SGT1

Summary

Gene Symbol: SGT1
Description: SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
Alias: SGT1, protein SGT1 homolog, SGT1, suppressor of G2 allele of SKP1, suppressor of G2 allele of SKP1, S. cerevisiae, homolog of
Species: human
Products:     SGT1

Top Publications

  1. Lee Y, Jacob J, Michowski W, Nowotny M, Kuznicki J, Chazin W. Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain. J Biol Chem. 2004;279:16511-7 pubmed
    b>Sgt1 has been identified as a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes and is also implicated in plant disease resistance...
  2. Zhang M, Boter M, Li K, Kadota Y, Panaretou B, Prodromou C, et al. Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes. EMBO J. 2008;27:2789-98 pubmed publisher
    b>Sgt1 is an adaptor protein implicated in a variety of processes, including formation of the kinetochore complex in yeast, and regulation of innate immunity systems in plants and animals...
  3. Bansal P, Abdulle R, Kitagawa K. Sgt1 associates with Hsp90: an initial step of assembly of the core kinetochore complex. Mol Cell Biol. 2004;24:8069-79 pubmed
    ..In budding yeast, Sgt1, together with Skp1, is required for assembly of the core kinetochore complex (CBF3) via Ctf13 activation...
  4. da Silva Correia J, Miranda Y, Leonard N, Ulevitch R. SGT1 is essential for Nod1 activation. Proc Natl Acad Sci U S A. 2007;104:6764-9 pubmed
    ..Extensive genetic studies have shown that the R protein function is determined by multiple proteins including SGT1, Rar1, and HSP90. Here we show that SGT1 positively regulates Nod1 activation...
  5. Steensgaard P, Garrè M, Muradore I, Transidico P, Nigg E, Kitagawa K, et al. Sgt1 is required for human kinetochore assembly. EMBO Rep. 2004;5:626-31 pubmed
    Budding yeast Sgt1 is required for kinetochore assembly, and its homologues have a role in cAMP signalling in fungi and pathogen resistance in plants. The function of mammalian Sgt1 is unknown...
  6. Mayor A, Martinon F, De Smedt T, Petrilli V, Tschopp J. A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses. Nat Immunol. 2007;8:497-503 pubmed
    ..Here we show that many NLRs interacted with the ubiquitin ligase-associated protein SGT1 and heat-shock protein 90 (HSP90), both of which have plant orthologs essential for R-protein responses...
  7. Auweter S, Bhavsar A, de Hoog C, Li Y, Chan Y, van der Heijden J, et al. Quantitative mass spectrometry catalogues Salmonella pathogenicity island-2 effectors and identifies their cognate host binding partners. J Biol Chem. 2011;286:24023-35 pubmed publisher
    ..The technology outlined in this study is specific and sensitive and serves as a robust tool for the identification of effectors and their host targets that is readily amenable to the study of other bacterial pathogens. ..
  8. Niikura Y, Ohta S, Vandenbeldt K, Abdulle R, McEwen B, Kitagawa K. 17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation. Oncogene. 2006;25:4133-46 pubmed
    ..We found that HSP90 associates with SGT1 (suppressor of G2 allele of skp1; SUGT1) in human cells and that depletion of SGT1 sensitizes HeLa cells to 17-AAG...
  9. Kitagawa K, Skowyra D, Elledge S, Harper J, Hieter P. SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. Mol Cell. 1999;4:21-33 pubmed
    We have identified SGT1 as a dosage suppressor of skp1-4, a mutation causing defects in yeast kinetochore function. Sgt1p physically associates with Skp1p in vivo and in vitro...

More Information

Publications63

  1. Shepherd L, Hackett C, Alexander C, McNicol J, Sungurtas J, Stewart D, et al. Modifying glycoalkaloid content in transgenic potato--Metabolome impacts. Food Chem. 2015;187:437-43 pubmed publisher
    ..been genetically modified (GM) to reduce glycoalkaloid content, via the independent down-regulation of three genes SGT1, SGT2 and SGT3 known to be involved in glycoalkaloid biosynthesis...
  2. Stankeviciute G, Guan Z, Goldfine H, Klein E. Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid. MBio. 2019;10: pubmed publisher
    ..we identify three proteins required for GSL-2 synthesis: CcbF catalyzes the first step in ceramide synthesis, while Sgt1 and Sgt2 sequentially glycosylate ceramides to produce GSL-2...
  3. Dong Z, Li W, Liu J, Li L, Pan S, Liu S, et al. The Rice Phosphate Transporter Protein OsPT8 Regulates Disease Resistance and Plant Growth. Sci Rep. 2019;9:5408 pubmed publisher
    ..In OsPT8-OX plants, PAMPs-triggered immunity (PTI) response genes, such as OsRac1 and SGT1, are suppressed during treatment with PAMPs chitin or flg22...
  4. Cantu D, Yang B, Ruan R, Li K, Menzo V, Fu D, et al. Comparative analysis of protein-protein interactions in the defense response of rice and wheat. BMC Genomics. 2013;14:166 pubmed publisher
    ..As entry points we selected proteins that serve as key regulators of the rice defense response: the RAR1/SGT1/HSP90 protein complex, NPR1, XA21, and XB12 (XA21 interacting protein 12)...
  5. Qian X, Xiang Q, Yang T, Ma H, Ding X, Tao X. Molecular Co-Chaperone SGT1 Is Critical for Cell-to-Cell Movement and Systemic Infection of Tomato Spotted Wild Virus in Nicotiana benthamiana. Viruses. 2018;10: pubmed publisher
  6. Wang G, Fan R, Wang X, Wang D, Zhang X. TaRAR1 and TaSGT1 associate with TaHsp90 to function in bread wheat (Triticum aestivum L.) seedling growth and stripe rust resistance. Plant Mol Biol. 2015;87:577-89 pubmed publisher
    RAR1 and SGT1 are important co-chaperones of Hsp90. We previously showed that TaHsp90.1 is required for wheat seedling growth, and that TaHsp90.2 and TaHsp90...
  7. Kumar D, Kirti P. Pathogen-induced SGT1 of Arachis diogoi induces cell death and enhanced disease resistance in tobacco and peanut. Plant Biotechnol J. 2015;13:73-84 pubmed publisher
    We have identified a transcript derived fragment (TDF) corresponding to SGT1 in a study of differential gene expression on the resistant wild peanut, Arachis diogoi, upon challenge from the late leaf spot pathogen, Phaeoisariopsis ..
  8. Chapman S, Stevens L, Boevink P, Engelhardt S, Alexander C, Harrower B, et al. Detection of the virulent form of AVR3a from Phytophthora infestans following artificial evolution of potato resistance gene R3a. PLoS ONE. 2014;9:e110158 pubmed publisher
    ..We demonstrated that R3a*-mediated recognition responses, like for R3a, are dependent on SGT1 and HSP90...
  9. Ogi H, Sakuraba Y, Kitagawa R, Xiao L, Shen C, Cynthia M, et al. The oncogenic role of the cochaperone Sgt1. Oncogenesis. 2015;4:e149 pubmed publisher
    b>Sgt1/Sugt1, a cochaperone of Hsp90, is involved in several cellular activities including Cullin E3 ubiqutin ligase activity...
  10. Pausch H, Schwarzenbacher H, Burgstaller J, Flisikowski K, Wurmser C, Jansen S, et al. Homozygous haplotype deficiency reveals deleterious mutations compromising reproductive and rearing success in cattle. BMC Genomics. 2015;16:312 pubmed publisher
    ..Our results provide the basis for genome-assisted approaches to avoiding inadvertent carrier matings and to improving reproductive and rearing success in Fleckvieh cattle. ..
  11. Redkar A, Hoser R, Schilling L, Zechmann B, Krzymowska M, Walbot V, et al. A Secreted Effector Protein of Ustilago maydis Guides Maize Leaf Cells to Form Tumors. Plant Cell. 2015;27:1332-51 pubmed publisher
    ..See1 interacts with a maize homolog of SGT1 (Suppressor of G2 allele of skp1), a factor acting in cell cycle progression in yeast (Saccharomyces cerevisiae) ..
  12. Kim S, Lee H, Choi E, Park E, Kim J, Moon K, et al. Coiled-coil and leucine-rich repeat domain of the potyvirus resistance protein, Pvr4, has distinct role in signaling and pathogen recognition. Mol Plant Microbe Interact. 2018;: pubmed publisher
    ..Molecular chaperone components including HSP90, SGT1 and RAR1 were required, while plant hormones and mitogen-activated protein (MAP) kinase signaling components had ..
  13. Moshe A, Gorovits R, Liu Y, Czosnek H. Tomato plant cell death induced by inhibition of HSP90 is alleviated by Tomato yellow leaf curl virus infection. Mol Plant Pathol. 2016;17:247-60 pubmed publisher
    ..We show that the chaperone HSP90 (heat shock protein 90) and its co-chaperone SGT1 (suppressor of the G2 allele of Skp1) are involved in the establishment of TYLCV infection...
  14. Aguilar E, Almendral D, Allende L, Pacheco R, Chung B, Canto T, et al. The P25 protein of potato virus X (PVX) is the main pathogenicity determinant responsible for systemic necrosis in PVX-associated synergisms. J Virol. 2015;89:2090-103 pubmed publisher
    ..Moreover, we show that silencing of SGT1 and RAR1 attenuated cell death in both PVX-potyvirus synergistic infection and the HR-like response elicited by P25...
  15. Yang Y, Zhou Q, Chen X, Yan B, Guo X, Zhang H, et al. Profiling of differentially expressed genes in sheep T lymphocytes response to an artificial primary Haemonchus contortus infection. Parasit Vectors. 2015;8:235 pubmed publisher
    ..contortus infection. Our results provide a substantial list of candidate genes in sheep T lymphocytes response to H. contortus infection, and contribute novel insights into a general immune response upon infection. ..
  16. Shepherd L, Hackett C, Alexander C, McNicol J, Sungurtas J, McRae D, et al. Impact of light-exposure on the metabolite balance of transgenic potato tubers with modified glycoalkaloid biosynthesis. Food Chem. 2016;200:263-73 pubmed publisher
    ..cv. Desirée) with reduced glycoalkaloid content via the down-regulation of the SGT1 gene...
  17. Djami Tchatchou A, Ncube E, Steenkamp P, Dubery I. Similar, but different: structurally related azelaic acid and hexanoic acid trigger differential metabolomic and transcriptomic responses in tobacco cells. BMC Plant Biol. 2017;17:227 pubmed publisher
    ..acids metabolism, while ethylene response element-binding protein, small sar1 GTPase, heat shock protein 90, RAR1, SGT1, non-expressor of PR genes 1 and thioredoxin were analyzed to report on signal transduction events...
  18. Xiang J, Li X, Yin L, Liu Y, Zhang Y, Qu J, et al. A candidate RxLR effector from Plasmopara viticola can elicit immune responses in Nicotiana benthamiana. BMC Plant Biol. 2017;17:75 pubmed publisher
    ..Suppressor of G-two allele of Skp1 (SGT1), heat shock protein 90 (HSP90) and required for Mla12 resistance (RAR1), but not somatic embryogenesis receptor-..
  19. Cheol Song G, Sim H, Kim S, Ryu C. Root-mediated signal transmission of systemic acquired resistance against above-ground and below-ground pathogens. Ann Bot. 2016;: pubmed
    ..Plants with knock-down of the multiple resistance component SGT1 and SA biosynthesis-related gene ICS1 by Tobacco rattle virus-mediated virus-induced gene silencing exhibited a ..
  20. Martinez Noel G, Luck K, Kühnle S, Desbuleux A, Szajner P, Galligan J, et al. Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes. J Mol Biol. 2018;430:1024-1050 pubmed publisher
  21. Kosová K, Chrpová J, Santrucek J, Hynek R, Štěrbová L, Vitamvas P, et al. The effect of Fusarium culmorum infection and deoxynivalenol (DON) application on proteome response in barley cultivars Chevron and Pedant. J Proteomics. 2017;169:112-124 pubmed publisher
    ..enzymes), amino acid metabolism (aminotransferases), defence response (chitinase, xylanase inhibitor, serpins, SGT1, universal stress protein USP), protein folding (chaperones, chaperonins), redox metabolism (ascorbate-glutathione ..
  22. He W, Zheng X, Zhang Y, Gao Y, Song A, van der Goot F, et al. Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone. PLoS ONE. 2016;11:e0147515 pubmed publisher
    ..USP19_b directly interacts with HSP90 through its N-terminal CS (CHORD and SGT1)/P23 domains...
  23. Wang H, Ren Y, Zhou J, Du J, Hou J, Jiang R, et al. The Cell Death Triggered by the Nuclear Localized RxLR Effector PITG_22798 from Phytophthora infestans Is Suppressed by the Effector AVR3b. Int J Mol Sci. 2017;18: pubmed publisher
    ..infestans infection. PITG_22798-triggered cell death is dependent on SGT1-mediated signaling and is suppressed by the P. infestans avirulence effector 3b (AVR3b)...
  24. Yusof N, Hashim N, Beddoe T, Mahadi N, Illias R, Bakar F, et al. Thermotolerance and molecular chaperone function of an SGT1-like protein from the psychrophilic yeast, Glaciozyma antarctica. Cell Stress Chaperones. 2016;21:707-15 pubmed publisher
    ..These results suggest that GaSGT1 promotes cell thermotolerance and employs molecular chaperone-like activity toward temperature assaults. ..
  25. Tavares R, Wajnberg G, Scherer N, Pauletti B, Cassoli J, Ferreira C, et al. Unveiling alterative splice diversity from human oligodendrocyte proteome data. J Proteomics. 2017;151:293-301 pubmed publisher
    ..Our findings may contribute to oligodendrocyte characterization and encourage other research groups to investigate the biological role of splice variants and to improve current treatments and diagnostic methods for CNS disorders. ..
  26. Willhoft O, Kerr R, Patel D, Zhang W, Al Jassar C, Daviter T, et al. The crystal structure of the Sgt1-Skp1 complex: the link between Hsp90 and both SCF E3 ubiquitin ligases and kinetochores. Sci Rep. 2017;7:41626 pubmed publisher
    The essential cochaperone Sgt1 recruits Hsp90 chaperone activity to a range of cellular factors including SCF E3 ubiquitin ligases and the kinetochore in eukaryotes...
  27. Wang R, Zhang Y, Kieffer M, Yu H, Kepinski S, Estelle M. HSP90 regulates temperature-dependent seedling growth in Arabidopsis by stabilizing the auxin co-receptor F-box protein TIR1. Nat Commun. 2016;7:10269 pubmed publisher
    ..In addition, we show that HSP90 and the co-chaperone SGT1 each interact with TIR1, confirming that TIR1 is an HSP90 client...
  28. Liu Z, Liu Y, Shi L, Yang S, Shen L, Yu H, et al. SGT1 is required in PcINF1/SRC2-1 induced pepper defense response by interacting with SRC2-1. Sci Rep. 2016;6:21651 pubmed publisher
    ..Herein, we describe the involvement of SGT1 in the PcINF1/SRC2-1-induced immunity...
  29. Tran P, Choi H, Choi D, Kim K. Virus-induced gene silencing reveals signal transduction components required for the Pvr9-mediated hypersensitive response in Nicotiana benthamiana. Virology. 2016;495:167-72 pubmed publisher
    ..Our results show that the Pvr9-mediated HR against pepper mottle virus infection requires HSP90, SGT1, NDR1, but not EDS1...
  30. Kapustian L, Vigontina O, Rozhko O, Ryabenko D, Michowski W, Leśniak W, et al. Hsp90 and its co-chaperone, Sgt1, as autoantigens in dilated cardiomyopathy. Heart Vessels. 2013;28:114-9 pubmed
    ..this work we focused on the involvement of another wellknown heat shock protein, Hsp90, and its novel co-chaperone,Sgt1, in dilated cardiomyopathy (DCM)...
  31. Martins T, Sunkel C. Sgt1 plays polo during cell division. Cell Cycle. 2009;8:1110-1 pubmed
  32. Novosylna O, Jurewicz E, Pydiura N, Góral A, Filipek A, Negrutskii B, et al. Translation elongation factor eEF1A1 is a novel partner of a multifunctional protein Sgt1. Biochimie. 2015;119:137-45 pubmed publisher
    ..Here, we identified a novel partner of the eEF1A1 isoform, namely Sgt1, a protein that possesses co-chaperon properties and participates in antiviral defense processes...
  33. Eastburn D, ZEGERS M, Mostov K. Scrib regulates HGF-mediated epithelial morphogenesis and is stabilized by Sgt1-HSP90. J Cell Sci. 2012;125:4147-57 pubmed publisher
    ..We show a novel association between the leucine-rich repeat domain of Scrib and the co-chaperone Sgt1 and demonstrate that these proteins are necessary for epithelial morphogenesis and tubulogenesis following ..
  34. Prus W, Filipek A. S100A6 mediates nuclear translocation of Sgt1: a heat shock-regulated protein. Amino Acids. 2011;41:781-7 pubmed publisher
    b>Sgt1 was originally identified in yeast as a suppressor of the Skp1 protein. Later, it was found that Sgt1 is present in plant and mammalian organisms and that it binds other ligands such as S100A6, a calcium-binding protein...
  35. Bhavsar A, Brown N, Stoepel J, Wiermer M, Martin D, Hsu K, et al. The Salmonella type III effector SspH2 specifically exploits the NLR co-chaperone activity of SGT1 to subvert immunity. PLoS Pathog. 2013;9:e1003518 pubmed publisher
    ..phenotypes required its catalytic E3 ubiquitin ligase activity and interaction with the conserved host protein SGT1. SGT1 has an essential cell cycle function and an additional function as an NLR co-chaperone in animal and plant ..
  36. Davies A, Kaplan K. Hsp90-Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore-microtubule binding sites. J Cell Biol. 2010;189:261-74 pubmed publisher
    ..The Hsp90-Sgt1 chaperone complex is important for this process; however, its targets are not conserved and its exact contribution ..
  37. Spiechowicz M, Zylicz A, Bieganowski P, Kuznicki J, Filipek A. Hsp70 is a new target of Sgt1--an interaction modulated by S100A6. Biochem Biophys Res Commun. 2007;357:1148-53 pubmed
    In this work, we identified Hsp70 as a novel target of the Sgt1 protein. Using co-immunoprecipitation, affinity chromatography and ELISA we showed that, besides Hsp90, Sgt1 interacts with the heat shock protein, Hsp70...
  38. Góral A, Bieganowski P, Prus W, Krzemień Ojak Ł, Kądziołka B, Fabczak H, et al. Calcyclin Binding Protein/Siah-1 Interacting Protein Is a Hsp90 Binding Chaperone. PLoS ONE. 2016;11:e0156507 pubmed publisher
    ..Since CacyBP/SIP shares some sequence homology with a known Hsp90 co-chaperone, Sgt1, in this work we performed a set of experiments in order to verify whether CacyBP/SIP can interact with Hsp90...
  39. Hong T, Hahn J. Application of SGT1-Hsp90 chaperone complex for soluble expression of NOD1 LRR domain in E. coli. Biochem Biophys Res Commun. 2016;478:1647-52 pubmed publisher
    ..Based on the fact that Hsp90 and its cochaperone SGT1 are necessary for the stabilization and activation of NOD1 in mammals, SGT1 was chosen as a fusion partner of the ..
  40. Zabka M, Leśniak W, Prus W, Kuznicki J, Filipek A. Sgt1 has co-chaperone properties and is up-regulated by heat shock. Biochem Biophys Res Commun. 2008;370:179-83 pubmed publisher
    The Sgt1 protein is a binding partner of heat shock proteins such as Hsp90, Hsp70 or Hsc70. In this work we show that the level of Sgt1 is increased in HEp-2 cells exposed to heat shock or radicicol...
  41. Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J. Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins. J Biol Chem. 2003;278:26923-8 pubmed
    ..A recently discovered yeast homolog of CacyBP/SIP, Sgt1, associates with Skp1 and regulates its function in the Skp1/Cullin1/F-box complex ubiquitin ligase and in ..
  42. Iwatsuki M, Mimori K, Sato T, Toh H, Yokobori T, Tanaka F, et al. Overexpression of SUGT1 in human colorectal cancer and its clinicopathological significance. Int J Oncol. 2010;36:569-75 pubmed
    ..The amplification of SUGT1 might give rise to promote the transcription of the gene directly subsequent to the progression of CRC cases with worsening prognosis. ..
  43. Zou X, Ji C, Wang L, Wu M, Zheng H, Xu J, et al. Molecular cloning and characterization of SGT1.2, a novel splice variant of Homo sapiens SGT1. DNA Seq. 2004;15:140-3 pubmed
    b>SGT1.2, a novel splice variant of Homo sapiens SGT1 was isolated from a human fetal brain cDNA library. This cDNA is 1404 bp and contains an open reading frame from 68 to 1165 encoding a putative protein of 365 amino acids (SGT1...
  44. Li D, Shen F, Li H, Li W. Kale BoRACK1 is involved in the plant response to salt stress and Peronospora brassicae Gaumann. J Plant Physiol. 2017;213:188-198 pubmed publisher
    ..Yeast two-hybrid assays showed that BoRACK1 could interact with WNK8, eIF6, RAR1, and SGT1. This study and previous work lead us to believe that BoRACK1 may form a complex with regulators of plant salt and ..
  45. Bansal P, Mishra A, High A, Abdulle R, Kitagawa K. Sgt1 dimerization is negatively regulated by protein kinase CK2-mediated phosphorylation at Ser361. J Biol Chem. 2009;284:18692-8 pubmed publisher
    ..In budding yeast, Sgt1 and Hsp90 are required for the binding of Skp1 to Ctf13 (a component of the core kinetochore complex CBF3) and ..
  46. Park S, Cheong M, Kim E, Kim J, Chi Y, Jang M. Antifungal Effect of Arabidopsis SGT1 Proteins via Mitochondrial Reactive Oxygen Species. J Agric Food Chem. 2017;65:8340-8347 pubmed publisher
    The highly conserved SGT1 (suppressor of the G2 alleles of skp1) proteins from Arabidopsis are known to contribute to plant resistance to pathogens...
  47. Zhu X, Xiao K, Cui H, Hu J. Overexpression of the Prunus sogdiana NBS-LRR Subgroup Gene PsoRPM2 Promotes Resistance to the Root-Knot Nematode Meloidogyne incognita in Tobacco. Front Microbiol. 2017;8:2113 pubmed publisher
    ..R proteins require the co-chaperone protein HSP90-SGT1-RAR1 to achieve correct folding, maturation, and stabilization...
  48. Liu X, Song B, Tang J, Liu W, Kuang S, Liu X. Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment. Mol Cell Biol. 2012;32:4053-67 pubmed publisher
    ..Here we identify Sgt1, a cochaperone for Hsp90, as a novel Plk1 substrate during mitosis...
  49. Piwko W, Olma M, Held M, Bianco J, Pedrioli P, Hofmann K, et al. RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells. EMBO J. 2010;29:4210-22 pubmed publisher
    ..Together, our results strongly suggest that the Mms22L-Nfkbil2 complex contributes to genome stability by regulating the chromatin state at stalled replication forks. ..
  50. Hong T, Kim S, Wi A, Lee P, Kang M, Jeong J, et al. Dynamic nucleotide-dependent interactions of cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1 and melusin with cochaperones PP5 and Sgt1. J Biol Chem. 2013;288:215-22 pubmed publisher
    ..Furthermore, we demonstrate that Chp-1 and melusin can interact with cochaperones PP5 and Sgt1 and with each other in an ATP-dependent manner...
  51. Niikura Y, Kitagawa K. Identification of a novel splice variant: human SGT1B (SUGT1B). DNA Seq. 2003;14:436-41 pubmed
    We identified a novel splice variant of human SGT1 (SUGT1), a suppressor of the G2 allele of SKP1, by analysis of 8 human EST clones whose open reading frame encoded 365 amino acids...
  52. Gao G, Kun T, Sheng Y, Qian M, Kong F, Liu X, et al. SGT1 regulates Akt signaling by promoting beta-TrCP-dependent PHLPP1 degradation in gastric cancer cells. Mol Biol Rep. 2013;40:2947-53 pubmed publisher
    b>SGT1 (suppressor of G2 allele of Skp1) plays a role in various cellular processes including kinetochore assembly and protein ubiquitination by interacting with Skp1, a component of SCF E3 ligase complex...
  53. Gangula N, Maddika S. Interplay between the phosphatase PHLPP1 and E3 ligase RNF41 stimulates proper kinetochore assembly via the outer-kinetochore protein SGT1. J Biol Chem. 2017;292:13947-13958 pubmed publisher
    ..We found that PHLPP1 interacted with the essential outer-kinetochore protein SGT1 and stabilized its protein levels...
  54. Prus W, Zabka M, Bieganowski P, Filipek A. Nuclear translocation of Sgt1 depends on its phosphorylation state. Int J Biochem Cell Biol. 2011;43:1747-53 pubmed publisher
    Recently we have shown that the Sgt1 (suppressor of G2 allele of Skp1) protein translocates to the nucleus due to heat shock and that the Ca(2+)-bound form of S100A6 is required for Sgt1 translocation (Prus and Filipek, 2010)...