Genomes and Genes
Gene Symbol: SH2B2
Description: SH2B adaptor protein 2
Alias: APS, SH2 and PH domain-containing adapter protein APS, adapter protein with pleckstrin homology and Src homology 2 domains
Publications395 found, 100 shown here
- Adenosine-5'-phosphosulfate kinase from Penicillium chrysogenum: ligand binding properties and the mechanism of substrate inhibitionF Renosto
Department of Biochemistry and Biophysics, University of California, Davis 95616
Arch Biochem Biophys 284:30-4. 199135S]Adenosine-5'-phosphosulfate (APS) binding to Penicillium chrysogenum APS kinase was measured by centrifugal ultrafiltration...
- [Comparison of the characteristics of methacholine and of propranolol in the assessment of aspecific hyperreactivity of the airways]G Schultze-Werninghaus
, Abt. f. Pneumologie, Frankfurt/Main
Pneumologie 45:729-33. 1991..The aerosol was administered by a dosimeter (APS, Jaeger), using doubling concentrations, with a maximum of 25 mg/ml (2.5%), the lowest concentrations being 0...
- Effect of valsartan on angiotensin II- and vasopressin-degrading activities in the kidney of normotensive and hypertensive ratsI Prieto
Unit of Physiology, , Bldg. B3, 23071, , Spain
Horm Metab Res 33:559-63. 2001..Given that aminopeptidases (APs) play a major role in the metabolism of local peptides involved in blood pressure control, studying them helped us ..
- Artificial pulmonary surfactant as a carrier for intratracheally instilled insulinYing Ji
Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, China
Acta Pharmacol Sin 28:744-50. 2007..bioavailabilities and effects on lung injury alleviation of 4 insulin- artificial pulmonary surfactant (INS-APS) preparations were studied in normal rats...
- Tachykinin NK1 but not NK2 receptors mediate non-cholinergic excitatory junction potentials in the circular muscle of guinea-pig colonV Zagorodnyuk
Department Neuro muscular Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
Br J Pharmacol 110:795-803. 1993..j.p.) followed by e.j.p. with superimposed action potentials (APs) and contraction. Addition of either NG-nitro-L-arginine (L-NOARG, 0.1 mM) or apamin (0...
- In-hospital complications among survivors of admission for congestive heart failure, chronic obstructive pulmonary disease, or diabetes mellitusJ M Geraci
Houston Center for Quality of Care and Utilization Studies, Houston Veterans Affairs Medical Center, Baylor College of Medicine 77030, USA
J Gen Intern Med 10:307-14. 1995..9%). Patient age, the presence of comorbid diseases, and the Acute Physiology Score (APS) of APACHE II were associated with complication occurrence...
- Obesity and related metabolic abnormalities during antipsychotic drug administration: mechanisms, management and research perspectivesT Baptista
Los Andes University School of Medicine, Department of Physiology, Merida, Venezuela
Pharmacopsychiatry 35:205-19. 2002Excessive body weight gain (BWG) is a common side effect of some typical and atypical antipsychotic drugs (APs)...
- Probing antiphospholipid-mediated thrombosis: the interplay between anticardiolipin antibodies and endothelial cellsS S Pierangeli
Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia, USA
Lupus 12:539-45. 2003The association of antiphospholipid (aPL) antibodies with thrombosis in patients with antiphospholipid syndrome (APS) is well documented in humans and in animal studies...
- Determinants of risk for venous and arterial thrombosis in primary antiphospholipid syndrome and in antiphospholipid syndrome with systemic lupus erythematosusAdriana Danowski
Rheumatology Department, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 7500, Baltimore MD 21205, USA
J Rheumatol 36:1195-9. 2009Antiphospholipid syndrome (APS) is characterized by thrombosis (venous and arterial) and pregnancy loss in conjunction with the lupus anticoagulant, IgG or IgM anticardiolipin, or IgG or IgM anti-beta2-glycoprotein I...
- Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49C Thollon
Division Pathologies Cardiaques et Vasculaires, Institut de Recherches Servier, Suresnes, France
Br J Pharmacol 112:37-42. 1994..Intracellular recordings of action potentials (APs) were performed with conventional glass microelectrodes. 2...
- Crystal structure of ATP sulfurylase from Penicillium chrysogenum: insights into the allosteric regulation of sulfate assimilationI J MacRae
Section of Molecular and Cellular Biology and Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA
Biochemistry 40:6795-804. 2001..7 kDa subunits (573 residues). The C-terminal allosteric domain of each subunit is homologous to APS kinase...
- Human 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase: biochemistry, molecular biology and genetic deficiencyK V Venkatachalam
Department of Biochemistry, College of Medical Sciences, Health Professions Division, Nova Southeastern University, 3200 South University Dr, Ft Lauderdale, FL 33328 2018, USA
IUBMB Life 55:1-11. 2003..First inorganic sulfate combines with ATP to form adenosine 5'-phosphosulfate (APS) and pyrophosphate catalyzed by ATP sulfurylase domain and in the second step, APS combines with another molecule ..
- Complement activation in patients with primary antiphospholipid syndromeK Oku
Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Ann Rheum Dis 68:1030-5. 2009To investigate the significance of complement activation in patients with primary antiphospholipid syndrome (APS).
- Indoor air pollution by alkylphenols in TokyoI Saito
Department of Environmental Health and Toxicology, Division of Environment Health, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan
Indoor Air 14:325-32. 2004The purposes of this study were to develop an analytical method for airborne alkylphenols (APs) using the gas chromatography/mass spectrometry (GC/MS)-SIM method and to investigate airborne C4-C9 APs pollution in houses, offices, and ..
- Cross-reactivity between anti-cardiolipin, anti-high-density lipoprotein and anti-apolipoprotein A-I IgG antibodies in patients with systemic lupus erythematosus and primary antiphospholipid syndromeJ Delgado Alves
Centre for Rheumatology, Department of Medicine, University College London, London, UK
Rheumatology (Oxford) 42:893-9. 2003..important complication of patients with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). One suggested mechanism may be the action of autoantibodies directed against plasma lipoproteins...
- Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease predictionCorrado Betterle
Chair of Clinical Immunology and Allergy, Department of Medical and Surgical Sciences, University of Padova, I 35128, Padova, Italy
Endocr Rev 23:327-64. 2002..Furthermore, the autoimmune polyglandular syndromes (APS) associated with AD (revised classification, animal models, genetics, natural history) have been discussed...
- Autoantibodies against type I interferons as an additional diagnostic criterion for autoimmune polyendocrine syndrome type IAntonella Meloni
Pediatric Clinic II, Ospedale Microcitemico and Dipartimento di Sciencze Biomediche e Biotechno logiche, University of Cagliari, Cagliari, Sardinia, Italy
J Clin Endocrinol Metab 93:4389-97. 2008In autoimmune polyendocrinopathy syndrome type I (APS-I), mutations in the autoimmune regulator gene (AIRE) impair thymic self-tolerance induction in developing T cells...
- Susceptibility alleles and haplotypes of human leukocyte antigen DRB1, DQA1, and DQB1 in autoimmune polyglandular syndrome type III in Japanese populationKozo Hashimoto
Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Nankoku, Japan
Horm Res 64:253-60. 2005..However, little has been reported on the susceptibility HLA class II haplotypes in Japanese patients with autoimmune polyglandular syndrome type II and type III (APS III).
- Manipulation of thiol contents in plantsR Höfgen
Max Planck Institut fur Molekulare Pflanzenphysiologie, Golm, Federal Republic of Germany
Amino Acids 20:291-9. 2001..relatively inert sulfate molecule is activated through binding to ATP forming adenosine-5'-phosphosulfate (APS). This enzymatic step is controlled through the enzyme ATP-sulfurylase (ATP-S)...
- Non-radioactive adenosine 5'-phosphosulfate sulfotransferase assay by coupling with sulfite reductase and O-acetylserine(thiol)lyaseT Ara
Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University, Japan
Biosci Biotechnol Biochem 61:621-4. 1997Adenosine 5'-phosphosulfate (APS) sulfotransferase is thought to be an enzyme that transfers the sulfo-group of APS to a carrier compound with a thiol group in the assimilatory sulfate reduction pathway of higher plants...
- Photo degradation of methyl orange an azo dye by advanced Fenton process using zero valent metallic iron: influence of various reaction parameters and its degradation mechanismL Gomathi Devi
Department of Post Graduate Studies in Chemistry, Central College City Campus, Bangalore University, Bangalore, India
J Hazard Mater 164:459-67. 2009..of various reaction parameters like effect of iron dosage, concentration of H(2)O(2)/ammonium per sulfate (APS), initial dye concentration, effect of pH and the influence of radical scavenger are studied and optimum conditions ..
- Autoantibodies against phosphatidylserine, prothrombin and phosphatidylserine-prothrombin complex: identical or distinct diagnostic tools for antiphospholipid syndrome?Troy D Jaskowski
Associated Regional and University Pathologists ARUP Institute for Clinical and Experimental Pathology, University of Utah School of Medicine, Salt Lake City, UT, United States
Clin Chim Acta 410:19-24. 2009To clarify the association and diagnostic utility of measuring antiphosphatidyl serine (aPS), antiprothrombin (aPT) and the antiphosphatidyl serine/prothrombin complex (aPS/PT) antibodies in patients with antiphospholipid syndrome (APS) ..
- [Severe neurological and obstetrical complications in a patient with antiphospholipid syndrome]Danuta Bobrowska-Snarska
Klinika Reumatologii Pomorskiej AM w Szczecinie
Pol Arch Med Wewn 115:457-62. 2006Antiphospholipd syndrome (APS) is a disease characterised by venous and arterial thrombosis or recurrent foetal loss, which are associated with antiphospholipid antibodies or/and lupus anticoagulant...
- Homology modeling of dissimilatory APS reductases (AprBA) of sulfur-oxidizing and sulfate-reducing prokaryotesBirte Meyer
Max Planck Institute for Marine Microbiology, Bremen, Germany
PLoS ONE 3:e1514. 2008The dissimilatory adenosine-5'-phosphosulfate (APS) reductase (cofactors flavin adenine dinucleotide, FAD, and two [4Fe-4S] centers) catalyzes the transformation of APS to sulfite and AMP in sulfate-reducing prokaryotes (SRP); in sulfur-..
- Calcium dynamics associated with action potentials in single nerve terminals of pyramidal cells in layer 2/3 of the young rat neocortexH J Koester
Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Jahnstrasse 29, D 69120 Heidelberg, Germany
J Physiol 529:625-46. 2000..Single APs and trains of APs reliably evoked Ca2+ transients in en passant boutons located on axon collaterals in cortical ..
- Specificity and sensitivity of anti-beta2-glycoprotein I as compared with anticardiolipin antibody and lupus anticoagulant in Thai systemic lupus erythematosus patients with clinical features of antiphospholipid syndromeVirunya Parkpian
Division of Allergy, Immunology and Rheumatology, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
Clin Rheumatol 26:1663-70. 2007..I (anti-beta(2)-GPI) have been reported to have stronger association with clinical antiphospholipid syndrome (APS) than anticardiolipin antibodies (aCL) and lupus anticoagulant (LAC)...
- Radiofrequency catheter ablation of right atriofascicular (Mahaim) accessory pathways guided by accessory pathway activation potentialsJ H McClelland
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190
Circulation 89:2655-66. 1994BACKGROUND: Accessory pathways (APs) exhibiting "Mahaim fiber" physiology (antegrade conduction only, long conduction time, and decremental properties) often connect the lateral right atrium to the right bundle branch (right ..
- [Ocular manifestations in patients with systemic lupus erythematosus and antiphospholipid syndrome]Lidia Ostanek
Klinika Reumatologii, Pomorska Akademia Medyczna, Szczecin
Pol Arch Med Wewn 117:18-23. 2007..It could be the reason for many organs and tissues impairment. Changes in eyes that occurr in SLE are not frequent, but can lead to severe impairment of sight including blindness...
- Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domainsEric B Lansdon
Department of Chemistry and Section of Molecular and Cellular Biology, University of California, One Shields Avenue, Davis, California 95616, USA
Biochemistry 43:4356-65. 2004..with each 71 kDa subunit containing an adenosine triphosphate (ATP) sulfurylase and an adenosine 5'-phosphosulfate (APS) kinase domain, catalyzes the overall formation of PAPS from ATP and inorganic sulfate...
- The use of portable computer for information acquirement during anesthesiologist's ward round in acute pain serviceYung Lung Lee
Department of Anesthesiology, Changhua Christian Hospital, Taiwan, ROC
Acta Anaesthesiol Taiwan 45:79-87. 2007..This study was to evaluate the use of PDA for acute pain assessment and compare the PDA-based method with that of the current paper-transcription method in work efficiency...
- Identification of a second lipopolysaccharide in Porphyromonas gingivalis W50Minnie Rangarajan
Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London Queen Mary s School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, United Kingdom
J Bacteriol 190:2920-32. 2008We previously described a cell surface anionic polysaccharide (APS) in Porphyromonas gingivalis that is required for cell integrity and serum resistance...
- The HELLP syndrome in the antiphospholipid syndrome: retrospective study of 16 cases in 15 womenD Le Thi Thuong
Departments of Internal Medicine, Groupe Hospitalier Pitie Salpetriere, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13, France
Ann Rheum Dis 64:273-8. 2005To study the characteristics of the haemolysis, elevated liver enzymes, low platelets (HELLP) syndrome in the antiphospholipid syndrome (APS) and its influence on the subsequent pregnancies.
- Laboratory testing for the antiphospholipid syndrome: making sense of antiphospholipid antibody assaysEmmanuel J Favaloro
Department of Haematology, Institute of Clinical Pathology and Medical Research ICPMR, Westmead Hospital, NSW, Australia
Clin Chem Lab Med 49:447-61. 2011The antiphospholipid syndrome (APS) is an autoimmune condition characterised by a wide range of clinical features (primarily thrombosis and/or obstetric related), associated with the presence of antiphospholipid antibodies (aPL) as ..
- A peptide that shares similarity with bacterial antigens reverses thrombogenic properties of antiphospholipid antibodies in vivoSilvia S Pierangeli
Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Dr SW, Rm 331 BSMB, Atlanta, GA 30310 1495, USA
J Autoimmun 22:217-25. 2004..Peptide A is also found in region I/II of beta2GPI. A scrambled form of peptide A (named scA, GTKGCPNVRLT) was used as a control...
- Novel sequence variation of AIRE and detection of interferon-omega antibodies in early infancyBeáta Tóth
Department of Infectious and Pediatric Immunology, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
Clin Endocrinol (Oxf) 72:641-7. 2010Autoimmune polyendocrine syndrome type I (APS I) is a rare primary immunodeficiency disorder characterized by chronic mucocutaneous candidiasis, multi-organ autoimmunity and ectodermal dysplasia...
- Polysaccharides from Astragalus membranaceus promote phagocytosis and superoxide anion (O2-) production by coelomocytes from sea cucumber Apostichopus japonicus in vitroYongxin Sun
Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian, 116024, People s Republic of China
Comp Biochem Physiol C Toxicol Pharmacol 147:293-8. 2008The potential immunostimulatory effects of Astralagus membranaceus polysaccharides (APS) on sea cucumber, Apostichopus japonicus (Selenka), were investigated in vitro...
- Increased platelet deposition on extracellular matrix under flow conditions in patients with antiphospholipid syndrome who experience thrombotic eventsYair Levy
Meir Medical Center, Kfar Saba, Israel
Arthritis Rheum 52:4011-7. 2005To assess platelet function under defined flow conditions in patients with antiphospholipid syndrome (APS) and to correlate the results with thrombotic complications and the presence of subsets of antiphospholipid antibodies (aPL), lupus ..
- Sulfate-activating enzymes of Penicillium chrysogenum. The ATP sulfurylase.adenosine 5'-phosphosulfate complex does not serve as a substrate for adenosine 5'-phosphosulfate kinaseF Renosto
Department of Biochemistry and Biophysics, University of California, Davis 95616
J Biol Chem 264:9433-7. 1989At a noninhibitory steady state concentration of adenosine 5'-phosphosulfate (APS), increasing the concentration of Penicillium chrysogenum ATP sulfurylase drives the rate of the APS kinase-catalyzed reaction toward zero...
- Phase relation changes between the firings of alpha and gamma-motoneurons and muscle spindle afferents in the sacral micturition centre during continence functions in brain-dead human and patients with spinal cord injuryG Schalow
Electromyogr Clin Neurophysiol 50:3-27. 20101. Single-nerve fibre action potentials (APs) were recorded with 2 pairs of wire electrodes from lower sacral nerve roots during surgery in patients with spinal cord injury and in a brain-dead human...
- Evoked potential studies in the antiphospholipid syndrome: differential diagnosis from multiple sclerosisD Paran
Department of Rheumatology, Tel Aviv Sourasky Medical Centre, Sackler Faculty of Medicine, Tel Aviv University, Israel
Ann Rheum Dis 65:525-8. 2006The CNS manifestations of the antiphospholipid syndrome (APS) can mimic multiple sclerosis both clinically and radiologically.
- [Effects of Astragalus polysaccharides and Cordyceps sinensis mycelium mixture on the transforming growth factor-beta1 expression in chronic rejection of artery transplantation: experiment with rats]Song Zhao
Department of General Surgery, First Affiliated Hospital, Harbin Medical University, Heilongjiang Province, Harbin 150001, China
Zhonghua Yi Xue Za Zhi 87:851-4. 2007To explore the effect of Astragalus polysaccharides (APS) and Cordyceps sinensis (CP) mycelium mixture on the chronic rejection of artery transplantation.
- The antiphospholipid syndrome in pregnant rabbits and their offspring. Neuropathological aspectsPrzemysław Nowacki
Department of Neurology, Pomeranian Medical University, Szczecin, Poland
Folia Neuropathol 43:15-22. 2005Although the obstetric consequences of antiphospholipid syndrome (APS) in pregnant rabbits have been described, there are no data on the serological and neuropathological aspects of the syndrome in their offspring...
- Circulating levels of tissue factor and proinflammatory cytokines in patients with primary antiphospholipid syndrome or leprosy related antiphospholipid antibodiesR R Forastiero
Favaloro University, Favaloro Foundation, Buenos Aires, Argentina
Lupus 14:129-36. 2005The antiphospholipid syndrome (APS) is characterized by the presence of antiphospholipid antibodies (aPL) in patients with thromboembolic complications...
- Ligand-induced structural changes in adenosine 5'-phosphosulfate kinase from Penicillium chrysogenumEric B Lansdon
Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA
Biochemistry 41:13672-80. 2002Adenosine 5'-phosphosulfate (APS) kinase catalyzes the second reaction in the two-step, ATP-dependent conversion of inorganic sulfate to 3'-phosphoadenosine 5'-phosphosulfate (PAPS)...
- The isolation and characterization of cDNA encoding the mouse bifunctional ATP sulfurylase-adenosine 5'-phosphosulfate kinaseH Li
Department of Pediatrics, University of Chicago, Illinois 60637, USA
J Biol Chem 270:29453-9. 1995..action of two enzyme activities: ATP sulfurylase, which catalyzes the formation of adenosine 5'-phosphosulfate (APS) from ATP and free sulfate, and APS kinase, which subsequently phosphorylates APS to produce adenosine 3'-phosphate ..
- A novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathwayW Cao
Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, 169 West Changle Road, Xi an, Shaanxi 710032, China
Phytomedicine 17:598-605. 2010A novel polysaccharide isolated from Angelica sinensis, named APS-1d showed cytotoxic activity towards several cancer cell lines in vitro. However, the precise antitumor mechanisms of this compound are unknown...
- A cost-utility and cost-effectiveness analysis of an acute pain serviceMichaela Stadler
Department of Anesthesiology, University Hospital Center, Charleroi, Belgium
J Clin Anesth 16:159-67. 2004To analyze, from a societal perspective, the cost-effectiveness and cost-utility of acute pain management after inception of a nurse-based Acute Pain Service (APS) in a general hospital.
- An acute pain service improves postoperative pain management for children undergoing selective dorsal rhizotomyChantal Frigon
Department of Anesthesiology, McGill University Health Center, Montreal Children s Hospital, Montreal, QC, Canada
Paediatr Anaesth 19:1213-9. 2009..The aim of the study was to evaluate the impact of having an organized acute pain service (APS) on postoperative pain management of these children.
- Antiphospholipid syndrome nephropathy in patients with systemic lupus erythematosus and antiphospholipid antibodies: prevalence, clinical associations, and long-term outcomeMaria G Tektonidou
Department of Pathophysiology, School of Medicine, National University of Athens, Athens, Greece
Arthritis Rheum 50:2569-79. 2004To evaluate the prevalence, clinical associations, and outcome of antiphospholipid syndrome (APS) nephropathy in patients with systemic lupus erythematosus (SLE) and antiphospholipid antibodies (aPL) and in SLE patients without aPL.
- Protective effects of emodin and astragalus polysaccharides on chronic hepatic injury in ratsShuang Suo Dang
Department of Infectious Diseases, The Second Hospital of Xi an Jiaotong University, Xi an, Shaanxi, China
Chin Med J (Engl) 121:1010-4. 2008Chinese medicine plays an important role in hepatoprotective treatment. This study was conducted to investigate the protective effects of emodin and astragalus polysaccharides (APS) in a rat model of chronic hepatic injury.
- Astragalus polysaccharides: an effective treatment for diabetes prevention in NOD miceW Chen
Department of Geriatrics, Huashan Hospital, Fudan University of Shangai, China
Exp Clin Endocrinol Diabetes 116:468-74. 2008..Astragalus polysaccharides (APS) are bioactive components extracted from one of the traditional Chinese herbs, used to enhance the function of ..
- Arterialisation of the portal vein as a model for the induction of hepatic fibrosis: description of microsurgical models in the ratVolker Muller
Department of Surgery, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
Transpl Int 17:822-33. 2005..inserted in the right renal artery (PVA-B), the second with unrestricted flow using an aortic-portal segment (PVA-APS). The third technique was orthotopic liver transplantation with unrestricted portal arterialisation (OLTx-APS)...
- Clusters of disease manifestations in patients with antiphospholipid syndrome demonstrated by factor analysisI Krause
Department of Medicine E, Rabin Medical Center, Beilinson Campus, Israel
Lupus 16:176-80. 2007The antiphospholipid syndrome (APS) is now recognized as a multi-system disease, the clinical expression of which may include various target-organs involvements...
- Factor XIII in primary antiphospholipid syndromePaul R J Ames
Academic Department of Rheumatology, Leeds General Infirmary, Leeds, UK
J Rheumatol 32:1058-62. 2005To evaluate the clinical significance of factor XIII (FXIII) in primary antiphospholipid syndrome (APS).
- Modulation of Ca(2+)-activated K+ currents and Ca(2+)-dependent action potentials by exocytosis in goldfish bipolar cell terminalsMary J Palmer
Neuroscience Group, Institute for Science and Technology in Medicine, Keele University, Keele ST5 5BG, UK
J Physiol 572:747-62. 2006..They do not fire Na(+)-dependent action potentials (APs) but the Mb1 class of goldfish bipolar cell exhibits Ca(2+)-dependent APs and regenerative potentials that ..
- Novel autoantibodies against the activated coagulation factor IX (FIXa) in the antiphospholipid syndrome that interpose the FIXa regulation by antithrombinYao Hsu Yang
Division of Rheumatology, Department of Medicine, University of California, Los Angeles, CA 90095, USA
J Immunol 182:1674-80. 2009We previously reported that some human antiphospholipid Abs (aPL) in patients with the antiphospholipid syndrome (APS) bind to the homologous enzymatic domains of thrombin and the activated coagulation factor X (FXa)...
- Use of a new silica clotting time for diagnosing lupus anticoagulant in patients who meet the clinical criteria for antiphospholipid syndromePanagiotis Grypiotis
Rheumatology Unit, University of Padova, Padova, Italy
J Clin Lab Anal 20:15-8. 2006..a new commercial SCT for identifying LA in patients who meet the clinical criteria for antiphospholipid syndrome (APS), and its association with thrombotic events were evaluated here...
- Oligonucleotide model with non-identical complementary strands for chromatographic studies of structure-dependent photosusceptibilityV N Potaman
Department of Biology, George Mason University, Fairfax, VA 22030
J Chromatogr A 690:65-70. 1995..F6 and the ordinary antiparallel-stranded (aps) F5.F7 duplexes...
- Evaluating laboratory approaches to the identification of lupus anticoagulants: a diagnostic challenge from the RCPA Haematology QAPRoslyn Bonar
Royal College of Pathologists of Australasia RCPA Haematology Quality Assurance Program QAP, Northmead, NSW, Australia
Pathology 44:240-7. 2012..LA), an important component of the clinical diagnosis of the autoimmune disorder antiphospholipid syndrome (APS), is challenged by the heterogeneity of tests available, the diagnostic and laboratory approach undertaken, and the ..
- A thermodynamic study of GPI-anchored and soluble form of alkaline phosphatase films at the air-water interfaceFrédéric Ronzon
Laboratoire de Physico Chimie Biologique, UMR 5013, Universite Claude Bernard Lyon I, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex, France
J Colloid Interface Sci 301:493-502. 2006..They can also exist as soluble proteins without anchor (APs)...
- Preconcentration method on modified silica fiber for chromium speciationVarinder Kaur Chahal
Chemistry Department, Panjab University, Chandigarh 160 014
J Chromatogr Sci 50:26-32. 2012..Both complexes are extracted on silica fiber modified by sol-gel technology by using 3-aminopropyltriethoxysilane (APS) as a precursor...
- Amplitude-dependent spike-broadening and enhanced Ca(2+) signaling in GnRH-secreting neuronsF Van Goor
Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 USA
Biophys J 79:1310-23. 2000..shift in the firing pattern and its impact on Ca(2+) influx experimentally by using prerecorded sharp and broad APs as the voltage-clamp command pulse...
- [Effects of angelica polysaccharides on the proliferation of mouse skeletal muscle satellite cells and the expression of stem cell factor receptor protein]Xiao Ling Wang
Department of Histology and Embryology, College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin
Zhongguo Zhong Xi Yi Jie He Za Zhi 32:93-6. 2012To observe the effects of angelica polysaccharides (APS) on the proliferation of mouse skeletal muscle satellite cells (MSCs) and c-kit expression in different in vitro hematopoietic microenvironments.
- Respiratory syncytial virus-induced dysregulation of expression of a mucosal beta-defensin augments colonization of the upper airway by non-typeable Haemophilus influenzaeGlen McGillivary
The Research Institute at Nationwide Children s Hospital, Center for Microbial Pathogenesis, The Ohio State University College of Medicine, Columbus, Ohio 43205, USA
Cell Microbiol 11:1399-408. 2009..that effectors of innate immunity regulate normal bacterial colonization of the NP and, further, virus-induced altered expression of APs can result in an increased load of NTHI within the NP, which likely promotes development of OM.
- [Experimental research of astragalus polysaccharides collagen sponge in enhancing angiogenesis and collagen synthesis]Chang Yao
Department of Breast Surgery, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing Jiangsu 210029, PR China
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 25:1481-5. 2011Astragalus polysaccharide (APS) has promoting angiogenesis function...
- Renal manifestations of the antiphospholipid syndromeD P D'Cruz
The Lupus Research Unit, The Rayne Institute St Thomas Hospital, London, UK
Lupus 14:45-8. 2005..manifestations have been reported since the earliest descriptions of the antiphospholipid (Hughes) syndrome (APS). The spectrum of clinical features associated with antiphospholipid nephropathy continues to widen...
- Stroke and antiphospholipid syndrome: the treatment debateG Ruiz-Irastorza
Servicio de Medicina Interna, Hospital de Cruces, 48903 Bizkaia, Spain
Rheumatology (Oxford) 44:971-4. 2005Antiphospholipid syndrome (APS) is one of the most frequent acquired thrombophilias. Thromboses can be at both the venous and arterial level, are usually recurrent and frequently affect cerebral circulation...
- Muscarinic acetylcholine receptors enhance neonatal mouse hypoglossal motoneuron excitability in vitroMatthew F Ireland
School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia
J Appl Physiol (1985) 113:1024-39. 2012..Muscarinic agonists reduced the afterhyperpolarization of single action potentials (APs), suggesting that small-conductance Ca(2+)-dependent K(+) current inhibition increased the HM firing rate...
- Possible selves and academic outcomes: How and when possible selves impel actionDaphna Oyserman
The Institute for Social Research, The University of Michigan, Ann Arbor, MI 48106 1248, USA
J Pers Soc Psychol 91:188-204. 2006..in pursuing APSs (n = 141 experimental, n = 123 control low-income 8th graders) increased success in moving toward APS goals: academic initiative, standardized test scores, and grades improved; and depression, absences, and in-school ..
- Thrombotic events during long-term follow-up of obstetric antiphospholipid syndrome patientsG Lefevre
Department of Internal Medicine, National Reference Centre for Systemic Sclerosis, University Hospital, Universite Lille Nord de France, Lille, France
Lupus 20:861-5. 2011Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by arterial and/or venous thromboses and/or pregnancy-associated morbidity...
- The confusion assessment method--a tool for delirium detection by the acute pain serviceZeev Friedman
Department of Anesthesia and Pain Management, Mount Sinai Hospital, University of Toronto, Canada
Pain Pract 8:413-6. 2008..The purpose of this pilot study was to assess the feasibility in terms of required time and yield of delirium monitoring by the Acute Pain Service (APS) using the Confusion Assessment Method for Intensive Care Unit instrument.
- Thrombotic microangiopathy and the antiphospholipid syndromeS J A Johnsen
Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Norway
Lupus 19:1569-72. 2010The antiphospholipid syndrome (APS) comprises the association between vascular thrombosis, including microthrombosis, pregnancy morbidity and the coexistence of anti-phospholipid antibodies...
- Enhancement of the innate immune response of bladder epithelial cells by Astragalus polysaccharides through upregulation of TLR4 expressionXiaolin Yin
Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan Province 610041, China
Biochem Biophys Res Commun 397:232-8. 2010..In this study, cultured 5637 cells and Balb/C mice were treated with Astragalus polysaccharides (APS) against invading E. coli...
- Molecular weight and monosaccharide composition of Astragalus polysaccharidesDu Juan Xu
Department of Pharmacy, First Affiliated Hospital of Anhui Medical University, Hefei, 230022 PR China
Molecules 13:2408-15. 2008Two polysaccharides (APS-I and APS-II) were isolated from the water extract of Radix Astragali and purified through ethanol precipitation, deproteination and by ion-exchange and gel-filtration chromatography...
- Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptidesSusana Sanchez-Gomez
Department of Microbiology and Parasitology, University of Navarra, 31080 Pamplona, Spain
BMC Microbiol 8:196. 2008..have prompted the development of alternative therapies like those based on cationic antimicrobial peptides (APs). These compounds not only are bactericidal by themselves but also enhance the activity of antibiotics...
- The association of anti-parvovirus B19-VP1 unique region antibodies with antiphospholipid antibodies in patients with antiphospholipid syndromeDer Yuan Chen
Department of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
Clin Chim Acta 411:1084-9. 2010Human parvovirus B19 (B19) infection has been identified as a trigger of antiphospholipid syndrome (APS). However, the precise role of B19-VP1 unique region (VP1u) in patients with antiphospholipid syndrome remains unclear.
- In vitro and in vivo degradation of poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate) elastomersChristopher J Bettinger
Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room E25 342, Cambridge, Massachusetts 02139, USA
J Biomed Mater Res A 91:1077-88. 2009..on the amine alcohol 1,3-diamino-2-hydroxypropane termed poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate) or APS. In this work, we have synthesized and characterized formulations of APS polymers and studied the degradation of ..
- Exploiting proteomic data for genome annotation and gene model validation in Aspergillus nigerJames C Wright
Dept Veterinary Preclinical Sciences, University of Liverpool, Liverpool, UK
BMC Genomics 10:61. 2009..from 1d gel electrophoresis bands and searched against all available gene models using Average Peptide Scoring (APS) and reverse database searching to produce confident identifications at an acceptable false discovery rate (FDR).
- Venous thromboembolism: the intricaciesT K Dutta
Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605 006, India
J Postgrad Med 55:55-64. 2009..Thrombotic events associated with antiphospholipid syndrome (APS) are 70% venous and 30% arterial...
- Pulmonary autoimmunity as a feature of autoimmune polyendocrine syndrome type 1 and identification of KCNRG as a bronchial autoantigenMohammad Alimohammadi
Department of Medical Sciences, University Hospital, Uppsala University, 751 85 Uppsala, Sweden
Proc Natl Acad Sci U S A 106:4396-401. 2009Patients with autoimmune polyendocrine syndrome type 1 (APS-1) suffer from multiple organ-specific autoimmunity with autoantibodies against target tissue-specific autoantigens...
- Alkylphenols in marine environments: distribution monitoring strategies and detection considerationsArthur David
UMR 5569 Hydrosciences Montpellier, Universite Montpellier I, 15 Avenue Charles Flahault, B P 14491 34093, Montpellier, France
Mar Pollut Bull 58:953-60. 2009The presence of alkylphenols (APs) in coastal and marine ecosystems is not as well-documented as it is in freshwater ecosystems...
- Kallikreins and proteinase-mediated signaling: proteinase-activated receptors (PARs) and the pathophysiology of inflammatory diseases and cancerMorley D Hollenberg
Proteinases and Inflammation Network, Department of Pharmacology and Therapeutics, University of Calgary Faculty of Medicine, Calgary T2N 4N1, AB, Canada
Biol Chem 389:643-51. 2008..Work with synthetic TL-derived PAR peptide sequences (PAR-APs) that stimulate PARs 1, 2 and 4 has shown that PAR activation can play a role in many tissues, including the ..
- [Structural analysis and anti-tumor activity in vivo of polysaccharide APS-2a from Angelica sinensis]Wei Cao
Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi an 710032, China
Zhong Yao Cai 31:261-6. 2008The polysaccharide APS-2a was isolated from Angelica sinensis (Oliv...
- Effects of membrane depolarization and changes in extracellular [K(+)] on the Ca (2+) transients of fast skeletal muscle fibers. Implications for muscle fatigueMarbella Quiñonez
Laboratorio de Fisiología y Biofisíca del Músculo, IBE, UCV, Caracas, Venezuela
J Muscle Res Cell Motil 31:13-33. 2010..Potentiation was inversely correlated with a reduction in the amplitude, overshoot and duration of APs. Similar effects were found for the Ca(2+) transients elicited by the first pulse of 100 Hz trains...
- Evaluation of dialyzer jacket structure and hollow-fiber dialysis membranes to achieve high dialysis performanceAyaka Hirano
School of Advanced Science and Engineering, Waseda University, Tokyo, Japan
Ther Apher Dial 15:66-74. 2011..the clearance, dialysate, and blood flow for four commercially available hollow-fiber dialyzers, namely, the APS-15S, APS-15SA, TS-1.6UL, and CX-1.6U...
- Venous limb gangrene and fatal hemorrhage: adverse consequences of HIT "overdiagnosis" in a patient with antiphospholipid syndromeMaureen A Smythe
Department of Pharmaceutical Services, Beaumont Hospitals, Royal Oak, Michigan 48073, USA
Am J Hematol 86:188-91. 2011..positive" tests for HIT antibodies, the low pretest probability for HIT and the known propensity of patients with APS to yield false-positive HIT antibody results suggests that the patient did not have a true diagnosis of HIT...
- Genotype Ser413/Ser of PAI-2 polymorphism Ser413/Cys is associated with anti-phospholipid syndrome and systemic lupus erythematosus in a familial case: comparison with healthy controlsM Vazquez-Del Mercado
Institute for Rheumatology and Muscle Skeletal Research, University of Guadalajara, Mexico
Scand J Rheumatol 36:206-10. 2007..a 7-year-old proband case diagnosed with systemic lupus erythematosus (SLE) plus secondary anti-phospholipid syndrome (APS) as well as two affected paternal aunts. We compared the frequency of these polymorphisms with healthy controls.
- Are clerical workers proletarian? A case study of the Australian Public ServiceCraig Matheson
Flinders Institute of Public Policy and Management, Flinders University
Br J Sociol 58:577-602. 2007This paper explores whether clerical workers have been proletarianized by using the Australian Public Service (APS) as a case study...
- Antiphospholipid syndrome and vascular ischemic (occlusive) diseases: an overviewPenka A Atanassova
Department of Neurology, Medical University, 15A V Aprilov Blvd, Plovdiv, 4000, Bulgaria
Yonsei Med J 48:901-26. 2007Antiphospholipid syndrome (APS) is primarily considered to be an autoimmune pathological condition that is also referred to as "Hughes syndrome"...
- Amputation of digits or limbs in patients with antiphospholipid syndromeRonald A Asherson
Division of Immunology, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa
Semin Arthritis Rheum 38:124-31. 2008To describe the characteristics of patients with peripheral vascular disease leading to amputation of digits or limbs encountered in patients with the antiphospholipid syndrome (APS).
- Evaluation of the hypothalamic-pituitary-adrenal axis in patients with antiphospholipid syndromeP Rotman-Pikielny
Department of Medicine E, Kfar Saba, Israel, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Int J Clin Pract 64:1398-401. 2010..HPA) axis insufficiency is the most common endocrine disorder in patients with antiphospholipid syndrome (APS)...
- Ictus and antiphospholipid syndrome: how much is enough?Elena Rodríguez-Castellano
Servicio de Medicina Interna, Hospital Universitario La Paz, P de la Castellana, 261 28046 Madrid, Spain
Autoimmunity 41:140-2. 2008Herein we report the case of a patient with antiphospholipid Syndrome (APS) and an ischemic stroke suffered while he was anticoagulated, and we discuss the usefulness of magnetic resonance angiography in the early diagnosis of such a ..
- Beta2-glycoprotein I protects thrombin from inhibition by heparin cofactor II: potentiation of this effect in the presence of anti-beta2-glycoprotein I autoantibodiesSoheila Rahgozar
Department of Immunology, Allergy and Infectious Diseases, University of New South Wales, Sydney, New South Wales, Australia
Arthritis Rheum 58:1146-55. 2008Beta2-glycoprotein I (beta2GPI) is an important autoantigen in the antiphospholipid syndrome (APS)...
- [Antiphospholipid antibodies and cancer]M L Scrobohaci
Laboratoire Central d Hématologie, Hopital Saint Louis, 1, avenue Claude Vellefaux, 75010 Paris, France
Pathol Biol (Paris) 56:245-50. 2008..The antiphospholipid syndrome (APS) is a form of immune mediated thrombophilia occurring as a recurrent thrombotic event in association with positive ..
- Adult zebrafish heart as a model for human heart? An electrophysiological studyPetros Nemtsas
Biotechnology Center and Center for Regenerative Therapies, Dresden University of Technology, Dresden, Germany
J Mol Cell Cardiol 48:161-71. 2010..Here, we characterize action potentials (APs) from intact adult atria and ventricles and find that the overall shape of zebrafish APs is similar to that of ..
- Identification and quantification of estrogen receptor agonists in wastewater effluentsS A Snyder
Department of Zoology, National Food Safety and Toxicology Center, Michigan State University, East Lansing 48824 1311, USA
Environ Sci Technol 35:3620-5. 2001..5% of the total estrogen equivalents in the water samples analyzed. Concentrations of alkylphenols (APs) ranged from nondetectable to 148 microg/mL extract (nondetectable to 37,000 ng/L water)...
- IgG anti-beta(2) glycoprotein I antibodies in Malaysian patients with antiphospholipid syndrome and systemic lupus erythematosus: prevalence and clinical correlationsS G Ong
University of Malaya, Kuala Lumpur, Malaysia
Clin Rheumatol 21:382-5. 2002..glycoprotein I antibody (anti-beta2GPI) positivity in patients with primary or secondary antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE), to assess the association between IgG ACL and anti-beta2GPI, and the ..
- A pilot open-label phase II trial of rituximab for non-criteria manifestations of antiphospholipid syndromeDoruk Erkan
Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery and Weill Medical College of Cornell University, New York, New York, USA
Arthritis Rheum 65:464-71. 2013..in antiphospholipid antibody (aPL)-positive patients with non-criteria manifestations of antiphospholipid syndrome (APS)...
- Prevalence of pain among residents in Japanese nursing homes: a descriptive studyYukari Takai
Department of Gerontological Nursing, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan
Pain Manag Nurs 14:e1-9. 2013..in older adults living in nursing homes in Japan by using self-reporting and the Abbey Pain Scale-Japanese version (APS-J) and to explore factors related to pain. This is a descriptive study...
- Electric activity of the colon in subjects with constipation due to total colonic inertia: an electrophysiologic studyAhmed Shafik
Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, Cairo, Egypt
Arch Surg 138:1007-11; discussion 1011. 2003..colon exhibits electric activity in the form of slow waves or pacesetter potentials (PPs) and action potentials (APs), which are coupled with elevated colonic pressure. The APs are claimed to be responsible for colonic motor activity...
- Efficacy of aspirin for the primary prevention of thrombosis in patients with antiphospholipid antibodies: an international and collaborative meta-analysisLaurent Arnaud
Department of Internal Medicine, French National Reference Center for Systemic Lupus and Antiphospholipid Syndrome, AP HP, Groupe Hospitalier Pitie Salpetriere, 47 83 Bd de l Hopital, 75013 Paris, France Institut National de la Santé et de la Recherche Médicale INSERM, UMR S 945, Paris, France Université Pierre et Marie Curie, UPMC Univ Paris 06, Paris, France Electronic address
Autoimmun Rev 13:281-91. 2014..25-0.99]), for systemic lupus erythematosus (SLE) (OR: 0.55 [0.31-0.98]) and obstetrical antiphospholipid syndrome (APS) (OR: 0.25 [0.10-0.62])...
- ANTIPHOSPHOLIPID ANTIBODIES IN THROMBOSISReginald Chukwuocha; Fiscal Year: 2000..including recurrent thrombosis, fetal loss, thrombocytopenia and cerebral involvement ("Antiphospholipid syndrome", APS) in systemic lupus erythematous (SLE) are associated with the production of anticardiolipin antibodies (ACA) and ..
- Predictors of Pregnancy Outcome in SLE and APSJane E Salmon; Fiscal Year: 2012Pregnancy complications in women with the antiphospholipid syndrome (APS) and/or SLE include recurrent miscarriage, preeclampsia, placental insufficiency, and intrauterine growth restriction (IUGR)...
- Antiphospholipid antibodies and lupus: new molecular targets for treatmentEmilio B Gonzalez; Fiscal Year: 2013..thrombosis and pregnancy loss in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). Thrombosis is an important cause of morbidity and mortality in APS and SLE patients with aPL Abs...
- ANTICARDIOLIPIN ANTIBODIES AND OXIDIZED PHOSPHOLIPIDSJoseph Witztum; Fiscal Year: 2004Patients with the antiphospholipid antibody syndrome (APS) have autoantibodies to certain phospholipids (aPL) such as cardiolipin and/or the lupus anticoagulant and clinically experience recurrent venous or arterial thrombosis, history ..
- THERAPY WITH ANNEXINS FOR ANTIPHOSPHOLIPID SYNDROMEMARIA BEGONA CAMPOS NACIFF; Fiscal Year: 2004DESCRIPTION: (Scanned from the applicant's description): APS is a disorder characterized by venous and arterial thrombosis, recurrent fetal loss, thrombocytopenia and by the presence of antiphospholipid antibodies...
- Discovery of Novel Interventions of the Antiphospholipid SyndromeChieko Mineo; Fiscal Year: 2013DESCRIPTION (provided by applicant): The antiphospholipid syndrome (APS) is an autoimmune disease characterized by a markedly increased risk of thromboses and cardiovascular diseases resulting from elevated levels of circulating ..
- NOVEL BIOMARKERS FOR MECHANISTIC DIAGNOSIS OF THE ANTIPHOSPHOLIPID SYNDROMEJACOB RAND; Fiscal Year: 2010..and therapeutic responses for blood and vascular dysfunction - specifically, the antiphospholipid syndrome (APS) an autoimmune thrombotic condition that is reported to be responsible for ~10% of patients with venous ..
- Anti-Phospholipid Multiplex For Pathologic EpitopesPaul O Neilsen; Fiscal Year: 2010..provided by applicant): This project will help delineate the true nature of antigens in antiphospholipid syndrome (APS)...
- TREATMENT STRATEGIES FOR THE ANTI PHOSPHOLIPID SYNDROMEJOHN DEDMAN; Fiscal Year: 2003Antiphospholipid Syndrome (APS), also known as Hughes Syndrome, is a multiorgan vascular disease associated with myocardial infarction, stroke thrombosis and recurrent fetal loss...
- ANTIPHOSPHOLIPID SYNDROME REGISTRY (APSCORE)Robert Roubey; Fiscal Year: 2000This contract is for a Registry and Repository for Antiphospholipid Syndrome (APS) that will enable investigators to identify basic immunological and genetic abnormalities, pathophysiological mechanisms contributing to thrombosis, fetal ..
- Investigation of Beta2-glycoprotein I Complexes in Antiphospholipid SyndromeNatalia Beglova; Fiscal Year: 2013DESCRIPTION (provided by applicant): Antiphospholipid syndrome (APS) is an autoimmune disease characterized clinically by thrombosis and/or recurrent fetal loss...
- Mechanisms of aPL antibody-induced pregnancy lossJane Salmon; Fiscal Year: 2005The antiphospholipid syndrome (APS), characterized by thrombosis and pregnancy loss that occurs in the presence of antiphospholipid (aPL) antibodies, is a leading cause of miscarriage and maternal and fetal morbidity...
- Regulation of the anti-phospholipid response in SLEAnne Davidson; Fiscal Year: 2013..PUBLIC HEALTH RELEVANCE: Antiphospholipid syndrome (APS) is a devastating autoimmune condition that causes recurrent blood clots and has no effective treatment apart from ..
- Post-9/11 Incidence of Systemic Autoimmune Diseases in the FDNY CohortMayris P Webber; Fiscal Year: 2013..The following SAID diagnoses will be included: systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis (SSc;both diffuse and limited), inflammatory myositis (dermatomyositis, polymyositis, or ..
- Isolation of Autoantibodies to Apoptotic CellsMarko Radic; Fiscal Year: 2004..evidence links the initiation and progression of Systemic Lupus Erythematosus (SLE) and Anti-Phospholipid Syndrome (APS) to aberrant immune responses to apoptotic cells...
- ANTIPHOSPHOLIPID ANTIBODIES AND DISORDERS OF PREGNANCYNeal Rote; Fiscal Year: 2000..previous studies have demonstrated that mouse monoclonal and human polyclonal antiphosphatidylserine antibodies (aPS) bind directly to antigens on trophoblast, both villous and extravillous...
- Excitation-contraction Coupling in Normal and Dystrophic Mammalian MuscleJulio L Vergara; Fiscal Year: 2013..We have found that Ca2+ release evoked by action potentials (APs) (or voltage-clamp pulses) in muscle fibers from two of such models, the adult mdx mouse and the phenotypic ..
- EXPRESSION AND FUNCTION OF K+ CHANNEL GENES IN BRAINBernardo Rudy; Fiscal Year: 2013..known as the fast-spiking (FS) cell, named for its ability to fire sustained trains of action potentials (APs) at remarkably high frequencies...
- Role of P2Y Receptors and Activated Platelets in InflammationANALIA E GARCIA; Fiscal Year: 2012..show that Clopidogrel treatment, that dampens platelet activation, aggravates the inflammatory responses in a PG-APS -induced arthritis in a rat model...
- Synaptic plasticity, EtOH and backpropagating action potentials in NAccGilles E Martin; Fiscal Year: 2010..We hypothesize that LTD results from the interactions between synaptic potentials and backpropagating (b-APs), and that b-APs mediate EtOH effects on LTD...
- EtOH Modulation of Synaptic Plasticity in Nucleus AccumbensGilles E Martin; Fiscal Year: 2013..model of plasticity called Spike-Timing-Dependent Plasticity (STDP) that relies on pairing of action potentials (APs) and excitatory postsynaptic potentials (EPSP) at in vivo-like frequencies (~ 1Hz)...
- Action Potential Signaling in Axons of CNS InterneuronsJason M Christie; Fiscal Year: 2013..are compiled at the soma, and are then transmitted to synaptic output sites on the axon as action potentials (APs) following initiation in the axon initial segment (AIS)...
- Depth-resolved Optical Imaging of Neural Action PotentialsTaner Akkin; Fiscal Year: 2013..We also utilized the technology for depth- localization of APs in axons stained with voltage-sensitive dyes, and constructed highly sensitivity polarization-sensitive systems for ..
- OPTO-ELECTRIC MAPPING OF ACTION POTENTIALSIgor R Efimov; Fiscal Year: 2013..Alternatively, optical mapping technology permits recordings of tens of thousands of APs from the epicardium or endocardium, yet it has been used solely for in vitro studies and has not yet been ..
- The role of atypical PKCs in sensitization of sensory neurons by NGFGrant D Nicol; Fiscal Year: 2013..demonstrated that NGF/BDNF can rapidly increase the ability of sensory neurons to fire action potentials (APs) via p75 neurotrophin receptor (p75NTR) activation of the sphingolipid signaling cascade...
- TEMPORAL PRECISION AND DYNAMICAL CODING IN THE OLFACTORY BULBRichard C Gerkin; Fiscal Year: 2012..Because of this speed limit, the precise timing of action potentials (APs) will not track rapid, millisecond-timescale changes in stimulus properties as in other sensory systems...
- A method for diffraction-limited spot measurements of membrane potential in situThomas S Otis; Fiscal Year: 2013..have limited photoxicity, and the speed and sensitivity required for detection of individual action potentials (APs) in single neurons...
- Antigen Identification in a Novel Model of Spontaneous Autoimmune Ovarian DiseaseMickie H Cheng; Fiscal Year: 2012..for the Autoimmune Regulator (AIRE) gene, a gene first identified in the human Autoimmune Polyglandular Syndrome (APS) type 1...
- Mechanism of aPL antibody-induced Pregnancy lossJane E Salmon; Fiscal Year: 2010DESCRIPTION (provided by applicant): The antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy loss that occur in the presence of antiphospholipid (aPL) antibodies...
- Reduction of Annexin A5 in Antipholipid Pregnancy LossJACOB RAND; Fiscal Year: 2010Recurrent pregnancy losses are a hallmark of the antiphospholipid syndrome (APS), a complicated major hypercoagulable disorder without an established mechanism that is currently diagnosed with phenomenologic surrogate tests...
- AUTOIMMUNE MECHANISMS OF THROMBOSISRobert Roubey; Fiscal Year: 2004The Antiphospholipid Syndrome (APS) represents an interface between the immune system and blood coagulation...
- ANTICARDIOLIPIN ANTIBODIES IN ANTIPHOSPHOLIPID SYNDROMEPojen Chen; Fiscal Year: 2007..are to identify and characterize pathogenic anticardiolipin antibodies (aCL) in the antiphospholipid syndrome (APS)...
- Conference on Autonomic Regulation of Cardiovascular Function in Health and DiseaMartin Frank; Fiscal Year: 2012..This American Physiological Society (APS) conference will focus on many of these mechanisms...
- The molecular mechanism of Aire: partnering with DNA-PKDiane J Mathis; Fiscal Year: 2013..focuses on the molecular mechanisms of Aire, the protein encoded by the gene mutated in individuals with APECED (or APS-1), a primary immunodeficiency disease characterized by multi-organ autoimmunity...
- Antimicrobial Peptides and Innate Immunity in Otitis MediaLauren O Bakaletz; Fiscal Year: 2012..Antimicrobial peptides (APs) are key components of the innate immune system, providing first-line inactivation of microbes on the vast ..
- SK channels: Roles and mechanisms for dendritic excitability and plasticityJames G Maylie; Fiscal Year: 2012..manner, and serve as bi-directional regulators of intrinsic excitability by limiting retrograde b-APs and electrotonic propagation of dendritic EPSPs...
- Role of ROS-Induced DNA Damage in Mitochondria-Regulated ApoptosisAnne Tann; Fiscal Year: 2012..In addition to oxidatively damaging proteins and lipids, ROS also cause DNA damage, such as mutagenic abasic sites (APS) and their oxidized derivatives (OAS), in nuclear and mitochondrial DNA, which have implications for the induction ..
- ANATOMY AND PHARMACOLOGY OF FEAR-POTENTIATED STARTLEMICHAEL NMN DAVIS; Fiscal Year: 2010..Here we will determine whether treatments that block (local APS or Map kinase inhibitors in Bla) or facilitate (D-cyclpserine given systemically or directly into Bla) will alter ..
- Factors that Initiate Arrhythamias in Long QT SyndromeGuy Salama; Fiscal Year: 2006..will be perfused, stained with voltage and Ca 2+ - sensitive dyes to simultaneously map action potentials (APs) and intracellular Ca 2v(Cai) transients from 256 sites at high spatial and temporal resolution...
- Structural Analysis of the GPI Transamidase ComplexAnant K Menon; Fiscal Year: 2012DESCRIPTION (provided by applicant): Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) are ubiquitous in eukaryotes...
- KALLIKREIN KININ SYSTEM IN INFLAMMATORY BOWEL DISEASERobert Colman; Fiscal Year: 2001We have shown that bacterial products (proteoglycan-polysaccharide, PG- APS) found in the lower bowel produce chronic granulomatous inflammation similar to Crohn's disease (regional ileitis) in genetically susceptible rats as well as ..
- GONOCOCCAL INFECTION AND GENE EXPRESSION IN FEMALE MICEAnn E Jerse; Fiscal Year: 2013..Purified cathepsin G (CG) and two antimicrobial peptides (APs) found within PMNs, LL37 and the bactericidal/permeability- increasing protein (BPI), kill Gc in vitro...
- Effects of K+ Accumulation/Depletion in the HeartGuy Salama; Fiscal Year: 2013..In perfused hearts, APs and [K+]a will be simultaneously mapped, and changes in [K+]a will be measured on a beat-to-beat basis...
- Secretagogue induced mechanisms regulating islet electrical activityDAVID AARON JACOBSON; Fiscal Year: 2012..whole islet current clamp recordings in combination with high speed calcium imaging to measure changes in APs and calcium fluctuations caused by glucose, GLP-1, and phosphatase regulation. 2...
- Nanoprobe for High Resolution Hard X-ray Fluorescence MicroscopyGayle E Woloschak; Fiscal Year: 2010..installed at the beamline of the Life Sciences Collaborative Access Team (LS-CAT) at the Advanced Photon Source (APS) at Argonne National Laboratory (ANL)...
- Chemistry and Biology of Bacterial Sulfonucleotide ReductasesKATE SUZANNE CARROLL; Fiscal Year: 2013..cysteine biosynthesis, sulfonucleotide reductases (SRs) catalyze the reduction of 5'-phosphosulfoadenosine (APS) or 3'-phospho-5'phosphosulfoadenosine (PAPS) to sulfite using reducing equivalents from a protein ..
- GONOCOCCAL INFECTION AND GENE EXPRESSION IN FEMALE MICEANN JERSE; Fiscal Year: 2009..Purified cathepsin G (CG) and two antimicrobial peptides (APs) found within PMNs, LL37 and the bactericidal/permeabilityincreasing protein (BPI), kill Gc in vitro...
- Innate Immunity in Experimental Arthritis of KininogenRobert Colman; Fiscal Year: 2007..Parenterally injected peptidoglycanpolysaccharide complexes (PG-APS) induce a systemic inflammatory response consisting of erosive polyarthritis, hepatic granulomas, and anemia...
- Ultrasound-induced Thermal Strain Imaging for Arterial Plaque CharacterizationKang Kim; Fiscal Year: 2013..alternative imaging technique to non-invasively and reliably identify and characterize atherosclerotic plaques (APs)...
- Deaf1 isoforms control changes in PTA expression in the NOD PLN during T1D pathogCHARLES GARRISON FATHMAN; Fiscal Year: 2013..or a lack of regulatory T cell development? Finally, do either mouse models of autoimmune uveoretinitis or human APS 1 patients have changes in Deaf1 that can be correlated with disease? The results of these studies will provide an ..
- SALMONELLA ANTIMICROBIAL PEPTIDE RESISTANCEJohn S Gunn; Fiscal Year: 2013..A key component of the innate immune system in these locations are antimicrobial peptides (APs): ubiquitous proteins that destroy bacterial membranes. PhoP-PhoQ (PhoPQ) and PmrA-PmrB (PmrAB) are Salmonella spp...
- Directed hematopoietic differentiation of human pluripotent stem cellsLinzhao Cheng; Fiscal Year: 2013..and gives rise to large numbers of blood cells lacking glycosyl-phosphatidyl- inositol anchored proteins (GPI-APs)...
- Bright and Fast Sensor for Time Resolved X-Ray Diffraction StudiesVIVEK V NAGARKAR; Fiscal Year: 2010..specially developed high-speed readout by RMD and evaluated at the BioCAT beam line at the Advanced Photon Source (APS) at ANL, to demonstrate their performance superiority compared to current state-of-the- art scintillator screens...
- Survival of Neisseria gonorrhoeae after primary human neutrophil challengeAlison K Criss; Fiscal Year: 2013..animals other than humans and by the inability of PMN-derived cell lines to make many antimicrobial proteins (APs)...
- Gender-Differences in Cardiac Repolarization/ArrhythmiasGuy Salama; Fiscal Year: 2005..Optical maps of APs and Cai transients q selective blockers for IKr, IKs and ICa will elucidate gender differences in the spatial ..
- Bioactive Compounds from the Biodiversity of Vietnam and LaosDjaja D Soejarto; Fiscal Year: 2010..These six APs will operate under the coordination of the GROUP PROGRAM based at UIC...
- Interactive Program to Manage and Prevent Back PainA Blair Irvine; Fiscal Year: 2013..NLBP) that does not require medical attention, the American College of Physicians (ACP) and American Pain Society (APS) recommend a multidisciplinary approach to pain management that integrates cognitive, physical, and educational ..
- Repair of Endogenous Damage in Mammalian GenomesSankar Mitra; Fiscal Year: 2011DESCRIPTION (provided by applicant): Mutagenic and toxic abasic sites (APS) and their oxidized derivatives (OAS), implicated in induction of sporadic cancer, are endogenously generated in the nuclear and mitochondrial genomes of ..
- Control Systems for Artificial Pancreas Use During and After ExerciseAli Cinar; Fiscal Year: 2013..The project aims are to develop multivariable control and hypoglycemia early warning systems for APs that will be safe to use during and after various types of exercise and group sports for patients with diabetes, to ..
- Mechanisms of Sap-mediated Antimicrobial Peptide ResistanceMargaret E Bauer; Fiscal Year: 2012DESCRIPTION (provided by applicant): Antimicrobial peptides (APs), including defensins and cathelicidins, are an important component of the innate immune system for combating bacteria and other microbial invaders...
- AIRE, a zinc-finger protein that controls autoimmunityDiane J Mathis; Fiscal Year: 2013..Mutations in the AIRE gene underlie a rare multi-organ autoimmune disease called APECED or APS-1, and abnormalities in the Aire-pathway have also been implicated in certain of the more common autoimmune ..
- Closed-loop Artificial Pancreas: Algorithm Engineering and Clinical EvaluationHoward Zisser; Fiscal Year: 2013..a continuous glucose sensor, a continuous subcutaneous insulin infusion pump, and artificial pancreas software (APS)...
- BioCARS: A Synchroton Structural Biology ResourceJOHN KEITH MOFFAT; Fiscal Year: 2011..that exploits the distinctive features of BioCARS and complements other structural biology beamlines at the APS and nationally...
- Database designed novel anti-MRSA peptidesGuangshun Wang; Fiscal Year: 2013..we have been constructing, expanding, and updating the widely used Antimicrobial Peptide Database (APD;http://aps.unmc.edu/AP/main.html)...
- Magnetic Resonance Spectroscopy in the Psychosis Risk SyndromeStephan F Taylor; Fiscal Year: 2013..Individuals with an 'attenuated psychosis syndrome'(APS) present with low levels of reality distortion (unusual thought content, perceptual aberrations, suspiciousness/..
- APS STEP-UP: Promoting Diversity Through Research Experiences and Professional SoMarsha Lakes Matyas; Fiscal Year: 2013DESCRIPTION (provided by applicant): The APS STEP-UP project will help undergraduate students from groups underrepresented in biomedicine to 1) increase their understanding of and exposure to careers in biomedical research, 2) ..
- BioCARS: A Synchroton Structural Biology ResourceJOHN KEITH MOFFAT; Fiscal Year: 2012..that exploits the distinctive features of BioCARS and complements other structural biology beamlines at the APS and nationally...
- Position tracking and mobility assessment system for indoor monitoring of eldersEric A Wan; Fiscal Year: 2013..The system consists of multiple wireless access points (APs) positioned throughout the home, an (optional) small wireless tag worn by the individual, a hub that aggregates the ..
- "Mixtures of Xenoestrogens Alter Estradiol-induced Non-Genomic Signaling"René Viñas; Fiscal Year: 2013..Alkylphenols (APs;nonylphenol (NP) and the structurally related bisphenol-A (BPA)) are known XEs that have been detected in ..
- ANTIPROGESTINS IN ENDOMETRIUMRONALD WIEHLE; Fiscal Year: 2000..and the NICHD was finalized to develop new 19-substituted-norprogestins. New antiprogestins (APs) discovered by NICHD and realized as drugs through this SBIR, would bring the results of government-sponsored ..
- The Sexual Abuse of Vulnerable Adults in InstitutionsPamela Teaster; Fiscal Year: 2006DESCRIPTION (provided by applicant): In 2000, Adult Protective Services (APS), typically the state agency of first contact in cases of abuse, neglect, or exploitation, received 473,095 domestic (in the community) and institutional (..
- High-Speed, Depth-Resolved Images of Cardiac physiologyGuy Salama; Fiscal Year: 2007..Waggoner and Ernst will synthesize new longer wavelength fluorescent dyes to monitor action potentials (APs) or cytosolic free Ca2+(Cai) and Dr...