SGCB

Summary

Gene Symbol: SGCB
Description: sarcoglycan beta
Alias: A3b, LGMD2E, SGC, beta-sarcoglycan, 43 kDa dystrophin-associated glycoprotein, 43DAG, beta-SG, beta-sarcoglycan(43kD dystrophin-associated glycoprotein), limb girdle muscular dystrophy 2E (non-linked families), sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
Species: human
Products:     SGCB

Top Publications

  1. Yoshida M, Ozawa E. Glycoprotein complex anchoring dystrophin to sarcolemma. J Biochem. 1990;108:748-52 pubmed
    ..The doublet of A3 was subdivided into A3a and A3b in the decreasing order of molecular weight...
  2. Bonnemann C, Modi R, Noguchi S, Mizuno Y, Yoshida M, Gussoni E, et al. Beta-sarcoglycan (A3b) mutations cause autosomal recessive muscular dystrophy with loss of the sarcoglycan complex. Nat Genet. 1995;11:266-73 pubmed
    ..Here we report the isolation of cDNAs encoding the 43 kD sarcoglycan protein beta-sarcoglycan (A3b) and the localization of the human gene to chromosome 4q12...
  3. Bonnemann C, Passos Bueno M, McNally E, Vainzof M, de Sá Moreira E, Marie S, et al. Genomic screening for beta-sarcoglycan gene mutations: missense mutations may cause severe limb-girdle muscular dystrophy type 2E (LGMD 2E). Hum Mol Genet. 1996;5:1953-61 pubmed
    ..All three missense mutations occurred in exon 3, coding for the immediate extracellular domain. Complete absence for all three of the known sarcoglycans was noted by immunohistochemistry on muscle biopsy sections of the patients. ..
  4. Duclos F, Broux O, Bourg N, Straub V, Feldman G, Sunada Y, et al. Beta-sarcoglycan: genomic analysis and identification of a novel missense mutation in the LGMD2E Amish isolate. Neuromuscul Disord. 1998;8:30-8 pubmed
    ..A missense mutation (T151R) in the beta-sarcoglycan gene on chromosome 4q12 has been shown to cause a mild form of LGMD2E in 11 families from a Southern Indiana Amish community sharing a common haplotype...
  5. Bonnemann C, Wong J, Ben Hamida C, Hamida M, Hentati F, Kunkel L. LGMD 2E in Tunisia is caused by a homozygous missense mutation in beta-sarcoglycan exon 3. Neuromuscul Disord. 1998;8:193-7 pubmed
  6. McCarty M. Supplementation with Phycocyanobilin, Citrulline, Taurine, and Supranutritional Doses of Folic Acid and Biotin-Potential for Preventing or Slowing the Progression of Diabetic Complications. Healthcare (Basel). 2017;5: pubmed publisher
    ..dose biotin has the potential to "pinch hit" for diminished NO by direct activation of soluble guanylate cyclase (sGC)...
  7. Zhuo W, Liu Y, Li S, Guo D, Sun Q, Jin J, et al. Long Noncoding RNA GMAN, Up-regulated in Gastric Cancer Tissues, Is Associated With Metastasis in Patients and Promotes Translation of Ephrin A1 by Competitively Binding GMAN-AS. Gastroenterology. 2019;156:676-691.e11 pubmed publisher
    ..RNA levels were knocked down or knocked out in BGC-823, SGC-7901, and MKN45 cell lines using small interfering or short hairpin RNAs or clustered regularly interspaced short ..
  8. Mokhtar D, Hussein M, Hassan A. Melatonin Elicits Stimulatory Action on the Adrenal Gland of Soay Ram: Morphometrical, Immunohistochemical, and Ultrastructural Study. Microsc Microanal. 2017;:1-16 pubmed publisher
    ..The most interesting feature in this study is the presence of small granule chromaffin cells (SGC) and telocytes (TCs) for the first time in the adrenal glands of sheep...
  9. Suriyonplengsaeng C, Dejthevaporn C, Khongkhatithum C, Sanpapant S, Tubthong N, Pinpradap K, et al. Immunohistochemistry of sarcolemmal membrane-associated proteins in formalin-fixed and paraffin-embedded skeletal muscle tissue: a promising tool for the diagnostic evaluation of common muscular dystrophies. Diagn Pathol. 2017;12:19 pubmed publisher
    ..a valuable tool for the diagnosis of some muscular dystrophies, dystrophinopathies, sarcoglycanopathies (LGMD2D, LGMD2E, and LGMD2C), and dysferlinopathy, especially in situations where the analysis of fresh frozen muscle samples is ..

More Information

Publications150 found, 100 shown here

  1. Ryter S, Ma K, Choi A. Carbon Monoxide in Lung Cell Physiology and Disease. Am J Physiol Cell Physiol. 2017;:ajpcell.00022.2017 pubmed publisher
    ..CO, which binds primarily to heme iron, may activate the hemoprotein guanylate cyclase (sGC), although with lower potency than NO...
  2. Hong H, Jiang L, Lin Y, He C, Zhu G, Du Q, et al. TNF-alpha promotes lymphangiogenesis and lymphatic metastasis of gallbladder cancer through the ERK1/2/AP-1/VEGF-D pathway. BMC Cancer. 2016;16:240 pubmed publisher
    ..The VEGF-D mRNA and protein levels after treatment with exogenous TNF-? in NOZ, GBC-SD and SGC-996 cell lines were measured by real-time PCR and ELISA...
  3. Su Y. Regulation of endothelial nitric oxide synthase activity by protein-protein interaction. Curr Pharm Des. 2014;20:3514-20 pubmed
    ..CAT-1), argininosuccinate synthase (ASS), argininosuccinate lyase (ASL), and soluble guanylate cyclase (sGC) facilitate directed delivery of substrate (L-arginine) to eNOS and optimizing NO production and NO action on its ..
  4. Fouda M, El Gowelli H, El Gowilly S, El Mas M. Hemin blunts the depressant effect of chronic nicotine on reflex tachycardia via activation of central NOS/PI3K pathway in female rats. Pharmacol Rep. 2018;70:455-462 pubmed publisher
    ..whether products of nitric oxide synthase (NOS) and/or heme oxygenase (HO) and related soluble guanylate cyclase (sGC)/phosphatidylinositol 3-kinase (PI3K)/mitogen-activated protein kinases (MAPKs) signaling mediate the E2-..
  5. Wang M, Cai J, Huang F, Zhu M, Zhang Q, Yang T, et al. Pre-treatment of human umbilical cord-derived mesenchymal stem cells with interleukin-6 abolishes their growth-promoting effect on gastric cancer cells. Int J Mol Med. 2015;35:367-75 pubmed publisher
    ..MNNG)‑transformed GES-1 gastric epithelial cells or SGC-7901 gastric cancer cells...
  6. Ulbrich F, Hagmann C, Buerkle H, Romão C, Schallner N, Goebel U, et al. The Carbon monoxide releasing molecule ALF-186 mediates anti-inflammatory and neuroprotective effects via the soluble guanylate cyclase ß1 in rats' retinal ganglion cells after ischemia and reperfusion injury. J Neuroinflammation. 2017;14:130 pubmed publisher
    ..analyze the effects of the CORM ALF-186 on neuro-inflammation and hypothesized that the soluble guanylate cyclase (sGC) is playing a decisive role. Retinal ischemia-reperfusion injury was performed for 60 min in Sprague-Dawley rats...
  7. Potje S, Troiano J, Graton M, Ximenes V, Nakamune A, Antoniali C. Hypotensive and vasorelaxant effect of Diapocynin in normotensive rats. Free Radic Biol Med. 2017;106:148-157 pubmed publisher
    ..The relaxation induced by apocynin or diapocynin involves sGC and potassium channels in vascular smooth muscle cells and NOS participates of relaxation induced by apocynin or ..
  8. Magierowski M, Magierowska K, Hubalewska Mazgaj M, Adamski J, Bakalarz D, Sliwowski Z, et al. Interaction between endogenous carbon monoxide and hydrogen sulfide in the mechanism of gastroprotection against acute aspirin-induced gastric damage. Pharmacol Res. 2016;114:235-250 pubmed publisher
    ..to H2S, CO ameliorates hypoxia, regulates Nrf-2 expression but similarly to H2S acts on sGC-dependent manner to restore gastric microcirculation and exhibit anti-inflammatory activity in gastric mucosa ..
  9. Dias L, Rodrigues M, Inoue B, Rodrigues R, Rennó A, de Souza V, et al. Pharmacological analysis of hemodynamic responses to Lachesis muta (South American bushmaster) snake venom in anesthetized rats. Toxicon. 2016;123:25-44 pubmed publisher
    ..the recovery phase and resulted in rapid death; a similar effect was observed with the soluble guanylate cyclase (sGC) inhibitor ODQ...
  10. Chen C, Guo C, Gao J, Shi K, Cheng J, Zhang J, et al. Vasorelaxant and antihypertensive effects of Tianshu Capsule on rats: An in vitro and in vivo approach. Biomed Pharmacother. 2019;111:188-197 pubmed publisher
    ..The NO/sGC/cGMP pathway, ATP-sensitive K+ channels, Ca2+-activated K+ channels, inhibition of ..
  11. Zhou X, Zhang F, Ying C, Chen J, Chen L, Dong J, et al. Inhibition of iNOS alleviates cognitive deficits and depression in diabetic mice through downregulating the NO/sGC/cGMP/PKG signal pathway. Behav Brain Res. 2017;322:70-82 pubmed publisher
    ..the inflammatory factor inducible nitric oxide synthase (iNOS) and the nitric oxide (NO)/soluble guanylyl cyclases (sGC)/cyclic guanosine monophosphate (cGMP)/protein kinase G (PKG) pathway, play key roles in cognitive deficits and ..
  12. Zhou J, Wang W, Xie Y, Zhao Y, Chen X, Xu W, et al. Proteomics-Based Identification and Analysis of Proteins Associated with Helicobacter pylori in Gastric Cancer. PLoS ONE. 2016;11:e0146521 pubmed publisher
    ..pylori virulence, we established three cell lines by infecting the gastric cancer cell lines SGC-7901 and AGS with cagA+ H. pylori and transfecting SGC-7901 with a vector carrying the full-length cagA gene...
  13. Porto H, Grando M, Ramalho L, Valadares M, Bendhack L, Batista A, et al. Exposure to acetaminophen impairs vasodilation, increases oxidative stress and changes arterial morphology of rats. Arch Toxicol. 2019;: pubmed publisher
    ..eNOS and sGC protein expression remained unchanged and were at similar levels as controls...
  14. Nagasu H, Satoh M, Kidokoro K, Nishi Y, Channon K, Sasaki T, et al. Endothelial dysfunction promotes the transition from compensatory renal hypertrophy to kidney injury after unilateral nephrectomy in mice. Am J Physiol Renal Physiol. 2012;302:F1402-8 pubmed publisher
    ..We hypothesized that the endothelial nitric oxide synthase (eNOS) [soluble guanylate cyclase (sGC)] protein kinase G (PKG) pathway plays an important role in compensatory renal hypertrophy after unilateral ..
  15. Tasca G, Monforte M, Diaz Manera J, Brisca G, Semplicini C, D Amico A, et al. MRI in sarcoglycanopathies: a large international cohort study. J Neurol Neurosurg Psychiatry. 2018;89:72-77 pubmed publisher
    ..Scans from 69 patients were examined (38 LGMD2D, 18 LGMD2C, 12 LGMD2E and 1 LGMD2F)...
  16. Wu J, Kao L, Wu B, Dai Z, Wang Y, Chai C, et al. Buffered l-ascorbic acid, alone or bound to KMUP-1 or sildenafil, reduces vascular endothelium growth factor and restores endothelium nitric oxide synthase in hypoxic pulmonary artery. Kaohsiung J Med Sci. 2015;31:241-54 pubmed publisher
    ..Pulmonary artery blood pressure, and VEGF, Rho kinase II (ROCK II), eNOS, soluble guanylate cyclase (sGC-α), and protein kinase G expression in lung tissues were measured to link PAH and right ventricular hypertrophy...
  17. Yam M, Tan C, Shibao R. Vasorelaxant effect of sinensetin via the NO/sGC/cGMP pathway and potassium and calcium channels. Hypertens Res. 2018;: pubmed publisher
    ..The present study demonstrates the vasorelaxant effect of sinensetin, which involves the NO/sGC/cGMP and indomethacin pathways, calcium and potassium channels, and muscarinic and beta-adrenergic receptors.
  18. Kessler T, Wobst J, Wolf B, Eckhold J, Vilne B, Hollstein R, et al. Functional Characterization of the GUCY1A3 Coronary Artery Disease Risk Locus. Circulation. 2017;136:476-489 pubmed publisher
    ..The locus encompasses GUCY1A3, which encodes the ?1 subunit of the soluble guanylyl cyclase (sGC), a key enzyme in the nitric oxide/cGMP signaling pathway...
  19. Tan C, Ch ng Y, Loh Y, Zaini Asmawi M, Ahmad M, Yam M. Vasorelaxation effect of Glycyrrhizae uralensis through the endothelium-dependent Pathway. J Ethnopharmacol. 2017;199:149-160 pubmed publisher
    ..EFG was also found to be effective in reducing Ca2+ release from sarcoplasmic reticulum and the blocking of calcium channels. The results obtained suggest that EFG is involved in the NO/sGC/cGMP pathway.
  20. Kraisoon A, Redmer D, Bass C, Navanukraw C, Dorsam S, Valkov V, et al. Corpora lutea in superovulated ewes fed different planes of nutrition. Domest Anim Endocrinol. 2018;62:16-23 pubmed publisher
    ..proliferation; (4) vascularity; (5) expression of endothelial nitric oxide (eNOS) and soluble guanylate cyclase (sGC) proteins; and (6) luteal and serum progesterone (P4) concentration in control (C), overfed (O), and underfed (U) ..
  21. Takushima S, Nishi Y, Nonoshita A, Mifune H, Hirata R, Tanaka E, et al. Changes in the nitric oxide-soluble guanylate cyclase system and natriuretic peptide receptor system in placentas of pregnant Dahl salt-sensitive rats. J Obstet Gynaecol Res. 2015;41:540-50 pubmed publisher
    ..The present study attempted to assess the changes and the interactions of the NOS-NO-sGC-cGMP and NP-NPR-cGMP systems in the hypertensive placenta using Dahl-S rats as an animal model of superimposed pre-..
  22. Wang X, Wang J, Luo H, Chen C, Pei F, Cai Y, et al. Prenatal lipopolysaccharide exposure causes mesenteric vascular dysfunction through the nitric oxide and cyclic guanosine monophosphate pathway in offspring. Free Radic Biol Med. 2015;86:322-30 pubmed publisher
    ..The functional results were accompanied by a reduction in the expressions of eNOS and soluble guanylate cyclase (sGC) and production of NO and cGMP in arteries from offspring of LPS-treated dams...
  23. Li X, Xie H, Chen Y, Lang M, Chen Y, Shi L. Silkworm Pupa Protein Hydrolysate Induces Mitochondria-Dependent Apoptosis and S Phase Cell Cycle Arrest in Human Gastric Cancer SGC-7901 Cells. Int J Mol Sci. 2018;19: pubmed publisher
    ..can specifically inhibit the proliferation and provoke abnormal morphologic features of human gastric cancer cells SGC-7901 in a dose- and time-dependent manner...
  24. Chiesa J, Baidanoff F, Golombek D. Don't just say no: Differential pathways and pharmacological responses to diverse nitric oxide donors. Biochem Pharmacol. 2018;156:1-9 pubmed publisher
    ..g., nanomolar for heme coordination in the allosteric site of guanylate cyclase (sGC) enzyme]; 2) the type of chemical bound to the nitrosated group (i.e...
  25. Tan C, Loh Y, Ch ng Y, Ng C, Yeap Z, Ahmad M, et al. Vasorelaxant and chemical fingerprint studies of Citrus reticulatae pericarpium extracts. J Ethnopharmacol. 2019;232:135-144 pubmed publisher
    ..blocker), atropine (muscarinic receptor blocker), Nω-nitro-L-arginine methyl ester (NO synthase inhibitor), ODQ (sGC inhibitor), indomethacin (COX inhibitor), 4-aminopyridine (KV blocker), barium chloride (Kir ..
  26. Koul V, Kaur A, Singh A. Investigation of the role of nitric oxide/soluble guanylyl cyclase pathway in ascorbic acid-mediated protection against acute kidney injury in rats. Mol Cell Biochem. 2015;406:1-7 pubmed publisher
    The present study investigated the possible involvement of nitric oxide/soluble guanylyl cyclase (NO/sGC) pathway in ascorbic acid (AA)-mediated protection against acute kidney injury (AKI) in rats...
  27. Huo L, Zhang J, Qu Z, Chen H, Li Y, Gao W. Vasorelaxant effects of Shunaoxin pill are mediated by NO/cGMP pathway, HO/CO pathway and calcium channel blockade in isolated rat thoracic aorta. J Ethnopharmacol. 2015;173:352-60 pubmed publisher
    ..In present study, specific inhibitors including soluble guanylate cyclase (sGC) inhibitor 1 H-[1,2,4]oxadiazolo[4,3-a]quinoxaline-1-one (ODQ), cyclooxygenase (COX) inhibitor indomethacin (INDO), ..
  28. Sun Y, Su X, Jin J, Zhou Z, Sun S, Wen J, et al. Rumex acetosa L. induces vasorelaxation in rat aorta via activation of PI3-kinase/Akt- AND Ca(2+)-eNOS-NO signaling in endothelial cells. J Physiol Pharmacol. 2015;66:907-15 pubmed
    ..The ERA-induced vasorelaxation was abolished by L-NAME (an NOS inhibitor) or ODQ (a sGC inhibitor), but not by indomethacin...
  29. Tiwari S, Ndisang J. Heme oxygenase system and hypertension: a comprehensive insight. Curr Pharm Des. 2014;20:1354-69 pubmed
    ..capable of activating the downstream signaling components of the HO system like the soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP) secondary messenger system...
  30. Zhang W, Ma L, Sui Y, Chang X. [Screening of citrullinated proteins in ten tumor cell lines]. Zhonghua Zhong Liu Za Zhi. 2015;37:165-9 pubmed
    ..cancer cells), Lovo (colon cancer cells), OS-RC (renal cell carcinoma cells), PANC-1 (pancreatic cancer cells), and SGC (gastric cancer cells)...
  31. Fouda M, El Gowelli H, El Gowilly S, El Mas M. The estrogen-dependent baroreflex dysfunction caused by nicotine in female rats is mediated via NOS/HO inhibition: Role of sGC/PI3K/MAPKERK. Toxicol Appl Pharmacol. 2015;289:466-73 pubmed publisher
    ..modulated by nitric oxide synthase (NOS) and/or heme oxygenase (HO) and their downstream soluble guanylate cyclase (sGC)/phosphatidylinositol 3-kinase (PI3K)/mitogen-activated protein kinases (MAPKs) signaling...
  32. Nakamura T, Zhu G, Ranek M, Kokkonen Simon K, Zhang M, Kim G, et al. Prevention of PKG-1α Oxidation Suppresses Antihypertrophic/Antifibrotic Effects From PDE5 Inhibition but not sGC Stimulation. Circ Heart Fail. 2018;11:e004740 pubmed publisher
    Stimulation of sGC (soluble guanylate cyclase) or inhibition of PDE5 (phosphodiesterase type 5) activates PKG (protein kinase G)-1α to counteract cardiac hypertrophy and failure...
  33. Bhardwaj M, Sen S, Sharma A, Kashyap S, Chosdol K, Pushker N, et al. ZEB2/SIP1 as novel prognostic indicator in eyelid sebaceous gland carcinoma. Hum Pathol. 2015;46:1437-42 pubmed publisher
    ..planned to explore status of EMT-associated markers ZEB2/SIP1 and E-cadherin in eyelid sebaceous gland carcinoma (SGC) and to correlate with clinicopathological high-risk features...
  34. Wu M, Zhang F, Yu Z, Lin J, Yang L. Chemical characterization and in vitro antitumor activity of a single-component polysaccharide from Taxus chinensis var. mairei. Carbohydr Polym. 2015;133:294-301 pubmed publisher
    ..In vitro anti-tumor experiments with SGC-7901 cells were performed and assessed by MTS (MPEG-2 Transport Stream) method and flow cytometry...
  35. Zhao Y, Vanhoutte P, Leung S. Vascular nitric oxide: Beyond eNOS. J Pharmacol Sci. 2015;129:83-94 pubmed publisher
    ..regulates the degree of contraction of vascular smooth muscle cells mainly by stimulating soluble guanylyl cyclase (sGC) to produce cyclic guanosine monophosphate (cGMP), although cGMP-independent signaling [S-nitrosylation of target ..
  36. Wu C, Cheng J, Hu S, Deng R, Muangu Y, Shi L, et al. Reduced proliferation and increased apoptosis of the SGC‑7901 gastric cancer cell line on exposure to GDC‑0449. Mol Med Rep. 2016;13:1434-40 pubmed publisher
    ..the present study, high-glucose Dulbecco's modified Eagle's medium with 10% fetal bovine serum was used for routine SGC‑7901 cell line culture...
  37. Hansen H, Shi C, Lausche A, Peterson A, Nørskov J. Bifunctional alloys for the electroreduction of CO2 and CO. Phys Chem Chem Phys. 2016;18:9194-201 pubmed publisher
    ..reduction of CO2 and CO to hydrocarbons through a formyl pathway on (111) and (211) facets of L12 alloys with an A3B composition. We find that several alloys may reduce the thermodynamic overpotential for CO reduction by more than 0...
  38. López Barrera D, Vázquez Sánchez K, Loarca Piña M, Campos Vega R. Spent coffee grounds, an innovative source of colonic fermentable compounds, inhibit inflammatory mediators in vitro. Food Chem. 2016;212:282-90 pubmed publisher
    ..The results support the use of SGC in the food industry as dietary fiber source with health benefits.
  39. Wang Y, Hang L, Jiao L, Liu H, Li F. Cytotoxic aspidofractinine alkaloids from Kopsia hainanensis. Fitoterapia. 2017;121:53-57 pubmed publisher
    ..Alkaloids 3 and 4 exhibited some cytotoxic activity against all of six tested tumor cell lines (BGC-823, HepG2, MCF-7, SGC-7901, SK-MEL-2, and SK-OV-3) with IC50 values of 7.3-9.5?M and 9.2-10.6?M, respectively.
  40. Liu Y, Wang C, Jiang Z. [The expression of retrogene Nanogp8 is related to the biological characteristics of human SGC-7901 gastric cancer cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015;31:763-8 pubmed
    To explore the effects of NANOGP8 on proliferation, apoptosis, cell cycle, invasion and migration of human SGC-7901 gastric cancer cells...
  41. Tsui L, Chang S, Huang H, Fong T, Wang I. YC-1 induces lipid droplet formation in RAW 264.7 macrophages. J Biomed Sci. 2016;23:2 pubmed publisher
    ..YC-1) is a potential anticancer drug that may activate soluble guanylyl cyclase (sGC) and increase the level of cyclic guanosine monophosphate (cGMP)...
  42. Ji T, Huang X, Jin J, Pan S, Zhuge X. Inhibition of long non-coding RNA TUG1 on gastric cancer cell transference and invasion through regulating and controlling the expression of miR-144/c-Met axis. Asian Pac J Trop Med. 2016;9:508-12 pubmed publisher
    ..The correlation between lncRNA-TUG1 expression and patients' clinical data was classified and analyzed. SGC-7901 cells were transfected using lncRNA-TUG1 specific siRNA...
  43. Gerber L, Jensen F, Madsen S, Marshall W. Nitric oxide inhibition of NaCl secretion in the opercular epithelium of seawater-acclimated killifish, Fundulus heteroclitus. J Exp Biol. 2016;219:3455-3464 pubmed
    ..The effect of SNAP on Isc was abolished by inhibitors of the soluble guanylyl cyclase (sGC), ODQ (10-6 mol l-1) and Methylene Blue (10-4 mol l-1), revealing ..
  44. Zhang J, Shi Z, Huang J, Zou X. CSTB Downregulation Promotes Cell Proliferation and Migration and Suppresses Apoptosis in Gastric Cancer SGC-7901 Cell Line. Oncol Res. 2016;24:487-494 pubmed publisher
    ..Human gastric cancer SGC-7901 cells as a model in vitro were transfected with plasmid PCDNA3.1-CSTB and siRNA-CSTB using Lipofectamine 2000...
  45. Chen F, Qin X, Xu G, Gou S, Jin X. Reversal of cisplatin resistance in human gastric cancer cells by a wogonin-conjugated Pt(IV) prodrug via attenuating Casein Kinase 2-mediated Nuclear Factor-?B pathways. Biochem Pharmacol. 2017;135:50-68 pubmed publisher
    ..Similarly in vivo, in nude mice with SGC-7901/cDDP xenografts, compound 8 improved the effectiveness of DN604 via reversing tumor resistance and maintaining ..
  46. Bradley A, Echalier A, Fairhead M, Strain Damerell C, Brennan P, Bullock A, et al. The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery. Essays Biochem. 2017;61:495-503 pubmed publisher
    ..Therefore the current, fourth funding phase of the Structural Genomics Consortium (SGC), building on its extensive experience in structural biology of novel targets and design of protein inhibitors, ..
  47. Feng L, Wang X, Huang Q. Thymoquinone induces cytotoxicity and reprogramming of EMT in gastric cancer cells by targeting PI3K/Akt/mTOR pathway. J Biosci. 2017;42:547-554 pubmed
    ..current study, we evaluated the anticancer effects of Thymoquinone (TQ) against gastric cancer cells (MGC80-3 and SGC-7901) and normal noncancerous GES-1 cells and attempted to investigate the underlying mechanism...
  48. Fang Q, Chen X, Zhi X. Long Non-Coding RNA (LncRNA) Urothelial Carcinoma Associated 1 (UCA1) Increases Multi-Drug Resistance of Gastric Cancer via Downregulating miR-27b. Med Sci Monit. 2016;22:3506-3513 pubmed
    ..The human gastric cancer cell line SGC-7901, and SGC-7901 derived Adriamycin (doxorubicin) resistant SGC-7901/ADR, cisplatin resistant SGC-7901/DDP, and 5-..
  49. Cai X, Chen L, Song H, Zhang C, Yuan Z, Xiang Z. PLK1 promotes epithelial-mesenchymal transition and metastasis of gastric carcinoma cells. Am J Transl Res. 2016;8:4172-4183 pubmed
    ..com/analysis/). Over-expression of PLK1 in gastric cancer cells SGC-7901 and MKN-28 significantly promoted cells profound morphological changes and enhanced metastatic ability of ..
  50. Li L, Hu M, Zheng L, Zhang C, Li J, Rong R, et al. Endothelin Receptor Down-Regulation Mediated Ligand Regulation Mechanisms Protect Against Cellular Hypoxia Injury in Rat Vascular Endothelial Cells. Cell Physiol Biochem. 2016;40:1443-1454 pubmed publisher
    ..In the L-NAME group, PI3K and p-AKT expression was much higher than the ETaR siRNA group. PKG and sGC expression levels significantly descended after mild oxygen deprivation...
  51. Barragán Iglesias P, Oidor Chan V, Loeza Alcocer E, Pineda Farias J, Velázquez Lagunas I, Salinas Abarca A, et al. Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain. Pharmacol Rep. 2018;70:294-303 pubmed publisher
    The purpose of this study was to evaluate the participation of satellite glial cells (SGC), microglia and astrocytes in a model of streptozotocin-induced diabetes initiated in neonatal rats (nSTZ) and to determine the pharmacological ..
  52. Tan C, Yam M. Mechanism of vasorelaxation induced by 3'-hydroxy-5,6,7,4'-tetramethoxyflavone in the rats aortic ring assay. Naunyn Schmiedebergs Arch Pharmacol. 2018;391:561-569 pubmed publisher
    ..The present study demonstrates the vasorelaxant effect of TMF involves NO/sGC/cGMP and prostacyclin pathways, calcium and potassium channels and muscarinic and beta-adrenergic receptors.
  53. Mendes Silverio C, Lescano C, Zaminelli T, Sollon C, Anhê G, Antunes E, et al. Activation of soluble guanylyl cyclase with inhibition of multidrug resistance protein inhibitor-4 (MRP4) as a new antiplatelet therapy. Biochem Pharmacol. 2018;152:165-173 pubmed publisher
    ..GMP are controlled by its rate of formation through nitric oxide-mediated stimulation of soluble guanylate cyclase (sGC) and its degradation by phosphodiesterases...
  54. Ni L, Zhong X, Cai J, Bao M, Zhang B, Wu J, et al. Five New Alkaloids from Cephalotaxus lanceolata and C. fortunei var. alpina. Nat Prod Bioprospect. 2016;6:149-54 pubmed publisher
    ..The new structures were elucidated based on spectroscopic data including 1D and 2D NMR, FTIR, UV and MS. These new alkaloids showed no cytotoxicity to HeLa, SGC-7901 gastric cancer, and A-549 lung cancer cell lines.
  55. Dordea A, Vandenwijngaert S, Garcia V, Tainsh R, Nathan D, Allen K, et al. Androgen-sensitive hypertension associated with soluble guanylate cyclase-?1 deficiency is mediated by 20-HETE. Am J Physiol Heart Circ Physiol. 2016;310:H1790-800 pubmed publisher
    ..We previously reported that mice deficient in the ?1-subunit of the NO receptor soluble guanylate cyclase (sGC?1 (-/-) mice) display sex- and strain-specific hypertension: male but not female sGC?1 (-/-) mice are hypertensive ..
  56. Lin H, Yang G, Ding B, Zhang M, Zhang M, Yan F, et al. Secreted frizzled-related protein 1 overexpression in gastric cancer: Relationship with radiological findings of dual-energy spectral CT and PET-CT. Sci Rep. 2017;7:42020 pubmed publisher
    ..We established mouse metastatic models using the SGC-7901/sFRP1 gastric cancer cell line. A control group was established using the SGC-7901/vector cell line...
  57. Gong H, Li S, He L, Kasimu R. Microscopic identification and in vitro activity of Agastache rugosa (Fisch. et Mey) from Xinjiang, China. BMC Complement Altern Med. 2017;17:95 pubmed publisher
    ..GC-MS analysis, the MTT assay showed a dose and time-dependent increase in damage for gastric cancer cell line SGC-7901...
  58. Penna C, Tullio F, Femminò S, Rocca C, Angelone T, Cerra M, et al. Obestatin regulates cardiovascular function and promotes cardioprotection through the nitric oxide pathway. J Cell Mol Med. 2017;21:3670-3678 pubmed publisher
    ..conditions and induces cardioprotection by mechanisms dependent on activation of an NO/soluble guanylate cyclase (sGC)/PKG pathway...
  59. Benke K, Mátyás C, Sayour A, Olah A, Németh B, Ruppert M, et al. Pharmacological preconditioning with gemfibrozil preserves cardiac function after heart transplantation. Sci Rep. 2017;7:14232 pubmed publisher
    ..Pharmacological activation of soluble guanylate cyclase (sGC) and increased cGMP-signalling have been reported to have cardioprotective properties...
  60. Barrier M, Bégorre M, Baudrimont I, Dubois M, Freund Michel V, Marthan R, et al. Involvement of Heme Oxygenase-1 in particulate matter-induced impairment of NO-dependent relaxation in rat intralobar pulmonary arteries. Toxicol In Vitro. 2016;32:205-11 pubmed publisher
    ..HO-1 and soluble guanylyl-cyclase (sGC) mRNA and protein expressions were assessed by qRT-PCR and Western blotting, respectively...
  61. Dai J, Qian C, Su M, Chen M, Chen J. Gastrokine-2 suppresses epithelial mesenchymal transition through PI3K/AKT/GSK3? signaling in gastric cancer. Tumour Biol. 2016;37:12403-12410 pubmed
    ..Our previous study showed that Gastrokine-2 (GKN2) can inhibit the metastasis of SGC-7901 and AGS cells...
  62. Li C, Zou J, Zheng G, Chu J. MiR-30a Decreases Multidrug Resistance (MDR) of Gastric Cancer Cells. Med Sci Monit. 2016;: pubmed
    ..Chemosensitivity was assessed after completion of the chemotherapy. SGC-7901 and SGC-7901/DDP cells were transfected for miR-30a overexpression or knockdown...
  63. Ren K, Li Z, Li Y, Zhang W, Han X. Long Noncoding RNA Taurine-Upregulated Gene 1 Promotes Cell Proliferation and Invasion in Gastric Cancer via Negatively Modulating miRNA-145-5p. Oncol Res. 2017;25:789-798 pubmed publisher
    ..BGC-823 and SGC-7901 cells were transfected with si-TUG1, pcDNA 3.1-TUG1, miR-145-5p mimics, or matched controls...
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    ..whole blood showed an increase in P-VASPSer239, which was inhibited by ODQ, a soluble guanylyl cyclase (sGC) inhibitor. Immediately and 60 min after nitrite inhalation, P-VASPSer239 increased in platelets...
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    The APOBEC3B (A3B) single-stranded DNA (ssDNA) cytosine deaminase has important roles in innate immunity but is also a major endogenous source of mutations in cancer...
  66. Monti M, Hyseni I, Pacini A, Monzani E, Casella L, Morbidelli L. Cross-talk between endogenous H2S and NO accounts for vascular protective activity of the metal-nonoate Zn(PipNONO)Cl. Biochem Pharmacol. 2018;152:143-152 pubmed publisher
    ..The mechanisms responsible for H2S increase seemed to depend on the NONO moiety/sGC/cGMP pathway and zinc-associated ROS production...
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    ..Thirteen patients showed alpha-sarcoglycan deficient LGMD2D, 7 patients beta-sarcoglycan deficient LGMD2E, 3 patients gamma-sarcoglycan deficient LGDM2C, and one patient delta-sarcoglycan deficient LGMD2F...
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    ..To examine if signaling of nitric oxide-induced soluble guanylyl cyclase (sGC)/cGMP/protein kinase G can cause Na(+)-K(+) pump stimulation by counteracting PKC/NADPH oxidase-dependent ..
  69. Meng Y, Zhao Y, Kuai Z, Liu L, Li W. Synthesis and antitumor activity evaluation of novel oleanolic acid derivatives. J Asian Nat Prod Res. 2017;19:1000-1010 pubmed publisher
    ..The lab results revealed that all these compounds displayed some antitumor activity against SGC-7901 and A-549 cell lines...
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    ..and adjacent non-cancer tissues (ANCTs) by immunohistochemistry, in three human GC cell lines (MGC-803, BGC-823 and SGC-7901) by reverse transcription-PCR and western blot. CXCR7 was stably knocked down via lentiviral vectors...
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    ..Both in vitro and in vivo assays indicated that DN604 could effectively inhibit cell viability of SGC-7901 gastric cancer cells and exhibited stronger antitumor activity than carboplatin and comparable activity to ..
  72. Zhao Y, Liu Y, Zhao Y, Li Q, Zhang M, Chen Y. Activation of satellite glial cells in the trigeminal ganglion contributes to masseter mechanical allodynia induced by restraint stress in rats. Neurosci Lett. 2015;602:150-5 pubmed publisher
    ..in neurons was significantly increased after chronic restraint stress, whereas injection of L-α-aminoadipate (a SGC inhibitor, LAA) into the TG dramatically inhibited the overexpression of these proteins...
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    ..b>SGC-7901 cell lines of high CIAPIN1 expression and low CIAPIN1 expression were established...
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    ..or 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ, 1 μmol/L), an inhibitor of soluble guanylyl cyclase (sGC), and in eNOS(+/+) and eNOS(+/-) mice fed a control (10%) or a 45% HFD (kcal from fat)...
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    ..Furthermore, the CXCR7 gene was silenced and overexpressed in human gastric cancer SGC-7901 cells, and cell proliferation, migration and invasiveness were measured by the MTT, wound healing and ..
  76. Tao Y, Song Y, Han T, Wang C, Zhao T, Gu Y. miR-205 regulation of ICT1 has an oncogenic potential via promoting the migration and invasion of gastric cancer cells. Biomed Pharmacother. 2017;96:191-197 pubmed publisher
    ..ICT1 overexpression promoted the mobility of SGC-7901 cells...
  77. Yang Y, Li X, Du J, Yin Y, Li Y. Involvement of microRNAs-MMPs-E-cadherin in the migration and invasion of gastric cancer cells infected with Helicobacter pylori. Exp Cell Res. 2018;367:196-204 pubmed publisher
    ..pylori. The results showed that H. pylori induced migration and invasion of SGC-7901 cells with a down-regulation of E-cadherin expression, which were abolished by MMPs knock down, E-cadherin ..
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    ..We report that APOBEC3B (A3B) is required for regulation of gene expression by ER and acts by causing C-to-U deamination at ER binding regions...
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    In this article, the in vitro cytotoxicity of platycodin D was evaluated in human PC-12, SGC-7901, BEL-7402, HeLa and A549 cancer cell lines. PC-12 cells were sensitive to platycodin D treatment, with an IC50 value of 13.5±1.2?M...
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    Soluble guanylate cyclase (sGC) is a receptor for nitric oxide (NO). Binding of NO to ferrous (Fe(2+)) heme increases its catalytic activity, leading to the production of cGMP from GTP...
  81. Iwaki F, Amano H, Ohura K. Nicorandil inhibits osteoclast differentiation in vitro. Eur J Pharmacol. 2016;793:14-20 pubmed publisher
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  82. Dove S. Mammalian Nucleotidyl Cyclases and Their Nucleotide Binding Sites. Handb Exp Pharmacol. 2017;238:49-66 pubmed publisher
    Mammalian membranous and soluble adenylyl cyclases (mAC, sAC) and soluble guanylyl cyclases (sGC) generate cAMP and cGMP from ATP and GTP, respectively, as substrates...
  83. Ding Y, Yao P, Hong T, Han Z, Zhao B, Chen W. The NO-cGMP-PKG signal transduction pathway is involved in the analgesic effect of early hyperbaric oxygen treatment of neuropathic pain. J Headache Pain. 2017;18:51 pubmed publisher
    ..for 5 days; menstruum NS, DMSO, NO synthase(NOS) nonspecific inhibitor (L-NAME), soluble guanylyl cyclase(sGC) inhibitor (ODQ) and protein kinase G(PKG) inhibitor (KT5823) were administered intrathecally 30 minutes prior to ..
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    ..Overexpression of miR‑146a significantly increased apoptosis of SGC‑7901 cells, whereas inhibition of miR‑146a protected cells from apoptosis...
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    ..Human APOBEC3B (A3B) shows strong virus restriction activities in a variety of experimental systems, and is subjected to tight post-..
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    ..beta-sarcoglycan (SGCB) was initially transcribed in a ubiquitous manner, and, toward the second part of the embryonic period, became ..
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    ..These findings are important as they contribute to a greater understanding of the structural determinants required for proper sarcoglycan-sarcospan expression and function. ..
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    Hypoxia upregulates endothelial (e) nitric oxide synthase (NOS), but how eNOS affects soluble guanylate cyclase (sGC) protein expression in hypoxia-induced pulmonary hypertension is unknown...
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    ..The deleted region contains the beta-sarcoglycan gene (SGCB), the predicted gene SPATA18 (spermatogenesis associated 18 homolog) and several expressed sequence tags...
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    ..no established algorithm for the molecular profiling of therapy-relevant defects in salivary gland carcinomas (SGC). HER2 overexpression in a subfraction of SGC and low frequencies of EGFR mutations are known...
  91. Holt A, Martin D, Shaver P, Adderley S, Stone J, Joshi C, et al. Soluble guanylyl cyclase-activated cyclic GMP-dependent protein kinase inhibits arterial smooth muscle cell migration independent of VASP-serine 239 phosphorylation. Cell Signal. 2016;28:1364-79 pubmed publisher
    ..Heme-containing soluble guanylyl cyclase (sGC) synthesizes cyclic guanosine monophosphate (cGMP) and maintains vascular homeostasis predominantly through cGMP-..
  92. Luo X, Peng X, Hou J, Wu S, Shen J, Wang L. Folic acid-functionalized polyethylenimine superparamagnetic iron oxide nanoparticles as theranostic agents for magnetic resonance imaging and PD-L1 siRNA delivery for gastric cancer. Int J Nanomedicine. 2017;12:5331-5343 pubmed publisher
    ..transfection efficiency and cellular internalization in the folate receptor-overexpressing gastric cancer cell line SGC-7901 than a non-FA-conjugated polyplex...