SERPINB2

Summary

Gene Symbol: SERPINB2
Description: serpin family B member 2
Alias: HsT1201, PAI, PAI-2, PAI2, PLANH2, plasminogen activator inhibitor 2, monocyte Arg-serpin, placental plasminogen activator inhibitor, plasminogen activator inhibitor, type II (arginine-serpin), serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2, serpin B2, serpin peptidase inhibitor, clade B (ovalbumin), member 2, urokinase inhibitor
Species: human
Products:     SERPINB2

Top Publications

  1. Varro A, Hemers E, Archer D, Pagliocca A, Haigh C, Ahmed S, et al. Identification of plasminogen activator inhibitor-2 as a gastrin-regulated gene: Role of Rho GTPase and menin. Gastroenterology. 2002;123:271-80 pubmed
    ..Gene expression was studied using promoter-luciferase reporter constructs. Plasminogen activator inhibitor 2 (PAI-2) was identified as a major, previously unknown target of gastrin in the gastric cancer cell ..
  2. Darnell G, Schroder W, Gardner J, Harrich D, Yu H, Medcalf R, et al. SerpinB2 is an inducible host factor involved in enhancing HIV-1 transcription and replication. J Biol Chem. 2006;281:31348-58 pubmed
    The serine protease inhibitor SerpinB2 (plasminogen activator inhibitor-2) is a major product of activated monocytes and macrophages and is substantially induced during most inflammatory processes...
  3. Lee J, Croucher D, Ranson M. Differential endocytosis of tissue plasminogen activator by serpins PAI-1 and PAI-2 on human peripheral blood monocytes. Thromb Haemost. 2010;104:1133-42 pubmed publisher
    ..this proteolytic cascade is exerted by the plasminogen activator inhibitors type-1 (PAI-1/SERPINE1) and 2 (PAI-2/SERPINB2)...
  4. Major L, Schroder W, Gardner J, Fish R, Suhrbier A. Human papilloma virus transformed CaSki cells constitutively express high levels of functional SerpinB2. Exp Cell Res. 2011;317:338-47 pubmed publisher
    Many malignant tissues, including human papilloma virus (HPV)-associated cancers, express SerpinB2, also known as plasminogen activator inhibitor type-2 (PAI-2)...
  5. Almeida Vega S, Catlow K, Kenny S, Dimaline R, Varro A. Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and ASC-1. Am J Physiol Gastrointest Liver Physiol. 2009;296:G414-23 pubmed publisher
    ..One putative target is plasminogen activator inhibitor-2 (PAI-2), which is a component of the urokinase activator system that acts extracellularly to inhibit urokinase ..
  6. Boncela J, Przygodzka P, Papiewska Pajak I, Wyroba E, Cierniewski C. Association of plasminogen activator inhibitor type 2 (PAI-2) with proteasome within endothelial cells activated with inflammatory stimuli. J Biol Chem. 2011;286:43164-71 pubmed publisher
    Quiescent endothelial cells contain low concentrations of plasminogen activator inhibitor type 2 (PAI-2). However, its synthesis can be rapidly stimulated by a variety of inflammatory mediators...
  7. Fang L, Liu J, Wan L, Zhu F, Tan B, Zhang P. [Xinfeng capsule improves hypercoagulative state by inhibiting miR-155/NF-?B signaling pathway in patients with active ankylosing spondylitis]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016;32:1094-8 pubmed
    ..granular membrane protein 140 (GMP140), platelet activation factor (PAF), and plasminogen activator inhibitor-2 (PAI-2) were determined by ELISA. Clinical efficacy was evaluated in the two groups...
  8. Guo T, Zhang L, Konermann A, Zhou H, Jin F, Liu W. Manganese superoxide dismutase is required to maintain osteoclast differentiation and function under static force. Sci Rep. 2015;5:8016 pubmed publisher
    ..The five proteins identified were plasminogen activator inhibitor 2 (PAI-2, Spot 1), peroxiredoxin-6 (PRD-6, Spot 3), manganese superoxide dismutase (SOD2, Spot 6), Rho ..
  9. Hall J, Pehrson N, Ekestubbe A, Jemt T, Friberg B. A controlled, cross-sectional exploratory study on markers for the plasminogen system and inflammation in crevicular fluid samples from healthy, mucositis and peri-implantitis sites. Eur J Oral Implantol. 2015;8:153-66 pubmed
    ..interleukin-1 beta (IL-1β), interleukin 8 (IL-8), tissue plasminogen activator (tPA), plasminogen activator inhibitor 2 (PAI-2), tartrate-resistant acid phosphatase (TRAP) and cathepsin K (CatK)...

More Information

Publications142 found, 100 shown here

  1. Al Horani R. Serpin regulation of fibrinolytic system: implications for therapeutic applications in cardiovascular diseases. Cardiovasc Hematol Agents Med Chem. 2014;12:91-125 pubmed
    ..mainly by α2-antiplasmin (α2-AP) or at the level of the PAs, mainly by plasminogen activator inhibitor -1 (PAI-1)...
  2. Joy J, Armstrong L, Ardill J, McClure N, Cooke I. Biochemical markers of placental dysfunction in assisted conception. Hum Fertil (Camb). 2015;18:282-90 pubmed publisher
    ..fms-like tyrosine kinase1 (sFlt1); (ii) placental growth factor (PlGF); (iii) leptin; and (iv) plasminogen activator inhibitor 2 (PAI-2), serially at four antenatal time points...
  3. Joseph K, Tholanikunnel B, Wolf B, Bork K, Kaplan A. Deficiency of plasminogen activator inhibitor 2 in plasma of patients with hereditary angioedema with normal C1 inhibitor levels. J Allergy Clin Immunol. 2016;137:1822-1829.e1 pubmed publisher
    ..Plasminogen activator inhibitors (PAIs) 1 and 2 were also measured by means of ELISA. PAI-1 levels varied from 0.1 to 4.5 ng/mL (mean, 2.4 ng/mL) in 23 control subjects, from 0.0 to 2 ng/mL (mean, 0...
  4. Belfiore L, Spenkelink L, Ranson M, van Oijen A, Vine K. Quantification of ligand density and stoichiometry on the surface of liposomes using single-molecule fluorescence imaging. J Control Release. 2018;278:80-86 pubmed publisher
    ..human proteins previously validated to target the cancer cell surface biomarkers plasminogen activator inhibitor-2 (PAI-2) and trastuzumab (TZ, Herceptin®)...
  5. Cardoso A, Fernandes A, Aguilar Pimentel J, de Angelis M, Guedes J, Brito M, et al. Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. Ageing Res Rev. 2018;47:214-277 pubmed publisher
    ..lactate dehydrogenase), (3) S100B (S100 calcium binding protein B), (4) TGFβ (transforming growth factor beta), PAI-1 (plasminogen activator inhibitor 1), TGM2 (transglutaminase 2), (5) sRAGE (soluble receptor for advanced ..
  6. Schatz F, Guzeloglu Kayisli O, Arlier S, Kayisli U, Lockwood C. The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding. Hum Reprod Update. 2016;22:497-515 pubmed publisher
    ..HESCs) increases in vivo and in vitro expression of tissue factor (TF) and type-1 plasminogen activator inhibitor (PAI-1) while inhibiting plasminogen activators (PAs), matrix metalloproteinases (MMPs), and the vasoconstrictor, ..
  7. Dutkiewicz J, Zając V, Sroka J, Wasiński B, Cisak E, Sawczyn A, et al. Streptococcus suis: a re-emerging pathogen associated with occupational exposure to pigs or pork products. Part II - Pathogenesis. Ann Agric Environ Med. 2018;25:186-203 pubmed publisher
    ..suis</i> pathogenicity, the most important are pathogenicity islands (PAI), in particular, a novel DNA segment of 89 kb length with evident pathogenic traits that has been designated as 89K ..
  8. Albert V, Arulselvi S, Agrawal D, Pati H, Pandey R. Early posttraumatic changes in coagulation and fibrinolysis systems in isolated severe traumatic brain injury patients and its influence on immediate outcome. Hematol Oncol Stem Cell Ther. 2018;: pubmed publisher
    ..TAT), soluble fibrin monomer (sFM), tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) was done...
  9. Zhang S, Wotzkow C, Bongoni A, Shaw Boden J, Siegrist M, Taddeo A, et al. Role of the plasma cascade systems in ischemia/reperfusion injury of bone. Bone. 2017;97:278-286 pubmed publisher
    ..as well as expression of tissue factor (TF), tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), and E-selectin was detected by immunohistochemistry...
  10. Gu J, Chen J, Yang N, Hou X, Wang J, Tan X, et al. Combination of Ligusticum chuanxiong and Radix Paeoniae ameliorate focal cerebral ischemic in MCAO rats via endoplasmic reticulum stress-dependent apoptotic signaling pathway. J Ethnopharmacol. 2016;187:313-24 pubmed publisher
    ..LPO and MDA were detected by commercial kits while ELISA kits for the content of plasminogen activator inhibitor-1 (PAI-1) and plasminogen activator (PA)...
  11. Du Y, Wang L, Qian J, Zhang K, Chai K. Panax notoginseng saponins protect kidney from diabetes by up-regulating silent information regulator 1 and activating antioxidant proteins in rats. Chin J Integr Med. 2016;22:910-917 pubmed
    ..protein-1 (MCP-1), transforming growth factor β1 (TGF-β1) and plasminogen activator inhibitor-1 (PAI-1) were analyzed by reverse transcription polymerase chain reaction...
  12. Upadhyay S, Stoeger T, George L, Schladweiler M, Kodavanti U, Ganguly K, et al. Ultrafine carbon particle mediated cardiovascular impairment of aged spontaneously hypertensive rats. Part Fibre Toxicol. 2014;11:36 pubmed publisher
    ..1 (ET1), endothelin receptors A, B (ETA, ETB), tissue factor (TF), and plasminogen activator inhibitor-1 (PAI-1) were measured in the lung and heart to assess oxidative stress, endothelial dysfunction and coagulation cascade...
  13. Liu Y, Li L, Fu J, Kao K, Huang C, Chien Y, et al. Induced pluripotent stem cell therapy ameliorates hyperoxia-augmented ventilator-induced lung injury through suppressing the Src pathway. PLoS ONE. 2014;9:e109953 pubmed publisher
    ..neutrophil infiltration, macrophage inflammatory protein-2 (MIP-2) and plasminogen activator inhibitor-1 (PAI-1) production, Src activation, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity, and ..
  14. Park E, Kim Y, Kim H, Jang S, Oh M, Lee D, et al. (S)YS-51, a novel isoquinoline alkaloid, attenuates obesity-associated non-alcoholic fatty liver disease in mice by suppressing lipogenesis, inflammation and coagulation. Eur J Pharmacol. 2016;788:200-209 pubmed publisher
    ..type 1 mRNA, macrophage infiltration] and coagulation [tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) mRNA and thrombin antithrombin complex (TAT)] in the liver, adipose tissue and serum, which were significantly ..
  15. Waschki B, Watz H, Holz O, Magnussen H, Olejnicka B, Welte T, et al. Plasminogen activator inhibitor-1 is elevated in patients with COPD independent of metabolic and cardiovascular function. Int J Chron Obstruct Pulmon Dis. 2017;12:981-987 pubmed publisher
    Plasminogen activator inhibitor-1 (PAI-1), a major inhibitor of fibrinolysis, is associated with thrombosis, obesity, insulin resistance, dyslipidemia, and premature aging, which all are coexisting conditions of chronic obstructive ..
  16. Li Z, Hong Z, Peng Z, Zhao Y, Shao R. Acetylshikonin from Zicao ameliorates renal dysfunction and fibrosis in diabetic mice by inhibiting TGF-?1/Smad pathway. Hum Cell. 2018;31:199-209 pubmed publisher
    ..The increased expression of fibrosis proteins, such as plasminogen activator inhibitor type 1 (PAI-1), connective tissue growth factor, and collagen III and IV, were reduced after acetylshikonin administration...
  17. Liu X, Hakucho A, Liu J, Fujimiya T. Delayed ethanol elimination and enhanced susceptibility to ethanol-induced hepatosteatosis after liver resection. World J Gastroenterol. 2014;20:18249-59 pubmed publisher
    ..proliferator-activated receptor (Ppar)-α], the mediators that alter lipid metabolism [plasminogen activator (Pai)-1 gene expression level and tumor necrosis factor (Tnf)-α production], and hepatic class-1 alcohol ..
  18. Qin G, Zhou Y, Guo F, Ren L, Wu L, Zhang Y, et al. Overexpression of the FoxO1 Ameliorates Mesangial Cell Dysfunction in Male Diabetic Rats. Mol Endocrinol. 2015;29:1080-91 pubmed
    ..Up-regulation of fibronectin, collagen type IV, and plasminogen activator inhibitor (PAI-1) was observed under HG conditions in vivo and in vitro, accompanied with elevation of protein kinase B (Akt) ..
  19. Bautista Niño P, Portilla Fernandez E, Vaughan D, Danser A, Roks A. DNA Damage: A Main Determinant of Vascular Aging. Int J Mol Sci. 2016;17: pubmed publisher
    ..apoptosis, senescence, autophagy), mediators of senescence and cell growth (plasminogen activator inhibitor-1 (PAI-1), cyclin-dependent kinase inhibitors, senescence-associated secretory phenotype (SASP)/senescence-messaging ..
  20. Zhou G, Wu J, Gu C, Wang B, Abel E, Cheung A, et al. Prorenin independently causes hypertension and renal and cardiac fibrosis in cyp1a1-prorenin transgenic rats. Clin Sci (Lond). 2018;132:1345-1363 pubmed publisher
    ..with increased expression of transforming growth factor ? (TGF?) 1 (TGF?1), plasminogen activator inhibitor-1 (PAI-1), collagen, and fibronectin (FN)...
  21. Nemmar A, Beegam S, Yuvaraju P, Yasin J, Tariq S, Attoub S, et al. Ultrasmall superparamagnetic iron oxide nanoparticles acutely promote thrombosis and cardiac oxidative stress and DNA damage in mice. Part Fibre Toxicol. 2016;13:22 pubmed publisher
    ..effect in pial arterioles and venules in vivo and increased the plasma plasminogen activator inhibitor-1 (PAI-1). Both thrombogenicity and PAI-1 concentration were increased by DEP. The direct addition of USPIO (0.008, 0...
  22. Tian L, Li H, Li Y, Liu K, Sun Y, Cong Z, et al. A Combination of Chitosan, Cellulose, and Seaweed Polysaccharide Inhibits Postoperative Intra-abdominal Adhesion in Rats. J Pharmacol Exp Ther. 2018;364:399-408 pubmed publisher
    ..of fibrosis) and its downstream factors-namely, alpha-smooth muscle actin and plasminogen activator inhibitor-1 (PAI-1)-were effectively suppressed by CCS in vivo, and as a result, the activation of tissue plasminogen activator (tPA,..
  23. Reynolds L, Pollack R, Charnigo R, Rashid C, Stromberg A, Shen S, et al. Increased birth weight is associated with altered gene expression in neonatal foreskin. J Dev Orig Health Dis. 2017;8:575-583 pubmed publisher
    ..receptor-related protein 1 (LRP1), matrix metalloproteinase 2 (MMP2), plasminogen activator inhibitor-1 (PAI-1) and transcription factor 7-like 2 (TCF7L2) were significantly upregulated and histone deacetylase 1 (HDAC1) and ..
  24. Reine T, Kolseth I, Meen A, Lindahl J, Jenssen T, Reinholt F, et al. Effects of restoring normoglycemia in type 1 diabetes on inflammatory profile and renal extracellular matrix structure after simultaneous pancreas and kidney transplantation. Diabetes Res Clin Pract. 2015;107:46-53 pubmed publisher
    ..Plasminogen activator inhibitor (PAI-1), C-reactive protein (CRP) and vascular endothelial growth factor (VEGF) were lower in the SPK group...
  25. Aumailley L, Dubois M, Garand C, Marette A, Lebel M. Impact of vitamin C on the cardiometabolic and inflammatory profiles of mice lacking a functional Werner syndrome protein helicase. Exp Gerontol. 2015;72:192-203 pubmed publisher
    ..We show that young mutant mice exhibit an increase in serum hydroxyproline and plasminogen activator inhibitor-1 (PAI-1), markers of cardiovascular diseases and inflammation, before they exhibit morphological anomalies in different ..
  26. Ku S, Yoon E, Lee W, Kwon S, Lee T, Bae J. Antithrombotic and antiplatelet activities of pelargonidin in vivo and in vitro. Arch Pharm Res. 2016;39:398-408 pubmed publisher
    ..on the fibrin polymerization, platelet aggregation, and the ratio of plasminogen activator inhibitor-1 (PAI-1) to tissue plasminogen activator were determined...
  27. Kolseth I, Reine T, Parker K, Sudworth A, Witczak B, Jenssen T, et al. Increased levels of inflammatory mediators and proinflammatory monocytes in patients with type I diabetes mellitus and nephropathy. J Diabetes Complications. 2017;31:245-252 pubmed publisher
    ..Patients with nephropathy had increased plasma levels of proinflammatory monocytes, as well as circulatory PAI-1, syndecan-1, VEGF, IL-1β, IL-1Ra and CCL4...
  28. Martin G, Pugh T, Mahmood U, Kudchadker R, Wang J, Bruno T, et al. Permanent prostate brachytherapy pubic arch evaluation with diagnostic magnetic resonance imaging. Brachytherapy. 2017;16:728-733 pubmed publisher
    Pubic arch interference (PAI), when it occurs, is often a limiting factor for patients pursuing brachytherapy treatment of prostate cancer...
  29. Boe A, Eren M, Murphy S, Kamide C, Ichimura A, Terry D, et al. Plasminogen activator inhibitor-1 antagonist TM5441 attenuates N?-nitro-L-arginine methyl ester-induced hypertension and vascular senescence. Circulation. 2013;128:2318-24 pubmed publisher
    ..We previously reported that plasminogen activator inhibitor-1 (PAI-1)-deficient mice (PAI-1(-/-)) are protected against L-NAME-induced pathologies...
  30. Sun H, Mi X, Gao N, Yan C, Yu F. Hyperglycemia-suppressed expression of Serpine1 contributes to delayed epithelial wound healing in diabetic mouse corneas. Invest Ophthalmol Vis Sci. 2015;56:3383-92 pubmed publisher
    ..Enzyme assay for matrix metalloproteinase (MMP)-3 was also performed. The expressions of Serpine1 (PAI-1), Plau (uPA), and Plaur (uPA receptor) were upregulated in response to wounding, and these upregulations were ..
  31. Sipilä K, Ranga V, Rappu P, Torittu A, Pirilä L, Käpylä J, et al. Extracellular citrullination inhibits the function of matrix associated TGF-β. Matrix Biol. 2016;55:77-89 pubmed publisher
    ..cell derived matrix, rich with TGF-β, decreased the level of TGF-β activity as detected by HaCaT and MLEC-PAI-1/Lu reporter cells...
  32. Hariri A, Lemaster J, Wang J, Jeevarathinam A, Chao D, Jokerst J. The characterization of an economic and portable LED-based photoacoustic imaging system to facilitate molecular imaging. Photoacoustics. 2018;9:10-20 pubmed publisher
    Photoacoustic imaging (PAI) is a non-invasive, high-resolution hybrid imaging modality that combines optical excitation and ultrasound detection. PAI can image endogenous chromophores (melanin, hemoglobin, etc...
  33. Castro M, Massa M, Arbeláez L, Schinella G, Gagliardino J, Francini F. Fructose-induced inflammation, insulin resistance and oxidative stress: A liver pathological triad effectively disrupted by lipoic acid. Life Sci. 2015;137:1-6 pubmed publisher
    ..Matsuda indices compared to control animals, together with increased oxidative stress markers, TNFα, IL1β and PAI-1 gene expression, and TNFα and COX-2 protein content...
  34. Letson H, Dobson G. Differential contributions of platelets and fibrinogen to early coagulopathy in a rat model of hemorrhagic shock. Thromb Res. 2016;141:58-65 pubmed publisher
    ..coagulopathy, with fibrinolysis, was supported by ≥15% in maximum lysis (ML), a threefold increase in plasma PAI-1 after hemorrhage, and undetectable levels after shock...
  35. Sumiyoshi M, Kimura Y. Effects of a High-Fat or High-Sucrose Diet on Ultraviolet B Irradiation-Induced Carcinogenesis and Tumor Growth in Melanin-Possessing Hairless Mice. Nutr Cancer. 2016;68:791-803 pubmed publisher
    ..development and growth, increased skin matrix metalloproteinase (MMP) and blood plasminogen activator inhibitor-1 (PAI-1) levels, and decreased blood leptin and adiponectin levels after long-term UVB irradiation...
  36. Le Sage F, Meilhac O, Gonthier M. Anti-inflammatory and antioxidant effects of polyphenols extracted from Antirhea borbonica medicinal plant on adipocytes exposed to Porphyromonas gingivalis and Escherichia coli lipopolysaccharides. Pharmacol Res. 2017;119:303-312 pubmed publisher
    ..enhanced the production of Toll-like receptor-dependent MyD88 and NF?B signaling factors as well as IL-6, MCP-1, PAI-1 and resistin. Plant polyphenols reduced LPS pro-inflammatory action...
  37. Xie M, Wu X, Zhang J, Zhang J, Li X. Ski regulates Smads and TAZ signaling to suppress lung cancer progression. Mol Carcinog. 2017;56:2178-2189 pubmed publisher
    ..of Ski re-activation on TGF-β and Hippo/TAZ pathway, we measured its effect on the endogenous Smad target genes (PAI-1 and P15INK4B ) and TAZ target gene CTGF...
  38. Siudut J, Natorska J, Zabczyk M, Zajac D, Seweryn K, Rapała Kozik M, et al. Impaired plasminogen binding in patients with venous thromboembolism: Association with protein carbonylation. Thromb Res. 2018;163:12-18 pubmed publisher
    ..43, p=0.037), tissue plasminogen activator-plasminogen activator inhibitor 1 (tPA-PAI-1) complexes (r=0.63, p=0.012), and active PAI-1 (r=0.49, p=0.03)...
  39. Tomasik J, Schultz T, Kluge W, Yolken R, Bahn S, Carruthers V. Shared Immune and Repair Markers During Experimental Toxoplasma Chronic Brain Infection and Schizophrenia. Schizophr Bull. 2016;42:386-95 pubmed publisher
    ..protein (CRP), interleukin-1 beta (IL-1β), interferon gamma (IFNγ), plasminogen activator inhibitor 1 (PAI-1), tissue inhibitor of metalloproteinases 1 (TIMP-1), and vascular cell adhesion molecule 1 (VCAM-1)...
  40. Stubblefield W, Alves N, Rondina M, Kline J. Variable Resistance to Plasminogen Activator Initiated Fibrinolysis for Intermediate-Risk Pulmonary Embolism. PLoS ONE. 2016;11:e0148747 pubmed publisher
    ..plasminogen, thrombin activatable fibrinolysis inhibitor (TAFI), plasminogen activator Inhibitor 1 (PAI-1), thrombin time and D-dimer were quantified. Clotting was induced using CaCl2, tissue factor, and phospholipid...
  41. Nieto P, Pardo Roa C, Salazar Echegarai F, Tobar H, Coronado Arrázola I, Riedel C, et al. New insights about excisable pathogenicity islands in Salmonella and their contribution to virulence. Microbes Infect. 2016;18:302-9 pubmed publisher
    ..Understanding the role of PAI excision could provide important insights relative to the emergence, evolution and virulence of pathogenic ..
  42. Yang H, Tsai Y, Korivi M, Chang C, Hseu Y. Lucidone Promotes the Cutaneous Wound Healing Process via Activation of the PI3K/AKT, Wnt/?-catenin and NF-?B Signaling Pathways. Biochim Biophys Acta Mol Cell Res. 2017;1864:151-168 pubmed publisher
    ..Activated MMP-9/-2 and uPA/uPAR as well as suppressed TIMP-1/-2 and PAI-1 expressions by lucidone may promote the migration/invasion of keratinocytes...
  43. Gupta K, Donahue D, Sandoval Cooper M, Castellino F, Ploplis V. Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation. Sci Rep. 2017;7:365 pubmed publisher
    Plasminogen activator inhibitor-1 (PAI-1) is known to protect mice against cardiac fibrosis...
  44. Szaflarski J, Aurora K, Rawal P, Szaflarski M, Allendorfer J, DeWolfe J, et al. Personalities of patients with nonepileptic psychogenic status. Epilepsy Behav. 2015;52:143-8 pubmed publisher
    ..with typical intermittent psychogenic nonepileptic seizures (iPNES) using the Personality Assessment Inventory (PAI) and to compare their PAI profiles with the population norms...
  45. Ortiz Princz D, Daoud G, Salgado Sabel A, Cavazza M. Helicobacter pylori infection in children: should it be carefully assessed?. Eur Rev Med Pharmacol Sci. 2016;20:1798-813 pubmed
    ..include adhesins (BabA, SabA), vacuolating cytotoxin VacA, and the products of the cag pathogenicity island (cag PAI). There are geographic differences between cagA, vacA status and H. pylori related diseases...
  46. Nilsson A, Johansson Boll E, Sandberg J, Björck I. Gut microbiota mediated benefits of barley kernel products on metabolism, gut hormones, and inflammatory markers as affected by co-ingestion of commercially available probiotics: a randomized controlled study in healthy subjects. Clin Nutr ESPEN. 2016;15:49-56 pubmed publisher
    ..of markers of glucose metabolism (blood glucose, serum (s-) insulin), inflammation (s-IL-6, s-IL-18, s-CRP, PAI-1), and concentrations of gut derived hormones involved in satiety and glucose homeostasis (plasma (p-) PYY, p-GLP-..
  47. Zhu C, Shen H, Zhu L, Zhao F, Shu Y. Plasminogen Activator Inhibitor 1 Promotes Immunosuppression in Human Non-Small Cell Lung Cancers by Enhancing TGF-Î’1 Expression in Macrophage. Cell Physiol Biochem. 2017;44:2201-2211 pubmed publisher
    Plasminogen activator inhibitor-1 (PAI-1) has been regarded as a risk factor for thrombosis and atherosclerosis...
  48. Bartuski A, Kamachi Y, Schick C, Overhauser J, Silverman G. Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3. Genomics. 1997;43:321-8 pubmed
    ..Recently, we mapped four members of the family [SCCA1, SCCA2, PAI2, and PI5 (maspin)] to a 300-kb region within 18q21.3. Using a panel of 18q21...
  49. Massaro Giordano M, Marshall C, Lavker R, Jensen P, Risse Marsh B. Plasminogen activator inhibitor type 2 (PAI-2) is present in normal human conjunctiva. J Cell Physiol. 2005;205:295-301 pubmed
    The purpose was to characterize plasminogen activator inhibitor type 2 (PAI-2) expression in normal human conjunctiva in vivo and in vitro...
  50. Eftedal I, Fredriksen H, Hjelde A, Møllerløkken A. Evaluating PAI-1 as a biomarker for stress in diving: human serum total PAI-1 is unaltered after 2 h dry exposures to 280 kPa hyperbaric air. Physiol Rep. 2015;3: pubmed publisher
    Plasminogen activator inhibitor (PAI-1) is induced in the vasculature and secreted into the vascular lumen in response to inflammation and oxidative stress...
  51. Jung E, Kim J, Kim C, Kim S, Cho M. Gemigliptin, a dipeptidyl peptidase-4 inhibitor, inhibits retinal pericyte injury in db/db mice and retinal neovascularization in mice with ischemic retinopathy. Biochim Biophys Acta. 2015;1852:2618-29 pubmed publisher
    ..Gemigliptin attenuated the overexpression of plasminogen activator inhibitor-1 (PAI-1) in the retinas of diabetic and OIR mice...
  52. Khan S, Zhang D, Zhang Y, Li M, Wang C. Wogonin attenuates diabetic cardiomyopathy through its anti-inflammatory and anti-oxidative properties. Mol Cell Endocrinol. 2016;428:101-8 pubmed publisher
    ..ROS and MDA production, suppressed expression of inflammation factors such as IL-1β, IL-6, TNFα, and PAI-1, and inhibited NF-κB signaling...
  53. Lin Y, Chiu I, Cheng F, Lee Y, Wang Y, Hsu Y, et al. The role of hypoxia-inducible factor-1? in zinc oxide nanoparticle-induced nephrotoxicity in vitro and in vivo. Part Fibre Toxicol. 2016;13:52 pubmed
    ..Additionally, connective tissue growth factor (CTGF) and plasminogen activator inhibitor-1 (PAI-1), which are directly regulated by HIF-1 and are involved in the pathogenesis of kidney diseases, displayed ..
  54. Chen Y, Zheng Y, Liu L, Lin C, Liao C, Xin L, et al. Adiponectin Inhibits TNF-?-Activated PAI-1 Expression Via the cAMP-PKA-AMPK-NF-?B Axis in Human Umbilical Vein Endothelial Cells. Cell Physiol Biochem. 2017;42:2342-2352 pubmed publisher
    Tumor necrosis factor (TNF)-? can upregulate the expression of plasminogen activator inhibitor (PAI)-1, an inhibitor of fibrinolysis. Adiponectin (Adp) antagonizes TNF-? by negatively regulating its expression in various tissues...
  55. Kruithof E, Cousin E. Plasminogen activator inhibitor 2. Isolation and characterization of the promoter region of the gene. Biochem Biophys Res Commun. 1988;156:383-8 pubmed
    We have isolated the promoter region and part of the coding region of the human plasminogen activator inhibitor 2 gene. The first two exons (65 and 177 base pairs, respectively) are separated by a 3.6 kilo base pair intron...
  56. El Edel R, Essa E, Essa A, Hegazy S, El Rowedy D. Serum PAI-1 and PAI-1 4G/5G Polymorphism in Hepatitis C Virus-Induced Cirrhosis and Hepatitis C Virus-Induced Hepatocellular Carcinoma Patients. Viral Immunol. 2016;29:510-515 pubmed
    Association between variable agent-induced hepatocellular carcinoma (HCC) and both PAI-1 4G/5G polymorphism and plasminogen activator inhibitor (PAI-1) levels compared to healthy controls have been reported in earlier studies...
  57. Ni Y, Kannadorai R, Peng J, Yu S, Chang Y, Wu J. Naphthalene-fused BODIPY near-infrared dye as a stable contrast agent for in vivo photoacoustic imaging. Chem Commun (Camb). 2016;52:11504-11507 pubmed
    Photoacoustic imaging (PAI) has emerged as an advantageous modality with high resolution and deep tissue penetration. However, its application is limited by the lack of available contrast agents...
  58. Wu J, Lan F, Lu Y, He Q, Li B. Molecular Characteristics of ST1193 Clone among Phylogenetic Group B2 Non-ST131 Fluoroquinolone-Resistant Escherichia coli. Front Microbiol. 2017;8:2294 pubmed publisher
    ..2%), kpsMT II (group II capsule, 90.2%), kpsK1 (K1 capsule, 86.3%) and PAI. Conclusion: ST1193 lineage accounts for the majority of group B2-FQr-non-ST131 E...
  59. Samia J, Alexander S, Horton K, Auron P, Byers M, Shows T, et al. Chromosomal organization and localization of the human urokinase inhibitor gene: perfect structural conservation with ovalbumin. Genomics. 1990;6:159-67 pubmed
    b>Plasminogen activator inhibitor 2 (PAI-2) plays an essential role in the regulation of localized extracellular proteolysis by its inactivation of urokinase...
  60. Razik E, Kobierzycki C, Grzegrzolka J, Podhorska Okolow M, Drag Zalesinska M, Zabel M, et al. Plasminogen Activation System in Rectal Adenocarcinoma. Anticancer Res. 2015;35:6009-15 pubmed
    ..e. urokinase plasminogen activator (uPA), receptor of uPA (uPAR), plasminogen activating inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) in the primary site of rectal adenocarcinoma, as well as in lymph node ..
  61. Montazer Torbati F, Boutinaud M, Brun N, Richard C, Neveu A, Jaffrezic F, et al. Differences during the first lactation between cows cloned by somatic cell nuclear transfer and noncloned cows. J Dairy Sci. 2016;99:4778-4794 pubmed publisher
    ..is triggered by insulin-like factor growth binding protein 5 (IGFBP5) and plasminogen activator inhibitor (PAI), which both interact with CSN1S2...
  62. Obi A, Andraska E, Kanthi Y, Kessinger C, Elfline M, Luke C, et al. Endotoxaemia-augmented murine venous thrombosis is dependent on TLR-4 and ICAM-1, and potentiated by neutropenia. Thromb Haemost. 2017;117:339-348 pubmed publisher
    ..Paradoxically, VT formed without PMNs was amplified, potentially related to endotoxaemia induced elevation of PAI-1 and circulating FXIII, and decreased uPA...
  63. Persico G, Antolini L, Vergani P, Costantini W, Nardi M, Bellotti L. Maternal singing of lullabies during pregnancy and after birth: Effects on mother-infant bonding and on newborns' behaviour. Concurrent Cohort Study. Women Birth. 2017;30:e214-e220 pubmed publisher
    ..a. and followed up to 3 months after birth. The Prenatal Attachment Inventory (PAI) and the Mother-to-Infant Bonding Scale (MIBS) were used to assess maternal-foetal attachment and postnatal bonding...
  64. Chen X, Jiang Y, Pan D. miR-30c may serve a role in endometriosis by targeting plasminogen activator inhibitor-1. Exp Ther Med. 2017;14:4846-4852 pubmed publisher
    ..The expression of miR-30c and plasminogen activator inhibitor type 1 (PAI-1) mRNA in EMs tissues was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and ..
  65. Hammond C, Beeson C, Suarez G, Peek R, Backert S, Smolka A. Helicobacter pylori virulence factors affecting gastric proton pump expression and acid secretion. Am J Physiol Gastrointest Liver Physiol. 2015;309:G193-201 pubmed publisher
    ..pylori colonization. Infection by H. pylori strains deficient in the cag pathogenicity island (cag PAI) genes cagL, cagE, or cagM, which do not transfer CagA into host cells or induce interleukin-8 secretion, does not ..
  66. Hedbrant A, Wijkander J, Seidal T, Delbro D, Erlandsson A. Macrophages of M1 phenotype have properties that influence lung cancer cell progression. Tumour Biol. 2015;36:8715-25 pubmed publisher
    ..such as urokinase-type plasminogen activator (uPA), its receptor uPAR, and plasminogen activator inhibitor-1 (PAI-1), but knowledge of how essential their contribution is in comparison to the cancer cells in small cell lung ..
  67. Dupont D, Larsen N, Jensen J, Andreasen P, Kjems J. Characterisation of aptamer-target interactions by branched selection and high-throughput sequencing of SELEX pools. Nucleic Acids Res. 2015;43:e139 pubmed publisher
    ..2'-fluoropyrimidine-modified RNA enriched for aptamers specific for the serpin plasminogen activator inhibitor-1 (PAI-1) through five rounds of standard selection...
  68. Atta H, Al Hendy A, Abdel Raheim S, Abdel Ghany H, Nasif K, Abdellah A, et al. Modified Adenovirus Reduces De Novo Peritoneal Adhesions in Rats and Limits Off-Target Transfection. Role of EZH2 in Adhesion Formation. J Invest Surg. 2017;30:78-87 pubmed publisher
    ..Levels of tPA, plasminogen activator inhibitor-1 (PAI-1), transforming growth factor-?1 (TGF-?1), and EZH2 expression were measured...
  69. Burleson A, Guler N, Banos A, Syed D, Wanderling C, Hoppensteadt D, et al. Perioperative Factors and Their Effect on the Fibrinolytic System in Arthroplasty Patients. Clin Appl Thromb Hemost. 2016;22:274-9 pubmed publisher
    ..Antigenic levels of d-dimer, plasminogen activator inhibitor 1 (PAI-1), and tissue plasminogen activator (tPA) were measured using a commercially available enzyme-linked immunosorbent ..
  70. Williams M, Cushman M, Ouyang P, Heckbert S, Kalyani R, Vaidya D. Association of Serum Sex Hormones with Hemostatic Factors in Women On and Off Hormone Therapy: The Multiethnic Study of Atherosclerosis. J Womens Health (Larchmt). 2016;25:166-72 pubmed publisher
    ..A smaller random sample of 491 women also had von Willebrand factor (vWF), plasminogen activator inhibitor (PAI-1), and tissue factor pathway inhibitor (TFPI) levels measured...
  71. Bucci J, Trelle M, McClintock C, Qureshi T, Jørgensen T, Peterson C. Copper(II) Ions Increase Plasminogen Activator Inhibitor Type 1 Dynamics in Key Structural Regions That Govern Stability. Biochemistry. 2016;55:4386-98 pubmed publisher
    Plasminogen activator inhibitor type 1 (PAI-1) regulates the fibrinolysis pathway by inhibiting the protease activity of plasminogen activators...
  72. Agirbasli M, Göktay F, Peker I, Gunes P, Aker F, Akkiprik M. Enhanced mRNA expression of plasminogen activator inhibitor-1 in livedoid vasculopathy lesions. Cardiovasc Ther. 2017;35: pubmed publisher
    ..Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of fibrinolysis and is a pivotal modulator in a broad range of biological ..
  73. Rathouska J, Fikrová P, Mrkvicova A, Blazickova K, Varejckova M, Dolezelova E, et al. High soluble endoglin levels do not induce changes in structural parameters of mouse heart. Heart Vessels. 2017;32:1013-1024 pubmed publisher
    ..affect the expression of selected members of TGF-β signaling (membrane endoglin, TGFβRII, ALK-5, ALK-1, Id-1, PAI-1 and activated Smad proteins-pSmad 1,5 and pSmad 2,3), inflammation, heart remodeling (PDGFb, Col1A1) and ..
  74. Kes V, Jurasic M, Zavoreo I, Corić L, Rotim K. MIGRAINE, CAROTID STIFFNESS AND GENETIC POLYMORPHISM. Acta Clin Croat. 2015;54:409-16 pubmed
    ..patients with migraine had greater incidence of homozygous mutations for procoagulant genes (MTHFR (C677T), PAI-1 and ACE I/D) than expected...
  75. Gautam P, Karhinen L, Szwajda A, Jha S, Yadav B, Aittokallio T, et al. Identification of selective cytotoxic and synthetic lethal drug responses in triple negative breast cancer cells. Mol Cancer. 2016;15:34 pubmed publisher
    ..For example, PAI-1, MAPK phosphatase and Notch-3 levels associated with cytotoxic responses to mitotic and proteasome inhibitors, ..
  76. Zhao R, Le K, Moghadasian M, Shen G. Reduced monocyte adhesion to aortae of diabetic plasminogen activator inhibitor-1 knockout mice. Inflamm Res. 2017;66:783-792 pubmed publisher
    To determine the requirement of plasminogen activator inhibitor-1-knockout (PAI-1) for monocyte adhesion in animals and cells under diabetic conditions...
  77. Park C, Kwon S, Hong H, Kang S, Jeon I, Park S, et al. Development and preclinical trials of a wire-driven end effector device for frozen shoulder treatment. Med Biol Eng Comput. 2018;56:1149-1160 pubmed publisher
    ..The end effector is made of an elastic material called PAI (polyamide-imide) with its outer diameter and total length being 4 and 19 mm...
  78. Williams D, Risse B, Kim S, Saunders D, Orlin S, Baker M, et al. Plasminogen activator inhibitor type 2 in human corneal epithelium. Invest Ophthalmol Vis Sci. 1999;40:1669-75 pubmed
    ..corneal epithelium in vivo and in vitro for expression and status of plasniinogcn activ:ltor inhibitor type 2 (PAI-2). Normal hiuman corneas were prepared for frozen sections and for culture of corneal keratinocytes...
  79. Davidson I, Beathard G, Gallieni M, Ross J. The DRIL procedure for arteriovenous access ischemic steal: a controversial approach. J Vasc Access. 2017;18:1-2 pubmed publisher
    ..from the original anastomosis, makes this modification similar to the less invasive proximal arterial inflow (PAI) procedure...
  80. Plumb A, Huynh N, Guggenheim J, Zhang E, Beard P. Rapid volumetric photoacoustic tomographic imaging with a Fabry-Perot ultrasound sensor depicts peripheral arteries and microvascular vasomotor responses to thermal stimuli. Eur Radiol. 2018;28:1037-1045 pubmed publisher
    To determine if a new photoacoustic imaging (PAI) system successfully depicts (1) peripheral arteries and (2) microvascular circulatory changes in response to thermal stimuli...
  81. Syrjanen S, Naud P, Sarian L, Derchain S, Roteli Martins C, Longatto Filho A, et al. Up-regulation of plasminogen activator inhibitor-2 is associated with high-risk HPV and grade of cervical lesion at baseline but does not predict outcomes of high-risk HPV infections or incident CIN. Am J Clin Pathol. 2009;132:883-92 pubmed publisher
    Protease inhibitor serpin-B2 (plasminogen activator inhibitor-2 [PAI-2]) protects pRb from degradation in human papillomavirus (HPV)-18+ HeLa cells...
  82. Tanaka S, Nagashima H, Cruz M, Uchida T, Uotani T, Jiménez Abreu J, et al. Interleukin-17C in Human Helicobacter pylori Gastritis. Infect Immun. 2017;85: pubmed publisher
    ..infections compared to cells infected with either cagA-negative or cag pathogenicity island (PAI) mutant...
  83. Abd El Motteleb D, Ibrahim I, Elshazly S. Sildenafil protects against bile duct ligation induced hepatic fibrosis in rats: Potential role for silent information regulator 1 (SIRT1). Toxicol Appl Pharmacol. 2017;335:64-71 pubmed publisher
    ..marked reductions of transforming growth factor (TGF)-? content, expression of plasminogen activator inhibitor-1 (PAI-1), matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), ?-smooth muscle actin (?-..
  84. Ohtani Kaneko R, Sato K, Tsutiya A, Nakagawa Y, Hashizume K, Tazawa H. Characterisation of human induced pluripotent stem cell-derived endothelial cells under shear stress using an easy-to-use microfluidic cell culture system. Biomed Microdevices. 2017;19:91 pubmed publisher
    ..smooth muscle marker gene smooth muscle alpha-actin, and investigated changes in plasminogen activator inhibitor-1 (PAI-1) secretion and intracellular F-actin arrangement following heat stress...
  85. Korybalska K, Luczak J, Swora Cwynar E, Kanikowska A, Czepulis N, Kanikowska D, et al. Weight loss-dependent and -independent effects of moderate calorie restriction on endothelial cell markers in obesity. J Physiol Pharmacol. 2017;68:597-608 pubmed
    ..intervention did not correct adiponectin, antioxidant status, vWF, TM, and plasminogen activator inhibitor-1 (PAI-1) but ameliorated changes in other parameters...
  86. Zhang R, Cheng K, Antaris A, Ma X, Yang M, Ramakrishnan S, et al. Hybrid anisotropic nanostructures for dual-modal cancer imaging and image-guided chemo-thermo therapies. Biomaterials. 2016;103:265-277 pubmed publisher
    ..capability [chemotherapy, photothermal therapy, magnetic resonance imaging (MRI), and photoacoustic imaging (PAI)]...
  87. Massei G, Coats J, Lambert M, Pietravalle S, Gill R, Cowan D. Camera traps and activity signs to estimate wild boar density and derive abundance indices. Pest Manag Sci. 2017;: pubmed publisher
    ..For each woodland, we calculated a Passive Activity Index (PAI) based on camera trap surveys, rooting activity and wild boar trails on transects and estimated absolute densities ..
  88. Giofrè M, Napoli F, La Rosa D, Caruso A, Laganà N, Orlando Settembrini L, et al. Recurrent Thrombosis: A Case of Hereditary Thromboembolism. Am J Case Rep. 2017;18:1157-1159 pubmed
    ..thrombosis and pulmonary embolism have been identified in recent studies, including 4G/4G polymorphism of the PAI-1 gene...
  89. Zhu Y, Li H, Wang X. Lunasin abrogates monocytes to endothelial cells. Mol Immunol. 2017;92:146-150 pubmed publisher
    ..In addition, lunasin treatment could reverse the effects of ox-LDL on the expression of eNOS and PAI-1, the direct target genes of KLF2...
  90. Nishida Y, Hayashi Y, Imai Y, Itoh H. Expression and localization of the urokinase-type plasminogen activator receptor (uPAR) in the human placenta. Kobe J Med Sci. 1998;44:31-43 pubmed
    ..The placenta is a source of both plasminogen activator inhibitor type 2 (PAI-2) and type 1 (PAI-1)...
  91. Cufer T, Vrhovec I, Borstnar S. Prognostic significance of plasminogen activator inhibitor-1 in breast cancer, with special emphasis on locoregional recurrence-free survival. Int J Biol Markers. 2002;17:33-41 pubmed
    The independent prognostic value of protease uPA and its inhibitor PAI-1 for survival in breast cancer patients is firmly established...
  92. Gettins P, Olson S. Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance. Biochem J. 2016;473:2273-93 pubmed publisher
    ..Finally, since binding of serpins and their proteinase complexes, particularly plasminogen activator inhibitor-1 (PAI-1), to the clearance and signalling receptor LRP1 (low density lipoprotein receptor-related protein 1), may affect ..