SGCG

Summary

Gene Symbol: SGCG
Description: sarcoglycan gamma
Alias: 35DAG, DAGA4, DMDA, DMDA1, LGMD2C, MAM, SCARMD2, SCG3, gamma-SG, gamma-sarcoglycan, 35 kDa dystrophin-associated glycoprotein, 35kD dystrophin-associated glycoprotein, sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
Species: human
Products:     SGCG

Top Publications

  1. Noguchi S, McNally E, Ben Othmane K, Hagiwara Y, Mizuno Y, Yoshida M, et al. Mutations in the dystrophin-associated protein gamma-sarcoglycan in chromosome 13 muscular dystrophy. Science. 1995;270:819-22 pubmed
    ..These mutations not only affect gamma-sarcoglycan but also disrupt the integrity of the entire sarcoglycan complex. ..
  2. Jung D, Leturcq F, Sunada Y, Duclos F, Tome F, Moomaw C, et al. Absence of gamma-sarcoglycan (35 DAG) in autosomal recessive muscular dystrophy linked to chromosome 13q12. FEBS Lett. 1996;381:15-20 pubmed
    ..In addition, we show that in normal muscle alpha-, beta-, and gamma-sarcoglycan constitute a tightly associated sarcolemma complex which cannot be disrupted by SDS treatment. ..
  3. McNally E, Duggan D, Gorospe J, Bonnemann C, Fanin M, Pegoraro E, et al. Mutations that disrupt the carboxyl-terminus of gamma-sarcoglycan cause muscular dystrophy. Hum Mol Genet. 1996;5:1841-7 pubmed
    ..This region of gamma-sarcoglycan, like beta-sarcoglycan, has a number of cysteine residues similar to those in epidermal growth factor cysteine-rich regions. ..
  4. Piccolo F, Jeanpierre M, Leturcq F, Dode C, Azibi K, Toutain A, et al. A founder mutation in the gamma-sarcoglycan gene of gypsies possibly predating their migration out of India. Hum Mol Genet. 1996;5:2019-22 pubmed
    ..They were linked to the LGMD2C locus (13q12) suggesting a primary defect in the gamma-SG gene coding for the 35 kDa dystrophin-associated ..
  5. Barresi R, Moore S, Stolle C, Mendell J, Campbell K. Expression of gamma -sarcoglycan in smooth muscle and its interaction with the smooth muscle sarcoglycan-sarcospan complex. J Biol Chem. 2000;275:38554-60 pubmed
    ..Taken together, our results prove that the sarcoglycan complex in vascular and visceral smooth muscle consists of epsilon-, beta-, gamma-, and delta-sarcoglycans and is associated with sarcospan. ..
  6. Georgieva B, Todorova A, Tournev I, Mitev V, Kremensky I. C283Y gamma-sarcoglycan gene mutation in the Bulgarian Roma (Gypsy) population: prevalence study and carrier screening in a high-risk community. Clin Genet. 2004;66:467-72 pubmed
    Limb-girdle muscular dystrophy type 2C (LGMD2C) is caused by mutations in the gamma-sarcoglycan gene where a founder Gypsy mutation C283Y was detected...
  7. Klinge L, Dekomien G, Aboumousa A, Charlton R, Epplen J, Barresi R, et al. Sarcoglycanopathies: can muscle immunoanalysis predict the genotype?. Neuromuscul Disord. 2008;18:934-41 pubmed publisher
    ..alpha-, beta-, gamma-, delta-sarcoglycan) can be found in patients with limb-girdle muscular dystrophy 2C-F (LGMD2C-F) and also in patients with Duchenne and Becker muscular dystrophy (DMD/BMD)...
  8. Chan Y, Bonnemann C, Lidov H, Kunkel L. Molecular organization of sarcoglycan complex in mouse myotubes in culture. J Cell Biol. 1998;143:2033-44 pubmed
  9. Duncan D, Kang P, Rabbat J, Briggs C, Lidov H, Darras B, et al. A novel mutation in two families with limb-girdle muscular dystrophy type 2C. Neurology. 2006;67:167-9 pubmed
    ..Patients 1 and 2 had a novel homozygous E263K missense mutation on exon 8 of gamma-sarcoglycan (SGCG). Patient 3 had del521T on her maternal allele and an exon 6 deletion on her paternal allele...

More Information

Publications126 found, 100 shown here

  1. Suriyonplengsaeng C, Dejthevaporn C, Khongkhatithum C, Sanpapant S, Tubthong N, Pinpradap K, et al. Immunohistochemistry of sarcolemmal membrane-associated proteins in formalin-fixed and paraffin-embedded skeletal muscle tissue: a promising tool for the diagnostic evaluation of common muscular dystrophies. Diagn Pathol. 2017;12:19 pubmed publisher
    ..tool for the diagnosis of some muscular dystrophies, dystrophinopathies, sarcoglycanopathies (LGMD2D, LGMD2E, and LGMD2C), and dysferlinopathy, especially in situations where the analysis of fresh frozen muscle samples is not routinely ..
  2. Gul W, Gul S, Stamper B, Godfrey M, ElSohly M. LC-MS-MS Method Development and Analysis of Stimulants, Opiates, Synthetic Opiates, PCP, and Benzodiazepines in Wastewater. Preponderance of these Drugs During Football Games. Methods Mol Biol. 2018;1810:149-182 pubmed publisher
    ..MDEA) (5), benzoylecgonine (BE, the major metabolite of Coc) (6), cocaine (Coc) (7), 6-monoacetylmorphine (6-MAM, the primary urinary metabolite of heroin) (8), codeine (9), hydrocodone (10), hydromorphone (11), morphine (12), ..
  3. Li C, Solomons N, Scott M, Koski K. Minerals and Trace Elements in Human Breast Milk Are Associated with Guatemalan Infant Anthropometric Outcomes within the First 6 Months. J Nutr. 2016;146:2067-2074 pubmed
    ..In this cross-sectional study, breast-milk samples were collected from Mam-Mayan mothers during transitional (5-17 d, n = 56), early (18-46 d, n = 75), and established (4-6 mo, n = 103) ..
  4. Rieusset J, Fauconnier J, Paillard M, Belaidi E, Tubbs E, Chauvin M, et al. Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance. Diabetologia. 2016;59:614-23 pubmed publisher
    ..Here, we report on the mechanisms by which disruption of MAM integrity induces hepatic insulin resistance in CypD (also known as Ppif)-knockout (KO) mice...
  5. Issop L, Fan J, Lee S, Rone M, Basu K, Mui J, et al. Mitochondria-associated membrane formation in hormone-stimulated Leydig cell steroidogenesis: role of ATAD3. Endocrinology. 2015;156:334-45 pubmed publisher
    ..Taken together, these results demonstrate that the hormone-induced, ATAD3-mediated, MAM formation participates in the optimal transfer of cholesterol from the ER into mitochondria for steroidogenesis.
  6. Sun Y, Kuek V, Qiu H, Tickner J, Chen L, Wang H, et al. The emerging role of NPNT in tissue injury repair and bone homeostasis. J Cell Physiol. 2018;233:1887-1894 pubmed publisher
    ..EGF)-like superfamily and exhibits several common structural determinants; including EGF-like repeat domains, MAM domain (Meprin, A5 Protein, and Receptor Protein-Tyrosine Phosphatase µ), RGD motif (Arg-Gly-Asp) and a coiled-..
  7. Doghman Bouguerra M, Granatiero V, Sbiera S, Sbiera I, Lacas Gervais S, Brau F, et al. FATE1 antagonizes calcium- and drug-induced apoptosis by uncoupling ER and mitochondria. EMBO Rep. 2016;17:1264-80 pubmed publisher
    ..Mitochondrial Ca(2+) uptake mainly takes place in correspondence of mitochondria-associated ER membranes (MAM), specialized contact sites between the two organelles...
  8. Santacatterina F, Chamorro M, de Arenas C, Navarro C, Martín M, Cuezva J, et al. Quantitative analysis of proteins of metabolism by reverse phase protein microarrays identifies potential biomarkers of rare neuromuscular diseases. J Transl Med. 2015;13:65 pubmed publisher
    ..symptomatic forms of DMD and BMD in female carriers (Xp21 Carriers), Limb Girdle Muscular Dystrophy Type 2C (LGMD2C), neuronal ceroid lipofuscinosis (NCL), glycogenosis type V (Mc Ardle disease), isolated mitochondrial complex I ..
  9. Venco P, Bonora M, Giorgi C, Papaleo E, Iuso A, Prokisch H, et al. Mutations of C19orf12, coding for a transmembrane glycine zipper containing mitochondrial protein, cause mis-localization of the protein, inability to respond to oxidative stress and increased mitochondrial Ca²⁺. Front Genet. 2015;6:185 pubmed publisher
    ..C19orf12 protein was not exclusively present in mitochondria, but also in the Endoplasmic Reticulum (ER) and MAM (Mitochondria Associated Membrane), while mutant C19orf12 variants presented a different localization...
  10. Viaud M, Ivanov S, Vujić N, Duta Mare M, Aira L, Barouillet T, et al. Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol Production. Circ Res. 2018;122:1369-1384 pubmed publisher
    ..Our findings position lysosomal cholesterol hydrolysis as a critical process that prevents metabolic inflammation by enabling efficient macrophage apoptotic cell clearance. ..
  11. Boczonadi V, Meyer K, Gonczarowska Jorge H, Griffin H, Roos A, Bartsakoulia M, et al. Mutations in glycyl-tRNA synthetase impair mitochondrial metabolism in neurons. Hum Mol Genet. 2018;27:2187-2204 pubmed publisher
    ..Our data suggest that altered mitochondria-associated endoplasmic reticulum (ER) membranes (MAM) may be important disease mechanisms leading to neuropathy in this condition.
  12. Martin L, Kennedy B, Karten B. Mitochondrial cholesterol: mechanisms of import and effects on mitochondrial function. J Bioenerg Biomembr. 2016;48:137-51 pubmed publisher
    ..Subdomains of the endoplasmic reticulum (ER), termed mitochondria-associated ER membranes (MAM), form membrane contact sites with mitochondria and may contribute to the transport of ER cholesterol to ..
  13. Zeng Q, Wang Q, Chen X, Xia K, Tang J, Zhou X, et al. Analysis of lncRNAs expression in UVB-induced stress responses of melanocytes. J Dermatol Sci. 2016;81:53-60 pubmed publisher
    ..TYR mRNA expression and activity were re-analysed after transfecting of lnc-CD1D-2:1 siRNA and lnc-SGCG-5:4 siRNA in UVB-irradiated melanocytes to confirm the roles of the two lncRNAs in the synthesis of melanin...
  14. Owuondo P, Mwaura Tenembergen W, Adoyo M, Kiilu E. Preparedness of County Referral Health Facilities in Implementing Adolescent Friendly Health Services: A Case Study of Mama Lucy Kibaki Hospital. Glob J Health Sci. 2015;7:11-23 pubmed publisher
    ..sectional design and semi-structured questionnaire to interview 348 health care providers and 472 adolescents in Mam Lucy Kibaki Hospital from 3rd May 2014 to 16 June 2014...
  15. Omidi A, Kashani I, Akbari M, Mortezaee K, Ghasemi S, Beyer C, et al. Homing of allogeneic nestin-positive hair follicle-associated pluripotent stem cells after maternal transplantation in experimental model of cortical dysplasia. Biochem Cell Biol. 2015;93:619-25 pubmed publisher
    ..delivered on day 16 of gestation in BALB/c mice, which intraperitoneally received methylazoxymethanol (MAM) one day in advance, and homing was assessed at 24 h after cell injection...
  16. Hellquist A, Zucchelli M, Lindgren C, Saarialho Kere U, Järvinen T, Koskenmies S, et al. Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE). PLoS ONE. 2009;4:e8037 pubmed publisher
    ..two independent case-control cohorts from Finland and Sweden, indicated that a novel uncharacterized gene, MAMDC1 (MAM domain containing glycosylphosphatidylinositol anchor 2, also known as MDGA2, MIM 611128), represents a putative ..
  17. Bernard Marissal N, Chrast R, Schneider B. Endoplasmic reticulum and mitochondria in diseases of motor and sensory neurons: a broken relationship?. Cell Death Dis. 2018;9:333 pubmed publisher
    ..We will discuss how defects in MAM signaling may impair neuronal calcium homeostasis, mitochondrial dynamics, ER function, and autophagy, leading ..
  18. Haile Y, Deng X, Ortiz Sandoval C, Tahbaz N, Janowicz A, Lu J, et al. Rab32 connects ER stress to mitochondrial defects in multiple sclerosis. J Neuroinflammation. 2017;14:19 pubmed publisher
    ..understood, the membranous contacts between the ER and mitochondria, called the mitochondria-associated membrane (MAM), could provide a functional link between these two mechanisms...
  19. Prasad M, Walker A, Kaur J, Thomas J, Powell S, Pandey A, et al. Endoplasmic Reticulum Stress Enhances Mitochondrial Metabolic Activity in Mammalian Adrenals and Gonads. Mol Cell Biol. 2016;36:3058-3074 pubmed
    ..by 2-fold by increasing the stability of 3?HSD2 and its association with the mitochondrion-associated ER membrane (MAM) and mitochondrial proteins...
  20. Van Alstyne M, Lotti F, Dal Mas A, Area Gomez E, Pellizzoni L. Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development. Biochem Biophys Res Commun. 2018;506:463-470 pubmed publisher
    ..microscopy to identify Stasimon as an ER-resident protein that localizes at mitochondria-associated ER membranes (MAM), functionally specialized contact sites between ER and mitochondria membranes...
  21. Awaiz A, Rahman F, Hossain M, Yunus R, Khan S, Memon B, et al. Meta-analysis and systematic review of laparoscopic versus open mesh repair for elective incisional hernia. Hernia. 2015;19:449-63 pubmed publisher
    ..Data extraction and critical appraisal were carried out independently by two authors (AA and MAM) using predefined data fields...
  22. Chae S, Kim S, Do Koo Y, Lee J, Kim H, Ahn B, et al. A mitochondrial proteome profile indicative of type 2 diabetes mellitus in skeletal muscles. Exp Mol Med. 2018;50:129 pubmed publisher
    ..the DEPs showed that mitochondrial metabolic processes were downregulated and mitochondria-associated ER membrane (MAM) processes were upregulated...
  23. Kiss T, Krajcs N, Pirger Z, Hernádi L. Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. PLoS ONE. 2014;9:e109538 pubmed publisher
    ..by nAChR selective antagonists such as mytolon, hexamethonium, succinylchloride, d-tubocurarine, hemicholinium, DMDA (decamethonium), methyllycaconitine, α-Bungarotoxin (αBgTx) and α-Conotoxin IMI...
  24. Boulay A, Saubaméa B, Cisternino S, Mignon V, Mazeraud A, Jourdren L, et al. The Sarcoglycan complex is expressed in the cerebrovascular system and is specifically regulated by astroglial Cx30 channels. Front Cell Neurosci. 2015;9:9 pubmed publisher
    ..However, it results in the cerebrovascular fraction, in a strong upregulation of Sgcg encoding γ-Sarcoglycan (γ-SG), a member of the Dystrophin-associated protein complex (DAPC) connecting ..
  25. Tambini M, Pera M, Kanter E, Yang H, Guardia Laguarta C, Holtzman D, et al. ApoE4 upregulates the activity of mitochondria-associated ER membranes. EMBO Rep. 2016;17:27-36 pubmed publisher
    ..showed that there was increased functionality of mitochondria-associated endoplasmic reticulum (ER) membranes (MAM), a subdomain of the ER involved in lipid and cholesterol homeostasis, in presenilin-deficient cells and in ..
  26. Wu Y, Wang J, Yu X, Li D, Han X, Fan L. Sevoflurane ameliorates doxorubicin-induced myocardial injury by affecting the phosphorylation states of proteins in PI3K/Akt/mTOR signaling pathway. Cardiol J. 2017;24:409-418 pubmed publisher
    ..was explored by investigating the phosphorylation states of proteins in phosphatidylinositol 3-kinase (PI3K)/Akt/mam-malian target of rapamycin (mTOR) signaling pathway...
  27. De Vos K, Mórotz G, Stoica R, Tudor E, Lau K, Ackerley S, et al. VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis. Hum Mol Genet. 2012;21:1299-311 pubmed publisher
    ..These are termed mitochondria-associated membranes (MAM)...
  28. Lamers I, Cattaneo D, Chen C, Bertoni R, Van Wijmeersch B, Feys P. Associations of upper limb disability measures on different levels of the International Classification of Functioning, Disability and Health in people with multiple sclerosis. Phys Ther. 2015;95:65-75 pubmed publisher
    ..and pain), activity level (Nine-Hole Peg Test [NHPT], Action Research Arm Test, and Manual Ability Measure-36 [MAM-36]), and participation level (Community Integration Questionnaire)...
  29. Völgyi K, Badics K, Sialana F, Gulyassy P, Udvari E, Kis V, et al. Early Presymptomatic Changes in the Proteome of Mitochondria-Associated Membrane in the APP/PS1 Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2018;55:7839-7857 pubmed publisher
    ..the endoplasmic reticulum (ER) functionally connected to mitochondria, called mitochondria-associated ER membrane (MAM)...
  30. Area Gomez E, de Groof A, Bonilla E, Montesinos J, Tanji K, Boldogh I, et al. A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease. Cell Death Dis. 2018;9:335 pubmed publisher
    ..has been devoted to understanding the contribution of mitochondria-associated endoplasmic reticulum (ER) membranes (MAM) to human pathology in general, and neurodegenerative diseases in particular...
  31. Lopez Crisosto C, Bravo Sagua R, Rodriguez Peña M, Mera C, Castro P, Quest A, et al. ER-to-mitochondria miscommunication and metabolic diseases. Biochim Biophys Acta. 2015;1852:2096-105 pubmed publisher
    ..Numerous studies have demonstrated the importance of MAM in ensuring correct function of both organelles, and recently MAMs have been implicated in the genesis of various ..
  32. Costain W, Tauskela J, Rasquinha I, Comas T, Hewitt M, Marleau V, et al. Pharmacological characterization of emerging synthetic cannabinoids in HEK293T cells and hippocampal neurons. Eur J Pharmacol. 2016;786:234-245 pubmed publisher
    ..ESCs tested were full agonists, with the following rank order of potency: Win 55212-2?5F-PB-22?AB-PINACA?EAM-2201?MAM-2201>JWH-250? PB-22>AKB48 N-(5FP)>AKB-48?STS-135>XLR-11...
  33. Chang C, Lohman J, Cao H, Tan K, Rudolf J, Ma M, et al. Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus. Biochemistry. 2016;55:5142-54 pubmed publisher
  34. Janikiewicz J, Szymański J, Malinska D, Patalas Krawczyk P, Michalska B, Duszyński J, et al. Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics. Cell Death Dis. 2018;9:332 pubmed publisher
    ..contact between mitochondria and the endoplasmic reticulum (ER) are known as mitochondria-associated membranes (MAM) or mitochondria-ER contacts (MERCs), and play an important role in both cell physiology and pathology...
  35. Meincke J, Hewitt M, Batsikadze G, Liebetanz D. Automated TMS hotspot-hunting using a closed loop threshold-based algorithm. Neuroimage. 2016;124:509-517 pubmed publisher
    ..Results were compared to robotic MEP amplitude TMS mapping (MAM) using a 7×7 predefined target grid and suprathreshold intensities and manual hotspot search (MHS)...
  36. dos Santos V, Daniel D, Singh M, do Lago C. Amphetamine and derivatives in natural weight loss pills and dietary supplements by capillary electrophoresis-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1038:19-25 pubmed publisher
    ..mass spectrometry (CE-MS/MS) method for amphetamine (AM), phentermine (PTM), methamphetamine (MAM), methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDMA), and methylenedioxyethylamphetamine (MDEA) ..
  37. Pasternak A, Hamonic G, van Kessel A, Wilson H. Postnatal regulation of MAMDC4 in the porcine intestinal epithelium is influenced by bacterial colonization. Physiol Rep. 2016;4: pubmed
    The MAM domain-containing 4 (MAMDC4) protein is associated with the unique endocytotic mechanism observed in the intestine of mammals during the immediate postnatal period...
  38. Breyner N, Michon C, de Sousa C, Vilas Boas P, Chain F, Azevedo V, et al. Microbial Anti-Inflammatory Molecule (MAM) from Faecalibacterium prausnitzii Shows a Protective Effect on DNBS and DSS-Induced Colitis Model in Mice through Inhibition of NF-?B Pathway. Front Microbiol. 2017;8:114 pubmed publisher
    ..prausnitzii supernatant, all belonging to a protein called Microbial Anti-inflammatory Molecule (MAM)...
  39. Matsumoto T, Uchiumi T, Monji K, Yagi M, Setoyama D, Amamoto R, et al. Doxycycline induces apoptosis via ER stress selectively to cells with a cancer stem cell-like properties: importance of stem cell plasticity. Oncogenesis. 2017;6:397 pubmed publisher
    ..showed increased contact between mitochondria and mitochondrial associated-endoplasmic reticulum (ER) membranes (MAM)...
  40. Magalhães T, Cravo S, Silva D, Dinis Oliveira R, Afonso C, Lourdes Bastos M, et al. Quantification of Methadone and Main Metabolites in Nails. J Anal Toxicol. 2017;: pubmed publisher
    ..aimed to implement an analytical method for the simultaneous detection of morphine (MORF), 6-monoacetylmorphine (6-MAM), methadone (MET), 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-..
  41. Lohße A, Kolinko I, Raschdorf O, Uebe R, Borg S, Brachmann A, et al. Overproduction of Magnetosomes by Genomic Amplification of Biosynthesis-Related Gene Clusters in a Magnetotactic Bacterium. Appl Environ Microbiol. 2016;82:3032-3041 pubmed publisher
    ..In this study, we found that the size and number of magnetosomes within the cell are controlled by many different Mam and Mms proteins...
  42. Leal N, Schreiner B, Pinho C, Filadi R, Wiehager B, Karlstrom H, et al. Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid ?-peptide production. J Cell Mol Med. 2016;20:1686-95 pubmed publisher
    ..Such contacts are formed between mitochondria-associated ER membranes (MAM), specialized subregions of ER, and the outer mitochondrial membrane (OMM)...
  43. Kong T, Kim J, Kwon S, Cheong J, Kim H, In M, et al. Inhibition of cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferases by MAM-2201 in human liver microsomes. Arch Pharm Res. 2017;40:727-735 pubmed publisher
    b>MAM-2201, a synthetic cannabinoid, is a potent agonist of the cannabinoid receptors and is increasingly used as an illicit recreational drug...
  44. Zhang Z, Meszaros G, He W, Xu Y, de Fatima Magliarelli H, Mailly L, et al. Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med. 2017;214:2671-2693 pubmed publisher
    ..that NLRP3 is recruited to mitochondria-associated endoplasmic reticulum membranes (MAMs) and is activated by MAM-derived effectors...
  45. Area Gomez E, Schon E. Alzheimer Disease. Adv Exp Med Biol. 2017;997:149-156 pubmed publisher
    ..are associated with a subdomain of the endoplasmic reticulum (ER) called mitochondria-associated ER membranes (MAM)...
  46. Gomez Suaga P, Bravo San Pedro J, Gonzalez Polo R, Fuentes J, Niso Santano M. ER-mitochondria signaling in Parkinson's disease. Cell Death Dis. 2018;9:337 pubmed publisher
    ..with a specialized domain of the endoplasmic reticulum (ER), known as the mitochondria-associated membrane (MAM). This association constitutes a key signaling hub to regulate several fundamental cellular processes...
  47. Lagrone L, Trehan I, Meuli G, Wang R, Thakwalakwa C, Maleta K, et al. A novel fortified blended flour, corn-soy blend "plus-plus," is not inferior to lipid-based ready-to-use supplementary foods for the treatment of moderate acute malnutrition in Malawian children. Am J Clin Nutr. 2012;95:212-9 pubmed publisher
    Children with moderate acute malnutrition (MAM) are often treated with fortified blended flours, most commonly a corn-soy blend (CSB)...
  48. Arolas J, Goulas T, Pomerantsev A, Leppla S, Gomis Rüth F. Structural Basis for Latency and Function of Immune Inhibitor A Metallopeptidase, a Modulator of the Bacillus anthracis Secretome. Structure. 2016;24:25-36 pubmed publisher
    ..structure featuring a pro-peptide, a catalytic domain, a domain reminiscent of viral envelope glycoproteins, and a MAM domain grafted into the latter...
  49. Flood J, Khaliq T, Bishop K, Griggs D. The New Substance Abuse and Mental Health Services Administration Oral Fluid Cutoffs for Cocaine and Heroin-Related Analytes Applied to an Addiction Medicine Setting: Important, Unanticipated Findings with LC-MS/MS. Clin Chem. 2016;62:773-80 pubmed publisher
    ..all findings from a 22-month collection period for COC, benzoylecgonine (BZE), codeine (COD), 6-acetylmorphine (MAM), and morphine (MOR)...
  50. Wu W, Lin C, Wu K, Jiang L, Wang X, Li W, et al. FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions. EMBO J. 2016;35:1368-84 pubmed publisher
    ..The ER-mitochondrial contact site (MAM) is essential for fission of mitochondria prior to engulfment, and the outer mitochondrial membrane protein FUNDC1 ..
  51. Heydemann A. Severe murine limb-girdle muscular dystrophy type 2C pathology is diminished by FTY720 treatment. Muscle Nerve. 2017;56:486-494 pubmed publisher
    ..This study examined the efficacy of the sphingosine-1-phosphate receptor modulator FTY720 in treating Sgcg-/- DBA2/J, a severe mouse model of LGMD-2C...
  52. Blandin G, Marchand S, Charton K, Daniele N, Gicquel E, Boucheteil J, et al. A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. Skelet Muscle. 2013;3:3 pubmed publisher
    ..The data also suggest the existence of functional links between LGMD2B/dysferlin and gene regulation, between LGMD2C/?-sarcoglycan and energy control and between LGMD2G/telethonin and maintenance of genome integrity...
  53. Goldstein J, Bogdanovich S, Beiriger A, Wren L, Rossi A, Gao Q, et al. Excess SMAD signaling contributes to heart and muscle dysfunction in muscular dystrophy. Hum Mol Genet. 2014;23:6722-31 pubmed publisher
    ..Muscle lacking the dystrophin-associated protein γ-sarcoglycan (Sgcg null) was subjected to a lengthening protocol to produce maximal muscle injury, which produced rapid accumulation ..
  54. Bradley R, Marvyn P, Aristizabal Henao J, Mardian E, George S, Aucoin M, et al. Acylglycerophosphate acyltransferase 4 (AGPAT4) is a mitochondrial lysophosphatidic acid acyltransferase that regulates brain phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol levels. Biochim Biophys Acta. 2015;1851:1566-76 pubmed publisher
    ..e. mam)...
  55. Bhide G, Fernandes N, Colley K. Sequence Requirements for Neuropilin-2 Recognition by ST8SiaIV and Polysialylation of Its O-Glycans. J Biol Chem. 2016;291:9444-57 pubmed publisher
    ..Evaluation of the soluble chimeric proteins demonstrated that the meprin A5 antigen-μ tyrosine phosphatase (MAM) domain and the O-glycan-containing linker region of neuropilin-2 are necessary and sufficient for its ..
  56. O Reilly K, Perica M, Fenton A. Memory deficits with intact cognitive control in the methylazoxymethanol acetate (MAM) exposure model of neurodevelopmental insult. Neurobiol Learn Mem. 2016;134 Pt B:294-303 pubmed publisher
    ..Rats exposed to methylazoxymethanol acetate (MAM) at gestational day 17 display morphological, physiological and behavioral abnormalities relevant to schizophrenia...
  57. Xiao F, Zhang J, Zhang C, An W. Hepatic stimulator substance inhibits calcium overflow through the mitochondria-associated membrane compartment during nonalcoholic steatohepatitis. Lab Invest. 2017;97:289-301 pubmed publisher
    ..and mitochondrial membranes overlap by 15-20%, a region referred to as the 'mitochondria-associated ER membrane' (MAM)...
  58. Neary J, Perez S, Peterson K, Lodge D, Carless M. Comparative analysis of MBD-seq and MeDIP-seq and estimation of gene expression changes in a rodent model of schizophrenia. Genomics. 2017;109:204-213 pubmed publisher
    ..MBD-seq and MeDIP-seq) in a rodent model of schizophrenia, induced by in utero methylazoxymethanol acetate (MAM) exposure. We also examined related gene expression changes using a pooled sample approach...
  59. Wei Z, Lihua L, Qingqing W. [Effects of myeloid specific deficiency of FBXW7 on lung metastasis of murine melanoma]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2017;46:111-117 pubmed
    ..The proportion of metastasis-associated macrophages (MAM) in the lungs of Lysm+FBXW7 f/f mice was reduced [(23.15±7.59)% vs (13.13±2...
  60. Sánchez Paniagua López M, Redondo Gómez E, López Ruiz B. Electrochemical enzyme biosensors based on calcium phosphate materials for tyramine detection in food samples. Talanta. 2017;175:209-216 pubmed publisher
    ..8 × 10-7 to 1.6 × 10-5, sensitivity 1.50 × 103mAM-1 cm-2, detection limit, 4.85 × 10-8M and a response time, 6s were obtained...
  61. Zhang M, Zhang C, Pan L, Gong S, Cui W, Yuan H, et al. Meiotic arrest with roscovitine and follicular fluid improves cytoplasmic maturation of porcine oocytes by promoting chromatin de-condensation and gene transcription. Sci Rep. 2017;7:11574 pubmed publisher
    ..Although great efforts were made to accomplish better cytoplasmic maturation by meiotic arrest maintenance (MAM) before in vitro maturation (IVM), limited progress has been achieved in various species...
  62. Williams A, Hayashi T, Wolozny D, Yin B, Su T, Betenbaugh M, et al. The non-apoptotic action of Bcl-xL: regulating Ca(2+) signaling and bioenergetics at the ER-mitochondrion interface. J Bioenerg Biomembr. 2016;48:211-25 pubmed publisher
    ..In this study, a portion of Bcl-xL was detected at the ER-mitochondrion interface or MAM (mitochondria-associated ER membrane) in association with type 3 inositol 1,4,5-trisphosphate receptors (IP3R3); an ..
  63. Yelland T, Djordjevic S. Crystal Structure of the Neuropilin-1 MAM Domain: Completing the Neuropilin-1 Ectodomain Picture. Structure. 2016;24:2008-2015 pubmed publisher
    ..The MAM domain of NRP, which has previously been implicated in receptor multimerization, was the only portion of the ..
  64. Dong L, Wang J, Liu P, Yang Y, Feng J, Han Y. Faecal and mucosal microbiota in patients with functional gastrointestinal disorders: Correlation with toll-like receptor 2/toll-like receptor 4 expression. World J Gastroenterol. 2017;23:6665-6673 pubmed publisher
    To investigate the intestinal luminal microbiota (LM) and mucosa-associated microbiota (MAM) in Chinese patients with functional gastrointestinal disorders (FGIDs) and examine the association between these communities and the expression ..
  65. Ratajczak P, Kus K, Murawiecka P, Słodzińska I, Giermaziak W, Nowakowska E. Biochemical and cognitive impairments observed in animal models of schizophrenia induced by prenatal stress paradigm or methylazoxymethanol acetate administration. Acta Neurobiol Exp (Wars). 2015;75:314-25 pubmed
    ..The effect of prenatal stress (stress paradigm between 14 and 21 day of gestation) and methylazoxymethanol acetate (MAM) administration (17 day of gestation) to the female Wistar rats were studied on the male offspring in the Morris ..
  66. Narayanan N, Gupta S, Gajbhiye V, Manjaiah K. Optimization of isotherm models for pesticide sorption on biopolymer-nanoclay composite by error analysis. Chemosphere. 2017;173:502-511 pubmed publisher
    ..organoclay (nano montmorillonite modified with 35-45 wt % dimethyl dialkyl (C14-C18) amine (DMDA)) composite was prepared by solution intercalation method...
  67. Kerkhofs M, Giorgi C, Marchi S, Seitaj B, Parys J, Pinton P, et al. Alterations in Ca2+ Signalling via ER-Mitochondria Contact Site Remodelling in Cancer. Adv Exp Med Biol. 2017;997:225-254 pubmed publisher
    ..In this book chapter, we will provide an overview of the role of the MAMs in cell function and how alterations in the MAM composition contribute to oncogenic features and behaviours.
  68. Ben Othmane K, Speer M, Stauffer J, Blel S, Middleton L, Ben Hamida C, et al. Evidence for linkage disequilibrium in chromosome 13-linked Duchenne-like muscular dystrophy (LGMD2C). Am J Hum Genet. 1995;57:732-4 pubmed
  69. Guyon J, Kudryashova E, Potts A, Dalkilic I, Brosius M, Thompson T, et al. Calpain 3 cleaves filamin C and regulates its ability to interact with gamma- and delta-sarcoglycans. Muscle Nerve. 2003;28:472-83 pubmed
    ..Thus, calpain-mediated remodeling of cytoskeletal-membrane interactions, such as those that occur during myoblast fusion and muscle repair, may involve regulation of FLNC-sarcoglycan interactions. ..
  70. Fryer C, White J, Jones K. Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol Cell. 2004;16:509-20 pubmed
    Notch signaling releases the Notch receptor intracellular domain (ICD), which complexes with CBF1 and Mastermind (MAM) to activate responsive genes...
  71. Khadilkar S, Singh R, Hegde M, Urtizberea A, Love D, Chong B. Spectrum of mutations in sarcoglycan genes in the Mumbai region of western India: high prevalence of 525del T. Neurol India. 2009;57:406-10 pubmed publisher
    ..The clinical profile of various mutations was indistinguishable from each other. Gamma SG mutations were most common, seen in 8 patients, followed by delta SG mutation in 5 patients and alpha mutation in ..
  72. Smith E, Koller D, Panganiban C, Szelinger S, Zhang P, Badner J, et al. Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes. PLoS Genet. 2011;7:e1002134 pubmed publisher
  73. Moramarco S, Amerio G, Ciarlantini C, Chipoma J, Simpungwe M, Nielsen Saines K, et al. Community-Based Management of Child Malnutrition in Zambia: HIV/AIDS Infection and Other Risk Factors on Child Survival. Int J Environ Res Public Health. 2016;13: pubmed publisher
    ..feeding programs (SFPs) are effective in the community-based treatment of moderate acute malnutrition (MAM) and prevention of severe acute malnutrition (SAM); (2) METHODS: A retrospective study was conducted on a sample of ..
  74. Dalichaouche I, Sifi Y, Roudaut C, Sifi K, Hamri A, Rouabah L, et al. ?-sarcoglycan and dystrophin mutation spectrum in an Algerian cohort. Muscle Nerve. 2017;56:129-135 pubmed publisher
    ..define the genetic basis of the diseases in these families, we undertook a series of analyses of the ?-sarcoglycan (SGCG) and DMD genes. Fifteen families were shown to carry SGCG variants...
  75. Tubbs E, Rieusset J. Metabolic signaling functions of ER-mitochondria contact sites: role in metabolic diseases. J Mol Endocrinol. 2017;58:R87-R106 pubmed publisher
    ..and the determination of cell fate, ER-mitochondria contact sites, defined as mitochondria-associated membranes (MAM), start to emerge as an important signaling hub that integrates nutrient and hormonal stimuli and adapts cellular ..
  76. Houngbé F, Tonguet Papucci A, Altare C, Ait Aissa M, Huneau J, Huybregts L, et al. Unconditional Cash Transfers Do Not Prevent Children's Undernutrition in the Moderate Acute Malnutrition Out (MAM'Out) Cluster-Randomized Controlled Trial in Rural Burkina Faso. J Nutr. 2017;147:1410-1417 pubmed publisher
    ..Cash transfers combined with complementary interventions targeted to child nutrition and health should be investigated further. This trial was registered at clinicaltrials.gov as NCT01866124. ..
  77. Mar A, Nilsson S, Gamallo Lana B, Lei M, Dourado T, Alsiö J, et al. MAM-E17 rat model impairments on a novel continuous performance task: effects of potential cognitive enhancing drugs. Psychopharmacology (Berl). 2017;234:2837-2857 pubmed publisher
    ..neural and behavioral features relevant to schizophrenia (gestational day 17 methylazoxymethanol acetate treatment (MAM-E17)) on a novel test of attention and executive function, and examined the impact of putative nootropic drugs...
  78. Herrera Cruz M, Simmen T. Over Six Decades of Discovery and Characterization of the Architecture at Mitochondria-Associated Membranes (MAMs). Adv Exp Med Biol. 2017;997:13-31 pubmed publisher
    ..1950s and the first characterization of their function (and coining of the term mitochondria-associated membrane, MAM) in 1990...
  79. Li W, Webster K, LeBlanc M, Tian H. Secretogranin III: a diabetic retinopathy-selective angiogenic factor. Cell Mol Life Sci. 2018;75:635-647 pubmed publisher
    Secretogranin III (Scg3) is a member of the granin protein family that regulates the biogenesis of secretory granules. Scg3 was recently discovered as an angiogenic factor, expanding its functional role to extrinsic regulation...
  80. Xu Z, Liu C, Hang J, Gao B, Hu J. Rituximab effectively reverses Tyrosine kinase inhibitors (TKIs) resistance through inhibiting the accumulation of rictor on mitochondria-associated ER-membrane (MAM). Cancer Biomark. 2017;20:581-588 pubmed publisher
    ..western blotting and immunofluorescence assays demonstrated that the accumulation of rictor was also decreased on MAM. Thus, all these results suggested that EGFR-TKIs combined with CD20 mono-antibody significantly decrease the cell ..
  81. Rico Yuste A, Walravens J, Urraca J, Abou Hany R, Descalzo A, Orellana G, et al. Analysis of alternariol and alternariol monomethyl ether in foodstuffs by molecularly imprinted solid-phase extraction and ultra-high-performance liquid chromatography tandem mass spectrometry. Food Chem. 2018;243:357-364 pubmed publisher
    ..The polymer was prepared using 4-vinylpiridine (VIPY) and methacrylamide (MAM) as functional monomers, ethylene glycol dimethacrylate (EDMA) as cross-linker and 3,8,9-trihydroxy-6H-dibenzo[b,d]..
  82. Tang F, Pacheco M, Chen P, Liang D, Li W. Secretogranin III promotes angiogenesis through MEK/ERK signaling pathway. Biochem Biophys Res Commun. 2018;495:781-786 pubmed publisher
    Secretogranin III (Scg3) was recently discovered as the first highly diabetic retinopathy-associated angiogenic factor, and its neutralizing antibody alleviated the disease with high efficacy in diabetic mice...
  83. Jorde L, Watkins W, Viskochil D, O Connell P, Ward K. Linkage disequilibrium in the neurofibromatosis 1 (NF1) region: implications for gene mapping. Am J Hum Genet. 1993;53:1038-50 pubmed
    ..These are discussed, and guidelines for linkage disequilibrium studies are suggested. ..
  84. Nowak K, Walsh P, Jacob R, Johnsen R, Peverall J, McNally E, et al. Severe gamma-sarcoglycanopathy caused by a novel missense mutation and a large deletion. Neuromuscul Disord. 2000;10:100-7 pubmed
    ..The fact that the affected individuals in the current and Gypsy families are gamma-sarcoglycan negative may indicate that codons 69 and 283 are important in gamma-sarcoglycan function. ..
  85. Todorova A, Tournev I, Ninova N, Georgieva V, Kremensky I. Screening for C283Y gamma-sarcoglycan mutation in a high-risk group of Bulgarian Gypsies: evidence for a geographical localization and a non-random distribution among Gypsy subgroups. Community Genet. 2002;5:217-21 pubmed
    Limb-girdle muscular dystrophy type 2C (LGMD2C) is an autosomal recessive disorder caused by mutations in the gamma-sarcoglycan gene. A 'private' Gypsy C283Y mutation was detected in this gene...
  86. Dicapua D, Patwa H. Puerto Rican founder mutation G787A in the SGCG gene: a case report of 2 siblings with LGMD 2C. J Clin Neuromuscul Dis. 2014;15:105-7 pubmed publisher
    We describe 2 siblings who are homozygous for the G787A mutation in the ?-sarcoglycan gene (SGCG), who presented with a severe childhood onset limb-girdle muscular dystrophy, and share a similar clinical phenotype and disease course ..
  87. Cheng M, Chen Y, Zou D, Shen G, Bian G, Shen G, et al. The clinical utility of circulating tumor cells in breast cancer patients: detection by a quantitative assay of h-MAM gene expression. Int J Biol Markers. 2014;29:e268-78 pubmed publisher
    ..Quantitative real-time RT-PCR was used to determine h-MAM, BCSG1, CK19, and c-erbB2 mRNA levels in peripheral blood (PB) of breast cancer patients...
  88. Kvello A, Andersen J, Øiestad E, Mørland J, Bogen I. Pharmacological Effects of a Monoclonal Antibody against 6-Monoacetylmorphine upon Heroin-Induced Locomotor Activity and Pharmacokinetics in Mice. J Pharmacol Exp Ther. 2016;358:181-9 pubmed publisher
    ..Previous studies have shown that heroin's first metabolite, 6-monoacetylmorphine (6-MAM), is the main mediator of acute heroin effects...
  89. Doghman Bouguerra M, Lalli E. The ER-mitochondria couple: In life and death from steroidogenesis to tumorigenesis. Mol Cell Endocrinol. 2017;441:176-184 pubmed publisher
    ..Moreover, our recent characterization of new MAM resident proteins in adrenocortical cells extends the function of MAM in the mechanism of resistance of cancer ..
  90. Mohamed H, Obaid M, Sayed E, Liu Y, Lee J, Park M, et al. Electricity generation from real industrial wastewater using a single-chamber air cathode microbial fuel cell with an activated carbon anode. Bioprocess Biosyst Eng. 2017;40:1151-1161 pubmed publisher
    ..Initial tests of a single air-cathode MFC display a current density of 1792 mAm-2, which is approximately four times greater than the maximum value of the other anode materials...
  91. Yang M, Yang H, Li J, Sun J, Bi W, Niu G, et al. Scavenger receptor C promotes bacterial clearance in kuruma shrimp Marsupenaeus japonicus by enhancing hemocyte phagocytosis and AMP expression. Fish Shellfish Immunol. 2017;67:254-262 pubmed publisher
    ..The recombinant extracellular domains (MAM and CCP domains) of MjSRC have the ability of binding different bacteria and glycans in vitro...
  92. Tasca G, Monforte M, Diaz Manera J, Brisca G, Semplicini C, D Amico A, et al. MRI in sarcoglycanopathies: a large international cohort study. J Neurol Neurosurg Psychiatry. 2018;89:72-77 pubmed publisher
    ..on muscle MRI in a large cohort of patients with sarcoglycanopathies, which are limb-girdle muscular dystrophies (LGMD2C-2F) caused by mutations in one of the four genes coding for muscle sarcoglycans...