SENP3

Summary

Gene Symbol: SENP3
Description: SUMO specific peptidase 3
Alias: SMT3IP1, SSP3, Ulp1, sentrin-specific protease 3, SUMO-1-specific protease 3, SUMO1/sentrin/SMT3 specific peptidase 3, sentrin/SUMO-specific protease 3
Species: human
Products:     SENP3

Top Publications

  1. Gong L, Yeh E. Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. J Biol Chem. 2006;281:15869-77 pubmed
    ..Thus, SENP5 also possesses limited SUMO-1 isopeptidase activity. We were also able to show that SENP3 has substrate specificity similar to that of SENP5...
  2. Finkbeiner E, Haindl M, Muller S. The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex. EMBO J. 2011;30:1067-78 pubmed publisher
    ..Previous work revealed a critical role for the SUMO-specific protease SENP3 in the nucleolar steps of ribosome biogenesis...
  3. Yun C, Wang Y, Mukhopadhyay D, Backlund P, Kolli N, Yergey A, et al. Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases. J Cell Biol. 2008;183:589-95 pubmed publisher
    ..Here, we show that Ulp/SENP family members SENP3 and SENP5 localize within the granular component of the nucleolus, a subnucleolar compartment that contains B23/..
  4. Nishida T, Tanaka H, Yasuda H. A novel mammalian Smt3-specific isopeptidase 1 (SMT3IP1) localized in the nucleolus at interphase. Eur J Biochem. 2000;267:6423-7 pubmed
    A novel Smt3-specific isopeptidase, SMT3IP1, was cloned using a yeast two-hybrid screen with Smt3b as bait...
  5. Yeh E, Gong L, Kamitani T. Ubiquitin-like proteins: new wines in new bottles. Gene. 2000;248:1-14 pubmed
    ..This review will focus on the biology and biochemistry of the Sentrin/SUMO and NEDD8 modification pathways, which are clearly distinct from the ubiquitination pathway and have unique biological functions. ..
  6. Di Bacco A, Ouyang J, Lee H, Catic A, Ploegh H, Gill G. The SUMO-specific protease SENP5 is required for cell division. Mol Cell Biol. 2006;26:4489-98 pubmed
    ..SUMOylation is reversible, and several mammalian homologs of the yeast SUMO-specific protease Ulp1, termed SENPs, have been identified...
  7. Haindl M, Harasim T, Eick D, Muller S. The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing. EMBO Rep. 2008;9:273-9 pubmed publisher
    ..Here, we show that the nucleolar SUMO-specific protease SENP3 is associated with nucleophosmin (NPM1), a crucial factor in ribosome biogenesis...
  8. Kuo M, den Besten W, Thomas M, Sherr C. Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3. Cell Cycle. 2008;7:3378-87 pubmed
    ..and subcellular localization of the p19(Arf) tumor suppressor protein and the SUMO-2/3 deconjugating protease Senp3 each depend upon their binding to the abundant nucleolar protein nucleophosmin (Npm/B23)...
  9. Yan S, Sun X, Xiang B, Cang H, Kang X, Chen Y, et al. Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90. EMBO J. 2010;29:3773-86 pubmed publisher
    ..We report here a novel client protein, the SUMO2/3 protease SENP3, that is sophisticatedly regulated by CHIP and Hsp90...

More Information

Publications63

  1. Han Y, Huang C, Sun X, Xiang B, Wang M, Yeh E, et al. SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress. J Biol Chem. 2010;285:12906-15 pubmed publisher
    ..Here, we show that low doses of hydrogen peroxide (H(2)O(2)) induce an increase of the SENP3 protein, which removes SUMO2/3 from promyelocytic leukemia (PML)...
  2. Huang C, Han Y, Wang Y, Sun X, Yan S, Yeh E, et al. SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. EMBO J. 2009;28:2748-62 pubmed publisher
    ..Here, we show that a modest increase of reactive oxygen species (ROS) regulates SENP3 stability and localization...
  3. Liu Z, Anderson B, Yan K, Dong W, Liao H, Shi P. Global and regional changes in exposure to extreme heat and the relative contributions of climate and population change. Sci Rep. 2017;7:43909 pubmed publisher
    ..We find that for the higher emission scenario (RCP8.5-SSP3), the global exposure increases nearly 30-fold by 2100...
  4. Iqbal M, Islam M, Hofstra N. The impact of socio-economic development and climate change on E. coli loads and concentrations in Kabul River, Pakistan. Sci Total Environ. 2019;650:1935-1943 pubmed publisher
    ..density growth, moderate urbanisation, slightly improved wastewater treatment, no manure treatment (based on SSP3, "Regional rivalry") and strong climate change (RCP8.5, high GHG emissions). Simulated E...
  5. Zhang Y, Zheng L, Wang C, Gu J, Xue S. SENP3 protects H9C2 cells from apoptosis triggered by H/R via STAT3 pathway. Eur Rev Med Pharmacol Sci. 2018;22:2778-2786 pubmed publisher
    To investigate whether SENP3 protects H9C2 cells from apoptosis triggered by H/R through the signal transducer and activator of transcription 3 (STAT3) pathway...
  6. Yu Z, Li H, Yan H, Yang Y, Zhang D, Huang L, et al. Expression and Cell Distribution of SENP3 in Brain Tissue After Traumatic Brain Injury in Mice: A Pilot Study. Cell Mol Neurobiol. 2015;35:733-40 pubmed publisher
    SUMO-specific proteases 3 (SENP3) is a member of the small ubiquitin-like modifier-specific protease family and deconjugates SUMO2/3 from protein substrates...
  7. Van Puijenbroek P, Bouwman A, Beusen A, Lucas P. Global implementation of two shared socioeconomic pathways for future sanitation and wastewater flows. Water Sci Technol. 2015;71:227-33 pubmed publisher
    ..SSP1 is a scenario that includes improvement of wastewater treatment and SSP3 does not include such improvement, with fewer investments and a higher population growth...
  8. Yu X, Lao Y, Teng X, Li S, Zhou Y, Wang F, et al. SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. Nat Commun. 2018;9:3157 pubmed publisher
    ..Here we show SUMO-specific protease 3 (SENP3) is a pivotal regulator of Treg cells that functions by controlling the SUMOylation and nuclear localization of ..
  9. Kebede A, Nicholls R, Allan A, Arto I, Cazcarro I, Fernandes J, et al. Applying the global RCP-SSP-SPA scenario framework at sub-national scale: A multi-scale and participatory scenario approach. Sci Total Environ. 2018;635:659-672 pubmed publisher
    ..5) combined with three SSP-based socio-economic scenarios (SSP2, SSP3, SSP5), we generate highly divergent and challenging scenario contexts across multiple scales against which ..
  10. Yang Y, Li H, Zhang X, Wang C, Sun Q, Li S, et al. Expression and cell distribution of SENP3 in the cerebral cortex after experimental subarachnoid hemorrhage in rats: a pilot study. Cell Mol Neurobiol. 2015;35:407-416 pubmed publisher
    ..Small ubiquitin-like modifier (SUMO)-specific proteases 3 (SENP3), a member of the SUMO-specific protease family, was identified as an isopeptidase that deconjugates SUMOylation (..
  11. Harupa A, Sack B, Lakshmanan V, Arang N, Douglass A, Oliver B, et al. SSP3 is a novel Plasmodium yoelii sporozoite surface protein with a role in gliding motility. Infect Immun. 2014;82:4643-53 pubmed publisher
    ..Here, we characterize a novel, conserved sporozoite surface protein (SSP3) in the rodent malaria parasite Plasmodium yoelii...
  12. Mendes A, Grou C, Azevedo J, Pinto M. Evaluation of the activity and substrate specificity of the human SENP family of SUMO proteases. Biochim Biophys Acta. 2016;1863:139-47 pubmed publisher
    ..We found that SENP1 is by far the most versatile and active SENP whereas SENP3 stands out as the least active of these enzymes...
  13. Huang C, Wu D, Khan F, Huo L. The SUMO Protease SENP3 Orchestrates G2-M Transition and Spindle Assembly in Mouse Oocytes. Sci Rep. 2015;5:15600 pubmed publisher
    ..b>SENP3 an important deSUMOylation protease has been intensively studied in ribosome biogenesis and oxidative stress...
  14. Wang M, Kroeze C, Strokal M, Ma L. Reactive nitrogen losses from China's food system for the shared socioeconomic pathways (SSPs). Sci Total Environ. 2017;605-606:884-893 pubmed publisher
    ..indicate that Nr losses from future food system in China are relatively low for SSP1 and SSP2, and relatively high for SSP3 and SSP4. In SSP5 Nr losses from China's food system are projected to be slightly lower than the level of today.
  15. Lao Y, Yang K, Wang Z, Sun X, Zou Q, Yu X, et al. DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages. J Biol Chem. 2018;293:3965-3980 pubmed publisher
    ..Previously, we demonstrated that SENP3 is a redox-sensitive SUMO2/3 protease...
  16. Wei B, Huang C, Liu B, Wang Y, Xia N, Fan Q, et al. Mitotic Phosphorylation of SENP3 Regulates DeSUMOylation of Chromosome-Associated Proteins and Chromosome Stability. Cancer Res. 2018;78:2171-2178 pubmed publisher
    ..Here, we demonstrate that precise phosphorylation of SENP3 during mitosis suppresses SENP3 deSUMOylation activity towards chromosome-associated proteins, including ..
  17. Wetzel F, Mittag S, Cano Cortina M, Wagner T, Kramer O, Niedenthal R, et al. SUMOylation regulates the intracellular fate of ZO-2. Cell Mol Life Sci. 2017;74:373-392 pubmed publisher
    ..show that ZO-2 associates with the E2 SUMO-conjugating enzyme Ubc9 and with SUMO-deconjugating proteases SENP1 and SENP3. In line with this, modification of ZO-2 by endogenous SUMO1 was detectable...
  18. Chowdhury S, Dey S, Smith K. Ambient PM2.5 exposure and expected premature mortality to 2100 in India under climate change scenarios. Nat Commun. 2018;9:318 pubmed publisher
    ..5 for all scenarios except the combination of RCP8.5 exposure and SSP3.
  19. Guo C, Wilkinson K, Evans A, Rubin P, Henley J. SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death. Sci Rep. 2017;7:43811 pubmed publisher
    ..DeSUMOylation of Drp1 by the enzyme SENP3 promotes cell death during reperfusion after ischaemia by enhancing Drp1 partitioning to the mitochondrial outer ..
  20. Nayak A, Reck A, Morsczeck C, Müller S. Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes. Epigenetics Chromatin. 2017;10:15 pubmed publisher
    ..Previously, we established that the SUMO isopeptidase SENP3 regulates chromatin assembly of the MLL1/2 histone methyltransferase complex at distinct HOX genes, ..
  21. Gao L, Zhao Y, He J, Yan Y, Xu L, Lin N, et al. The desumoylating enzyme sentrin-specific protease 3 contributes to myocardial ischemia reperfusion injury. J Genet Genomics. 2018;45:125-135 pubmed publisher
    Sentrin-specific protease 3 (SENP3), a member of the desumoylating enzyme family, is known as a redox sensor and could regulate multiple cellular signaling pathways...
  22. Wang D, Liu K, Kasper G, Lin Q, Hai J. Inhibition of SENP3 by URB597 ameliorates neurovascular unit dysfunction in rats with chronic cerebral hypoperfusion. Biomed Pharmacother. 2017;91:872-879 pubmed publisher
    ..SUMO-specific protease 3 (SENP3) is expressed in neurons, astrocytes, and microglia, and regulates a variety of cell events...
  23. Zhuo L, Mekonnen M, Hoekstra A. Consumptive water footprint and virtual water trade scenarios for China - With a focus on crop production, consumption and trade. Environ Int. 2016;94:211-223 pubmed publisher
    ..Four scenarios (S1-S4) are constructed by making use of three of IPCC's shared socio-economic pathways (SSP1-SSP3) and two of IPCC's representative concentration pathways (RCP 2.6 and RCP 8.5) and taking 2005 as the baseline year...
  24. Wang M, Sang J, Ren Y, Liu K, Liu X, Zhang J, et al. SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation. Protein Cell. 2016;7:63-77 pubmed publisher
    ..The present study investigated the role of SENP3 in the global protein turnover related to SUMO2/3-targeted ubiquitination and focused in particular on the SENP3 ..
  25. Cui W, Sun M, Galeva N, Williams T, Azuma Y, Staudinger J. SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes. Drug Metab Dispos. 2015;43:1316-25 pubmed publisher
    ..The SUMO modification of PXR is effectively antagonized by the SUMO protease sentrin protease (SENP) 2, whereas SENP3 and SENP6 proteases are highly active in the removal of SUMO2/3 chains...
  26. Yang Y, Li H, Zhang X, Li W, Huang L, Yu Z, et al. Inhibition of SENP3 by lentivirus induces suppression of apoptosis in experimental subarachnoid hemorrhage in rats. Brain Res. 2015;1622:270-8 pubmed publisher
    ..SUMO-specific proteases 3 (SENP3), a member of the small ubiquitin-like modifier specific protease family, was identified as an isopeptidase that ..
  27. Borris M, Leonhardt G, Marsalek J, Osterlund H, Viklander M. Source-Based Modeling Of Urban Stormwater Quality Response to the Selected Scenarios Combining Future Changes in Climate and Socio-Economic Factors. Environ Manage. 2016;58:223-37 pubmed publisher
    ..5) for two SSPs, the Sustainability and Security scenarios (SSP1 and SSP3), the TSS loads increased on average by 70 %...
  28. Kashiwaya K, Nakagawa H, Hosokawa M, Mochizuki Y, Ueda K, Piao L, et al. Involvement of the tubulin tyrosine ligase-like family member 4 polyglutamylase in PELP1 polyglutamylation and chromatin remodeling in pancreatic cancer cells. Cancer Res. 2010;70:4024-33 pubmed publisher
    ..We also identified the interaction of PELP1 with LAS1L and SENP3, components of the MLL1-WDR5 supercomplex involving chromatin remodeling...
  29. Raman N, Weir E, Muller S. The AAA ATPase MDN1 Acts as a SUMO-Targeted Regulator in Mammalian Pre-ribosome Remodeling. Mol Cell. 2016;64:607-615 pubmed publisher
    ..We previously identified the human PELP1-TEX10-WDR18 complex and the associated SUMO isopeptidase SENP3 as regulators of 60S maturation...
  30. Luo J, Gurung S, Lee L, Henley J, Wilkinson K, Guo C. Increased SUMO-2/3-ylation mediated by SENP3 degradation is protective against cadmium-induced caspase 3-dependent cytotoxicity. J Toxicol Sci. 2017;42:529-538 pubmed publisher
    ..Here, we show increased levels of SUMOylation and decreased levels of the SUMO deconjugating enzyme SENP3 in PC12 cells treated with the toxic heavy metal cadmium...
  31. Raman N, Nayak A, Muller S. mTOR signaling regulates nucleolar targeting of the SUMO-specific isopeptidase SENP3. Mol Cell Biol. 2014;34:4474-84 pubmed publisher
    ..One critical factor of 28S rRNA maturation is the SUMO-isopeptidase SENP3. SENP3 tightly interacts with the nucleolar scaffold protein NPM1 and is associated with nucleolar 60S ..
  32. Ren Y, Liu K, Wang M, Yu Y, Yang K, Chen Q, et al. De-SUMOylation of FOXC2 by SENP3 promotes the epithelial-mesenchymal transition in gastric cancer cells. Oncotarget. 2014;5:7093-104 pubmed
    ..Our previous study shows that SENP3, a redox-sensitive SUMO2/3-specific protease, accumulates in a variety of cancers, but whether SENP3 and ..
  33. Nayak A, Viale Bouroncle S, Morsczeck C, Muller S. The SUMO-specific isopeptidase SENP3 regulates MLL1/MLL2 methyltransferase complexes and controls osteogenic differentiation. Mol Cell. 2014;55:47-58 pubmed publisher
    ..We show that the SUMO-specific isopeptidase SENP3 controls H3K4 methylation by regulating histone-modifying SET1/MLL complexes...
  34. Guo C, Hildick K, Luo J, Dearden L, Wilkinson K, Henley J. SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia. EMBO J. 2013;32:1514-28 pubmed publisher
    ..Here, we demonstrate that the SUMO-2/3-specific protease SENP3 is degraded during oxygen/glucose deprivation (OGD), an in vitro model of ischaemia, via a pathway involving the ..
  35. Gregoire S, Yang X. Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors. Mol Cell Biol. 2005;25:2273-87 pubmed
    ..Opposing the action of class IIa deacetylases, the SUMO protease SENP3 reverses the sumoylation to augment the transcriptional and myogenic activities of MEF2...
  36. Messner S, Schuermann D, Altmeyer M, Kassner I, Schmidt D, Schär P, et al. Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function. FASEB J. 2009;23:3978-89 pubmed publisher
  37. Kunz K, Wagner K, Mendler L, Hölper S, Dehne N, Muller S. SUMO Signaling by Hypoxic Inactivation of SUMO-Specific Isopeptidases. Cell Rep. 2016;16:3075-3086 pubmed publisher
    ..demonstrate that in hypoxic cell extracts, the catalytic activity of SENP family members, in particular SENP1 and SENP3, is inhibited in a rapid and fully reversible process...
  38. Klein U, Haindl M, Nigg E, Muller S. RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin. Mol Biol Cell. 2009;20:410-8 pubmed publisher
    ..Moreover, the SUMO isopeptidase SENP3 is a specific interaction partner of Borealin and catalyzes the removal of SUMO2/3 from Borealin...
  39. Huang W, Ghisletti S, Saijo K, Gandhi M, Aouadi M, Tesz G, et al. Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Nature. 2011;470:414-8 pubmed publisher
    ..kinase II? (CaMKII?)-dependent phosphorylation of LXRs, leading to their deSUMOylation by the SUMO protease SENP3 and release from CORO2A...
  40. Castle C, Cassimere E, Denicourt C. LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis. Mol Biol Cell. 2012;23:716-28 pubmed publisher
    ..with PELP1, TEX10, and WDR18, the mammalian homologues of the budding yeast Rix1 complex, along with NOL9 and SENP3, to form a novel nucleolar complex that cofractionates with the 60S preribosomal subunit...
  41. Bialik P, Wozniak K. SUMO proteases as potential targets for cancer therapy. Postepy Hig Med Dosw (Online). 2017;71:997-1004 pubmed publisher
    ..Six SENP isoforms (SENP1, SENP2, SENP3, SENP5, SENP6 and SENP7) have been identified in mammals...
  42. Wang Y, Yang J, Yang K, Cang H, Huang X, Li H, et al. The biphasic redox sensing of SENP3 accounts for the HIF-1 transcriptional activity shift by oxidative stress. Acta Pharmacol Sin. 2012;33:953-63 pubmed publisher
    ..The interaction of p300 with HIF-1? or with SENP3, and the SUMO2/3 conjugation states of p300 were examined by coimmunoprecipitation...
  43. Zhou Z, Wang M, Li J, Xiao M, Chin Y, Cheng J, et al. SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer. Oncogene. 2016;35:5826-5838 pubmed publisher
    ..lines to a tobacco extract induced a rapid Y705 phosphorylation of STAT3 and a rapid increase in the SUMO protease SENP3 that depended on a simultaneous increase in reactive oxygen species...
  44. Witty J, Aguilar Martinez E, Sharrocks A. SENP1 participates in the dynamic regulation of Elk-1 SUMOylation. Biochem J. 2010;428:247-54 pubmed publisher
    ..Taken together, these results therefore reveal an important role for SENP1 in the regulation of Elk-1-mediated gene expression in response to mitogenic signalling cues. ..
  45. Yang M, Wu Y, Lu Y, Liu C, Sun J, Liao M, et al. Genome-wide scan identifies variant in TNFSF13 associated with serum IgM in a healthy Chinese male population. PLoS ONE. 2012;7:e47990 pubmed publisher
    ..05), but there was no significant interaction between smoking and the identified SNP (P>0.05). It is suggested that TNFSF13 may be a susceptibility gene affecting serum IgM levels in Chinese male population. ..
  46. Sun Z, Hu S, Luo Q, Ye D, Hu D, Chen F. Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation. Oncol Rep. 2013;29:1701-6 pubmed publisher
    ..As one of the crucial members of the SUMO system, SENP3 is essential for rRNA processing and cell proliferation...
  47. Hofstra N, Vermeulen L. Impacts of population growth, urbanisation and sanitation changes on global human Cryptosporidium emissions to surface water. Int J Hyg Environ Health. 2016;219:599-605 pubmed publisher
    ..SSP1* is the same as SSP1, but waste water treatment does not improve. SSP3 sees large population growth, moderate urbanisation and sanitation and waste water treatment fractions that are the ..
  48. Islam M, Iqbal M, Leemans R, Hofstra N. Modelling the impact of future socio-economic and climate change scenarios on river microbial water quality. Int J Hyg Environ Health. 2018;221:283-292 pubmed publisher
    ..Scenarios have been developed building on the most recent Shared Socio-economic Pathways: SSP1 and SSP3 and Representative Concentration Pathways: RCP4.5 and RCP8.5 in a matrix...
  49. Cheng J, Su M, Jin Y, Xi Q, Deng Y, Chen J, et al. Upregulation of SENP3/SMT3IP1 promotes epithelial ovarian cancer progression and forecasts poor prognosis. Tumour Biol. 2017;39:1010428317694543 pubmed publisher
  50. Stankovic Valentin N, Deltour S, Seeler J, Pinte S, Vergoten G, Guerardel C, et al. An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity. Mol Cell Biol. 2007;27:2661-75 pubmed
    ..mutation of the other conserved residue in the psiKXE consensus, E316A, or the overexpression of the deSUMOylase SSP3/SENP2. Furthermore, HIC1 is acetylated in vitro by P300/CBP...
  51. Nishida T, Yamada Y. The nucleolar SUMO-specific protease SMT3IP1/SENP3 attenuates Mdm2-mediated p53 ubiquitination and degradation. Biochem Biophys Res Commun. 2011;406:285-91 pubmed publisher
    ..Here, we show that a nucleolar SUMO-specific protease, SMT3IP1/SENP3, controls the p53-Mdm2 pathway...
  52. Nishida T, Yamada Y. SMT3IP1, a nucleolar SUMO-specific protease, deconjugates SUMO-2 from nucleolar and cytoplasmic nucleophosmin. Biochem Biophys Res Commun. 2008;374:382-7 pubmed publisher
    ..We characterized a nucleolar SUMO-specific protease, SMT3IP1, which has a preference for SUMO-2/3...
  53. Bhattacharjee J, Alahari S, Sallais J, Tagliaferro A, Post M, Caniggia I. Dynamic regulation of HIF1? stability by SUMO2/3 and SENP3 in the human placenta. Placenta. 2016;40:8-17 pubmed publisher
    ..HIF1A-SUMO2/3 associations peaked at 9-10 weeks, while its deSUMOylation by SENP3 was greatest at 10-12 weeks...
  54. Bouras T, Fu M, Sauve A, Wang F, Quong A, Perkins N, et al. SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem. 2005;280:10264-76 pubmed
    ..The SUMO-specific protease SSP3 relieved SIRT1 repression of p300. SSP3 antagonism of SIRT1 required the SUMO-deconjugating function of SSP3...