SERCA2

Summary

Gene Symbol: SERCA2
Description: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Alias: ATP2B, DAR, SERCA2, ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2, SR Ca(2+)-ATPase 2, calcium pump 2, calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, cardiac Ca2+ ATPase, endoplasmic reticulum class 1/2 Ca(2+) ATPase, sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Species: human

Top Publications

  1. ncbi S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide
    Takeshi Adachi
    Vascular and Myocardial Biology Units, Whitaker Cardiovascular Institute, Boston University Medical Center, X707, 650 Albany Street, Boston, Massachusetts 02118 2393, USA
    Nat Med 10:1200-7. 2004
  2. pmc The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival
    Elizabeth Vafiadaki
    Molecular Biology Division, Biomedical Research Foundation, Academy of Athens, Greece
    Mol Biol Cell 20:306-18. 2009
  3. pmc Up-regulation of transient receptor potential canonical 1 (TRPC1) following sarco(endo)plasmic reticulum Ca2+ ATPase 2 gene silencing promotes cell survival: a potential role for TRPC1 in Darier's disease
    Biswaranjan Pani
    Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA
    Mol Biol Cell 17:4446-58. 2006
  4. ncbi Modulation of endoplasmic reticulum calcium pump by Bcl-2
    T H Kuo
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Oncogene 17:1903-10. 1998
  5. ncbi Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1
    Takashi Kimura
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra ACT 2601, Australia
    Hum Mol Genet 14:2189-200. 2005
  6. pmc Modulation of B-cell endoplasmic reticulum calcium homeostasis by Epstein-Barr virus latent membrane protein-1
    Olivier Dellis
    Institut National de la Sante et de la Recherche Medicale, Inserm UMR S 940, Institut Universitaire d Hematologie, Universite Paris VII, Service d Anatomie et Cytologie Pathologiques, Hopital Lariboisiere, 16, Rue de la Grange aux Belles, 75010 Paris, France
    Mol Cancer 8:59. 2009
  7. ncbi Spectrum of novel ATP2A2 mutations in patients with Darier's disease
    A Sakuntabhai
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Hum Mol Genet 8:1611-9. 1999
  8. ncbi Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization of Darier disease (SERCA2) mutants by steady-state and transient kinetic analyses
    Leonard Dode
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    J Biol Chem 278:47877-89. 2003
  9. pmc The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels
    Taj D King
    Department of Psychiatry and Behavioral Neurobiology, Sparks Center 1009, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Exp Cell Res 312:3693-700. 2006
  10. ncbi The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors
    Laura L Wootton
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Biol Chem 281:6970-6. 2006

Detail Information

Publications186 found, 100 shown here

  1. ncbi S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide
    Takeshi Adachi
    Vascular and Myocardial Biology Units, Whitaker Cardiovascular Institute, Boston University Medical Center, X707, 650 Albany Street, Boston, Massachusetts 02118 2393, USA
    Nat Med 10:1200-7. 2004
    ..Thus, irreversible oxidation of key thiol(s) in disease impairs NO-induced relaxation by preventing reversible S-glutathiolation and activation of SERCA by NO/ONOO(-)...
  2. pmc The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival
    Elizabeth Vafiadaki
    Molecular Biology Division, Biomedical Research Foundation, Academy of Athens, Greece
    Mol Biol Cell 20:306-18. 2009
    ..In the current study, we determined that HAX-1 can also bind to SERCA2. Deletion mapping analysis demonstrated that amino acid residues 575-594 of SERCA2's nucleotide binding domain are ..
  3. pmc Up-regulation of transient receptor potential canonical 1 (TRPC1) following sarco(endo)plasmic reticulum Ca2+ ATPase 2 gene silencing promotes cell survival: a potential role for TRPC1 in Darier's disease
    Biswaranjan Pani
    Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA
    Mol Biol Cell 17:4446-58. 2006
    ..Similar up-regulation of TRPC1 was also detected in epidermal layers of SERCA2+/- mice. HaCaT cells expressed TRPC1 in the plasma membrane...
  4. ncbi Modulation of endoplasmic reticulum calcium pump by Bcl-2
    T H Kuo
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Oncogene 17:1903-10. 1998
    ..The steady state levels of SERCA2 mRNA and protein were both increased in Bcl-2 expression clones...
  5. ncbi Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1
    Takashi Kimura
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra ACT 2601, Australia
    Hum Mol Genet 14:2189-200. 2005
    ..In addition, a novel variant of SERCA2 was significantly decreased in DM1 patients...
  6. pmc Modulation of B-cell endoplasmic reticulum calcium homeostasis by Epstein-Barr virus latent membrane protein-1
    Olivier Dellis
    Institut National de la Sante et de la Recherche Medicale, Inserm UMR S 940, Institut Universitaire d Hematologie, Universite Paris VII, Service d Anatomie et Cytologie Pathologiques, Hopital Lariboisiere, 16, Rue de la Grange aux Belles, 75010 Paris, France
    Mol Cancer 8:59. 2009
    ....
  7. ncbi Spectrum of novel ATP2A2 mutations in patients with Darier's disease
    A Sakuntabhai
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Hum Mol Genet 8:1611-9. 1999
    ..These results illustrate the considerable diversity of ATP2A2 mutations causing DD and suggest that additional factors are important contributors to the clinical phenotype...
  8. ncbi Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization of Darier disease (SERCA2) mutants by steady-state and transient kinetic analyses
    Leonard Dode
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    J Biol Chem 278:47877-89. 2003
    ..partial reactions of the Ca2+ transport cycle mediated by the human sarco(endo)plasmic reticulum Ca2+-ATPase 2 (SERCA2) isoforms, SERCA2a and SERCA2b, and 10 Darier disease (DD) mutants upon heterologous expression in HEK-293 cells...
  9. pmc The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels
    Taj D King
    Department of Psychiatry and Behavioral Neurobiology, Sparks Center 1009, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Exp Cell Res 312:3693-700. 2006
    ..GSK3 activity is known to affect sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) levels...
  10. ncbi The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors
    Laura L Wootton
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Biol Chem 281:6970-6. 2006
    ....
  11. ncbi Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease
    A Sakuntabhai
    The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Nat Genet 21:271-7. 1999
    ..mutations in the ATP2A2 gene, which encodes the sarco/endoplasmic reticulum Ca2(+)-ATPase type 2 isoform (SERCA2) and is highly expressed in keratinocytes...
  12. ncbi Identification of a new SERCA2 splice variant regulated during monocytic differentiation
    Pascal Gelebart
    U 348 INSERM, IFR 6, Hopital Lariboisiere, 8, rue Guy Patin, 75010 Paris, France
    Biochem Biophys Res Commun 303:676-84. 2003
    ..We report that in addition to the ubiquitously expressed SERCA2b isoform, a new splice variant of SERCA2 can be detected (SERCA2c) that arises from the inclusion of a short intronic sequence located between exons 20 and ..
  13. ncbi Physical interactions between phospholamban and sarco(endo)plasmic reticulum Ca2+-ATPases are dissociated by elevated Ca2+, but not by phospholamban phosphorylation, vanadate, or thapsigargin, and are enhanced by ATP
    M Asahi
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    J Biol Chem 275:15034-8. 2000
    ....
  14. pmc Ca2+ increase and Ca(2+)-influx in human tracheal smooth muscle cells: role of Ca2+ pools controlled by sarco-endoplasmic reticulum Ca(2+)-ATPase 2 isoform
    Y Amrani
    INSERM U 425, , Illkirch, France
    Br J Pharmacol 115:1204-10. 1995
    ..4. Comparative western blotting of human TSMC membranes using anti-SERCA2 isoform-specific antibodies clearly showed the greater expression of the 100-kDa SERCA2-b isoform compared with ..
  15. ncbi Association between carriage of oral yeasts, malnutrition and HIV-1 infection among Tanzanian children aged 18 months to 5 years
    F Scheutz
    Department of Oral Epidemiology and Public Health, Faculty of Health Sciences, Aarhus University, Denmark
    Community Dent Oral Epidemiol 25:193-8. 1997
    ..The study was carried out in Dar-es-Salaam, Tanzania, in two maternal and child health (MCH) clinics that offer routine medical checkups to all ..
  16. ncbi Dental caries in relation to diet, saliva and cariogenic microorganisms in Tanzanians of selected age groups
    M C Mazengo
    Faculty of Dentistry, University of Kuopio, Finland
    Community Dent Oral Epidemiol 24:169-74. 1996
    ..A random sample of 12-, 35-44- and 65- to 74- year olds was drawn from Msongola (rural) and Ukombozi (urban), Dar-es-Salaam. The mean of two 24-h recalls was used for the assessment of food intake...
  17. ncbi Headache in a nonclinical population in Dar es Salaam, Tanzania. A community-based study
    W B Matuja
    Neurology Clinic, Muhimbili University College of Health Sciences, University of Dar es Salaam, Tanzania
    Headache 35:273-6. 1995
    ..3 lost work days per year in comparison to a control group of 154 persons with an average of 5.7 lost work days per year for reasons other than headache (X2 P = 0.0005).(ABSTRACT TRUNCATED AT 250 WORDS)..
  18. doi Darier disease, multiple bone cysts, and aniridia due to double de novo heterozygous mutations in ATP2A2 and PAX6
    Marco Castori
    Experimental Medicine Department, Sapienza University of Rome, San Camillo Forlanini Hospital, Italy
    Am J Med Genet A 149:1768-72. 2009
    ..This finding suggests a role for ATP2A2 in bone biology. More systematic studies are expected in order to estimate the true prevalence of bone cysts in DD and the relationship between skeletal changes and ATP2A2 perturbation...
  19. pmc Current clinical efficacy of chloroquine for the treatment of Plasmodium falciparum infections in urban Dar es Salaam, United Republic of Tanzania
    Z Premji
    Department of Parasitology Medical Entomology, Muhimbili University College of Health Sciences, Dar es Salaam, United Republic of Tanzania
    Bull World Health Organ 77:740-4. 1999
    ..the efficacy of chloroquine in the treatment of uncomplicated malaria in young children (n = 200) in urban Dar es Salaam. Chloroquine failure was found in 43% of the children. Of these, 12...
  20. ncbi Anti-diabetic drugs in the private and public sector in Dar es Salaam, Tanzania
    M Justin-Temu
    Department of Pharmaceutics, School of Pharmacy, Muhimbili University of Health and Allied Sciences, P O Box 65013, Dares Salaam, Tanzania
    East Afr Med J 86:110-4. 2009
    To compare availability, cost, affordability and sources of anti-diabetic drugs between private and public health facilities in Dar es Salaam, Tanzania.
  21. doi No indications for HPV involvement in the hypertrophic skin lesions of a Darier disease case without ATP2A2 gene mutations
    Cinzia Borgogna
    Department of Clinical and Experimental Medicine, Medical School of Novara, University of Piemonte Orientale Amedeo Avogadro, Novara, Italy
    J Cutan Pathol 36:1005-9. 2009
    ..Haploinsufficiency of the ATP2A2 gene product, sarco/endoplasmic reticulum Ca(2+) ATPase isoform 2 (SERCA2), is the underlying cause of most cases...
  22. doi A novel splice-site mutation of ATP2A2 gene in a Chinese family with Darier disease
    Jia Huo
    Department of Dermatology, The Second Hospital of Xi an Jiaotong University, 157 Xi Wu Road, Xi an, 710004 Shaanxi, People s Republic of China
    Arch Dermatol Res 302:769-72. 2010
    ..of DD are defects in the ATP2A2 gene, which encodes the sarco/endoplasmic reticulum Ca(2+) ATPase isoform 2 (SERCA2)...
  23. ncbi Assessment of sarcoplasmic reticulum Ca(2+) flux pathways in cardiomyocytes from rabbits with infarct-induced left-ventricular dysfunction
    Paul Neary
    Department of Medical Cardiology, Glasgow Royal Infirmary, Glasgow G31 2ER, UK
    Pflugers Arch 444:360-71. 2002
    ..SR Ca(2+) flux rates associated with sarco-endoplasmic reticulum Ca(2+) ATPase type 2 (SERCA2)-mediated uptake, ryanodine receptor type 2 (RyR2)-mediated Ca(2+) efflux and background SR Ca(2+) leak were ..
  24. ncbi Squamous cell tumors in mice heterozygous for a null allele of Atp2a2, encoding the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 Ca2+ pump
    L H Liu
    Departments of Molecular Genetics, Biochemistry and Microbiology and Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 276:26737-40. 2001
    Mutations in the human ATP2A2 gene, encoding sarco(endo)plasmic reticulum Ca(2+)-ATPase isoform 2 (SERCA2), cause Darier disease, an autosomal dominant skin disease characterized by multiple keratotic papules in the seborrheic regions of ..
  25. doi Clinical and mutational heterogeneity of Darier disease in Tunisian families
    Mbarka Bchetnia
    Molecular Investigation of Genetic Orphan Diseases Research Unit and Department of Pathology, Institut Pasteur de Tunis, Tunis, Tunisia
    Arch Dermatol 145:654-6. 2009
    ..To study the mutation spectrum and phenotype-genotype correlation of Darier disease (DD) in Tunisian patients...
  26. ncbi Darier disease: a guide to the physician
    Aleksandar Godic
    Department of Dermatovenereology, University Clinical Centre, Ljubljana, Slovenia
    J Med 35:5-17. 2004
    ..It is caused by mutations of ATP2A2 gene, which encodes the sarco/endoplasmic reticulum Ca2+ ATPase isoform 2 (SERCA2 protein)...
  27. pmc Cardiac hypertrophy and thyroid hormone signaling
    Wolfgang Dillmann
    University of California, San Diego, USA
    Heart Fail Rev 15:125-32. 2010
    ..with thyroid hormone promoting expression of the gene encoding the calcium pump of the sarcoplasmic reticulum (SERCa2). In contrast, in hypothyroid animals phospholamban levels, which inhibit the SERCa2 pump, are increased...
  28. doi New mutations of Darier disease in Tunisian patients
    Mbarka Bchetnia
    Molecular Investigation of Genetic Orphan Diseases Research Unit, Institut Pasteur de Tunis, Pasteur, 1002 Tunis Belvedere, Tunisia
    Arch Dermatol Res 301:615-9. 2009
    ..Both pathogenic mutations are located in exon 13 of the ATP2A2 gene and affected the ATP-binding site of the SERCA2 protein...
  29. ncbi A monoclonal antibody to the Ca2+-ATPase of cardiac sarcoplasmic reticulum cross-reacts with slow type I but not with fast type II canine skeletal muscle fibers: an immunocytochemical and immunochemical study
    A O Jorgensen
    Department of Anatomy, University of Toronto, Ontario, Canada
    Cell Motil Cytoskeleton 9:164-74. 1988
    ....
  30. ncbi Evaluation of the quality of amodiaquine and sulphadoxine/pyrimethamine tablets sold by private wholesale pharmacies in Dar Es Salaam Tanzania
    O M S Minzi
    Clinical Pharmacology Department, Faculty of Medicine, Muhimbili University College of Health Sciences MUCHS, Dar es Salaam, Tanzania
    J Clin Pharm Ther 28:117-22. 2003
    ..The aim of this work was to assess the quality of SP and AQ tablets marketed by wholesale pharmacies in Dar Es Salaam, Tanzania.
  31. ncbi Consequences of depleted SERCA2-gated calcium stores in the skin
    Eliane J Muller
    Vetsuisse Faculty, Institute of Animal Pathology, University of Bern, Bern, Switzerland
    J Invest Dermatol 126:721-31. 2006
    Sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) pumps belong to the family of Ca2+-ATPases responsible for the maintenance of calcium in the endoplasmic reticulum...
  32. ncbi Food cravings, aversions and pica among pregnant women in Dar es Salaam, Tanzania
    C N M Nyaruhucha
    Sokoine University of Agriculture, Department of Food Science and Technology, P O Box 3006, Morogoro, Tanzania
    Tanzan J Health Res 11:29-34. 2009
    ..aversions and pica during pregnancy among 204 pregnant and lactating women attending two health facilities in Dar es Salaam City, Tanzania. Nausea and vomiting were reported by 82.8% of all women of which 43...
  33. pmc Interplay of RNA elements in the dengue virus 5' and 3' ends required for viral RNA replication
    Peter Friebe
    Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, 1 Barker Hall, Berkeley, CA 94720 7354, USA
    J Virol 84:6103-18. 2010
    ..This new sequence is located downstream of the AUG, designated the 5' downstream AUG region (5' DAR); the motif predicted to be complementary in the 3' end is termed the 3' DAR...
  34. ncbi Nature of gram-negative rod antibiotic resistance during antibiotic rotation
    Heather L Evans
    Surgical Infectious Disease Research Laboratory, Department of Surgery, UVA Health System, Charlottesville, VA 22908 1380, USA
    Surg Infect (Larchmt) 6:223-31. 2005
    ..The aim of this study was to characterize the evolution of gram-negative antibiotic resistance during a study of empiric antibiotic rotation...
  35. pmc A new tent trap for sampling exophagic and endophagic members of the Anopheles gambiae complex
    Nicodemus J Govella
    Ifakara Health Institute, Coordination Office, Dar es Salaam, United Republic of Tanzania
    Malar J 8:157. 2009
    Mosquito sampling methods are essential for monitoring and evaluating malaria vector control interventions. In urban Dar es Salaam, human landing catch (HLC) is the only method sufficiently sensitive for monitoring malaria-transmitting ..
  36. doi Prevention of mother-to-child transmission of HIV-1 through breastfeeding by treating mothers with triple antiretroviral therapy in Dar es Salaam, Tanzania: the Mitra Plus study
    Charles Kilewo
    Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
    J Acquir Immune Defic Syndr 52:406-16. 2009
    ..The main aim of this study was to reduce breast-milk transmission of HIV-1 by treating HIV-1-infected women with highly active antiretroviral therapy (HAART) during breastfeeding...
  37. pmc Optimal blood mononuclear cell isolation procedures for gamma interferon enzyme-linked immunospot testing of healthy Swedish and Tanzanian subjects
    C Nilsson
    Dept of Immunology and Vaccinology, Swedish Institute for Infectious Disease Control and Karolinska Institute, 171 82 Solna, Sweden
    Clin Vaccine Immunol 15:585-9. 2008
    ..to find the cell preparation technique best suited for two clinical vaccine trial sites: Stockholm, Sweden, and Dar es Salaam, Tanzania...
  38. ncbi Sarco/endoplasmic reticulum calcium ATPase-2 expression is regulated by ATF6 during the endoplasmic reticulum stress response: intracellular signaling of calcium stress in a cardiac myocyte model system
    D J Thuerauf
    Heart Institute and the Department of Biology, San Diego State University, San Diego, California 92182, USA
    J Biol Chem 276:48309-17. 2001
    ..the hypothesis that ATF6 serves as a regulator of the expression of sarco/endoplasmic reticulum calcium ATPase-2 (SERCA2), a protein that transports calcium into the SR from the cytoplasm...
  39. pmc Maternal and neonatal colonisation of group B streptococcus at Muhimbili National Hospital in Dar es Salaam, Tanzania: prevalence, risk factors and antimicrobial resistance
    Agricola Joachim
    Department of Microbiology and Immunology, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
    BMC Public Health 9:437. 2009
    ..This study was conducted in Dar es Salaam, Tanzania to determine the prevalence of GBS colonisation among pregnant women, the neonatal colonisation ..
  40. pmc Community response to artemisinin-based combination therapy for childhood malaria: a case study from Dar es Salaam, Tanzania
    Vinay R Kamat
    Department of Anthropology, University of British Columbia, Vancouver, Canada
    Malar J 9:61. 2010
    ..The paper specifically examines the perceived efficacy of ALu as articulated by the mothers of young children diagnosed with malaria and prescribed ALu...
  41. ncbi The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling
    Wen Zhao
    Department of Pharmacology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0575, USA
    Circulation 113:995-1004. 2006
    Phospholamban (PLN) is an inhibitor of the Ca2+ affinity of sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2)...
  42. ncbi Adolescent girls with illegally induced abortion in Dar es Salaam: the discrepancy between sexual behaviour and lack of access to contraception
    V Rasch
    Department of Obstetrics and Gynaecology, Odense University Hospital, DK 5000 Odense C, Denmark
    Reprod Health Matters 8:52-62. 2000
    This article reports on a study of induced abortion among adolescent girls in Dar es Salaam, Tanzania, who were admitted to a district hospital in Dar es Salaam because of an illegally induced abortion in 1997...
  43. ncbi Protein kinase C mediates phosphorylation, desensitization, and trafficking of the D2 dopamine receptor
    Yoon Namkung
    Molecular Neuropharmacology Section, NINDS, National Institutes of Health, Bethesda, Maryland 20892 1406, USA
    J Biol Chem 279:49533-41. 2004
    ..protein kinase A (PKA) and protein kinase C (PKC), to mediate phosphorylation and desensitization of the D2 DAR. HEK293T cells were transiently transfected with the D2 DAR and then treated with intracellular activators and ..
  44. ncbi Influences of increased expression of the Ca2+ ATPase of the sarcoplasmic reticulum by a transgenic approach on cardiac contractility
    W H Dillmann
    Department of Medicine, University of California, San Diego 92093 0618, USA
    Ann N Y Acad Sci 853:43-8. 1998
    ..The Ca2+ ATPase of the sarcoplasmic reticulum (SERCA2) contributes in an important manner to diastolic Ca2+ lowering and relaxation of the heart...
  45. ncbi Causes, magnitude and management of burns in under-fives in district hospitals in Dar es Salaam, Tanzania
    M Justin-Temu
    Dept of Pharmaceutics, School of Pharmacy, MUHAS
    East Afr J Public Health 5:38-42. 2008
    To determine the causes, magnitude and management of burns in children under five years of age who were admitted in the district hospitals of Dar es Salaam City, Tanzania.
  46. ncbi Late postnatal transmission of human immunodeficiency virus type 1 infection from mothers to infants in Dar es Salaam, Tanzania
    K Karlsson
    Swedish Institute for Infectious Disease Control, Karolinska Institute, Stockholm
    Pediatr Infect Dis J 16:963-7. 1997
    To study late postnatal transmission of human immunodeficiency virus type 1 in a cohort of children born to HIV-1-seropositive mothers who delivered at Muhimbili Medical Centre in Dar es Salaam, Tanzania.
  47. pmc Knowledge of mosquitos in relation to public and domestic control activities in the cities of Dar es Salaam and Tanga
    C Stephens
    Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, England
    Bull World Health Organ 73:97-104. 1995
    A study of community awareness of mosquitos and related subjects in the residential areas of two Tanzanian cities (Dar es Salaam and Tanga) showed that residents were well aware of mosquitos...
  48. ncbi Cardiac dysfunction occurs in the HIV-1 transgenic mouse treated with zidovudine
    W Lewis
    Department of Pathology, University of Cincinnati College of Medicine, Ohio, USA
    Lab Invest 80:187-97. 2000
    ..echocardiographic studies were performed and abundance of mRNA for cardiac sarcoplasmic reticulum calcium ATPase (SERCA2), sodium calcium exchanger (NCX1), and atrial natriuretic factor were determined individually using Northern ..
  49. ncbi Autoreceptor mechanism regulating carotid body dopamine release from adult and 10-day-old rabbits
    A Bairam
    Unité de Recherche en Périnatologie, Centre Hospitalier Universitaire de Quebec, PQ, Canada
    Respir Physiol 120:27-34. 2000
    ..We tested the hypothesis that CB DAr is autoregulated in a concentration and age dependent manner. Using an in vitro CB infusion model [Bairam, A...
  50. pmc Evaluation of simple rapid HIV assays and development of national rapid HIV test algorithms in Dar es Salaam, Tanzania
    Eligius F Lyamuya
    Department of Microbiology and Immunology, Muhimbilli University of Health and Allied Sciences, Dar es Salaam, Tanzania
    BMC Infect Dis 9:19. 2009
    ....
  51. ncbi [Effects of valsartan on sarcoplasmic reticulum calcium adenosine triphosphatase, protein kinase A and protein phosphatase 1 alpha in a rabbit model of heart failure]
    Fu Zheng Qu
    Department of Cardiology, The First Affiliated Hospital of Suzhou University, Suzhou 215006, China
    Zhonghua Xin Xue Guan Bing Za Zhi 36:790-3. 2008
    To investigate the effects of valsartan on expressions of myocardial sarcoplasmic reticulum calcium adenosine triphosphatase (SERCA2), protein kinase A (PKA) and protein phosphatase 1 alpha (PP1alpha) in a rabbit model of heart failure.
  52. doi Defining how aging Pseudotsuga and Abies compensate for multiple stresses through multi-criteria assessment of a functional-structural model
    Maureen C Kennedy
    University of Washington, Quantitative Ecology and Resource Management, Seattle, WA 98195 2100, USA
    Tree Physiol 30:3-22. 2010
    ..The model for branch development that we use simulates the process of delayed adaptive reiteration (DAR), whereby new foliage grows from suppressed buds within the established branch structure...
  53. ncbi Localization of intracellular Ca2+ stores in HeLa cells during infection with Chlamydia trachomatis
    M Majeed
    Divisions of Medical Microbiology and Clinical Microbiology, Faculty of Health Sciences, Linkoping University, S 581 85 Linkoping, Sweden
    J Cell Sci 112:35-44. 1999
    ..type-1 inositol-1,4, 5-trisphosphate receptor (IP3-R), and Sarcoplasmic/Endoplasmic Reticulum Ca2+ ATPase type 2 (SERCA2) in HeLa cells infected with C. trachomatis serovar L2...
  54. ncbi Dropouts in a long-term follow-up study involving voluntary counseling and HIV testing: experience from a cohort of police officers in Dar Es Salaam, Tanzania
    F Mugusi
    Muhimbili Medical Centre, Dar es Salaam, Tanzania
    J Acquir Immune Defic Syndr 30:119-23. 2002
    ..In studies with long-term follow-up, reasons for nonresponse may provide invaluable information that may be gathered through continued contact with study subjects who have withdrawn from the study...
  55. doi Myocardial gene expression alterations in peripheral blood mononuclear cells of patients with idiopathic dilated cardiomyopathy
    Joanna E Kontaraki
    Molecular Cardiology Laboratory, School of Medicine, University of Crete, Crete, Greece
    Eur J Heart Fail 12:541-8. 2010
    ..To assess cardiac gene expression in peripheral blood cells of patients with idiopathic dilated cardiomyopathy (IDCM) and its relationship to echocardiographic left ventricular (LV) function...
  56. ncbi HIV/AIDS and injection drug use in the neighborhoods of Dar es Salaam, Tanzania
    Sheryl A McCurdy
    University of Texas Health Science Center at Houston, School of Public Health, WHO Center for Health Promotion and Prevention Research, Houston, TX 77030, USA
    Drug Alcohol Depend 82:S23-7. 2006
    ..practices and HIV recovered from used syringes collected from 73 heroin injection drug users (IDUs) in Dar es Salaam, Tanzania, between October 2003 and January 2004...
  57. ncbi Urinary schistosomiasis in schoolchildren in Dar-es-Salaam, Tanzania, and the factors influencing its transmission
    R Ndyomugyenyi
    Ministry of Health, Vector Borne Diseases, P O Box 1661, Kampala, Uganda
    Ann Trop Med Parasitol 95:697-706. 2001
    ..urinary schistosomiasis among the schoolchildren living in Kigogo administrative ward of the Kinondoni district of Dar-es-Salaam city, Tanzania, and the factors influencing the transmission of the causative agent, Schistosoma ..
  58. doi Prevention of mother-to-child transmission of HIV-1 through breast-feeding by treating infants prophylactically with lamivudine in Dar es Salaam, Tanzania: the Mitra Study
    Charles Kilewo
    Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
    J Acquir Immune Defic Syndr 48:315-23. 2008
    ..To investigate the possibility of reducing mother-to-child transmission (MTCT) of HIV-1 through breast-feeding by prophylactic antiretroviral (ARV) treatment of the infant during the breast-feeding period...
  59. pmc The Diels-Alder-reaction with inverse-electron-demand, a very efficient versatile click-reaction concept for proper ligation of variable molecular partners
    Manfred Wiessler
    German Cancer Research Center, Dept of Imaging and Radiooncology, INF 280, D 69120 Heidelberg, Germany
    Int J Med Sci 7:19-28. 2009
    ..The Diels-Alder ligation Reaction with inverse electron demand (DAR(inv)) turns out to be an appropriate candidate...
  60. ncbi Organic liquids storage tanks volatile organic compounds (VOCS) emissions dispersion and risk assessment in developing countries: the case of Dar-es-Salaam City, Tanzania
    Msafiri M Jackson
    Department of Environmental Engineering, University College of Lands and Architectural Studies, P O Box 35176, Dar es Salaam, Tanzania
    Environ Monit Assess 116:363-82. 2006
    ..emission estimation of nine volatile organic compounds (VOCs) from eight organic liquids storage tanks companies in Dar-es-Salaam City Tanzania has been done by using US EPA standard regulatory storage tanks emission model (TANKS 4.9b)...
  61. pmc Mimicking a semi-arid tropical environment achieves dormancy alleviation for seeds of Australian native Goodeniaceae and Asteraceae
    G L Hoyle
    Integrated Seed Research Unit, School of Land, Crop and Food Sciences, The University of Queensland, St Lucia, QLD 4072, Australia
    Ann Bot 101:701-8. 2008
    ..It was hypothesised that optimum dormancy-alleviating treatments would reflect environmental conditions that seeds experience in situ, and this premise was tested for PD seeds of four species native to south-west Qld...
  62. ncbi Adenovirus-mediated gene transfer reconstitutes depressed sarcoplasmic reticulum Ca2+-ATPase levels and shortens prolonged cardiac myocyte Ca2+ transients
    F J Giordano
    Department of Medicine, University of California at San Diego in La Jolla, USA
    Circulation 96:400-3. 1997
    Decreased expression of the sarcoplasmic reticulum (SR) Ca2+-ATPase of the cardiac myocyte (SERCA2) and abnormal Ca2+ regulation have been independently linked to human heart failure...
  63. ncbi Constraints on good child-care practices and nutritional status in urban Dar-es-Salaam, Tanzania
    Kissa B M Kulwa
    Department of Food Science and Technology, Sokoine University of Agriculture, Morogoro, Tanzania
    Food Nutr Bull 27:236-44. 2006
    ..Although significant gains have been made in the fight against malnutrition in Tanzania, the nutritional status of preschool children in urban areas is not improving...
  64. ncbi Mechanism of doxorubicin-induced inhibition of sarcoplasmic reticulum Ca(2+)-ATPase gene transcription
    M Arai
    Second Department of Internal Medicine, Gunma University School of Medicine, Gunma, Japan
    Circ Res 86:8-14. 2000
    ..We have recently demonstrated that expression of mRNA encoding sarco(endo)plasmic reticulum Ca(2+)-ATPase 2 (SERCA2), a major Ca(2+) transport protein in SR, is markedly decreased in DOX-treated hearts...
  65. ncbi Heroin and HIV risk in Dar es Salaam, Tanzania: youth hangouts, mageto and injecting practices
    S A McCurdy
    University of Texas Health Science Center at Houston School of Public Health, Houston, TX 77030, USA
    AIDS Care 17:S65-76. 2005
    ..during the months of February and July 2003 with 51 male and female injectors residing in 8 neighbourhoods in the Dar es Salaam, Tanzania...
  66. ncbi Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene
    M Periasamy
    Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Biol Chem 274:2556-62. 1999
    The sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene encodes both SERCA2a, the cardiac sarcoplasmic reticulum Ca2+ pump, and SERCA2b, which is expressed in all tissues...
  67. ncbi Roadside concentration of gaseous and particulate matter pollutants and risk assessment in Dar-es-Salaam, Tanzania
    Msafiri M Jackson
    Department of Environmental Engineering, University College of Lands and Architectural Studies, Dar es Salaam, Tanzania tz
    Environ Monit Assess 104:385-407. 2005
    This study used manual air sampling method to assess the contribution of road traffic to air pollution level in Dar-es-Salaam City, Tanzania. Samples were collected from 11 different sites...
  68. ncbi Urban-rural contrasts in explanatory models and treatment-seeking behaviours for stroke in Tanzania
    G Mshana
    National Institute for Medical Research, Mwanza, Tanzania
    J Biosoc Sci 40:35-52. 2008
    ..project on stroke incidence, focuses on local understandings and treatment-seeking behaviours in urban (Dar-es-Salaam) and rural (Hai) areas of Tanzania...
  69. ncbi Occlusion among a group of Tanzanian urban schoolchildren
    H Kerosuo
    Division of Dentistry, University of Dar es Salaam, Tanzania
    Community Dent Oral Epidemiol 16:306-9. 1988
    Occlusion and its variations were studied in a group of primary schoolchildren (n = 642, age 11-18 yr) in Dar es Salaam. Most children (96%) had Angle's Class I occlusion...
  70. ncbi Transcription factor Sp1 regulates SERCA2 gene expression in pressure-overloaded hearts: a study using in vivo direct gene transfer into living myocardium
    Takako Takizawa
    Second Department of Internal Medicine, Gunma University School of Medicine, 3 39 15 Showa Machi, Maebashi, 371 8511, Gunma, Japan
    J Mol Cell Cardiol 35:777-83. 2003
    Pressure-overload hypertrophy results in downregulation of the sarcoplasmic reticulum Ca(2+)-ATPase pump encoding SERCA2 gene that regulates Ca(2+) uptake and myocardial relaxation...
  71. ncbi Modulating sarco(endo)plasmic reticulum Ca2+ ATPase 2 (SERCA2) activity: cell biological implications
    Peter Vangheluwe
    Laboratory of Physiology, O and N Gasthuisberg, K U Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Cell Calcium 38:291-302. 2005
    Of the three mammalian members belonging to the sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) family, SERCA2 is evolutionary the oldest and shows the most wide tissue-expression pattern...
  72. ncbi Lithium suppresses epidermal SERCA2 and PMR1 levels in the rat
    Norbert Sule
    Department of Pathology, University of Pecs, Pecs, Hungary
    Pathol Oncol Res 12:234-6. 2006
    Autosomal dominant mutations in the genes encoding the calcium ATPases SERCA2 and PMRI/SPCA1 cause the genodermatoses Darier disease (DD) and Hailey-Hailey disease (HHD), respectively...
  73. ncbi Sexual dimorphism in canine morphology
    J Dumancic
    School of Dental Medicine, University of Zagreb, Croatia
    J Forensic Odontostomatol 31:44. 2013
    ..Distal accessory ridge (DAR) of the upper and lower canines was evaluated on plaster casts using the Arizona State University (ASU) dental ..
  74. ncbi Isolation of three dormancy QTLs as Mendelian factors in rice
    X Y Gu
    Department of Plant Sciences, North Dakota State University, Fargo, ND 58105, USA
    Heredity (Edinb) 96:93-9. 2006
    ..genetic background to examine component genetic effects and their interactions with time of afterripening (DAR). A BC4F2 plant, which was heterozygous for the three loci, was selected to develop the BC4F3 population...
  75. ncbi Distribution of SERCA isoforms in human intrafusal fibers
    Jing Xia Liu
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, 901 87 Umea, Sweden
    Histochem Cell Biol 120:299-306. 2003
    ..In this study, the presence of SERCA1 and SERCA2 was investigated in human intrafusal fibers by immunocytochemistry...
  76. doi Barriers and promoters of home-based pasteurization of breastmilk among HIV-infected mothers in greater Dar es Salaam, Tanzania
    Sera Young
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
    Breastfeed Med 8:321-6. 2013
    ..Our primary objective was to explore the barriers and promoters of the implementation of breastmilk pasteurization, "flash-heating" (FH), in the real-world setting of Dar es Salaam, Tanzania.
  77. doi Prevalence of sulfadoxine-pyrimethamine resistance-associated mutations in dhfr and dhps genes of Plasmodium falciparum three years after SP withdrawal in Bahir Dar, Northwest Ethiopia
    Elifaged Hailemeskel
    Department of Biology, College of Natural Sciences, Wollo University, Dessie, Ethiopia Electronic address
    Acta Trop 128:636-41. 2013
    ..falciparum three years after SP withdrawal in Bahir Dar, Northwest Ethiopia. A total of 165 blood spot samples were collected from patients infected with P...
  78. ncbi Temperature dependence of the Ca2+-ATPase (SERCA2) in the ventricles of tuna and mackerel
    Ana M Landeira-Fernandez
    Hopkins Marine Station, Stanford Univ, Oceanview Blvd, Pacific Grove, CA, 93950, USA
    Am J Physiol Regul Integr Comp Physiol 286:R398-404. 2004
    ..The cardiac sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2) plays a major role during cardiac excitation-contraction (E-C) coupling, transporting Ca2+ from the cytosol into ..
  79. ncbi PYK2 regulates SERCA2 gene expression in neonatal rat ventricular myocytes
    Maria C Heidkamp
    The Cardiovascular Institute, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA
    Am J Physiol Cell Physiol 289:C471-82. 2005
    ..and mutant forms of PYK2 were used to determine whether PYK2 overexpression activates MAPKs, and downregulates SERCA2 mRNA levels in neonatal rat ventricular myocytes (NRVM)...
  80. doi Defining the contribution of select neuropeptides and their receptors in regulating sesquiterpenoid biosynthesis by Drosophila melanogaster ring gland/corpus allatum through RNAi analysis
    Christine Wang
    Department of Biology, Queen s University, Kingston, ON, Canada K7L 3N6
    Gen Comp Endocrinol 176:347-53. 2012
    ..an inducible UAS-RNAi construct made to either PheGlyLeu-NH(2)-allatostatin (FGLa/AST) and its cognate receptors Dar-1 and Dar-2 or PISCF-allatostatin (PISCF/AST) or its cognate receptors Drostar-1 or Drostar-2 were expressed in ..
  81. pmc Maintenance of Sensitivity of the T-SPOT.TB Assay after Overnight Storage of Blood Samples, Dar es Salaam, Tanzania
    Elizabeth A Talbot
    Dartmouth Medical School, Hanover, NH 03755, USA
    Tuberc Res Treat 2012:345290. 2012
    ..Design. Consecutive AFB smear positive adult tuberculosis patients were prospectively recruited in Dar es Salaam, Tanzania...
  82. doi Expression of SERCA and phospholamban in rainbow trout (Oncorhynchus mykiss) heart: comparison of atrial and ventricular tissue and effects of thermal acclimation
    Hanna Korajoki
    University of Eastern Finland, Department of Biology, Joensuu, Finland
    J Exp Biol 215:1162-9. 2012
    ..Quantitative PCR (SERCA only) and antibodies raised against SERCA and PLN were used to determine abundances of SERCA2 transcripts and SERCA and PLN proteins, respectively, in atrium and ventricle of trout acclimated to cold (+4°C, ..
  83. pmc SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease
    Anna Celli
    Department of Dermatology, San Francisco Veterans Administration Medical Center, San Francisco, California 94121 1545, USA
    J Invest Dermatol 132:1188-95. 2012
    ..levels increase and sphingosine kinase (SPHK1) expression decreases after inactivating SERCA2b with the specific SERCA2 inhibitors thapsigargin (TG) or small interfering RNA to SERCA2b...
  84. doi Prevalence and antimicrobial resistance profiles of Salmonella enterica serovars isolated from slaughtered cattle in Bahir Dar, Ethiopia
    Sefinew Alemu
    Department of Clinical Medicine and Epidemiology, Faculty of Veterinary Medicine, University of Gondar, Gondar, Ethiopia
    Trop Anim Health Prod 44:595-600. 2012
    ..and carcass swab samples (each n = 186) were collected from 186 apparently healthy slaughtered cattle at Bahir Dar abattoir...
  85. ncbi Cardiovascular risk factors in Tanzania: a revisit
    M Njelekela
    Department of Life Science, Environmental Conservation and Development, Graduate School of Human and Environmental Studies, Kyoto University, Yoshida nihonmatsu cho, Sakyo ku, 606 8501, Kyoto, Japan
    Acta Trop 79:231-9. 2001
    ..The survey was carried out in Dar es Salaam (D, urban), Handeni (H, rural) and Monduli (Mo, semi-nomadic area)...
  86. ncbi Exclusion of the Darier's disease gene, ATP2A2, as a common susceptibility gene for bipolar disorder
    N J Jacobsen
    Neuropsychiatric Genetics Unit, Division of Psychological Medicine, Tenovus Building, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Mol Psychiatry 6:92-7. 2001
    ..In this study we have investigated the Darier's disease gene ATP2A2, the calcium pumping ATPase SERCA2, as a potential susceptibility gene for bipolar disorder under the hypothesis that variations in SERCA2 have ..
  87. pmc Plasticity and adaptation of Ca2+ signaling and Ca2+-dependent exocytosis in SERCA2(+/-) mice
    X S Zhao
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9040, USA
    EMBO J 20:2680-9. 2001
    Darier's disease (DD) is a high penetrance, autosomal dominant mutation in the ATP2A2 gene, which encodes the SERCA2 Ca2+ pump...
  88. pmc Pharmacological characterization of 2-methoxy-N-propylnorapomorphine's interactions with D2 and D3 dopamine receptors
    Mette Skinbjerg
    Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892 9405, USA
    Synapse 63:462-75. 2009
    ..was found to robustly inhibit forskolin-stimulated cAMP accumulation to the same extent as dopamine in D(2) or D(3) DAR-transfected cells, indicating that it is a full agonist at both receptors...
  89. ncbi Prevalence of teeth with untreated dental trauma among nursery and primary school pupils in Dar es Salaam, Tanzania
    F K Kahabuka
    Faculty of Dentistry, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
    Dent Traumatol 17:109-13. 2001
    ..study was to investigate the prevalence of teeth with untreated dental trauma among children aged 4-15 years in Dar es Salaam, Tanzania...
  90. ncbi Platelet and cardiac function in Darier's disease
    S Tavadia
    Department of Dermatology, Royal Infirmary, Castle Street, Glasgow G4 OSF, UK
    Clin Exp Dermatol 26:696-9. 2001
    ATP2A2, the gene that is abnormal in Darier's disease, encodes SERCA2, a calcium pump that is expressed in many tissues. The wide expression of SERCA2 might suggest that ATP2A2 mutations would cause a multisystem disease...
  91. ncbi Assessing acceptability of parents/guardians of adolescents towards introduction of sex and reproductive health education in schools at Kinondoni Municipal in Dar es Salaam city
    Lumuli Mbonile
    School of Medicine, Muhimbili University of Health and Allied Sciences MUHAS, Dar es Salaam, Tanzania
    East Afr J Public Health 5:26-31. 2008
    ..To assess acceptability of parents/guardians of adolescents towards the introduction of sex and reproductive health education in the community and schools...
  92. ncbi Oral health status of handicapped primary school pupils in Dar es Salaam, Tanzania
    E N M Simon
    Department of Oral Surgery and Oral Pathology, School of Dentistry, Muhimbili University of Health and Allied Sciences, P O Box 65014, Dar es Salaam, Tanzania
    East Afr Med J 85:113-7. 2008
    ..Determination of their oral health status could help in planning sustainable intervention programmes for this disadvantaged group...
  93. doi Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene
    Kristin Brevik Andersson
    Institute for Experimental Medical Research, Ullevaal University Hospital, 0407 Oslo, Norway
    J Mol Cell Cardiol 47:180-7. 2009
    The sarco(endo)plasmic reticulum calcium ATPase 2 (SERCA2) transports Ca(2+) from cytosol into the sarcoplasmic reticulum (SR) of cardiomyocytes, thereby maintaining the store of releasable Ca(2+) necessary for contraction...
  94. ncbi Elevated Ca2+ ATPase (SERCA2) activity in tuna hearts: comparative aspects of temperature dependence
    Pedro C Castilho
    Tuna Research and Conservation Center, Hopkins Marine Station, Stanford University, Pacific Grove, California 93950, USA
    Comp Biochem Physiol A Mol Integr Physiol 148:124-32. 2007
    ..The cardiac SR Ca2+-ATPase (SERCA2) plays a major role during cardiac excitation-contraction (E-C) coupling...
  95. ncbi High frequency of partial DIIIa and DAR alleles found in sickle cell disease patients suggests increased risk of alloimmunization to RhD
    L Castilho
    Hemocentro Unicamp, Campinas, SP, Brazil
    Transfus Med 15:49-55. 2005
    We have set out to determine the frequency of DIIIa and DAR alleles among sickle cell disease (SCD) patients. These D variants permit the unexpected development of antibodies to RhD among individuals who are otherwise classified as RhD+...
  96. ncbi Distribution of blood pressure, body mass index and smoking habits in the urban population of Dar es Salaam, Tanzania, and associations with socioeconomic status
    Pascal Bovet
    University Institute of Social and Preventive Medicine, Lausanne, Switzerland
    Int J Epidemiol 31:240-7. 2002
    ..To estimate the distribution of blood pressure (BP), body mass index (BMI), smoking habits and their associations with socioeconomic status (SES) in an urban population in early epidemiological transition...
  97. pmc A tool box for operational mosquito larval control: preliminary results and early lessons from the Urban Malaria Control Programme in Dar es Salaam, Tanzania
    Ulrike Fillinger
    Durham University, School of Biological and Biomedical Sciences, South Road, Durham DH13LE, UK
    Malar J 7:20. 2008
    ..As the population of Africa rapidly urbanizes, large populations could be protected from malaria by controlling aquatic stages of mosquitoes if cost-effective and scalable implementation systems can be designed...
  98. doi Evaluation of self-care practices and emotional distress among people with Type 2 diabetes mellitus in Dar es Salaam, Tanzania
    Theobald C E Mosha
    Department of Food Science and Nutrition, Sokoine University of Agriculture, Morogoro, Tanzania
    Ecol Food Nutr 48:89-111. 2009
    ..determine self-care practices and diabetes related emotional distress among people with Type 2 diabetes mellitus in Dar es Salaam, Tanzania...
  99. ncbi Bacteria isolated from bloodstream infections at a tertiary hospital in Dar es Salaam, Tanzania--antimicrobial resistance of isolates
    S Moyo
    Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
    S Afr Med J 100:835-8. 2010
    A bloodstream infection (BSI) is a life-threatening condition. We studied the causative agents of BSIs and antimicrobial susceptibility patterns of bacterial isolates at Muhimbili National Hospital (MNH) in Dar es Salaam, Tanzania.
  100. doi Sodium-calcium exchanger and lipid rafts in pig coronary artery smooth muscle
    Iwona Kuszczak
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Biochim Biophys Acta 1808:589-96. 2011
    ..smooth muscle expresses, among many other proteins, Na+-Ca²+-exchanger NCX1 and sarcoplasmic reticulum Ca²+ pump SERCA2. NCX1 has been proposed to play a role in refilling the sarcoplasmic reticulum Ca²+ pool suggesting a functional ..

Research Grants119 found, 100 shown here

  1. Malaria in Pregnancy: Nutrition and Immunologic Effects
    Wafaie W Fawzi; Fiscal Year: 2010
    ..out by Harvard School of Public Health in collaboration with Muhimbili University of Health and Allied Sciences in Dar es Salaam, Tanzania...
  2. Effects of protein-calorie supplementation on HIV disease in breastfeeding women
    C von Reyn; Fiscal Year: 2009
    ..of Health and Allied Sciences in Tanzania we will conduct 3 nutritional studies among HIV-infected women in Dar es Salaam...
  3. Effects of protein-calorie supplementation on HIV disease in breastfeeding women
    C Fordham von Reyn; Fiscal Year: 2010
    ..of Health and Allied Sciences in Tanzania we will conduct 3 nutritional studies among HIV-infected women in Dar es Salaam...
  4. Partnership on Nutrition and HIV/AIDS Research in Tanza*
    Wafaie Fawzi; Fiscal Year: 2006
    ..The program will be carried out as a collaborative effort between Muhimbili University College of Health Sciences, Dar-es-Salaam, Tanzania and the Harvard School of Public Health, Boston, MA.
  5. Harvard Tanzania HIV/AIDS Clinical Trials Unit
    Wafaie Fawzi; Fiscal Year: 2007
    ..partners at two Clinical Research Sites (CRS), namely Muhimbili University College of Health Sciences (MUCHS) in Dar es Salaam and Kilimanjaro Christian Medical Center (KCMC) in Moshi...
  6. NUTRITION, IMMUNOLOGY, AND EPIDEMIOLOGY OF TB
    Wafaie Fawzi; Fiscal Year: 2004
    ..e. for a total of 20 months). Consenting subjects who present to 2 TB clinics in Dar es Salaam seeking care for respiratory illness will be screened for TB and HIV infection and invited to participate ..
  7. HIV PREVENTION TRIALS UNIT
    Wafaie Fawzi; Fiscal Year: 2004
    Harvard University (Boston, MA) and Muhmbili University (Dar es Salaam, Tanzania) have been involved in collaborative research for over 2 decades...
  8. DISSEMINATED TUBERCULOSIS IN HIV INFECTION
    C von Reyn; Fiscal Year: 2007
    ..We established laboratories and clinical facilities in Dar es Salaam, Tanzania, trained study personnel and developed referral relationships with 22 HIV testing centers...
  9. The effect of ART on sexual risk behavior in Chennai, India
    Caitlin Kennedy; Fiscal Year: 2007
    ..This study examines the effect of ART on sexual risk behavior among HIV-positive individuals in Dar es Salaam, Tanzania...
  10. Feasibility study of LGG in HIV-exposed, breastfeeding infants in Tanzania.
    Ruth Connor; Fiscal Year: 2007
    ..This study will be conducted in Dar es Salaam, Tanzania in collaboration with Muhimbili University College of Health Sciences...
  11. Four-Arm RCT of Brief MI vs. Couples-Based HIV/STI Prevention in South Africa
    William W Latimer; Fiscal Year: 2010
    ..In Dar es Salaam, Tanzania, recent studies suggest that the estimated prevalence of 12,000 injection drug users is rapidly ..
  12. Tanzania Injection Drug Use/HIV Prevention Project
    Mark Williams; Fiscal Year: 2006
    ..TAPP builds on research we have been conducting for the past two years in Dar es Salaam, Tanzania...
  13. Cardiac Sarcoplasmic Reticulum Calcium Cycling Proteins
    Evangelia G Kranias; Fiscal Year: 2010
    ..Our previous studies showed that dephosphorylated phospholamban inhibits the SERCA2 Ca-affinity and it represents a fundamental "brake" mechanism in SR Ca-cycling and cardiac contractility...
  14. Calcium Handling in Cardiac Pathophysiology
    Evangelia Kranias; Fiscal Year: 2009
    ..Our previous studies showed that phospholamban interacts with SERCA2 and inhibits its Ca-affinity, representing a fundamental "brake" in SR Ca-cycling and cardiac contractility...
  15. Calcium Handling in Cardiac Pathophysiology
    Evangelia G Kranias; Fiscal Year: 2010
    ..Our previous studies showed that phospholamban interacts with SERCA2 and inhibits its Ca-affinity, representing a fundamental "brake" in SR Ca-cycling and cardiac contractility...
  16. Abnormal Intracellular Calcium Release in Heart Failure
    Sandor Gyorke; Fiscal Year: 2007
    ..questions that will be addressed in this research proposal include: 1) What are the relative roles of altered SERCA2-mediated uptake, reduced NCX removal and enhanced SR Ca leak in altered Ca handling; 2) Can the defective Ca ..
  17. Abnormal Intracellular Calcium Release in Heart Failure
    Sandor Gyorke; Fiscal Year: 2010
    ..questions that will be addressed in this research proposal include: 1) What are the relative roles of altered SERCA2-mediated uptake, reduced NCX removal and enhanced SR Ca leak in altered Ca handling;2) Can the defective Ca ..
  18. Abnormal Intracellular Calcium Release in Heart Failure
    Sandor Gyorke; Fiscal Year: 2009
    ..questions that will be addressed in this research proposal include: 1) What are the relative roles of altered SERCA2-mediated uptake, reduced NCX removal and enhanced SR Ca leak in altered Ca handling; 2) Can the defective Ca ..
  19. Oxidative Stress in Myocardial Remodeling and Failure
    Wilson S Colucci; Fiscal Year: 2010
    ..contractile dysfunction, which is due in part to reduced activity of sarcoplasmic reticulum calcium ATPase 2 (SERCA2)...
  20. Oxidative Stress in Myocardial Remodeling and Failure
    Wilson Colucci; Fiscal Year: 2009
    ..contractile dysfunction, which is due in part to reduced activity of sarcoplasmic reticulum calcium ATPase 2 (SERCA2)...
  21. Prolactin as a Growth Factor in Breast Cancer
    Nira Ben Jonathan; Fiscal Year: 2010
    ..We discovered expression of dopamine receptors (DAR) in breast tissue, adipocytes and BCC...
  22. Dynamic and Static Autoregulation Impairment in the Optic Nerve Head of Glaucoma
    Lin Wang; Fiscal Year: 2010
    ..in the normal ONH initiated by an ocular perfusion pressure change contains two phases: an initial dynamic phase (dAR) when vascular smooth muscles dilate and contract to adjust the vascular resistance in an attempt to return blood ..
  23. Central and Peripheral Elements of Respiratory Pattern Formation
    DONALD MC CRIMMON; Fiscal Year: 2009
    ..Three Specific Aims will be addressed. In Aim 1 the axonal projections of the different types of SAR and DAR NTS relay neurons will be comprehensively surveyed using anterograde labeling of small groups of NTS cells combined ..
  24. Central and Peripheral Elements of Respiratory Pattern Formation
    DONALD R MC CRIMMON; Fiscal Year: 2010
    ..Three Specific Aims will be addressed. In Aim 1 the axonal projections of the different types of SAR and DAR NTS relay neurons will be comprehensively surveyed using anterograde labeling of small groups of NTS cells combined ..
  25. Thyroid Hormone Receptor Function in Cardiac Hypertrophy
    Kaie Ojamaa; Fiscal Year: 2006
    ..binding isoform, TR alpha 2,has the unique ability to repress T3-inducible transcription of cardiac alpha-MHC and SERCA2 genes...
  26. DIABETIC CARDIOMYOPATHY AND CALCIUM FLUX
    Wolfgang Dillmann; Fiscal Year: 2003
    ..handling and explore mechanisms leading to decreased levels of the calcium ATPase of the sarcoplasmic reticulum (SERCA2) and changes in the ryanodine receptors (RyR2)...
  27. Redox Regulation of SERCA by Nitric Oxide
    Richard A Cohen; Fiscal Year: 2010
    ..SERCA C674, 2) a sequence-specific antibody that recognizes irreversibly oxidized SERCA C674, and 3) heterozygote SERCA2 C674S knock-in (SKI+/-) mice that preliminary studies show have abnormal 7NO-stimulated SERCA activity and ..
  28. TRANSGENIC MODELS OF RESPIRATORY CONTROL
    David Millhorn; Fiscal Year: 2002
    ..We further hypothesize that calcium pumps (SERCA2, SERCA3 and PMCA2) play a major role in regulating the level of cytosolic Ca2+ during hypoxia...
  29. Cardiac Sarcoplasmic Reticulum Calcium Cycling Proteins
    Evangelia Kranias; Fiscal Year: 2007
    ..The main SR proteins responsible for these functions are: the Ca-transport ATPase (SERCA2) with its regulator phospholamban (PLN); the Ca-storage proteins, calsequestrin and a histidine rich Ca-binding ..
  30. Cardiac Sarcoplasmic Reticulum Calcium Cycling Proteins
    Evangelia Kranias; Fiscal Year: 2009
    ..The main SR proteins responsible for these functions are: the Ca-transport ATPase (SERCA2) with its regulator phospholamban (PLN); the Ca-storage proteins, calsequestrin and a histidine rich Ca-binding ..