SGPL1

Summary

Gene Symbol: SGPL1
Description: sphingosine-1-phosphate lyase 1
Alias: NPHS14, S1PL, SPL, sphingosine-1-phosphate lyase 1, SP-lyase 1, SPL 1, hSPL, sphingosine-1-phosphate aldolase
Species: human
Products:     SGPL1

Top Publications

  1. Van Veldhoven P, Mannaerts G. Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver. J Biol Chem. 1991;266:12502-7 pubmed
    ..Treatment of intact microsomal vesicles with trypsin or thermolysin inactivated the lyase activity, confirming that its catalytic site(s) or other domains essential for activity face the cytosol. ..
  2. Reiss U, Oskouian B, Zhou J, Gupta V, Sooriyakumaran P, Kelly S, et al. Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. J Biol Chem. 2004;279:1281-90 pubmed
  3. Oskouian B, Sooriyakumaran P, Borowsky A, Crans A, Dillard Telm L, Tam Y, et al. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer. Proc Natl Acad Sci U S A. 2006;103:17384-9 pubmed
    ..S1P is irreversibly degraded by the enzyme S1P lyase (SPL). In this study, we show a crucial role for SPL in mediating cellular responses to stress...
  4. Vogel P, Donoviel M, Read R, Hansen G, Hazlewood J, Anderson S, et al. Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions. PLoS ONE. 2009;4:e4112 pubmed publisher
    b>S1PL is an aldehyde-lyase that irreversibly cleaves sphingosine 1-phosphate (S1P) in the terminal step of sphingolipid catabolism...
  5. Brizuela L, Ader I, Mazerolles C, Bocquet M, Malavaud B, Cuvillier O. First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer. Mol Cancer Ther. 2012;11:1841-51 pubmed publisher
    This is the first report of sphingosine 1-phosphate lyase (SPL) protein expression and enzymatic activity in human neoplasm...
  6. Wasilewska E, Zlotkowska D, Wroblewska B. Yogurt starter cultures of Streptococcus thermophilus and Lactobacillus bulgaricus ameliorate symptoms and modulate the immune response in a mouse model of dextran sulfate sodium-induced colitis. J Dairy Sci. 2019;102:37-53 pubmed publisher
    ..IgA antibody-forming cells were downregulated in mesenteric lymph nodes (MLN) and enhanced in spleens (SPL)...
  7. Scotti L, Di Pietro M, Pascuali N, Irusta G, I de Zúñiga -, Gomez Peña M, et al. Sphingosine-1-phosphate restores endothelial barrier integrity in ovarian hyperstimulation syndrome. Mol Hum Reprod. 2016;22:852-866 pubmed
    ..01) and S1P lyase (SPL; P < 0.05) and increased the levels of S1PR1 (P < 0.05) in endothelial cells...
  8. Lecomte M, Bourlieu C, Meugnier E, Penhoat A, Cheillan D, Pineau G, et al. Milk Polar Lipids Affect In Vitro Digestive Lipolysis and Postprandial Lipid Metabolism in Mice. J Nutr. 2015;145:1770-7 pubmed publisher
    ..In mice, after 1 h, plasma TGs tended to be higher in the MPL group than in the SPL group (141 μg/mL vs. 90 μg/mL; P = 0...
  9. Olatunji L, Adeyanju O, Michael O, Usman T, Tostes R, Soladoye A. Ameliorative effect of low-dose spironolactone on obesity and insulin resistance is through replenishment of estrogen in ovariectomized rats. Can J Physiol Pharmacol. 2018;: pubmed publisher
    ..Ten weeks old female Wistar rats were divided into four groups; sham-operated (SHM), spironolactone (SPL; 0.25 mg/kg) and ovariectomized (OVX) rats treated with or without spironolactone daily for 8 weeks...

More Information

Publications144 found, 100 shown here

  1. Kapolowicz M, Thompson L. Acute high-intensity noise induces rapid Arc protein expression but fails to rapidly change GAD expression in amygdala and hippocampus of rats: Effects of treatment with D-cycloserine. Hear Res. 2016;342:69-79 pubmed publisher
    ..was evaluated in male rats 45 min after bilateral exposure to acute high-intensity noise (16 kHz, 115 dB SPL, for 1 h), sufficient to cause acute cochlear trauma, a common cause of tinnitus in humans and previously shown ..
  2. Saminathan T, Bodunrin A, Singh N, Devarajan R, Nimmakayala P, Jeff M, et al. Genome-wide identification of microRNAs in pomegranate (Punica granatum L.) by high-throughput sequencing. BMC Plant Biol. 2016;16:122 pubmed publisher
    ..expression of miR156 in later fruit developmental may positively regulate anthocyanin biosynthesis by reducing SPL transcription factor. Novel miRNAs showed variation in expression among different tissues...
  3. Pyszko J, Strosznajder J. The key role of sphingosine kinases in the molecular mechanism of neuronal cell survival and death in an experimental model of Parkinson's disease. Folia Neuropathol. 2014;52:260-9 pubmed
    ..Our data indicated that MPP+ (3 mM) induced significant alterations of Sphks and S1P lyase (SPL) gene expression...
  4. Elseweidy M, Askar M, Elswefy S, Shawky M. Nephrotoxicity Induced by Cisplatin Intake in Experimental Rats and Therapeutic Approach of Using Mesenchymal Stem Cells and Spironolactone. Appl Biochem Biotechnol. 2018;184:1390-1403 pubmed publisher
    ..In the last years, many studies have focused on spironolactone (SPL), a mineralocorticoid receptor antagonist, and its pharmacological effects...
  5. Garcia Molina A, Xing S, Huijser P. Functional characterisation of Arabidopsis SPL7 conserved protein domains suggests novel regulatory mechanisms in the Cu deficiency response. BMC Plant Biol. 2014;14:231 pubmed publisher
    The Arabidopsis SQUAMOSA PROMOTER-BINDING PROTEIN-LIKE (SPL) transcription factor SPL7 reprograms cellular gene expression to adapt plant growth and cellular metabolism to copper (Cu) limited culture conditions...
  6. Li S, Li K, Ju Z, Cao D, Fu D, Zhu H, et al. Genome-wide analysis of tomato NF-Y factors and their role in fruit ripening. BMC Genomics. 2016;17:36 pubmed publisher
    ..It is known that various TFs, such as MADS-domain, MYB, AP2/ERF and SBP/SPL family proteins play key roles in modulating ripening...
  7. Carreres Pons M, Chalansonnet M, Venet T, Thomas A, Nunge H, Merlen L, et al. Carbon disulfide potentiates the effects of impulse noise on the organ of Corti. Neurotoxicology. 2017;59:79-87 pubmed publisher
    ..Although the LEX,8h (8-h time-weighted average exposure) for the impulse noise was lower (84dB SPL) than that for the continuous noise (89dB SPL), it appeared more damaging to the organ of Corti, in particular to ..
  8. Sehirli A, Cetinel S, Ozkan N, Selman S, Tetik S, Yuksel M, et al. St. John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis off rats through the induction of pregnane X receptors and/or P-glycoproteins. J Physiol Pharmacol. 2015;66:203-14 pubmed
    ..The goal of this study was to investigate whether St. John's wort (SJW) and spironolactone (SPL), both known to have strong inducing effects on cytochrome P 450 (CYP) enzymes as well as PXR and P-gp, have ..
  9. Abu Khweek A, Kanneganti A, Guttridge D D, Amer A. The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages. PLoS ONE. 2016;11:e0146410 pubmed publisher
    ..It is homologous to the eukaryotic sphingosine lyase (SPL), an enzyme required in the terminal steps of sphingolipid metabolism...
  10. Schwiebs A, Herrero San Juan M, Schmidt K, Wiercinska E, Anlauf M, Ottenlinger F, et al. Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase. Oncogene. 2019;: pubmed publisher
    ..3D organoid cultures were used in vitro. S1P lyase (SGPL1) knockout in either immune cells or tissue, caused local sphingolipid accumulation leading to a dichotomic ..
  11. Huang L, Natarajan V. Sphingolipids in pulmonary fibrosis. Adv Biol Regul. 2015;57:55-63 pubmed publisher
    ..of SphK1, but not SphK2, ameliorated bleomycin-induced pulmonary fibrosis in mice while deletion of S1PL (SGPL1(+/-)) in mice potentiated fibrosis post-bleomycin challenge...
  12. Liu L, Wang F, Lu H, Cao S, Du Z, Wang Y, et al. Effects of Noise Exposure on Systemic and Tissue-Level Markers of Glucose Homeostasis and Insulin Resistance in Male Mice. Environ Health Perspect. 2016;124:1390-8 pubmed publisher
    ..N20D, N10D, and N1D), in which the animals were exposed to white noise at 95 decibel sound pressure level (dB SPL) for 4 hr per day for 20 successive days, 10 successive days, or 1 day, respectively...
  13. Teufelberger A, Nordengrün M, Braun H, Maes T, De Grove K, Holtappels G, et al. The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D. J Allergy Clin Immunol. 2017;: pubmed publisher
    ..Staphylococcus aureus-derived serine protease-like protein (Spl) D and other closely related proteases secreted by S aureus have recently been identified as inducers of allergic ..
  14. Qu L, Qu F, Jia Z, Wang C, Wu C, Zhang J. Integrated targeted sphingolipidomics and transcriptomics reveal abnormal sphingolipid metabolism as a novel mechanism of the hepatotoxicity and nephrotoxicity of triptolide. J Ethnopharmacol. 2015;170:28-38 pubmed publisher
    ..The aim of this study is to understand the regulatory role of sphingolipid (SPL) pathways in the TP-induced toxic mechanism in the liver and kidney in delayed-type hypersensitivity (DTH) Balb\c ..
  15. Garg V, Singh H, Bhatia A, Raza K, Singh S, Singh B, et al. Systematic Development of Transethosomal Gel System of Piroxicam: Formulation Optimization, In Vitro Evaluation, and Ex Vivo Assessment. AAPS PharmSciTech. 2017;18:58-71 pubmed publisher
    ..Among the various lipids used, soya phosphatidylcholine (SPL 70) and ethanol in various percentages were found to affect drug retention in the skin, drug permeation, vesicle ..
  16. Zahnert T, Mlynski R, Löwenheim H, Beutner D, Hagen R, Ernst A, et al. Long-Term Outcomes of Vibroplasty Coupler Implantations to Treat Mixed/Conductive Hearing Loss. Audiol Neurootol. 2018;23:316-325 pubmed publisher
    ..5 ± 11.4 dB HL (12 months) and 38.8 ± 12.5 dB HL (36 months). Mean word recognition scores at 65 dB SPL increased from 2.9% in the unaided by 64.2% to 67.1% in the aided situation...
  17. Busche T, Hillion M, Van Loi V, Berg D, Walther B, Semmler T, et al. Comparative Secretome Analyses of Human and Zoonotic Staphylococcus aureus Isolates CC8, CC22, and CC398. Mol Cell Proteomics. 2018;17:2412-2433 pubmed publisher
    ..Overall, comparative secretome analyses revealed CC8- or CC22-specific enterotoxin and Spl protease secretion as well as Agr- and SigB-controlled differences in exotoxin and surface protein secretion ..
  18. Flück C. MECHANISMS IN ENDOCRINOLOGY: Update on pathogenesis of primary adrenal insufficiency: beyond steroid enzyme deficiency and autoimmune adrenal destruction. Eur J Endocrinol. 2017;177:R99-R111 pubmed publisher
    ..nephrotic syndrome and ichthyosis caused by mutations in the gene for sphingosine-1-phosphate lyase 1 (SGPL1). This review intends do give an update on novel genetic forms of PAI and their suggested mechanism of disease...
  19. Han Y, Ma Y, Li D, Yao J, Xu Z. Characterization and phylogenetic analysis of fifteen NtabSPL genes in Nicotiana tabacum L. cv. Qinyan95. Dev Genes Evol. 2016;226:1-14 pubmed publisher
    Fifteen SPL (SQUAMOSA PROMOTER BINDING PROTEIN-LIKE) genes were identified and characterized in Nicotiana tabacum L. cv. Qinyan95...
  20. Xiao Y, Chen X, Shi H, Yang Y, He L, Dong J, et al. Evaluation of airway obstruction at soft palate level in male patients with obstructive sleep apnea/hypopnea syndrome: dynamic 3-dimensional CT imaging of upper airway. J Huazhong Univ Sci Technolog Med Sci. 2011;31:413 pubmed publisher
    ..The soft palate length (SPL), the minimal cross-sectional area of the retropalatal region (mXSA-RP), and the vertical distance from the hard ..
  21. Gao R, Austin R, Amyot L, Hannoufa A. Comparative transcriptome investigation of global gene expression changes caused by miR156 overexpression in Medicago sativa. BMC Genomics. 2016;17:658 pubmed publisher
    ..Transcripts of three SQUAMOSA-PROMOTER BINDING PROTEIN-LIKE (SPL) genes (MsSPL6, MsSPL12, and MsSPL13) were found to be targeted for cleavage by MsmiR156 in alfalfa...
  22. Bulut E, Uzun C, Ozturk L, Turan P, Kanter M, Arbak S. A New Hypothesis on the Frequency Discrimination of the Cochlea. J Int Adv Otol. 2017;13:204-210 pubmed publisher
    ..recordings with or without contralateral pure-tone acoustic stimuli (1 and 8 kHz) at 60 dB sound pressure level (SPL)...
  23. Shukla M, Roy K, Kaur C, Nayak D, Mani K, Shukla S, et al. Attenuation of adverse effects of noise induced hearing loss on adult neurogenesis and memory in rats by intervention with Adenosine A2A receptor agonist. Brain Res Bull. 2019;147:47-57 pubmed publisher
    ..Dawley rats weighing 200-250 g m were randomly allocated into three groups: Group 1) rats exposed to 100 dB SPL white noise, 2 h a day for 15 consecutive days, 2) rats supplemented with an adenosine receptor agonist, CGS21680 ..
  24. Wen J, Duan N, Wang Q, Jing G, Xiao Y. Protective effect of propofol on noise-induced hearing loss. Brain Res. 2017;1657:95-100 pubmed publisher
    ..For noise exposure, an octave band noise at a 124dB sound pressure level (SPL) was administered to animals for 2h. The mean arterial pressure (MAP) and CoBF were monitored continuously...
  25. Djouiai B, Thwaite J, Laws T, Commichau F, Setlow B, Setlow P, et al. Role of DNA Repair and Protective Components in Bacillus subtilis Spore Resistance to Inactivation by 400-nm-Wavelength Blue Light. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..and BER), translesion synthesis (TLS) by Y-family DNA polymerases, and spore photoproduct (SP) removal by SP lyase (SPL)...
  26. Citterio C, Morales C, Bouhours Nouet N, Machiavelli G, Bueno E, Gatelais F, et al. Novel compound heterozygous Thyroglobulin mutations c.745+1G>A/c.7036+2T>A associated with congenital goiter and hypothyroidism in a Vietnamese family. Identification of a new cryptic 5' splice site in the exon 6. Mol Cell Endocrinol. 2015;404:102-12 pubmed publisher
    ..The theoretical consequences of splice site mutations, predicted with the bioinformatics tool NNSplice, Fsplice, SPL, SPLM and MaxEntScan programs were investigated and evaluated in relation with the experimental evidence...
  27. Zeh R, Baumann U. [Inpatient rehabilitation of adult CI users: Results in dependency of duration of deafness, CI experience and age]. HNO. 2015;63:557-76 pubmed publisher
    ..of vowel/consonant identification, the Freiburg numbers and monosyllabic test (65 and 80 dB sound pressure level, SPL, free-field sound level), the Hochmair-Schulz-Moser (HSM) sentence test in quiet and in noise (65 dB SPL speech ..
  28. Vlajkovic S, Ambepitiya K, Barclay M, Boison D, Housley G, Thorne P. Adenosine receptors regulate susceptibility to noise-induced neural injury in the mouse cochlea and hearing loss. Hear Res. 2017;345:43-51 pubmed publisher
    ..Wildtype (WT) and AR deficient mice were exposed to octave band noise (8-16 kHz, 100 dB SPL) for 2 h to induce cochlear injury and hearing loss...
  29. Milon B, Mitra S, Song Y, Margulies Z, Casserly R, Drake V, et al. The impact of biological sex on the response to noise and otoprotective therapies against acoustic injury in mice. Biol Sex Differ. 2018;9:12 pubmed publisher
    ..the hearing of 10-week-old B6CBAF1/J mice of both sexes, which were exposed to 2 h of octave-band noise (101 dB SPL centered at 11.3 kHz)...
  30. Ostria Gallardo E, Ranjan A, Chitwood D, Kumar R, Townsley B, Ichihashi Y, et al. Transcriptomic analysis suggests a key role for SQUAMOSA PROMOTER BINDING PROTEIN LIKE, NAC and YUCCA genes in the heteroblastic development of the temperate rainforest tree Gevuina avellana (Proteaceae). New Phytol. 2016;210:694-708 pubmed publisher
    ..We found a steady up-regulation of SQUAMOSA PROMOTER BINDING PROTEIN LIKE (SPL), NAC, YUCCA and AGAMOUS-LIKE genes associated with increases in age, leaf complexity, and light availability...
  31. Aithal V, Kei J, Driscoll C, Murakoshi M, Wada H. Effects of ear canal static pressure on the dynamic behaviour of outer and middle ear in newborns. Int J Pediatr Otorhinolaryngol. 2016;82:64-72 pubmed publisher
    ..applied to the ear canal was varied from 200 to -200daPa, was evaluated in terms of the sound pressure level (SPL) in the ear canal, resonance frequency (RF) and displacement (ΔSPL)...
  32. Okasha H, Elkholy S, El Sayed R, Wifi M, El Nady M, El Nabawi W, et al. Real time endoscopic ultrasound elastography and strain ratio in the diagnosis of solid pancreatic lesions. World J Gastroenterol. 2017;23:5962-5968 pubmed publisher
    ..the accuracy of the elastography score combined to the strain ratio in the diagnosis of solid pancreatic lesions (SPL)...
  33. Wang J, Tian Y, Wang M, Cao L, Wu H, Zhang Y, et al. A lateralized top-down network for visuospatial attention and neglect. Brain Imaging Behav. 2016;10:1029-1037 pubmed
    ..were closely related to the bias of top-down functional connectivity between posterior superior parietal lobule (SPL) and V1...
  34. Zhou B, Fan P, Li Y, Yan H, Xu Q. Exploring miRNAs involved in blue/UV-A light response in Brassica rapa reveals special regulatory mode during seedling development. BMC Plant Biol. 2016;16:111 pubmed publisher
    ..and BrmiR157 were present in the greatest amount (number of reads) and among their 8 putative targets in the SPL gene family, only SPL9 (Bra004674) and SPL15 (Bra003305) increased in expression after blue or UV-A exposure...
  35. Harijith A, Pendyala S, Ebenezer D, Ha A, Fu P, Wang Y, et al. Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium. Am J Physiol Lung Cell Mol Physiol. 2016;311:L337-51 pubmed publisher
    ..S1P is metabolized predominantly by S1P lyase and partial deletion of Sgpl1 (Sgpl1(+/-)) in mice accentuated lung injury...
  36. Asp F, Olofsson Ã, Berninger E. Corneal-Reflection Eye-Tracking Technique for the Assessment of Horizontal Sound Localization Accuracy from 6 Months of Age. Ear Hear. 2016;37:e104-18 pubmed publisher
    ..An ongoing auditory-visual stimulus was presented at 63 dB SPL(A) and shifted to randomized loudspeakers simultaneously with pauses of the visual stimulus...
  37. D Alessandro L, Harrison R. Midbrain Frequency Representation following Moderately Intense Neonatal Sound Exposure in a Precocious Animal Model (Chinchilla laniger). Neural Plast. 2016;2016:3734646 pubmed
    ..Neonatal chinchillas were chronically exposed to a 2?kHz narrowband sound at 70?dB?SPL for 4 weeks...
  38. Mosnier I, Mathias N, Flament J, Amar D, Liagre Callies A, Borel S, et al. Benefit of the UltraZoom beamforming technology in noise in cochlear implant users. Eur Arch Otorhinolaryngol. 2017;274:3335-3342 pubmed publisher
    ..The noise was presented at a fixed level of 65 dB SPL and the level of speech signal was varied to obtain the speech reception threshold (SRT)...
  39. Wang X, Luo G, Yang W, Li Y, Sun J, Zhan K, et al. Genetic diversity, population structure and marker-trait associations for agronomic and grain traits in wild diploid wheat Triticum urartu. BMC Plant Biol. 2017;17:112 pubmed publisher
    ..sequence repeats (SSR) or HMW-GSs and six morphological traits: heading date (HD), plant height (PH), spike length (SPL), spikelet number per spike (SPLN), tiller angle (TA) and grain length (GL)...
  40. Bamborschke D, Pergande M, Becker K, Koerber F, Dotsch J, Vierzig A, et al. A novel mutation in sphingosine-1-phosphate lyase causing congenital brain malformation. Brain Dev. 2018;40:480-483 pubmed publisher
    Recently recessive mutations in sphingosine-1-phosphate lyase (SGPL1) have been published as a cause of syndromic congenital nephrotic syndrome with adrenal insufficiency...
  41. Rantala L, Hakala S, Holmqvist S, Sala E. Classroom Noise and Teachers' Voice Production. J Speech Lang Hear Res. 2015;58:1397-406 pubmed publisher
    ..Voice variables measured were sound pressure level (voice SPL), fundamental frequency, jitter, shimmer, and the tilt of the sound spectrum slope (alpha ratio)...
  42. Schormans A, Typlt M, Allman B. Crossmodal plasticity in auditory, visual and multisensory cortical areas following noise-induced hearing loss in adulthood. Hear Res. 2017;343:92-107 pubmed publisher
    ..8-20 kHz at 120 dB SPL for 2 h) and age-matched controls to characterize the nature and extent of crossmodal plasticity in the dorsal ..
  43. Schmidt T, Baljic I. [Examination of a training effect in the Freiburg monosyllabic test]. HNO. 2016;64:584-8 pubmed publisher
    ..According to DIN 45626-1, the 50?% speech discrimination score is expected at a level of 29.3 dB SPL (Sound Pressure Level). In this study, the test material was presented at a level of 29 dB SPL...
  44. Park S, Chung J, Kang D, Ryu D, Cho W, Lee S. The Change of Stretched Penile Length and Anthropometric Data in Korean Children Aged 0-14 Years: Comparative Study of Last 25 Years. J Korean Med Sci. 2016;31:1631-4 pubmed publisher
    ..The stretched penile length (SPL) was measured and the testicular size was measured using orchidometry (mL)...
  45. Bottalico P. Speech Adjustments for Room Acoustics and Their Effects on Vocal Effort. J Voice. 2017;31:392.e1-392.e12 pubmed publisher
    ..The results provide insight into how voice acoustical parameters can predict vocal effort. In particular, it increased when SPL and f0 increased and when the amplitude voice modulation decreased.
  46. Hirose T, Tanaka Y, Tanaka A, Sakai H, Sasaki Y, Shinohara N, et al. PD-L1/PD-L2-expressing B-1 cells inhibit alloreactive T cells in mice. PLoS ONE. 2017;12:e0178765 pubmed publisher
    ..prolonged the survival of subsequently grafted Balb/c hearts in B6 mouse recipients, whereas that with SPL B cells did not...
  47. Milekhina O, Nechaev D, Supin A. Compressive nonlinearity of human hearing in sound spectra discrimination. Dokl Biol Sci. 2017;474:89-92 pubmed publisher
    ..increased proportionally to the signal at signal intensity levels below 50 dB, whereas at signal levels above 60 dB SPL, the ratio of the masker level at threshold gradient to signal level gradient was 1 : 5 dB/dB, revealing cochlear ..
  48. Du L, Qi S, Ma J, Xing L, Fan S, Zhang S, et al. Identification of TPS family members in apple (Malus x domestica Borkh.) and the effect of sucrose sprays on TPS expression and floral induction. Plant Physiol Biochem. 2017;120:10-23 pubmed publisher
    ..In addition, the expression levels of flowering-related genes (e.g., SPL genes, FT1, and AP1) also increased in response to the sucrose sprays...
  49. Kok A, Engelberts J, Kastelein R, Helder Hoek L, Van de Voorde S, Visser F, et al. Spatial avoidance to experimental increase of intermittent and continuous sound in two captive harbour porpoises. Environ Pollut. 2018;233:1024-1036 pubmed publisher
    ..The combination of temporal structure and SPL caused variable patterns. When the sound was intermittent, increased SPL caused increased avoidance times...
  50. Gamberini M, Dal Bò G, Breveglieri R, Briganti S, Passarelli L, Fattori P, et al. Sensory properties of the caudal aspect of the macaque's superior parietal lobule. Brain Struct Funct. 2018;223:1863-1879 pubmed publisher
    In the superior parietal lobule (SPL), the anterior part (area PE) is known to process somatosensory information, while the caudalmost part (areas V6Av and V6) processes visual information...
  51. Djinović Z, Pavelka R, Tomic M, Sprinzl G, Plenk H, Losert U, et al. In-vitro and in-vivo measurement of the animal's middle ear acoustical response by partially implantable fiber-optic sensing system. Biosens Bioelectron. 2018;103:176-181 pubmed publisher
    ..incus was measured while a cadaver and living sheep was exposed to the sinusoidal acoustical excitation of 40-90dB SPL, in the frequency range from 100Hz to 10kHz...
  52. Scheifele P, Johnson M, Byrne D, Clark J, Vandlik A, Kretschmer L, et al. Noise impacts from professional dog grooming forced-air dryers. Noise Health. 2012;14:224-6 pubmed publisher
    ..5 to 108.3 db spl or 94.8 to 108.0 dba...
  53. Lau C, Pienkowski M, Zhang J, McPherson B, Wu E. Chronic exposure to broadband noise at moderate sound pressure levels spatially shifts tone-evoked responses in the rat auditory midbrain. Neuroimage. 2015;122:44-51 pubmed publisher
    ..High SPL exposures occur in occupational and recreational settings and affect a substantial proportion of the population...
  54. Bi F, Meng X, Ma C, Yi G. Identification of miRNAs involved in fruit ripening in Cavendish bananas by deep sequencing. BMC Genomics. 2015;16:776 pubmed publisher
    ..The miRNA target genes encode transcription factors and other functional proteins, including SPL, APETALA2, EIN3, E3 ubiquitin ligase, β-galactosidase, and β-glucosidase...
  55. Dudzinski K, Melillo Sweeting K, Gregg J. Documenting and Assessing Dolphin Calls and Ambient and Anthropogenic Noise Levels via PAM and a SPL Meter. Adv Exp Med Biol. 2016;875:245-53 pubmed publisher
    ..These data were compared with values from a custom-built sound pressure level (SPL) meter and confirm that the SM2M recorder is a useful tool for assessing animal calls and ambient and anthropogenic ..
  56. Fascelli M, Rais Bahrami S, Sankineni S, Brown A, George A, Ho R, et al. Combined Biparametric Prostate Magnetic Resonance Imaging and Prostate-specific Antigen in the Detection of Prostate Cancer: A Validation Study in a Biopsy-naive Patient Population. Urology. 2016;88:125-34 pubmed publisher
    ..Previously reported composite formulas incorporating screen positive lesions (SPL) on B-MRI and PSA or PSAD were developed to maximize PCa detection...
  57. Chang M, Han S, Shin H, Byun J, Rah Y, Park M. Protective effect of a purified polyphenolic extract from Ecklonia cava against noise-induced hearing loss: Prevention of temporary threshold shift. Int J Pediatr Otorhinolaryngol. 2016;87:178-84 pubmed publisher
    ..intraperitoneal PPEE (100 mg/kg) and saline, respectively, for 5 days before exposure to noise at 100 dB SPL for 60 min...
  58. Dewey J, Dhar S. Profiles of Stimulus-Frequency Otoacoustic Emissions from 0.5 to 20 kHz in Humans. J Assoc Res Otolaryngol. 2017;18:89-110 pubmed publisher
    ..audiogram (?12-15 kHz), though their amplitudes often declined substantially above ?7 kHz, rarely exceeding 0 dB SPL above 8 kHz...
  59. Li J, Wu C, Zheng Y, Li R, Li X, She S, et al. Schizophrenia affects speech-induced functional connectivity of the superior temporal gyrus under cocktail-party listening conditions. Neuroscience. 2017;359:248-257 pubmed publisher
    ..participants, participants with schizophrenia showed declined FC of the STG with the bilateral precuneus, right SPL, and right supplementary motor area...
  60. Berdyshev E, Gorshkova I, Usatyuk P, Kalari S, Zhao Y, Pyne N, et al. Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase. PLoS ONE. 2011;6:e16571 pubmed publisher
    ..cells generate intracellular S1P, here we have investigated the role of sphingosine kinases (SphKs) and S1P lyase (S1PL), that regulate intracellular S1P accumulation, in HPAEC motility...
  61. Ihlefeld K, Vienken H, Claas R, Blankenbach K, Rudowski A, Ter Braak M, et al. Upregulation of ABC transporters contributes to chemoresistance of sphingosine 1-phosphate lyase-deficient fibroblasts. J Lipid Res. 2015;56:60-9 pubmed publisher
    ..It has been reported previously that embryonic fibroblasts from S1P lyase-deficient mice (Sgpl1(-/-)-MEFs) are resistant to chemotherapy-induced apoptosis through upregulation of B cell lymphoma 2 (Bcl-2) and ..
  62. Jeong Y, Hong J. Governing effect of regulatory proteins for Cl(-)/HCO3(-) exchanger 2 activity. Channels (Austin). 2016;10:214-24 pubmed publisher
    ..We found that SPL binds to AE2 and markedly increased the Cl(-)/HCO3(-) exchange activity of AE2. Especially SPL 1-480 domain is required for enhancing AE2 activity...
  63. TerzioÄŸlu F, Yücel Ã, Koç G, ÅžimÅŸek Å, YaÅŸar B, Åžahan F, et al. A new strategy in nursing education: From hybrid simulation to clinical practice. Nurse Educ Today. 2016;39:104-8 pubmed publisher
    ..under the supervision of a faculty member in the nursing skills laboratory (NSL), standardized patient laboratory (SPL) and clinical practice environment (CPE) respectively...
  64. Amoako Tuffour Y, Garland P, Bance M. Interpretation of sonotubometric data based on phase-shift detection. J Otolaryngol Head Neck Surg. 2016;45:37 pubmed publisher
    ..in sonotubometric signals would be a more reliable indicator of ET patency than fluctuating Sound Pressure Level (SPL)...
  65. Jeanson L, Wiegrebe L, Gurkov R, Krause E, Drexl M. Aftereffects of Intense Low-Frequency Sound on Spontaneous Otoacoustic Emissions: Effect of Frequency and Level. J Assoc Res Otolaryngol. 2017;18:111-119 pubmed publisher
    ..Trials were carried out with several LF sound levels (93 to 108 dB SPL corresponding to 47 to 75 phons at a fixed frequency of 30 Hz) and different LF sound frequencies (30, 60, 120, ..
  66. Murphy W, Flamme G, Meinke D, Sondergaard J, Finan D, Lankford J, et al. Measurement of impulse peak insertion loss for four hearing protection devices in field conditions. Int J Audiol. 2012;51 Suppl 1:S31-42 pubmed publisher
    ..method utilizes an acoustic test fixture and three ranges for impulse levels: 130-134, 148-152, and 166-170 dB peak SPL. For this study, four different models of hearing protectors were tested: Bilsom 707 Impact II electronic earmuff, ..
  67. Cheng L, Wang S, Huang Y, Liao X. The hippocampus may be more susceptible to environmental noise than the auditory cortex. Hear Res. 2016;333:93-97 pubmed publisher
    ..The AC and hippocampus of mice were separated following 1 or 3 weeks exposure to moderate noise (80 dB SPL, 2 h/day)...
  68. Moore B, Baer T, Ives D, Marriage J, Salorio Corbetto M. Effects of Modified Hearing Aid Fittings on Loudness and Tone Quality for Different Acoustic Scenes. Ear Hear. 2016;37:483-91 pubmed publisher
    ..For normal-hearing participants, levels of 50, 65, and 80 dB SPL were used...
  69. Surya S, Abhilash J, Geethanandan K, Sadasivan C, Haridas M. A profile of protein-protein interaction: Crystal structure of a lectin-lectin complex. Int J Biol Macromol. 2016;87:529-36 pubmed publisher
    ..the association of two galactose-specific legume lectins from Butea monosperma (BML) and Spatholobus parviflorus (SPL) belonging to Fabaceae family helped to compute the binding equilibrium...
  70. Baspinar S, Kirnap M, Baspinar O, Dizdar O, Kocer D. Serum prolidase level in ankylosing spondylitis: low serum levels as a new potential gold standard biomarker for disease activity. Rheumatol Int. 2016;36:1609-1616 pubmed
    ..The aim of this study was to assess serum prolidase level (SPL) and its association with disease activity in patients with AS. This prospective study included 75 AS patients...
  71. Cheng L, Wang S, Peng K, Liao X. Long-Term Impairment of Sound Processing in the Auditory Midbrain by Daily Short-Term Exposure to Moderate Noise. Neural Plast. 2017;2017:3026749 pubmed publisher
    ..properties of auditory midbrain neurons were recorded in anesthetized mice exposed to moderate noise (80 dB SPL, 2 h/d for 6 weeks) and were compared with those from age-matched controls...
  72. Shao F, Lu Q, Wilson I, Qiu D. Genome-wide identification and characterization of the SPL gene family in Ziziphus jujuba. Gene. 2017;627:315-321 pubmed publisher
    ..The SPL gene family has been studied in various plant species; however, there is no report about SPLs in Zizyphus jujuba...
  73. Meyer Zum Gottesberge A, Massing T, Sasse A, Palma S, Hansen S. Zucker diabetic fatty rats, a model for type 2 diabetes, develop an inner ear dysfunction that can be attenuated by losartan treatment. Cell Tissue Res. 2015;362:307-15 pubmed publisher
    ..0 ± 2.1 dB SPL) compared to both non-diabetic controls (34...
  74. Ghoncheh M, Lilli G, Lenarz T, Maier H. Outer ear canal sound pressure and bone vibration measurement in SSD and CHL patients using a transcutaneous bone conduction instrument. Hear Res. 2016;340:161-168 pubmed publisher
    ..to measure vibration of the bone close to the implant to Outer Ear Canal Sound Pressure Level (OEC-SPL) measurements...
  75. Santos T, Silva J, Lins O, Melges D, Tierra Criollo C. Detection efficiency of auditory steady state evoked by modulated noise. Hear Res. 2016;339:125-31 pubmed publisher
    ..noise (TBN) between 77 and 110 Hz, applied in intensity levels of 55, 45, and 25 dB sound pressure level (SPL). MSC and SFT, two statistical-based detection techniques, were applied with a significance level of 5%...
  76. Zhao F, Zheng Y, Zeng T, Sun R, Yang J, Li Y, et al. Phosphorylation of SPOROCYTELESS/NOZZLE by the MPK3/6 Kinase Is Required for Anther Development. Plant Physiol. 2017;173:2265-2277 pubmed publisher
    ..Although SPOROCYTELESS (SPL) transcription is activated by the floral organ identity regulator AGAMOUS and epigenetically regulated by SET ..
  77. Chou M, Hsieh Y, Huang C, Chen P, Chan S, Tsao Y, et al. BCAS2 Regulates Delta-Notch Signaling Activity through Delta Pre-mRNA Splicing in Drosophila Wing Development. PLoS ONE. 2015;10:e0130706 pubmed publisher
    ..of Delta pre-mRNA, resulting in diminished transcriptions of Delta-Notch signaling target genes, such as cut and E(spl)m8...
  78. Eriksson T, Laws M, Kang L, Fan Y, Ramadas S, Dixon S. Experimental Evaluation of Three Designs of Electrodynamic Flexural Transducers. Sensors (Basel). 2016;16: pubmed publisher
    ..All three designs produced large acoustic pressure outputs, with a recorded sound pressure level (SPL) above 120 dB at a 40 cm distance from the highest output transducer...
  79. Burnham J, Yonz M, Robertson K, McKinley R, Wilson B, Johnson D, et al. Relationship of Hip and Trunk Muscle Function with Single Leg Step-Down Performance: Implications for Return to Play Screening and Rehabilitation. Phys Ther Sport. 2016;22:66-73 pubmed publisher
    ..Trunk endurance was measured with plank (PL) and side plank (SPL) tests. SLSD repetitions in 60-s and dynamic knee valgus (VAL) were recorded...
  80. Jia X, Chen Y, Xu X, Shen F, Zheng Q, Du Z, et al. miR156 switches on vegetative phase change under the regulation of redox signals in apple seedlings. Sci Rep. 2017;7:14223 pubmed publisher
    In higher plants, miR156 regulates the vegetative phase change via the target SBP/SPL genes. The regulation of miR156 during ontogenetic processes is not fully understood...
  81. Chantarojanasiri T, Kongkam P. Endoscopic ultrasound elastography for solid pancreatic lesions. World J Gastrointest Endosc. 2017;9:506-513 pubmed publisher
    Elastography is one of technologies assisting diagnosis of solid pancreatic lesions (SPL)...
  82. Morgan A, Turic D, Jehu L, Hamilton G, Hollingworth P, Moskvina V, et al. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:762-70 pubmed
    ..10 (APBB1IP, ALOX5, AD037, SLC18A3, DKK1, ZWINT, ANK3, UBE2D1, CDC2, SIRT1, JDP1, NET7, SUPV3L1, NEN3, SAR1, SGPL1, SEC24C, CAMK2G, PP3CB, SNCG, CH25H, PLCE1, ANXV111) in the MRC genetic resource for LOAD...
  83. Mezzar S, De Schryver E, Van Veldhoven P. RP-HPLC-fluorescence analysis of aliphatic aldehydes: application to aldehyde-generating enzymes HACL1 and SGPL1. J Lipid Res. 2014;55:573-82 pubmed publisher
    ..steps of these processes are 2-hydroxyacyl-CoA lyase (HACL1) and sphingosine-1-phosphate lyase (SGPL1), respectively...
  84. Lin L, Wang K, Meng D, Zuo W, Zhang L. Active Self-Paced Learning for Cost-Effective and Progressive Face Identification. IEEE Trans Pattern Anal Mach Intell. 2018;40:7-19 pubmed publisher
    ..By naturally combining two recently rising techniques: active learning (AL) and self-paced learning (SPL), our framework is capable of automatically annotating new instances and incorporating them into training under ..
  85. Dobrosak C, Gooi J. Increased sphingosine-1-phosphate production in response to osteocyte mechanotransduction. Bone Rep. 2017;7:114-120 pubmed publisher
    ..Exposure to mechanical loading resulted in a downregulation in Sost, Spns2, the S1P transporter, Sgpl1 and Sgppl1 the enzymes responsible for degradation and dephosphorylation of S1P...
  86. Rawlings C, Zientek M, Spieser M, Urbonas D, Stöferle T, Mahrt R, et al. Control of the interaction strength of photonic molecules by nanometer precise 3D fabrication. Sci Rep. 2017;7:16502 pubmed publisher
    ..Here we present a complete patterning and pattern-transfer solution based on thermal scanning probe lithography (t-SPL) and dry etching...
  87. Lovric S, Gonçalves S, Gee H, Oskouian B, Srinivas H, Choi W, et al. Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. J Clin Invest. 2017;127:912-928 pubmed publisher
    ..insufficiency, immunodeficiency, and neurological defects, we identified 9 different recessive mutations in SGPL1, which encodes sphingosine-1-phosphate (S1P) lyase...
  88. Lum K, Sato Y, Beyer B, Plaisted W, Anglin J, Lairson L, et al. Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017;12:2671-2681 pubmed publisher
    ..antifungal drug that attenuates disease severity in preclinical models of multiple sclerosis-inhibits SGPL1, an enzyme that degrades the signaling lipid sphingosine-1-phosphate, drug analogues of which are used to treat ..
  89. Polechoński J, Nawrocka A, Juras G, Błaszczyk J. Evaluation of startle response and prepulse inhibition based on changes in the range of vertical pressure force of the feet on the ground: a preliminary study. Neurol Sci. 2017;38:2139-2143 pubmed publisher
    ..It was triggered by a strong acoustic stimulus (106 dB SPL, 40 ms), which was preceded by a similar, weaker signal (80 dB SPL, 20 ms)...
  90. Adamiak M, Chelvarajan L, Lynch K, Santos W, Abdel Latif A, Ratajczak M. Mobilization studies in mice deficient in sphingosine kinase 2 support a crucial role of the plasma level of sphingosine-1-phosphate in the egress of hematopoietic stem progenitor cells. Oncotarget. 2017;8:65588-65600 pubmed publisher
    ..S1P gradients in blood plasma in the mobilization process and indicate that small-molecule inhibitors of Sphk2 and Sgpl1 could be employed as mobilization-facilitating compounds...
  91. Uranbileg B, Nishikawa T, Ikeda H, Kurano M, Sato M, Saigusa D, et al. Evidence Suggests Sphingosine 1-Phosphate Might Be Actively Generated, Degraded, and Transported to Extracellular Spaces With Increased S1P2 and S1P3 Expression in Colon Cancer. Clin Colorectal Cancer. 2018;17:e171-e182 pubmed publisher
    ..Upregulation of S1P-generating sphingosine kinases (SKs) and downregulation of S1P-degrading S1P lyase (SPL) might increase intracellular S1P levels to exert a prosurvival effect in cancer in general, such as colon cancer...
  92. Gatfield J, Monnier L, Studer R, Bolli M, Steiner B, Nayler O. Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling. Cell Signal. 2014;26:1576-88 pubmed publisher
    ..This suggests that S1P lyase - by facilitating S1P1 receptor recycling - is essential for S1P-mediated sustained signaling, and that synthetic agonists are functional antagonists because they are not S1P lyase substrates. ..