Gene Symbol: SEPT12
Description: septin 12
Alias: SPGF10, septin-12, testicular tissue protein Li 168
Species: human
Products:     SEPT12

Top Publications

  1. Hall P, Jung K, Hillan K, Russell S. Expression profiling the human septin gene family. J Pathol. 2005;206:269-78 pubmed
    ..It is a key step in understanding the role of septins in physiological and pathological states and provides insight into the complexity of septin biology. ..
  2. Ding X, Yu W, Liu M, Shen S, Chen F, Wan B, et al. SEPT12 interacts with SEPT6 and this interaction alters the filament structure of SEPT6 in Hela cells. J Biochem Mol Biol. 2007;40:973-8 pubmed
    ..Here we described the characterization of SEPT12, sharing closest homology to SEPT3 and SEPT9...
  3. Lin Y, Wang Y, Chen H, Kuo Y, Chiou Y, Lin H, et al. SEPTIN12 genetic variants confer susceptibility to teratozoospermia. PLoS ONE. 2012;7:e34011 pubmed publisher
    ..Ex vivo experiment showed truncated SEPT12 inhibits filament formation in a dose-dependent manner...
  4. Lin Y, Lin Y, Wang Y, Yu I, Lin Y, Wang Y, et al. The expression level of septin12 is critical for spermiogenesis. Am J Pathol. 2009;174:1857-68 pubmed publisher
    ..In addition, increased numbers of spermatozoa with abnormal head, neck, and tail morphologies lacked SEPT12 immunostaining signals, as compared with normal spermatozoa...
  5. Kuo Y, Lin Y, Chen H, Wang Y, Chiou Y, Lin H, et al. SEPT12 mutations cause male infertility with defective sperm annulus. Hum Mutat. 2012;33:710-9 pubmed publisher
    ..b>Septin 12 (SEPT12) is a testis-specific gene critical for the terminal differentiation of male germ cells...
  6. Kuo P, Chiang H, Wang Y, Kuo Y, Chen M, Yu I, et al. SEPT12-microtubule complexes are required for sperm head and tail formation. Int J Mol Sci. 2013;14:22102-16 pubmed publisher
    ..We suggest that a loss of SEPT12 affects the biological function of microtublin functions and causes spermiogenesis defects...
  7. Ding X, Yu W, Liu M, Shen S, Chen F, Cao L, et al. GTP binding is required for SEPT12 to form filaments and to interact with SEPT11. Mol Cells. 2008;25:385-9 pubmed
    ..Here we report the biochemical and immunocytochemical characterization of a recently identified mammalian septin, SEPT12. SEPT12 binds GTP in vitro, and a mutation (Gly56 to Asn) in the GTP-binding motif abolished binding...
  8. Kuo P, Tseng J, Chen H, Wu C, Omar H, Wang C, et al. Identification of SEPTIN12 as a novel target of the androgen and estrogen receptors in human testicular cells. Biochimie. 2018;158:1-9 pubmed publisher
    SEPTIN12 (SEPT12) is a testis-enriched gene that is downregulated in the testis of infertile men with severe spermatogenic defects...
  9. Hosseinifar H, Shafipour M, Modarresi T, Azad M, Sadighi Gilani M, Shahhosseini M, et al. Relationship between absence of annulus and asthenozoospermia in Iranian men. J Assist Reprod Genet. 2014;31:1681-5 pubmed publisher
    ..DNA sequencing for all coding exons of SEPT12 was performed for a patient using peripheral blood sample...

More Information


  1. Huang C, Wang Y, Chen Y, Chen M, Chiang H, Kuo P, et al. CDC42 Negatively Regulates Testis-Specific SEPT12 Polymerization. Int J Mol Sci. 2018;19: pubmed publisher
    ..However, the regulators of SEPT12 are completely unknown...
  2. Neubauer K, Zieger B. The Mammalian Septin Interactome. Front Cell Dev Biol. 2017;5:3 pubmed publisher
    ..To date, 13 different septin genes have been identified in mammals (SEPT1 to SEPT12 and SEPT14), which can be classified into four distinct subgroups based on the sequence homology of ..
  3. Shen Y, Wang H, Kuo Y, Shih S, Hsu C, Chen Y, et al. SEPT12 phosphorylation results in loss of the septin ring/sperm annulus, defective sperm motility and poor male fertility. PLoS Genet. 2017;13:e1006631 pubmed publisher
    ..Here, we showed that SEPT12 was phosphorylated on Ser198 using mass spectrometry, and we generated SEPT12 phosphomimetic knock-in (KI) mice to ..
  4. Miyakawa H, Miyamoto T, Koh E, Tsujimura A, Miyagawa Y, Saijo Y, et al. Single-nucleotide polymorphisms in the SEPTIN12 gene may be a genetic risk factor for Japanese patients with Sertoli cell-only syndrome. J Androl. 2012;33:483-7 pubmed publisher
    ..The genotype and allele frequencies in SNP3, SNP4, and SNP6 were notably higher in the SCOS group than in the control group (P < .001). These results suggest that SEPTIN12 might play a critical role in human spermatogenesis. ..
  5. Miyamoto T, Tsujimura A, Miyagawa Y, Koh E, Namiki M, Horikawa M, et al. Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men. J Assist Reprod Genet. 2012;29:47-51 pubmed publisher
    ..05). The c.204G>C (Gln38His) variant in the SEPTIN12 gene was associated with increased susceptibility to azoospermia caused by meiotic arrest. ..
  6. Kinoshita M. The septins. Genome Biol. 2003;4:236 pubmed
    ..The septins are guanine-nucleotide binding proteins that mostly form filaments. They are important in cytokinesis and also have roles in sporulation in yeasts and embryonic development and in the nervous system in animals. ..
  7. Yeh C, Kuo P, Wang Y, Wu Y, Chen M, Lin D, et al. SEPT12/SPAG4/LAMINB1 complexes are required for maintaining the integrity of the nuclear envelope in postmeiotic male germ cells. PLoS ONE. 2015;10:e0120722 pubmed publisher
    ..Our previous studies based on a knockout mice model indicated that SEPT12 proteins are critical for the terminal morphological formation of sperm...
  8. Lai T, Wu Y, Wang Y, Chen M, Wang P, Chen T, et al. SEPT12-NDC1 Complexes Are Required for Mammalian Spermiogenesis. Int J Mol Sci. 2016;17: pubmed
    ..Our knockout and knock-in mice models demonstrated that SEPTIN12 (SEPT12) is vital for the formation of sperm morphological characteristics during spermiogenesis...
  9. Kuo Y, Shen Y, Chen H, Lin Y, Wang Y, Chen Y, et al. SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins. J Cell Sci. 2015;128:923-34 pubmed publisher
    Male infertility has become a worldwide health problem, but the etiologies of most cases are still unknown. SEPT12, a GTP-binding protein, is involved in male fertility...