
  83. ncbi Antiphospholipid antibodies and migraine: a retrospective study of 428 patients with inflammatory connective tissue diseases
    R Tanasescu
    Carol Davila University of Medicine and Pharmacy, Department of Neurology, Colentina Hospital, Bucharest, Romania
    Rom J Intern Med 45:355-63. 2007
    The antiphospholipid syndrome (APS) is defined by the presence of antiphospholipid antibodies (aPL), associated with thrombosis or recurrent spontaneous abortions...
  84. ncbi Deletion and site-directed mutagenesis of the ATP-binding motif (P-loop) in the bifunctional murine ATP-sulfurylase/adenosine 5'-phosphosulfate kinase enzyme
    A T Deyrup
    Department of Pediatrics, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 273:9450-6. 1998
    ..The recently cloned murine ATP-sulfurylase/adenosine 5'-phosphosulfate (APS) kinase contains a P-loop (residues 59-66) in the APS kinase portion of the bifunctional protein...
  85. ncbi [Components of hair bleaches as triggers of bronchial hypersensitivity--studies using a model for occupationally-induced lung damage]
    T Mensing
    ,
    Pneumologie 49:418-27. 1995
    Ammonium persulfate (APS) is used as an oxidant in many industrial branches and is contained in bleaching substances used in hair cosmetic industry. In addition to skin diseases, respiratory disorders have been frequently reported...
  86. doi Renal involvement in the antiphospholipid syndrome (APS)-APS nephropathy
    Maria G Tektonidou
    Department of Pathophysiology, School of Medicine, National University of Athens, Athens, Greece
    Clin Rev Allergy Immunol 36:131-40. 2009
    Although the kidney represents a major target organ in antiphospholipid syndrome (APS), renal involvement in APS was poorly recognized until recently...
  87. ncbi Factor XIII-A subunit Val34Leu polymorphism is associated with the risk of thrombosis in patients with antiphospholipid antibodies and high fibrinogen levels
    Gloria de la Red
    Department of Hemotherapy and Hemostasis, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Thromb Haemost 101:312-6. 2009
    ..We included 172 consecutive patients with aPL: 88 with primary antiphospholipid syndrome (APS), 38 with APS associated with systemic lupus erythematosus (APS-SLE), 32 with SLE and aPL but without APS (SLE-aPL),..
  88. ncbi Towards multimodal HPLC separations on humic acid-bonded aminopropyl silica: RPLC and LEC behavior
    Orhan Gezici
    Nigde University, Faculty of Science and Arts, Chemistry Department, 51100, Nigde, Turkey
    Talanta 85:2405-10. 2011
    ..Humic-acid bonded aminopropyl silica (EC-HA-APS) was turned into ligand exchanger forms by loading aqueous solutions of Cu(2+), and Co(2+) to the column (4...
  89. doi The avidity of anti-beta2-glycoprotein I antibodies in patients with or without antiphospholipid syndrome: a collaborative study in the frame of the European forum on antiphospholipid antibodies
    S Cucnik
    University Medical Centre, Department of Rheumatology, Ljubljana, Slovenia
    Lupus 20:1166-71. 2011
    ..I antibodies (anti-β2-GPI) on a larger group of patients with primary or secondary antiphospholipid syndrome (APS) and anti-β2-GPI positive patients without APS in the frame of the European Forum on antiphospholipid antibodies (..
  90. pmc Astragalus polysaccharides attenuate postburn sepsis via inhibiting negative immunoregulation of CD4+ CD25(high) T cells
    Qing Yang Liu
    Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing, People s Republic of China
    PLoS ONE 6:e19811. 2011
    Astragalus polysaccharides (APS) isolated from one of the Chinese herbs, Astragalus mongholicus, are known to have a variety of immunomodulatory activities...
  91. doi Comparison of the SidePak personal monitor with the Aerosol Particle Sizer (APS)
    Araceli Sánchez Jiménez
    Institute of Occupational Medicine, Edinburgh, United Kingdom
    J Environ Monit 13:1841-6. 2011
    The aim of this study was to compare the performance of the TSI Aerodynamic Particle Sizer (APS) and the TSI portable photometer SidePak to measure airborne oil mist particulate matter (PM) with aerodynamic diameters below 10 μm, 2...
  92. doi Autoimmune polyglandular syndrome type 2 shows the same HLA class II pattern as type 1 diabetes
    C Weinstock
    German Red Cross Blood Service West, Hagen, Germany
    Tissue Antigens 77:317-24. 2011
    Autoimmune polyglandular syndrome (APS) type 2 is defined by the manifestation of at least two autoimmune endocrine diseases. Only few data exist on genetic associations of APS type 2...
  93. ncbi [Autoimmune polyendocrine syndrome type 2 associated with autoimmune hypophysitis and coeliac disease]
    K Hrubisková
    V Interná klinika Lekárskej fakulty UK a FNsP Bratislava, Slovenska republika
    Vnitr Lek 56:1169-76. 2010
    Autoimmune polyendocrine syndromes (APS) are organ-specific autoimmune disorders affecting multiple endocrine glands; these are gradually destroyed by action of autoantibodies...
  94. doi Abbey Pain Scale: development and validation of the Japanese version
    Yukari Takai
    Department of Gerontological Nursing, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Geriatr Gerontol Int 10:145-53. 2010
    The purpose of this study was to develop and validate the Japanese version of the Abbey Pain Scale (APS-J), to assess pain of older adults who live in nursing homes in Japan.
  95. doi Autoimmune polyglandular syndrome type 1 in Russian patients: clinical variants and autoimmune regulator mutations
    Elizaveta M Orlova
    Endocrinology Research Centre, Institute of Paediatric Endocrinology, Moscow, Russia elizaveta orlova mail ru
    Horm Res Paediatr 73:449-57. 2010
    Autoimmune polyglandular syndrome type 1 (APS-1) (OMIM 240300) is a rare autosomal recessive disorder associated with three major manifestations: chronic mucocutaneous candidiasis, hypoparathyroidism, and adrenal insufficiency...
  96. doi Oxidation of the diphosphoinositol polyphosphate phosphohydrolase-like Nudix hydrolase Aps from Drosophila melanogaster induces thermolability--A possible regulatory switch?
    Lucinda Winward
    Division of Cell Signalling, University of Dundee, Dow Street, Dundee DD1 4HN, United Kingdom
    Int J Biochem Cell Biol 42:1174-81. 2010
    ..In order to evaluate its function, Aps was cloned and characterized...
  97. pmc Evidence that actomyosin cross bridges contribute to "passive" tension in detrusor smooth muscle
    Paul H Ratz
    Departments of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0614, USA
    Am J Physiol Renal Physiol 298:F1424-35. 2010
    ..smooth muscle (DSM) at short muscle lengths generates a stiffness component we termed adjustable passive stiffness (APS) that is retained in tissues incubated in a Ca(2+)-free solution, shifts the DSM length-passive tension curve up ..
  98. ncbi Comparison of the 1999 Sapporo and 2006 revised criteria for the classification of the antiphospholipid syndrome
    C Solano
    Department of Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Clin Exp Rheumatol 27:914-9. 2009
    The 2006 revised criteria for antiphospholipid syndrome (APS) provide a new classification challenge, and studies validating the updated criteria against the older ones are still scanty...
  99. ncbi [Classification and clinical analysis of 165 patients with antiphospholipid syndrome.]
    Na Xu
    Department of Rheumatology Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100032, China Email
    Zhonghua Nei Ke Za Zhi 48:904-7. 2009
    Based on 2006 revised classification criteria of definite antiphospholipid syndrome (APS) and definition of new APS subsets, we investigated clinical features of APS patients, correlation between thrombotic events and related antibodies ..
  100. doi Pregnancy outcome in different clinical phenotypes of antiphospholipid syndrome
    K Bramham
    Department of Maternal Medicine, Women s services directorate and Lupus Unit, Guy s and St Thomas NHS Foundation Trust, London, UK
    Lupus 19:58-64. 2010
    Women with antiphospholipid syndrome (APS) may have diverse pregnancy outcomes. The objective of this study was to evaluate pregnancy outcome in women with APS according to their clinical phenotype, i.e. thrombotic and obstetric APS...
  101. pmc Astragalus mongholicus polysaccharide inhibits lipopolysaccharide-induced production of TNF-alpha and interleukin-8
    Yuan Yuan
    Department of Pediatrics, Shengjing Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
    World J Gastroenterol 15:3676-80. 2009
    To explore the effect of Astragalus mongholicus polysaccharide (APS) on gene expression and mitogen-activated protein kinase (MAPK) transcriptional activity in intestinal epithelial cells (IEC).

Research Grants106 found, 100 shown here

  1. Reduction of Annexin A5 in Antiphospholipid Pregnancy Loss
    JACOB RAND; Fiscal Year: 2007
    Recurrent pregnancy losses are a hallmark of the antiphospholipid syndrome (APS), a complicated major hypercoagulable disorder without an established mechanism that is currently diagnosed with phenomenologic surrogate tests...
  2. Antimicrobial Peptides and Innate Immunity in Otitis Media
    LAUREN BAKALETZ; Fiscal Year: 2009
    ..Antimicrobial peptides (APs) are key components of the innate immune system, providing first-line inactivation of microbes on the vast ..
  3. Excitation-contraction Coupling in Normal and Dystrophic Mammalian Muscle
    Julio L Vergara; Fiscal Year: 2010
    ..We have found that Ca2+ release evoked by action potentials (APs) (or voltage-clamp pulses) in muscle fibers from two of such models, the adult mdx mouse and the phenotypic ..
  4. Predictors of Pregnancy Outcome in SLE and APS
    Jane Salmon; Fiscal Year: 2009
    Pregnancy complications in women with the antiphospholipid syndrome (APS) and/or SLE include recurrent miscarriage, preeclampsia, placental insufficiency, and intrauterine growth restriction (IUGR)...
  5. Predictors of Pregnancy Outcome in SLE and APS
    Jane E Salmon; Fiscal Year: 2010
    Pregnancy complications in women with the antiphospholipid syndrome (APS) and/or SLE include recurrent miscarriage, preeclampsia, placental insufficiency, and intrauterine growth restriction (IUGR)...
  6. ANTICARDIOLIPIN ANTIBODIES AND OXIDIZED PHOSPHOLIPIDS
    Joseph Witztum; Fiscal Year: 2004
    Patients with the antiphospholipid antibody syndrome (APS) have autoantibodies to certain phospholipids (aPL) such as cardiolipin and/or the lupus anticoagulant and clinically experience recurrent venous or arterial thrombosis, history ..
  7. ANTICARDIOLIPIN ANTIBODIES AND OXIDIZED PHOSPHOLIPIDS
    Joseph Witztum; Fiscal Year: 2000
    DESCRIPTION (Adapted from Investigator's Abstract): Patients with the antiphospholipid syndrome (APS) have autoantibodies to certain phospholipids such as cardiolipin and/or the lupus anticoagulant and clinically experience recurrent ..
  8. THERAPY WITH ANNEXINS FOR ANTIPHOSPHOLIPID SYNDROME
    MARIA BEGONA CAMPOS NACIFF; Fiscal Year: 2004
    DESCRIPTION: (Scanned from the applicant's description): APS is a disorder characterized by venous and arterial thrombosis, recurrent fetal loss, thrombocytopenia and by the presence of antiphospholipid antibodies...
  9. Predictors of Pregnancy Outcome in SLE and APS
    Jane Salmon; Fiscal Year: 2007
    ..Our studies in a murine model of antiphospholipid antibody syndrome (APS) indicate that in vivo complement activation is necessary for fetal loss caused by aPL antibodies...
  10. AUTOIMMUNE MECHANISMS OF THROMBOSIS
    Robert Roubey; Fiscal Year: 2004
    The Antiphospholipid Syndrome (APS) represents an interface between the immune system and blood coagulation...
  11. ANTICARDIOLIPIN ANTIBODIES IN ANTIPHOSPHOLIPID SYNDROME
    Pojen Chen; Fiscal Year: 2007
    ..are to identify and characterize pathogenic anticardiolipin antibodies (aCL) in the antiphospholipid syndrome (APS)...
  12. TREATMENT STRATEGIES FOR THE ANTI PHOSPHOLIPID SYNDROME
    JOHN DEDMAN; Fiscal Year: 2003
    Antiphospholipid Syndrome (APS), also known as Hughes Syndrome, is a multiorgan vascular disease associated with myocardial infarction, stroke thrombosis and recurrent fetal loss...
  13. Regulation of the anti-phospholipid response in SLE
    Anne Davidson; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Antiphospholipid syndrome (APS) is a devastating autoimmune condition that causes recurrent blood clots and has no effective treatment apart from ..
  14. Isolation of Autoantibodies to Apoptotic Cells
    Marko Radic; Fiscal Year: 2004
    ..evidence links the initiation and progression of Systemic Lupus Erythematosus (SLE) and Anti-Phospholipid Syndrome (APS) to aberrant immune responses to apoptotic cells...
  15. Mechanisms of aPL antibody-induced pregnancy loss
    Jane Salmon; Fiscal Year: 2007
    The antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy loss that occur in the presence of antiphospholipid (aPL) antibodies...
  16. Mechanism of aPL antibody-induced Pregnancy loss
    Jane E Salmon; Fiscal Year: 2010
    The antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy loss that occur in the presence of antiphospholipid (aPL) antibodies...
  17. Mechanism of aPL antibody-induced Pregnancy loss
    Jane Salmon; Fiscal Year: 2009
    The antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy loss that occur in the presence of antiphospholipid (aPL) antibodies...
  18. Reduction of Annexin A5 in Antipholipid Pregnancy Loss
    JACOB RAND; Fiscal Year: 2010
    Recurrent pregnancy losses are a hallmark of the antiphospholipid syndrome (APS), a complicated major hypercoagulable disorder without an established mechanism that is currently diagnosed with phenomenologic surrogate tests...
  19. Pathophysiology of anti-B2GPI Antibodies in APS
    ALISA WOLBERG; Fiscal Year: 2007
    ..The prevalence of venous thrombosis associated with the primary Antiphospholipid Syndrome (APS) may be as high as 0...
  20. Factors that Initiate Arrhythamias in Long QT Syndrome
    Guy Salama; Fiscal Year: 2006
    ..will be perfused, stained with voltage and Ca 2+ - sensitive dyes to simultaneously map action potentials (APs) and intracellular Ca 2v(Cai) transients from 256 sites at high spatial and temporal resolution...
  21. KALLIKREIN KININ SYSTEM IN INFLAMMATORY BOWEL DISEASE
    Robert Colman; Fiscal Year: 2001
    We have shown that bacterial products (proteoglycan-polysaccharide, PG- APS) found in the lower bowel produce chronic granulomatous inflammation similar to Crohn's disease (regional ileitis) in genetically susceptible rats as well as ..
  22. Innate Immunity in Experimental Arthritis of Kininogen
    Robert Colman; Fiscal Year: 2007
    ..Parenterally injected peptidoglycanpolysaccharide complexes (PG-APS) induce a systemic inflammatory response consisting of erosive polyarthritis, hepatic granulomas, and anemia...
  23. Antiphospholipid antibodies and lupus: new molecular targets for treatment
    Silvia S Pierangeli; Fiscal Year: 2010
    ..thrombosis and pregnancy loss in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). Thrombosis is an important cause of morbidity and mortality in APS and SLE patients with aPL Abs...
  24. Gender-Differences in Cardiac Repolarization/Arrhythmias
    Guy Salama; Fiscal Year: 2005
    ..Optical maps of APs and Cai transients q selective blockers for IKr, IKs and ICa will elucidate gender differences in the spatial ..
  25. Factors that Initiate Arrhythmias in lung QT Syndrome
    Guy Salama; Fiscal Year: 2004
    ..branches, will be perfused, stained with voltage and Ca2+ sensitive dyes to simultaneously map action potentials (APs) and intracellular Ca2+ (Ca1) transients from 256 sites at high spatial and temporal resolution...
  26. Antimicrobial Peptides and Innate Immunity in Otitis Media
    Lauren O Bakaletz; Fiscal Year: 2010
    ..Antimicrobial peptides (APs) are key components of the innate immune system, providing first-line inactivation of microbes on the vast ..
  27. Haemophilus ducreyi Resistance to Antimicrobial Peptides
    MARGARET BAUER; Fiscal Year: 2007
    ..A key component of the innate immune response to pathogens is production of bactericidal antimicrobial peptides (APs)...
  28. Antimicrobial Peptides and Innate Immunity in Otitis Media
    LAUREN BAKALETZ; Fiscal Year: 2009
    ..Antimicrobial peptides (APs) are key components of the innate immune system, providing first-line inactivation of microbes on the vast ..
  29. MOLECULAR STUDIES OF SELECTIVE PROTEIN TRANSPORT
    Gregory Payne; Fiscal Year: 1993
    ..further define the function of clathrin coats in selective transport, genes encoding clathrin-associated proteins (APs) will be cloned and used to generate gene disruptions...
  30. GONOCOCCAL INFECTION AND GENE EXPRESSION IN FEMALE MICE
    Ann E Jerse; Fiscal Year: 2010
    ..Purified cathepsin G (CG) and two antimicrobial peptides (APs) found within PMNs, LL37 and the bactericidal/permeability- increasing protein (BPI), kill Gc in vitro...
  31. Antimicrobial Peptides & Innate Immunity in Otitis Media
    LAUREN BAKALETZ; Fiscal Year: 2006
    Antimicrobial polypeptides (APs) are key components of the primary defense mechanisms of mucus membranes, providing first-line inactivation of bacteria, fungi and viruses on the vast epithelial surfaces that line the respiratory, ..
  32. The Sexual Abuse of Vulnerable Adults in Institutions
    Pamela Teaster; Fiscal Year: 2006
    In 2000, Adult Protective Services (APS), typically the state agency of first contact in cases of abuse, neglect, or exploitation, received 473,095 domestic (in the community) and institutional (nursing homes, assisted living, group ..
  33. Ultrasound-induced Thermal Strain Imaging for Arterial Plaque Characterization
    Kang Kim; Fiscal Year: 2010
    ..alternative imaging technique to non-invasively and reliably identify and characterize atherosclerotic plaques (APs)...