SERPINE2

Summary

Gene Symbol: SERPINE2
Description: serpin family E member 2
Alias: GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI, glia-derived nexin, glial-derived neurite promoting factor, peptidase inhibitor 7, protease nexin I, serpin E2, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Species: human
Products:     SERPINE2

Top Publications

  1. Farrell D, Wagner S, Yuan R, Cunningham D. Localization of protease nexin-1 on the fibroblast extracellular matrix. J Cell Physiol. 1988;134:179-88 pubmed
    ..These data indicate that in addition to its role as a soluble protease inhibitor, PN-1 is also a component of the extracellular matrix and might control its proteolysis. ..
  2. Carter R, Cerosaletti K, Burkin D, Fournier R, Jones C, Greenberg B, et al. The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes. Genomics. 1995;27:196-9 pubmed
    b>Protease nexin I (PNI) is the most important physiologic regulator of alpha-thrombin in tissues...
  3. DeMeo D, Campbell E, Barker A, Brantly M, Eden E, McElvaney N, et al. IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency. Am J Respir Cell Mol Biol. 2008;38:114-20 pubmed
    ..for 10 genes previously associated with asthma and/or COPD, including IL10, TNF, GSTP1, NOS1, NOS3, SERPINA3, SERPINE2, SFTPB, TGFB1, and EPHX1. All analyses were performed in a cohort of 378 PI ZZ individuals from 167 families...
  4. Castaldi P, Hersh C, Reilly J, Silverman E. Genetic associations with hypoxemia and pulmonary arterial pressure in COPD. Chest. 2009;135:737-744 pubmed publisher
    ..SNPs) were genotyped in five candidate genes previously associated with COPD susceptibility (EPHX1, SERPINE2, SFTPB, TGFB1, and GSTP1)...
  5. Lee R, Fan C, Hwu Y, Lu C, Lin M, Chen Y, et al. SERPINE2, an inhibitor of plasminogen activators, is highly expressed in the human endometrium during the secretory phase. Reprod Biol Endocrinol. 2011;9:38 pubmed publisher
    b>SERPINE2, also known as protease nexin-1, belongs to the serine protease inhibitor (SERPIN) superfamily. It is one of the potent SERPINs that modulates the activity of plasminogen activators (PAs)...
  6. Chern S, Li S, Chiu C, Chang H, Chen C, Tsuen Chen E. Spatiotemporal expression of SERPINE2 in the human placenta and its role in extravillous trophoblast migration and invasion. Reprod Biol Endocrinol. 2011;9:106 pubmed publisher
    b>SERPINE2, one of the potent serpins belonging to the plasminogen activator (PA) system, is involved in the tissue remodeling...
  7. Gloor S, Odink K, Guenther J, Nick H, Monard D. A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins. Cell. 1986;47:687-93 pubmed
    A glia-derived neurite promoting factor (GdNPF) has serine protease inhibitory activity and in addition regulates the migration of neuronal cells...
  8. Scott R, Bergman B, Bajpai A, Hersh R, Rodriguez H, Jones B, et al. Protease nexin. Properties and a modified purification procedure. J Biol Chem. 1985;260:7029-34 pubmed
    ..The present characterization pertains to the fraction of protease nexin having the higher affinity for heparin. The low affinity material, which is the minor fraction, is lost during purification. ..
  9. Li X, Herz J, Monard D. Activation of ERK signaling upon alternative protease nexin-1 internalization mediated by syndecan-1. J Cell Biochem. 2006;99:936-51 pubmed
    ..Most important, in contrast to PKA activation known to be triggered by LRP1-mediated internalization, our study shows that syndecan-1-mediated internalization of PN-1 stimulated the Ras-ERK signaling pathway. ..

More Information

Publications110 found, 100 shown here

  1. DeMeo D, Mariani T, Lange C, Lake S, Litonjua A, CELEDON J, et al. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006;3:502 pubmed
  2. Bouton M, Venisse L, Richard B, Pouzet C, Arocas V, Jandrot Perrus M. Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect. Circ Res. 2007;100:1174-81 pubmed
    ..Furthermore, PN-1 decreased the cofactor activity of TM on thrombin activable fibrinolysis inhibitor activation by thrombin. These data show for the first time that PN-1 forms complexes with TM and modulates its anticoagulant activity. ..
  3. Zhu G, Warren L, Aponte J, Gulsvik A, Bakke P, Anderson W, et al. The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations. Am J Respir Crit Care Med. 2007;176:167-73 pubmed
    ..A positional candidate gene from the chromosome 2q region SERPINE2 (Serpin peptidase inhibitor, clade E [nexin, plasminogen activator inhibitor type 1], member 2), was previously ..
  4. Foreman M, DeMeo D, Hersh C, Carey V, Fan V, Reilly J, et al. Polymorphic variation in surfactant protein B is associated with COPD exacerbations. Eur Respir J. 2008;32:938-44 pubmed publisher
    ..beta-1 (TGFB1), serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 (SERPINE2), glutathione S-transferase pi (GSTP1) and surfactant protein B (SFTPB) were genotyped in 389 non-Hispanic white ..
  5. Kim W, Hersh C, DeMeo D, Reilly J, Silverman E. Genetic association analysis of COPD candidate genes with bronchodilator responsiveness. Respir Med. 2009;103:552-7 pubmed publisher
    ..was completed for 122 single nucleotide polymorphisms (SNPs) in six candidate genes (EPHX1, SFTPB, TGFB1, SERPINE2, GSTP1, ADRB2)...
  6. Zhong L, Fu W, Sun C, Dai L, Zhang Y. Absence of association between SERPINE2 genetic polymorphisms and chronic obstructive pulmonary disease in Han Chinese: a case-control cohort study. BMC Med Genet. 2009;10:66 pubmed publisher
    Recent studies have proposed that the serine protease inhibitor E2 (SERPINE2) was a novel susceptibility gene for chronic obstructive pulmonary disease (COPD) in Caucasians. However, this issue still remained controversial...
  7. Nagahara A, Nakayama M, Oka D, Tsuchiya M, Kawashima A, Mukai M, et al. SERPINE2 is a possible candidate promotor for lymph node metastasis in testicular cancer. Biochem Biophys Res Commun. 2010;391:1641-6 pubmed publisher
    ..microarray analysis showed that JKT-HM cells highly expressed the Serpine peptidase inhibitor, clade E, member 2 (SERPINE2), which encodes a secreted protein...
  8. Kim W, Hoffman E, Reilly J, Hersh C, DeMeo D, Washko G, et al. Association of COPD candidate genes with computed tomography emphysema and airway phenotypes in severe COPD. Eur Respir J. 2011;37:39-43 pubmed publisher
    ..Three SNPs in EPHX1, five SNPs in SERPINE2 and one SNP in GSTP1 were significantly associated with LAA950...
  9. Fujimoto K, Ikeda S, Arai T, Tanaka N, Kumasaka T, Ishii T, et al. Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases. BMC Med Genet. 2010;11:159 pubmed publisher
    The SERPINA1, SERPINA3, and SERPINE2 genes, which encode antiproteases, have been proposed to be susceptible genes for of chronic obstructive pulmonary disease (COPD) and related phenotypes...
  10. DeMeo D, Mariani T, Lange C, Srisuma S, Litonjua A, Celedon J, et al. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet. 2006;78:253-64 pubmed
    ..studies with human COPD linkage results on chromosome 2q to prioritize candidate-gene selection, thus identifying SERPINE2 as a positional candidate susceptibility gene for COPD...
  11. Fayard B, Bianchi F, Dey J, Moreno E, Djaffer S, Hynes N, et al. The serine protease inhibitor protease nexin-1 controls mammary cancer metastasis through LRP-1-mediated MMP-9 expression. Cancer Res. 2009;69:5690-8 pubmed publisher
    ..These results suggest that PN-1 might become a prognostic marker in breast cancer. ..
  12. Cha S, Kang H, Choi J, Kim M, Park J, Lee W, et al. SERPINE2 polymorphisms and chronic obstructive pulmonary disease. J Korean Med Sci. 2009;24:1119-25 pubmed publisher
    ..It was hypothesized that the SERPINE2 gene, which is one of the genes located at the 2q33.3-2q37...
  13. Shestakova K, Brito A, Mesonzhnik N, Moskaleva N, Kurynina K, Grestskaya N, et al. Rabbit plasma metabolomic analysis of Nitroproston®: a multi target natural prostaglandin based-drug. Metabolomics. 2018;14:112 pubmed publisher
    ..PGE2, 13,14-dihydro-15-keto-PGE2, PGB2, 1,3-GDN and 15-keto-PGE2 increased in the treatment group. Steroids (i.e...
  14. Carvalho J, Lisboa P, de Oliveira E, Peixoto Silva N, Nobre J, Fraga M, et al. Effects of postnatal bromocriptine injection on thyroid function and prolactinemia of rats at adulthood. Neuropeptides. 2016;59:71-81 pubmed publisher
    ..The respective controls were injected with methanol-saline. Offspring were killed at adulthood (PN180). Adult PN1-10 BRO-treated animals had lower food intake, hypoprolactinemia, lower leptin action (lower OBR-b, STAT-3 and SOCS-..
  15. Cossa A, Lima D, do Vale T, de Alencar Rocha A, da Graça Naffah Mazzacoratti M, da Silva Fernandes M, et al. Maternal seizures can affect the brain developing of offspring. Metab Brain Dis. 2016;31:891-900 pubmed publisher
    ..14)C-leucine [(14)C-Leu] incorporation was used to analyze protein synthesis at PN1, and Western Blot method was used to analyze protein levels of Bax, Bcl-2 and Poly(ADP-ribose) polymerase-1 (PARP-1)..
  16. Wrobel M, Sundararaghavan H. Biomaterial Cues to Direct a Pro-regenerative Phenotype in Macrophages and Schwann Cells. Neuroscience. 2018;376:172-187 pubmed publisher
    Following peripheral nerve injury (PNI), inflammatory cues impede repair...
  17. Ustün R, Oğuz E, Seker A, Korkaya H. Thymoquinone protects DRG neurons from axotomy-induced cell death. Neurol Res. 2018;40:930-937 pubmed publisher
    Peripheral nerve injury (PNI) is a significant health problem that is linked to sensory, motor, and autonomic deficits. This pathological condition leads to a reduced quality of life in most affected individuals...
  18. Longo R, Melgar E, Campitiello M, Plastino F, Eid N, Quirin I, et al. Breast metastasis from squamous cell carcinoma of the oropharynx: a case report. J Med Case Rep. 2017;11:355 pubmed publisher
    ..Two years before, she had undergone radical resection of a squamous cell carcinoma of the oropharynx (stage pT2, pN1), which was followed by adjuvant radiotherapy...
  19. Panizza B, Solares C, Redmond M, Parmar P, O Rourke P. Surgical resection for clinical perineural invasion from cutaneous squamous cell carcinoma of the head and neck. Head Neck. 2012;34:1622-7 pubmed publisher
    Perineural invasion (PNI) in cutaneous squamous cell carcinoma of the head and neck (SCCHN) is associated with decreased survival...
  20. Sternberg C, Skoneczna I, Kerst J, Albers P, Fossa S, Agerbaek M, et al. Immediate versus deferred chemotherapy after radical cystectomy in patients with pT3-pT4 or N+ M0 urothelial carcinoma of the bladder (EORTC 30994): an intergroup, open-label, randomised phase 3 trial. Lancet Oncol. 2015;16:76-86 pubmed publisher
    ..Eligible patients had histologically proven urothelial carcinoma of the bladder, pT3-pT4 disease or node positive (pN1-3) M0 disease after radical cystectomy and bilateral lymphadenectomy, with no evidence of any microscopic residual ..
  21. Feng Z, Xu Q, Qin L, Li H, Han Z. Predicting Radiotherapy Necessity in Tongue Cancer Using Lymph Node Yield. J Oral Maxillofac Surg. 2017;75:1062-1070 pubmed publisher
    In patients with head and neck cancer and a single metastatic lymph node (pN1), the value of lymph node yield (LNY) remains controversial in determining the prognosis and identifying patients who require radiotherapy...
  22. Chen Y, Lin C, Li C, Huang S, Chan J, Fang W, et al. Associations among integrated psychoneuroimmunological factors and metabolic syndrome. Psychoneuroendocrinology. 2016;74:342-349 pubmed publisher
    Metabolic syndrome (MetS) has been reported to cause considerable psychoneuroimmunology (PNI) disturbances such as, psychological distress, autonomic nervous imbalance, and impaired immune function...
  23. Bornelöv S, Seroussi E, Yosefi S, Benjamini S, Miyara S, Ruzal M, et al. Comparative omics and feeding manipulations in chicken indicate a shift of the endocrine role of visceral fat towards reproduction. BMC Genomics. 2018;19:295 pubmed publisher
    ..These comparisons revealed expression of new adipokines and secreted proteins (LCAT, LECT2, SERPINE2, SFTP1, ZP1, ZP3, APOV1, VTG1 and VTG2) at the mRNA and/or protein levels, with dynamic gene expression patterns ..
  24. Accordini S, Calciano L, Bombieri C, Malerba G, Belpinati F, Lo Presti A, et al. An Interleukin 13 Polymorphism Is Associated with Symptom Severity in Adult Subjects with Ever Asthma. PLoS ONE. 2016;11:e0151292 pubmed publisher
    ..in other gene regions showed a non-significant moderate association with STS (IL12B, TNS1) or lung function (SERPINE2, GATA3, IL5, NPNT, FAM13A) only...
  25. Izumo W, Higuchi R, Yazawa T, Uemura S, Matsunaga Y, Shiihara M, et al. A long-term recurrence-free survival of a patient with the mixed adeno-neuroendocrine bile duct carcinoma: A case report and review of the literature. Int J Surg Case Rep. 2017;39:43-50 pubmed publisher
    ..Therefore, the final diagnosis was MANEC, pT3, pN1, M0, pStage II B (TNM classification of the UICC)...
  26. Tarsitano A, Asioli S, Morandi L, Monti V, Righi A, Morselli Labate A, et al. Laminin-5 and insulin-like growth factor-II mRNA binding protein-3 (IMP3) expression in preoperative biopsy specimens from oral cancer patients: Their role in neural spread risk and survival stratification. J Craniomaxillofac Surg. 2016;44:1896-1902 pubmed publisher
    Perineural invasion (PNI) hinders the ability to establish local control of oral squamous cell carcinoma (OSCC)...
  27. Han M, Roh J, Choi S, Nam S, Lee H, Cho K, et al. Prognostic factors and outcome analysis of salivary duct carcinoma. Auris Nasus Larynx. 2015;42:472-7 pubmed publisher
    ..Advanced N classification and perineural invasion (PNI) were significant predictors of DFS and DMFS...
  28. Saloman J, Albers K, Li D, Hartman D, Crawford H, Muha E, et al. Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer. Proc Natl Acad Sci U S A. 2016;113:3078-83 pubmed publisher
    ..Sensory neuron ablation by neonatal capsaicin injection prevented perineural invasion (PNI), astrocyte activation, and neuronal damage, suggesting that sensory neurons convey inflammatory signals from Kras-..
  29. Goswami R, Anastakis D, Katz J, Davis K. A longitudinal study of pain, personality, and brain plasticity following peripheral nerve injury. Pain. 2016;157:729-39 pubmed publisher
    We do not know precisely why pain develops and becomes chronic after peripheral nerve injury (PNI), but it is likely due to biological and psychological factors...
  30. Hwang Y, Park I, Park S, Kim E, Kang C, Kim Y. Lymph Node Dissection in Thymic Malignancies: Implication of the ITMIG Lymph Node Map, TNM Stage Classification, and Recommendations. J Thorac Oncol. 2016;11:108-14 pubmed publisher
    ..The freedom from recurrence rate of the pN1/2 was significantly worse than that of the pN0 (5-year rate 38.5% versus 87.9%, p < 0.001)...
  31. Yeh C, Li W, Chu P, Kao S, Chen Y, Lee T, et al. Pretreatment pain predicts perineural invasion in oral squamous cell carcinoma: A prospective study. Oral Oncol. 2016;61:115-9 pubmed publisher
    Perineural invasion (PNI) is an established poor prognostic pathological feature for oral squamous cell carcinoma (OSCC). The purpose of this study was to analyze the role of pretreatment parameters in predicting PNI for OSCC...
  32. Meyers E, Granja R, Solorzano B, Romero Ortega M, Kilgard M, Rennaker R, et al. Median and ulnar nerve injuries reduce volitional forelimb strength in rats. Muscle Nerve. 2017;56:1149-1154 pubmed publisher
    Peripheral nerve injuries (PNI) are among the leading causes of physical disability in the United States. The majority of injuries occur in the upper extremities, and functional recovery is often limited...
  33. Liu C, Chang H, Wu T, Chen L, Yang Y, Tseng T, et al. Rearrangement of potassium ions and Kv1.1/Kv1.2 potassium channels in regenerating axons following end-to-end neurorrhaphy: ionic images from TOF-SIMS. Histochem Cell Biol. 2017;148:407-416 pubmed publisher
    ..potassium ion distribution at the node of Ranvier during the regenerative process of peripheral nerve injury (PNI). In the present study, end-to-end neurorrhaphy (EEN) was performed using an in vivo model of PNI...
  34. Lee B, Shapiro M, Rutledge J, Korst R. Nodal Upstaging in Robotic and Video Assisted Thoracic Surgery Lobectomy for Clinical N0 Lung Cancer. Ann Thorac Surg. 2015;100:229-33; discussion 233-4 pubmed publisher
    ..Within the VATS group, 24 patients experienced nodal upstaging (15.2%), with 13 patients having pN1 disease, and 11 patients having pN2 disease. The robotics group contained 7 patients (13...
  35. Tominaga T, Takeshita H, Takagi K, Kunizaki M, To K, Abo T, et al. E-PASS score as a useful predictor of postoperative complications and mortality after colorectal surgery in elderly patients. Int J Colorectal Dis. 2016;31:217-25 pubmed publisher
    ..and operative severity score for the enumeration of mortality (CR-POSSUM) and the prognostic nutritional index (PNI)] were also examined...
  36. Deng Y, Pang Q, Bi J, Zhang X, Zhang L, Zhou Y, et al. A promising prediction model for survival in gallbladder carcinoma patients: pretreatment prognostic nutrient index. Tumour Biol. 2016;: pubmed
    ..The aim of the study was to investigate whether preoperative prognostic nutritional index (PNI), which simply accounts for nutritional and immunological status, was associated with overall survival (OS) in ..
  37. Saitoh Y, Ströker E, Irfan G, Mugnai G, Ciconte G, Hünük B, et al. Fluoroscopic position of the second-generation cryoballoon during ablation in the right superior pulmonary vein as a predictor of phrenic nerve injury. Europace. 2016;18:1179-86 pubmed publisher
    Phrenic nerve injury (PNI) is the most frequently observed complication during pulmonary vein isolation procedure using the second-generation cryoballoon (CB)...
  38. Wakeam E, Giuliani M, Leighl N, Finlayson S, Varghese T, Darling G. Indications for Adjuvant Mediastinal Radiotherapy in Surgically Resected Small Cell Lung Cancer. Ann Thorac Surg. 2017;103:1647-1653 pubmed publisher
    ..Kaplan-Meier curves showed better median survival for patients with pN1 or pN2 disease who received AMR...
  39. Capitanio U, Deho F, Dell Oglio P, Larcher A, Capogrosso P, Nini A, et al. Lymphadenopathies in patients with renal cell carcinoma: clinical and pathological predictors of pathologically confirmed lymph node invasion. World J Urol. 2016;34:1139-45 pubmed publisher
    ..All lymphadenopathies were removed at surgery, and LNI was pathologically confirmed (pN1) in 122 patients (28.8 %)...
  40. Decaluwé H, Stanzi A, Dooms C, Fieuws S, Coosemans W, Depypere L, et al. Central tumour location should be considered when comparing N1 upstaging between thoracoscopic and open surgery for clinical stage I non-small-cell lung cancer. Eur J Cardiothorac Surg. 2016;50:110-7 pubmed publisher
    ..7, P = 0.99). Pathological nodal upstaging was found in 15.9% (n = 53) of cStage-I patients. Nodal pN1 and pN2 upstaging were 13.3 and 8.2%, respectively, for the open group, and 6.3 and 4...
  41. Harimoto N, Yoshizumi T, Shimagaki T, Nagatsu A, Motomura T, Harada N, et al. Inflammation-based Prognostic Score in Patients with Living Donor Liver Transplantation for Hepatocellular Carcinoma. Anticancer Res. 2016;36:5537-5542 pubmed
    ..NLR), platelet/lymphocyte ratio (PLR), modified Glasgow prognostic score (mGPS) and prognostic nutritional index (PNI) have prognostic value in various malignancies...
  42. Lee C, Su Y, Hung S, Chen P, Huang C, Huang W, et al. Recommendation for incorporation of a different lymph node scoring system in future AJCC N category for oral cancer. Sci Rep. 2017;7:14117 pubmed publisher
    ..Stage migration occurred in pN1 and pN2 patients with LODDS 4. In pN1 patients, those with LODDS 4 had the worst 5-year DSS (41.2%) and OS (31...
  43. Moon Y, Kim K, Lee K, Sung S, Kim Y, Park J. Clinicopathologic Factors Associated With Occult Lymph Node Metastasis in Patients With Clinically Diagnosed N0 Lung Adenocarcinoma. Ann Thorac Surg. 2016;101:1928-35 pubmed publisher
    ..by preoperative computed tomography scanning and positron emission tomography scanning was staged as pathologic N1 (pN1) or N2 (pN2) postoperatively...
  44. Harada M, Hara F, Hayashi K, Takarada Y. Assessment of left ventricular diastolic function using color kinesis: differentiation between normal and pseudonormalized patterns. J Med Ultrason (2001). 2009;36:69-75 pubmed publisher
    ..EF: (1) the normal group (e' > 10 cm/s, EF > 60%), including 20 subjects (mean age 35 ± 10 years); (2) the PN1 group (e' < 7 cm/s, EF > 50%), consisting of 20 patients [mean age 63 ± 11 years, 15 patients with ..
  45. Elfokery B, Tawfic S, Abdelrahman A, Abbas D, Abdelghaffar I. Comparative study on the analgesic effect of acute ipsilateral shoulder pain after open thoracotomy between preoperative ultrasound guided suprascapular nerve block (SNB) and intraoperative phrenic nerve infiltration (PNI) in cancer lung patients. J Egypt Natl Canc Inst. 2018;30:27-31 pubmed publisher
    ..study was designed to compare the effectiveness of suprascapular nerve block (SNB) and phrenic nerve infiltration (PNI) for controlling ISP...
  46. Gershman B, Thompson R, Moreira D, Boorjian S, Tollefson M, Lohse C, et al. Radical Nephrectomy With or Without Lymph Node Dissection for Nonmetastatic Renal Cell Carcinoma: A Propensity Score-based Analysis. Eur Urol. 2017;71:560-567 pubmed publisher
    ..A total of 111 (6.2%) patients were pN1. The median follow-up after surgery was 10.6 yr...
  47. Migita K, Matsumoto S, Wakatsuki K, Ito M, Kunishige T, Nakade H, et al. A decrease in the prognostic nutritional index is associated with a worse long-term outcome in gastric cancer patients undergoing neoadjuvant chemotherapy. Surg Today. 2017;47:1018-1026 pubmed publisher
    The aim of this study was to evaluate the prognostic impact of the prognostic nutritional index (PNI) in gastric cancer patients undergoing neoadjuvant chemotherapy (NAC)...
  48. Hirahara N, Tajima Y, Fujii Y, Kaji S, Yamamoto T, Hyakudomi R, et al. Preoperative Prognostic Nutritional Index Predicts Long-Term Surgical Outcomes in Patients with Esophageal Squamous Cell Carcinoma. World J Surg. 2018;42:2199-2208 pubmed publisher
    The purpose of the present study is to investigate the utility of prognostic nutritional index (PNI) as a simple and readily available marker in esophageal squamous cell carcinoma (ESCC)...
  49. Monard D. SERPINE2/Protease Nexin-1 in vivo multiple functions: Does the puzzle make sense?. Semin Cell Dev Biol. 2017;62:160-169 pubmed publisher
    Cultures of glial cells and fibroblasts allowed and lead to the identification SERPINE2/Protease Nexin-1 (SERPINE2/PN-1)...
  50. Okamura Y, Sugiura T, Ito T, Yamamoto Y, Ashida R, Uesaka K. The optimal cut-off value of the preoperative prognostic nutritional index for the survival differs according to the TNM stage in hepatocellular carcinoma. Surg Today. 2017;47:986-993 pubmed publisher
    To establish the optimal cut-off value of the preoperative prognostic nutritional index (PNI) for prognosis according to the Tumor Node Metastasis (TNM) stage of hepatocellular carcinoma (HCC) after curative resection...
  51. Peng J, Zhang R, Zhao Y, Wu X, Chen G, Wan D, et al. Prognostic value of preoperative prognostic nutritional index and its associations with systemic inflammatory response markers in patients with stage III colon cancer. Chin J Cancer. 2017;36:96 pubmed publisher
    The prognostic nutritional index (PNI) has been widely applied for predicting survival outcomes of patients with various malignant tumors...
  52. Noh G, Han J, Cho M, Hur H, Min B, Lee K, et al. Impact of the prognostic nutritional index on the recovery and long-term oncologic outcome of patients with colorectal cancer. J Cancer Res Clin Oncol. 2017;143:1235-1242 pubmed publisher
    The prognostic nutritional index (PNI) has been reported to be a predictive marker for surgical outcomes and prognosis in gastrointestinal malignancies...
  53. Tingting H, Di S, Xiaoping C, Xiaohong W, Dong H. High preoperative serum ferritin predicted poor prognosis in non-metastatic colorectal cancer. Saudi Med J. 2017;38:268-275 pubmed publisher
    ..Compared with peri-neural invasion (PNI)-negative patients, PNI-positive patients had higher serum iron (p=0.03) and ferritin levels (p=0.01)...
  54. Zhang W, Ye B, Liang W, Ren Y. Preoperative prognostic nutritional index is a powerful predictor of prognosis in patients with stage III ovarian cancer. Sci Rep. 2017;7:9548 pubmed publisher
    ..ratio (LMR), modified Glasgow prognostic score (mGPS), body mass index (BMI), and prognostic nutritional index (PNI)...
  55. Xia Q, Bai Q, Dong M, Sun X, Zhang H, Cui J, et al. Interaction Between Gastric Carcinoma Cells and Neural Cells Promotes Perineural Invasion by a Pathway Involving VCAM1. Dig Dis Sci. 2015;60:3283-92 pubmed publisher
    Perineural invasion (PNI) is one of the important routes for local spread of gastric carcinoma associated with poor prognosis. However, the exact cellular characteristics and molecular mechanisms of PNI are still unclear...
  56. Chen C, Gao X, Duan X, Chen B, Liu X, Xu Y. Comparison of catheter ablation for paroxysmal atrial fibrillation between cryoballoon and radiofrequency: a meta-analysis. J Interv Card Electrophysiol. 2017;48:351-366 pubmed publisher
    ..58; 95% confidence interval (CI), -0.85 to -0.30], complications without phrenic nerve injury (PNI) [odds ratio (OR)?=?0.79; 95% CI, 0.67-0.93; I 2?=?16%], and recrudescence (OR?=?0.83; 95% CI, 0.70-0...
  57. Bergeron S, Lemieux E, Durand V, Cagnol S, Carrier J, Lussier J, et al. The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis. Mol Cancer. 2010;9:271 pubmed publisher
    ..Results from microarrays comparing control to caMEK-expressing IECs identified the gene encoding for serpinE2, a serine protease inhibitor, as a potential target of activated MEK1...
  58. Yamauchi Y, Muley T, Safi S, Rieken S, Bischoff H, Kappes J, et al. The dynamic pattern of recurrence in curatively resected non-small cell lung cancer patients: Experiences at a single institution. Lung Cancer. 2015;90:224-9 pubmed publisher
    ..A comparison of histology and status of nodal involvement showed that pN1-2 adenocarcinoma patients demonstrated a high hazard rate of distant recurrence and that pN0 adenocarcinoma ..
  59. Harris B, Bayoumi A, Rao S, Moore M, Farwell D, Bewley A. Factors Associated with Recurrence and Regional Adenopathy for Head and Neck Cutaneous Squamous Cell Carcinoma. Otolaryngol Head Neck Surg. 2017;156:863-869 pubmed publisher
    ..2%. On Cox multivariate analysis, recurrent disease, perineural invasion (PNI), and poorly differentiated histology were independent predictors of recurrence...
  60. Mandel P, Kriegmair M, Bogdan K, Boehm K, Budaus L, Graefen M, et al. Association between Lymph Node Counts and Oncological Outcomes in Lymph Node Positive Prostate Cancer. Eur Urol Focus. 2017;3:248-255 pubmed publisher
    ..To investigate the association between total and positive lymph node (LN) counts and oncological outcomes in pN1 patients at RP...
  61. Okada S, Shimada J, Teramukai S, Kato D, Tsunezuka H, Miyata N, et al. Risk Stratification According to the Prognostic Nutritional Index for Predicting Postoperative Complications After Lung Cancer Surgery. Ann Surg Oncol. 2018;25:1254-1261 pubmed publisher
    The prognostic nutritional index (PNI), an immune nutritional marker based on serum albumin levels and total lymphocyte count, predicts postoperative complications in various types of malignancies...
  62. Boulaftali Y, Ho Tin Noe B, Pena A, Loyau S, Venisse L, François D, et al. Platelet protease nexin-1, a serpin that strongly influences fibrinolysis and thrombolysis. Circulation. 2011;123:1326-34 pubmed publisher
    ..Inhibition of PN-1 is thus predicted to promote endogenous and exogenous tissue plasminogen activator-mediated fibrinolysis and may enhance the therapeutic efficacy of thrombolytic agents. ..
  63. Wang K, Wang B, Xing A, Xu K, Li G, Yu Z. Prognostic significance of SERPINE2 in gastric cancer and its biological function in SGC7901 cells. J Cancer Res Clin Oncol. 2015;141:805-12 pubmed publisher
    Altered expression of serine protease inhibitor peptidase inhibitor clade E member 2 (SERPINE2) associates with human cancer development and progression; thus, this study investigated SERPINE2 expression in gastric cancer tissues for ..
  64. Ke B, Liu N, Zhang R, Guo X, Li B, Wang X, et al. [Analysis of lymph node metastasis pattern in gastric cancer patients at stage pN1]. Zhonghua Wei Chang Wai Ke Za Zhi. 2017;20:782-786 pubmed
    To investigate the lymph node metastasis pattern in pN1 stage gastric cancer patients and to analyze its risk factors...
  65. Hempel S, Plodeck V, Mierke F, Distler M, Aust D, Saeger H, et al. Para-aortic lymph node metastases in pancreatic cancer should not be considered a watershed for curative resection. Sci Rep. 2017;7:7688 pubmed publisher
    ..2 months, respectively. Five of the PALN+ patients (36%) survived >19 months. The OS of PALN+ and those staged pN1 PALN- was not significantly different (P = 0.743)...
  66. Shirakabe A, Hata N, Kobayashi N, Okazaki H, Matsushita M, Shibata Y, et al. The prognostic impact of malnutrition in patients with severely decompensated acute heart failure, as assessed using the Prognostic Nutritional Index (PNI) and Controlling Nutritional Status (CONUT) score. Heart Vessels. 2018;33:134-144 pubmed publisher
    ..A total of 458 HF patients were enrolled in this study. The Prognostic Nutritional Index (PNI) is calculated as 10 × serum albumin (g/dL) + 0...
  67. García Novoa A, Acea Nebril B. Treatment of the axila in breast cancer surgery: Systematic review of its impact on survival. Cir Esp. 2017;95:503-512 pubmed publisher
    ..In patients pN1 it is proposed not to treat the axilla or replace ALND for axillary radiotherapy...
  68. Chang K, Lin Y, Lin C, Tsai M, Huang W, Shih Y, et al. Data on the expression of leptin and leptin receptor in the dorsal root ganglion and spinal cord after preganglionic cervical root avulsion. Data Brief. 2017;15:567-572 pubmed publisher
    ..also a proinflammatory factor and involved in the development of neuropathic pain after peripheral nerve injuries (PNI) (Lim et al., 2009; Maeda et al., 2009) [1,2]...
  69. Tang S, Deng S, Guo J, Chen X, Zhang W, Cui Y, et al. Deep Coverage Tissue and Cellular Proteomics Revealed IL-1? Can Independently Induce the Secretion of TNF-Associated Proteins from Human Synoviocytes. J Immunol. 2018;200:821-833 pubmed publisher
    ..suppressing HS endocytosis, IL-1? could activate the secretion of 25 TNF-associated proteins, and the change of SERPINE2 and COL3A1 secretion was verified by immunoblotting...
  70. Sørheim I, Gulsvik A. Genetics of chronic obstructive pulmonary disease: a case-control study in Bergen, Norway. Clin Respir J. 2008;2 Suppl 1:129-31 pubmed publisher
    ..This short communication gives a description of the preliminary genetic results from a case-control study in Bergen, Norway...
  71. Kukkonen M, Tiili E, Hämäläinen S, Vehmas T, Oksa P, Piirilä P, et al. SERPINE2 haplotype as a risk factor for panlobular type of emphysema. BMC Med Genet. 2011;12:157 pubmed publisher
    b>SERPINE2 (serpin peptidase inhibitor, clade E, member 2) has previously been identified as a positional candidate gene for chronic obstructive pulmonary disease (COPD) and has subsequently been associated to COPD and emphysema in several ..
  72. McKee C, Xu D, Cao Y, Kabraji S, Allen D, Kersemans V, et al. Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma. J Clin Invest. 2012;122:4025-36 pubmed publisher
    ..Here, we identify the serine protease inhibitor protease nexin 1 (PN1) as a negative regulator of Hh signaling in prostate...
  73. Ahmad J, Grimes N, Farid S, Morris Stiff G. Inflammatory response related scoring systems in assessing the prognosis of patients with pancreatic ductal adenocarcinoma: a systematic review. Hepatobiliary Pancreat Dis Int. 2014;13:474-81 pubmed
    ..version (mGPS), platelet lymphocyte ratio (PLR), neutrophil lymphocyte ratio (NLR), and prognostic nutrition index (PNI)...
  74. Vaillant C, Valdivieso P, Nuciforo S, Kool M, Schwarzentruber Schauerte A, Méreau H, et al. Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma. PLoS ONE. 2015;10:e0124870 pubmed publisher
    ..Transcriptome analysis of human medulloblastomas shows that SERPINE2, also called Protease Nexin-1 (PN-1) is overexpressed in most medulloblastomas, in particular in the SHH and WNT ..
  75. Sun W, Lv W, Lv H, Zhang R, Jiang Y. Genome-wide haplotype association analysis identifies SERPINB9, SERPINE2, GAK, and HSP90B1 as novel risk genes for oral squamous cell carcinoma. Tumour Biol. 2016;37:1845-51 pubmed publisher
    ..We filtered four OSCC genes including SERPINB9, SERPINE2, GAK, and HSP90B1 through the gene global prioritization score (P < 0.005)...
  76. Mao M, Wang W. SerpinE2 promotes multiple cell proliferation and drug resistance in osteosarcoma. Mol Med Rep. 2016;14:881-7 pubmed publisher
    b>SerpinE2 is a member of the Serpins family, which could inhibit serine protease and promote tumor progression, particularly in tumor metastasis. However, at present, its role in the progression of osteosarcoma has not been determined...
  77. Stepien T, Brożyna M, Kuzdak K, Motylewska E, Komorowski J, Stepien H, et al. Elevated Concentrations of SERPINE2/Protease Nexin-1 and Secretory Leukocyte Protease Inhibitor in the Serum of Patients with Papillary Thyroid Cancer. Dis Markers. 2017;2017:4962137 pubmed publisher
    i>Introduction. SERPINE2 and secretory leukocyte protease inhibitor (SLPI) are proteins with anticoagulant properties which could promote solid tumor growth...
  78. Zhang Y, Zhan Y, Han N, Kou Y, Yin X, Zhang P. Analysis of temporal expression profiles after sciatic nerve injury by bioinformatic method. Sci Rep. 2017;7:9818 pubmed publisher
    After Peripheral nerve injuries (PNI), many complicated pathophysiologic processes will happen. A global view of functional changes following PNI is essential for the looking for the adequate therapeutic approaches...
  79. van Vugt V, Saria M, Javier A, Kesari N, Turpin T, Kesari S. Neurological improvement of perineural and leptomeningeal spread of squamous cell carcinoma treated with intrathecal chemotherapy and systemic EGFR inhibition. CNS Oncol. 2017;6:269-274 pubmed publisher
    ..Perineural invasion (PNI), an uncommon manifestation of SCC, involves microscopic tumor cells invading various layers of the nerve sheath...
  80. Kanazawa Y, Fujita I, Kakinuma D, Aoki Y, Kanno H, Arai H, et al. Five-year Survival After Surgical Removal and Gamma Knife Stereotactic Radiosurgery for a Cerebellar Metastasis from an Esophagogastric Junction Cancer: A Case Report and Literature Review. In Vivo. 2017;31:1209-1214 pubmed
    ..It was diagnosed as a esophagogastric junction Siewert type II tumor, type 3, tub1-2, pT3 (SS), pN1, and stage IIB on histopathological examination of the surgical specimen...
  81. Boukais K, Borges L, Venisse L, Touat Z, François D, Arocas V, et al. Clearance of plasmin-PN-1 complexes by vascular smooth muscle cells in human aneurysm of the ascending aorta. Cardiovasc Pathol. 2018;32:15-25 pubmed publisher
    ..Thus, two complementary mechanisms are involved in the protective role of PN-1 in human TAA: one involving plasmin inhibition and the other involving tissue clearance of plasmin-PN1 complexes via the scavenger receptor LRP-1.
  82. Nykjaer A, Conese M, Christensen E, Olson D, Cremona O, Gliemann J, et al. Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes. EMBO J. 1997;16:2610-20 pubmed
  83. Dema B, Martinez A, Fernandez Arquero M, Maluenda C, Polanco I, de la Concha E, et al. Lack of replication of celiac disease risk variants reported in a Spanish population using an independent Spanish sample. Genes Immun. 2009;10:659-61 pubmed publisher
    ..Polymorphisms in three genes, SERPINE2, PPP6C and PBX3, have recently been associated with CD in the Spanish population...
  84. Wang A, Yin Y, Chen P, Liu Q, Yu Q, Xiao W. The association of SERPINE2 gene with COPD in a Chinese Han population. Yonsei Med J. 2011;52:953-60 pubmed publisher
    ..One such candidate is the SERPINE2 (Serpin peptidase inhibitor, clade E member 2) gene...
  85. Fossati A, Somma A, Pincus A, Borroni S, Dowgwillo E. Differentiating Community Dwellers at Risk for Pathological Narcissism From Community Dwellers at Risk for Psychopathy Using Measures of Emotion Recognition and Subjective Emotional Activation. J Pers Disord. 2017;31:325-345 pubmed publisher
    The Italian translations of the Pathological Narcissism Inventory (PNI) and Triarchic Psychopathy Measure (TriPM) were administered to 609 community dwelling adults...
  86. Taylor A, Mehrabani S, Liu S, Taylor A, Cahill C. Topography of microglial activation in sensory- and affect-related brain regions in chronic pain. J Neurosci Res. 2017;95:1330-1335 pubmed publisher
    ..cord plays a central role in the development and maintenance of chronic pain after a peripheral nerve injury (PNI)...
  87. Zhan K, Eskander A, Kang S, Old M, Ozer E, Agrawal A, et al. Appraisal of the AJCC 8th edition pathologic staging modifications for HPV-positive oropharyngeal cancer, a study of the National Cancer Data Base. Oral Oncol. 2017;73:152-159 pubmed publisher
    ..Distribution of stage I disease increased from 3.7% to 80.2% in AJCC 8th. pN1 disease shifted from 17.3% to 75.9%. Treatment and distribution of T-stage varied by pathologic nodal (pN) staging...
  88. Bakst R, Xiong H, Chen C, Deborde S, Lyubchik A, Zhou Y, et al. Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression. Cancer Res. 2017;77:6400-6414 pubmed publisher
    Perineural invasion (PNI) is an ominous event strongly linked to poor clinical outcome...
  89. Lee S, Park I, Park S, Sohn J, Jeong J, Ahn S, et al. Meeting Highlights: The Second Consensus Conference for Breast Cancer Treatment in Korea. J Breast Cancer. 2017;20:228-233 pubmed publisher
    ..voted on issues regarding surgical treatment for non-axillary regional lymph nodes, regional nodal irradiation of pN1 disease, and ovarian functional suppression (OFS) as an adjuvant treatment in premenopausal patients with hormone ..
  90. Kang M, Chang C, Sung H, Jeon H, Jeong B, Seo S, et al. Prognostic Significance of Pre- to Postoperative Dynamics of the Prognostic Nutritional Index for Patients with Renal Cell Carcinoma Who Underwent Radical Nephrectomy. Ann Surg Oncol. 2017;24:4067-4075 pubmed publisher
    This study aimed to examine the prognostic role of Prognostic Nutritional Index (PNI) dynamics in the pre- and postoperative periods for patients with renal cell carcinoma (RCC) who undergo radical nephrectomy (RN)...
  91. Ren H, Wu L, Hu W, Ye X, Yu B. Prognostic value of the c-reactive protein/prognostic nutritional index ratio after hip fracture surgery in the elderly population. Oncotarget. 2017;8:61365-61372 pubmed publisher
    ..However, the mortality rate is high. Prognostic nutritional index (PNI) is associated with prognosis in hip fracture patients...
  92. Yang S, Kim H, Lee K, Hwang S, Lim E, Jung J, et al. Attomolar detection of extracellular microRNAs released from living prostate cancer cells by a plasmonic nanowire interstice sensor. Nanoscale. 2017;9:17387-17395 pubmed publisher
    ..an attomolar detection of miR141 and miR375 released from living PC cells by using a plasmonic nanowire interstice (PNI) sensor...