Gene Symbol: SEPT8
Description: septin 8
Alias: SEP2, septin-8
Species: human
Products:     SEPT8

Top Publications

  1. Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga Griesz A, Busse A, et al. Human septin-septin interaction: CDCrel-1 partners with KIAA0202. FEBS Lett. 2002;519:169-72 pubmed
    ..Expression studies of the two human septins revealed a concomitant expression of both proteins in certain cells. ..
  2. Xin X, Pache M, Zieger B, Bartsch I, Prünte C, Flammer J, et al. Septin expression in proliferative retinal membranes. J Histochem Cytochem. 2007;55:1089-94 pubmed
    We undertook this study to evaluate the expression of septin family members SEPT5, SEPT8, and SEPT11 in proliferative retinal membranes...
  3. Jetha K, Theißen G, Melzer R. Arabidopsis SEPALLATA proteins differ in cooperative DNA-binding during the formation of floral quartet-like complexes. Nucleic Acids Res. 2014;42:10927-42 pubmed publisher
    ..However, SEP1 also bound strongly to CArG-box pairs separated by smaller or larger distances, whereas SEP2 preferred large and SEP4 preferred small inter-site distances for binding...
  4. Zhen Z, Xing X, Xie M, Yang L, Yang X, Zheng Y, et al. MAP kinase Slt2 orthologs play similar roles in conidiation, trap formation, and pathogenicity in two nematode-trapping fungi. Fungal Genet Biol. 2018;116:42-50 pubmed publisher
    ..Real-time polymerase chain reaction-based analyses showed that the transcription of sporulation-related (AbaA, Sep2, and MedA) and cell wall synthesis-related (Chs, Glu, and Gfpa) genes was down-regulated in the mutants compared ..
  5. Park H, Kim S, Kim J, Lee S, Paick J, Ahn T, et al. A Randomized, Placebo-Controlled, Double-Blind, Multi-Center Therapeutic Confirmatory Study to Evaluate the Safety and Efficacy of Avanafil in Korean Patients with Erectile Dysfunction. J Korean Med Sci. 2017;32:1016-1023 pubmed publisher
    ..Q4) from baseline, changes in all domain scores in the IIEF from baseline, Sexual Encounter Profile questions 2-5 (SEP2-5), the Global Efficacy Assessment Question (GEAQ), and the number of subjects whose EF domain score at the 8th ..
  6. Elgendy R, Giantin M, Castellani F, Grotta L, Palazzo F, Dacasto M, et al. Transcriptomic signature of high dietary organic selenium supplementation in sheep: A nutrigenomic insight using a custom microarray platform and gene set enrichment analysis. J Anim Sci. 2016;94:3169-3184 pubmed T40: selenium binding protein 1 (SELENBP1), selenoprotein W1 (SEPW1), glutathione peroxidase 3 (GPX3), and septin 8 (SEPT8). And the expression trends for SEPW1 and SEPT8 were validated using qPCR...
  7. Patzig J, Erwig M, Tenzer S, Kusch K, Dibaj P, Mobius W, et al. Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction. elife. 2016;5: pubmed publisher
    ..Regulated by phosphatidylinositol-(4,5)-bisphosphate (PI(4,5)P2)-levels, myelin septins (SEPT2/SEPT4/SEPT7/SEPT8) and the PI(4,5)P2-adaptor anillin form previously unrecognized filaments that extend longitudinally along ..
  8. Li D, Fu X, Guo L, Huang Z, Li Y, Liu Y, et al. FAR-RED ELONGATED HYPOCOTYL3 activates SEPALLATA2 but inhibits CLAVATA3 to regulate meristem determinacy and maintenance in Arabidopsis. Proc Natl Acad Sci U S A. 2016;113:9375-80 pubmed publisher
    ..We further demonstrate that CLV3, SEPALLATA1 (SEP1), and SEP2 are FHY3 target genes...
  9. O Neill R, Clark D. Partial Functional Diversification of Drosophila melanogaster Septin Genes Sep2 and Sep5. G3 (Bethesda). 2016;6:1947-57 pubmed publisher
    ..Drosophila melanogaster has five septin genes, including the two SEPT6 subgroup members Sep2 and Sep5 We previously found that Sep2 has a unique function in oogenesis, which is not performed by Sep5 Here, we ..

More Information


  1. Wang X, Gao D, Sun J, Liu M, Lun Y, Zheng J, et al. An exon skipping in a SEPALLATA-Like gene is associated with perturbed floral and fruits development in cucumber. J Integr Plant Biol. 2016;58:766-71 pubmed publisher
    ..Csa4G126690 shows high homology to Arabidopsis SEPALLATA2 (SEP2) thus being designated CsSEP2...
  2. Brock G, Montorsi F, Costa P, Shah N, Martínez Jabaloyas J, Hammerer P, et al. Effect of Tadalafil Once Daily on Penile Length Loss and Morning Erections in Patients After Bilateral Nerve-sparing Radical Prostatectomy: Results From a Randomized Controlled Trial. Urology. 2015;85:1090-1096 pubmed publisher
    ..Penile tumescence (SEP1) and ability for vaginal insertion (SEP2) significantly improved vs placebo at the end of double-blind and open-label treatment for patients randomized to ..
  3. Cui Y, Liu X, Shi L, Gao Z. Efficacy and safety of phosphodiesterase type 5 (PDE5) inhibitors in treating erectile dysfunction after bilateral nerve-sparing radical prostatectomy. Andrologia. 2016;48:20-8 pubmed publisher
    ..04, 95% confidence interval (CI) = 2.87-5.22, P < 0.00001]; successful vaginal penetration (SEP2) [the odds ratio (OR) = 14.87, 95%CI = 4.57-48.37, P < 0...
  4. Bai W, Li H, Dai Y, He X, Huang Y, Liu J, et al. An open-label, multicenter, randomized, crossover study comparing sildenafil citrate and tadalafil for treating erectile dysfunction in Chinese men naïve to phosphodiesterase 5 inhibitor therapy. Asian J Androl. 2015;17:61-7 pubmed publisher
    ..3%) strongly the preferred sildenafil. The SEP2 (penetration), SEP3 (successful intercourse), and IIEF-EF domain scores were improved in both tadalafil and ..
  5. Akhmetova K, Balasov M, Huijbregts R, Chesnokov I. Functional insight into the role of Orc6 in septin complex filament formation in Drosophila. Mol Biol Cell. 2015;26:15-28 pubmed publisher
    ..Drosophila septin complex functions depend on the intact GTP-binding and/or hydrolysis domains of Pnut, Sep1, and Sep2. The presence of the functional C-terminal domain of septins is required for the integrity of the complex...
  6. Adam J, Pringle J, Peifer M. Evidence for functional differentiation among Drosophila septins in cytokinesis and cellularization. Mol Biol Cell. 2000;11:3123-35 pubmed
    ..septins showed that Sep1 was not detectable at the cellularization front in the Pnut-deficient embryos, whereas Sep2 was still present in normal levels...
  7. Chahwan R, Gravel S, Matsusaka T, Jackson S. Dma/RNF8 proteins are evolutionarily conserved E3 ubiquitin ligases that target septins. Cell Cycle. 2013;12:1000-8 pubmed publisher
    ..Together, these findings reveal evolutionary and functional conservation of Dma proteins, and suggest that RNF8 maintains genome stability through independent, yet analogous, nuclear and cytoplasmic ubiquitylation activities. ..
  8. Frazer K, Ueda Y, Zhu Y, Gifford V, Garofalo M, Mohandas N, et al. Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region. Genome Res. 1997;7:495-512 pubmed
  9. Steels J, Estey M, Froese C, Reynaud D, Pace Asciak C, Trimble W. Sept12 is a component of the mammalian sperm tail annulus. Cell Motil Cytoskeleton. 2007;64:794-807 pubmed
    ..This study suggests Sept12 may be involved in mammalian fertility. ..
  10. Souza T, Barbosa J. Cloning, overexpression, purification and preliminary characterization of human septin 8. Protein J. 2010;29:328-35 pubmed publisher
    ..Expression of three different constructs encoding human septin 8 were analyzed and the results show that SEPT8GC, a clone expressing the conserved domain plus C-terminal domain ..
  11. Kurkinen K, Marttinen M, Turner L, Natunen T, Mäkinen P, Haapalinna F, et al. SEPT8 modulates ?-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1. J Cell Sci. 2016;129:2224-38 pubmed publisher
    ..b>SEPT8 was found to reduce soluble APP? and A? levels in neuronal cells through a post-translational mechanism leading to ..
  12. Saddler M, Bocconcelli A, Hickmott L, Chiang G, Landea Briones R, Bahamonde P, et al. Characterizing Chilean blue whale vocalizations with DTAGs: a test of using tag accelerometers for caller identification. J Exp Biol. 2017;220:4119-4129 pubmed publisher
    ..We report the occurrence of Southeast Pacific type 2 (SEP2) calls, which exhibit peak frequencies, durations and timing consistent with previous recordings made using towed ..
  13. Liu H, Huang R, Ma J, Sui S, Guo Y, Liu D, et al. Two C3H Type Zinc Finger Protein Genes, CpCZF1 and CpCZF2, from Chimonanthus praecox Affect Stamen Development in Arabidopsis. Genes (Basel). 2017;8: pubmed publisher
  14. Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, et al. Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202). Gene. 2003;312:313-20 pubmed
    b>SEPT8 (KIAA0202) is a member of the highly conserved septin family. Septins are membrane-associated GTPases which are involved in cytokinesis and cellular morphogenesis...
  15. Martinez C, Sanjuan M, Dent J, Karlsson L, Ware J. Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol. Biochem J. 2004;382:783-91 pubmed
    ..SEPT4 [previously designated H5, CDCrel-2 (cell-division-control-related-2), PNUTL2], SEPT5 (CDCrel-1, PNUTL1) and SEPT8 (KIAA0202)...
  16. Blaser S, Röseler S, Rempp H, Bartsch I, Bauer H, Lieber M, et al. Human endothelial cell septins: SEPT11 is an interaction partner of SEPT5. J Pathol. 2006;210:103-10 pubmed
    ..SEPT11 has strong homology to SEPT8. Previously, we identified the interaction of SEPT5 and SEPT8...
  17. Ridruechai C, Mahasirimongkol S, Phromjai J, Yanai H, Nishida N, Matsushita I, et al. Association analysis of susceptibility candidate region on chromosome 5q31 for tuberculosis. Genes Immun. 2010;11:416-22 pubmed publisher
    ..Of these, 75 SNPs located within candidate genes covering SLC22A4, SLC22A5, IRF1, IL5, RAD50, IL13, IL4, KIF3A and SEPT8 were genotyped using the DigiTag2 assay...
  18. Sevinc A, Fung L. Non-erythroid beta spectrin interacting proteins and their effects on spectrin tetramerization. Cell Mol Biol Lett. 2011;16:595-609 pubmed publisher
    ..quot;glioma tumor suppressor candidate region gene 2" (residues 1-478), a fragment (residues 74-442) of septin 8 isoform c, a fragment (residues 704-953) of "coatomer protein complex, subunit beta 1, a fragment (residues ..
  19. Bläser S, Horn J, Würmell P, Bauer H, Strümpell S, Nurden P, et al. The novel human platelet septin SEPT8 is an interaction partner of SEPT4. Thromb Haemost. 2004;91:959-66 pubmed
    ..Using the yeast two-hybrid system we had demonstrated that SEPT5 partners with SEPT8. The aim of this study was to identify other interaction partners of the human platelet septin SEPT8...
  20. Macara I, Baldarelli R, Field C, Glotzer M, Hayashi Y, Hsu S, et al. Mammalian septins nomenclature. Mol Biol Cell. 2002;13:4111-3 pubmed
    ..The human and mouse septin genes will be named SEPT1-SEPT10 and Sept1-Sept10, respectively. Splice variants will be designated by an underscore followed by a lowercase "v" and a number, e.g., SEPT4_v1. ..
  21. Yang T, Gao Y, Chen J. KIAA0202, a human septin family member, interacting with hPFTAIRE1. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2002;34:520-5 pubmed
    ..Its C-terminus is a coiled-coil structure and its N-terminus is a variable region. Our results suggest that the KIAA0202 may play important roles in functional regulation of hPFTAIRE1. ..
  22. Akhmetova K, Balasov M, Svitin A, Chesnokova E, RENFROW M, Chesnokov I. Phosphorylation of Pnut in the Early Stages of Drosophila Embryo Development Affects Association of the Septin Complex with the Membrane and Is Important for Viability. G3 (Bethesda). 2018;8:27-38 pubmed publisher
    ..In Drosophila, septin proteins Pnut, Sep1, and Sep2 form a hexameric septin complex...