SERCA2

Summary

Gene Symbol: SERCA2
Description: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
Alias: ATP2B, DAR, SERCA2, sarcoplasmic/endoplasmic reticulum calcium ATPase 2, ATPase Ca++ transporting cardiac muscle slow twitch 2, ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2, SR Ca(2+)-ATPase 2, calcium pump 2, calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, cardiac Ca2+ ATPase, endoplasmic reticulum class 1/2 Ca(2+) ATPase
Species: human
Products:     SERCA2

Top Publications

  1. Kuo T, Kim H, Zhu L, Yu Y, Lin H, Tsang W. Modulation of endoplasmic reticulum calcium pump by Bcl-2. Oncogene. 1998;17:1903-10 pubmed
    ..The steady state levels of SERCA2 mRNA and protein were both increased in Bcl-2 expression clones...
  2. Sakuntabhai A, Ruiz Perez V, Carter S, Jacobsen N, Burge S, Monk S, et al. Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat Genet. 1999;21:271-7 pubmed
    ..mutations in the ATP2A2 gene, which encodes the sarco/endoplasmic reticulum Ca2(+)-ATPase type 2 isoform (SERCA2) and is highly expressed in keratinocytes...
  3. Sakuntabhai A, Burge S, Monk S, Hovnanian A. Spectrum of novel ATP2A2 mutations in patients with Darier's disease. Hum Mol Genet. 1999;8:1611-9 pubmed
    ..These results illustrate the considerable diversity of ATP2A2 mutations causing DD and suggest that additional factors are important contributors to the clinical phenotype. ..
  4. del MonteF -, Harding S, Schmidt U, Matsui T, Kang Z, Dec G, et al. Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a. Circulation. 1999;100:2308-11 pubmed
    ..These results support the premise that gene-based therapies and targeting of specific pathways in human heart failure may offer a new modality for the treatment of this disease. ..
  5. Asahi M, McKenna E, Kurzydlowski K, Tada M, MacLennan D. Physical interactions between phospholamban and sarco(endo)plasmic reticulum Ca2+-ATPases are dissociated by elevated Ca2+, but not by phospholamban phosphorylation, vanadate, or thapsigargin, and are enhanced by ATP. J Biol Chem. 2000;275:15034-8 pubmed
  6. Gelebart P, Martin V, Enouf J, Papp B. Identification of a new SERCA2 splice variant regulated during monocytic differentiation. Biochem Biophys Res Commun. 2003;303:676-84 pubmed
    ..We report that in addition to the ubiquitously expressed SERCA2b isoform, a new splice variant of SERCA2 can be detected (SERCA2c) that arises from the inclusion of a short intronic sequence located between exons 20 and ..
  7. Adachi T, Weisbrod R, Pimentel D, Ying J, Sharov V, SCHONEICH C, et al. S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide. Nat Med. 2004;10:1200-7 pubmed
    ..Thus, irreversible oxidation of key thiol(s) in disease impairs NO-induced relaxation by preventing reversible S-glutathiolation and activation of SERCA by NO/ONOO(-). ..
  8. Mahn K, Hirst S, Ying S, Holt M, Lavender P, Ojo O, et al. Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma. Proc Natl Acad Sci U S A. 2009;106:10775-80 pubmed publisher
    ..Compared with control cells from healthy subjects, SERCA2 mRNA and protein expression was reduced in ASM cells from subjects with moderately severe asthma...
  9. Kho C, Lee A, Jeong D, Oh J, Chaanine A, Kizana E, et al. SUMO1-dependent modulation of SERCA2a in heart failure. Nature. 2011;477:601-5 pubmed publisher
    ..Taken together, our data show that SUMOylation is a critical post-translational modification that regulates SERCA2a function, and provide a platform for the design of novel therapeutic strategies for heart failure. ..

More Information

Publications140 found, 100 shown here

  1. Dodiuk Gad R, Cohen Barak E, Khayat M, Milo H, Amariglio Diskin L, Danial Faran N, et al. Darier disease in Israel: combined evaluation of genetic and neuropsychiatric aspects. Br J Dermatol. 2016;174:562-8 pubmed publisher
    ..Although no clear genotype-phenotype correlation was found, the results point to a major effect of genetic background on psychiatric phenotype, together with other modifiers. ..
  2. Pettit C, Ulman C, Spohn G, Kaffenberger J. A case of segmental Darier disease treated with doxycycline monotherapy. Dermatol Online J. 2018;24: pubmed
    ..results from a mutation in the gene coding for the endoplasmic reticulum membrane calcium pump Ca2+-ATPase type 2 (SERCA2), leading to compromised intercellular adhesion...
  3. Harboe T, Willems P, Jespersgaard C, Mølgaard Poulsen M, Sørensen F, Bisgaard M. Mosaicism in segmental Darier disease: an in-depth molecular analysis quantifying proportions of mutated alleles in various tissues. Dermatology. 2011;222:292-6 pubmed publisher
    ..We further recommend molecular analysis of the ATP2A2 gene in semen of male patients with segmental Darier disease to improve genetic counseling. ..
  4. Strausburg M, Linos K, Staser K, Mousdicas N. Dowling-Degos disease co-presenting with Darier disease. Clin Exp Dermatol. 2016;41:410-2 pubmed publisher
    ..In this case, the patient presented with features of both DDD and DD, which suggests that either a cooperating mutation or a mutation in an unrelated gene locus may underlie the findings in this patient. ..
  5. Uche Holub E, Ritter M, Helbig D, Stege H, Frank J. [Segmental type 1 manifestation of Darier disease. An example of cutaneous mosaicism]. Hautarzt. 2012;63:759-62 pubmed publisher
    ..The type 1 segmental manifestation reflects a de novo postzygotic somatic mutation in the heterozygous state and as a rule can be found in all autosomal dominantly inherited genodermatoses. ..
  6. Takagi A, Kamijo M, Ikeda S. Darier disease. J Dermatol. 2016;43:275-9 pubmed publisher
    ..of ATP2A2, which encodes an endoplasmic reticulum calcium pump, sarco/endoplasmic reticulum ATPase type 2 (SERCA2)...
  7. Morin C, Netchiporouk E, Billick R, Srolovitz H, Roshdy O. Hypopigmented segmental Darier disease. J Cutan Med Surg. 2015;19:69-72 pubmed publisher
    ..To our knowledge, this is the first case reporting a combined segmental and hypopigmented variant of Darier disease. We further present a literature review for hypopigmented and segmental variants of Darier disease. ..
  8. Knopp E, Saraceni C, Moss J, McNiff J, Choate K. Somatic ATP2A2 mutation in a case of papular acantholytic dyskeratosis: mosaic Darier disease. J Cutan Pathol. 2015;42:853-7 pubmed publisher
    ..These findings establish somatic mosaicism of ATP2A2 mutations as a genetic cause for papular acantholytic dyskeratosis. ..
  9. Cederlöf M, Karlsson R, Larsson H, Almqvist C, Magnusson P, Nordlind K, et al. Intellectual disability and cognitive ability in Darier disease: Swedish nation-wide study. Br J Dermatol. 2015;173:155-8 pubmed publisher
    ..The Darier-causing mutations merit further attention in molecular genetic research on intellectual disability and cognitive ability. ..
  10. Sahraoui A, Dewachter C, de Medina G, Naeije R, Aouichat Bouguerra S, Dewachter L. Myocardial Structural and Biological Anomalies Induced by High Fat Diet in Psammomys obesus Gerbils. PLoS ONE. 2016;11:e0148117 pubmed publisher
    ..Myocardial expressions of sarco(endo)plasmic calcium-ATPase (SERCA2) and voltage-dependent calcium channel (Cacna1c) decreased, while protein kinase A (PKA) and calcium-calmodulin-..
  11. Hamlyn J, Linde C, Gao J, Huang B, Golovina V, Blaustein M, et al. Neuroendocrine humoral and vascular components in the pressor pathway for brain angiotensin II: a new axis in long term blood pressure control. PLoS ONE. 2014;9:e108916 pubmed publisher
    ..the type 6 canonical transient receptor potential protein (TRPC6), and the sarcoplasmic reticulum calcium ATPase (SERCA2). Wistar rats received a chronic intra-cerebroventricular infusion of vehicle (C) or Ang II (A, 2...
  12. Warbrick I, Rabkin S. Effect of the peptides Relaxin, Neuregulin, Ghrelin and Glucagon-like peptide-1, on cardiomyocyte factors involved in the molecular mechanisms leading to diastolic dysfunction and/or heart failure with preserved ejection fraction. Peptides. 2019;111:33-41 pubmed publisher
    ..Neuregulin-1, an epidermal growth factor, induces nitric oxide and PI-3 kinase activation that enhance SERCA2 activity...
  13. Zup S, Edwards N, McCarthy M. Sex- and age-dependent effects of androgens on glutamate-induced cell death and intracellular calcium regulation in the developing hippocampus. Neuroscience. 2014;281:77-87 pubmed publisher
    ..calcium ATPase1 (PMCA1), sodium/calcium exchanger1 (NCX1), and the sarco/endoplasmic reticulum calcium ATPase 2 (SERCA2). Surprisingly, there was no sex difference in the level of any of the three proteins...
  14. Hamilton D, Zhang A, Li S, Cao T, Smith J, Vedula I, et al. Combination of angiotensin II and l-NG-nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure. Am J Physiol Heart Circ Physiol. 2016;310:H667-80 pubmed publisher
    ..We conclude that l-NAME + AngII is associated with impaired mitochondrial respiratory function and increased oxidative stress compared with either l-NAME or AngII alone, resulting in nonischemic HF. ..
  15. Jia Y, Chang H, Schipma M, Liu J, Shete V, Liu N, et al. Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice. PLoS ONE. 2016;11:e0160755 pubmed publisher
  16. Robinson P, Liu X, Sparrow A, Patel S, Zhang Y, Casadei B, et al. Hypertrophic cardiomyopathy mutations increase myofilament Ca2+ buffering, alter intracellular Ca2+ handling, and stimulate Ca2+-dependent signaling. J Biol Chem. 2018;293:10487-10499 pubmed publisher
    ..activity, sarcoplasmic reticulum Ca2+ load, and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) activity driven by Ca2+/calmodulin-dependent protein kinase II (CaMKII) phosphorylation of ..
  17. Tripathi S, Kumar P, Trabulsi E, Kim S, McCue P, Intenzo C, et al. VPAC1 Targeted 64Cu-TP3805 kit preparation and its evaluation. Nucl Med Biol. 2017;51:55-61 pubmed publisher
    ..Specificity of 64Cu-TP3805 for VPAC1 was examined with digital autoradiography (DAR) of prostate tissues obtained after prostatectomy, benign prostatic hyperplasia (BPH) tissue, and benign and ..
  18. James R, Walter I, Seebacher F. Variation in expression of calcium-handling proteins is associated with inter-individual differences in mechanical performance of rat (Rattus norvegicus) skeletal muscle. J Exp Biol. 2011;214:3542-8 pubmed publisher
    ..reticulum calcium ATPase (SERCA)1 protein concentration, total SERCA activity, and mRNA concentrations of SERCA1, SERCA2, troponin I and ryanodine receptors...
  19. Kunert Keil C, Gredes T, Lucke S, Botzenhart U, Dominiak M, Gedrange T. Differential expression of genes involved in the calcium homeostasis in masticatory muscles of MDX mice. J Physiol Pharmacol. 2014;65:317-24 pubmed
    ..of this study was to examine the mRNA and protein levels of the sarcoplasmic reticulum Ca(2+) ATPases SERCA1 and SERCA2, the plasma membrane Ca(2+) ATPases Atp2b1 and Atp2b4, the sodium/calcium exchanger NCX1, the ryanodine receptor 1,..
  20. Kilale A, Kimaro G, Kahwa A, Chilagwile M, Ngowi B, Muller W, et al. High prevalence of tuberculosis diagnosed during autopsy examination at Muhimbili National Hospital in Dar es Salaam, Tanzania. Tanzan J Health Res. 2013;15:171-7 pubmed
    ..There is a need for increased awareness and to include post-mortem data in the annual statistics of TB for precise reporting of the magnitude of the TB burden in the country. ..
  21. Xu S, Ying J, Jiang B, Guo W, Adachi T, Sharov V, et al. Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging. Am J Physiol Heart Circ Physiol. 2006;290:H2220-7 pubmed
    ..known nY sites in MnSOD nY-34 and of two adjacent nY in the sarcoplasmic endoplasmic reticulum calcium ATPase (SERCA2 di-nY-294,295) were developed...
  22. Han S, Bal N, Sadi G, Usanmaz S, Uludag M, Demirel Yilmaz E. The effects of LXR agonist GW3965 on vascular reactivity and inflammation in hypertensive rat aorta. Life Sci. 2018;213:287-293 pubmed publisher
    ..Decreased sarco/endoplasmic reticulum Ca2+-ATPase2 (SERCA2) expression in the hypertensive aorta was not changed by GW3965 treatment...
  23. Dong Q, Wu Z, Li X, Yan J, Zhao L, Yang C, et al. Resveratrol ameliorates cardiac dysfunction induced by pressure overload in rats via structural protection and modulation of Ca(2+) cycling proteins. J Transl Med. 2014;12:323 pubmed publisher
    ..handling proteins induced by aortic banding, including downregulation of sarcoplasmic reticulum Ca(2+) ATPase 2 (SERCA2) and ryanodine receptor 2 (RyR2), hypophosphorylated phospholamban (PLB), upregulation of Na(+)/Ca(2+)-exchangers (..
  24. Zhao F, Fu L, Yang W, Dong Y, Yang J, Sun S, et al. Cardioprotective effects of baicalein on heart failure via modulation of Ca(2+) handling proteins in vivo and in vitro. Life Sci. 2016;145:213-23 pubmed publisher
    ..CaMKII) and expression of Na(+)/Ca(2+)-exchangers (NCX1), upregulation of sarcoplasmic reticulum Ca(2+) ATPase 2 (SERCA2) and ryanodine receptor 2 (RYR2). Baicalein also restrained the decreased SERCA activity induced by aortic banding...
  25. Petter da Silva F, Beatriz Dallepiane L, Ramos Kirsten V, Maria Kirchner R. [Not Available]. Nutr Hosp. 2016;33:37-42 pubmed publisher
    ..Una ingesta inadecuada de nutrientes puede dar lugar a deficiencias nutricionales y, por lo tanto, a cambios fisiológicos y patológicos que pondrían en peligro ..
  26. Eilers W, Jaspers R, de Haan A, Ferrié C, Valdivieso P, Flück M. CaMKII content affects contractile, but not mitochondrial, characteristics in regenerating skeletal muscle. BMC Physiol. 2014;14:7 pubmed publisher
    ..activity accelerated excitation-contraction coupling and relaxation in SOL muscle in association with increased SERCA2, ANXV and fast myosin type IIA/X content but did not affect mitochondrial protein content...
  27. Bárez López S, Hartley M, Grijota Martinez C, Scanlan T, Guadaño Ferraz A. Sobetirome and its amide prodrug Sob-AM2 exert thyromimetic actions in Mct8-deficient brain. Thyroid. 2018;: pubmed publisher
    ..Therefore, sobetirome and Sob-AM2 have the potential to address the cerebral hypothyroidism and the peripheral hyperthyroidism characteristic of MCT8 deficiency. ..
  28. Kang S, Dahl R, Hsieh W, Shin A, Zsebo K, Buettner C, et al. Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders. J Biol Chem. 2016;291:5185-98 pubmed publisher
    ..ER stress response and ER stress-induced apoptosis, and improved mitochondrial biogenesis, possibly through SERCA2-mediated activation of AMP-activated protein kinase pathway...
  29. Nombo A, Mwanri A, Brouwer Brolsma E, Ramaiya K, Feskens E. Gestational diabetes mellitus risk score: A practical tool to predict gestational diabetes mellitus risk in Tanzania. Diabetes Res Clin Pract. 2018;145:130-137 pubmed publisher
    ..We used cross-sectional data of 609 pregnant women, without known diabetes, collected in six health facilities from Dar es Salaam city (urban). Women underwent screening for GDM during ante-natal clinics visit...
  30. Wang L, Li W, Yang Y, Hu Y, Gu Y, Shu Y, et al. High expression of sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase 2b blocks cell differentiation in human liposarcoma cells. Life Sci. 2014;99:37-43 pubmed publisher
    We have previously reported that elevated expression of sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase 2 (SERCA2) was related to the malignant degree of different types of human liposarcoma...
  31. Kidantou H, Mwampagatwa I, van Roosmalen J. Uterine rupture: a retrospective analysis of causes, complications and management outcomes at Muhimbili National Hospital in Dar es Salaam, Tanzania. Tanzan J Health Res. 2012;14:220-5 pubmed
    ..and foetal/maternal outcome among women with a diagnosis of ruptured uterus at Muhimbili National Hospital (MNH) in Dar es Salaam Tanzania...
  32. Celli A, Mackenzie D, Zhai Y, Tu C, Bikle D, Holleran W, et al. SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease. J Invest Dermatol. 2012;132:1188-95 pubmed publisher
    ..levels increase and sphingosine kinase (SPHK1) expression decreases after inactivating SERCA2b with the specific SERCA2 inhibitors thapsigargin (TG) or small interfering RNA to SERCA2b...
  33. Huapaya J, Chávez Trujillo K, Trelles M, Dueñas Carbajal R, Ferrandiz Espadin R. Anatomic variations of the branches of the aortic arch in a Peruvian population. Medwave. 2015;15:e6194 pubmed publisher
    ..Sur encontraron una variante anatómica que no había sido reportada en el resto del mundo, lo que podría dar indicios acerca de una diferencia racial...
  34. Shaikh S, Sahoo S, Periasamy M. Phospholamban and sarcolipin: Are they functionally redundant or distinct regulators of the Sarco(Endo)Plasmic Reticulum Calcium ATPase?. J Mol Cell Cardiol. 2016;91:81-91 pubmed publisher
    ..We will also explore whether structural differences in the cytosolic domain of PLB and SLN are the basis for their unique function and physiological roles in cardiac and skeletal muscle. ..
  35. Thomson R, Johanes B, Festo C, Kalolella A, Taylor M, Tougher S, et al. An assessment of the malaria-related knowledge and practices of Tanzania's drug retailers: exploring the impact of drug store accreditation. BMC Health Serv Res. 2018;18:169 pubmed publisher
    ..We compare ADDO and non-ADDO regions, excluding the largest city, Dar es Salaam, due to the unique characteristics of its market...
  36. Wootton L, Michelangeli F. The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors. J Biol Chem. 2006;281:6970-6 pubmed
  37. Pani B, Cornatzer E, Cornatzer W, Shin D, Pittelkow M, Hovnanian A, et al. Up-regulation of transient receptor potential canonical 1 (TRPC1) following sarco(endo)plasmic reticulum Ca2+ ATPase 2 gene silencing promotes cell survival: a potential role for TRPC1 in Darier's disease. Mol Biol Cell. 2006;17:4446-58 pubmed
    ..Similar up-regulation of TRPC1 was also detected in epidermal layers of SERCA2+/- mice. HaCaT cells expressed TRPC1 in the plasma membrane...
  38. Yimer M, Hailu T, Mulu W, Abera B, Ayalew W. A 5 year trend analysis of malaria prevalence with in the catchment areas of Felegehiwot referral Hospital, Bahir Dar city, northwest-Ethiopia: a retrospective study. BMC Res Notes. 2017;10:239 pubmed publisher
    ..02) and males (p < 0.025) were significantly affected. In conclusion, P. falciparum was predominant as compared to P. vivax. Hence, it needs close monitoring and intervention measures for control activities. ..
  39. Said K, Hella J, Knopp S, Nassoro T, Shija N, Aziz F, et al. Schistosoma, other helminth infections, and associated risk factors in preschool-aged children in urban Tanzania. PLoS Negl Trop Dis. 2017;11:e0006017 pubmed publisher
    ..We assessed the prevalence of helminth infections and determined risk factors for infection among preschool-aged children in the urban setting of Dar es Salaam, Tanzania.
  40. Donthamsetti P, Winter N, Schönberger M, Levitz J, Stanley C, Javitch J, et al. Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist. J Am Chem Soc. 2017;139:18522-18535 pubmed publisher
    ..Using an azobenzene derivative of the well-known DAR ligand 2-(N-phenethyl-N-propyl)amino-5-hydroxytetralin (PPHT), we were able to rapidly, reversibly, and selectively ..
  41. Hassan A, Kotb M, Awadallah A, Wahba A, Shehata N. Follicular output rate can predict clinical pregnancy in women with unexplained infertility undergoing IVF/ICSI: a prospective cohort study. Reprod Biomed Online. 2017;34:598-604 pubmed publisher
    ..This was a prospective study conducted at Dar El Teb subfertility centre in Cairo between June 2014 and July 2016...
  42. Rodríguez Jareño M, De Montserrat I Nonó J. [Is it possible to improve the preventive usefulness of workers' health surveillance in the current regulatory framework?]. Arch Prev Riesgos Labor. 2017;20:80-101 pubmed publisher
    ..Los exámenes de salud indiscriminados e inespecíficos para dar aparente cumplimiento a las obligaciones empresariales mediante un “listado de aptitudes” determinan la baja ..
  43. Crepin A, Bidaux G, Vanden Abeele F, Dewailly E, Goffin V, Prevarskaya N, et al. Prolactin stimulates prostate cell proliferation by increasing endoplasmic reticulum content due to SERCA 2b over-expression. Biochem J. 2007;401:49-55 pubmed
    ..A small inter-fering RNA SERCA 2a/b, used to down-regulate endogenous SERCA 2b expression, reduced both PNT1A cell proliferation and [Ca2+]ER. We thus identify [Ca2+]ER and SERCA 2b as protagonists in PRL-induced proliferation. ..
  44. Govella N, Ogoma S, Paliga J, Chaki P, Killeen G. Impregnating hessian strips with the volatile pyrethroid transfluthrin prevents outdoor exposure to vectors of malaria and lymphatic filariasis in urban Dar es Salaam, Tanzania. Parasit Vectors. 2015;8:322 pubmed publisher
    ..strips were placed around human volunteers conducting human landing catch in an outdoor environment in urban Dar es Salaam, where much human exposure to malaria and filariasis transmission occurs outdoors...
  45. Abioye A, Aboud S, Premji Z, Etheredge A, Gunaratna N, Sudfeld C, et al. Iron Supplementation Affects Hematologic Biomarker Concentrations and Pregnancy Outcomes among Iron-Deficient Tanzanian Women. J Nutr. 2016;146:1162-71 pubmed publisher
    ..600 iron-deficient (serum ferritin ?12 ?g/L) pregnant women, aged 18-45 y, presenting to 2 antenatal clinics in Dar es Salaam, Tanzania using rapid ferritin screening tests, and prospectively followed them through delivery and ..
  46. Tong X, Kono T, Anderson Baucum E, Yamamoto W, Gilon P, Lebeche D, et al. SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity. Diabetes. 2016;65:3039-52 pubmed publisher
    The sarcoendoplasmic reticulum (ER) Ca(2+) ATPase 2 (SERCA2) pump is a P-type ATPase tasked with the maintenance of ER Ca(2+) stores...
  47. Santos Alarcón S, Sanchis Sanchez C, Mateu Puchades A. Diclofenac sodium 3% gel for darier's disease treatment. Dermatol Online J. 2016;22: pubmed
    ..We did not observed topical adverse effects, neither systemic absorption symptoms, but werecognized further and larger studies are needed to asses the efficacy and safety of this treatment in DD. ..
  48. Ruan J, Tulloch N, Razumova M, Saiget M, Muskheli V, Pabon L, et al. Mechanical Stress Conditioning and Electrical Stimulation Promote Contractility and Force Maturation of Induced Pluripotent Stem Cell-Derived Human Cardiac Tissue. Circulation. 2016;134:1557-1567 pubmed
    ..Stress conditioning also increased SERCA2 (Sarco/Endoplasmic Reticulum Calcium ATPase 2) expression, which correlated with a less negative force-frequency ..
  49. KatipoÄŸlu N, Karapinar T, Demir K, Aydin Köker S, NalbantoÄŸlu Ã, Ay Y, et al. Infantile-onset thiamine responsive megaloblastic anemia syndrome with SLC19A2 mutation: a case report. Arch Argent Pediatr. 2017;115:e153-e156 pubmed publisher
    ..Se les debe dar seguimiento para determinar la respuesta de la enfermedad hematológica y de la diabetes después de la terapia ..
  50. Abera B, Mohammed B, Betela W, Yimam R, Oljira A, Ahmed M, et al. Knowledge, attitude, and practice towards blood donation among health care providers in hospitals at Bahir Dar City, Ethiopia. Transfus Apher Sci. 2017;56:434-438 pubmed publisher
    ..to determine the knowledge, attitude and practice towards blood donation among health care providers in Bahir Dar City, Ethiopia. Paper based questionnaire was distributed to 276 health care providers from May 01 to June 30, 2016...
  51. Muhihi A, Njelekela M, Mpembeni R, Muhihi B, Anaeli A, Chillo O, et al. Elevated blood pressure among primary school children in Dar es salaam, Tanzania: prevalence and risk factors. BMC Pediatr. 2018;18:54 pubmed publisher
    ..blood pressure profiles and risk factors associated with elevated blood pressure among primary school children in Dar es Salaam, Tanzania...
  52. Zhang J, Li Y, Jiang S, Yu H, An W. Enhanced endoplasmic reticulum SERCA activity by overexpression of hepatic stimulator substance gene prevents hepatic cells from ER stress-induced apoptosis. Am J Physiol Cell Physiol. 2014;306:C279-90 pubmed publisher
    ..In conclusion, the protective effect of HSS against ER stress may be associated with the removal of ROS to restore the activity of the SERCA. ..
  53. Hayward C, Patel H, Lyon A. Gene therapy in heart failure. SERCA2a as a therapeutic target. Circ J. 2014;78:2577-87 pubmed
    ..We discuss the laboratory and early clinical evidence for the benefit of SERCA2a gene therapy in HF. Finally, we discuss the ongoing clinical trials of SERCA2a gene therapy and possible future directions for this treatment. ..
  54. Dogan D, Kutluturk Y, Kivilcim M, Canaloglu S. Communication skills of residents to families with Down syndrome babies. Arch Argent Pediatr. 2016;114:521-525 pubmed publisher
    ..En general, los pediatras son los primeros profesionales de la atención médica encargados de dar el diagnóstico inicial de síndrome de Down (SD) a las familias...
  55. Muzeyen R, Ayichiluhm M, Manyazewal T. Legal rights to safe abortion: knowledge and attitude of women in North-West Ethiopia toward the current Ethiopian abortion law. Public Health. 2017;148:129-136 pubmed publisher
    ..Women of reproductive age in three selected lower districts in Bahir Dar, North-West Ethiopia, were included...
  56. Chimhutu V, Tjomsland M, Songstad N, Mrisho M, Moland K. Introducing payment for performance in the health sector of Tanzania- the policy process. Global Health. 2015;11:38 pubmed publisher
    ..and government departments influential in the process of introducing the P4P scheme in Tanzania were conducted in Dar es Salaam, Tanzania and Oslo, Norway...
  57. Maman S, Kajula L, Balvanz P, Kilonzo M, Mulawa M, Yamanis T. Leveraging strong social ties among young men in Dar es Salaam: A pilot intervention of microfinance and peer leadership for HIV and gender-based violence prevention. Glob Public Health. 2016;11:1202-1215 pubmed
    ..We piloted a microfinance and health promotion intervention among social networks of primarily young men in Dar es Salaam...
  58. Francis J, Kakoko D, Tarimo E, Munseri P, Bakari M, Sandstrom E. Key considerations in scaling up male circumcision in Tanzania: views of the urban residents in Tanzania. Tanzan J Health Res. 2012;14:61-7 pubmed
    ..This cross sectional survey was conducted among members of the police force in Dar es Salaam Tanzania from January 2010 to July 2010...
  59. Wang X, Lenke L, Thuet E, Blanke K, Koester L, Roth M. Deformity Angular Ratio Describes the Severity of Spinal Deformity and Predicts the Risk of Neurologic Deficit in Posterior Vertebral Column Resection Surgery. Spine (Phila Pa 1976). 2016;41:1447-55 pubmed publisher
    Retrospective review of prospectively collected data. To assess the value of the deformity angular ratio (DAR, maximum Cobb measurement divided by number of vertebrae involved) in evaluating the severity of spinal deformity, and ..
  60. Yin X, Wang L, Qin G, Luo H, Liu X, Zhang F, et al. Rats with Chronic, Stable Pulmonary Hypertension Tolerate Low Dose Sevoflurane Inhalation as Well as Normal Rats Do. PLoS ONE. 2016;11:e0154154 pubmed publisher
    ..The protein levels of SERCA2, PLB and p-PLB expression was analyzed by western blot to assess their relevance in PAH...
  61. Shuai X, Meng Y, Lu Y, Su G, Tao X, Han J, et al. Relaxin-2 improves diastolic function of pressure-overloaded rats via phospholamban by activating Akt. Int J Cardiol. 2016;218:305-311 pubmed publisher
    ..Meanwhile, it increased the Ser16 and Thr17- phosphorylation levels of phospholamban (PLB). Furthermore, SERCA2 activity was enhanced in the TAC+RLN2 group more than in the TAC and TAC+GFP groups...
  62. Guo R, Zhang Y, Lin Q, Chen Z. A Channelization-Based DOA Estimation Method for Wideband Signals. Sensors (Basel). 2016;16: pubmed publisher
    ..A wideband digital array radar (DAR) using direct wideband radio frequency (RF) digitization is presented...
  63. Skovgaard C, Almquist N, Bangsbo J. The effect of repeated periods of speed endurance training on performance, running economy, and muscle adaptations. Scand J Med Sci Sports. 2018;28:381-390 pubmed publisher
    ..No changes in muscle expression of Na+ ,K+ -ATPase α1, α2 and β1, NHE1, SERCA1 and SERCA2, actin, and CaMKII were found during neither P1 nor P2...
  64. Lambdin B, Lorvick J, Mbwambo J, Rwegasha J, Hassan S, Lum P, et al. Prevalence and predictors of HCV among a cohort of opioid treatment patients in Dar es Salaam, Tanzania. Int J Drug Policy. 2017;45:64-69 pubmed publisher
    The government of Tanzania launched an opioid treatment program (OTP), using methadone, in Dar es Salaam in February of 2011...
  65. Tareke M, Addisu F, Abate A. Depression among patients attending antiretroviral treatment program in public health facilities in Bahir Dar City, Ethiopia. J Affect Disord. 2018;232:370-374 pubmed publisher
    ..depression and its influencing factors among people living with HIV/AIDS attending government institutions in Bahir Dar City, North West, Ethiopia...
  66. Suga K, Hattori H, Saito A, Akagawa K. RNA interference-mediated silencing of the syntaxin 5 gene induces Golgi fragmentation but capable of transporting vesicles. FEBS Lett. 2005;579:4226-34 pubmed
    ..These results suggest that Syx5 is required for the maintenance of the Golgi structures but may not play a major role in the transport of vesicles carrying VSVG between the ER and the Golgi compartment. ..
  67. Patel A, Ciccone O, Njau A, Shanungu S, Grollnek A, Fredrick F, et al. A pediatric epilepsy diagnostic tool for use in resource-limited settings: A pilot study. Epilepsy Behav. 2016;59:57-61 pubmed publisher
    ..questionnaire was then translated in local dialects and prospectively validated at Muhimbili National Hospital in Dar Es Salaam, Tanzania, and University Teaching Hospital in Lusaka, Zambia...
  68. Gaspardi A, Sippert E, de Macedo M, Pellegrino J, Costa F, Castilho L. Clinically relevant RHD-CE genotypes in patients with sickle cell disease and in African Brazilian donors. Blood Transfus. 2016;14:449-54 pubmed publisher
    ..8%) African Brazilian donors. The RHD and RHCE allele combinations found in the population studied were: RHD*DAR with RHCE*ceAR; RHD*weak D type 4.2.2 with RHCE*ceAR, RHD*weak D type 4.0 with RHCE*ceVS.01 and RHCE*ceVS...
  69. Zhu F, Zhang J, Feng J, Yang H. Hospital risk management of cutaneous herpes simplex virus infection. Clin Exp Dermatol. 2016;41:730-3 pubmed publisher
    ..Twice-daily treatment showed no increase in therapeutic effect but greatly increased DAR incidence. The valaciclovir dose that produced a reduction in AES was 1000 mg/day: SMD = -0.73 (95% CI -0.98 to 0...
  70. Zanetti E, Terzini M, Mossa L, Bignardi C, Costa P, Audenino A, et al. A structural numerical model for the optimization of double pelvic osteotomy in the early treatment of canine hip dysplasia. Vet Comp Orthop Traumatol. 2017;30:256-264 pubmed publisher
    ..Model outputs were: acetabular ventro-version (VV) and lateralization (L), Norberg (NA) and dorsal acetabular rim (DAR) angles, the percentage of acetabular coverage (PC), the peak bone stress, and moments required to deform the ..
  71. Davis J, Kagan M, Read J, Walles M, Hatsis P. Immunoprecipitation middle-up LC-MS for in vivo drug-to-antibody ratio determination for antibody-drug conjugates. Bioanalysis. 2017;9:1535-1549 pubmed publisher
    Drug-to-antibody ratio (DAR) determination is critical for development of antibody-drug conjugates (ADCs). This work presents a middle-up LC-MS approach for DAR analysis using prelabeled capture beads and in-house fabricated slit-plates...
  72. Jacobsen N, Franks E, Elvidge G, Jones I, McCandless F, O Donovan M, et al. Exclusion of the Darier's disease gene, ATP2A2, as a common susceptibility gene for bipolar disorder. Mol Psychiatry. 2001;6:92-7 pubmed
    ..In this study we have investigated the Darier's disease gene ATP2A2, the calcium pumping ATPase SERCA2, as a potential susceptibility gene for bipolar disorder under the hypothesis that variations in SERCA2 have ..
  73. Evangelista A, Thompson M, Weisbrod R, Pimental D, Tong X, Bolotina V, et al. Redox regulation of SERCA2 is required for vascular endothelial growth factor-induced signaling and endothelial cell migration. Antioxid Redox Signal. 2012;17:1099-108 pubmed publisher
    ..or (•)NO stimulated endoplasmic reticulum (ER) (45)Ca(2+) uptake, a measure of SERCA activity, and knockdown of SERCA2 prevented VEGF-induced EC migration and (45)Ca(2+) uptake...
  74. Aragaw A, Yigzaw T, Tetemke D, G Amlak W. Cultural Competence among Maternal Healthcare Providers in Bahir Dar City Administration, Northwest Ethiopia: Cross sectional Study. BMC Pregnancy Childbirth. 2015;15:227 pubmed publisher
    ..determine the level of cultural competence and its associated factors among maternal health care providers in Bahir Dar City Administration, Northwest Ethiopia...
  75. Ubuguyu O, Tran O, Bruce R, Masao F, Nyandindi C, Sabuni N, et al. Improvements in health-related quality of life among methadone maintenance clients in Dar es Salaam, Tanzania. Int J Drug Policy. 2016;30:74-81 pubmed publisher
    Injection of heroin has become widespread in Dar es Salaam, Tanzania and is spreading throughout the country...
  76. Govella N, Maliti D, Mlwale A, Masallu J, Mirzai N, Johnson P, et al. An improved mosquito electrocuting trap that safely reproduces epidemiologically relevant metrics of mosquito human-feeding behaviours as determined by human landing catch. Malar J. 2016;15:465 pubmed publisher
    ..mosquito electrocuting grid trap (MET) as a safer alternative with HLC for measuring malaria vector behaviour in Dar es Salaam, Tanzania...
  77. Asahi M, Green N, Kurzydlowski K, Tada M, MacLennan D. Phospholamban domain IB forms an interaction site with the loop between transmembrane helices M6 and M7 of sarco(endo)plasmic reticulum Ca2+ ATPases. Proc Natl Acad Sci U S A. 2001;98:10061-6 pubmed
    ..These results suggest that a SERCA1-PLN interaction site occurs between L67 of SERCA1a and domain IB of PLN, which involves SERCA1a D813 and PLN N27 and N30. ..
  78. Pereira C, Ford R, Feeley A, Sweet L, Badham J, Zehner E. Cross-sectional survey shows that follow-up formula and growing-up milks are labelled similarly to infant formula in four low and middle income countries. Matern Child Nutr. 2016;12 Suppl 2:91-105 pubmed publisher
    ..by the same company, sold in Phnom Penh, Cambodia; Kathmandu Valley, Nepal; Dakar Department, Senegal; and Dar es Salaam, Tanzania. All products were imported...
  79. Toyofuku T, Curotto Kurzydlowski K, Narayanan N, MacLennan D. Identification of Ser38 as the site in cardiac sarcoplasmic reticulum Ca(2+)-ATPase that is phosphorylated by Ca2+/calmodulin-dependent protein kinase. J Biol Chem. 1994;269:26492-6 pubmed
    ..1993) J. Biol. Chem. 268, 8394-8397), the Ca(2+)-ATPase of cardiac muscle sarcoplasmic reticulum (SERCA2) was shown to be phosphorylated by Ca2+/calmodulin-dependent protein kinase II (CaM kinase) on a serine residue, ..
  80. Godic A, Glavac D, Korosec B, Miljkovic J, Potocnik M, Kansky A. P160L mutation in the Ca(2+) ATPase 2A domain in a patient with severe Darier disease. Dermatology. 2004;209:142-4 pubmed
    ..is caused by mutations of the ATP2A2 gene, which encodes the sarco/endoplasmic reticulum Ca(2+)-ATPase isoform 2 (SERCA2). The mutations affect protein expression, degradation and activity...
  81. Pavlovic M, Schaller A, Pfammatter J, Carrel T, Berdat P, Gallati S. Age-dependent suppression of SERCA2a mRNA in pediatric atrial myocardium. Biochem Biophys Res Commun. 2005;326:344-8 pubmed
    ..Age itself did not influence the SERCA2a and PLB expression, if the hemodynamic overload was not taken into account. This study is the first to show a combined influence of volume overload and age on atrial SERCA2a expression. ..
  82. Tuusa J, Markkanen P, Apaja P, Hakalahti A, Petäjä Repo U. The endoplasmic reticulum Ca2+-pump SERCA2b interacts with G protein-coupled receptors and enhances their expression at the cell surface. J Mol Biol. 2007;371:622-38 pubmed
    ..Thus, we propose that the association with SERCA2b is required for efficient folding and/or membrane integration of G protein-coupled receptors. ..
  83. Takagi A, Nishiyama C, Maeda K, Tokura T, Kawada H, Kanada S, et al. Role of Sp1 in transcription of human ATP2A2 gene in keratinocytes. J Invest Dermatol. 2008;128:96-103 pubmed
    ..This is early evidence demonstrating that Sp1 plays an important and positive role in ATP2A2 gene expression in NHK in vivo and in vitro. ..
  84. Rouf R, Greytak S, Wooten E, Wu J, Boltax J, Picard M, et al. Increased FOG-2 in failing myocardium disrupts thyroid hormone-dependent SERCA2 gene transcription. Circ Res. 2008;103:493-501 pubmed publisher
    ..b>SERCA2 transcript and protein levels were reduced in FOG-2 transgenic hearts, and FOG-2 overexpression impaired T3-..
  85. Tuusa J, Leskelä T, Petäjä Repo U. Human delta opioid receptor biogenesis is regulated via interactions with SERCA2b and calnexin. FEBS J. 2010;277:2815-29 pubmed publisher
    ..We further hypothesize that the primary role of SERCA2b in this process is to act as a Ca(2+) sensor in the vicinity of active translocons, integrating protein folding with local fluctuations of ER Ca(2+) levels. ..
  86. Earls L, Fricke R, Yu J, Berry R, Baldwin L, Zakharenko S. Age-dependent microRNA control of synaptic plasticity in 22q11 deletion syndrome and schizophrenia. J Neurosci. 2012;32:14132-44 pubmed publisher
    ..The sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA2), which is responsible for loading Ca(2+) into the endoplasmic reticulum (ER), is elevated in this mouse model...
  87. Sukumaran S, Zhang C, Leipold D, Saad O, Xu K, Gadkar K, et al. Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics. AAPS J. 2017;19:130-140 pubmed publisher
    ..are often produced and administered as a mixture of conjugated antibodies with different drug to antibody ratios (DAR) resulting in complex and heterogeneous disposition kinetics...
  88. Graf J, Cook M, Schecter S, Deveney K, Hofmann P, Grey D, et al. Coalition for Global Clinical Surgical Education: The Alliance for Global Clinical Training. J Surg Educ. 2018;75:688-696 pubmed publisher
    ..educators at the Muhimbili University of Health and Allied Sciences/Muhimbili National Hospital (MUHAS/MNH), Dar Es Salaam, Tanzania, on the clinical global surgery training of the HIC surgical residents participating in the ..
  89. Makungu C, Stephen S, Kumburu S, Govella N, Dongus S, Hildon Z, et al. Informing new or improved vector control tools for reducing the malaria burden in Tanzania: a qualitative exploration of perceptions of mosquitoes and methods for their control among the residents of Dar es Salaam. Malar J. 2017;16:410 pubmed publisher
    ..and photovoice methods to explore mosquito control perceptions and practices among residents in four study sites in Dar es Salaam, Tanzania...
  90. Chami M, Gozuacik D, Lagorce D, Brini M, Falson P, Peaucellier G, et al. SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis. J Cell Biol. 2001;153:1301-14 pubmed
    ..These data reveal a further mechanism modulating Ca(2+) accumulation into the ER of nonmuscle cells and highlight the relevance of S1T proteins to the control of apoptosis. ..
  91. de Meis L. Role of the sarcoplasmic reticulum Ca2+-ATPase on heat production and thermogenesis. Biosci Rep. 2001;21:113-37 pubmed
    ..Drugs such as heparin and dimethyl sulfoxide are able to modify the fraction of the chemical energy released during ATP hydrolysis which is used for Ca2+ transport and the fraction which is dissipated in the surrounding medium as heat. ..
  92. Kiewitz R, Acklin C, Schafer B, Maco B, Uhrík B, Wuytack F, et al. Ca2+ -dependent interaction of S100A1 with the sarcoplasmic reticulum Ca2+ -ATPase2a and phospholamban in the human heart. Biochem Biophys Res Commun. 2003;306:550-7 pubmed
    ..Our results support a regulatory role of S100A1 in the contraction-relaxation cycle in the human heart. ..