Gene Symbol: SGCZ
Description: sarcoglycan zeta
Alias: ZSG1, zeta-sarcoglycan, zeta-SG
Species: human
Products:     SGCZ

Top Publications

  1. Wheeler M, Zarnegar S, McNally E. Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy. Hum Mol Genet. 2002;11:2147-54 pubmed
    ..Together, these data demonstrate that zeta-sarcoglycan is an integral component of the sarcoglycan complex and, as such, is important in the pathogenesis of muscular dystrophy. ..
  2. Chen X, Long F, Cai B, Chen X, Qin L, Chen G. A Novel Relationship for Schizophrenia, Bipolar, and Major Depressive Disorder. Part 8: a Hint from Chromosome 8 High Density Association Screen. Mol Neurobiol. 2017;54:5868-5882 pubmed publisher
    ..were comprehensively revealed, and outstanding susceptibility genes were identified including CSMD1, NRG1, PXDNL, SGCZ, and TMEM66. Unexpectedly, flanking genes for up to 95.9 % of the associated SNPs were replicated (P ? 9...
  3. Li M, Liu F, Zhang Y, Wu X, Wu W, Wang X, et al. Whole-genome sequencing reveals the mutational landscape of metastatic small-cell gallbladder neuroendocrine carcinoma (GB-SCNEC). Cancer Lett. 2017;391:20-27 pubmed publisher
    ..Two gene fusions, NCAM2-SGCZ and BTG3-CCDC40 were also discovered and validated by Sanger sequencing...
  4. Azarbarzin S, Feizi M, Safaralizadeh R, Kazemzadeh M, Fateh A. The Value of MiR-383, an Intronic MiRNA, as a Diagnostic and Prognostic Biomarker in Intestinal-Type Gastric Cancer. Biochem Genet. 2017;55:244-252 pubmed publisher
    ..MiR-383 is placed in intron of SGCZ, a protein-coding gene, which is subject to dysregulation in various diseases...
  5. Levy R, Mott R, Iraqi F, Gabet Y. Collaborative cross mice in a genetic association study reveal new candidate genes for bone microarchitecture. BMC Genomics. 2015;16:1013 pubmed publisher
    ..Th), Rb1, and Cpb2 (with Conn.D). Other candidate genes strongly suggested by our analyses are Sgcz, Fgf20 (associated with Tb.N), and Chd2 (with Tb.Th)...
  6. Jin H, Li D, Sivakumaran H, Lor M, Rustanti L, Cloonan N, et al. Shutdown of HIV-1 Transcription in T Cells by Nullbasic, a Mutant Tat Protein. MBio. 2016;7: pubmed publisher
    ..Here we show that lentiviral vectors that constitutively express a Nullbasic-ZsGreen1 (NB-ZSG1) fusion protein by the eEF1? promoter led to robust long-term inhibition of HIV-1 replication in Jurkat cells...
  7. Rustanti L, Jin H, Lor M, Lin M, Rawle D, Harrich D. A mutant Tat protein inhibits infection of human cells by strains from diverse HIV-1 subtypes. Virol J. 2017;14:52 pubmed publisher
    ..We also examined antiviral activity of Nullbasic-ZsGreen1 (NB-ZSG1) fusion protein against the same strains in primary CD4+ T cells...
  8. Aurino S, Piluso G, Saccone V, Cacciottolo M, D Amico F, Dionisi M, et al. Candidate-gene testing for orphan limb-girdle muscular dystrophies. Acta Myol. 2008;27:90-7 pubmed
    ..We identified a large number of variations in any of the genes in both patients and controls. Correlations with disease or possible modifying effects on the LGMD phenotype remain to be investigated. ..
  9. Anastasi G, Cutroneo G, Sidoti A, Rinaldi C, Bruschetta D, Rizzo G, et al. Sarcoglycan subcomplex expression in normal human smooth muscle. J Histochem Cytochem. 2007;55:831-43 pubmed

More Information


  1. Baulac S, Gourfinkel An I, Couarch P, Depienne C, Kaminska A, Dulac O, et al. A novel locus for generalized epilepsy with febrile seizures plus in French families. Arch Neurol. 2008;65:943-51 pubmed publisher
    ..We have not, so far, identified mutations in the coding exons of 6 candidate genes (MTMR9, MTMR7, CTSB, SGCZ, SG223, and ATP6V1B2) located in the genetic interval. We report a sixth locus for GEFS(+) on chromosome 8p23-p21...
  2. Johnson A, Yanek L, Chen M, Faraday N, Larson M, Tofler G, et al. Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. Nat Genet. 2010;42:608-13 pubmed publisher
    ..05 in an additional African-American cohort (N<or=840 in the Genetic Study of Atherosclerosis Risk). These results provide insights into platelet aggregation pathways and may suggest new antiplatelet therapeutic targets. ..
  3. Zhao W, Wineinger N, Tiwari H, Mosley T, Broeckel U, Arnett D, et al. Copy number variations associated with obesity-related traits in African Americans: a joint analysis between GENOA and HyperGEN. Obesity (Silver Spring). 2012;20:2431-7 pubmed publisher
    ..These CNVs overlap the PARK2, GYPA, and SGCZ genes. Our results suggest that CNV may play a role in the etiology of obesity in AAs.
  4. Ikeda M, Okahisa Y, Aleksic B, Won M, Kondo N, Naruse N, et al. Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia. Neuropsychopharmacology. 2013;38:1864-70 pubmed publisher
    ..These also suggest that the overlap between genes scored as positive in these data sets can have higher probability as susceptibility genes for psychosis. ..
  5. Peall K, Ritz K, Waite A, Groen J, Morris H, Baas F, et al. SGCZ mutations are unlikely to be associated with myoclonus dystonia. Neuroscience. 2014;272:88-91 pubmed publisher
    ..E- and ?-sarcoglycan are both expressed in brain tissue. In this study we tested whether zeta-sarcoglycan gene (SGCZ) mutations also contribute to this disorder...
  6. Kibriya M, Jasmine F, Parvez F, Argos M, Roy S, Paul Brutus R, et al. Association between genome-wide copy number variation and arsenic-induced skin lesions: a prospective study. Environ Health. 2017;16:75 pubmed publisher
    ..The presence of genomic deletion(s) in a number of genes (OR5J2, GOLGA6L7P, APBA2, GALNTL5, VN1R31P, PHKG1P2, SGCZ, ZNF658) and lincRNA genes (RP11-76I14.1, CTC-535 M15.2, RP11-73B2...