SEPT2

Summary

Gene Symbol: SEPT2
Description: septin 2
Alias: DIFF6, NEDD-5, NEDD5, Pnutl3, hNedd5, septin-2, neural precursor cell expressed, developmentally down-regulated 5
Species: human
Products:     SEPT2

Top Publications

  1. Kinoshita M, Kumar S, Mizoguchi A, Ide C, Kinoshita A, Haraguchi T, et al. Nedd5, a mammalian septin, is a novel cytoskeletal component interacting with actin-based structures. Genes Dev. 1997;11:1535-47 pubmed
    The mouse Nedd5 gene encodes a 41.5-kD GTPase similar to the Saccharomyces and Drosophila septins essential for cytokinesis...
  2. Kremer B, Adang L, Macara I. Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. Cell. 2007;130:837-50 pubmed
    Mammalian septins are GTP-binding proteins the functions of which are not well understood. Knockdown of SEPT2, 6, and 7 causes stress fibers to disintegrate and cells to lose polarity...
  3. Kinoshita A, Kinoshita M, Akiyama H, Tomimoto H, Akiguchi I, Kumar S, et al. Identification of septins in neurofibrillary tangles in Alzheimer's disease. Am J Pathol. 1998;153:1551-60 pubmed
    ..We detected expression of the human septin genes Nedd5, H5, Diff6, and hCDC100 in postmortem brain tissues using the reverse transcription-coupled polymerase chain ..
  4. Beites C, Xie H, Bowser R, Trimble W. The septin CDCrel-1 binds syntaxin and inhibits exocytosis. Nat Neurosci. 1999;2:434-9 pubmed
    ..In detergent extracts, CDCrel-1 and another septin, Nedd5, immunoprecipitated with the SNARE protein syntaxin by directly binding to syntaxin via the SNARE interaction ..
  5. Spiliotis E, Hunt S, Hu Q, Kinoshita M, Nelson W. Epithelial polarity requires septin coupling of vesicle transport to polyglutamylated microtubules. J Cell Biol. 2008;180:295-303 pubmed publisher
    ..Here, we show that in epithelial cells septin 2 (SEPT2) fibers colocalize with a subset of microtubule tracks composed of polyglutamylated (polyGlu) tubulin, and ..
  6. Surka M, Tsang C, Trimble W. The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis. Mol Biol Cell. 2002;13:3532-45 pubmed
    ..We show that during interphase, MSF colocalizes with actin, microtubules, and another mammalian septin, Nedd5, and coprecipitates with six septin proteins...
  7. Sheffield P, Oliver C, Kremer B, Sheng S, Shao Z, Macara I. Borg/septin interactions and the assembly of mammalian septin heterodimers, trimers, and filaments. J Biol Chem. 2003;278:3483-8 pubmed
    ..effector of the Cdc42 GTPase, binds specifically to a septin heterodimer composed of Sept6 and Sept7 and to the Sept2/6/7 trimer, but not to septin monomers or to other heterodimers...
  8. Vega I, Hsu S. The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells. Neuroreport. 2003;14:31-7 pubmed
    b>Nedd5 is a septin protein enriched in brain and associates with the exocyst complex, a protein complex required for neurite outgrowth in neuroendocrine PC12 cells...
  9. Ihara M, Tomimoto H, Kitayama H, Morioka Y, Akiguchi I, Shibasaki H, et al. Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies. J Biol Chem. 2003;278:24095-102 pubmed
    ..a member of the septin protein family, is consistently found in these inclusions, whereas five other septins (Sept2, Sept5, Sept6, Sept7, and Sept8) are not found in these inclusions...

More Information

Publications68

  1. Ghossoub R, Hu Q, Failler M, Rouyez M, Spitzbarth B, Mostowy S, et al. Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length. J Cell Sci. 2013;126:2583-94 pubmed publisher
    ..investigated the role of septins in the primary cilium of retinal pigmented epithelial (RPE) cells, and found that SEPT2 forms a 1:1:1 complex with SEPT7 and SEPT9 and that the three members of this complex colocalize along the length ..
  2. Nagata K, Asano T, Nozawa Y, Inagaki M. Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11. J Biol Chem. 2004;279:55895-904 pubmed
    ..Using specific antibodies, we found at least five septins, Sept2, Sept7, Sept8, Sept9b, and Sept11, in septin complexes affinity-purified with anti-Sept7 antibody-conjugated ..
  3. Spiliotis E, Kinoshita M, Nelson W. A mitotic septin scaffold required for Mammalian chromosome congression and segregation. Science. 2005;307:1781-5 pubmed
    ..Mammalian septins may thus form a mitotic scaffold for CENP-E and other effectors to coordinate cytokinesis with chromosome congression and segregation. ..
  4. Bowen J, Hwang D, Bai X, Roy D, Spiliotis E. Septin GTPases spatially guide microtubule organization and plus end dynamics in polarizing epithelia. J Cell Biol. 2011;194:187-97 pubmed publisher
    ..Our results suggest that septins provide the directional guidance cues necessary for polarizing the epithelial MT network. ..
  5. Sandrock K, Bartsch I, Bläser S, Busse A, Busse E, Zieger B. Characterization of human septin interactions. Biol Chem. 2011;392:751-61 pubmed publisher
    ..SEPT9 can substitute for septins of the SEPT2 group and partially for SEPT7...
  6. Sirajuddin M, Farkasovsky M, Hauer F, Kühlmann D, Macara I, Weyand M, et al. Structural insight into filament formation by mammalian septins. Nature. 2007;449:311-5 pubmed
    ..Here we present the structures of the human SEPT2 G domain and the heterotrimeric human SEPT2-SEPT6-SEPT7 complex...
  7. Nakahira M, Macedo J, Seraphim T, Cavalcante N, Souza T, Damalio J, et al. A draft of the human septin interactome. PLoS ONE. 2010;5:e13799 pubmed publisher
    ..Septins of the SEPT6 group preferentially interacted with septins of the SEPT2 group (p<0.001), SEPT3 group (p<0.001) and SEPT7 group (p<0.001)...
  8. Koshelev I. [Affinity chromatography and proteomic screening as the effective method for S100A4 new protein targets discovery]. Mol Biol (Mosk). 2014;48:868-72 pubmed
    ..With the same' method we had identify some new S100A4 target proteins such as cytoskeleton proteins Sept2, Sept7, Sept11 and this interaction would can to highlight as S100A4 would regulate cell motility...
  9. Pellagatti A, Armstrong R, Steeples V, Sharma E, Repapi E, Singh S, et al. Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations. Blood. 2018;: pubmed publisher
    ..Functional studies demonstrated that knockdown of the mitosis regulators SEPT2 and AKAP8, aberrantly spliced target genes of SF3B1 and SRSF2 mutations respectively, led to impaired erythroid ..
  10. Huang C, Wang Y, Chen Y, Chen M, Chiang H, Kuo P, et al. CDC42 Negatively Regulates Testis-Specific SEPT12 Polymerization. Int J Mol Sci. 2018;19: pubmed publisher
    ..Some studies have indicated that CDC42 negatively regulates the polymerization of SEPT2/6/7 complexes in mammalian cell lines...
  11. Xu C, Zhang W, Zhang X, Zhou D, Qu L, Liu J, et al. Coupling function of cyclin-dependent kinase 2 and Septin2 in the promotion of hepatocellular carcinoma. Cancer Sci. 2019;110:540-549 pubmed publisher
    ..Cyclin-dependent kinase 2 (CDK2) and Septin2 (SEPT2) are 2 known oncogenic molecules but the mechanism of functional interactions remains unclear...
  12. Deb B, Hasan G. SEPT7-mediated regulation of Ca2+ entry through Orai channels requires other septin subunits. Cytoskeleton (Hoboken). 2018;: pubmed publisher
    ..Septins of the SEPT2 subgroup act as positive regulators of SOCE in human nonexcitable cells...
  13. Xu D, Liu A, Wang X, Chen Y, Shen Y, Tan Z, et al. Repression of Septin9 and Septin2 suppresses tumor growth of human glioblastoma cells. Cell Death Dis. 2018;9:514 pubmed publisher
    ..In this study, we identified Septin9 (SEPT9) and Septin2 (SEPT2) as GBM-related genes through integrated multi-omics analysis across independent transcriptomic and proteomic ..
  14. Lobato Márquez D, Krokowski S, Sirianni A, Larrouy Maumus G, Mostowy S. A requirement for septins and the autophagy receptor p62 in the proliferation of intracellular Shigella. Cytoskeleton (Hoboken). 2018;: pubmed publisher
    ..Here, we found that intracellular Shigella fail to efficiently proliferate in SEPT2-, SEPT7-, or p62/SQSTM1-depleted cells...
  15. Sala F, Valadares N, Macedo J, Borges J, Garratt R. Heterotypic Coiled-Coil Formation is Essential for the Correct Assembly of the Septin Heterofilament. Biophys J. 2016;111:2608-2619 pubmed publisher
    ..Currently, even for the best characterized human septin heterocomplex (SEPT2/SEPT6/SEPT7), the role of C-terminal domain is not fully established, and this is partly due to the absence of ..
  16. Chen L, Wang B, Wang S, Yang J, Hu J, Xie Z, et al. OPMSP: A Computational Method Integrating Protein Interaction and Sequence Information for the Identification of Novel Putative Oncogenes. Protein Pept Lett. 2016;23:1081-1094 pubmed
    ..Six of these genes-ESR1, CDK9, SEPT2, HOXA10, LMX1B, and NR2C2-are extensively discussed...
  17. Zeraik A, Staykova M, Fontes M, Nemuraitė I, Quinlan R, Araújo A, et al. Biophysical dissection of schistosome septins: Insights into oligomerization and membrane binding. Biochimie. 2016;131:96-105 pubmed publisher
    ..proprieties of its SmSEPT5 and SmSEPT10 septins are consistent with their human counterparts of subgroups SEPT2 and SEPT6, respectively...
  18. Calvo F, Ranftl R, Hooper S, Farrugia A, Moeendarbary E, Bruckbauer A, et al. Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts. Cell Rep. 2015;13:2699-714 pubmed publisher
    ..Cdc42EP3 functions by coordinating the actin and septin networks. Furthermore, depletion of SEPT2 has similar effects to those of loss of Cdc42EP3, indicating a role for the septin network in the tumor stroma...
  19. Patzig J, Erwig M, Tenzer S, Kusch K, Dibaj P, Mobius W, et al. Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction. elife. 2016;5: pubmed publisher
    ..Regulated by phosphatidylinositol-(4,5)-bisphosphate (PI(4,5)P2)-levels, myelin septins (SEPT2/SEPT4/SEPT7/SEPT8) and the PI(4,5)P2-adaptor anillin form previously unrecognized filaments that extend ..
  20. Steels J, Estey M, Froese C, Reynaud D, Pace Asciak C, Trimble W. Sept12 is a component of the mammalian sperm tail annulus. Cell Motil Cytoskeleton. 2007;64:794-807 pubmed
    ..This study suggests Sept12 may be involved in mammalian fertility. ..
  21. Sakai K, Kurimoto M, Tsugu A, Hubbard S, Trimble W, Rutka J. Expression of Nedd5, a mammalian septin, in human brain tumors. J Neurooncol. 2002;57:169-77 pubmed
    ..b>Nedd5 is a mammalian septin known to associate with actin-based structures such as the contractile ring and stress ..
  22. Kliza K, Taumer C, Pinzuti I, Franz Wachtel M, Kunzelmann S, Stieglitz B, et al. Internally tagged ubiquitin: a tool to identify linear polyubiquitin-modified proteins by mass spectrometry. Nat Methods. 2017;14:504-512 pubmed publisher
    ..We demonstrated that linear polyubiquitination of the novel LUBAC substrate TRAF6 is essential for NF?B signaling. ..
  23. Wang Y, Zhang K, Shi X, Wang C, Wang F, Fan J, et al. Critical role of bacterial isochorismatase in the autophagic process induced by Acinetobacter baumannii in mammalian cells. FASEB J. 2016;30:3563-3577 pubmed
    ..baumannii induced a complete, ubiquitin-mediated autophagic response that is dependent upon septins SEPT2 and SEPT9 in mammalian cells. We also demonstrated that autophagy induced by A...
  24. Kim C, Seol S, Song O, Park J, Jang S. An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication. J Virol. 2007;81:3852-65 pubmed
    ..These results indicate that the host proteins hnRNP A1 and septin 6 play important roles in the replication of HCV through RNA-protein and protein-protein interactions. ..
  25. Low C, Macara I. Structural analysis of septin 2, 6, and 7 complexes. J Biol Chem. 2006;281:30697-706 pubmed
    ..light scattering techniques, we have characterized the conformation of a complex of filamentous human septins, Sept2, Sept6, and Sept7...
  26. Cerveira N, Correia C, Bizarro S, Pinto C, Lisboa S, Mariz J, et al. SEPT2 is a new fusion partner of MLL in acute myeloid leukemia with t(2;11)(q37;q23). Oncogene. 2006;25:6147-52 pubmed
    ..demonstrated a rearrangement of the MLL gene and molecular genetic analyses identified a septin family gene, SEPT2, located on chromosome 2q37, as the fusion partner of MLL...
  27. Mostowy S, Janel S, Forestier C, Roduit C, Kasas S, Pizarro Cerda J, et al. A role for septins in the interaction between the Listeria monocytogenes INVASION PROTEIN InlB and the Met receptor. Biophys J. 2011;100:1949-59 pubmed publisher
    ..We recently discovered that different septins, SEPT2 and SEPT11, regulate the InlB-mediated entry of Listeria monocytogenes into host cells...
  28. Mori T, Miura K, Fujiwara T, Shin S, Inazawa J, Nakamura Y. Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6. Cytogenet Cell Genet. 1996;73:224-7 pubmed
    We have isolated a novel human cDNA that encodes a protein homologous to murine H5 and Diff6, and to yeast CDC10, and mapped it to chromosome region 2q37 by fluorescent in situ hybridization...
  29. Hsu S, Hazuka C, Roth R, Foletti D, Heuser J, Scheller R. Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. Neuron. 1998;20:1111-22 pubmed
    ..The sec6/8 and septin complexes likely play an important role in trafficking vesicles and organizing proteins at the plasma membrane of neurons. ..
  30. Okumura A, Pitha P, Harty R. ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity. Proc Natl Acad Sci U S A. 2008;105:3974-9 pubmed publisher
    ..These data provide evidence of antiviral activity of ISG15 against Ebola virus and suggest a mechanism of action involving disruption of Nedd4 function and subsequent ubiquitination of VP40. ..
  31. Ribet D, Boscaini S, Cauvin C, Siguier M, Mostowy S, Echard A, et al. SUMOylation of human septins is critical for septin filament bundling and cytokinesis. J Cell Biol. 2017;216:4041-4052 pubmed publisher
    ..Human septins are encoded by 13 different genes and are classified into four groups based on sequence homology (SEPT2, SEPT3, SEPT6, and SEPT7 groups)...
  32. Kaplan C, Steinmann M, Zapiórkowska N, Ewers H. Functional Redundancy of Septin Homologs in Dendritic Branching. Front Cell Dev Biol. 2017;5:11 pubmed publisher
    ..This is best understood for the isoforms of the SEPT2 group, which form a homodimer at the center of septin complexes...
  33. Yu W, Ding X, Chen F, Liu M, Shen S, Gu X, et al. The phosphorylation of SEPT2 on Ser218 by casein kinase 2 is important to hepatoma carcinoma cell proliferation. Mol Cell Biochem. 2009;325:61-7 pubmed publisher
    b>SEPT2 plays an important role in cell division through its effect on cytoskeletons. It is a GTP-binding protein and can also form filament with SEPT6 and SEPT7...
  34. Mostowy S, Danckaert A, Tham T, Machu C, Guadagnini S, Pizarro Cerd J, et al. Septin 11 restricts InlB-mediated invasion by Listeria. J Biol Chem. 2009;284:11613-21 pubmed publisher
    ..We previously showed that SEPT2, SEPT9, and SEPT11 colocalize with several bacteria entering into mammalian non-phagocytic cells, and SEPT2 was ..
  35. Margutti P, Sorice M, Conti F, Delunardo F, Racaniello M, Alessandri C, et al. Screening of an endothelial cDNA library identifies the C-terminal region of Nedd5 as a novel autoantigen in systemic lupus erythematosus with psychiatric manifestations. Arthritis Res Ther. 2005;7:R896-903 pubmed
    ..with psychosis, we identified one positive strongly reactive clone encoding the C-terminal region (C-ter) of Nedd5, an intracytoplasmatic protein of the septin family...
  36. Tokhtaeva E, Capri J, Marcus E, Whitelegge J, Khuzakhmetova V, Bukharaeva E, et al. Septin dynamics are essential for exocytosis. J Biol Chem. 2015;290:5280-97 pubmed publisher
    ..The results demonstrate a stimulatory role of septin-2 and the dynamic reorganization of septin oligomers in exocytosis. ..
  37. Jian W, Zhong L, Wen J, Tang Y, Qiu B, Wu Z, et al. SEPTIN2 and STATHMIN Regulate CD99-Mediated Cellular Differentiation in Hodgkin's Lymphoma. PLoS ONE. 2015;10:e0127568 pubmed publisher
    ..These results suggest that SEPTIN2-mediated cytoskeletal rearrangement and STATHMIN-mediated differentiation may contribute to changes in cell morphology and differentiation of H/RS cells with CD99 upregulation in HL. ..
  38. Zhang N, Liu L, Fan N, Zhang Q, Wang W, Zheng M, et al. The requirement of SEPT2 and SEPT7 for migration and invasion in human breast cancer via MEK/ERK activation. Oncotarget. 2016;7:61587-61600 pubmed publisher
    ..We then examined the expression and subcellular distribution of the selected septins SEPT2 and SEPT7 in breast cancer cells, revealing a rather variable localization of the two proteins with cell cycle ..
  39. Volceanov L, Herbst K, Biniossek M, Schilling O, Haller D, Nölke T, et al. Septins arrange F-actin-containing fibers on the Chlamydia trachomatis inclusion and are required for normal release of the inclusion by extrusion. MBio. 2014;5:e01802-14 pubmed publisher
    ..We report here that the septins SEPT2, -9, -11, and probably -7 form fibrillar structures around the chlamydial inclusion...
  40. Cerveira N, Santos J, Pinheiro M, Snijder S, van der Lelie H, Mellink C, et al. A novel MLL-SEPT2 fusion variant in therapy-related myelodysplastic syndrome. Cancer Genet Cytogenet. 2008;185:62-4 pubmed publisher
  41. Neubauer K, Zieger B. The Mammalian Septin Interactome. Front Cell Dev Biol. 2017;5:3 pubmed publisher
    ..which can be classified into four distinct subgroups based on the sequence homology of their domain structure (SEPT2, SEPT3, SEPT6, and SEPT7 subgroup)...
  42. Angelis D, Spiliotis E. Septin Mutations in Human Cancers. Front Cell Dev Biol. 2016;4:122 pubmed
    ..Over 25% of the annotated mutations in SEPT2, SEPT4, and SEPT9 belong to large intestine tumors...
  43. Cao L, Shao Z, Liang H, Zhang D, Yang X, Jiang X, et al. Activation of peroxisome proliferator-activated receptor-γ (PPARγ) inhibits hepatoma cell growth via downregulation of SEPT2 expression. Cancer Lett. 2015;359:127-35 pubmed publisher
    ..Among the altered proteins, septin 2 (SEPT2) was found to exhibit oncogenic function...
  44. Angelis D, Karasmanis E, Bai X, Spiliotis E. In silico docking of forchlorfenuron (FCF) to septins suggests that FCF interferes with GTP binding. PLoS ONE. 2014;9:e96390 pubmed publisher
    ..Docking of FCF with SEPT2 and SEPT3 indicated that FCF interacts preferentially with the nucleotide-binding pockets of septins...
  45. Koshelev Y, Kiselev S, Georgiev G. Interaction of the S100A4 (Mts1) protein with septins Sept2, Sept6, and Sept7 in vitro. Dokl Biochem Biophys. 2003;391:195-7 pubmed
  46. Hall P, Jung K, Hillan K, Russell S. Expression profiling the human septin gene family. J Pathol. 2005;206:269-78 pubmed
    ..expressed in all tissue types but some show high expression in lymphoid (SEPT1, 6, 9, and 12) or brain tissues (SEPT2, 3, 4, 5, 7, 8, and 11). For a given septin, some isoforms are highly expressed in the brain and others are not...
  47. Nölke T, Schwan C, Lehmann F, Østevold K, Pertz O, Aktories K. Septins guide microtubule protrusions induced by actin-depolymerizing toxins like Clostridium difficile transferase (CDT). Proc Natl Acad Sci U S A. 2016;113:7870-5 pubmed publisher
    ..Here, we show that septins (SEPT) are essential for CDT-induced protrusion formation. SEPT2, -6, -7, and -9 accumulate at predetermined protrusion sites and form collar-like structures at the base of ..
  48. Pissuti Damalio J, Garcia W, Alves Macêdo J, de Almeida Marques I, Andreu J, Giraldo R, et al. Self assembly of human septin 2 into amyloid filaments. Biochimie. 2012;94:628-36 pubmed publisher
    ..b>Septin 2 (SEPT2) is a member of the septin family and has been associated with neurofibrillary tangles and other ..
  49. Kuo Y, Shen Y, Chen H, Lin Y, Wang Y, Chen Y, et al. SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins. J Cell Sci. 2015;128:923-34 pubmed publisher
    ..Here, we found that SEPT12 formed a filamentous structure with SEPT7, SEPT 6, SEPT2 and SEPT4 at the sperm annulus...
  50. García Z, Silio V, Marqués M, Cortes I, Kumar A, Hernandez C, et al. A PI3K activity-independent function of p85 regulatory subunit in control of mammalian cytokinesis. EMBO J. 2006;25:4740-51 pubmed
    ..by which p85alpha regulates cytokinesis; p85alpha deletion reduced Cdc42 activation in the cleavage furrow and septin 2 accumulation at this site...
  51. She Y, Huang Y, Zhang L, Trimble W. Septin 2 phosphorylation: theoretical and mass spectrometric evidence for the existence of a single phosphorylation site in vivo. Rapid Commun Mass Spectrom. 2004;18:1123-30 pubmed
    ..We present herein a combined theoretical and experimental approach for the analysis of Septin 2 (Sept2) monophosphorylation in vivo...
  52. Damalio J, Nobre T, Lopes J, Oliveira O, Araujo A. Lipid interaction triggering Septin2 to assembly into ?-sheet structures investigated by Langmuir monolayers and PM-IRRAS. Biochim Biophys Acta. 2013;1828:1441-8 pubmed publisher
    ..SEPT1, SEPT4, and SEPT2 have been found in deposits known as neurofibrillary tangles and glial fibrils in Alzheimer's disease...
  53. Diesenberg K, Beerbaum M, Fink U, Schmieder P, Krauss M. SEPT9 negatively regulates ubiquitin-dependent downregulation of EGFR. J Cell Sci. 2015;128:397-407 pubmed publisher
    ..Taken together, these data provide a mechanistic explanation of how SEPT9, though acting exclusively at the plasma membrane, impairs the sorting of EGFRs into the degradative pathway. ..
  54. Lu H, Galeano M, Ott E, Kaeslin G, Kausalya P, Kramer C, et al. Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease. Nat Genet. 2017;49:1025-1034 pubmed publisher
    ..Together, these data provide what is, to our knowledge, the first conclusive evidence that ARPKD is not a homogeneous disorder and further establish DZIP1L as a second gene involved in ARPKD pathogenesis. ..
  55. Sidhaye V, Chau E, Breysse P, King L. Septin-2 mediates airway epithelial barrier function in physiologic and pathologic conditions. Am J Respir Cell Mol Biol. 2011;45:120-6 pubmed publisher
    ..These findings indicate that septin-2 plays a fundamental role in regulating barrier function by altering cortical actin expression...
  56. Pagliuso A, Tham T, Stevens J, Lagache T, Persson R, Salles A, et al. A role for septin 2 in Drp1-mediated mitochondrial fission. EMBO Rep. 2016;17:858-73 pubmed publisher
    ..Here, we report that the cytoskeletal component septin 2 is involved in Drp1-dependent mitochondrial fission in mammalian cells...
  57. Marcus E, Tokhtaeva E, Turdikulova S, Capri J, Whitelegge J, Scott D, et al. Septin oligomerization regulates persistent expression of ErbB2/HER2 in gastric cancer cells. Biochem J. 2016;473:1703-18 pubmed publisher
  58. Brausemann A, Gerhardt S, Schott A, Einsle O, Große Berkenbusch A, Johnsson N, et al. Crystal structure of Cdc11, a septin subunit from Saccharomyces cerevisiae. J Struct Biol. 2016;193:157-161 pubmed publisher
    ..Size exclusion chromatography analysis revealed that Cdc11 forms homodimers through its C-terminal coiled coil tail. ..
  59. Yu J, Zhang W, Tang H, Qian H, Yang J, Zhu Z, et al. Septin 2 accelerates the progression of biliary tract cancer and is negatively regulated by mir-140-5p. Gene. 2016;589:20-26 pubmed publisher
    ..In this study, we identified SEPT2 as a tumor-promoting gene that is regulated by miR-140-5p in BTC...