SFTPB

Summary

Gene Symbol: SFTPB
Description: surfactant protein B
Alias: PSP-B, SFTB3, SFTP3, SMDP1, SP-B, 18 kDa pulmonary-surfactant protein, 6 kDa protein, pulmonary surfactant-associated protein B, pulmonary surfactant-associated proteolipid SPL(Phe)
Species: human

Top Publications

  1. ncbi Ceramide decreases surfactant protein B gene expression via downregulation of TTF-1 DNA binding activity
    Loretta Sparkman
    Dept of Molecular Biology, University of Texas Health Center at Tyler, TX 75708 3154, USA
    Am J Physiol Lung Cell Mol Physiol 290:L351-8. 2006
  2. pmc Polymorphic variation in surfactant protein B is associated with COPD exacerbations
    M G Foreman
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Eur Respir J 32:938-44. 2008
  3. ncbi Dysfunction of pulmonary surfactant in chronically ventilated premature infants
    Jeffrey D Merrill
    Neonatology, Department of Pediatrics, University of Pennsylvania School of Medicine, USA
    Pediatr Res 56:918-26. 2004
  4. ncbi Structure and organization of the gene encoding human pulmonary surfactant proteolipid SP-B
    T J Pilot-Matias
    Corporate Molecular Biology, Abbott Laboratories, IL 60064
    DNA 8:75-86. 1989
  5. ncbi Nitric oxide inhibits surfactant protein B gene expression in lung epithelial cells
    Darrell Salinas
    Department of Molecular Biology, University of Texas Health Center at Tyler, Tyler, Texas 75708 3154, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1153-65. 2003
  6. ncbi Surfactant protein B in type II pneumocytes and intra-alveolar surfactant forms of human lungs
    Frank Brasch
    Department of Anatomy, University of Gottingen, Gottingen, Germany
    Am J Respir Cell Mol Biol 30:449-58. 2004
  7. pmc Differences in N-linked glycosylation between human surfactant protein-B variants of the C or T allele at the single-nucleotide polymorphism at position 1580: implications for disease
    Guirong Wang
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Biochem J 369:179-84. 2003
  8. pmc Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations
    Craig P Hersh
    Channing Laboratory, Pulmonary and Critical Care Division, and Hematology Oncology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 33:71-8. 2005
  9. ncbi Genetic variant characterization in intron 4 of the surfactant protein B gene
    Aaron Hamvas
    Division of Newborn Medicine, Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri, USA
    Hum Mutat 26:494-5. 2005
  10. ncbi Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung
    Frank Brasch
    Department of Anatomy, University of Gottingen, Kreuzbergring 36, D 37075 Gottingen, Germany
    J Biol Chem 278:49006-14. 2003

Research Grants

  1. SURFACTANT PROTEINS AND RESPIRATORY DISTRESS SYNDROME
    Joanna Floros; Fiscal Year: 2007
  2. Growth Factor Protection in Acute Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2009
  3. EPIDEMIOLOGY OF SURFACTANT PROTEIN-B DEFICIENCY
    FRANCIS COLE; Fiscal Year: 2009
  4. SURFACTANT PROTEINS AND RESPIRATORY DISTRESS SYNDROME
    Joanna Floros; Fiscal Year: 2009
  5. Genetic Regulation of Surfactant Deficiency
    FRANCIS COLE; Fiscal Year: 2009
  6. EPIDEMIOLOGY OF SURFACTANT PROTEIN-B DEFICIENCY
    FRANCIS SESSIONS COLE; Fiscal Year: 2010
  7. EPIDEMIOLOGY OF SURFACTANT PROTEIN-B DEFICIENCY
    F Cole; Fiscal Year: 2007
  8. Genetic Regulation of Surfactant Deficiency
    FRANCIS SESSIONS COLE; Fiscal Year: 2010
  9. Growth Factor Protection in Acute Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2007
  10. In Vivo Metabolism of Pulmonary Surfactant in Infants
    Aaron Hamvas; Fiscal Year: 2005

Scientific Experts

Detail Information

Publications115 found, 100 shown here

  1. ncbi Ceramide decreases surfactant protein B gene expression via downregulation of TTF-1 DNA binding activity
    Loretta Sparkman
    Dept of Molecular Biology, University of Texas Health Center at Tyler, TX 75708 3154, USA
    Am J Physiol Lung Cell Mol Physiol 290:L351-8. 2006
    ..Chemical inhibitors of de novo ceramide synthesis and sphingomyelin hydrolysis had no effect on TNF-alpha inhibition of SP-B promoter activity and mRNA levels, suggesting that ceramide does not play a role in the inhibition...
  2. pmc Polymorphic variation in surfactant protein B is associated with COPD exacerbations
    M G Foreman
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Eur Respir J 32:938-44. 2008
    ..activator inhibitor type 1), member 2 (SERPINE2), glutathione S-transferase pi (GSTP1) and surfactant protein B (SFTPB) were genotyped in 389 non-Hispanic white participants in the National Emphysema Treatment Trial...
  3. ncbi Dysfunction of pulmonary surfactant in chronically ventilated premature infants
    Jeffrey D Merrill
    Neonatology, Department of Pediatrics, University of Pennsylvania School of Medicine, USA
    Pediatr Res 56:918-26. 2004
    ..We conclude that most premature infants requiring continued respiratory support after 7 d of age experience transient episodes of dysfunctional surfactant that are associated with a deficiency of SP-B and SP-C...
  4. ncbi Structure and organization of the gene encoding human pulmonary surfactant proteolipid SP-B
    T J Pilot-Matias
    Corporate Molecular Biology, Abbott Laboratories, IL 60064
    DNA 8:75-86. 1989
    ..Southern blotting of human genomic DNA probed with SP-B cDNA indicated the presence of only one SP-B gene in the human genome, and the gene was localized to chromosome 2...
  5. ncbi Nitric oxide inhibits surfactant protein B gene expression in lung epithelial cells
    Darrell Salinas
    Department of Molecular Biology, University of Texas Health Center at Tyler, Tyler, Texas 75708 3154, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1153-65. 2003
    ..These data imply that reduced SP-B expression due to elevated NO levels can contribute to lung injury...
  6. ncbi Surfactant protein B in type II pneumocytes and intra-alveolar surfactant forms of human lungs
    Frank Brasch
    Department of Anatomy, University of Gottingen, Gottingen, Germany
    Am J Respir Cell Mol Biol 30:449-58. 2004
    ..In human lungs, mature SP-B is involved in the structural organization of lamellar bodies and tubular myelin by the formation of core particles...
  7. pmc Differences in N-linked glycosylation between human surfactant protein-B variants of the C or T allele at the single-nucleotide polymorphism at position 1580: implications for disease
    Guirong Wang
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Biochem J 369:179-84. 2003
    ..Further, we speculate that, given the fact that this SNP is found frequently in the general population, N-linked glycosylation at residue Asn129 interferes with SP-B processing, secretion and folding under certain disease conditions...
  8. pmc Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations
    Craig P Hersh
    Channing Laboratory, Pulmonary and Critical Care Division, and Hematology Oncology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 33:71-8. 2005
    ..02), a coding variant in surfactant protein B (SFTPB Thr131Ile) (P = 0.03), and the (GT)(31) allele of the heme oxygenase (HMOX1) promoter short tandem repeat (P = 0...
  9. ncbi Genetic variant characterization in intron 4 of the surfactant protein B gene
    Aaron Hamvas
    Division of Newborn Medicine, Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri, USA
    Hum Mutat 26:494-5. 2005
    Genetic variants in intron 4 of the surfactant protein B gene SFTPB have been associated with pulmonary morbidity in newborn infants and adults...
  10. ncbi Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung
    Frank Brasch
    Department of Anatomy, University of Gottingen, Kreuzbergring 36, D 37075 Gottingen, Germany
    J Biol Chem 278:49006-14. 2003
    ..Two of the four processing products generated in vitro were also detected in type-II pneumocytes. In conclusion, our results show that napsin A is involved in the N- and C-terminal processing of proSP-B in type-II pneumocytes...
  11. ncbi Surfactant-associated protein B kinetics in vivo in newborn infants by stable isotopes
    Paola Cogo
    Department of Pediatrics, University of Padova, Padova, and Pharmacy, Salesi Children Hospital, Ancona, Italy
    Pediatr Res 57:519-22. 2005
    ..SP-B half-life seemed to be shorter than DSPC half-life. These results agree with existing animal data. We conclude that the measurement of SP-B kinetics is feasible in vivo in humans by stable isotope technology...
  12. ncbi Intracellular localization of processing events in human surfactant protein B biosynthesis
    A Korimilli
    Division of Neonatology, University of Pennsylvania School of Medicine, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 275:8672-9. 2000
    ....
  13. pmc A mutation in the surfactant protein B gene responsible for fatal neonatal respiratory disease in multiple kindreds
    L M Nogee
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287
    J Clin Invest 93:1860-3. 1994
    ..We conclude that this mutation is responsible for SP-B deficiency and neonatal alveolar proteinosis in multiple families and speculate that the disorder is more common than was recognized previously...
  14. pmc Comprehensive genetic variant discovery in the surfactant protein B gene
    Aaron Hamvas
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Pediatr Res 62:170-5. 2007
    Completely penetrant mutations in the surfactant protein B gene (SFTPB) and >75% reduction of SFTPB expression disrupt pulmonary surfactant function and cause neonatal respiratory distress syndrome...
  15. pmc Genetic association analysis of functional impairment in chronic obstructive pulmonary disease
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 173:977-84. 2006
    ..This variation may reflect different COPD subtypes, which may have different genetic predispositions...
  16. ncbi PARP-2 interacts with TTF-1 and regulates expression of surfactant protein-B
    Yutaka Maeda
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 281:9600-6. 2006
    ..Both PARP-1 and PARP-2 enhanced the activity of the promoter of surfactant protein-B (Sftpb gene) but not other surfactant proteins in vitro...
  17. ncbi The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SP-B) and -C (SP-C) promoters in lung cells
    Meng Chun Yang
    Department of Internal Medicine, Pulmonary and Critical Care Medicine, UT Southwestern Medical Center, Dallas, TX 75390 9034, USA
    Biochem Biophys Res Commun 344:484-90. 2006
    ..Thus, a dimerized complex structure was needed for advanced promoter activity. This result also provided a molecular mechanism by which both the SP-B and SP-C promoters could be differentially regulated by the same complex...
  18. pmc Expression profiles of hydrophobic surfactant proteins in children with diffuse chronic lung disease
    Matthias Griese
    Kinderklinik and Poliklinik, Dr von Haunersches Kinderspital, Ludwig Maximilians University, Munich, Germany
    Respir Res 6:80. 2005
    ..The profile of these proteins in the alveolar space is unknown in such subjects...
  19. ncbi Mapping the human pulmonary surfactant-associated protein B gene (SFTP3) to chromosome 2p12-->p11.2
    N C Vamvakopoulos
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda MD
    Cytogenet Cell Genet 68:8-10. 1995
    ..We have mapped the human SP-B gene (SFTP3) to chromosome 2, band 2p12-->p11.2 by fluorescent in situ hybridization.
  20. ncbi Processing of pulmonary surfactant protein B by napsin and cathepsin H
    Takayuki Ueno
    Cancer Center Karolinska, Department of Oncology Pathology, Karolinska Institute and Hospital, SE 171 76 Stockholm, Sweden
    J Biol Chem 279:16178-84. 2004
    ..These results suggest that napsin, cathepsin H, and at least one other enzyme are involved in maturation of the biologically active SP-B peptide...
  21. pmc Use of human surfactant low molecular weight apoproteins in the reconstitution of surfactant biologic activity
    S D Revak
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037
    J Clin Invest 81:826-33. 1988
    ..5% SP 9 yielded a moderate increase. These data show the ability to produce biologically active surfactant by the addition of isolated LMW apoproteins to defined PL...
  22. ncbi Isolation of a cDNA clone encoding a high molecular weight precursor to a 6-kDa pulmonary surfactant-associated protein
    K A Jacobs
    J Biol Chem 262:9808-11. 1987
    ..Immunoprecipitation of the 42-kDa primary translation product is inhibited by the presence of the bovine 6-kDa protein. These observations suggest a precursor-product relationship of the 42-kDa protein to one of the 6-kDa proteins...
  23. ncbi N-terminally extended surfactant protein (SP) C isolated from SP-B-deficient children has reduced surface activity and inhibited lipopolysaccharide binding
    Jing Li
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Biochemistry 43:3891-8. 2004
    ..The results of this study indicate that the early postnatal fatal respiratory distress seen in SP-B-deficient children is combined with the near absence of active variants of SP-C...
  24. ncbi Compound SFTPB 1549C-->GAA (121ins2) and 457delC heterozygosity in severe congenital lung disease and surfactant protein B (SP-B) deficiency
    M Tredano
    Service de Biochimie et Biologie Moléculaire, Hopital d Enfants Armand Trousseau, Paris, France
    Hum Mutat 14:502-9. 1999
    ..Homozygosity for a common mutation (1549C-->GAA, or 121ins2) of the SP-B-encoding gene (SFTPB) results in rapidly fatal respiratory failure, with complete absence of the mRNA and protein observed in lung ..
  25. pmc Pulmonary surfactant surface tension influences alveolar capillary shape and oxygenation
    Machiko Ikegami
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Respir Cell Mol Biol 41:433-9. 2009
    ..our hypothesis, surfactant surface tension was regulated by conditional expression of surfactant protein (SP)-B in Sftpb(-/-) mice, thereby inhibiting surface tension-lowering properties of surfactant in vivo within 24 hours after ..
  26. pmc Inherited surfactant deficiency caused by uniparental disomy of rare mutations in the surfactant protein-B and ATP binding cassette, subfamily a, member 3 genes
    Aaron Hamvas
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Pediatr 155:854-859.e1. 2009
    To characterize inheritance of homozygous, rare, recessive loss-of-function mutations in surfactant protein-B (SFTPB) or ATP binding cassette, subfamily A, member 3 (ABCA3) genes in newborns with lethal respiratory failure.
  27. ncbi Role of endogenous TGF-beta in glucocorticoid-induced lung type II cell differentiation
    Theresa M McDevitt
    Division of Neonatology, Department of Pediatrics, University of California San Francisco, 3333 California St, Suite 150, San Francisco, CA 94118 1981, USA
    Am J Physiol Lung Cell Mol Physiol 292:L249-57. 2007
    ..blockade of TGF-beta reduced serpine1, a TGF-beta-inducible gene, and increased gene expression for sftpa, sftpb, sftpc, and titf1, mimicking the response to hormone treatment...
  28. ncbi Relation between perceived stimulus intensity and exteroceptive reflex responses in the human masseter muscles
    P O Hansen
    Danish Pain Research Centre and Department of Neurology, Aarhus University Hospital
    Clin Neurophysiol 110:1290-6. 1999
    ..In the present study, the relationship between nociception and ES1, ISP and PSP was investigated...
  29. pmc C/EBP{alpha} is required for pulmonary cytoprotection during hyperoxia
    Yan Xu
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 297:L286-98. 2009
    ..of number of genes regulating surfactant lipid and protein homeostasis, including Srebf, Scap, Lpcat1, Abca3, Sftpb, and Napsa...
  30. pmc Epigenetic mechanisms modulate thyroid transcription factor 1-mediated transcription of the surfactant protein B gene
    YuXia Cao
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 285:2152-64. 2010
    ..Surfactant protein B (Sftpb) is a developmentally regulated lung epithelial gene critical for lung function...
  31. pmc Recombination as a mechanism for sporadic mutation in the surfactant protein-C gene
    Amy D McBee
    Division of Newborn Medicine, Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    Pediatr Pulmonol 43:443-50. 2008
    To determine haplotype background of common mutations in the genes encoding surfactant proteins B and C (SFTPB and SFTPC) and to assess recombination in SFTPC.
  32. ncbi Novel mutations in the gene encoding ATP binding cassette protein member A3 (ABCA3) resulting in fatal neonatal lung disease
    Ola D Saugstad
    Department of Pediatric Research, Rikshospitalet Radiumhospitalet Health Trust, University of Oslo, Oslo, Norway
    Acta Paediatr 96:185-90. 2007
    ..To investigate whether intractable respiratory distress syndrome in three Norwegian term infants was due to mutations in the ABCA3 gene...
  33. doi Novel strategy to identify genetic risk factors for COPD severity: a genetic isolate
    C C van Diemen
    Dept of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur Respir J 35:768-75. 2010
    ..MMP9, MMP12, tissue inhibitor of metalloprotease-1 gene (TIMP1), surfactant protein A1 gene (SFTPA1 ), SFTPA2, SFTPB, SFTPD, glutathione S-transferase P1 gene (GSTP1), and haem oxygenase 1 gene ( HMOX1)...
  34. ncbi Immunohistochemical markers in diagnosis of papillary thyroid carcinoma: Utility of HBME1 combined with CK19 immunostaining
    Michel R Nasr
    Department of Pathology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    Mod Pathol 19:1631-7. 2006
    ..cases of papillary thyroid carcinoma were initially stained for HBME1, CK19, fibronectin1, Ki-67, Calretinin, p16, SFTPB and CITED1...
  35. doi Porcine lung surfactant protein B gene (SFTPB): cDNA sequencing, chromosomal location, and expression studies
    S Cirera
    Department of Animal and Veterinary Basic Sciences, Division of Genetics and Bioinformatics, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    Anim Biotechnol 19:127-37. 2008
    The porcine surfactant protein B (SFTPB) is a single copy gene on chromosome 3. Three different cDNAs for the SFTPB have been isolated and sequenced...
  36. ncbi A murine respiratory-inducing niche displays variable efficiency across human and mouse embryonic stem cell species
    Mark Denham
    Centre for Reproduction and Development, Monash Institute of Medical Research, Monash University, Clayton, Australia, Australia
    Am J Physiol Lung Cell Mol Physiol 292:L1241-7. 2007
    ..Expression of other terminal lung secretory unit markers (TITF1, SFTPA, and SFTPB) was not detected at any time point analyzed...
  37. pmc Misexpression of MIA disrupts lung morphogenesis and causes neonatal death
    Sui Lin
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Dev Biol 316:441-55. 2008
    ..with exogenous MIA caused significant reductions in the expression of the lung differentiation markers Sftpa, Sftpb, Sftpc, and Abca3. Bitransgenic mice expressing MIA under the control of the SFTPC promoter after E16...
  38. pmc Calcineurin/Nfat signaling is required for perinatal lung maturation and function
    Vrushank Dave
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Clin Invest 116:2597-609. 2006
    ..3 (Nfatc3), a transcription factor modulated by calcineurin, was identified as a direct activator of Sftpa, Sftpb, Sftpc, Abca3, Foxa1, and Foxa2 genes...
  39. ncbi Evaluation and management of inherited disorders of surfactant metabolism
    Aaron Hamvas
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Chin Med J (Engl) 123:2943-7. 2010
    ..outcomes of children with inherited disorders of surfactant metabolism due to mutations in the genes encoding surfactant proteins-B or -C (SFTPB, SFTPC), ATP binding cassette member A3 (ABCA3), and thyroid transcription factor (NKX2.1).
  40. pmc A combination of molecular markers accurately detects lymph node metastasis in non-small cell lung cancer patients
    Liqiang Xi
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 12:2484-91. 2006
    ..A combination of three markers (SFTPB, TACSTD1, and PVA) was identified that provided perfect classification of benign and positive nodes in all sample ..
  41. pmc ErbB4 is an upstream regulator of TTF-1 fetal mouse lung type II cell development in vitro
    Katja Zscheppang
    Department of Pediatrics, Hannover Medical School, Hannover 30625, Germany Division of Newborn Medicine, Floating Hospital for Children at Tufts Medical Center, Boston, MA 02111, USA
    Biochim Biophys Acta 1833:2690-702. 2013
    ..We speculate that ErbB4 is an upstream regulator of TTF-1 and regulates Sftpb expression via this pathway in alveolar type II cells...
  42. ncbi Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors
    Changgong Li
    Department of Pediatrics, Women s and Children s Hospital, University of Southern California School of Medicine, Los Angeles, California 90033, USA
    J Biol Chem 277:38399-408. 2002
    ..1 was not affected. We conclude that SMAD3 interactions with the positive regulators NKX2.1 and HNF-3 underlie the molecular basis for TGF-beta-induced repression of Sp-B gene transcription...
  43. ncbi Dimeric surfactant protein B peptide sp-b(1-25) in neonatal and acute respiratory distress syndrome
    Frans J Walther
    Research and Education Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Exp Lung Res 28:623-40. 2002
    ..The data suggest that dSP-B(1-25) is more efficient in restoring lung function in neonatal RDS and ARDS than mSP-B(1-25) surfactant...
  44. ncbi Surfactant protein B gene polymorphism in preterm babies with respiratory distress syndrome
    P P R Lyra
    Departamento de Pediatria, Universidade de Sao Paulo, SP, Brasil
    Braz J Med Biol Res 44:66-72. 2011
    ..1681; 95%CI = 0.0426-0.6629). We did not detect differences in the frequencies of the other polymorphisms between the two groups of newborns...
  45. doi Identification of seven novel SMPD1 mutations causing Niemann-Pick disease types A and B
    P Irun
    Departamento de Bioquimica y Biologia Molecular y Celular, Universidad de Zaragoza, Zaragoza, Spain Instituto de Investigación Sanitaria de Aragón IIS, Zaragoza, Spain Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER, Zaragoza U752, Barcelona U719, Spain
    Clin Genet 84:356-61. 2013
    ..Sequencing the SMDP1 gene revealed eight previously described mutations and seven novel mutations including four missense [c...
  46. pmc Surfactant protein B deficiency and gene mutations for neonatal respiratory distress syndrome in China Han ethnic population
    Xiaojuan Yin
    Affiliated Bayi Children s Hospital, Beijing Military Region General Hospital Beijing, China
    Int J Clin Exp Pathol 6:267-72. 2013
    ..To determine whether the SP-B deficiency and gene mutations in exon 4 is associated with neonatal RDS in China Han ethnic population...
  47. doi Differential effects of insulin and dexamethasone on pulmonary surfactant-associated genes and proteins in A549 and H441 cells and lung tissue
    Zdenek Rucka
    Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, 60200 Brno, Czech Republic
    Int J Mol Med 32:211-8. 2013
    ..the expression and mRNA transcription of 4 pulmonary surfactant-associated proteins [surfactant protein (SFTP)A, SFTPB, SFTPC and SFTPD] were examined...
  48. doi Kinetics of plasma SPB and RAGE during mechanical ventilation in patients undergoing major vascular surgery
    Piergiuseppe Agostoni
    Centro Cardiologico Monzino, IRCCS, Milan, Italy
    Respir Physiol Neurobiol 178:256-60. 2011
    ..SPB(N) increase (T(END)-T0), but not RAGE(N), was related to ΔPaO(2)/FiO2 changes during mechanical ventilation (r=0.575, p=0.01). Plasma RAGE(N) and SPB(N) kinetics in patients undergoing major vascular surgery are different...
  49. ncbi Comparison of surfactant protein B polymorphisms of healthy term newborns with preterm newborns having respiratory distress syndrome
    P P R Lyra
    Departamento de Pediatria, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    Braz J Med Biol Res 40:779-86. 2007
    ..These data demonstrate an association of GG genotype with RDS...
  50. pmc Estrogen-induced upregulation of Sftpb requires transcriptional control of neuregulin receptor ErbB4 in mouse lung type II epithelial cells
    Katja Zscheppang
    Department of Pediatrics, Hannover Medical School, 30625 Hannover, Germany
    Biochim Biophys Acta 1813:1717-27. 2011
    ..We hypothesized that estrogen signals its effect on surfactant protein B (Sftpb) expression through interactions of ERβ and ErbB4...
  51. pmc Genetic disorders of surfactant dysfunction
    Susan E Wert
    Perinatal Institute, Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, and the Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Pediatr Dev Pathol 12:253-74. 2009
    ..In general, mutations in the SP-B gene SFTPB are associated with fatal respiratory distress in the neonatal period, and mutations in the SP-C gene SFTPC are ..
  52. pmc Pepsinogen C proteolytic processing of surfactant protein B
    Kristin D Gerson
    Division of Neonatology, Department of Pediatrics, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 283:10330-8. 2008
    ..Inhibition of SP-B production recapitulated the SP-B-deficient phenotype evident by aberrant lamellar body genesis. Together, these data support a primary role for pepsinogen C in SP-B proteolytic processing in alveolar type 2 cells...
  53. pmc Forkhead Box m1 transcription factor is required for perinatal lung function
    Tanya V Kalin
    Division of Pulmonary Biology, Cincinnati Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 105:19330-5. 2008
    ..Foxm1 directly bound and induced transcriptional activity of the mouse surfactant protein B and A (Sftpb and Sftpa) promoters in vitro, indicating that Foxm1 is a direct transcriptional activator of these genes...
  54. pmc Identifying host genetic risk factors in the context of public health surveillance for invasive pneumococcal disease
    Jairam R Lingappa
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e23413. 2011
    ..with IPD in both EA and AA, but with effects in different directions; FAS, IL1B, IL4, IL10, IL12B, SFTPA1, SFTPB, and PTAFR variants are associated (p≤0.05) with IPD in EA or AA...
  55. doi Poly(sulfonated phenylene)-block-Polyimide Copolymers for Fuel Cell Applications
    Huiping Bi
    School of Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei, Nanjing 210094, China Graduate School of Science and Engineering, Yamaguchi University, Tokiwadai 2 16 1, Ube, Yamaguchi 755 8611, Japan
    Macromol Rapid Commun 30:1852-6. 2009
    ..The membranes had a fairly high through-plane conductivity in water and even under low relative humidity. The PSP-b-PI copolymer with an IEC of 1.5 meq · g(-1) showed high PEFC performance due to the high through-plane conductivity...
  56. ncbi Surfactant protein B deficiency caused by a novel mutation involving multiple exons of the SP-B gene
    F A B A Schuerman
    Department of Neonatology, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Med Res 13:281-6. 2008
    Inability to produce surfactant protein (SP)-B causes fatal neonatal respiratory disease. Homozygosity for a frameshift mutation (121ins2) in the gene encoding SP-B (SFTPB) is the predominant but not the exclusive cause of disease.
  57. pmc Foxn4 influences alveologenesis during lung development
    Shengguo Li
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Dev Dyn 240:1512-7. 2011
    ..may result from decreased platelet-derived growth factor-A (PDGFA) signaling and reduced surfactant protein B (SFTPB) expression...
  58. doi Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease
    Jeffrey A Whitsett
    Perinatal Institute, Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Annu Rev Med 61:105-19. 2010
    ..Mutations in the ABCA3, SFTPA, SFTPB, SFTPC, SCL34A2, and TERT genes disrupt type II cell function and/or surfactant homeostasis, causing neonatal ..
  59. doi Surfactant protein-B 121ins2 heterozygosity, reduced pulmonary function, and chronic obstructive pulmonary disease in smokers
    Marie Baekvad-Hansen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark
    Am J Respir Crit Care Med 181:17-20. 2010
    ..Individuals heterozygous for this mutation have partial absence of surfactant protein-B and could be at risk of lung disease when exposed to additional risk factors for impaired surfactant function such as tobacco smoking...
  60. doi NKX2-1 mutations leading to surfactant protein promoter dysregulation cause interstitial lung disease in "Brain-Lung-Thyroid Syndrome"
    Loic Guillot
    INSERM UMR 938, UPMC, Universite Paris 6, France
    Hum Mutat 31:E1146-62. 2010
    NKX2-1 (NK2 homeobox 1) is a critical regulator of transcription for the surfactant protein (SP)-B and -C genes (SFTPB and SFTPC, respectively). We identified and functionally characterized two new de novo NKX2-1 mutations c.493C>T (p...
  61. pmc Association of COPD candidate genes with computed tomography emphysema and airway phenotypes in severe COPD
    W J Kim
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, 02115 USA
    Eur Respir J 37:39-43. 2011
    ..Further investigation will be required to replicate these genetic associations for emphysema and airway wall phenotypes...
  62. doi Accuracy of pregnancy specific protein-B test for early pregnancy diagnosis in dairy cattle
    Juan E Romano
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4475, USA
    Theriogenology 74:932-9. 2010
    ..In conclusion, PSP-B ELISA was a sensitive, specific, and accurate test for pregnancy diagnosis (relative to TRUS) at Days 28, 30, and 35 after breeding...
  63. pmc JUN-CCAAT/enhancer-binding protein complexes inhibit surfactant-associated protein B promoter activity
    Kiflai Bein
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15219 3130, USA
    Am J Respir Cell Mol Biol 45:436-44. 2011
    The murine surfactant-associated protein B (Sftpb) gene promoter, spanning nucleotides -653 to +42, is composed of functionally distinct proximal and distal regions...
  64. pmc Genetic association analysis of COPD candidate genes with bronchodilator responsiveness
    Woo Jin Kim
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Respir Med 103:552-7. 2009
    ..Genotyping was completed for 122 single nucleotide polymorphisms (SNPs) in six candidate genes (EPHX1, SFTPB, TGFB1, SERPINE2, GSTP1, ADRB2)...
  65. pmc Neuregulin receptor ErbB4 functions as a transcriptional cofactor for the expression of surfactant protein B in the fetal lung
    Katja Zscheppang
    Department of Pediatrics, Hannover Medical School, Hannover, Germany
    Am J Respir Cell Mol Biol 45:761-7. 2011
    ..We hypothesized that in the fetal lung, ErbB4 functions as a transcriptional regulator for surfactant protein B (Sftpb), the most critical surfactant protein gene...
  66. pmc Genetic associations with hypoxemia and pulmonary arterial pressure in COPD
    Peter J Castaldi
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Chest 135:737-44. 2009
    ..We sought to identify genetic polymorphisms associated with these traits in a population of patients with severe COPD from the National Emphysema Treatment Trial (NETT)...
  67. pmc Disaturated-phosphatidylcholine and surfactant protein-B turnover in human acute lung injury and in control patients
    Manuela Simonato
    Department of Pediatrics, University of Padova, Padova, Italy
    Respir Res 12:36. 2011
    ..No information is available on their turnover...
  68. ncbi A 10-gene classifier for distinguishing head and neck squamous cell carcinoma and lung squamous cell carcinoma
    Anil Vachani
    University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 13:2905-15. 2007
    ..The distinction between a lung metastasis and a primary LSCC is currently based on certain clinical and histologic criteria, although the accuracy of this approach remains in question...
  69. ncbi Expression and localization of surfactant proteins in human nasal epithelium
    Jin Kook Kim
    Dept of Otorhinolaryngology Head and Neck Sugery, Konkuk University College of Medicine, Seoul
    Am J Physiol Lung Cell Mol Physiol 292:L879-84. 2007
    ..We demonstrate that SP-A, SP-B, and SP-D are expressed in human nasal mucosa and cultured NHNE cells. Further study of the functional role of SPs in the upper airway is required...
  70. ncbi Surfactant protein B polymorphism and respiratory distress syndrome in premature twins
    Riitta Marttila
    Department of Paediatrics and Biocenter Oulu, University of Oulu, Finland
    Hum Genet 112:18-23. 2003
    ..The traditional twin concordance study is insufficient to evaluate genetic predisposition to RDS or other diseases that are confounded by the birth order or multiple pregnancy in itself...
  71. ncbi Surfactant protein B gene variations and susceptibility to lung cancer in chromate workers
    Ashraf A Ewis
    Single Molecule Bioanalysis Laboratory, National Institute of Advanced Industrial Science and Technology AIST, Takamatsu, Japan
    Am J Ind Med 49:367-73. 2006
    ....
  72. ncbi Peroxisome proliferator-activated receptor gamma and ligands inhibit surfactant protein B gene expression in the lung
    Li Yang
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 278:36841-7. 2003
    ..The studies support the concept that surfactant protein B homeostasis is influenced by neutral lipid metabolites in the lung...
  73. ncbi Polymorphism in the surfactant protein-B gene, gender, and the risk of direct pulmonary injury and ARDS
    Michelle Ng Gong
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Goston, MA 02115, USA
    Chest 125:203-11. 2004
    ..To investigate the possibility of variable genetic susceptibility to ARDS, we examined the association between ARDS and a polymorphism in intron 4 of the surfactant protein-B (SP-B) gene...
  74. ncbi [Biologic significance of thyroid transcription factor-1 and surfactant protein expression in pulmonary sclerosing hemangioma]
    Xiang Hua Yi
    Department of Pathology, Shanghai Pulmonary Hospital, Shanghai 200433, China
    Zhonghua Jie He He Hu Xi Za Zhi 26:776-80. 2003
    ..To investigate the biologic significance of thyroid transcription factor-1 (TTF-1) and surfactant protein A (SP-A) and SP-B expression in pulmonary sclerosing hemangioma (PSH)...
  75. ncbi Mutation of SFTPC in infantile pulmonary alveolar proteinosis with or without fibrosing lung disease
    Mohammed Tredano
    Service de Biochimie et Biologie Moléculaire, hôpital d enfants Armand Trousseau AP HP, Paris, France
    Am J Med Genet A 126:18-26. 2004
    ..cases with unexplained respiratory distress (URD) in which surfactant protein B (SP-B) deficiency related to SFTPB mutation had been ruled out. One patient with complete SP-C deficiency had no detectable mutation of SFTPC...
  76. ncbi Data mining and multiparameter analysis of lung surfactant protein genes in bronchopulmonary dysplasia
    Meri Rova
    Department of Paediatrics and Biocenter Oulu, University of Oulu, Oulu, Finland
    Hum Mol Genet 13:1095-104. 2004
    ....
  77. ncbi Mapping and analysis of the lytic and fusogenic domains of surfactant protein B
    Marnie A Ryan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Biochemistry 44:861-72. 2005
    ....
  78. ncbi Surface tension influences cell shape and phagocytosis in alveolar macrophages
    Hiroko Akei
    Cincinnati Children s Hospital, Division of Pulmonary Biology, University of Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 291:L572-9. 2006
    ..Surface tension was regulated in vivo by conditionally expressing surfactant protein (SP)-B in Sftpb-/- mice...
  79. ncbi Polymorphisms of surfactant protein B encoding gene: modifiers of the course of neonatal respiratory distress syndrome?
    Vassiliki Makri
    Department of Paediatrics and Neonatology, University Children s Hospital, Justus Liebig University, Feulgenstrasse 12, 35392 Giessen, Germany
    Eur J Pediatr 161:604-8. 2002
    ..05) and the need for surfactant administration were also higher in group 2 than in group 1 (43.2% versus 72.4%, P < 0.01). Duration of mechanical ventilation and rate of chronic lung disease at 36 weeks were comparable in both groups...
  80. doi Fatal neonatal respiratory failure in an infant with congenital hypothyroidism due to haploinsufficiency of the NKX2-1 gene: alteration of pulmonary surfactant homeostasis
    Barbara Kleinlein
    Kinderklinik Dritter Orden, Munich, Germany
    Arch Dis Child Fetal Neonatal Ed 96:F453-6. 2011
    ..Congenital defects of genes known to disturb surfactant protein and lipid homeostasis (SFTPB, SFTPC, ABCA3) were excluded...
  81. pmc cDNA and deduced amino acid sequence of human pulmonary surfactant-associated proteolipid SPL(Phe)
    S W Glasser
    Proc Natl Acad Sci U S A 84:4007-11. 1987
    ..These proteins, and specifically SPL(Phe), may therefore be useful for synthesis of replacement surfactants for treatment of hyaline membrane disease in newborn infants or of other surfactant-deficient states...
  82. pmc Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice
    J C Clark
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 92:7794-8. 1995
    ..Ablation of the SP-B gene disrupts the routing, storage, and function of surfactant phospholipids and proteins, causing respiratory failure at birth...
  83. ncbi A major deletion in the surfactant protein-B gene causing lethal respiratory distress
    Daniel J Wegner
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, MO 63110, USA
    Acta Paediatr 96:516-20. 2007
    Loss of function mutations in the surfactant protein-B gene (SFTPB) cause lethal neonatal respiratory distress due to reduced or absent expression of mature surfactant protein B (SP-B, encoded in exons 6 and 7)...
  84. ncbi Clinical biological and genetic heterogeneity of the inborn errors of pulmonary surfactant metabolism
    M Tredano
    Service de Biochimie et Biologie Moléculaire, H pital d Enfants Armand Trousseau, Paris, France
    Clin Chem Lab Med 39:90-108. 2001
    ..material is stored within the alveoli, and which represents an autosomal recessive Mendelian entity linked to the SFTPB gene (MIM 1786640)...
  85. pmc Surfactant protein B gene variations enhance susceptibility to squamous cell carcinoma of the lung in German patients
    C Seifart
    Department of Internal Medicine, Division of Respiratory and Critical Care Medicine, Philipps University of Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Br J Cancer 87:212-7. 2002
    ..These results indicate an association of the surfactant protein B intron 4 variants and/or its flanking loci with mechanisms that may enhance lung cancer susceptibility, especially to squamous cell carcinoma of the lung...
  86. ncbi The C/A(-18) polymorphism in the surfactant protein B gene influences transcription and protein levels of surfactant protein B
    Wendy K Steagall
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bldg 10, Rm 6D03, MSC 1590, Bethesda, MD 20892 1590, USA
    Am J Physiol Lung Cell Mol Physiol 292:L448-53. 2007
    ..Differences in amounts of SP-B resulting from the promoter SNP could affect the clinical presentation of pulmonary disease...
  87. ncbi Stage-specific effects of cAMP signaling during distal lung epithelial development
    Jingsong Xu
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital at Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Biol Chem 281:38894-904. 2006
    ..Second, there are cAMP-responsive elements in the heterologous promoters of Sftpb and Sftpa genes...
  88. ncbi Intracellular processing of pulmonary surfactant protein B in an endosomal/lysosomal compartment
    W F Voorhout
    Department of Cell Biology, Medical School, University of Utrecht, The Netherlands
    Am J Physiol 263:L479-86. 1992
    ..These data strongly suggest that precursor SP-B is proteolytically processed to its mature 8-kDa form intracellularly in an endosomal/lysosomal compartment, most probably in multivesicular bodies...
  89. ncbi Genetic determinants of C-reactive protein in COPD
    C P Hersh
    Channing Laboratory, Pulmonary Critical Care Division, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Eur Respir J 28:1156-62. 2006
    ..Two variants in the surfactant protein B (SFTPB) gene were tested for association with CRP levels...
  90. pmc Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 11:30. 2010
    ..One reason may be heterogeneity in disease definition. Unsupervised learning approaches may assist in understanding disease heterogeneity...
  91. ncbi Analysis of 40 sporadic or familial neonatal and pediatric cases with severe unexplained respiratory distress: relationship to SFTPB
    Mohammed Tredano
    Service de Biochimie et Biologie Moléculaire, hôpital d enfants Armand Trousseau AP HP, Paris, France
    Am J Med Genet A 119:324-39. 2003
    We have analyzed surfactant protein B (SP-B) and its encoding gene (SFTPB, MIM 178640) in 40 unrelated pediatric patients with unexplained respiratory distress (URD)...
  92. doi Circulating plasma surfactant protein type B as biological marker of alveolar-capillary barrier damage in chronic heart failure
    Damiano Magrì
    Centro Cardiologico Monzino IRCCS, Istituto di Cardiologia, Universita di Milano, Milan, Italy
    Circ Heart Fail 2:175-80. 2009
    ..The aim of this study was to evaluate the relationship between plasma SPB and both alveolar-capillary diffusion at rest and ventilation versus carbon dioxide production during exercise...
  93. doi Genetic polymorphisms in the surfactant proteins in systemic sclerosis in Japanese: T/T genotype at 1580 C/T (Thr131Ile) in the SP-B gene reduces the risk of interstitial lung disease
    Y Sumita
    Third Department of Internal Medicine, Faculty of Medicine, Shimane University, Shimane, Japan
    Rheumatology (Oxford) 47:289-91. 2008
    ..To investigate the association between single-nucleotide polymorphisms (SNPs) in the pulmonary surfactant protein (SP) genes and the presence or absence of interstitial lung disease (ILD) in SSc patients...
  94. pmc Genetic variants of surfactant proteins A, B, C, and D in bronchopulmonary dysplasia
    J Pavlovic
    Department of Cellular and Molecular Physiology, PSU, Hershey, PA 17033, USA
    Dis Markers 22:277-91. 2006
    ..The data indicate that SP loci are linked to BPD. Studies in different study groups and/or of larger sample size are warranted to confirm these observations and delineate genetic background of BPD subgroups...
  95. ncbi No association between coding polymorphism within Exon 4 of the human surfactant protein B gene and pulmonary function in healthy men
    Stuart M Raleigh
    The Biomedical Research Group, Division of Health and Life Sciences, The University of Northampton, UK
    J Physiol Sci 57:199-202. 2007
    ..We investigated, using spirometry and fluorescence-based PCR, whether this variant influenced pulmonary function in healthy, nonsmoking men. We found no association of pulmonary function with genotype at the rs1130866 locus...
  96. pmc Critical structure-function determinants within the N-terminal region of pulmonary surfactant protein SP-B
    Alicia G Serrano
    Departamento de Bioquimica y Biologia Molecular I, Facultad de Biologia, Universidad Complutense, Madrid, Spain
    Biophys J 90:238-49. 2006
    ....
  97. ncbi Surfactant protein B detection and gene expression in chronic rhinosinusitis
    Bradford A Woodworth
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Laryngoscope 117:1296-301. 2007
    ..Our objective was to detect the presence of SP-B, measure alterations in several forms of chronic rhinosinusitis (CRS), and localize cellular protein expression...
  98. doi Lineage specific evolutionary events on SFTPB gene: Alu recombination-mediated deletion (ARMD), exonization, and alternative splicing events
    Ja Rang Lee
    Pusan National University, Busan, Republic of Korea
    Gene 435:29-35. 2009
    b>SFTPB gene encoding pulmonary surfactant protein has been investigated to have transcript variants related with transposable elements (TEs)...
  99. pmc Deletions within a CA-repeat-rich region of intron 4 of the human SP-B gene affect mRNA splicing
    Zhenwu Lin
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Biochem J 389:403-12. 2005
    ..The results indicate that intron 4 length variants affect SP-B mRNA splicing, and that this may contribute to lung disease...
  100. ncbi Processing of hydrophobic pulmonary surfactant protein B in rat type II cells
    T E Weaver
    Department of Pediatrics, University of Cincinnati, College of Medicine, Ohio 45267
    Am J Physiol 257:L100-8. 1989
    ..These experiments demonstrate complete proteolytic processing of prepro-SP-B to the alveolar Mr 8,000 form by type II epithelial cells in vitro.(ABSTRACT TRUNCATED AT 250 WORDS)..

Research Grants75

  1. SURFACTANT PROTEINS AND RESPIRATORY DISTRESS SYNDROME
    Joanna Floros; Fiscal Year: 2007
    ....
  2. Growth Factor Protection in Acute Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2009
    ..and TGFp interactions that modulate critical gene expression, focusing on the cis-acting elements that control Sftpb promoter transactivation...
  3. EPIDEMIOLOGY OF SURFACTANT PROTEIN-B DEFICIENCY
    FRANCIS COLE; Fiscal Year: 2009
    ..protein B deficiency due to rare, homozygous, loss of function mutations in the surfactant protein 5 gene (SFTPB) invariably causes lethal, neonatal respiratory distress syndrome...
  4. SURFACTANT PROTEINS AND RESPIRATORY DISTRESS SYNDROME
    Joanna Floros; Fiscal Year: 2009
    ....
  5. Genetic Regulation of Surfactant Deficiency
    FRANCIS COLE; Fiscal Year: 2009
    ..human newborn infants have demonstrated that 3 genes are critical for surfactant metabolism: surfactant protein B (SFTPB), surfactant protein C (SFTPC), and an ATP-binding cassette transporter, ABCA3 (ABCA3)...
  6. EPIDEMIOLOGY OF SURFACTANT PROTEIN-B DEFICIENCY
    FRANCIS SESSIONS COLE; Fiscal Year: 2010
    ..variants, allelic heterogeneity, low linkage disequilibrium in pulmonary surfactant metabolic network genes (SFTPB, SFTPC, and ABCA3), and natural selection against variants that disrupt neonatal lung function suggest that rare, ..
  7. EPIDEMIOLOGY OF SURFACTANT PROTEIN-B DEFICIENCY
    F Cole; Fiscal Year: 2007
    ..protein B deficiency due to rare, homozygous, loss of function mutations in the surfactant protein 5 gene (SFTPB) invariably causes lethal, neonatal respiratory distress syndrome...
  8. Genetic Regulation of Surfactant Deficiency
    FRANCIS SESSIONS COLE; Fiscal Year: 2010
    ..human newborn infants have demonstrated that 3 genes are critical for surfactant metabolism: surfactant protein B (SFTPB), surfactant protein C (SFTPC), and an ATP-binding cassette transporter, ABCA3 (ABCA3)...
  9. Growth Factor Protection in Acute Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2007
    ..and TGFbeta interactions that modulate critical gene expression, focusing on the cis-acting elements that control Sftpb promoter transactivation...
  10. In Vivo Metabolism of Pulmonary Surfactant in Infants
    Aaron Hamvas; Fiscal Year: 2005
    ..abstract_text> ..
  11. ABCA3 and Alveolar Homeostasis
    Jeffrey Whitsett; Fiscal Year: 2007
    ....
  12. Role of C/EBPalpha in Cytoprotection and Recovery from Lung Injury
    Machiko Ikegami; Fiscal Year: 2010
    ..Furthermore, the molecular mechanisms, in particular the signaling pathways regulating Cebpa, of recombinant human FGF-7 treatment for acute lung injury will be determined. ..
  13. Genetic Mechanisms of Surfactant Deficiency and Lung Disease
    Lawrence M Nogee; Fiscal Year: 2010
    ..By understanding which genes are involved in causing lung disease and how changes in these genes cause the lung to not function correctly, this may lead to better treatments for some kinds of lung diseases. ..
  14. Asthma Candidate Genes in Alpha 1-Antitrypsin Deficiency
    Dawn DeMeo; Fiscal Year: 2007
    ..The identification of modifying factors of COPD in AAT deficiency may have significant public health relevance to COPD patients without AAT deficiency. ..
  15. Host Genetic Factors in the HIV Virus Life-Cycle and HIV Disease Progression
    Jairam Lingappa; Fiscal Year: 2007
    ....
  16. ABCA3 and Alveolar Homeostasis
    Jeffrey A Whitsett; Fiscal Year: 2010
    ....
  17. Transcriptional Control of Respiratory Epithelial Progenitor Cells
    Jeffrey Whitsett; Fiscal Year: 2009
    ..A Stem Cell Consortium will be established at CCHMC, Univ. of Cincinnati College of Medicine to develop education, training, and research bridging hematopoietic stem cell and pulmonary stem cell biology on our campus. ..
  18. OZONE EFFECTS ON FUNCTION OF SURFACTANT PROTEIN VARIANTS
    Joanna Floros; Fiscal Year: 2007
    ..Knowledge gained may help explain and perhaps link the in vitro data with the human genetic association data, and provide insight in the understanding of the value of the SP-A gene duplication. ..
  19. Transcriptional Control of Respiratory Epithelial Progenitor Cells
    Jeffrey Whitsett; Fiscal Year: 2007
    ..A Stem Cell Consortium will be established at CCHMC, Univ. of Cincinnati College of Medicine to develop education, training, and research bridging hematopoietic stem cell and pulmonary stem cell biology on our campus. ..
  20. Genetic Mechanisms of Surfactant Deficiency and Lung Disease
    Lawrence Nogee; Fiscal Year: 2007
    ..By understanding which genes are involved in causing lung disease and how changes in these genes cause the lung to not function correctly, this may lead to better treatments for some kinds of lung diseases. ..
  21. ROLE OF SURFACTANT PROTEIN D IN SURFACTANT HOMEOSTASIS
    Machiko Ikegami; Fiscal Year: 2006
    ..The intended studies will provide fundamental insights into the role of SP-D in the protection of the lung, as well as into the basic mechanisms determining surfactant homeostasis. ..
  22. SURFACTANT PROTEINS AND RESPIRATORY DISTRESS SYNDROME
    Joanna Floros; Fiscal Year: 1992
    ....
  23. SURFACTANT PROTEINS AND RESPIRATORY DISTRESS SYNDROME
    Joanna Floros; Fiscal Year: 2002
    ..abstract_text> ..
  24. PERINATAL EXPRESSION OF SURFACTANT PROTEIN GENE SP-B
    Jeffrey Whitsett; Fiscal Year: 1993
    ..Further understanding of the role of SP-B in lung function and the mechanisms regulating SP-B may provide insights critical to developing new therapeutic strategies for prevention of lung disease in premature infants...
  25. OZONE EFFECTS ON FUNCTION OF SURFACTANT PROTEIN VARIANTS
    Joanna Floros; Fiscal Year: 2001
    ....
  26. The Role of surfactant protein genetic variants in cyst*
    Joanna Floros; Fiscal Year: 2005
    ..aeruginosa and its clearance, and provide the basis for further consideration of novel therapeutic strategies to treat CF-related lung disease. ..
  27. SURFACTANT PROTEINS AND RESPIRATORY DISTRESS SYNDROME
    Joanna Floros; Fiscal Year: 2010
    ....
  28. OZONE EFFECTS ON FUNCTION OF SURFACTANT PROTEIN VARIANTS
    Joanna Floros; Fiscal Year: 2010
    ..Knowledge gained may help explain and perhaps link the in vitro data with the human genetic association data, and provide insight in the understanding of the value of the SP-A gene duplication. ..