SERPINA12

Summary

Gene Symbol: SERPINA12
Description: serpin family A member 12
Alias: OL-64, serpin A12, serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12, vaspin, visceral adipose tissue-derived serine protease inhibitor, visceral adipose-specific SERPIN
Species: human
Products:     SERPINA12

Top Publications

  1. Ye Y, Hou X, Pan X, Lu J, Jia W. Serum vaspin level in relation to postprandial plasma glucose concentration in subjects with diabetes. Chin Med J (Engl). 2009;122:2530-3 pubmed
    b>Vaspin is a newly-identified adipocytokine related to obesity and insulin sensitivity. However, its pathophysiologic role in humans remains largely unknown...
  2. Choi S, Kwak S, Lee Y, Moon M, Lim S, Park Y, et al. Plasma vaspin concentrations are elevated in metabolic syndrome in men and are correlated with coronary atherosclerosis in women. Clin Endocrinol (Oxf). 2011;75:628-35 pubmed publisher
    b>Vaspin is visceral adipose-tissue-derived adipokine, which has an insulin-sensitizing effect in obese type 2 diabetic rodent models...
  3. Heiker J, Kloting N, Kovacs P, Kuettner E, Strater N, Schultz S, et al. Vaspin inhibits kallikrein 7 by serpin mechanism. Cell Mol Life Sci. 2013;70:2569-83 pubmed publisher
    The molecular target of the adipokine vaspin (visceral adipose tissue-derived serpin; serpinA12) and its mode of action are unknown...
  4. Cho J, Han T, Kang H. Combined effects of body mass index and cardio/respiratory fitness on serum vaspin concentrations in Korean young men. Eur J Appl Physiol. 2010;108:347-53 pubmed publisher
    ..information is available regarding how body fatness and cardio/respiratory fitness (CRF) are associated with serum vaspin. The purpose of the study was to investigate the combined effect of body mass index (BMI) and CRF on serum vaspin ..
  5. Youn B, Kloting N, Kratzsch J, Lee N, Park J, Song E, et al. Serum vaspin concentrations in human obesity and type 2 diabetes. Diabetes. 2008;57:372-7 pubmed
    b>Vaspin was identified as an adipokine with insulin-sensitizing effects, which is predominantly secreted from visceral adipose tissue in a rat model of type 2 diabetes...
  6. Suleymanoglu S, Tascilar E, Pirgon O, Tapan S, Meral C, Abaci A. Vaspin and its correlation with insulin sensitivity indices in obese children. Diabetes Res Clin Pract. 2009;84:325-8 pubmed publisher
    The aim of this study was to assess the vaspin and adiponectin concentrations on markers of insulin sensitivity and obesity in pubertal obese children and adolescents...
  7. Jeong E, Youn B, Kim D, Kim E, Park J, Namkoong C, et al. Circadian rhythm of serum vaspin in healthy male volunteers: relation to meals. J Clin Endocrinol Metab. 2010;95:1869-75 pubmed publisher
    Visceral adipose tissue-derived serine protease inhibitor (vaspin) is a novel adipokine with insulin-sensitizing effects. However, the physiological role for vaspin in human metabolic regulation remains to be established...
  8. El Mesallamy H, Kassem D, El Demerdash E, Amin A. Vaspin and visfatin/Nampt are interesting interrelated adipokines playing a role in the pathogenesis of type 2 diabetes mellitus. Metabolism. 2011;60:63-70 pubmed publisher
    Recently, vaspin and visfatin/Nampt have been identified as interesting novel adipokines having insulin-sensitizing and insulin-mimetic effects, respectively...
  9. Oberbach A, Kirsch K, Lehmann S, Schlichting N, Fasshauer M, Zarse K, et al. Serum vaspin concentrations are decreased after exercise-induced oxidative stress. Obes Facts. 2010;3:328-31 pubmed publisher
    Elevated visceral adipose tissue-derived serpin (vaspin) serum concentrations are associated with impaired insulin sensitivity, but increase unexpectedly after long-term physical training...

More Information

Publications102 found, 100 shown here

  1. Lee J, Park H, Song Y, Jang Y, Kim J, Lee Y, et al. Relationship between vaspin gene expression and abdominal fat distribution of Korean women. Endocr J. 2011;58:639-46 pubmed
    Visceral adipose tissue-derived serpin (vaspin) is a novel adipokine that is thought to have insulin-sensitizing effects...
  2. Kim J, Kim T, Won J. Association between serum vaspin level and metabolic syndrome in healthy Korean subjects. Metab Syndr Relat Disord. 2013;11:385-91 pubmed publisher
    Visceral obesity is associated with insulin resistance, diabetes, and cardiovascular diseases. Vaspin [visceral adipose tissue (VAT)-derived serpin] may be a novel adipokine related to obesity and its metabolic consequences...
  3. von Loeffelholz C, Mohlig M, Arafat A, Isken F, Spranger J, Mai K, et al. Circulating vaspin is unrelated to insulin sensitivity in a cohort of nondiabetic humans. Eur J Endocrinol. 2010;162:507-13 pubmed publisher
    To study the association of vaspin with glucose metabolism. Cross-sectional and intervention study. The association of serum vaspin with metabolic and anthropometric characteristics was investigated in 108 volunteers...
  4. Lee M, Jekal Y, Im J, Kim E, Lee S, Park J, et al. Reduced serum vaspin concentrations in obese children following short-term intensive lifestyle modification. Clin Chim Acta. 2010;411:381-5 pubmed publisher
    Recently, visceral adipose tissue-derived serpin (vaspin) was identified as a potential insulin sensitizing adipokine, however, the factors determining the levels of circulating vaspin levels have not been fully understood...
  5. Çınar N, Gulcelik N, Aydin K, Akín S, Usman A, Gurlek A. Serum vaspin levels in hypothyroid patients. Eur J Endocrinol. 2011;165:563-9 pubmed publisher
    ..Animal studies demonstrated a possible relationship between vaspin levels and thyroid functions...
  6. Tan B, Heutling D, Chen J, Farhatullah S, Adya R, Keay S, et al. Metformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance. Diabetes. 2008;57:1501-7 pubmed publisher
    Polycystic ovary syndrome (PCOS) is associated with insulin resistance and obesity. Vaspin (visceral adipose tissue-derived serine protease inhibitor) levels increase with hyperinsulinemia and obesity...
  7. Kempf K, Rose B, Illig T, Rathmann W, Strassburger K, Thorand B, et al. Vaspin (SERPINA12) genotypes and risk of type 2 diabetes: Results from the MONICA/KORA studies. Exp Clin Endocrinol Diabetes. 2010;118:184-9 pubmed publisher
    b>Vaspin has recently been identified as novel adipokine with high expression in adipose tissue of obese and type 2 diabetic subjects and with potentially insulin-sensitising properties...
  8. Aust G, Richter O, Rohm S, Kerner C, Hauss J, Kloting N, et al. Vaspin serum concentrations in patients with carotid stenosis. Atherosclerosis. 2009;204:262-6 pubmed publisher
    ..Recently, visceral adipose tissue-derived serpin (vaspin) was identified as a novel adipokine related to obesity and its metabolic consequences...
  9. Chang H, Park H, Park C, Song Y, Jang Y. Association between serum vaspin concentrations and visceral adipose tissue in Korean subjects. Metabolism. 2010;59:1276-81 pubmed publisher
    ..Visceral adipose tissue (VAT)-derived serpin (vaspin) is a novel adipokine with potential insulin-sensitizing effects...
  10. Teshigawara S, Wada J, Hida K, Nakatsuka A, Eguchi J, Murakami K, et al. Serum vaspin concentrations are closely related to insulin resistance, and rs77060950 at SERPINA12 genetically defines distinct group with higher serum levels in Japanese population. J Clin Endocrinol Metab. 2012;97:E1202-7 pubmed publisher
    ..Single nucleotide polymorphisms (SNP) at SERPINA12 (vaspin) gene locus were discovered, and five SNP were genotyped in the subjects with varied body mass index (n =..
  11. Nakatsuka A, Wada J, Iseda I, Teshigawara S, Higashio K, Murakami K, et al. Visceral adipose tissue-derived serine proteinase inhibitor inhibits apoptosis of endothelial cells as a ligand for the cell-surface GRP78/voltage-dependent anion channel complex. Circ Res. 2013;112:771-80 pubmed publisher
    Visceral adipose tissue-derived serine proteinase inhibitor (vaspin) is an adipokine identified from visceral adipose tissues of genetically obese rats...
  12. Hida K, Wada J, Eguchi J, Zhang H, Baba M, Seida A, et al. Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci U S A. 2005;102:10610-5 pubmed
    ..We identified an adipocytokine, designated as visceral adipose tissue-derived serpin (vaspin), which is a member of serine protease inhibitor family...
  13. Kloting N, Berndt J, Kralisch S, Kovacs P, Fasshauer M, Schön M, et al. Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes. Biochem Biophys Res Commun. 2006;339:430-6 pubmed
    Recently, vaspin was identified as an adipokine with insulin-sensitizing effects, which is predominantly secreted from visceral adipose tissue in a rat model of type 2 diabetes...
  14. Kukla M, Mazur W, Bułdak R, Zwirska Korczala K. Potential role of leptin, adiponectin and three novel adipokines--visfatin, chemerin and vaspin--in chronic hepatitis. Mol Med. 2011;17:1397-410 pubmed publisher
    ..b>Vaspin expression in human adipose tissue seems to be a compensatory mechanism associated with obesity and insulin ..
  15. Breitfeld J, Tonjes A, Bottcher Y, Schleinitz D, Wiele N, Marzi C, et al. Genetic variation in the vaspin gene affects circulating serum vaspin concentrations. Int J Obes (Lond). 2013;37:861-6 pubmed publisher
    Visceral adipose tissue-derived serine protease inhibitor (vaspin) is an adipokine potentially linking obesity, insulin resistance and type 2 diabetes...
  16. Kadoglou N, Gkontopoulos A, Kapelouzou A, Fotiadis G, Theofilogiannakos E, Kottas G, et al. Serum levels of vaspin and visfatin in patients with coronary artery disease-Kozani study. Clin Chim Acta. 2011;412:48-52 pubmed publisher
    The association of novel adipokines, vaspin and visfatin, with atherosclerosis is still obscure...
  17. Saalbach A, Vester K, Rall K, Tremel J, Anderegg U, Beck Sickinger A, et al. Vaspin--a link of obesity and psoriasis?. Exp Dermatol. 2012;21:309-12 pubmed publisher
    Psoriasis is an inflammatory skin disease often associated with obesity. The anti-inflammatory adipokine vaspin, a suggested serine proteinase inhibitor of the serpin family, is discussed as a new link between inflammation and obesity...
  18. Wang C, Yen J, Cheng Y, Lin C, Hsieh C, Gau R, et al. Polygala tenuifolia extract inhibits lipid accumulation in 3T3-L1 adipocytes and high-fat diet-induced obese mouse model and affects hepatic transcriptome and gut microbiota profiles. Food Nutr Res. 2017;61:1379861 pubmed publisher
    ..tenuifolia extract; Saa1: serum amyloid A1; SD: standard deviation; SEM: standard error of the mean; Serpina12: serpin family member 12; Sqle: squalene monooxygenase; SREBP1C: sterol regulatory element-binding protein 1C; ..
  19. Li Y, Li C, Qi J, Huang L, Shi D, Du S, et al. Relationships of Dietary Histidine and Obesity in Northern Chinese Adults, an Internet-Based Cross-Sectional Study. Nutrients. 2016;8: pubmed publisher
    ..factor-? (TNF-?), interleukin-1? (IL-1?), interleukin-6 (IL-6), C-reactive protein (CRP), malonaldehyde (MDA) and vaspin and higher glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and adiponectin of overweight/obese ..
  20. Jaganathan R, Ravindran R, Dhanasekaran S. Emerging Role of Adipocytokines in Type 2 Diabetes as Mediators of Insulin Resistance and Cardiovascular Disease. Can J Diabetes. 2018;42:446-456.e1 pubmed publisher
    ..Adiponectin plays a key role as an anti-inflammatory hormone. Upregulated expression of resistin, vaspin, apelin and TNF-α plays a significant role in induction of insulin resistance linked with obesity and type 2 ..
  21. Ma L, Wang R, Dong W, Zhao Z. Caloric restriction can improve learning and memory in C57/BL mice probably via regulation of the AMPK signaling pathway. Exp Gerontol. 2018;102:28-35 pubmed publisher
    ..CR increased serum insulin-like growth factor, adiponectin and vaspin, decreased blood glucose and serum malondialdehyde, and improved insulin sensitivity...
  22. Derosa G, Romano D, Tinelli C, D Angelo A, Maffioli P. Prevalence and associations of erectile dysfunction in a sample of Italian males with type 2 diabetes. Diabetes Res Clin Pract. 2015;108:329-35 pubmed publisher
    ..lipid profile, sexual hormones, adiponectin (ADN), resistin, retinol binding protein-4 (RBP-4), visfatin, vaspin. 52.9% of patients were affected by ED...
  23. Sawicka M, Janowska J, Chudek J. Potential beneficial effect of some adipokines positively correlated with the adipose tissue content on the cardiovascular system. Int J Cardiol. 2016;222:581-589 pubmed publisher
    ..tumour necrosis factor-)α, CTRP-3 (C1q/tumour necrosis factor (TNF) related protein), leptin, visfatin and vaspin. This activity is associated with the promotion of regeneration processes in the damaged myocardium, formation of ..
  24. Bao W, Baecker A, Song Y, Kiely M, Liu S, Zhang C. Adipokine levels during the first or early second trimester of pregnancy and subsequent risk of gestational diabetes mellitus: A systematic review. Metabolism. 2015;64:756-64 pubmed publisher
    ..retinol binding protein (RBP-4), resistin, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and vaspin. We did not identify prospective studies for several novel adipokines, including chemerin, apelin, omentin, or ..
  25. Reinehr T, Roth C. Inflammation Markers in Type 2 Diabetes and the Metabolic Syndrome in the Pediatric Population. Curr Diab Rep. 2018;18:131 pubmed publisher
    ..factor-alpha (TNF-α), interleukin (IL)-6, IL-1β, interferon gamma, pigment epithelium-derived factor, chemerin, vaspin, and fetuin A...
  26. Zarzour R, Alshawsh M, Asif M, Al Mansoub M, Mohamed Z, Ahmad M, et al. Adipocytokine Regulation and Antiangiogenic Activity Underlie the Molecular Mechanisms of Therapeutic Effects of Phyllanthus niruri against Non-Alcoholic Fatty Liver Disease. Nutrients. 2018;10: pubmed publisher
    ..rats, were associated with a significant increase in serum adiponectin, reduction in the serum levels of RBP4, vaspin, progranulin, TNF-α, IL-6, and significant downregulation of the hepatic gene expression of PPARγ, SLC10A2, and ..
  27. Shihabudeen M, Roy D, James J, Thirumurugan K. Chenodeoxycholic acid, an endogenous FXR ligand alters adipokines and reverses insulin resistance. Mol Cell Endocrinol. 2015;414:19-28 pubmed publisher
    ..several of the tested pro-inflammatory adipokines (TNF-α, MCP-1, IL-6, Chemerin, PAI, RBP4, resistin, vaspin), and enhanced the major anti-inflammatory and insulin sensitizing adipokines (adiponectin, leptin)...
  28. Polak K, Czyzyk A, Simoncini T, Meczekalski B. New markers of insulin resistance in polycystic ovary syndrome. J Endocrinol Invest. 2017;40:1-8 pubmed publisher
    ..are strongly involved with PCOS physiopathology and IR, such as some adipocytokines (adiponectin, visfatin, vaspin and apelin), copeptin, irisin, PAI-1 and zonulin...
  29. Fasshauer M, Blüher M. Adipokines in health and disease. Trends Pharmacol Sci. 2015;36:461-70 pubmed publisher
    ..retinol-binding protein 4 (RBP4), dipeptidyl peptidase 4 (DPP-4), bone morphogenetic protein (BMP)-4, BMP-7, vaspin, apelin, and progranulin, is altered in adipose tissue dysfunction and may contribute to a spectrum of obesity-..
  30. Kim Y, Kim M, Kang J, Kim H, Park J, Lee J, et al. Transcriptome sequencing of gingival biopsies from chronic periodontitis patients reveals novel gene expression and splicing patterns. Hum Genomics. 2016;10:28 pubmed publisher
    ..The top 10 most down-regulated genes were SERPINA12, MT4, H19, KRT2, DSC1, PSORS1C2, KRT27, LCE3C, AQ5, and LCE6A...
  31. Inoue J, Wada J, Teshigawara S, Hida K, Nakatsuka A, Takatori Y, et al. The serum vaspin levels are reduced in Japanese chronic hemodialysis patients. BMC Nephrol. 2012;13:163 pubmed publisher
    Visceral adipose tissue-derived serine proteinase inhibitor (vaspin) is an adipokine identified in genetically obese rats that correlates with insulin resistance and obesity in humans...
  32. Cakal E, Ustun Y, Engin Ustun Y, Ozkaya M, Kilinc M. Serum vaspin and C-reactive protein levels in women with polycystic ovaries and polycystic ovary syndrome. Gynecol Endocrinol. 2011;27:491-5 pubmed publisher
    Our aim was to evaluate C-reactive protein (CRP) and serum vaspin levels in women with polycystic ovary syndrome (PCOS) or polycystic ovaries (PCO). Twenty-four women with PCOS and 23 women with PCO constituted the study groups...
  33. Zhang Q, Xu D, Zhang M, Dong X, Dong H, Pan Q. Construction and Analysis of an Adipose Tissue-Specific and Methylation-Sensitive Promoter of Leptin Gene. Appl Biochem Biotechnol. 2016;180:1213-1226 pubmed
    ..regions of five adipose tissue-specific transcriptional factors-Adiponectin, Chemerin, Leptin, Smaf-1, and Vaspin-and examined their messenger RNA (mRNA) expression levels in different mouse tissues...
  34. Astafev A, Patel S, Kondratov R. Calorie restriction effects on circadian rhythms in gene expression are sex dependent. Sci Rep. 2017;7:9716 pubmed publisher
    ..and the effects of CR were sex-specific for several genes previously reported to be regulated by CR: Fmo3, Mup4, Serpina12 and Cyp4a12, while the expression of Cyp4a14a was sex independent...
  35. Kim D, Burt A, Crosslin D, Robertson P, Ranchalis J, Boyko E, et al. Novel common and rare genetic determinants of paraoxonase activity: FTO, SERPINA12, and ITGAL. J Lipid Res. 2013;54:552-60 pubmed publisher
    ..Three novel genes (FTO, ITGAL, and SERPINA12) and the PON gene cluster had SNPs associated with PON1 arylesterase (AREase) activity...
  36. Esteghamati A, Mousavizadeh M, Noshad S, Zandieh A, Zarei H, Nakhjavani M. Gender-dependent effects of metformin on vaspin and adiponectin in type 2 diabetes patients: a randomized clinical trial. Horm Metab Res. 2013;45:319-25 pubmed publisher
    The aim of the study was to assess the effects of metformin on serum concentrations of vaspin and adiponectin in diabetes...
  37. Maijer K, Neumann E, Müller Ladner U, Drop D, Ramwadhdoebe T, Choi I, et al. Serum Vaspin Levels Are Associated with the Development of Clinically Manifest Arthritis in Autoantibody-Positive Individuals. PLoS ONE. 2015;10:e0144932 pubmed publisher
    ..Levels of adiponectin, vaspin, resistin, leptin, chemerin and omentin were determined in baseline fasting serum samples (n = 27)...
  38. Ulbricht D, Oertwig K, Arnsburg K, Saalbach A, Pippel J, Strater N, et al. Basic Residues of ?-Sheet A Contribute to Heparin Binding and Activation of Vaspin (Serpin A12). J Biol Chem. 2017;292:994-1004 pubmed publisher
    ..Visceral adipose tissue-derived serpin (vaspin), serpin A12 of the serpin family, and its target protease kallikrein 7 (KLK7) are heparin-binding proteins, and inhibition ..
  39. Wada J. [Vaspin and insulin resistance]. Rinsho Byori. 2008;56:705-11 pubmed
    We have identified the vaspin gene(serpina12), which is up-regulated in visceral white adipose tissues (WATs) of Otsuka Long-Evans Tokushima fatty (OLETF) rat, an animal model of abdominal obesity and type 2 diabetes...
  40. Zhu X, Jiang Y, Shan P, Shen J, Liang Q, Cui R, et al. Vaspin attenuates the apoptosis of human osteoblasts through ERK signaling pathway. Amino Acids. 2013;44:961-8 pubmed publisher
    ..b>Vaspin is a novel adipocytokine isolated from visceral white adipose tissue, which has been reported to have anti-..
  41. Cura H, Ozdemir H, Demir C, Bulut S, Ilhan N, Inci M. Investigation of vaspin level in patients with acute ischemic stroke. J Stroke Cerebrovasc Dis. 2014;23:453-6 pubmed publisher
    ..Visceral adipose tissue-derived serpin (vaspin) is a new adipokine, which is identified recently, associated with obesity and diabetes and also has a ..
  42. Saalbach A, Tremel J, Herbert D, Schwede K, Wandel E, Schirmer C, et al. Anti-Inflammatory Action of Keratinocyte-Derived Vaspin: Relevance for the Pathogenesis of Psoriasis. Am J Pathol. 2016;186:639-51 pubmed publisher
    ..We have previously identified KCs as a rich source of the serpin protease inhibitor vaspin (serpinA12), originally described as an adipokine in adipose tissue...
  43. Yang W, Li Y, Tian T, Wang L, Lee P, Hua Q. Serum vaspin concentration in elderly patients with type 2 diabetes mellitus and macrovascular complications. BMC Endocr Disord. 2017;17:67 pubmed publisher
    ..b>Vaspin is a novel adipocyte with insulin sensitizing effects...
  44. Kukla M, Waluga M, Sawczyn T, Berdowska A, Kajor M, Boryczka G, et al. Serum vaspin may be a good indicator of fibrosis in chronic hepatitis C and is not altered by antiviral therapy. Pol J Pathol. 2012;63:213-20 pubmed
    b>Vaspin was found to modulate insulin resistance (IR) and to inhibit proinflammatory and profibrogenic agents...
  45. Goktas Z, Owens S, Boylan M, Syn D, Shen C, Reed D, et al. Associations between tissue visfatin/nicotinamide, phosphoribosyltransferase (Nampt), retinol binding protein-4, and vaspin concentrations and insulin resistance in morbidly obese subjects. Mediators Inflamm. 2013;2013:861496 pubmed publisher
    Visfatin/Nampt, vaspin, and retinol binding protein-4 (RBP-4) play an important role in insulin resistance...
  46. Sawczyn T, Stygar D, Karcz Socha I, Fink J, Skrzep Poloczek B, KÅ‚osok M, et al. Long-term Effect of Ileal Transposition on Adipokine Serum Level in Zucker (Orl)-Lepr(fa) Fatty Rats. Obes Surg. 2015;25:1848-57 pubmed publisher
    ..Twenty male Zucker rats underwent IT or sham surgery. Six months after surgery, serum levels of adiponectin, vaspin, resistin, chemerin RBP4 were analyzed using ELISA kits...
  47. Tanna N, Patel K, Moore A, Dulnoan D, Edwards S, Hampson G. The relationship between circulating adiponectin, leptin and vaspin with bone mineral density (BMD), arterial calcification and stiffness: a cross-sectional study in post-menopausal women. J Endocrinol Invest. 2017;40:1345-1353 pubmed publisher
    To explore the relationship between circulating adiponectin, leptin and vaspin with bone mineral density (BMD), arterial stiffness and vascular calcification in post-menopausal women...
  48. Zieger K, Weiner J, Krause K, Schwarz M, Kohn M, Stumvoll M, et al. Vaspin suppresses cytokine-induced inflammation in 3T3-L1 adipocytes via inhibition of NFκB pathway. Mol Cell Endocrinol. 2018;460:181-188 pubmed publisher
    b>Vaspin expression is increased in white adipose tissue (WAT) of diet-induced obese mice and rats and is supposed to compensate HFD-induced inflammatory processes and insulin resistance in adipose tissue by counteracting pro-inflammatory ..
  49. Caminos J, Bravo S, Garcés M, González C, Cepeda L, González A, et al. Vaspin and amylin are expressed in human and rat placenta and regulated by nutritional status. Histol Histopathol. 2009;24:979-90 pubmed publisher
    Amylin (islet amyloid polypeptide) and vaspin (visceral adipose tissue specific serpin) are gut and adipocyte hormones involved in the regulation of body weight homeostasis...
  50. Briana D, Boutsikou M, Baka S, Gourgiotis D, Marmarinos A, Liosi S, et al. Omentin-1 and vaspin are present in the fetus and neonate, and perinatal concentrations are similar in normal and growth-restricted pregnancies. Metabolism. 2011;60:486-90 pubmed publisher
    The aim of this study was to investigate circulating concentrations of omentin-1 and vaspin (adipocytokines predominantly secreted by visceral adipose tissue and not yet investigated in perinatal life) in maternal, fetal, and neonatal ..
  51. Jia X, Wang S, Ma N, Li X, Guo L, Liu X, et al. Comparative analysis of vaspin in pregnant women with and without gestational diabetes mellitus and healthy non-pregnant women. Endocrine. 2015;48:533-40 pubmed publisher
    To explore serum vaspin, leptin, and adiponectin levels and their correlation with insulin resistance (IR) in pregnant women with and without gestational diabetes mellitus (GDM) and healthy non-pregnant women...
  52. Sperling M, Grzelak T, Pelczyńska M, Jasinska P, Bogdanski P, Pupek Musialik D, et al. Concentrations of omentin and vaspin versus insulin resistance in obese individuals. Biomed Pharmacother. 2016;83:542-547 pubmed publisher
    Omentin and vaspin are adipokines manifesting a potentially protective action against obesity-associated metabolic disturbances...
  53. Polyzos S, Kountouras J, Polymerou V, Papadimitriou K, Zavos C, Katsinelos P.  Vaspin, resistin, retinol-binding protein-4, interleukin-1? and interleukin-6 in patients with nonalcoholic fatty liver disease. Ann Hepatol. 2016;15:705-14 pubmed publisher
    ..The primary aim of this study was the evaluation of serum vaspin, resistin, retinol-binding protein (RBP)-4, interleukin (IL)-1? and IL-6 levels in NAFLD patients compared to ..
  54. Pala D, Carlos Cândido A, Leandro da Cruz L, Oliveira Barbosa P, Teixeira Silva C, Pinheiro Volp A, et al. [Not Available]. Nutr Hosp. 2016;33:265 pubmed publisher
    b>Vaspin is a newly-identifi ed adipocytokine associated with insulin resistance (IR)...
  55. Xu X, Wen J, Lu Y, Ji H, Zhuang J, Su Y, et al. Impact of age on plasma vaspin concentration in a group of normal Chinese people. J Endocrinol Invest. 2017;40:143-151 pubmed publisher
    Visceral adipose tissue-derived serine protease inhibitor (vaspin) is an adipocytokine with insulin-sensitizing effects...
  56. Yang W, Li Y, Tian T, Wang L. Serum Vaspin Concentration in Elderly Type 2 Diabetes Mellitus Patients with Differing Body Mass Index: A Cross-Sectional Study. Biomed Res Int. 2017;2017:4875026 pubmed publisher
    i>Aims. This study was to evaluate the association of serum vaspin concentrations with body mass index (BMI) among elderly patients (>60 years old). Methods...
  57. Sakamoto Y, Kameshima S, Kakuda C, Okamura Y, Kodama T, Okada M, et al. Visceral adipose tissue-derived serine protease inhibitor prevents the development of monocrotaline-induced pulmonary arterial hypertension in rats. Pflugers Arch. 2017;469:1425-1432 pubmed publisher
    Visceral adipose tissue-derived serine protease inhibitor (vaspin), a recently identified adipocytokine, inhibits inflammation, migration, and apoptosis of vascular cells...
  58. Kohan L, Zarei A, Fallahi S, Tabiee O. Association between vaspin rs2236242 gene polymorphism and polycystic ovary syndrome risk. Gene. 2014;539:209-12 pubmed publisher
    b>Vaspin, an adipocytokine that has been isolated from the visceral adipose tissue, is a member of the serine protease inhibitor family...
  59. Vehapoglu A, Ustabas F, Ozgen T, Terzioğlu Ş, Cermik B, Ozen O. Role of circulating adipocytokines vaspin, apelin, and visfatin in the loss of appetite in underweight children: a pilot trial. J Pediatr Endocrinol Metab. 2015;28:1065-71 pubmed publisher
    To investigate serum concentrations of vaspin, apelin, and visfatin in underweight children and their association with anthropometric and nutritional markers of malnutrition...
  60. Kukla M, Zwirska Korczala K, Hartleb M, Waluga M, Chwist A, Kajor M, et al. Serum chemerin and vaspin in non-alcoholic fatty liver disease. Scand J Gastroenterol. 2010;45:235-42 pubmed publisher
    Chemerin and vaspin are new adipokines which may modulate inflammatory response and insulin sensitivity in non-alcoholic fatty liver disease (NAFLD)...
  61. Fioravanti A, Simonini G, Cantarini L, Generoso M, Galeazzi M, Bacarelli M, et al. Circulating levels of the adipocytokines vaspin and omentin in patients with Kawasaki disease. Rheumatol Int. 2012;32:1481-2 pubmed publisher
  62. Breitfeld J, Heiker J, Bottcher Y, Schleinitz D, Tonjes A, Weidle K, et al. Analysis of a rare functional truncating mutation rs61757459 in vaspin (SERPINA12) on circulating vaspin levels. J Mol Med (Berl). 2013;91:1285-92 pubmed publisher
    A recent genome-wide association study suggests that genetic variation within the vaspin gene might contribute to the variability in circulating serum visceral adipose tissue-derived serine protease inhibitor (vaspin) concentrations...
  63. Feng R, Li Y, Wang C, Luo C, Liu L, Chuo F, et al. Higher vaspin levels in subjects with obesity and type 2 diabetes mellitus: a meta-analysis. Diabetes Res Clin Pract. 2014;106:88-94 pubmed publisher
    Visceral adipose tissue-derived serpin (vaspin) was identified as a new adipocytokine. Many studies reported vaspin concentrations in obese subjects and type 2 diabetes mellitus (T2DM) patients...
  64. Ataseven A, Kesli R. Novel inflammatory markers in psoriasis vulgaris: vaspin, vascular adhesion protein-1 (VAP-1), and YKL-40. G Ital Dermatol Venereol. 2016;151:244-50 pubmed
    Psoriasis is a chronic relapsing inflammatory skin disease. Vaspin, vascular adhesion protein-1 (VAP-1), chitinase-3-like protein 1 (also known as YKL-40), and high-sensitivity C-reactive protein (hs-CRP) are inflammatory biomarkers...
  65. Yang L, Chen S, Yuan G, Wang D, Chen J. Changes and clinical significance of serum vaspin levels in patients with type 2 diabetes. Genet Mol Res. 2015;14:11356-61 pubmed publisher
    We investigated serum visceral adipose tissue-derived serpin (vaspin) levels in patients with normal glucose regulation and recently diagnosed type 2 diabetes (T2DM) and explored the association between vaspin and body mass index, age, ..
  66. Doğan K, Ekin M, Helvacioglu C, Yasar L. Can serum vaspin levels predict clomiphene resistance in infertile women with PCOS?. Eur J Obstet Gynecol Reprod Biol. 2017;217:6-11 pubmed publisher
    To determine whether serum vaspin levels can predict the success of ovulation induction and clomiphene resistance in anovulatory women with PCOS. We designed a prospective case control study...
  67. Calikoglu C, Cakir M, Kutlu Kotan Z, Ozdemir G, Özel L, Ferah I. Should we use the serum vaspin level for the diagnosis and/or prognosis of subarachnoid hemorrhage?. J Neurosurg Sci. 2017;61:481-485 pubmed publisher
    We aimed to investigate whether vaspin, a member of the serine protease family, could be used as a marker for the severity and prognosis of subarachnoid hemorrhage (SAH). Fifty-two consecutive patients (mean age, 51.46±3.2 years; 61...
  68. Jackson V, Ntalla I, Sayers I, Morris R, Whincup P, Casas J, et al. Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12. Thorax. 2016;71:501-9 pubmed publisher
    ..FEV1 in cases, the strongest association was shown for a splice variant in a previously unreported region, SERPINA12 (rs140198372, pmeta=5.72×10(-6))...
  69. Aktas B, Yilmaz Y, Eren F, Yonal O, Kurt R, Alahdab Y, et al. Serum levels of vaspin, obestatin, and apelin-36 in patients with nonalcoholic fatty liver disease. Metabolism. 2011;60:544-9 pubmed publisher
    The novel adipokines vaspin, obestatin, and apelin-36 are associated with insulin resistance and the components of the metabolic syndrome...
  70. Yilmaz Y, Kurt R, Gurdal A, Alahdab Y, Yonal O, Senates E, et al. Circulating vaspin levels and epicardial adipose tissue thickness are associated with impaired coronary flow reserve in patients with nonalcoholic fatty liver disease. Atherosclerosis. 2011;217:125-9 pubmed publisher
    ..the relation of epicardial fat thickness, serum levels of epicardial fat-related adipokines (chemerin and vaspin), and CFR in patients with NAFLD...
  71. Yan M, Su B, Peng W, Li L, Li H, Zhuang J, et al. Association of serum vaspin and adiponectin levels with renal function in patients with or without type 2 diabetes mellitus. J Diabetes Res. 2014;2014:868732 pubmed publisher
    b>Vaspin and adiponectin are two adipocytokines with antidiabetic effects. Some studies reported that levels of adiponectin and vaspin were correlated with decreased glomerular filtration rate (FGR) and increased albuminuria...
  72. Lu H, Fouejeu Wamba P, Lapointe M, Poirier P, Martin J, Bastien M, et al. Increased vaspin levels are associated with beneficial metabolic outcome pre- and post-bariatric surgery. PLoS ONE. 2014;9:e111002 pubmed publisher
    b>Vaspin (visceral-adipose-tissue-derived-serine-protease-inhibitor) is a recently identified adipokine with putative insulin-sensitizing properties. Plasma vaspin responses to surgery-induced weight loss are sparse and contradictory...
  73. Ahmad Raston N, Nguyen V, Gu M. A new lateral flow strip assay (LFSA) using a pair of aptamers for the detection of Vaspin. Biosens Bioelectron. 2017;93:21-25 pubmed publisher
    ..This new LFSA biosensor system utilizes a cognate aptamer duo binding to vaspin, a target protein, at the two different binding sites, and exhibited a sensitive and highly selective response to ..
  74. Wyskida K, Franik G, Wikarek T, Owczarek A, Delroba A, Chudek J, et al. The levels of adipokines in relation to hormonal changes during the menstrual cycle in young, normal-weight women. Endocr Connect. 2017;6:892-900 pubmed publisher
    The aim of this study was to assess the plasma leptin, adiponectin, resistin, visfatin/NAMPT, omentin-1, vaspin, apelin, TNF-?, IL-6 and RBP4 levels in relation to hormonal changes during the menstrual cycle in young, healthy, normal-..
  75. Vink R, Roumans N, Mariman E, van Baak M. Dietary weight loss-induced changes in RBP4, FFA, and ACE predict weight regain in people with overweight and obesity. Physiol Rep. 2017;5: pubmed publisher
    ..insulin, glucose, angiotensin-converting enzyme (ACE) activity, IL-6, RBP4, apelin, leptin, adiponectin, vaspin, and nesfatin-1 concentrations. Weight loss was similar between groups (LCD: -8.2 ± 0.5 kg; VLCD: -8.9 ± 0...
  76. Jung C, Lee W, Hwang J, Seol S, Kim Y, Lee Y, et al. Vaspin protects vascular endothelial cells against free fatty acid-induced apoptosis through a phosphatidylinositol 3-kinase/Akt pathway. Biochem Biophys Res Commun. 2011;413:264-9 pubmed publisher
    b>Vaspin, an adipocytokine recently identified in a rat model of type 2 diabetes, has been suggested to have an insulin-sensitizing effect. However, the exact mechanism underlying this action has not been fully elucidated...
  77. Hida K, Poulsen P, Teshigawara S, Nilsson E, Friedrichsen M, Ribel Madsen R, et al. Impact of circulating vaspin levels on metabolic variables in elderly twins. Diabetologia. 2012;55:530-2 pubmed publisher
  78. Motal M, Klaus D, Lebherz Eichinger D, Tudor B, Hamp T, Wiegele M, et al. Increased plasma vaspin concentration in patients with sepsis: an exploratory examination. Biochem Med (Zagreb). 2015;25:90-6 pubmed publisher
    b>Vaspin (visceral adipose tissue-derived serpin) was first described as an insulin-sensitizing adipose tissue hormone. Recently its anti-inflammatory function has been demonstrated...
  79. Ostrowska Z, Ziora K, Oswiecimska J, Swietochowska E, Marek B, Kajdaniuk D, et al. Vaspin and selected indices of bone status in girls with anorexia nervosa. Endokrynol Pol. 2016;67:599-606 pubmed publisher
    In vitro studies indicate that vaspin may act as a regulator of bone metabolism...
  80. Wang Y, Yu Z, Cheng Y, Jia B, Yu G, Yin X, et al. Serum vaspin level as a predictive indicator in the amelioration of fatty liver and metabolic disturbance in patients with severe obesity after laparoscopic vertical banded gastroplasty. Medicine (Baltimore). 2017;96:e7498 pubmed publisher
    This study is all about predicting the value of serum vaspin level in the amelioration of fatty liver and metabolic disturbance in patients with severe obesity after laparoscopic vertical banded gastroplasty (LVBG)...
  81. Waluga M, Kukla M, Zorniak M, Grabiec M, Kajor M, Dyaczyński M, et al. Vaspin mRNA levels in the liver of morbidly obese women with nonalcoholic fatty liver disease. Pol J Pathol. 2017;68:128-137 pubmed publisher
    The aim of this study was to evaluate hepatic vaspin mRNA in morbidly obese women with nonalcoholic fatty liver disease (NAFLD) and to look for its relationships with metabolic and histopathological features...
  82. Namciu S, Friedman R, Marsden M, Sarausad L, Jasoni C, Fournier R. Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. Mamm Genome. 2004;15:162-78 pubmed
    ..Several differences between the MAR-Wiz predictions and the results of biochemical tests were observed. The genomic organization of the serpin gene cluster is discussed. ..
  83. Escobar Morreale H, Luque Ramírez M, San Millan J. Serum visceral adipose tissue-derived serine protease inhibitor concentrations in human obesity and polycystic ovary syndrome. Diabetes Care. 2009;32:e6 pubmed publisher
  84. Kafalidis G, Boutsikou T, Briana D, Boutsikou M, Marmarinos A, Baka S, et al. Adipokines vaspin and omentin-1 are up-regulated in large for gestational age infants at term. Cytokine. 2013;62:70-4 pubmed publisher
    ..to investigate in LGA and AGA infants possible alterations in cord blood levels of insulin and the adipokines vaspin and omentin-1 which are secreted by the adipose tissue and are implicated in insulin resistance/metabolic syndrome...
  85. Dai R, Dong Z, Qian Y, Han Y. Obese type 2 diabetes mellitus patients have higher serum vaspin concentrations. J Diabetes. 2016;8:445-7 pubmed publisher
  86. Li H, Zhang H, Jian W, Li Q, Peng W, Xu Y. Association of vaspin gene polymorphisms with coronary artery disease in Chinese population and function study. Clin Chim Acta. 2013;415:233-8 pubmed publisher
    Visceral adipose tissue-derived serine protease inhibitor (vaspin) is a recently identified adipokine. Studies suggest it is involved in many diseases such as obesity, diabetes and coronary artery disease (CAD)...
  87. Li Z, Ma C, Li L, Pan X, Chen L. Vaspin serum concentration in patients with type 2 diabetes and carotid plaque. J Int Med Res. 2012;40:1670-6 pubmed
    To examine whether there is an association between the serum concentration of vaspin and the presence of carotid plaque in early stage type 2 diabetes mellitus (T2DM)...
  88. Breitfeld J, Tonjes A, Gast M, Schleinitz D, Bluher M, Stumvoll M, et al. Role of vaspin in human eating behaviour. PLoS ONE. 2013;8:e54140 pubmed publisher
    The adipokine vaspin (visceral adipose tissue derived serine protease inhibitor, serpinA12) follows a meal-related diurnal variation in humans and intracerebroventricular vaspin administration leads to acutely reduced food intake in db/..
  89. Zhang B, Peng W, Wang K, Li H, Xu Y. Vaspin as a Prognostic Marker in Patients with Acute Myocardial Infarction. Heart Lung Circ. 2016;25:257-64 pubmed publisher
    Our previous study showed that patients with acute myocardial infarction (AMI) had lower levels of vaspin than patients without AMI. The aim of this study was to investigate the clinical significance of vaspin in patients with AMI...
  90. Kukla M, Waluga M, Żorniak M, Berdowska A, Wosiewicz P, Sawczyn T, et al. Serum omentin and vaspin levels in cirrhotic patients with and without portal vein thrombosis. World J Gastroenterol. 2017;23:2613-2624 pubmed publisher
    To investigate serum omentin and vaspin levels in cirrhotic patients; and to assess the relationship of these levels with hemostatic parameters, metabolic abnormalities, cirrhosis severity and etiology...
  91. Gkiomisi A, Makedou K, Anastasilakis A, Polyzos S, Kourtis A, Gerou S, et al. Serum vaspin levels in women with and without gestational diabetes mellitus during pregnancy and postpartum. Cytokine. 2013;61:127-32 pubmed publisher
    Although vaspin is regarded an insulin-sensitizing adipokine, its role in gestational diabetes mellitus (GDM) is currently unknown...
  92. Mehanna E, Mesbah N, Ghattas M, Saleh S, Abo Elmatty D. Association of chemerin Rs17173608 and vaspin Rs2236242 gene polymorphisms with metabolic syndrome in Egyptian women. Endocr Res. 2016;41:43-8 pubmed publisher
    ..The adipokines, chemerin and vaspin, are known to have metabolic regulatory roles...