Gene Symbol: SGK2
Description: SGK2, serine/threonine kinase 2
Alias: H-SGK2, dJ138B7.2, serine/threonine-protein kinase Sgk2, serum/glucocorticoid regulated kinase 2
Species: human
Products:     SGK2

Top Publications

  1. Liu Y, Chen J, Zhang M, Zhang X, Meng J, Zhou J, et al. SGK2 promotes renal cancer progression via enhancing ERK 1/2 and AKT phosphorylation. Eur Rev Med Pharmacol Sci. 2019;23:2756-2767 pubmed publisher
    ..In this article, we are aiming to explore the function of SGK2 in renal cell cancer (RCC)...
  2. Wang H, Zhang J, You G. The mechanistic links between insulin and human organic anion transporter 4. Int J Pharm. 2019;555:165-174 pubmed publisher
    ..Interestingly, in cells overexpressing sgk2, the stimulatory effect of insulin on hOAT4 was diminished...
  3. Caballero Solares A, Xue X, Parrish C, Foroutani M, Taylor R, Rise M. Changes in the liver transcriptome of farmed Atlantic salmon (Salmo salar) fed experimental diets based on terrestrial alternatives to fish meal and fish oil. BMC Genomics. 2018;19:796 pubmed publisher
    ..the transcription of genes involved in carbohydrate metabolism (gck and pfkfb4), cell growth and proliferation (sgk2 and htra1), apoptosis (gadd45b), lipid metabolism (fabp3, idi1, sqs), and immunity (igd, mx, ifit5, and mhcI)...
  4. Gong G, Wang K, Dai X, Zhou Y, Basnet R, Chen Y, et al. Identification, structure modification, and characterization of potential small-molecule SGK3 inhibitors with novel scaffolds. Acta Pharmacol Sin. 2018;39:1902-1912 pubmed publisher
    ..SGK family consists of three isoforms (SGK1, SGK2, and SGK3), which have high sequence homology in the kinase domain and similar substrate specificity with the AKT ..
  5. Bilanges B, Vanhaesebroeck B. Cinderella finds her shoe: the first Vps34 inhibitor uncovers a new PI3K-AGC protein kinase connection. Biochem J. 2014;464:e7-10 pubmed publisher
    ..Like other AGC kinases, the SGKs (SGK1, SGK2 and SGK3) are activated by dual phosphorylation...
  6. Talarico C, Dattilo V, D Antona L, Menniti M, Bianco C, Ortuso F, et al. SGK1, the New Player in the Game of Resistance: Chemo-Radio Molecular Target and Strategy for Inhibition. Cell Physiol Biochem. 2016;39:1863-1876 pubmed
    The serum- and glucocorticoid-regulated kinase (SGK) family consists of three members, SGK1, SGK2 and SGK3, all displaying serine/threonine kinase activity and sharing structural and functional similarities with the AKT family of kinases...
  7. Zhang D, Gu D, He J, Hixson J, Rao D, Li C, et al. Associations of the Serum/Glucocorticoid Regulated Kinase Genes With BP Changes and Hypertension Incidence: The Gensalt Study. Am J Hypertens. 2017;30:95-101 pubmed
    ..4×10-3). No evidence for the SGK2 and SGK3 genes was found...
  8. Gamper N, Fillon S, Feng Y, Friedrich B, Lang P, Henke G, et al. K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK. Pflugers Arch. 2002;445:60-6 pubmed
    ..Subsequently, the two homologous kinases SGK2 and SGK3 have been cloned, being products of distinct genes, which are differentially expressed and share 80% ..
  9. Liu J, Zhang G, Lv Y, Zhang X, Ying C, Yang S, et al. SGK2 promotes hepatocellular carcinoma progression and mediates GSK-3?/?-catenin signaling in HCC cells. Tumour Biol. 2017;39:1010428317700408 pubmed publisher
    ..serum/glucocorticoid-regulated kinase (SGK) family of serine/threonine kinases consists of three isoforms, SGK1, SGK2, and SGK3...

More Information


  1. Gotoh S, Negishi M. Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis. Sci Rep. 2015;5:14076 pubmed publisher
    ..Statins utilize pregnane X receptor (PXR) and serum/glucocorticoid regulated kinase 2 (SGK2) to activate phosphoenolpyruvate carboxykinase 1 (PEPCK1) and glucose-6-phosphatase (G6Pase) genes, thereby ..
  2. Gan W, Li T, Ren J, Li C, Liu Z, Yang M. Serum-glucocorticoid-regulated kinase 1 contributes to mechanical stretch-induced inflammatory responses in cardiac fibroblasts. Mol Cell Biochem. 2018;445:67-78 pubmed publisher
    ..that mechanical stretch increased SGK1 expression and activation in WT cardiac fibroblasts but not its isoform, SGK2 or SGK3 expression...
  3. Gotoh S, Miyauchi Y, Moore R, Negishi M. Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal. Cell Signal. 2017;40:200-209 pubmed publisher
    ..This PP2Cα dephosphorylates serine/threonine kinase 2 (SGK2) at Thr193...
  4. Kobayashi T, Deak M, Morrice N, Cohen P. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. Biochem J. 1999;344 Pt 1:189-97 pubmed
    ..Here we identify two novel isoforms of SGK, termed SGK2 and SGK3, whose catalytic domains share 80% amino acid sequence identity with each other and with SGK (renamed SGK1)..
  5. Bruhn M, Pearson R, Hannan R, Sheppard K. Second AKT: the rise of SGK in cancer signalling. Growth Factors. 2010;28:394-408 pubmed publisher
    ..Here, we will review the current state of knowledge on the regulation of the SGKs and their role in normal cell physiology and transformation with a particular focus on SGK3. ..
  6. Loffing J, Flores S, Staub O. Sgk kinases and their role in epithelial transport. Annu Rev Physiol. 2006;68:461-90 pubmed
    ..In this review we first discuss the molecular, cellular, and regulatory aspects of Sgk1 and its paralogs. We then discuss its roles in the physiology and pathophysiology of epithelial ion transport. ..
  7. Baltaev R, Strutz Seebohm N, Korniychuk G, Myssina S, Lang F, Seebohm G. Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes. Pflugers Arch. 2005;450:26-33 pubmed
    ..3/KChIP2b channel activity in the Xenopus laevis heterologous expression system. Co-expression of SGK1, but not of SGK2 or SGK3, increased Kv 4.3/KChIP2b channel currents...
  8. NARAY FEJES TOTH A, Helms M, Stokes J, Fejes Toth G. Regulation of sodium transport in mammalian collecting duct cells by aldosterone-induced kinase, SGK1: structure/function studies. Mol Cell Endocrinol. 2004;217:197-202 pubmed
    ..In this study, we determined that the two recently described isoforms, SGK2 and SGK3 are also expressed in renal cortical collecting duct (CCD) cells; however, their expression is not induced ..
  9. Friedrich B, Feng Y, Cohen P, Risler T, Vandewalle A, Broer S, et al. The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC. Pflugers Arch. 2003;445:693-6 pubmed
    ..It is therefore thought to participate in the antinatriuretic action of this hormone. More recently, two isoforms, SGK2 and SGK3, have been cloned...
  10. Lang F, Cohen P. Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms. Sci STKE. 2001;2001:re17 pubmed
    ..In contrast, little is known about the transcriptional regulation of the two closely related isoforms SGK2 and SGK3, although they can be activated by phosphorylation...
  11. Wang H, Xu D, Toh M, Pao A, You G. Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2. Biochem Pharmacol. 2016;102:120-129 pubmed publisher
    ..In the current study, we examined the regulation of hOAT4 by serum- and glucocorticoid-inducible kinase 2 (sgk2) in the kidney COS-7 cells. We showed that sgk2 stimulated hOAT4 transport activity...
  12. Nacci L, Valli R, Maria Pinto R, Zecca M, Cipolli M, Morini J, et al. Parental origin of the deletion del(20q) in Shwachman-Diamond patients and loss of the paternally derived allele of the imprinted L3MBTL1 gene. Genes Chromosomes Cancer. 2017;56:51-58 pubmed publisher
    ..We collected 6 SDS cases with del(20q): a cluster of imprinted genes, including L3MBTL1 and SGK2 is present in the deleted region. Only the paternal allele is expressed for these genes...
  13. Gotoh S, Negishi M. Serum- and glucocorticoid-regulated kinase 2 determines drug-activated pregnane X receptor to induce gluconeogenesis in human liver cells. J Pharmacol Exp Ther. 2014;348:131-40 pubmed publisher
    ..In this study, we have determined that serum- and glucocorticoid-regulated kinase 2 (SGK2) is an essential factor that mediates this PXR-regulated glucose 6-phosphatase (G6Pase) induction and glucose ..
  14. Böhmer C, Sopjani M, Klaus F, Lindner R, Laufer J, Jeyaraj S, et al. The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19. Cell Physiol Biochem. 2010;25:723-32 pubmed publisher
    ..In conclusion, SGK isoforms are novel potent stimulators of SLC6A19 and may thus participate in the regulation of neutral amino acid transport in vivo. ..
  15. Embark H, Böhmer C, Vallon V, Luft F, Lang F. Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms. Pflugers Arch. 2003;445:601-6 pubmed has been performed to explore whether the serum- and glucocorticoid-inducible kinase family members SGK1, SGK2, or SGK3 and/or protein kinase B (PKB) influence K(+) channel activity in Xenopus oocytes expressing KCNE1...