seryl tRNA synthetase

Summary

Gene Symbol: seryl tRNA synthetase
Description: seryl-tRNA synthetase
Alias: NEDMAS, SERRS, SERS, serine--tRNA ligase, cytoplasmic, serine tRNA ligase 1, cytoplasmic, seryl-tRNA synthetase, cytoplasmic, seryl-tRNA(Ser/Sec) synthetase
Species: human
Products:     seryl tRNA synthetase

Top Publications

  1. Herzog W, Müller K, Huisken J, Stainier D. Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development. Circ Res. 2009;104:1260-6 pubmed publisher
    ..These analyses of zebrafish and human endothelial cells reveal a new noncanonical function of Sars in endothelial development. ..
  2. Belostotsky R, Ben Shalom E, Rinat C, Becker Cohen R, Feinstein S, Zeligson S, et al. Mutations in the mitochondrial seryl-tRNA synthetase cause hyperuricemia, pulmonary hypertension, renal failure in infancy and alkalosis, HUPRA syndrome. Am J Hum Genet. 2011;88:193-200 pubmed publisher
  3. Xu X, Shi Y, Yang X. Crystal structure of human Seryl-tRNA synthetase and Ser-SA complex reveals a molecular lever specific to higher eukaryotes. Structure. 2013;21:2078-86 pubmed publisher
    Seryl-tRNA synthetase (SerRS), an essential enzyme for translation, also regulates vascular development. This "gain-of-function" has been linked to the UNE-S domain added to vertebrate SerRS during evolution...
  4. Magrini A, Grana M, Vicentini L. [Chemical, physical and biological risks in law enforcement]. G Ital Med Lav Ergon. 2014;36:382-91 pubmed
    ..Another important aspect is the education and training of staff, as in emergency situations should be able to take protective measures as quickly as possible. ..
  5. Bayrakdar F, Altas A, Korukluoglu G, Topal S. [Molecular diagnosis and phylogenetic analysis of the first MERS case in Turkey]. Mikrobiyol Bul. 2015;49:414-22 pubmed
  6. Dai W, White R, Liu J, Liu H. Seryl-tRNA synthetase-mediated essential amino acids regulate β-casein synthesis via cell proliferation and mammalian target of rapamycin (mTOR) signaling pathway in bovine mammary epithelial cells. J Dairy Sci. 2018;101:10456-10468 pubmed publisher
    ..The results indicated that SARS stimulated the mTOR signaling pathway when EAA were present, enhanced EAA-stimulated cell proliferation, and contributed to increased β-casein production in BMEC. ..
  7. Warnes S, Little Z, Keevil C. Human Coronavirus 229E Remains Infectious on Common Touch Surface Materials. MBio. 2015;6:e01697-15 pubmed publisher
    ..Incorporation of copper alloy surfaces in conjunction with effective cleaning regimens and good clinical practice could help to control transmission of respiratory coronaviruses, including MERS and SARS. ..
  8. Hu J, Tian J, Li F, Xue B, Hu J, Cheng X, et al. Clone and functional analysis of Seryl-tRNA synthetase and Tyrosyl-tRNA synthetase from silkworm, Bombyx mori. Sci Rep. 2017;7:41563 pubmed publisher
    ..In this study, the seryl-tRNA synthetase (SerRS) and tyrosyl-tRNA synthetase (TyrRS) genes from silkworm were cloned...
  9. Case J, Ashbrook A, Dermody T, Denison M. Mutagenesis of S-Adenosyl-l-Methionine-Binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing Requirements for Genome Translation and Resistance to Innate Immunity. J Virol. 2016;90:7248-7256 pubmed publisher
    ..Our data support the idea that coronavirus RNA capping could be targeted for development of antiviral therapeutics. ..

More Information

Publications149 found, 100 shown here

  1. Minakshi R, Padhan K, Rehman S, Hassan M, Ahmad F. The SARS Coronavirus 3a protein binds calcium in its cytoplasmic domain. Virus Res. 2014;191:180-3 pubmed publisher
    ..Our results strongly suggest that the cytoplasmic domain of the 3a protein of SARS-CoV binds calcium in vitro, causing a change in protein conformation. ..
  2. Wang Y, Liu L. The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Functions as a Novel Cytosolic Pathogen-Associated Molecular Pattern To Promote Beta Interferon Induction via a Toll-Like-Receptor-Related TRAF3-Independent Mechanism. MBio. 2016;7:e01872-15 pubmed publisher
    ..Thus, the results indicate for the first time that SARS-CoV M protein may function as a cytosolic PAMP to stimulate IFN-β production by activating a TLR-related TRAF3-independent signaling cascade. ..
  3. Lin C, Lee M, Lin J, Lin M, Chueh F, Yu C, et al. Crude extract of Rheum palmatum L. Induces cell cycle arrest S phase and apoptosis through mitochondrial-dependent pathways in U-2 OS human osteosarcoma cells. Environ Toxicol. 2016;31:957-69 pubmed publisher
    ..These results indicate that CERP has anticancer effects in vitro and provide the foundation for in vivo studies of animal models of osteosarcoma. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 957-969, 2016. ..
  4. Deng X, StJohn S, Osswald H, O Brien A, Banach B, Sleeman K, et al. Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance. J Virol. 2014;88:11886-98 pubmed publisher
    ..Overall, our study provides the first analysis of the low barrier but high cost of resistance to a CoV 3CLpro inhibitor, which will facilitate the further development of protease inhibitors as anti-coronavirus therapeutics. ..
  5. Bleau C, Filliol A, Samson M, Lamontagne L. Brain Invasion by Mouse Hepatitis Virus Depends on Impairment of Tight Junctions and Beta Interferon Production in Brain Microvascular Endothelial Cells. J Virol. 2015;89:9896-908 pubmed publisher
    ..We provide evidence that production of IFN-β by BMECs during CoV infection may prevent BBB breakdown and brain viral invasion. ..
  6. Ou X, Zheng W, Shan Y, Mu Z, Dominguez S, Holmes K, et al. Identification of the Fusion Peptide-Containing Region in Betacoronavirus Spike Glycoproteins. J Virol. 2016;90:5586-5600 pubmed publisher
    ..Our findings identify a potential new target for development of drugs against CoVs. ..
  7. Eggers M, Koburger Janssen T, Eickmann M, Zorn J. In Vitro Bactericidal and Virucidal Efficacy of Povidone-Iodine Gargle/Mouthwash Against Respiratory and Oral Tract Pathogens. Infect Dis Ther. 2018;7:249-259 pubmed publisher
    ..23% PVP-I and may provide a protective oropharyngeal hygiene measure for individuals at high risk of exposure to oral and respiratory pathogens. Mundipharma Research GmbH & Co. KG (MRG). ..
  8. Stewart H, Brown K, Dinan A, Irigoyen N, Snijder E, Firth A. Transcriptional and Translational Landscape of Equine Torovirus. J Virol. 2018;92: pubmed publisher
    ..Together these results highlight the similarities and differences between this domestic animal virus and related pathogens of humans and livestock. ..
  9. Hsu S. Compounds Derived from Epigallocatechin-3-Gallate (EGCG) as a Novel Approach to the Prevention of Viral Infections. Inflamm Allergy Drug Targets. 2015;14:13-8 pubmed
  10. Irigoyen N, Firth A, Jones J, Chung B, Siddell S, Brierley I. High-Resolution Analysis of Coronavirus Gene Expression by RNA Sequencing and Ribosome Profiling. PLoS Pathog. 2016;12:e1005473 pubmed publisher
    ..Contrary to expectations, ribosomes were not found to pause at the ribosomal frameshift site. To our knowledge this is the first application of ribosome profiling to an RNA virus. ..
  11. Pauly M, Pir J, Loesch C, Sausy A, Snoeck C, Hübschen J, et al. Novel Alphacoronaviruses and Paramyxoviruses Cocirculate with Type 1 and Severe Acute Respiratory System (SARS)-Related Betacoronaviruses in Synanthropic Bats of Luxembourg. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..We suggest that this gap in disease surveillance should be addressed, since we show here that synanthropic bats host viruses that may be able to cross the species barrier. ..
  12. Shirato K, Kanou K, Kawase M, Matsuyama S. Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry. J Virol. 2017;91: pubmed
    ..Therefore, therapeutic agents for coronavirus-mediated diseases, such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), should target cell surface TMPRSS2 rather than endosomal cathepsin. ..
  13. Goldstein S, Thornbrough J, Zhang R, Jha B, Li Y, Elliott R, et al. Lineage A Betacoronavirus NS2 Proteins and the Homologous Torovirus Berne pp1a Carboxy-Terminal Domain Are Phosphodiesterases That Antagonize Activation of RNase L. J Virol. 2017;91: pubmed publisher
    ..Thus, this work demonstrates that a potent antagonist of host antiviral defenses is encoded by multiple and diverse viruses within the family Coronaviridae, presenting a possible broad-spectrum therapeutic target. ..
  14. Phillips J, Gallagher T, Weiss S. Neurovirulent Murine Coronavirus JHM.SD Uses Cellular Zinc Metalloproteases for Virus Entry and Cell-Cell Fusion. J Virol. 2017;91: pubmed publisher
  15. Maršavelski A, Lesjak S, Močibob M, Weygand Đurašević I, Tomić S. A single amino acid substitution affects the substrate specificity of the seryl-tRNA synthetase homologue. Mol Biosyst. 2014;10:3207-16 pubmed publisher
    ..glycine:[carrier protein] ligase 1 (Bj Gly:CP ligase 1), a homologue of methanogenic type seryl-tRNA synthetase (SerRS) is an intriguing enzyme whose physiological role is not yet known...
  16. Rodhain F. [Bats and Viruses: complex relationships]. Bull Soc Pathol Exot. 2015;108:272-89 pubmed publisher
    ..Clearly, a great deal of additional work is needed to document the roles of bats in the natural history of viruses. ..
  17. Mackay I, Arden K. MERS coronavirus: diagnostics, epidemiology and transmission. Virol J. 2015;12:222 pubmed publisher
    ..While the basic virology of MERS-CoV has advanced over the past three years, understanding of the interplay between camel, environment, and human remains limited. ..
  18. Zhang M, Li X, Deng Z, Chen Z, Liu Y, Gao Y, et al. Structural Biology of the Arterivirus nsp11 Endoribonucleases. J Virol. 2017;91: pubmed
    ..The three structures solved in this study provide new insight into the molecular mechanisms of this crucial protein family and will benefit the development of new treatments against these deadly viruses. ..
  19. Zhang R, Li Y, Cowley T, Steinbrenner A, Phillips J, Yount B, et al. The nsp1, nsp13, and M proteins contribute to the hepatotropism of murine coronavirus JHM.WU. J Virol. 2015;89:3598-609 pubmed publisher
    ..Understanding virulence determinants will aid in the design of vaccines and antiviral strategies. ..
  20. Chen J, Wu D, Li T, Yang K, Cheng L, Zhou Z, et al. Arylurea Derivatives: A Class of Potential Cancer Targeting Agents. Curr Top Med Chem. 2017;17:3099-3130 pubmed publisher
    ..This review focuses on the Structure-Activity Relationships (SARs) of these arylureas. The structural evolution and current status of some typical anti-cancer agents used in clinic and/or in clinical trials are emphasized...
  21. Zhou Y, Vedantham P, Lu K, Agudelo J, Carrion R, Nunneley J, et al. Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Res. 2015;116:76-84 pubmed publisher
  22. Wang Y, Sun Y, Wu A, Xu S, Pan R, Zeng C, et al. Coronavirus nsp10/nsp16 Methyltransferase Can Be Targeted by nsp10-Derived Peptide In Vitro and In Vivo To Reduce Replication and Pathogenesis. J Virol. 2015;89:8416-27 pubmed publisher
    ..This work makes it possible to develop broad-spectrum peptide inhibitors by targeting the nsp16/nsp10 2'-O-MTase of coronaviruses. ..
  23. Maringer K, Fernandez Sesma A. Message in a bottle: lessons learned from antagonism of STING signalling during RNA virus infection. Cytokine Growth Factor Rev. 2014;25:669-79 pubmed publisher
  24. He B, Huang X, Zhang F, Tan W, Matthijnssens J, Qin S, et al. Group A Rotaviruses in Chinese Bats: Genetic Composition, Serology, and Evidence for Bat-to-Human Transmission and Reassortment. J Virol. 2017;91: pubmed publisher
    ..Serological investigation has also indicated that RVA infection in bats is far more prevalent than expected based on the detection of viral RNA. ..
  25. Vijay R, Hua X, Meyerholz D, Miki Y, Yamamoto K, Gelb M, et al. Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection. J Exp Med. 2015;212:1851-68 pubmed publisher
  26. Wong H, Kumar P, Tay F, Moreau D, Liu D, Bard F. Genome-Wide Screen Reveals Valosin-Containing Protein Requirement for Coronavirus Exit from Endosomes. J Virol. 2015;89:11116-28 pubmed publisher
    ..The several host factors identified in this study may provide directions for future research on targeted therapeutics. ..
  27. Fu X, Cheng Z, Yu J, Choo P, Chen L, Choo J. A SERS-based lateral flow assay biosensor for highly sensitive detection of HIV-1 DNA. Biosens Bioelectron. 2016;78:530-537 pubmed publisher
    ..To resolve these problems associated with LF strips, we developed a novel surface-enhanced Raman scattering (SERS)-based LF assay for the quantitative analysis of a specific biomarker in the low concentration range...
  28. Cox L, Sanchez Borges M, Lockey R. World Allergy Organization Systemic Allergic Reaction Grading System: Is a Modification Needed?. J Allergy Clin Immunol Pract. 2017;5:58-62.e5 pubmed publisher
    ..The universal use of the proposed modified SAR grading system will allow for better safety comparisons across different venues and treatment protocols. ..
  29. Hou R, Tong M, Gao W, Wang L, Yang T, He L. Investigation of degradation and penetration behaviors of dimethoate on and in spinach leaves using in situ SERS and LC-MS. Food Chem. 2017;237:305-311 pubmed publisher
    ..and penetration behaviors of the organophosphate insecticide dimethoate applied on spinach leaves, in situ SERS and LC-MS methods were used to detect dimethoate residue on&in spinach leaves picked on different days after ..
  30. Lin M, Moses D, Hsieh C, Cheng S, Chen Y, Sun C, et al. Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes. Antiviral Res. 2018;150:155-163 pubmed publisher
  31. Caires A, Vaz R, Fantini C, Ladeira L. Highly sensitive and simple SERS substrate based on photochemically generated carbon nanotubes-gold nanorods hybrids. J Colloid Interface Sci. 2015;455:78-82 pubmed publisher
    ..Measurements of surface-enhanced Raman scattering (SERS) through the effect "coffee ring" in visible and near infrared (NIR) show high sensitivity with detection of ..
  32. Huang S, Lee T, Lin Y, Wan L, Lai C, Lin C. Phage display technique identifies the interaction of severe acute respiratory syndrome coronavirus open reading frame 6 protein with nuclear pore complex interacting protein NPIPB3 in modulating Type I interferon antagonism. J Microbiol Immunol Infect. 2017;50:277-285 pubmed publisher
    ..The overexpression of NPIPB3 restored the IFN-β responses in SARS-CoV ORF6 expressing cells, indicating that the interaction of SARS CoV ORF6 and NPIPB3 reduced Type I IFN antagonism by SARS-CoV ORF6. ..
  33. Schürmann R, Bald I. Effect of adsorption kinetics on dissociation of DNA-nucleobases on gold nanoparticles under pulsed laser illumination. Phys Chem Chem Phys. 2017;19:10796-10803 pubmed publisher
    ..For adenine and its brominated analog, the decomposition products are further analyzed by surface enhanced Raman scattering (SERS) indicating a strong fragmentation of the molecules into their smallest subunits.
  34. Jahn I, Žukovskaja O, Zheng X, Weber K, Bocklitz T, Cialla May D, et al. Surface-enhanced Raman spectroscopy and microfluidic platforms: challenges, solutions and potential applications. Analyst. 2017;142:1022-1047 pubmed publisher
    ..in the last four years on the development and application of systems based on surface-enhanced Raman spectroscopy (SERS) combined with microfluidic devices demonstrates that this research field is a current hot topic...
  35. Lin Z, Yang J, Tang Z, Li G, Hu Y. Nitrogen dots as reductant and stabilizer for the synthesis of AgNPs/N-dots nanocomposites for efficient surface-enhanced Raman scattering detection. Talanta. 2018;178:515-521 pubmed publisher
    ..Furthermore, the synthesized AgNPs/N-dots showed high surface-enhanced Raman scattering (SERS) activity and provided a sensitive SERS sensing ability for malachite green (MG) and crystal violet (CV) in ..
  36. Kumar P, Kim K, Vellingiri K, Samaddar P, Kumar P, Deep A, et al. Hybrid porous thin films: Opportunities and challenges for sensing applications. Biosens Bioelectron. 2018;104:120-137 pubmed publisher
    ..g., surface-enhanced Raman scattering (SERS))...
  37. Wang L, Wu J. Characterizing the dynamics underlying global spread of epidemics. Nat Commun. 2018;9:218 pubmed publisher
    ..Our framework not only elucidates the dynamics underlying global spread of epidemics but also advances our capability in nowcasting and forecasting epidemics. ..
  38. Li J, Wang W, Tang S, Song W, Xuan L. Jatrophanes as promising multidrug resistance modulators: Advances of structure-activity relationships. Fitoterapia. 2018;127:138-145 pubmed publisher
    ..The SARs are discussed, which reveal that introduction of an alkyl acyl group bearing 4 carbons at C-14 or an aryl acyl group with electron donating groups is favorable for the activity. ..
  39. Nogala W, Kannan P, Gawinkowski S, Jönsson Niedziolka M, Kominiak M, Waluk J, et al. Tailored gold nanostructure arrays as catalysts for oxygen reduction in alkaline media and a single molecule SERS platform. Nanoscale. 2015;7:10767-74 pubmed publisher
    ..Electrocatalytic oxygen reduction in alkaline media and surface-enhanced Raman spectroscopy (SERS) of single porphycene molecules are presented as model examples.
  40. Wang Y, Wee E, Trau M. Highly sensitive DNA methylation analysis at CpG resolution by surface-enhanced Raman scattering via ligase chain reaction. Chem Commun (Camb). 2015;51:10953-6 pubmed publisher
    ..and accurate DNA methylation analysis at CpG resolution was demonstrated using surface-enhanced Raman scattering (SERS) via ligase chain reaction (LCR)...
  41. Kitahama Y, Egashira M, Suzuki T, Tanabe I, Ozaki Y. Reply to the comment on "Sensitive marker bands for the detection of spin states of heme in surface-enhanced resonance Raman scattering spectra of metmyoglobin". Analyst. 2015;140:6147-8 pubmed publisher
    In our SERRS spectra of metmyoglobin by excitation at 514 nm, the peak at 1510 cm(-1), which is assigned to the 6-coordinated heme in the low spin state, was observed by the addition of imidazole and NaN3...
  42. Zhou H, Wang Q, Yuan D, Wang J, Huang Y, Wu H, et al. Early apoptosis real-time detection by label-free SERS based on externalized phosphatidylserine. Analyst. 2016;141:4293-8 pubmed publisher
    ..Herein, we report a new SERS sensing strategy for in vitro sensitive detection of early apoptotic cells...
  43. Lei J, Hilgenfeld R. Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin. Virol Sin. 2016;31:288-99 pubmed publisher
    ..The structure and the mutational study help understand common and unique features of the deubiquitinating activity of MERS-CoV PL(pro). ..
  44. He L, Wang Y, Xie X, Han M, Song F, Wang B, et al. Correction: Systematic investigation of the SERS efficiency and SERS hotspots in gas-phase deposited Ag nanoparticle assemblies. Phys Chem Chem Phys. 2017;19:17469 pubmed publisher
    Correction for 'Systematic investigation of the SERS efficiency and SERS hotspots in gas-phase deposited Ag nanoparticle assemblies' by L. B. He et al., Phys. Chem. Chem. Phys., 2017, 19, 5091-5101.
  45. Maxwell C, McGeer A, Tai K, Sermer M. No. 225-Management Guidelines for Obstetric Patients and Neonates Born to Mothers With Suspected or Probable Severe Acute Respiratory Syndrome (SARS). J Obstet Gynaecol Can. 2017;39:e130-e137 pubmed publisher
    ..Case reports were reviewed and expert opinion sought. Recommendations were made according to the guidelines developed by the Canadian Task Force on Preventive Health Care. The Society of Obstetricians and Gynaecologists of Canada. ..
  46. Wang F, Chen C, Liu X, Yang K, Xu X, Yang H. Crystal Structure of Feline Infectious Peritonitis Virus Main Protease in Complex with Synergetic Dual Inhibitors. J Virol. 2016;90:1910-7 pubmed publisher
    ..Our study provides new insight into the pharmaceutical strategy against CoV M(pro) through using zinc as an adjuvant therapy to enhance the efficacy of an irreversible peptidomimetic inhibitor. ..
  47. Ye S, Zhai X, Wu Y, Kuang S. Dual-primer self-generation SERS signal amplification assay for PDGF-BB using label-free aptamer. Biosens Bioelectron. 2016;79:130-5 pubmed publisher
    ..In this work, a simple and novel one-two-three signal amplification surface-enhanced Raman scattering (SERS) method for the detection of protein is fabricated by using label-free aptamer and dual-primer self-generation...
  48. Yang J, Chen W, Kang D, Lu X, Li X, Liu Z, et al. Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives targeting the entrance channel of NNRTI binding pocket. Eur J Med Chem. 2016;109:294-304 pubmed publisher
    ..Preliminary structure-activity relationships (SARs) and molecular modeling of the new diarylpyridine derivatives were discussed in detail. ..
  49. Crnkovic A, Čavužić M, Godinic Mikulcic V, Anderluh G, Weygand Đurašević I, Gruic Sovulj I. An archaeal aminoacyl-tRNA synthetase complex for improved substrate quality control. Biochimie. 2018;147:36-45 pubmed publisher
    ..In the archaeon Methanothermobacter thermautotrophicus arginyl- and seryl-tRNA synthetase (ArgRS and SerRS, respectively) form a complex which enhances serylation and facilitates tRNASer recycling through its ..
  50. Gao S, Pearson B, He L. Mapping bacteria on filter membranes, an innovative SERS approach. J Microbiol Methods. 2018;147:69-75 pubmed publisher
    ..In this study, we applied surface enhanced Raman spectroscopy (SERS) to rapidly screen bacteria cells on a filter membrane based on the unique signal from an indicator molecule, 4-..
  51. Lin L, Gu H, Ye J. Plasmonic multi-shell nanomatryoshka particles as highly tunable SERS tags with built-in reporters. Chem Commun (Camb). 2015;51:17740-3 pubmed publisher
    Here we report on the synthesis and averaged SERS measurements of multi-shell nanomatryoshka SERS tags...
  52. Hidi I, Heidler J, Weber K, Cialla May D, Popp J. Ciprofloxacin: pH-dependent SERS signal and its detection in spiked river water using LoC-SERS. Anal Bioanal Chem. 2016;408:8393-8401 pubmed
    ..Among the newly developed analytical methods, the lab-on-a-chip surface-enhanced Raman spectroscopic (LoC-SERS) technique has gained the interest of the scientific community in the last few years...
  53. Lee S, Chang S, Lai Y, Lin C, Tsai C, Lee Y, et al. Effect of Temperature on the Growth of Silver Nanoparticles Using Plasmon-Mediated Method under the Irradiation of Green LEDs. Materials (Basel). 2014;7:7781-7798 pubmed publisher
    ..Measuring the surface-enhanced Raman spectroscopy (SERS) spectra of the probe molecule R6G in the presence of KBr showed that both silver nanoplate colloids synthesized at ..
  54. Kayastha S, Kunimoto R, Horvath D, Varnek A, Bajorath J. From bird's eye views to molecular communities: two-layered visualization of structure-activity relationships in large compound data sets. J Comput Aided Mol Des. 2017;31:961-977 pubmed publisher
    ..Analysis of CSNs makes it possible to distinguish between regions having different SAR characteristics and select compound subsets that are rich in SAR information. ..
  55. Lee J, Hwang A, Choi H, Jo Y, Kim B, Kang T, et al. A Multivalent Structure-Specific RNA Binder with Extremely Stable Target Binding but Reduced Interaction to Nonspecific RNAs. Angew Chem Int Ed Engl. 2017;: pubmed publisher
    ..The optimized 24-meric PAZ showed nearly irreversible binding to target RNA with negligible binding to nonspecific RNA, and this ultra-specific 24-meric PAZ probe allowed SERS detection of intact microRNAs at an attomolar level.
  56. Marshall A, Stokes J, Viscomi F, Proctor J, Gierschner J, Bouillard J, et al. Determining molecular orientation via single molecule SERS in a plasmonic nano-gap. Nanoscale. 2017;9:17415-17421 pubmed publisher
    ..coupled to an extended silver film have been fully optimized for single molecule Surface-Enhanced Raman Scattering (SERS) spectroscopy...
  57. Gühlke M, Heiner Z, Kneipp J. Combined near-infrared excited SEHRS and SERS spectra of pH sensors using silver nanostructures. Phys Chem Chem Phys. 2015;17:26093-100 pubmed publisher
    Surface-enhanced hyper-Raman scattering (SEHRS) and surface-enhanced Raman scattering (SERS) of para-mercaptobenzoic acid (pMBA) were studied with an excitation wavelength of 1064 nm, using different silver nanostructures as substrates ..
  58. Jubb A, Jiao Y, Eres G, Retterer S, Gu B. Elevated gold ellipse nanoantenna dimers as sensitive and tunable surface enhanced Raman spectroscopy substrates. Nanoscale. 2016;8:5641-8 pubmed publisher
    ..with precisely controlled gaps for use as sensitive and highly controllable surface enhanced Raman scattering (SERS) substrates...
  59. Mostowtt T, McCord B. Surface enhanced Raman spectroscopy (SERS) as a method for the toxicological analysis of synthetic cannabinoids. Talanta. 2017;164:396-402 pubmed publisher
    ..A potential solution to this problem is surface enhanced Raman spectroscopy (SERS). In this study we demonstrate the analysis of a set of structurally similar synthetic cannabinoids using SERS...
  60. Cao J, Zhao D, Mao Q. A highly reproducible and sensitive fiber SERS probe fabricated by direct synthesis of closely packed AgNPs on the silanized fiber taper. Analyst. 2017;142:596-602 pubmed publisher
    A surface-enhanced Raman scattering (SERS) tapered fiber probe has been developed by using a chemically-etched tapered fiber tip and silanization of the surface of the fiber taper, followed by the hydrothermal growth of silver ..
  61. Zhang W, Cai Y, Qian R, Zhao B, Zhu P. Synthesis of Ball-Like Ag Nanorod Aggregates for Surface-Enhanced Raman Scattering and Catalytic Reduction. Nanomaterials (Basel). 2016;6: pubmed publisher
    ..These Ag nanorod aggregates exhibit effective SERS effect, evaluated by Rhodamine 6G (R6G) and doxorubicin (DOX) as probe molecules...
  62. Oliveira M, Quaresma P, Peixoto de Almeida M, Araújo A, Pereira E, Fortunato E, et al. Office paper decorated with silver nanostars - an alternative cost effective platform for trace analyte detection by SERS. Sci Rep. 2017;7:2480 pubmed publisher
    For analytical applications in portable sensors to be used in the point-of-need, low-cost SERS substrates using paper as a base, are an alternative...
  63. de Wilde A, Snijder E, Kikkert M, van Hemert M. Host Factors in Coronavirus Replication. Curr Top Microbiol Immunol. 2017;: pubmed publisher
  64. Shi Q, Huang J, Sun Y, Yin M, Hu M, Hu X, et al. Utilization of a lateral flow colloidal gold immunoassay strip based on surface-enhanced Raman spectroscopy for ultrasensitive detection of antibiotics in milk. Spectrochim Acta A Mol Biomol Spectrosc. 2018;197:107-113 pubmed publisher
    ..lateral flow immunoassay (LFI) strip, in combination with high sensitivity surface-enhanced Raman spectroscopy (SERS)...
  65. Stevenson R, Hueber A, Hutton A, McInnes I, Graham D. Nanoparticles and inflammation. ScientificWorldJournal. 2011;11:1300-12 pubmed publisher
    ..with magnetic resonance imaging (MRI), fluorescent quantum dots (QDs), and surface enhanced Raman scattering (SERS) probes being just some of the new methodologies employed...
  66. Hu Y, Zhao T, Zhu P, Zhu Y, Liang X, Sun R, et al. Tailoring Size and Coverage Density of Silver Nanoparticles on Monodispersed Polymer Spheres as Highly Sensitive SERS Substrates. Chem Asian J. 2016;11:2428-35 pubmed publisher
    ..The surface enhanced Raman scattering (SERS) performances of the resulting uniform CPS/Ag hybrid particles were investigated using 4-aminobenzenethiol (4-ABT) ..
  67. Wang M, Xu S, Wu C, Liu X, Tao H, Huang Y, et al. Design, synthesis and activity of novel sorafenib analogues bearing chalcone unit. Bioorg Med Chem Lett. 2016;26:5450-5454 pubmed publisher
  68. Nayak T, Andreou C, Oseledchyk A, Marcus W, Wong H, Massague J, et al. Tissue factor-specific ultra-bright SERRS nanostars for Raman detection of pulmonary micrometastases. Nanoscale. 2017;9:1110-1119 pubmed publisher
    Here we demonstrate a novel application of 'surface enhanced resonance Raman scattering nanoparticles' (SERRS NPs) for imaging breast cancer lung metastases with much higher precision than currently feasible...
  69. John A, Tomas M, Hari A, Wilson B, Donskey C. Do medical students receive training in correct use of personal protective equipment?. Med Educ Online. 2017;22:1264125 pubmed publisher
  70. Famiglini V, Castellano S, Silvestri R. N-Pyrrylarylsulfones with High Therapeutic Potential. Molecules. 2017;22: pubmed publisher
    ..The literature reviewed here may provide useful information on the potential of N-pyrrylarylsulfone pharmacophore as well as suggest concepts for the design and synthesis of new N-pyrrylarylsulfone based agents. ..
  71. Han X, Koh C, Lee H, Chew W, Ling X. Microchemical Plant in a Liquid Droplet: Plasmonic Liquid Marble for Sequential Reactions and Attomole Detection of Toxin at Microliter Scale. ACS Appl Mater Interfaces. 2017;9:39635-39640 pubmed publisher
    ..These molecular events are tracked in situ via SERS measurement through the plasmonic shell and further verified with in silico investigation...
  72. Fikiet M, Khandasammy S, Mistek E, Ahmed Y, Halámková L, Bueno J, et al. Surface enhanced Raman spectroscopy: A review of recent applications in forensic science. Spectrochim Acta A Mol Biomol Spectrosc. 2018;197:255-260 pubmed publisher
    ..A variety of new SERS surfaces and novel approaches are presented here on a wide range of forensically relevant topics.
  73. Han S, Zhou G, Fu Y, Ma Y, Xu L, Zou C, et al. The alloying effect and AgCl-directing growth for synthesizing a trimetallic nanoring with improved SERS. Nanoscale. 2015;7:20414-25 pubmed publisher
    ..The formed Pt/Ag layer changes the etching direction from along [100] to [111] and generates the TAAPN. Besides, it has been noted that the TAAPNs exhibit good Surface Enhanced Raman Scattering (SERS) performance.
  74. Wang J, Duan G, Liu G, Li Y, Chen Z, Xu L, et al. Detection of dimethyl methylphosphonate by thin water film confined surface-enhanced Raman scattering method. J Hazard Mater. 2016;303:94-100 pubmed publisher
    ..However, based on the surface-enhanced Raman scattering (SERS) effect, detection of nerve agent simulant dimethyl methylphosphonate (DMMP) which is weakly interacted with SERS-..
  75. Smith C, de Jong C, Meers J, Henning J, Wang L, Field H. Coronavirus Infection and Diversity in Bats in the Australasian Region. Ecohealth. 2016;13:72-82 pubmed publisher
    ..Thus, our findings are consistent with a scenario wherein the current diversity and host specificity of coronaviruses reflects co-evolution with the occasional host shift. ..
  76. Phan Quang G, Lee H, Ling X. Isolating Reactions at the Picoliter Scale: Parallel Control of Reaction Kinetics at the Liquid-Liquid Interface. Angew Chem Int Ed Engl. 2016;55:8304-8 pubmed publisher
    ..Using the surface-enhanced Raman spectroscopy (SERS) technique, in?situ monitoring of the interfacial protonation of dimethyl yellow (p-dimethylaminoazobenzene (DY)) ..
  77. Wu J, Li X, Wan W, Yang Q, Ma W, Chen D, et al. Gigantol from Dendrobium chrysotoxum Lindl. binds and inhibits aldose reductase gene to exert its anti-cataract activity: An in vitro mechanistic study. J Ethnopharmacol. 2017;198:255-261 pubmed publisher
    ..was evaluated by UV-visible spectroscopy, atomic force microscope (AFM) and surface-enhanced Raman spectroscopy (SERS). The binding constant was determined by UV-visible. Gigantol depressed AR gene expression in HLECs...
  78. Wang M, Zhang K, Gu Q, Bi X, Wang J. Pharmacology of mangostins and their derivatives: A comprehensive review. Chin J Nat Med. 2017;15:81-93 pubmed publisher
    ..Meanwhile, the pharmacokinetics (PK) profile and recent toxicological studies of mangostins are also described for further druggability exploration in the future. ..
  79. Yang C, Xie F, Jiang Y, Li Z, Huang X, Li L. Phytochrome A Negatively Regulates the Shade Avoidance Response by Increasing Auxin/Indole Acidic Acid Protein Stability. Dev Cell. 2018;44:29-41.e4 pubmed publisher
    ..Specifically, PHYA competes with TIR1 by directly binding and stabilizing AUX/IAA. Our findings illustrate a mechanistic model of how plants sense different shade levels to fine-tune auxin signaling and generate appropriate SAR. ..
  80. Hassan S, Ejaz S, Saeed A, Shehzad M, Ullah Khan S, Lecka J, et al. 4-Aminopyridine based amide derivatives as dual inhibitors of tissue non-specific alkaline phosphatase and ecto-5'-nucleotidase with potential anticancer activity. Bioorg Chem. 2018;76:237-248 pubmed publisher
    ..Molecular docking studies were also carried out to gain insight into the binding interaction of potent compounds within the respective enzyme pockets and herring-sperm DNA. ..
  81. Kodera S, Gomez Tames J, Hirata A. Temperature elevation in the human brain and skin with thermoregulation during exposure to RF energy. Biomed Eng Online. 2018;17:1 pubmed publisher
    ..The effect of vasodilation is significant, especially at higher frequencies where skin temperature elevation is dominant. ..
  82. Tran M, Whale A, Padalkar S. Exploring the Efficacy of Platinum and Palladium Nanostructures for Organic Molecule Detection via Raman Spectroscopy. Sensors (Basel). 2018;18: pubmed publisher
    ..However, they have been considered non-active for surface enhanced Raman spectroscopy (SERS). In this work, we explore the scattering contributions of Pd and Pt for the detection of organic molecules...
  83. Huang B, Wang X, Liu X, Chen Z, Li W, Sun S, et al. Discovery of novel DAPY-IAS hybrid derivatives as potential HIV-1 inhibitors using molecular hybridization based on crystallographic overlays. Bioorg Med Chem. 2017;25:4397-4406 pubmed publisher
    ..Preliminary structure-activity relationships (SARs), structure-cytotoxicity relationships, molecular modeling studies, and in silico calculation of physicochemical properties of these new inhibitors were also discussed. ..
  84. Zhu W, Wu Y, Yan C, Wang C, Zhang M, Wu Z. Facile Synthesis of Mono-Dispersed Polystyrene (PS)/Ag Composite Microspheres via Modified Chemical Reduction. Materials (Basel). 2013;6:5625-5638 pubmed publisher
    ..FESEM), energy-dispersive X-ray spectroscopy (EDS), XRD, UV-Vis and surface-enhanced Raman spectroscopy (SERS)...
  85. Hassoun M, Rüger J, Kirchberger Tolstik T, Schie I, Henkel T, Weber K, et al. A droplet-based microfluidic chip as a platform for leukemia cell lysate identification using surface-enhanced Raman scattering. Anal Bioanal Chem. 2018;410:999-1006 pubmed publisher
    A new approach is presented for cell lysate identification which uses SERS-active silver nanoparticles and a droplet-based microfluidic chip...
  86. Jamshidi Z, Khodabandeh M, Mohammadpour M, Visscher L. Reply to the 'Comment on "Elucidation of charge-transfer SERS selection rules by considering the excited state properties and the role of electrode potential"' by M. Mohammadpour, M. H. Khodabandeh, L. Visscher and Z. Jamshidi, Phys. Chem. Chem. Phys. Phys Chem Chem Phys. 2017;19:27892-27894 pubmed publisher
    We appreciate Aranda's comments on our recent work entitled ''Elucidation of charge-transfer SERS selection rules by considering the excited state properties and the role of electrode potential''...
  87. Yasuda S, Yoshii T, Chiashi S, Maruyama S, Murakoshi K. Plasmon-Induced Selective Oxidation Reaction at Single-Walled Carbon Nanotubes. ACS Appl Mater Interfaces. 2017;9:38992-38998 pubmed publisher
    ..single-walled nanotubes (SWNTs) on the nanometer scale was investigated using surface-enhanced Raman scattering (SERS) measurements...
  88. Guicheteau J, Tripathi A, Emmons E, Christesen S, Fountain A. Reassessing SERS enhancement factors: using thermodynamics to drive substrate design. Faraday Discuss. 2017;: pubmed publisher
    Over the past 40 years fundamental and application research into Surface-Enhanced Raman Scattering (SERS) has been explored by academia, industry, and government laboratories...
  89. Fortuni B, Inose T, Uezono S, Toyouchi S, Umemoto K, Sekine S, et al. In situ synthesis of Au-shelled Ag nanoparticles on PDMS for flexible, long-life, and broad spectrum-sensitive SERS substrates. Chem Commun (Camb). 2017;53:11298-11301 pubmed publisher
    ..on a polydimethylsiloxane (PDMS) film and their improvement as highly sensitive surface enhanced Raman scattering (SERS) substrates via atomically thin Au coatings is demonstrated...
  90. Chatterjee A, Gale D, Grebennikov D, Whelan L, Merschrod S E. Surface potential and morphology mapping to investigate analyte adsorption effects on surface enhanced Raman scattering (SERS). Chem Commun (Camb). 2017;53:12024-12027 pubmed publisher
    ..microscopy (KPFM) in enabling a comprehensive study of enhancement mechanisms of surface enhanced Raman scattering (SERS) through the correlation of surface electrical and topographical effects...
  91. Offeddu V, Yung C, Low M, Tam C. Effectiveness of Masks and Respirators Against Respiratory Infections in Healthcare Workers: A Systematic Review and Meta-Analysis. Clin Infect Dis. 2017;65:1934-1942 pubmed publisher
    ..Multicentre RCTs with standardized protocols conducted outside epidemic periods would help to clarify the circumstances under which the use of masks or respirators is most warranted...
  92. Bhamidipati M, Fabris L. Multiparametric Assessment of Gold Nanoparticle Cytotoxicity in Cancerous and Healthy Cells: The Role of Size, Shape, and Surface Chemistry. Bioconjug Chem. 2017;28:449-460 pubmed publisher
    In recent years, we and others have become interested in evaluating the use of surface-enhanced Raman scattering (SERS) tags for early cancer detection and in designing new approaches to demonstrate the applicability of this spectroscopic ..