SETD2

Summary

Gene Symbol: SETD2
Description: SET domain containing 2
Alias: HBP231, HIF-1, HIP-1, HSPC069, HYPB, KMT3A, LLS, SET2, p231HBP, histone-lysine N-methyltransferase SETD2, huntingtin interacting protein 1, huntingtin yeast partner B, huntingtin-interacting protein B, lysine N-methyltransferase 3A, protein-lysine N-methyltransferase SETD2
Species: human
Products:     SETD2

Top Publications

  1. Rega S, Stiewe T, Chang D, Pollmeier B, Esche H, Bardenheuer W, et al. Identification of the full-length huntingtin- interacting protein p231HBP/HYPB as a DNA-binding factor. Mol Cell Neurosci. 2001;18:68-79 pubmed
    ..Here, we identified the p231HBP protein as a DNA-binding factor, the C-terminal portion of which has recently been characterized as the ..
  2. Sun X, Wei J, Wu X, Hu M, Wang L, Wang H, et al. Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase. J Biol Chem. 2005;280:35261-71 pubmed
    ..Here we report the structural and functional characterization of the huntingtin interacting protein B (HYPB)...
  3. Passani L, Bedford M, Faber P, McGinnis K, Sharp A, Gusella J, et al. Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis. Hum Mol Genet. 2000;9:2175-82 pubmed
    ..These are revealed to be related spliceosome proteins (HYPA/FBP-11 and HYPC) and a transcription factor (HYPB) that implicate huntingtin in mRNA biogenesis...
  4. Faber P, Barnes G, Srinidhi J, Chen J, Gusella J, MacDonald M. Huntingtin interacts with a family of WW domain proteins. Hum Mol Genet. 1998;7:1463-74 pubmed
    ..Among these, we identified a major interactor class, comprising three distinct WW domain proteins, HYPA, HYPB and HYPC, that bind normal and mutant huntingtin in extracts of HD lymphoblastoid cells...
  5. Li F, Mao G, Tong D, Huang J, Gu L, Yang W, et al. The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell. 2013;153:590-600 pubmed publisher
    ..Cells lacking the H3K36 trimethyltransferase SETD2 display microsatellite instability (MSI) and an elevated spontaneous mutation frequency, characteristic of MMR-..
  6. Fontebasso A, Schwartzentruber J, Khuong Quang D, Liu X, Sturm D, Korshunov A, et al. Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas. Acta Neuropathol. 2013;125:659-69 pubmed publisher
    ..We identified mutations in SETD2, a H3K36 trimethyltransferase, in 15% of pediatric HGGs, a result that was genome-wide significant (FDR = 0.029)...
  7. Duns G, van den Berg E, van Duivenbode I, Osinga J, Hollema H, Hofstra R, et al. Histone methyltransferase gene SETD2 is a novel tumor suppressor gene in clear cell renal cell carcinoma. Cancer Res. 2010;70:4287-91 pubmed publisher
    ..This revealed inactivation of the histone methyltransferase gene SETD2, located on 3p21.31, as a common event in cRCC cells...
  8. Zhu X, He F, Zeng H, Ling S, Chen A, Wang Y, et al. Identification of functional cooperative mutations of SETD2 in human acute leukemia. Nat Genet. 2014;46:287-93 pubmed publisher
    ..KMT2A) gene-rearranged leukemia, we identified a transforming MLL-NRIP3 fusion gene and biallelic mutations in SETD2 (encoding a histone H3K36 methyltransferase)...
  9. Dalgliesh G, Furge K, Greenman C, Chen L, Bignell G, Butler A, et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature. 2010;463:360-3 pubmed publisher
    ..report the identification of inactivating mutations in two genes encoding enzymes involved in histone modification-SETD2, a histone H3 lysine 36 methyltransferase, and JARID1C (also known as KDM5C), a histone H3 lysine 4 demethylase-as ..
  10. Xie P, Tian C, An L, Nie J, Lu K, Xing G, et al. Histone methyltransferase protein SETD2 interacts with p53 and selectively regulates its downstream genes. Cell Signal. 2008;20:1671-8 pubmed publisher
    b>SETD2 (SET domain containing protein 2) is a histone H3K36 trimethyltransferase protein that associates with hyperphosphorylated RNA polymerase II and involves in transcriptional elongation...

Detail Information

Publications62

  1. Rega S, Stiewe T, Chang D, Pollmeier B, Esche H, Bardenheuer W, et al. Identification of the full-length huntingtin- interacting protein p231HBP/HYPB as a DNA-binding factor. Mol Cell Neurosci. 2001;18:68-79 pubmed
    ..Here, we identified the p231HBP protein as a DNA-binding factor, the C-terminal portion of which has recently been characterized as the ..
  2. Sun X, Wei J, Wu X, Hu M, Wang L, Wang H, et al. Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase. J Biol Chem. 2005;280:35261-71 pubmed
    ..Here we report the structural and functional characterization of the huntingtin interacting protein B (HYPB)...
  3. Passani L, Bedford M, Faber P, McGinnis K, Sharp A, Gusella J, et al. Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis. Hum Mol Genet. 2000;9:2175-82 pubmed
    ..These are revealed to be related spliceosome proteins (HYPA/FBP-11 and HYPC) and a transcription factor (HYPB) that implicate huntingtin in mRNA biogenesis...
  4. Faber P, Barnes G, Srinidhi J, Chen J, Gusella J, MacDonald M. Huntingtin interacts with a family of WW domain proteins. Hum Mol Genet. 1998;7:1463-74 pubmed
    ..Among these, we identified a major interactor class, comprising three distinct WW domain proteins, HYPA, HYPB and HYPC, that bind normal and mutant huntingtin in extracts of HD lymphoblastoid cells...
  5. Li F, Mao G, Tong D, Huang J, Gu L, Yang W, et al. The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell. 2013;153:590-600 pubmed publisher
    ..Cells lacking the H3K36 trimethyltransferase SETD2 display microsatellite instability (MSI) and an elevated spontaneous mutation frequency, characteristic of MMR-..
  6. Fontebasso A, Schwartzentruber J, Khuong Quang D, Liu X, Sturm D, Korshunov A, et al. Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas. Acta Neuropathol. 2013;125:659-69 pubmed publisher
    ..We identified mutations in SETD2, a H3K36 trimethyltransferase, in 15% of pediatric HGGs, a result that was genome-wide significant (FDR = 0.029)...
  7. Duns G, van den Berg E, van Duivenbode I, Osinga J, Hollema H, Hofstra R, et al. Histone methyltransferase gene SETD2 is a novel tumor suppressor gene in clear cell renal cell carcinoma. Cancer Res. 2010;70:4287-91 pubmed publisher
    ..This revealed inactivation of the histone methyltransferase gene SETD2, located on 3p21.31, as a common event in cRCC cells...
  8. Zhu X, He F, Zeng H, Ling S, Chen A, Wang Y, et al. Identification of functional cooperative mutations of SETD2 in human acute leukemia. Nat Genet. 2014;46:287-93 pubmed publisher
    ..KMT2A) gene-rearranged leukemia, we identified a transforming MLL-NRIP3 fusion gene and biallelic mutations in SETD2 (encoding a histone H3K36 methyltransferase)...
  9. Dalgliesh G, Furge K, Greenman C, Chen L, Bignell G, Butler A, et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature. 2010;463:360-3 pubmed publisher
    ..report the identification of inactivating mutations in two genes encoding enzymes involved in histone modification-SETD2, a histone H3 lysine 36 methyltransferase, and JARID1C (also known as KDM5C), a histone H3 lysine 4 demethylase-as ..
  10. Xie P, Tian C, An L, Nie J, Lu K, Xing G, et al. Histone methyltransferase protein SETD2 interacts with p53 and selectively regulates its downstream genes. Cell Signal. 2008;20:1671-8 pubmed publisher
    b>SETD2 (SET domain containing protein 2) is a histone H3K36 trimethyltransferase protein that associates with hyperphosphorylated RNA polymerase II and involves in transcriptional elongation...
  11. Carvalho S, Raposo A, Martins F, Grosso A, Sridhara S, Rino J, et al. Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription. Nucleic Acids Res. 2013;41:2881-93 pubmed publisher
    Histone H3 of nucleosomes positioned on active genes is trimethylated at Lys36 (H3K36me3) by the SETD2 (also termed KMT3A/SET2 or HYPB) methyltransferase...
  12. Li M, Phatnani H, Guan Z, Sage H, Greenleaf A, Zhou P. Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1. Proc Natl Acad Sci U S A. 2005;102:17636-41 pubmed
    ..The Set2 histone methyltransferase from yeast was recently shown to bind the PCTD of elongating RNA polymerase II by means ..
  13. Yoh S, Lucas J, Jones K. The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation. Genes Dev. 2008;22:3422-34 pubmed publisher
    ..Here we show that Iws1 also recruits the HYPB/Setd2 histone methyltransferase to the RNAPII elongation complex and is required for H3K36 trimethylation (H3K36me3) ..
  14. Al Sarakbi W, Sasi W, Jiang W, Roberts T, Newbold R, Mokbel K. The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters. BMC Cancer. 2009;9:290 pubmed publisher
    SET domain containing protein 2 (SETD2) is a histone methyltransferase that is involved in transcriptional elongation. There is evidence that SETD2 interacts with p53 and selectively regulates its downstream genes...
  15. Newbold R, Mokbel K. Evidence for a tumour suppressor function of SETD2 in human breast cancer: a new hypothesis. Anticancer Res. 2010;30:3309-11 pubmed
    SET domain containing protein 2 (SETD2) is a histone methyltransferase that is involved in transcriptional elongation. We previously demonstrated SETD2 to be a potential tumour suppressor gene in breast cancer...
  16. Xu K, Sun X, Benderro G, Tsipis C, Lamanna J. Gender differences in hypoxic acclimatization in cyclooxygenase-2-deficient mice. Physiol Rep. 2017;5: pubmed publisher
    ....
  17. Kim J, Choi D, Min J, Kang I, Kim J, Kim S, et al. VBP1 represses cancer metastasis by enhancing HIF-1α degradation induced by pVHL. FEBS J. 2017;: pubmed publisher
    ..These findings suggest that VBP1 is a bona fide tumor suppressor protein associated with HIF-1α regulation. This article is protected by copyright. All rights reserved...
  18. Giaccia A. A New Chromatin-Cytoskeleton Link in Cancer. Mol Cancer Res. 2016;14:1173-1175 pubmed
    The set domain containing 2 (SETD2) histone methyltransferase, located at 3p2, specifically trimethylates lysine 36 of histone H3 (H3K36me3)...
  19. Bartoszewski R, Serocki M, Janaszak Jasiecka A, Bartoszewska S, Kochan Jamrozy K, Piotrowski A, et al. miR-200b downregulates Kruppel Like Factor 2 (KLF2) during acute hypoxia in human endothelial cells. Eur J Cell Biol. 2017;96:758-766 pubmed publisher
    ..Moreover, we provide a viable approach for differentiating direct from indirect miRNA effects in order to untangle the complexity of individual miRNA networks. ..
  20. Zoccola D, Morain J, Pages G, Caminiti Segonds N, Giuliano S, Tambutte S, et al. Structural and functional analysis of coral Hypoxia Inducible Factor. PLoS ONE. 2017;12:e0186262 pubmed publisher
    ..This study shows the strong conservation of molecular mechanisms involved in adaptation to O2 concentration between Cnidarians and Mammals whose ancestors diverged about 1,200-1,500 million years ago...
  21. Hahne M, Schumann P, Mursell M, Strehl C, Hoff P, Buttgereit F, et al. Unraveling the role of hypoxia-inducible factor (HIF)-1α and HIF-2α in the adaption process of human microvascular endothelial cells (HMEC-1) to hypoxia: Redundant HIF-dependent regulation of macrophage migration inhibitory factor. Microvasc Res. 2018;116:34-44 pubmed publisher
    ..These findings open new possibilities for therapeutic approaches by specifically targeting the HIF-1 and HIF-2 or their target MIF. ..
  22. Lin C, Liu T, Lee M, Yang S, Tsao T. Independent Prognostic Value of Hypoxia-inducible Factor 1-alpha Expression in Small Cell Lung Cancer. Int J Med Sci. 2017;14:785-790 pubmed publisher
    ..003). In conclusion, we have provided evidence that HIF-1α expression has significant value in predicting survival of patients with SCLC and is an independent prognostic factor beyond ECOG performance and metastasis status. ..
  23. Güntert T, Gassmann M, Ogunshola O. Temporal Rac1 - HIF-1 crosstalk modulates hypoxic survival of aged neurons. Brain Res. 2016;1642:298-307 pubmed publisher
    ..Thus hypoxia-activated Rac1 is critical for neuronal HIF-1α stabilization and survival during oxygen deprivation via integration of complex signaling cascades...
  24. Passos G, Camargo J, Ferrari K, Saad M, de Mattos A, Reis L. Intravesical Thalidomide boosts bacillus Calmette-Guérin (BCG) in non-muscle invasive bladder cancer treatment. Med Oncol. 2017;35:3 pubmed publisher
    ..Intravesical BCG-Thalidomide might represent a significant increment in NMIBC treatment, suggesting p70S6K1, HIF-1 and VEGF as potential molecular target candidates in a clinically relevant immune competent NMIBC model. ..
  25. Lee Y, Lee J, Kim S, Lee Y. Synthesis and biological evaluation of 1,2-dithiol-3-thiones and pyrrolo[1,2-a]pyrazines as novel hypoxia inducible factor-1 (HIF-1) inhibitor. Bioorg Med Chem. 2016;24:2843-51 pubmed publisher
    ..Among the synthesized, benzyl-substituted pyrrolo[1,2-a]pyrazine 2g most potently inhibited HIF-1α protein accumulation (81% at 10μM) and VEGF, GLUT-1 transcription (77% and 92% at 10μM, respectively)...
  26. Ho T, Choueiri T, Wang K, Karam J, Chalmers Z, Frampton G, et al. Correlation Between Molecular Subclassifications of Clear Cell Renal Cell Carcinoma and Targeted Therapy Response. Eur Urol Focus. 2016;2:204-209 pubmed publisher
    ..The most common GAs detected in this series were in VHL (70%), PBRM1 (48%), SETD2 (32%), TSC1 (29%), MLL (19%), TERT (16%), ARID1B (16%), and KDM5C (16%)...
  27. Maier A, Wu H, Cordasic N, Oefner P, Dietel B, Thiele C, et al. Hypoxia-inducible protein 2 Hig2/Hilpda mediates neutral lipid accumulation in macrophages and contributes to atherosclerosis in apolipoprotein E-deficient mice. FASEB J. 2017;31:4971-4984 pubmed publisher
    ..Dietel, B., Thiele, C., Weidemann, A., Eckardt, K.-U., Warnecke, C. Hypoxia-inducible protein 2 Hig2/Hilpda mediates neutral lipid accumulation in macrophages and contributes to atherosclerosis in apolipoprotein E-deficient mice. ..
  28. Simon J, Hacker K, Singh D, Brannon A, Parker J, Weiser M, et al. Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects. Genome Res. 2014;24:241-50 pubmed publisher
    ..cell renal cell carcinoma (ccRCC), three of the five commonly mutated genes encode the chromatin regulators PBRM1, SETD2, and BAP1...
  29. Möllerherm H, Meier K, Schmies K, Fuhrmann H, Naim H, von Köckritz Blickwede M, et al. Differentiation and Functionality of Bone Marrow-Derived Mast Cells Depend on Varying Physiologic Oxygen Conditions. Front Immunol. 2017;8:1665 pubmed publisher
    ..These results show for the first time that physioxia substantially affect maturation and the properties of MCs and highlight the need to study their function under physiologically relevant oxygen conditions...
  30. Saito M, Fujiwara Y, Asao T, Honda T, Shimada Y, Kanai Y, et al. The genomic and epigenomic landscape in thymic carcinoma. Carcinogenesis. 2017;38:1084-1091 pubmed publisher
    ..We identified recurrent somatic mutations in TET2, CYLD, SETD2, TP53, FBXW7, HRAS and RB1, and no mutations in GTF2I, supporting the hypothesis that TC and thymoma are ..
  31. Li B, Jackson J, Simon M, Fleharty B, Gogol M, Seidel C, et al. Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription. J Biol Chem. 2009;284:7970-6 pubmed publisher
    ..Transcription analysis and genome-wide histone modification studies on these mutants suggested that K36me2 is sufficient to target Rpd3S in vivo, thereby maintaining a functional Set2-Rpd3S pathway.
  32. Li L, Wang Y. Cross-talk between the H3K36me3 and H4K16ac histone epigenetic marks in DNA double-strand break repair. J Biol Chem. 2017;292:11951-11959 pubmed publisher
    ..was abolished in cells upon depletion of the histone methyltransferase gene SET-domain containing 2 (SETD2) and the ensuing loss of H3K36me3...
  33. Påhlman S, Mohlin S. Hypoxia and hypoxia-inducible factors in neuroblastoma. Cell Tissue Res. 2017;: pubmed publisher
    ....
  34. Semenza G. A compendium of proteins that interact with HIF-1α. Exp Cell Res. 2017;356:128-135 pubmed publisher
    ..This review provides a compendium of proteins that interact with the HIF-1α subunit, many of which regulate HIF-1 activity in either an O2-dependent or O2-independent manner. ..
  35. Fitzpatrick S, Fabian Z, Schaible B, Lenihan C, Schwarzl T, Rodriguez J, et al. Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner. Biochem Biophys Res Commun. 2016;474:579-586 pubmed publisher
    ..This study provides new information relating to the possible mechanism of therapeutic action of hydroxylase inhibitors that has been reported in pre-clinical models of intestinal and hepatic disease...
  36. Fujiki R, Chikanishi T, Hashiba W, Ito H, Takada I, Roeder R, et al. GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. Nature. 2009;459:455-9 pubmed publisher
    ..Thus, nuclear MLL5 GlcNAcylation triggers cell lineage determination of HL60 through activation of its HKMT activity. ..
  37. D Gama A, Pochareddy S, Li M, Jamuar S, Reiff R, Lam A, et al. Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms. Neuron. 2015;88:910-917 pubmed publisher
    ..028) compared to controls, with recurrent deleterious mutations in ARID1B, SCN1A, SCN2A, and SETD2, suggesting these mutations contribute to ASD risk...
  38. Hakimi A, Ostrovnaya I, Reva B, Schultz N, Chen Y, Gonen M, et al. Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network. Clin Cancer Res. 2013;19:3259-67 pubmed publisher
    To investigate the impact of newly identified chromosome 3p21 epigenetic tumor suppressors PBRM1, SETD2, and BAP1 on cancer-specific survival (CSS) of 609 patients with clear cell renal cell carcinoma (ccRCC) from 2 distinct cohorts...
  39. Niu L, Pei D, Morris M, Jiao K, Huang X, Primus C, et al. Mineralogenic characteristics of osteogenic lineage-committed human dental pulp stem cells following their exposure to a discoloration-free calcium aluminosilicate cement. Dent Mater. 2016;32:1235-47 pubmed publisher
    ..The present study examined the effects of this experimental cement (Quick-Set2) on the mineralogenic characteristics of osteogenic lineage-committed human dental pulp stem cells (hDPSCs), by ..
  40. Moon Y, Lee S, Park B, Park H. Distinct hypoxic regulation of preadipocyte factor-1 (Pref-1) in preadipocytes and mature adipocytes. Biochim Biophys Acta. 2018;1865:334-342 pubmed publisher
    ..Interestingly, long term (35weeks) HFD increased Pref-1 in serum but not in obese adipose tissues. This study suggests that Pref-1 is an endocrine factor which is synergistically increased by obesity and age. ..
  41. Manley B, Zabor E, Casuscelli J, Tennenbaum D, Redzematovic A, Becerra M, et al. Integration of Recurrent Somatic Mutations with Clinical Outcomes: A Pooled Analysis of 1049 Patients with Clear Cell Renal Cell Carcinoma. Eur Urol Focus. 2016;: pubmed publisher
    ..005) remained significant when SSIGN score was included. SETD2 mutations (q=0.047) were associated with decreased RFS in multivariable models, including models with SSIGN score...
  42. Gu Q, Wang Z, Sun X, Ji T, Huang H, Yang Y, et al. FvSet2 regulates fungal growth, pathogenicity, and secondary metabolism in Fusarium verticillioides. Fungal Genet Biol. 2017;107:24-30 pubmed publisher
    ..However, the function of H3K36me in filamentous fungi is largely unknown. Set2 is the sole lysine histone methyltransferase (KHMTase) enzyme responsible for the methylation of H3K36 in ..
  43. Zheng W, Ibáñez G, Wu H, Blum G, Zeng H, Dong A, et al. Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2. J Am Chem Soc. 2012;134:18004-14 pubmed publisher
    ..In this work, we demonstrated the feasibility of such an approach by identifying the inhibitors of SETD2. N-propyl sinefungin (Pr-SNF) was shown to interact preferentially with SETD2 by matching the distinct transition-..
  44. Dobrynin G, McAllister T, Leszczynska K, Ramachandran S, Krieg A, Kawamura A, et al. KDM4A regulates HIF-1 levels through H3K9me3. Sci Rep. 2017;7:11094 pubmed publisher
    ..This suggests that KDM4A can enhance the function of HIF-1α by increasing the total available protein to counteract any residual activity of prolyl hydroxylases. ..
  45. Cheung C, Anderson D, Brace R. Transport-associated pathway responses in ovine fetal membranes to changes in amniotic fluid dynamics. Physiol Rep. 2017;5: pubmed publisher
    ..Further, our results are consistent with the concept that the amnion is the rate-limiting layer for amniotic fluid transport. ..
  46. Zepeda Orozco D, Wen H, Hamilton B, Raikwar N, Thomas C. EGF regulation of proximal tubule cell proliferation and VEGF-A secretion. Physiol Rep. 2017;5: pubmed publisher
    ....
  47. Zhu K, Lei P, Ju L, Wang X, Huang K, Yang B, et al. SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing. Nucleic Acids Res. 2017;45:92-105 pubmed publisher
    ..b>SETD2 is a major H3K36 trimethyltransferase, which has been implicated as a tumor suppressor in mammals...
  48. Dietz S, Sultmann H, Du Y, Reisinger E, Riediger A, Volckmar A, et al. Patient-specific molecular alterations are associated with metastatic clear cell renal cell cancer progressing under tyrosine kinase inhibitor therapy. Oncotarget. 2017;8:74049-74057 pubmed publisher
    ..genetic concordance between primary and secondary tumor sites with private mutations in FLT4, MTOR, ITGA5, SETD2, PBRM1, and BRCA1 on progression...
  49. Tong M, Gonzalez Navarrete H, Kirchberg T, Gotama B, Yalcin E, Kay J, et al. Ethanol-Induced White Matter Atrophy Is Associated with Impaired Expression of Aspartyl-Asparaginyl-β-Hydroxylase (ASPH) and Notch Signaling in an Experimental Rat Model. J Drug Alcohol Res. 2017;6: pubmed publisher
    ..These findings link ethanol-induced WM atrophy to inhibition of ASPH expression and signaling through Notch networks, including HIF-1α...
  50. Yoshii Y, Yoshimoto M, Matsumoto H, Furukawa T, Zhang M, Inubushi M, et al. 64Cu-ATSM internal radiotherapy to treat tumors with bevacizumab-induced vascular decrease and hypoxia in human colon carcinoma xenografts. Oncotarget. 2017;8:88815-88826 pubmed publisher
    ..sup>64Cu-ATSM therapy could represent a novel approach as an add-on to antiangiogenic therapy...
  51. Kazi A, Gilani R, Schech A, Chumsri S, Sabnis G, Shah P, et al. Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer. Breast Cancer Res. 2014;16:R15 pubmed publisher
    ..This study investigated the potential role of transcription factor hypoxia inducible factor 1 (HIF-1) in acquired AI resistance, and its regulation by HER2...
  52. Shimoda L, Manalo D, Sham J, Semenza G, Sylvester J. Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia. Am J Physiol Lung Cell Mol Physiol. 2001;281:L202-8 pubmed
    ..Thus partial deficiency of HIF-1alpha is sufficient to impair hypoxia-induced depolarization, reduction of K+ current density, and PASMC hypertrophy...
  53. Yang C, Xu J, Yan D, Liu B, Liu K, Huang F. Mangiferin ameliorates insulin resistance by inhibiting inflammation and regulatiing adipokine expression in adipocytes under hypoxic condition. Chin J Nat Med. 2017;15:664-673 pubmed publisher
    ..These results showed that mangiferin could not only improve the damaged insulin signaling pathway in hypoxic adipocytes, but also ameliorate inflammatory reaction and insulin resistance caused by hypoxia...
  54. Mehdi A, Riazalhosseini Y. Epigenome Aberrations: Emerging Driving Factors of the Clear Cell Renal Cell Carcinoma. Int J Mol Sci. 2017;18: pubmed publisher
    ..that mutations of genes coding for epigenome modifiers and chromatin remodelers, including PBRM1, SETD2 and BAP1, are the most common somatic genetic abnormalities after VHL mutations in these tumors...
  55. Zheng X, Narayanan S, Zheng X, Luecke Johansson S, Gradin K, Catrina S, et al. A Notch-independent mechanism contributes to the induction of Hes1 gene expression in response to hypoxia in P19 cells. Exp Cell Res. 2017;358:129-139 pubmed publisher
    ..These results suggest a Notch-independent mechanism where HIF-1 and GABP contribute to the upregulation of Hes1 gene expression in response to hypoxia. ..
  56. Mey A, Jiménez J, Michel J. Impact of domain knowledge on blinded predictions of binding energies by alchemical free energy calculations. J Comput Aided Mol Des. 2018;32:199-210 pubmed publisher
    ..The best performing protocols on D3R set1 and set2 were comparable or superior to predictions made on the basis of analysis of literature structure activity ..
  57. Suzuki S, Kato H, Suzuki Y, Chikashige Y, Hiraoka Y, Kimura H, et al. Histone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast. Nucleic Acids Res. 2016;44:4147-62 pubmed publisher
    In budding yeast, Set2 catalyzes di- and trimethylation of H3K36 (H3K36me2 and H3K36me3) via an interaction between its Set2-Rpb1 interaction (SRI) domain and C-terminal repeats of RNA polymerase II (Pol2) phosphorylated at Ser2 and Ser5 (..
  58. Ariazi J, Duffy K, Adams D, Fitch D, Luo L, Pappalardi M, et al. Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia. J Pharmacol Exp Ther. 2017;363:336-347 pubmed publisher
    ..GSK1278863 is currently in phase 3 clinical trials for treatment of anemia in patients with chronic kidney disease. ..
  59. Moffitt A, Ondrejka S, McKinney M, Rempel R, Goodlad J, Teh C, et al. Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2. J Exp Med. 2017;214:1371-1386 pubmed publisher
    ..Here, we defined the genetic landscape of EATL through whole-exome sequencing of 69 EATL tumors. SETD2 was the most frequently silenced gene in EATL (32% of cases)...
  60. Lin X, Tang L, Yang J, Xu W. HIF-1 regulates insect lifespan extension by inhibiting c-Myc-TFAM signaling and mitochondrial biogenesis. Biochim Biophys Acta. 2016;1863:2594-2603 pubmed publisher
    ..Thus, the HIF-1α-c-Myc-TFAM signaling pathway participates in the regulation of mitochondrial activity for insect diapause or lifespan extension. ..
  61. Tlemsani C, Luscan A, Leulliot N, Bieth E, Afenjar A, Baujat G, et al. SETD2 and DNMT3A screen in the Sotos-like syndrome French cohort. J Med Genet. 2016;53:743-751 pubmed publisher
    ..Recently, mutations of the SETD2 and DNMT3A genes were identified in patients exhibiting only some Sotos syndrome features...
  62. Chen Z, Raghoonundun C, Chen W, Zhang Y, Tang W, Fan X, et al. SETD2 indicates favourable prognosis in gastric cancer and suppresses cancer cell proliferation, migration, and invasion. Biochem Biophys Res Commun. 2018;498:579-585 pubmed publisher
    SET domain containing protein 2 (SETD2, also known as HYPB) is a 230-kD protein which is located at cytogenetic band p21.31 of chromosome 3. SETD2 is usually transformed or eradicated in multiple forms of tumours in humans...