SERPINF2

Summary

Gene Symbol: SERPINF2
Description: serpin family F member 2
Alias: A2AP, AAP, ALPHA-2-PI, API, PLI, alpha-2-antiplasmin, alpha-2-AP, alpha-2-plasmin inhibitor, serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2, serpin F2, serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
Species: human
Products:     SERPINF2

Top Publications

  1. Sazonova I, Thomas B, Gladysheva I, Houng A, Reed G. Fibrinolysis is amplified by converting alpha-antiplasmin from a plasmin inhibitor to a substrate. J Thromb Haemost. 2007;5:2087-94 pubmed
    ..In summary, these mAbs appear to act at sites distinct from known alpha(2)-AP-plasmin contacts to enhance fibrinolysis by converting alpha(2)-AP from an inhibitor to a plasmin substrate. ..
  2. O Seaghdha C, Yang Q, Glazer N, Leak T, Dehghan A, Smith A, et al. Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. Hum Mol Genet. 2010;19:4296-303 pubmed publisher
    ..We conclude that common genetic variation in the CASR gene is associated with similar but milder features in the general population. ..
  3. Franceschini N, van Rooij F, Prins B, Feitosa M, Karakas M, Eckfeldt J, et al. Discovery and fine mapping of serum protein loci through transethnic meta-analysis. Am J Hum Genet. 2012;91:744-53 pubmed publisher
    ..identified six loci at genome-wide significance (p < 5 × 10(-8)) for serum albumin (HPN-SCN1B, GCKR-FNDC4, SERPINF2-WDR81, TNFRSF11A-ZCCHC2, FRMD5-WDR76, and RPS11-FCGRT, in up to 53,190 European-ancestry and 9,380 Japanese ..
  4. Samlaska C, Winfield E. Pentoxifylline. J Am Acad Dermatol. 1994;30:603-21 pubmed
    ..Fibroblast responsiveness to tumor necrosis factor is also diminished. Potential medical uses of pentoxifylline are reviewed. ..
  5. Cavalcante M, Torres Romero J, Lobo M, Moreno F, Bezerra L, Lima D, et al. A panel of glycoproteins as candidate biomarkers for early diagnosis and treatment evaluation of B-cell acute lymphoblastic leukemia. Biomark Res. 2016;4:1 pubmed publisher
    ..Clusterin (CLU), thrombin (F2), heparin cofactor II (SERPIND1), alpha-2-macroglobulin (A2M), alpha-2-antiplasmin (SERPINF2), Alpha-1 antitrypsin (SERPINA1), Complement factor B (CFB) and Complement C3 (C3) were identified as candidate ..
  6. Nguyen T, Alibrahim E, Islam F, Klein R, Klein B, Cotch M, et al. Inflammatory, hemostatic, and other novel biomarkers for diabetic retinopathy: the multi-ethnic study of atherosclerosis. Diabetes Care. 2009;32:1704-9 pubmed publisher
    ..These data suggest that there is limited clinical use of these biomarkers for prediction of diabetic retinopathy. ..
  7. Sculco P, McLawhorn A, Desai N, Su E, Padgett D, Jules Elysee K. The Effect of Perioperative Corticosteroids in Total Hip Arthroplasty: A Prospective Double-Blind Placebo Controlled Pilot Study. J Arthroplasty. 2016;31:1208-1212 pubmed publisher
    ..The study group had improved postoperative analgesia and a trend toward improved functional outcome at 3 months postoperatively. ..
  8. Baker S, Chen Z, Norris E, Revenko A, MacLeod A, Strickland S. Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2018;115:E9687-E9696 pubmed publisher
    ..and decreased glial cell activation in the brain, whereas an increase in PL activity through α-2-antiplasmin (A2AP) antisense oligonucleotide treatment exacerbated the brain's immune response and plaque deposition...
  9. Maheshwari N, Kantipudi S, Maheshwari A, Arora K, Vandana -, Kwatra N, et al. Amino-Terminal Fusion of Epidermal Growth Factor 4,5,6 Domains of Human Thrombomodulin on Streptokinase Confers Anti-Reocclusion Characteristics along with Plasmin-Mediated Clot Specificity. PLoS ONE. 2016;11:e0150315 pubmed publisher
    ..The EGF-SK construct exhibited fibrin clot dissolution properties with much-lowered levels of fibrinogenolysis, suggesting unmistakable promise in clot dissolver therapy with reduced hemorrhage and re-occlusion risks. ..

More Information

Publications151 found, 100 shown here

  1. Peetermans M, Vanassche T, Liesenborghs L, Claes J, Vande Velde G, Kwiecinksi J, et al. Plasminogen activation by staphylokinase enhances local spreading of S. aureus in skin infections. BMC Microbiol. 2014;14:310 pubmed publisher
    ..SAK contributes to the phenotype of S. aureus skin infections by enhancing bacterial spreading as a result of fibrinolytic and proteolytic activation. ..
  2. Eddy J, Schroeder J, Zimbler D, Bellows L, Lathem W. Impact of the Pla protease substrate α2-antiplasmin on the progression of primary pneumonic plague. Infect Immun. 2015;83:4837-47 pubmed publisher
    ..and cleave multiple proteins within the fibrinolytic pathway, including the plasmin inhibitor α2-antiplasmin (A2AP). It is not known, however, if Pla inactivates A2AP in vivo; the role of A2AP during respiratory Y...
  3. McLawhorn A, Beathe J, YaDeau J, Buschiazzo V, Purdue P, Ma Y, et al. Effects of steroids on thrombogenic markers in patients undergoing unilateral total knee arthroplasty: a prospective, double-blind, randomized controlled trial. J Orthop Res. 2015;33:412-6 pubmed publisher
    ..1087 ± 536 µg/L), but did not reach statistical significance (p = 0.07). These results may have clinical implications in terms of postoperative VTE risk and management. ..
  4. Nielsen V, Boyer L, Matika R, Amos Q, Redford D. Iron and carbon monoxide attenuate Crotalus atrox venom-enhanced tissue-type plasminogen activator-initiated fibrinolysis. Blood Coagul Fibrinolysis. 2016;27:511-6 pubmed publisher
    ..Future preclinical investigation is required to determine if iron and CO can attenuate venom-mediated degradation of alpha-2-antiplasmin-dependent fibrinolytic resistance. ..
  5. Perez J, Sakata M, Colucci J, Spinelli G, Felipe C, Carvalho V, et al. Plasma proteomics for the assessment of acute renal transplant rejection. Life Sci. 2016;158:111-20 pubmed publisher
    ..and that were strongly associated with each other: they are alpha-1 antitrypsin (A1AT), alpha-2 antiplasmin (A2AP), serum amyloid A (SAA) and apolipoprotein CIII (APOC3)...
  6. Prabhudesai A, Shetty S, Ghosh K, Kulkarni B. Dysfunctional fibrinolysis and cerebral venous thrombosis. Blood Cells Mol Dis. 2017;65:51-55 pubmed publisher
    ..Along with conventional thrombophilia, dysfunctional fibrinolysis is found to be strongly associated with CVT. Understanding the role of risk factors is important for appropriate treatment of this serious disorder. ..
  7. Bolliger D, Szlam F, Levy J, Molinaro R, Tanaka K. Haemodilution-induced profibrinolytic state is mitigated by fresh-frozen plasma: implications for early haemostatic intervention in massive haemorrhage. Br J Anaesth. 2010;104:318-25 pubmed publisher
    ..Therefore, early fluid replacement therapy with FFP might be advantageous after massive haemorrhage. ..
  8. Uitte de Willige S, Malfliet J, Abdul S, Leebeek F, Rijken D. The level of circulating fibroblast activation protein correlates with incorporation of alpha-2-antiplasmin into the fibrin clot. Thromb Res. 2018;166:19-21 pubmed publisher
  9. Cooper J, Ozcan S, Gardner R, Rustogi N, Wicks S, van Rees G, et al. Schizophrenia-risk and urban birth are associated with proteomic changes in neonatal dried blood spots. Transl Psychiatry. 2017;7:1290 pubmed publisher
  10. Jellinger P, Handelsman Y, Rosenblit P, Bloomgarden Z, Fonseca V, Garber A, et al. AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF DYSLIPIDEMIA AND PREVENTION OF CARDIOVASCULAR DISEASE. Endocr Pract. 2017;23:1-87 pubmed publisher
    ..Simvastatin Survival Study A1C = glycated hemoglobin AACE = American Association of Clinical Endocrinologists AAP = American Academy of Pediatrics ACC = American College of Cardiology ACE = American College of Endocrinology ACS = ..
  11. Parkan Õ, Atalay M, Koc A, Pala C, Aydemir G, Kaynar L. [Fungemia and septic arthritis caused by Saprochaete capitata in a patient with fanconi aplastic anemia: a case report]. Mikrobiyol Bul. 2017;51:87-93 pubmed
    ..Urease test was negative, and according to API 20C AUX (bioMérieux, France) system, none of the carbonhydrates were utilized except glucose...
  12. Wzorek J, Karpiński M, Wypasek E, Michalski M, Szczudlik A, Malinowski K, et al. Alpha-2-antiplasmin Arg407Lys polymorphism and cryptogenic ischemic cerebrovascular events: Association with neurological deficit. Neurol Neurochir Pol. 2018;52:352-358 pubmed publisher
    ..Our findings suggest that the α2AP Arg407Lys polymorphism could be involved in the pathogenesis of cerebral ischemia and its outcomes. ..
  13. Sivapalaratnam S, Collins J, Gomez K. Diagnosis of inherited bleeding disorders in the genomic era. Br J Haematol. 2017;179:363-376 pubmed publisher
    ..Here, we discuss the different diagnostic tools currently available for inherited bleeding disorders and suggest that genotyping should be incorporated at an early stage in the diagnostic pathway. ..
  14. Beris F, Budak E, Gülek D, Uzun A, Cizmeci Z, Mengeloğlu F, et al. [Investigation of the frequency and distribution of beta-lactamase genes in the clinical isolates of Acinetobacter baumannii collected from different regions of Turkey: a multicenter study]. Mikrobiyol Bul. 2016;50:511-521 pubmed
    ..isolates were performed by both conventional methods and automated systems, VITEK2 Compact (BioMerieux, France) and API 32GN (BioMerieux, France)...
  15. Çelikbilek N, Gözalan A, Özdem B, Kırca F, Açıkgöz Z. [Extended-spectrum beta-lactamase production by Enterobacteriaceae isolates from urine cultures of outpatients: results of a 7-year follow-up]. Mikrobiyol Bul. 2015;49:259-65 pubmed
    ..Enterobacteriaceae strains were isolated and identified by conventional methods and API 20E system (BioMérieux, France)...
  16. Xia B, Zhu Q, Zhao Y, Ge W, Zhao Y, Song Q, et al. Phthalate exposure and childhood overweight and obesity: Urinary metabolomic evidence. Environ Int. 2018;121:159-168 pubmed publisher
    ..Urinary concentrations of six phthalate monoesters (MMP, MEP, MnBP, MEHP, MEOHP and MEHHP) were measured using API 2000 electrospray triple quadrupole mass spectrometer (ESIMS/MS)...
  17. Gayretli Aydin Z, Tanir G, Nar Ötgün S, Turan M, Aydın Teke T, Kaman A, et al. [Screening of Corynebacterium diphtheriae, Corynebacterium ulcerans and Corynebacterium pseudotuberculosis in throat swab specimens of children with upper respiratory tract infections]. Mikrobiyol Bul. 2017;51:209-219 pubmed publisher
    ..suspected colonies with positive cystinase activity were identified by conventional methods and also with Coryne API (Biomerieux, France) systems. Toxicity tests (ELEK, PCR) were performed to investigate whether the C...
  18. Bouzouraa T, René Martellet M, Chene J, Attipa C, Lebert I, Chalvet Monfray K, et al. Clinical and laboratory features of canine Anaplasma platys infection in 32 naturally infected dogs in the Mediterranean basin. Ticks Tick Borne Dis. 2016;7:1256-1264 pubmed publisher
    Since the first description of Anaplasma platys Infection (ApI), the disease has been sporadically reported worldwide...
  19. Seliem W, Sultan A. Etiology of early onset neonatal sepsis in neonatal intensive care unit - Mansoura, Egypt. J Neonatal Perinatal Med. 2018;11:323-330 pubmed publisher
    ..Identification of Gram-negative isolates was confirmed by API 20E kits (bioMerieux). Antibiotic susceptibility was performed by Kirby-Bauer disc diffusion method...
  20. Demir F, KuÅŸtimur S. [Investigation of some virulence factors in Trichosporon spp. strains]. Mikrobiyol Bul. 2014;48:628-38 pubmed
    ..arthrospores, pseudohyphae and true hyphae) on corn meal agar media, and carbohydrate assimilation patterns (API ID32C; bioMérieux, France)...
  21. Ou W, Cui L, Li Y, Zheng B, Lv Y. Epidemiological characteristics of blaNDM-1 in Enterobacteriaceae and the Acinetobacter calcoaceticus-Acinetobacter baumannii complex in China from 2011 to 2012. PLoS ONE. 2014;9:e113852 pubmed publisher
    ..For blaNDM-1-positive strains, 16S rRNA analysis and Analytical Profile Index (API) strips were used to identify the bacterial genus and species...
  22. Hanaka A, Nowak A, Plak A, Dresler S, Ozimek E, Jaroszuk Sciseł J, et al. Bacterial Isolate Inhabiting Spitsbergen Soil Modifies the Physiological Response of Phaseolus coccineus in Control Conditions and under Exogenous Application of Methyl Jasmonate and Copper Excess. Int J Mol Sci. 2019;20: pubmed publisher
    ..originating from Spitsbergen soil, and identified as Pseudomonas luteola using the analytical profile index (API) test. Above- and under-ground plant parts were analyzed...
  23. Sarges P, Steinberg J, Lewis J. Drug-Induced Liver Injury: Highlights from a Review of the 2015 Literature. Drug Saf. 2016;39:801-21 pubmed publisher
    ..the necessary predictive value to determine the prognosis and outcome of patients with paracetamol (acetaminophen [AAP])-induced acute liver failure (ALF), and may be of great benefit in deciding who requires N-acetylcysteine (NAC), ..
  24. Abamecha A, Wondafrash B, Abdissa A. Antimicrobial resistance profile of Enterococcus species isolated from intestinal tracts of hospitalized patients in Jimma, Ethiopia. BMC Res Notes. 2015;8:213 pubmed publisher
    ..5% NaCl broth, growth at 45°C, motility test and by using API 20 Streptococcus system. Sensitivity testing was done using Kirby-Bauer disk diffusion method...
  25. Fioranelli A, Carpentieri E, Wolosker N, Castelli V, Caffaro R. Rupture of Thrombosed Popliteal Aneurysm: A Case Report. Ann Vasc Surg. 2018;51:324.e7-324.e10 pubmed publisher
    Asymptomatic rupture of a popliteal arterial aneurysm (AAP) is rare but has been previously reported in the literature. Here, we present the first case of a thrombosed AAP that ruptured and developed into an abscess...
  26. Dai X, Shi X, Gao X, Liang J, Zhang X. Salipiger nanhaiensis sp. nov., a bacterium isolated from deep sea water. Int J Syst Evol Microbiol. 2015;65:1122-6 pubmed publisher
    ..D-arabitol and L-arabitol after inoculating for 24 h and weakly positive results were also detected after 48 h in API 50CH strips with D-arabinose, L-arabinose, L-xylose, adonitol, mannose, aesculin, salicin, sucrose, mycose and L-..
  27. Wu Z, Ding G, Huang F, Yang Z, Yu F, Tang Y, et al. Anticancer Activity of Anthopleura anjunae Oligopeptides in Prostate Cancer DU-145 Cells. Mar Drugs. 2018;16: pubmed publisher
    i>Anthopleura anjunae anti-tumor peptide (AAP-H) is a pentapeptide from the sea anemone Anthopleura anjunae with an amino acid sequence of Tyr-Val-Pro-Gly-Pro that is obtained by alkaline protease enzymatic hydrolysis ..
  28. Patil Y, Junghare M, Pester M, Müller N, Schink B. Anaerobium acetethylicum gen. nov., sp. nov., a strictly anaerobic, gluconate-fermenting bacterium isolated from a methanogenic bioreactor. Int J Syst Evol Microbiol. 2015;65:3289-96 pubmed publisher
    ..5-8.5, with optimal growth at pH 7, and the generation time under optimal conditions was 60 min. API Rapid 32A reactions were positive for α-galactosidase, α-glucosidase and β-glucosidase and negative for ..
  29. Takahashi T, Yamanishi T, Nobukawa S, Kasakawa S, Yoshimura Y, Hiraishi H, et al. Band-specific atypical functional connectivity pattern in childhood autism spectrum disorder. Clin Neurophysiol. 2017;128:1457-1465 pubmed publisher
    ..Magnetoencephalographic signals were quantified using graph-theoretic metrics with a phase lag index (PLI) for specific bands in 24 children with autism spectrum disorder and 24 typically developing controls...
  30. Hirosawa S, Nakamura Y, Miura O, Sumi Y, Aoki N. Organization of the human alpha 2-plasmin inhibitor gene. Proc Natl Acad Sci U S A. 1988;85:6836-40 pubmed
  31. Omar W, Saleh Y, Marie M. The use of biotic and abiotic components of Red Sea coastal areas as indicators of ecosystem health. Ecotoxicology. 2016;25:253-66 pubmed publisher
    ..assessment was carried out using contamination factor (CF), geoaccumulation index (Igeo), pollution load index (PLI) and enrichment factor (EF)...
  32. Song Y, Shin E, Wang H, Nolan J, Low S, PARSONS D, et al. A novel in situ hydrophobic ion paring (HIP) formulation strategy for clinical product selection of a nanoparticle drug delivery system. J Control Release. 2016;229:106-119 pubmed publisher
    ..release rates without altering the chemical structures of the polymer or active pharmaceutical ingredient (API). This was accomplished through the use of a hydrophobic ion pairing approach...
  33. Badruddoza A, Godfrin P, Myerson A, Trout B, Doyle P. Core-Shell Composite Hydrogels for Controlled Nanocrystal Formation and Release of Hydrophobic Active Pharmaceutical Ingredients. Adv Healthc Mater. 2016;5:1960-8 pubmed publisher
    ..Organic phase nanoemulsion droplets stabilized by polyvinyl alcohol (PVA) and containing a model hydrophobic API (fenofibrate) are embedded in the alginate hydrogel matrix and subsequently act as crystallization reactors...
  34. Wang B, Meng L. Functional brain network alterations in epilepsy: A magnetoencephalography study. Epilepsy Res. 2016;126:62-9 pubmed publisher
    ..with epilepsy and twenty healthy controls, constructed the whole functional brain network based on phase lag index (PLI), compared the differences in functional connectivity and network measures between patients with epilepsy and ..
  35. Pawar J, Narkhede R, Amin P, Tawde V. Design and Evaluation of Topical Diclofenac Sodium Gel Using Hot Melt Extrusion Technology as a Continuous Manufacturing Process with Kolliphor® P407. AAPS PharmSciTech. 2017;18:2303-2315 pubmed publisher
    ..The DSC and XRD analysis of the HME gel formulation showed complete melting of crystalline API into an amorphous form...
  36. Smitha Ninan A, Shah A, Song J, Jameson P. Differential Gene Expression in the Meristem and during Early Fruit Growth of Pisum sativum L. Identifies Potential Targets for Breeding. Int J Mol Sci. 2017;18: pubmed publisher
    ..expression was shown between genes and within gene families for IPT, CKX, SUT, and AAP. PsCKX7 showed strong gene family member-specific expression in the SAM, and was also expressed in young pea ..
  37. Ruggenthaler M, Grass J, Schuh W, Huber C, Reischl R. Impurity profiling of liothyronine sodium by means of reversed phase HPLC, high resolution mass spectrometry, on-line H/D exchange and UV/Vis absorption. J Pharm Biomed Anal. 2017;143:147-158 pubmed publisher
    For the first time, a comprehensive investigation of the impurity profile of the synthetic thyroid API (active pharmaceutical ingredient) liothyronine sodium (LT3Na) was performed by using reversed phase HPLC and advanced ..
  38. Piekarz T, Mertas A, Wiatrak K, Rój R, Kownacki P, Smieszek Wilczewska J, et al. The Influence of Toothpaste Containing Australian Melaleuca alternifolia Oil and Ethanolic Extract of Polish Propolis on Oral Hygiene and Microbiome in Patients Requiring Conservative Procedures. Molecules. 2017;22: pubmed publisher
    ..Approximal plaque index (API), simplified oral hygiene index (OHI-s) and modified sulcus bleeding index (mSBI) were assessed in three subsequent ..
  39. Koblížek M. Ecology of aerobic anoxygenic phototrophs in aquatic environments. FEMS Microbiol Rev. 2015;39:854-70 pubmed publisher
    ..Aside from cyanobacteria and proteorhodopsin-containing bacteria, aerobic anoxygenic phototrophic (AAP) bacteria are the third most numerous group of phototrophic prokaryotes in the ocean...
  40. Ackerman I, Jordan J, Van Doornum S, Ricardo M, Briggs A. Understanding the information needs of women with rheumatoid arthritis concerning pregnancy, post-natal care and early parenting: A mixed-methods study. BMC Musculoskelet Disord. 2015;16:194 pubmed publisher
    ..Tool (ENAT, range 0-156, higher scores indicate higher educational needs) and the Autonomy Preference Index (API, range 0-100, higher scores indicate stronger preferences)...
  41. Cheng Z, Oguejiofor C, Swangchan Uthai T, Carr S, Wathes D. Relationships between Circulating Urea Concentrations and Endometrial Function in Postpartum Dairy Cows. Animals (Basel). 2015;5:748-73 pubmed publisher
    ..g., BRINP1, FOXG1), immune function (e.g., IL17RB, CRISPLD2), inflammation (e.g., C3, SERPINF1, SERPINF2) and lipid metabolism (e.g., SCAP, ACBD5, SLC10A)...
  42. Kochev N, Paskaleva V, Jeliazkova N. Ambit-Tautomer: An Open Source Tool for Tautomer Generation. Mol Inform. 2013;32:481-504 pubmed publisher
    ..Ambit-Tautomer module is available for download as a Java library, a command line application, a demo web page or OpenTox API compatible Web service.
  43. Song G, Banov D, Bassani A, Valdez B. Evaluation of the Safety, Cell Migration, and Mucoadhesive Properties of a Mucoadhesive Polymer Blend in Human Oral Mucosa. AAPS PharmSciTech. 2017;18:1617-1623 pubmed publisher
    The efficacy of active pharmaceutical ingredients (API) in compounded medications for oral mucosa greatly depends on the composition of the base...
  44. Shoaib M, Ansari A, Ahn S. cMapper: gene-centric connectivity mapper for EBI-RDF platform. Bioinformatics. 2017;33:266-271 pubmed publisher
    ..We developed the user interface using HTML5, JQuery and the Cytoscape Graph API. cMapper can be accessed at http://cmapper.ewostech...
  45. Alshahri F. Heavy metal contamination in sand and sediments near to disposal site of reject brine from desalination plant, Arabian Gulf: Assessment of environmental pollution. Environ Sci Pollut Res Int. 2017;24:1821-1831 pubmed publisher
    ..The contamination factor (CF), modified degree of contamination (mCd) and pollution load index (PLI) were assessed...
  46. Pattamapun K, Handagoon S, Sastraruji T, Gutmann J, Pavasant P, Krisanaprakornkit S. Decreased levels of matrix metalloproteinase-2 in root-canal exudates during root canal treatment. Arch Oral Biol. 2017;82:27-32 pubmed publisher
    ..treatment for prosthodontic reasons and from twelve teeth with pulp necrosis and asymptomatic apical periodontitis (AAP) were sampled with paper points for bacterial culture and aspirated for the detection of proMMP-2 and active MMP-2 ..
  47. Thompson C, Broecker J, Dade M, Nottingham K. Influences on Intentions to Place Long-Acting Reversible Contraceptives: A Pilot Study Comparing According to Provider Specialty in Ohio. J Pediatr Adolesc Gynecol. 2018;31:509-515 pubmed publisher
    ..For pediatricians who do not feel comfortable providing device placement themselves, other strategies should be encouraged to facilitate provision of LARCs. ..
  48. Saha N, Rahman M, Jolly Y, Rahman A, Sattar M, Hai M. Spatial distribution and contamination assessment of six heavy metals in soils and their transfer into mature tobacco plants in Kushtia District, Bangladesh. Environ Sci Pollut Res Int. 2016;23:3414-26 pubmed publisher
    ..five areas in Kushtia District were suggested as uncontaminated according to both C d and pollution load index (PLI)...
  49. Chao S, Wakeel F, Nazinyan Y, Sun S. Does Preconception Health Differ by Nativity?: Findings from the Los Angeles Mommy and Baby (LAMB) Study. Matern Child Health J. 2016;20:769-77 pubmed publisher
    ..regardless of race/ethnicity, and to determine if any identified differences vary among Asian/Pacific Islanders (API's) and Hispanics. Data are from the 2012 Los Angeles Mommy and Baby study (n = 6252)...
  50. Hammad S, Knösel M. Efficacy of a new sealant to prevent white spot lesions during fixed orthodontic treatment : A 12-month, single-center, randomized controlled clinical trial. J Orofac Orthop. 2016;77:439-445 pubmed
    ..Oral hygiene was assessed using the Approximal Plaque Index (API) at specified time intervals...
  51. Rauta P, Ashe S, Nayak D, Nayak B. In silico identification of outer membrane protein (Omp) and subunit vaccine design against pathogenic Vibrio cholerae. Comput Biol Chem. 2016;65:61-68 pubmed publisher
    ..having B-cell binding sites were selected from sequence alignment after B cell epitopes prediction by BCPred and AAP prediction modules of BCPreds...
  52. Cern A, Marcus D, Tropsha A, Barenholz Y, Goldblum A. New drug candidates for liposomal delivery identified by computer modeling of liposomes' remote loading and leakage. J Control Release. 2017;252:18-27 pubmed publisher
    ..is in most cases the best method for achieving high concentrations of active pharmaceutical ingredients (API) per nano-liposome that enable therapeutically viable API-loaded nano-liposomes, referred to as nano-drugs...
  53. You J, Yang Y, Liu L, Hu C. [Prior periodontal intervention lowers incidence of lower respiratory infection in patients receiving oral and maxillofacial tumor surgery]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37:1256-1260 pubmed
    ..The PLI, BOP, PPD, and CAL were significantly lower and GR was higher in the intervention group than in the control group (..
  54. Li B, Ding X, Evivie S, Jin D, Meng Y, Huo G, et al. Short communication: Genomic and phenotypic analyses of exopolysaccharides produced by Streptococcus thermophilus KLDS SM. J Dairy Sci. 2018;101:106-112 pubmed publisher
    ..able to ferment sucrose, mannose, glucose, galactose, and lactose from the genomic research, which was confirmed by API 50 CH (bioMérieux, Marcy l'Etoile, France)...
  55. Szeleszczuk Ł, Jurczak E, Zielińska Pisklak M, Harwacki J, Pisklak D. Comparison of the analytical methods (solid state NMR, FT-IR, PXRD) in the analysis of the solid drug forms with low concentration of an active ingredient - 17-?-estradiol case. J Pharm Biomed Anal. 2018;149:160-165 pubmed publisher
    ..of various techniques (FT-IR, PXRD, ssNMR) in the analysis of solid dosage forms with low concentration of an API (17-?-estradiol hemihydrate, EBHH) was tested...
  56. Khalil E, Abd Manap M, Mustafa S, Alhelli A, Shokryazdan P. Probiotic Properties of Exopolysaccharide-Producing Lactobacillus Strains Isolated from Tempoyak. Molecules. 2018;23: pubmed publisher
    ..fermentum, L. crispatus, L. reuteri, and L. pentosus-which were identified using API 50 CHL and 16S rRNA gene sequences (Polymerase chain reaction, PCR - based)...
  57. Reiter J, Breuer A, Breuer O, Hashavya S, Rekhtman D, Kerem E, et al. A quality improvement intervention to reduce emergency department radiography for bronchiolitis. Respir Med. 2018;137:1-5 pubmed publisher
    ..77%, p = 0.05). This key intervention was successful in reinforcing the AAP guidelines, promoting greater cost-effectiveness, reducing radiation exposure, and saving valuable time and ..
  58. Daouk S, Chèvre N, Vernaz N, Widmer C, Daali Y, Fleury Souverain S. Dynamics of active pharmaceutical ingredients loads in a Swiss university hospital wastewaters and prediction of the related environmental risk for the aquatic ecosystems. Sci Total Environ. 2016;547:244-253 pubmed publisher
    The wastewater contamination of a Swiss university hospital by active pharmaceutical ingredient (API) residues was evaluated with a three months monitoring campaign at the outlet of the main building...
  59. Frank K, Boeck G. Development of a nanosuspension for iv administration: From miniscale screening to a freeze dried formulation. Eur J Pharm Sci. 2016;87:112-7 pubmed publisher
    ..Freeze drying was evaluated for one formulation containing 2% of the API, 0.5% of arginine and 4% of mannitol...
  60. Juusola J, Quisel T, Foschini L, Ladapo J. The Impact of an Online Crowdsourcing Diagnostic Tool on Health Care Utilization: A Case Study Using a Novel Approach to Retrospective Claims Analysis. J Med Internet Res. 2016;18:e127 pubmed publisher
    ..to access their medical claims data, which was retrieved through a third-party web application program interface (API)...
  61. Zheng J, Cheng Z, Jia H, Zheng Y. Characterization of aspartyl aminopeptidase from Toxoplasma gondii. Sci Rep. 2016;6:34448 pubmed publisher
    ..Finally, the activity of drug CID 23724194, previously described as targeting Plasmodium and malarial parasite AAP, was tested against rTgAAP and the parasite. Overall, TgAAP knockout affected the growth of T...
  62. Negrin L, Halat G, Prosch H, Hüpfl M, Hajdu S, Heinz T. Soluble Receptor for Advanced Glycation End Products Quantifies Lung Injury in Polytraumatized Patients. Ann Thorac Surg. 2017;103:1587-1593 pubmed publisher
    ..trauma might leak into the vascular compartment and therefore reflect the severity of parenchymal lung injury (PLI). Five promising proteins were preselected after a literature scan...
  63. Dalpiaz A, Pavan B, Ferretti V. Can pharmaceutical co-crystals provide an opportunity to modify the biological properties of drugs?. Drug Discov Today. 2017;22:1134-1138 pubmed publisher
    ..Pharmaceutical co-crystals, formed by an active pharmaceutical substance (API) and a co-crystal former, can show enhanced dissolution and permeation values compared with those of the parent ..
  64. Schaeffer P, Asnes A. What Do Pediatricians Tell Parents About Bed-Sharing?. Matern Child Health J. 2018;22:51-58 pubmed publisher
    ..infants and whether pediatricians provide specific recommendations outlined by the American Academy of Pediatrics (AAP)...
  65. Zuo W, Guo C, Liu J, Peng X, Yang M. A Police and Insurance Joint Management System Based on High Precision BDS/GPS Positioning. Sensors (Basel). 2018;18: pubmed publisher
    ..Thus the third-party application developers can call the general location Application Programming Interface (API) of the original standard Global Navigation Satellite System (GNSS) to get high precision positioning results...
  66. Sreenivasulu J, Venkata Ramana P, Sampath Kumar Reddy G, Rakesh M, Nagaraju C, Thirumalai Rajan S, et al. Development of Novel RP-HPLC Method for Separation and Estimation of Critical Geometric Isomer and Other Related Impurities of Tafluprost Drug Substance and Identification of Major Degradation Compounds by Using LC-MS. J Chromatogr Sci. 2016;54:1397-407 pubmed publisher
    ..determination of the geometric isomer (Trans) and other related substances in the active pharmaceutical ingredient (API) of Tafluprost (TFL), with their determination by an assay...
  67. Ko K, Kwon M, Yang S, Moon C, Lee E, Woo H, et al. Evaluation of Serum Cotinine Cut-Off to Distinguish Smokers From Nonsmokers in the Korean Population. Ann Lab Med. 2016;36:427-33 pubmed publisher
    ..USA) and LC-MS/MS (API-4000, Applied Biosystems, USA)...
  68. Sorkin D, Murphy M, Nguyen H, Biegler K. Barriers to Mental Health Care for an Ethnically and Racially Diverse Sample of Older Adults. J Am Geriatr Soc. 2016;64:2138-2143 pubmed publisher
    ..The total sample consisted of 75,324 non-Hispanic white (NHW), 6,600 black, 7,695 Asian and Pacific Islander (API), and 4,319 Hispanic adults aged 55 and older...
  69. Wang Z, Zhao Q, Li L, Hu P, Dong K, Chen S, et al. Development and validation of a rapid and sensitive UPLC-MS/MS method for quantification of kukoamine B in human plasma: Application to a clinical pharmacokinetic study. J Pharm Biomed Anal. 2017;132:1-6 pubmed publisher
    ..standard (5-deuterated isotope kukoamine B) were detected under the multiple-reaction monitoring mode by an API 5500 triple quadrupole mass spectrometer with electrospray ionization. The method showed good linearity from 0...
  70. Khan Z, Ahmad K, Rehman S, Siddique S, Bashir H, Zafar A, et al. Health risk assessment of heavy metals in wheat using different water qualities: implication for human health. Environ Sci Pollut Res Int. 2017;24:947-955 pubmed publisher
    ..Moreover, the pollution load index (PLI), accumulation factor (AF), daily intake of metals (DIM), and health risk index (HRI) were calculated...
  71. Kreth M, Shikany T, Lenker C, Troxler R. Safe Sleep Guideline Adherence in Nationwide Marketing of Infant Cribs and Products. Pediatrics. 2017;139: pubmed publisher
    ..often promote infant sleep environments that are counter to the most recent American Academy of Pediatrics (AAP) guidelines...
  72. Igbinosa I, Beshiru A, Odjadjare E, Ateba C, Igbinosa E. Pathogenic potentials of Aeromonas species isolated from aquaculture and abattoir environments. Microb Pathog. 2017;107:185-192 pubmed publisher
    ..Aeromonas species were isolated on Glutamate Starch Phenol Red (GSP) agar and confirmed using API 20NE kits...
  73. Zhong Y, Jin C, Gan J, Wang X, Shi Z, Xia X, et al. Apigenin attenuates patulin-induced apoptosis in HEK293 cells by modulating ROS-mediated mitochondrial dysfunction and caspase signal pathway. Toxicon. 2017;137:106-113 pubmed publisher
    ..This study aimed to evaluate the protective effect of apigenin (API), one of the most bioactive flavonoids in plant-derived food, on PAT-induced apoptosis in HEK293 cells...
  74. Konate A, Barro Kiki P, Kassi K, Angora K, Vanga Bosson H, Djohan V, et al. Oropharyngeal candidiasis prevalence among HIV-infected patients at the teaching hospital of Treichville (Abidjan, Côte d'Ivoire). J Mycol Med. 2017;27:549-553 pubmed publisher
    ..were cultured, and Candida species were identified using a germ tube test, a chlamydospore formation assay, and the API 20C system. A total of 286 patients were included, among whom 99.1% were infected with HIV...
  75. Kiesel B, Scemama J, Parise R, Villaruz L, Iffland A, Doyle A, et al. LC-MS/MS assay for the quantitation of the ATR kinase inhibitor VX-970 in human plasma. J Pharm Biomed Anal. 2017;146:244-250 pubmed publisher
    ..1% formic acid from a 50μL sample volume. Detection was achieved using an API 4000 mass spectrometer using electrospray positive ionization mode...
  76. Zhou Y, Li L, Hu L. Correlation Analysis of PM10 and the Incidence of Lung Cancer in Nanchang, China. Int J Environ Res Public Health. 2017;14: pubmed publisher
    ..SOâ‚‚, NOâ‚‚, PM10, annual haze days, and annual mean Air Pollution Index/Air Quality Index (API/AQI). Air pollution has a greater impact on urban inhabitants as compared to rural inhabitants...
  77. Xie Y, Yao Y. Octenylsuccinate hydroxypropyl phytoglycogen, a dendrimer-like biopolymer, solubilizes poorly water-soluble active pharmaceutical ingredients. Carbohydr Polym. 2018;180:29-37 pubmed publisher
    ..docetaxel, fenofibrate, griseofulvin, and resveratrol) was incorporated with OHPP to form solid dispersions (API-OHPP SD). API-OHPP SD reduced API crystallinity and increased API solubility by up to 1755 times...
  78. Lehmkemper K, Kyeremateng S, Bartels M, Degenhardt M, Sadowski G. Physical stability of API/polymer-blend amorphous solid dispersions. Eur J Pharm Biopharm. 2018;124:147-157 pubmed publisher
    ..In this work, the physical stability of API/polymer-blend ASDs was investigated by thermodynamic modeling and stability studies...
  79. Edinger M, Bar Shalom D, Rantanen J, Genina N. Visualization and Non-Destructive Quantification of Inkjet-Printed Pharmaceuticals on Different Substrates Using Raman Spectroscopy and Raman Chemical Imaging. Pharm Res. 2017;34:1023-1036 pubmed publisher
    ..Haloperidol was used as a model active pharmaceutical ingredient (API), and a printable ink base containing lactic acid and ethanol was developed...
  80. Rydzewska L, Burdett S, Vale C, Clarke N, Fizazi K, Kheoh T, et al. Adding abiraterone to androgen deprivation therapy in men with metastatic hormone-sensitive prostate cancer: A systematic review and meta-analysis. Eur J Cancer. 2017;84:88-101 pubmed publisher
    ..This systematic review aims to assess the effects of adding abiraterone acetate plus prednisone/prednisolone (AAP) to ADT...
  81. Wang Y, Yang Q, Dong J, Huang H. Competitive adsorption of PPCP and humic substances by carbon nanotube membranes: Effects of coagulation and PPCP properties. Sci Total Environ. 2018;619-620:352-359 pubmed publisher
    ..In this study, four types of PPCP, as such acetaminophen (AAP), caffeine (CAF), triclosan (TCS), and carbendazim (CBD) were used to investigate the effects of PPCP properties ..
  82. Zida A, Issiaka S, Sanata B, Samuel S, Ibrahim S, Marcel S, et al. 25S rDNA genotype and antifungal susceptibility of clinical Candida albicans in Ouagadougou (Burkina Faso). Med Mycol. 2017;: pubmed publisher
    ..They were diagnosed as C. albicans using germ tube test, chlamydospore formation, and Api-Candida test. Genotyping was performed using PCR targeting 25S rDNA...
  83. Liu Y, Wu J, Yu D, Ma Q. The relationship between urban form and air pollution depends on seasonality and city size. Environ Sci Pollut Res Int. 2018;25:15554-15567 pubmed publisher
    ..5, API, and exceedance) in 83 Chinese cities, with explicit consideration of city size and seasonality...
  84. Shibata N, Kawarai T, Meng Y, Lee J, Lee H, Wakutani Y, et al. Association studies between the plasmin genes and late-onset Alzheimer's disease. Neurobiol Aging. 2007;28:1041-3 pubmed
    ..In a North European case-control AD dataset we studied 14 common variations in the PLG, PAI-1, PLAT and PLI genes encoding components of the plasmin system...
  85. Lee K, Jackson K, Christiansen V, Dolence E, McKee P. Enhancement of fibrinolysis by inhibiting enzymatic cleavage of precursor ?2-antiplasmin. J Thromb Haemost. 2011;9:987-96 pubmed publisher
    ..These data establish that inhibition of APCE might represent a therapeutic approach for enhancing thrombolytic activity. ..
  86. Mousavi F, Majd A, Shahali Y, Ghahremaninejad F, Shokouhi Shoormasti R, Pourpak Z. Immunoproteomics of tree of heaven (Ailanthus atltissima) pollen allergens. J Proteomics. 2017;154:94-101 pubmed publisher
    Ailanthus altissima pollen (AAP) is considered as an emerging cause of respiratory allergy in United States, Italy and Iran. However, the allergenic composition of AAP is still unknown and has yet to be characterized...
  87. Xiong S, Luo Y, Zhong L, Xiao H, Pan H, Liao K, et al. Investigation of the inhibitory potential of phospholipase A2 inhibitor gamma from Sinonatrix annularis to snake envenomation. Toxicon. 2017;137:83-91 pubmed publisher
    SaPLIγ is a novel gamma phospholipase A2 inhibitor (PLI) recently isolated from Sinonatrix annularis, a Chinese endemic non-venomous snake...
  88. Iliou K, Malenović A, Loukas Y, Dotsikas Y. Analysis of potential genotoxic impurities in rabeprazole active pharmaceutical ingredient via Liquid Chromatography-tandem Mass Spectrometry, following quality-by-design principles for method development. J Pharm Biomed Anal. 2018;149:410-418 pubmed publisher
    ..determination of two potential genotoxic impurities (PGIs) in rabeprazole active pharmaceutical ingredient (API)...
  89. Zhao Y, Tsang C, Xiao M, Chan J, Lau S, Kong F, et al. Yeast identification by sequencing, biochemical kits, MALDI-TOF MS and rep-PCR DNA fingerprinting. Med Mycol. 2017;: pubmed publisher
    ..Using sequencing results as the standard, 78.9% and 71.8% isolates were correctly identified using the API 20C AUX and Vitek 2 YST ID Card systems, respectively; and 90.1% and 80...
  90. Christiansen V, Jackson K, Lee K, McKee P. The effect of a single nucleotide polymorphism on human alpha 2-antiplasmin activity. Blood. 2007;109:5286-92 pubmed
    ..Therefore, the Arg6Trp polymorphism may play a significant role in governing the long-term deposition/removal of intravascular fibrin. ..
  91. Zhang Y, Kagen A. Machine Learning Interface for Medical Image Analysis. J Digit Imaging. 2017;30:615-621 pubmed publisher
    ..Our goal is to extend the TensorFlow API to accept raw DICOM images as input; 1513 DaTscan DICOM images were obtained from the Parkinson's Progression ..
  92. Haidar Ahmad I, Tam J, Li X, Duffield W, Tarara T, Blasko A. Cleaning verification: Exploring the effect of the cleanliness of stainless steel surface on sample recovery. J Pharm Biomed Anal. 2017;134:108-115 pubmed publisher
    ..cleaning verification method development have been studied, including active pharmaceutical ingredient (API) level, spiking procedure, API/excipient ratio, analyst-to-analyst variability, inter-day variability, and cleaning ..