SGK3

Summary

Gene Symbol: SGK3
Description: serum/glucocorticoid regulated kinase family member 3
Alias: CISK, SGK2, SGKL, serine/threonine-protein kinase Sgk3, cytokine-independent survival kinase
Species: human
Products:     SGK3

Top Publications

  1. Bruhn M, Pearson R, Hannan R, Sheppard K. Second AKT: the rise of SGK in cancer signalling. Growth Factors. 2010;28:394-408 pubmed publisher
    ..Recent evidence suggests that mutant PI3Kinase can induce tumorigenesis through an AKT-independent but SGK3-dependent mechanism, thus implicating SGKs as potential players in malignant transformation...
  2. Wang Y, Zhou D, Phung S, Masri S, Smith D, Chen S. SGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cells. Mol Endocrinol. 2011;25:72-82 pubmed publisher
    Serum- and glucocorticoid-inducible kinase 3 (SGK3) is a protein kinase of the AGC family of protein kinase A, protein kinase G, and protein kinase C and functions downstream of phosphatidylinositol 3-kinase (PI3K)...
  3. Xu J, Wan M, He Q, Bassett R, Fu X, Chen A, et al. SGK3 is associated with estrogen receptor expression in breast cancer. Breast Cancer Res Treat. 2012;134:531-41 pubmed publisher
    ..In this report, we describe our studies of SGK3's role in breast cancer. SGK3 (also known as CISK) is a member of the AGC family of kinases...
  4. Kobayashi T, Deak M, Morrice N, Cohen P. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. Biochem J. 1999;344 Pt 1:189-97 pubmed
    ..Here we identify two novel isoforms of SGK, termed SGK2 and SGK3, whose catalytic domains share 80% amino acid sequence identity with each other and with SGK (renamed SGK1)...
  5. Hytönen M, Lohi H. A frameshift insertion in SGK3 leads to recessive hairlessness in Scottish Deerhounds: a candidate gene for human alopecia conditions. Hum Genet. 2019;: pubmed publisher
    ..The previous studies have implicated variants in FOXI3 and SGK3 in hairlessness; however, the known variants do not explain hairlessness in all breeds such as SDs...
  6. Cao H, Xu Z, Wang J, Cigliano A, Pilo M, Ribback S, et al. Functional role of SGK3 in PI3K/Pten driven liver tumor development. BMC Cancer. 2019;19:343 pubmed publisher
    ..Serum and glucocorticoid kinase 3 (SGK3) belongs to the SGK family of AGK kinases and functions in parallel to AKT downstream of PI3K...
  7. Zhang H, Nan W, Wang S, Zhang T, Si H, Yang F, et al. Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling. Cell Physiol Biochem. 2016;39:360-70 pubmed publisher
    ..In addition, a number of follicle-regulatory genes, such as Survivin, Msx2 and SGK3, were upregulated by EGF in the ORS cells, which was also inhibited by XAV-939...
  8. Wang H, Zhang J, You G. The mechanistic links between insulin and human organic anion transporter 4. Int J Pharm. 2019;555:165-174 pubmed publisher
    ..Interestingly, in cells overexpressing sgk2, the stimulatory effect of insulin on hOAT4 was diminished...
  9. Yao L, McCormick J, Wang J, Yang K, Kidwai A, Colussi G, et al. Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice. Mol Endocrinol. 2011;25:2106-18 pubmed publisher
    ..The related phosphatidylinositol-3-kinase-dependent kinase, serum- and glucocorticoid-regulated kinase 3 (SGK3), is essential for normal postnatal hair follicle development but plays no apparent role in glucose homeostasis...

More Information

Publications80

  1. Caballero Solares A, Xue X, Parrish C, Foroutani M, Taylor R, Rise M. Changes in the liver transcriptome of farmed Atlantic salmon (Salmo salar) fed experimental diets based on terrestrial alternatives to fish meal and fish oil. BMC Genomics. 2018;19:796 pubmed publisher
    ..the transcription of genes involved in carbohydrate metabolism (gck and pfkfb4), cell growth and proliferation (sgk2 and htra1), apoptosis (gadd45b), lipid metabolism (fabp3, idi1, sqs), and immunity (igd, mx, ifit5, and mhcI)...
  2. Yuan Y, Zhao H, Peng L, Li Z, Liu S, Yuan C, et al. The SGK3-triggered ubiquitin-proteasome degradation of podocalyxin (PC) and ezrin in podocytes was associated with the stability of the PC/ezrin complex. Cell Death Dis. 2018;9:1114 pubmed publisher
    ..Serum- and glucocorticoid-inducible kinase 3 (SGK3) plays a role in the maintenance of podocyte function, but the details of this role are poorly understood...
  3. Talarico C, Dattilo V, D Antona L, Menniti M, Bianco C, Ortuso F, et al. SGK1, the New Player in the Game of Resistance: Chemo-Radio Molecular Target and Strategy for Inhibition. Cell Physiol Biochem. 2016;39:1863-1876 pubmed
    The serum- and glucocorticoid-regulated kinase (SGK) family consists of three members, SGK1, SGK2 and SGK3, all displaying serine/threonine kinase activity and sharing structural and functional similarities with the AKT family of kinases...
  4. Bakre A, Andersen L, Meliopoulos V, Coleman K, Yan X, Brooks P, et al. Identification of Host Kinase Genes Required for Influenza Virus Replication and the Regulatory Role of MicroRNAs. PLoS ONE. 2013;8:e66796 pubmed publisher
    ..From the screen, 17 HPKs (NPR2, MAP3K1, DYRK3, EPHA6, TPK1, PDK2, EXOSC10, NEK8, PLK4, SGK3, NEK3, PANK4, ITPKB, CDC2L5 (CDK13), CALM2, PKN3, and HK2) were validated as essential for A/WSN/33 influenza virus ..
  5. Bhandaru M, Kempe D, Rotte A, Capuano P, Pathare G, Sopjani M, et al. Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3. Kidney Int. 2011;80:61-7 pubmed publisher
    ..pathway, leading to stimulation of several kinases including serum- and glucocorticoid-inducible kinase isoform SGK3, a transport regulating kinase...
  6. Zhang D, Gu D, He J, Hixson J, Rao D, Li C, et al. Associations of the Serum/Glucocorticoid Regulated Kinase Genes With BP Changes and Hypertension Incidence: The Gensalt Study. Am J Hypertens. 2017;30:95-101 pubmed
    ..4×10-3). No evidence for the SGK2 and SGK3 genes was found...
  7. Rodgers S, Ferguson D, Mitchell C, Ooms L. Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases. Biosci Rep. 2017;37: pubmed publisher
    ..for maximal AKT activation and PtdIns3P activates PI3K-dependent serum and glucocorticoid-regulated kinase (SGK3) signalling...
  8. Guo S, Chi M, Yang R, Guo X, Zan L, Wang C, et al. INPP4B is an oncogenic regulator in human colon cancer. Oncogene. 2016;35:3049-61 pubmed publisher
    ..Here we show that silencing of INPP4B blocks activation of Akt and serum- and glucocorticoid-regulated kinase 3 (SGK3), inhibits colon cancer cell proliferation and retards colon cancer xenograft growth...
  9. Schmid E, Bhandaru M, Nurbaeva M, Yang W, Szteyn K, Russo A, et al. SGK3 regulates Ca(2+) entry and migration of dendritic cells. Cell Physiol Biochem. 2012;30:1423-35 pubmed publisher
    ..Downstream targets of PI3K include serum- and glucocorticoid-inducible kinase isoform SGK3. The present study explored, whether SGK3 participates in the regulation of [Ca(2+)](i) and Ca(2+)-dependent ..
  10. Wang H, Xu D, Toh M, Pao A, You G. Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2. Biochem Pharmacol. 2016;102:120-129 pubmed publisher
    ..In the current study, we examined the regulation of hOAT4 by serum- and glucocorticoid-inducible kinase 2 (sgk2) in the kidney COS-7 cells. We showed that sgk2 stimulated hOAT4 transport activity...
  11. Liu H, Li C, Shen C, Yin F, Wang K, Liu Y, et al. MiR-212-3p inhibits glioblastoma cell proliferation by targeting SGK3. J Neurooncol. 2015;122:431-9 pubmed publisher
    ..was significantly down-regulated and negatively correlated with serum and glucocorticoid-inducible kinase 3 (SGK3) in GBM. Either over-expression of miR-212-3p or silence of SGK3 decreased viability of GBM cells...
  12. Qin Z, Zheng H, Zhou L, Ou Y, Huang B, Yan B, et al. Tsc1 deficiency impairs mammary development in mice by suppression of AKT, nuclear ERα, and cell-cycle-driving proteins. Sci Rep. 2016;6:19587 pubmed publisher
    ..Phosphorylated PDK1 and AKT, nuclear ERα, nuclear IRS-1, SGK3, and cell cycle regulators such as Cyclin D1, Cyclin E, CDK2, CDK4 and their target pRB were all apparently down-..
  13. Gotoh S, Negishi M. Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis. Sci Rep. 2015;5:14076 pubmed publisher
    ..Statins utilize pregnane X receptor (PXR) and serum/glucocorticoid regulated kinase 2 (SGK2) to activate phosphoenolpyruvate carboxykinase 1 (PEPCK1) and glucose-6-phosphatase (G6Pase) genes, thereby ..
  14. Liu J, Zhang G, Lv Y, Zhang X, Ying C, Yang S, et al. SGK2 promotes hepatocellular carcinoma progression and mediates GSK-3?/?-catenin signaling in HCC cells. Tumour Biol. 2017;39:1010428317700408 pubmed publisher
    ..serum/glucocorticoid-regulated kinase (SGK) family of serine/threonine kinases consists of three isoforms, SGK1, SGK2, and SGK3...
  15. Gong G, Wang K, Dai X, Zhou Y, Basnet R, Chen Y, et al. Identification, structure modification, and characterization of potential small-molecule SGK3 inhibitors with novel scaffolds. Acta Pharmacol Sin. 2018;39:1902-1912 pubmed publisher
    ..SGK family consists of three isoforms (SGK1, SGK2, and SGK3), which have high sequence homology in the kinase domain and similar substrate specificity with the AKT ..
  16. Chen Y, Sun Z, Qi M, Wang X, Zhang W, Chen C, et al. INPP4B restrains cell proliferation and metastasis via regulation of the PI3K/AKT/SGK pathway. J Cell Mol Med. 2018;22:2935-2943 pubmed publisher
    ..INPP4B reduced the expression of some essential proteins in the PI3K/AKT/SGK3 pathway including p-AKT, p-SGK3, p-mTOR, phospho-p70S6K and PDK1...
  17. Shultis D, Dodge G, Zhang Y. Crystal structure of designed PX domain from cytokine-independent survival kinase and implications on evolution-based protein engineering. J Struct Biol. 2015;191:197-206 pubmed publisher
    ..report the X-ray crystallographic structure of a designed PX domain from the cytokine-independent survival kinase (CISK), which has been implicated as functioning in parallel with PKB/Akt in cell survival and insulin responses...
  18. Liu F, Wu X, Jiang X, Qian Y, Gao J. Prolonged inhibition of class I PI3K promotes liver cancer stem cell expansion by augmenting SGK3/GSK-3β/β-catenin signalling. J Exp Clin Cancer Res. 2018;37:122 pubmed publisher
    Serum and glucocorticoid-regulated kinase 3 (SGK3) has been reported to play an important role in tumour progression, but its role in cancer stem cells (CSCs) remains obscure...
  19. Jin H, Yang L, Wang L, Yang Z, Zhan Q, Tao Y, et al. INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia. J Exp Clin Cancer Res. 2018;37:8 pubmed publisher
    ..After INPP4B overexpression or knockdown, the activation of serum and glucocorticoid-regulated kinase 3 (SGK3) and AKT was assessed...
  20. Minchenko D, Riabovol O, Tsymbal D, Ratushna O, Minchenko O. Inhibition of IRE1 signaling affects the expression of genes encoded glucocorticoid receptor and some related factors and their hypoxic regulation in U87 glioma cells. Endocr Regul. 2016;50:127-36 pubmed publisher
    ..response on the expression of genes encoding glucocorticoid receptor (NR3C1) and some related proteins (SGK1, SGK3, NCOA1, NCOA2, ARHGAP35, NNT) and their hypoxic regulation in U87 glioma cells for evaluation of their possible ..
  21. Nacci L, Valli R, Maria Pinto R, Zecca M, Cipolli M, Morini J, et al. Parental origin of the deletion del(20q) in Shwachman-Diamond patients and loss of the paternally derived allele of the imprinted L3MBTL1 gene. Genes Chromosomes Cancer. 2017;56:51-58 pubmed publisher
    ..We collected 6 SDS cases with del(20q): a cluster of imprinted genes, including L3MBTL1 and SGK2 is present in the deleted region. Only the paternal allele is expressed for these genes...
  22. Ahmed M, Fezai M, Uzcategui N, Hosseinzadeh Z, Lang F. SGK3 Sensitivity of Voltage Gated K+ Channel Kv1.5 (KCNA5). Cell Physiol Biochem. 2016;38:359-67 pubmed publisher
    The serum & glucocorticoid inducible kinase isoform SGK3 is a powerful regulator of several transporters, ion channels and the Na+/K+ ATPase...
  23. Liu S, Zhu B, Sun Y, Xie X. MiR-155 modulates the progression of neuropathic pain through targeting SGK3. Int J Clin Exp Pathol. 2015;8:14374-82 pubmed
    ..05). Serum and glucocorticoid regulated protein kinase 3 (SGK3) was predicted as the target gene for miR-155, and miR-155 expression was negatively correlated to SGK3 expression...
  24. Maier G, Palmada M, Rajamanickam J, Shumilina E, Böhmer C, Lang F. Upregulation of HERG channels by the serum and glucocorticoid inducible kinase isoform SGK3. Cell Physiol Biochem. 2006;18:177-86 pubmed
    ..The present study has been performed to explore whether SGK1 and SGK3 participate in the regulation of HERG channel activity...
  25. Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, et al. Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction. Biochem Biophys Res Commun. 2002;293:1191-6 pubmed
    Serum and glucocorticoid-inducible kinase-like kinase (SGKL) has been identified as a new integrator that decodes lipid signals produced by the activation of phosphoinositide 3-kinase (PI3K)...
  26. Embark H, Böhmer C, Palmada M, Rajamanickam J, Wyatt A, Wallisch S, et al. Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases. Kidney Int. 2004;66:1918-25 pubmed
    ..is stimulated by SGK1, and down-regulated by Nedd4-2, an effect that may be reversed by SGK1 and its isoforms, SGK2 or SGK3...
  27. Yun C, Chen Y, Lang F. Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2. J Biol Chem. 2002;277:7676-83 pubmed
    ..These data demonstrated that glucocorticoid activation of NHE3 requires the activation of SGK1 and the presence of NHERF2 acting as a scaffold protein. ..
  28. Inoue K, Sakuma E, Morimoto H, Asai H, Koide Y, Leng T, et al. Serum- and glucocorticoid-inducible kinases in microglia. Biochem Biophys Res Commun. 2016;478:53-59 pubmed publisher
    ..Here we, for the first time, report that SGK1 and SGK3 are expressed in multiple microglial cell lines. An SGK inhibitor, gsk650394, inhibits cell viability...
  29. Brickley D, Mikosz C, Hagan C, Conzen S. Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1). J Biol Chem. 2002;277:43064-70 pubmed
  30. Hausmann S, Brandt E, Köchel C, Einsele H, Bargou R, Seggewiss Bernhardt R, et al. Loss of serum and glucocorticoid-regulated kinase 3 (SGK3) does not affect proliferation and survival of multiple myeloma cell lines. PLoS ONE. 2015;10:e0122689 pubmed publisher
    ..Here we explore whether serum and glucocorticoid-regulated kinase 3 (SGK3), a potential downstream effector of PI3K, plays a role in oncogenic signalling in MM cells--either in concert with ..
  31. Gasser J, Inuzuka H, Lau A, Wei W, Beroukhim R, Toker A. SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer. Mol Cell. 2014;56:595-607 pubmed publisher
    ..We show that serum and glucocorticoid-regulated kinase 3 (SGK3) is amplified in breast cancer and activated downstream of PIK3CA in a manner dependent on the phosphoinositide ..
  32. Chi M, Guo S, Wilmott J, Guo X, Yan X, Wang C, et al. INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas. Oncotarget. 2015;6:39891-907 pubmed publisher
    ..that INPP4B can function as an oncogenic driver through activation of serum- and glucocorticoid-regulated kinase 3 (SGK3) in melanoma...
  33. Embark H, Böhmer C, Vallon V, Luft F, Lang F. Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms. Pflugers Arch. 2003;445:601-6 pubmed
    ..study has been performed to explore whether the serum- and glucocorticoid-inducible kinase family members SGK1, SGK2, or SGK3 and/or protein kinase B (PKB) influence K(+) channel activity in Xenopus oocytes expressing KCNE1...
  34. Baltaev R, Strutz Seebohm N, Korniychuk G, Myssina S, Lang F, Seebohm G. Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes. Pflugers Arch. 2005;450:26-33 pubmed
    ..3/KChIP2b channel activity in the Xenopus laevis heterologous expression system. Co-expression of SGK1, but not of SGK2 or SGK3, increased Kv 4.3/KChIP2b channel currents...
  35. Boehmer C, Rajamanickam J, Schniepp R, Kohler K, Wulff P, Kuhl D, et al. Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3. Biochem Biophys Res Commun. 2005;329:738-42 pubmed
    ..The study explored the possible regulation of EAAT5 by SGK1, its isoform SGK3, and the closely related protein kinase B...
  36. Böhmer C, Sopjani M, Klaus F, Lindner R, Laufer J, Jeyaraj S, et al. The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19. Cell Physiol Biochem. 2010;25:723-32 pubmed publisher
    ..In conclusion, SGK isoforms are novel potent stimulators of SLC6A19 and may thus participate in the regulation of neutral amino acid transport in vivo. ..
  37. Xu J, Liu D, Gill G, Songyang Z. Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides. J Cell Biol. 2001;154:699-705 pubmed
    ..Unlike Akt, cytokine-independent survival kinase (CISK)/SGK3 contains a Phox homology (PX) domain...
  38. Tessier M, Woodgett J. Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3. J Biol Chem. 2006;281:23978-89 pubmed
    ..Full-length SGK3 contains a complete Phox homology (PX) domain that targets the protein to endosomes...
  39. Fang X, Yu S, Lu Y, Bast R, Woodgett J, Mills G. Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc Natl Acad Sci U S A. 2000;97:11960-5 pubmed
  40. Li X, Su R, Wan W, Zhang W, Jiang H, Qiao X, et al. Identification of selection signals by large-scale whole-genome resequencing of cashmere goats. Sci Rep. 2017;7:15142 pubmed publisher
    ..genomic regions contained genes, which are potential involved in the production of cashmere fiber, such as FGF5, SGK3, IGFBP7, OXTR, and ROCK1...
  41. Munoz C, Pakladok T, Almilaji A, Elvira B, Decher N, Shumilina E, et al. Up-regulation of Kir2.1 (KCNJ2) by the serum & glucocorticoid inducible SGK3. Cell Physiol Biochem. 2014;33:491-500 pubmed publisher
    The serum & glucocorticoid inducible kinase SGK3, an ubiquitously expressed serine/threonine kinase, regulates a variety of ion channels. It has previously been shown that SGK3 upregulates the outwardly rectifying K(+) channel KV11...
  42. Lamothe S, Zhang S. The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11. J Biol Chem. 2013;288:15075-84 pubmed publisher
    ..that overexpression of the stress-responsive serum- and glucocorticoid-inducible kinase (SGK) isoforms SGK1 and SGK3 increased the current and expression level of the membrane-localized mature proteins of hERG channels stably ..
  43. Strutz Seebohm N, Seebohm G, Korniychuk G, Baltaev R, Ureche O, Striegel M, et al. Additive regulation of GluR1 by stargazin and serum- and glucocorticoid-inducible kinase isoform SGK3. Pflugers Arch. 2006;452:276-82 pubmed
    The serum- and glucocorticoid-inducible kinase isoform 3 (SGK3) and stargazin have both been shown to enhance the synaptic expression level of GluR1...
  44. Scortegagna M, Lau E, Zhang T, Feng Y, Sereduk C, Yin H, et al. PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic Targets. Cancer Res. 2015;75:1399-412 pubmed publisher
    ..The PDK1 substrate SGK3 was determined to be an important mediator of PDK1 activities in melanoma cells...
  45. Fang X, Yu S, Tanyi J, Lu Y, Woodgett J, Mills G. Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway. Mol Cell Biol. 2002;22:2099-110 pubmed
    ..LPA and potentially other natural ligands primarily utilize a PKC-dependent pathway to modulate GSK-3. ..
  46. Gamper N, Fillon S, Feng Y, Friedrich B, Lang P, Henke G, et al. K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK. Pflugers Arch. 2002;445:60-6 pubmed
    ..Subsequently, the two homologous kinases SGK2 and SGK3 have been cloned, being products of distinct genes, which are differentially expressed and share 80% ..
  47. Bago R, Sommer E, Castel P, Crafter C, Bailey F, Shpiro N, et al. The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth. EMBO J. 2016;35:1902-22 pubmed publisher
    ..of breast cancer cells with PI3K or Akt inhibitors leads to increased expression and activation of a kinase termed SGK3 that is related to Akt...
  48. Kong X, Liu F, Gao J. MiR-155 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells through the activation of PI3K/SGK3/β-catenin signaling pathways. Oncotarget. 2016;7:66051-66060 pubmed publisher
    ..to be the primary effector of PI3K, but there is evidence to suggest that serum and glucocorticoid kinase 3 (SGK3) acts in an Akt-independent manner downstream of PI3K...
  49. Slagsvold T, Marchese A, Brech A, Stenmark H. CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4. EMBO J. 2006;25:3738-49 pubmed
    ..Here, we provide evidence that the cytokine-independent survival kinase CISK is activated downstream of the PI 3-kinase-dependent kinase PDK1 on endosomes and negatively regulates the ..
  50. Wyatt A, Hussain A, Amann K, Klingel K, Kandolf R, Artunc F, et al. DOCA-induced phosphorylation of glycogen synthase kinase 3beta. Cell Physiol Biochem. 2006;17:137-44 pubmed
    ..The effect of SGK1 was mimicked by PKB and SGK3. Furthermore, DOCA/high salt treatment of wild type mice induced a robust increase in cardiac GSK3beta ..
  51. Shojaiefard M, Christie D, Lang F. Stimulation of the creatine transporter SLC6A8 by the protein kinases SGK1 and SGK3. Biochem Biophys Res Commun. 2005;334:742-6 pubmed
    ..The effect of SGK1 was mimicked by the constitutively active isoform (S419D)SGK3 but not by inactive (K119N)SGK3, wild type isoform SGK2 or constitutively active related kinase (T308D,S473D)PKB...
  52. Malik N, MacArtney T, Hornberger A, Anderson K, Tovell H, Prescott A, et al. Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks. Biochem J. 2018;475:117-135 pubmed publisher
    ..Recent work has revealed that the poorly studied AGC kinase family member, SGK3, promotes resistance to cancer therapies that target the Class 1 PI3K pathway, by substituting for loss of Akt ..
  53. Loffing J, Flores S, Staub O. Sgk kinases and their role in epithelial transport. Annu Rev Physiol. 2006;68:461-90 pubmed
    ..In this review we first discuss the molecular, cellular, and regulatory aspects of Sgk1 and its paralogs. We then discuss its roles in the physiology and pathophysiology of epithelial ion transport. ..
  54. Liu M, Chen L, Chan T, Wang J, Li Y, Zeng T, et al. Serum and glucocorticoid kinase 3 at 8q13.1 promotes cell proliferation and survival in hepatocellular carcinoma. Hepatology. 2012;55:1754-65 pubmed publisher
    ..In this report we examine the potential role of the candidate amplified oncogene serum and glucocorticoid kinase 3 (SGK3) at 8q13.1 in HCC pathogenesis...
  55. Wang Y, Xu W, Zhou D, Neckers L, Chen S. Coordinated regulation of serum- and glucocorticoid-inducible kinase 3 by a C-terminal hydrophobic motif and Hsp90-Cdc37 chaperone complex. J Biol Chem. 2014;289:4815-26 pubmed publisher
    Serum- and glucocorticoid-inducible kinase 3 (SGK3) mediates a variety of cellular processes including membrane transport, cell proliferation, and survival, and it has been implicated in Akt-independent signaling downstream of oncogenic ..
  56. Wang Y, Zhou D, Chen S. SGK3 is an androgen-inducible kinase promoting prostate cancer cell proliferation through activation of p70 S6 kinase and up-regulation of cyclin D1. Mol Endocrinol. 2014;28:935-48 pubmed publisher
    ..Here we report that serum- and glucocorticoid-inducible kinase 3 (SGK3), a Ser/Thr kinase functioning downstream of PI3K, is an AR transcriptional target and promotes prostate cancer ..
  57. Bilanges B, Vanhaesebroeck B. Cinderella finds her shoe: the first Vps34 inhibitor uncovers a new PI3K-AGC protein kinase connection. Biochem J. 2014;464:e7-10 pubmed publisher
    ..Like other AGC kinases, the SGKs (SGK1, SGK2 and SGK3) are activated by dual phosphorylation...
  58. Gan W, Li T, Ren J, Li C, Liu Z, Yang M. Serum-glucocorticoid-regulated kinase 1 contributes to mechanical stretch-induced inflammatory responses in cardiac fibroblasts. Mol Cell Biochem. 2018;445:67-78 pubmed publisher
    ..mechanical stretch increased SGK1 expression and activation in WT cardiac fibroblasts but not its isoform, SGK2 or SGK3 expression...
  59. Dou L, Lin H, Wang K, Zhu G, Zou X, Chang E, et al. Long non-coding RNA CCAT1 modulates neuropathic pain progression through sponging miR-155. Oncotarget. 2017;8:89949-89957 pubmed publisher
    ..that lncRNA CCAT1 decreased miR-155 expression and enhanced Serum and glucocorticoid regulated protein kinase 3 (SGK3) expression in the NGF-differentiated PC12 cell...
  60. Wang Y, Zhou D, Phung S, Warden C, Rashid R, Chan N, et al. SGK3 sustains ERα signaling and drives acquired aromatase inhibitor resistance through maintaining endoplasmic reticulum homeostasis. Proc Natl Acad Sci U S A. 2017;114:E1500-E1508 pubmed publisher
    ..Here, we report that serum- and glucocorticoid-inducible kinase 3 (SGK3), a kinase transcriptionally regulated by ERα in breast cancer, sustains ERα signaling and drives acquired AI ..
  61. Xu J, Liao L, Qin J, Xu J, Liu D, Songyang Z. Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISK. J Biol Chem. 2009;284:14377-85 pubmed publisher
    ..Both Akt and cytokine-independent survival kinase (CISK)/SGK3 are known AGC family protein kinases that function downstream of PI 3-kinase...
  62. Friedrich B, Feng Y, Cohen P, Risler T, Vandewalle A, Broer S, et al. The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC. Pflugers Arch. 2003;445:693-6 pubmed
    ..More recently, two isoforms, SGK2 and SGK3, have been cloned...
  63. Henke G, Setiawan I, Böhmer C, Lang F. Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms. Kidney Blood Press Res. 2002;25:370-4 pubmed
    ..SGK1 and the two isoforms SGK2 and SGK3 are stimulated by insulin and insulin-like growth factor-1 (IGF-1), which have been shown to enhance Na(+)/K(+)-..
  64. Ali A, Hoeflich K, Woodgett J. Glycogen synthase kinase-3: properties, functions, and regulation. Chem Rev. 2001;101:2527-40 pubmed
  65. Stobdan T, Akbari A, Azad P, Zhou D, Poulsen O, Appenzeller O, et al. New insights into the genetic basis of Monge's disease and adaptation to high-altitude. Mol Biol Evol. 2017;: pubmed publisher
    ..g., SENP1) and also unreported ones SGK3, COPS5, PRDM1 and IFT122 in CMS...
  66. Peng L, Zhao H, Liu S, Yuan Y, Yuan C, Mwamunyi M, et al. Lack of serum- and glucocorticoid-inducible kinase 3 leads to podocyte dysfunction. FASEB J. 2017;: pubmed publisher
    Serum- and glucocorticoid-inducible kinase 3 (SGK3) is a downstream mediator of PI3K, which is essential for maintaining the functional integrity of podocytes. However, little is known about the role of SGK3 in podocyte function...
  67. Gotoh S, Miyauchi Y, Moore R, Negishi M. Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal. Cell Signal. 2017;40:200-209 pubmed publisher
    ..This PP2Cα dephosphorylates serine/threonine kinase 2 (SGK2) at Thr193...
  68. Mouton V, Toussaint L, Vertommen D, Gueuning M, Maisin L, Havaux X, et al. Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3). Biochem J. 2010;431:267-75 pubmed publisher
    ..Therefore we first tested whether SGK3 (serum- and glucocorticoid-induced protein kinase 3) might be involved in this effect...
  69. Nilsen T, Slagsvold T, Skjerpen C, Brech A, Stenmark H, Olsnes S. Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner. J Biol Chem. 2004;279:4794-801 pubmed
    ..The cytokine-independent survival kinase (CISK) containing a PTS tag was not efficiently targeted to the peroxisomes unless the Phox homology (PX) domain, ..
  70. Lang F, Cohen P. Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms. Sci STKE. 2001;2001:re17 pubmed
    ..In contrast, little is known about the transcriptional regulation of the two closely related isoforms SGK2 and SGK3, although they can be activated by phosphorylation...
  71. Dai F, Yu L, He H, Zhao Y, Yang J, Zhang X, et al. Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1. Genomics. 1999;62:95-7 pubmed
    ..In this paper, we reported the cloning of human SGKL, which encodes a protein sharing 67 and 66% amino acid identity with rat sgk and human SGK, respectively. A 4...