Gene Symbol: SGF29
Description: SAGA complex associated factor 29
Alias: CCDC101, STAF36, TDRD29, SAGA-associated factor 29, SAGA-associated factor 29 homolog, coiled-coil domain containing 101, coiled-coil domain-containing protein 101
Bian C, Xu C, Ruan J, Lee K, Burke T, Tempel W, et al
. Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. EMBO J. 2011;30:2829-42 pubmed publisher
..b>Sgf29 is a novel component of the SAGA complex...
Lang G, Bonnet J, Umlauf D, Karmodiya K, Koffler J, Stierlé M, et al
. The tightly controlled deubiquitination activity of the human SAGA complex differentially modifies distinct gene regulatory elements. Mol Cell Biol. 2011;31:3734-44 pubmed publisher
Holmlund T, Lindberg M, Grander D, Wallberg A. GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia. Leukemia. 2013;27:578-85 pubmed publisher
..In addition, we show that the E3 ubiquitin ligase HDM2 potentiates the degradation of E2A-PBX1. We suggest that dynamic regulation of E2A-PBX1 protein levels in vivo has a fundamental role in ALL. ..
Wang Y, Faiola F, Xu M, Pan S, Martinez E. Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. J Biol Chem. 2008;283:33808-15 pubmed publisher
..ATAC complexes incorporate in addition to GCN5 or PCAF (GCN5/PCAF), other epigenetic coregulators (ADA2-A, ADA3, STAF36, and WDR5), cofactors of chromatin assembly/remodeling and DNA replication machineries (POLE3/CHRAC17 and POLE4), ..
Schram A, Baas R, Jansen P, Riss A, Tora L, Vermeulen M, et al
. A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation. PLoS ONE. 2013;8:e70035 pubmed publisher
The SGF29 protein binds to tri-methylated lysine-4 of histone H3 (H3K4me3), which is a histone modification associated with active promoters...
Pieters B, Meulenbroeks E, Belle R, MecinoviÄ‡ J. The Role of Electrostatic Interactions in Binding of Histone H3K4me2/3 to the Sgf29 Tandem Tudor Domain. PLoS ONE. 2015;10:e0139205 pubmed publisher
..we report thermodynamic analyses for the recognition of histone H3K4me3 and H3K4me2 by the tandem tudor domain of Sgf29 and its recognition site variants...
Kurabe N, Katagiri K, Komiya Y, Ito R, Sugiyama A, Kawasaki Y, et al
. Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-Myc. Oncogene. 2007;26:5626-34 pubmed
..complex are well conserved between yeast and mammals, four mammalian orthologs of yeast SPT8, SPT20, SGF11 and SGF29 remain to be identified...
Imielinski M, Baldassano R, Griffiths A, Russell R, Annese V, Dubinsky M, et al
. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet. 2009;41:1335-40 pubmed publisher
Palhan V, Chen S, Peng G, Tjernberg A, Gamper A, Fan Y, et al
. Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Proc Natl Acad Sci U S A. 2005;102:8472-7 pubmed