SEMA7A

Summary

Gene Symbol: SEMA7A
Description: semaphorin 7A (John Milton Hagen blood group)
Alias: CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, SEMAK1, SEMAL, semaphorin-7A, JMH blood group antigen, John Milton Hagen blood group H-Sema K1, john-Milton-Hargen human blood group Ag, sema K1, sema L, sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A (JMH blood group), sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, 7A, semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group), semaphorin-K1, semaphorin-L
Species: human
Products:     SEMA7A

Top Publications

  1. Xu X, Ng S, Wu Z, Nguyen D, Homburger S, Seidel Dugan C, et al. Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins. J Biol Chem. 1998;273:22428-34 pubmed
    ..We report here on the identification of semaphorin K1 (sema K1), the first semaphorin known to be associated with cell surfaces via a glycosylphosphatidylinositol ..
  2. Lange C, Liehr T, Goen M, Gebhart E, Fleckenstein B, Ensser A. New eukaryotic semaphorins with close homology to semaphorins of DNA viruses. Genomics. 1998;51:340-50 pubmed
    ..The respective genes were cloned and sequenced, and they were termed H-Sema-L and M-Sema-L (HGMW-approved symbols SEMAL and Semal, respectively). A multiply spliced mRNA of 3...
  3. Yamada A, Kubo K, Takeshita T, Harashima N, Kawano K, Mine T, et al. Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108. J Immunol. 1999;162:4094-100 pubmed
    b>CDw108, also known as the John-Milton-Hagen human blood group Ag, is an 80-kDa glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein that is preferentially expressed on activated lymphocytes and E...
  4. Pasterkamp R, Peschon J, Spriggs M, Kolodkin A. Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. Nature. 2003;424:398-405 pubmed
    ..We show here that semaphorin 7A (Sema7A), a membrane-anchored member of the semaphorin family of guidance proteins previously known for its ..
  5. Gras C, Eiz Vesper B, Seltsam A, Immenschuh S, Blasczyk R, Figueiredo C. Semaphorin 7A protein variants differentially regulate T-cell activity. Transfusion. 2013;53:270-83 pubmed publisher
    b>Semaphorin 7A (Sema7A) carries the John-Milton-Hagen human blood group antigen on red blood cells and shows molecular diversity...
  6. Liu H, Juo Z, Shim A, Focia P, Chen X, Garcia K, et al. Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1. Cell. 2010;142:749-61 pubmed publisher
    ..b>Sema7A acts as both an immune and a neural Semaphorin through PlexinC1, and A39R is a Sema7A mimic secreted by smallpox ..
  7. Scott G, McClelland L, Fricke A, Fender A. Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is a potential tumor suppressor for melanoma progression. J Invest Dermatol. 2009;129:954-63 pubmed publisher
    ..Our previous data showed that semaphorin 7A (Sema7A), a protein involved in axon guidance, stimulates melanocyte adhesion and dendricity through opposing ..
  8. Angelisova P, Drbal K, Cerny J, Hilgert I, Horejsi V. Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules. Immunobiology. 1999;200:234-45 pubmed
    ..In addition to the previously described identity of CDw108 with the JMH blood group antigen, we demonstrate here its identity to the previously described glycoprotein recognized by monoclonal ..
  9. Holmes S, Downs A, Fosberry A, Hayes P, Michalovich D, Murdoch P, et al. Sema7A is a potent monocyte stimulator. Scand J Immunol. 2002;56:270-5 pubmed
    b>Sema7A is a recently described member of the semaphorin family that is associated with the cell surface via a glycophosphatidylinositol linkage. This study examined the mRNA expression and biological properties of this protein...

More Information

Publications65

  1. Koh J, Oh B, Lee J, Lee J, Kimm K, Kim G, et al. Association study of semaphorin 7a (sema7a) polymorphisms with bone mineral density and fracture risk in postmenopausal Korean women. J Hum Genet. 2006;51:112-7 pubmed
    ..b>Semaphorin 7a (SEMA7A), a recently described member of the semaphorin family, has been shown to play a critical role in the ..
  2. Seltsam A, Strigens S, Levene C, Yahalom V, Moulds M, Moulds J, et al. The molecular diversity of Sema7A, the semaphorin that carries the JMH blood group antigens. Transfusion. 2007;47:133-46 pubmed
    Semaphorin 7A (Sema7A), the protein that carries the JMH blood group antigen, is involved in immune responses and plays an important role in axon growth and guidance...
  3. Suzuki K, Okuno T, Yamamoto M, Pasterkamp R, Takegahara N, Takamatsu H, et al. Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. Nature. 2007;446:680-4 pubmed
    ..b>Semaphorin 7A (Sema7A; also known as CD108), which is a glycosylphosphatidylinositol-anchored semaphorin, promotes axon ..
  4. Scott G, McClelland L, Fricke A. Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins. J Invest Dermatol. 2008;128:151-61 pubmed
    ..In this study, we describe the function of Semaphorin 7a, a membrane-bound Semaphorin known to stimulate neurite outgrowth, on human melanocytes...
  5. Zhou C, Niu Y, Xu H, Li Z, Wang T, Yang W, et al. Mutation profiles and clinical characteristics of Chinese males with isolated hypogonadotropic hypogonadism. Fertil Steril. 2018;110:486-495.e5 pubmed publisher
    ..In addition, variants were identified in 36 candidate genes, and EGFR, ERBB4, PAX6, IGF1, SEMA4D, and SEMA7A should be prioritized for further research and genetic testing in IHH...
  6. Sakai Takemura F, Narita A, Masuda S, Wakamatsu T, Watanabe N, Nishiyama T, et al. Premyogenic progenitors derived from human pluripotent stem cells expand in floating culture and differentiate into transplantable myogenic progenitors. Sci Rep. 2018;8:6555 pubmed publisher
    ..hiPSC-derived myogenic progenitors were enriched in the CD57(-) CD108(-) CD271(+) ERBB3(+) cell fraction, and their differentiation was greatly promoted by TGF-β inhibitors...
  7. Haridoss S, Yovchev M, Schweizer H, Megherhi S, Beecher M, Locker J, et al. Activin A is a prominent autocrine regulator of hepatocyte growth arrest. Hepatol Commun. 2017;1:852-870 pubmed publisher
    ..g., ADAM metallopeptidase domain 12 [Adam12], semaphorin 7A [Sema7a], LIM and cysteine-rich domains-1 [Lmcd1], DAB2, clathrin adaptor protein [Dab2])...
  8. Chucair Elliott A, Zheng M, Carr D. Degeneration and regeneration of corneal nerves in response to HSV-1 infection. Invest Ophthalmol Vis Sci. 2015;56:1097-107 pubmed publisher
    ..b>Semaphorin 7A (SEMA 7A) neutralizing antibody or isotype control was subconjunctivally administered to infected mice...
  9. Blom L, Martel B, Larsen L, Hansen C, Christensen M, Juel Berg N, et al. The immunoglobulin superfamily member CD200R identifies cells involved in type 2 immune responses. Allergy. 2017;72:1081-1090 pubmed publisher
    ..analysis of >300 surface proteins enabled identification of IL-4-upregulated surface proteins, such as CD90, CD108, CD109, and CD200R (CD200R1)...
  10. Seltsam A, Grueger D, Blasczyk R, Flegel W. Easy identification of antibodies to high-prevalence Scianna antigens and detection of admixed alloantibodies using soluble recombinant Scianna protein. Transfusion. 2009;49:2090-6 pubmed publisher
    ..A mixture of Scianna and JMH proteins allowed detecting a common antibody despite the presence of antibodies to high-prevalence antigens of the ..
  11. Staubach S, Müller S, Pekmez M, Hanisch F. Classical Galactosemia: Insight into Molecular Pathomechanisms by Differential Membrane Proteomics of Fibroblasts under Galactose Stress. J Proteome Res. 2017;16:516-527 pubmed publisher
    ..A series of proteins showed opposite fold-changes in the two cell models, whereas others fluctuated in only one of the two models. ..
  12. Fong C, Subramanian A, Biswas A, Bongso A. Freezing of Fresh Wharton's Jelly From Human Umbilical Cords Yields High Post-Thaw Mesenchymal Stem Cell Numbers for Cell-Based Therapies. J Cell Biochem. 2016;117:815-27 pubmed publisher
    ..Post-thaw WJ and WJSC produced significantly greater CD24(+) and CD108(+) fluorescence intensities and significantly lower CD40(+) contaminants...
  13. Liu T, Guo J, Wang H, Xu X. Semaphorin-7A contributes to growth, migration and invasion of oral tongue squamous cell carcinoma through TGF-β-mediated EMT signaling pathway. Eur Rev Med Pharmacol Sci. 2018;22:1035-1043 pubmed publisher
    ..Semaphorin-7A promoted growth and migration of OTSCC by regulating TGF-β-induced EMT signaling pathway in OTSCC cells, which provided a new interconnection between the Semaphorin-7A and TGF-β-induced EMT signaling pathway. ..
  14. He M, Bian Z. Expression of hypoxia-induced semaphorin 7A correlates with the severity of inflammation and osteoclastogenesis in experimentally induced periapical lesions. Arch Oral Biol. 2017;75:114-119 pubmed publisher
    ..of experimentally induced rat periapical lesions, and to derive correlations between hypoxia-induced Semaphorin 7A (Sema7a) expression, severity of inflammation, and osteoclastogenesis in the lesions...
  15. Gutiérrez Franco A, Eixarch H, Costa C, Gil V, Castillo M, Calvo Barreiro L, et al. Semaphorin 7A as a Potential Therapeutic Target for Multiple Sclerosis. Mol Neurobiol. 2017;54:4820-4831 pubmed publisher
    b>Semaphorin 7A (sema7A) is classified as an immune semaphorin with dual functions in the immune system and in the central nervous system (CNS)...
  16. Gutiérrez Franco A, Costa C, Eixarch H, Castillo M, Medina Rodríguez E, Bribián A, et al. Differential expression of sema3A and sema7A in a murine model of multiple sclerosis: Implications for a therapeutic design. Clin Immunol. 2016;163:22-33 pubmed publisher
    We characterised the expression of semaphorin (sema)3A, sema7A and their receptors in the immune and the central nervous system (CNS) at different stages of experimental autoimmune encephalomyelitis (EAE)...
  17. Pacelli C, Giguère N, Bourque M, Lévesque M, Slack R, Trudeau L. Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons. Curr Biol. 2015;25:2349-60 pubmed publisher
    ..Furthermore, we demonstrate that reducing axonal arborization by acting on axon guidance pathways with Semaphorin 7A reduces in parallel the basal rate of mitochondrial OXPHOS and the vulnerability of nigral DA neurons to the ..
  18. Kalaani J, Roche J, Hamade E, Badran B, Jaber M, Gaillard A, et al. Axon guidance molecule expression after cell therapy in a mouse model of Parkinson's disease. Restor Neurol Neurosci. 2016;34:877-895 pubmed
    ..Moreover, we highlight a possible new role for semaphorin 7A in this repair...
  19. Esnault S, Torr E, Bernau K, Johansson M, Kelly E, Sandbo N, et al. Endogenous Semaphorin-7A Impedes Human Lung Fibroblast Differentiation. PLoS ONE. 2017;12:e0170207 pubmed publisher
    ..Therefore, endogenous and exogenous semaphorin-7A may have opposite effects on the fibroblast phenotype. ..
  20. Lee Y, Blount K, Dai F, Thompson S, Scher J, Bitterman S, et al. Semaphorin 7A in circulating regulatory T cells is increased in autosomal-dominant polycystic kidney disease and decreases with tolvaptan treatment. Clin Exp Nephrol. 2018;22:906-916 pubmed publisher
    b>Semaphorin 7A (SEMA7A) is an immunomodulating protein implicated in lung and liver fibrosis...
  21. Arvidsson G, Henriksson J, Sander B, Wright A. Mixed-species RNAseq analysis of human lymphoma cells adhering to mouse stromal cells identifies a core gene set that is also differentially expressed in the lymph node microenvironment of mantle cell lymphoma and chronic lymphocytic leukemia patient. Haematologica. 2018;103:666-678 pubmed publisher
    ..we suggest a core set of genes (CCL3, CCL4, DUSP4, ETV5, ICAM1, IL15RA, IL21R, IL4I1, MFSD2A, NFKB1, NFKBIE, SEMA7A, TMEM2) characteristic of cells undergoing cell-adhesion-mediated microenvironment signaling in mantle cell ..
  22. Hu S, Liu Y, You T, Heath J, Xu L, Zheng X, et al. Vascular Semaphorin 7A Upregulation by Disturbed Flow Promotes Atherosclerosis Through Endothelial ?1 Integrin. Arterioscler Thromb Vasc Biol. 2018;38:335-343 pubmed publisher
    ..Here, we investigate the role of Sema7A (semaphorin 7A) in atherosclerosis and its underlying mechanism...
  23. Zhang Y, Hu J, Zhang J, Zhou X, Li X, Gu C, et al. Genome-wide association study identifies multiple susceptibility loci for craniofacial microsomia. Nat Commun. 2016;7:10605 pubmed publisher
    ..The above 13 associated loci, harboured by candidates of ROBO1, GATA3, GBX2, FGF3, NRP2, EDNRB, SHROOM3, SEMA7A, PLCD3, KLF12 and EPAS1, are found to be enriched for genes involved in neural crest cell (NCC) development and ..
  24. Jongbloets B, Lemstra S, Schellino R, Broekhoven M, Parkash J, Hellemons A, et al. Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors. Nat Commun. 2017;8:14666 pubmed publisher
    The guidance protein Semaphorin7A (Sema7A) is required for the proper development of the immune and nervous systems. Despite strong expression in the mature brain, the role of Sema7A in the adult remains poorly defined...
  25. Wang Y, Viennet C, Robin S, Berthon J, He L, Humbert P. Precise role of dermal fibroblasts on melanocyte pigmentation. J Dermatol Sci. 2017;88:159-166 pubmed publisher
    ..and indirectly through neighboring cells by secreting a large number of cytokines (SCF), proteins (DKK1, sFRP, Sema7a, CCN, FAP-?) and growth factors (KGF, HGF, bFGF, NT-3, NRG-1, TGF-?) which bind to receptors and modulate ..
  26. Esnault S, Kelly E, Shen Z, Johansson M, Malter J, Jarjour N. IL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human Eosinophils. J Immunol. 2015;195:2529-39 pubmed publisher
    ..These observations identify IL-3 and its downstream intracellular signals as novel targets that should be considered to modulate eosinophil functions. ..
  27. Mizutani N, Nabe T, Yoshino S. Semaphorin 7A plays a critical role in IgE-mediated airway inflammation in mice. Eur J Pharmacol. 2015;764:149-56 pubmed publisher
    ..Here, we investigated whether semaphorin 7A (SEMA7A) is related to IgE-mediated neutrophilic inflammation in mice...
  28. Roth J, Köhler D, Schneider M, Granja T, Rosenberger P. Semaphorin 7A Aggravates Pulmonary Inflammation during Lung Injury. PLoS ONE. 2016;11:e0146930 pubmed publisher
    ..Recent work has demonstrated that the guidance protein semaphorin 7A (SEMA7A) influences the migration of neutrophils into hypoxic tissue sites, yet, its role during lung injury ..
  29. Seltsam A, Agaylan A, Grueger D, Meyer O, Blasczyk R, Salama A. Rapid detection of JMH antibodies with recombinant Sema7A (CD108) protein and the particle gel immunoassay. Transfusion. 2008;48:1151-5 pubmed publisher
    ..Here, a novel method is described for detection of anti-JMH with particles coated with recombinant semaphorin 7A (Sema7A, CD108), the protein that carries the JMH blood group antigens...
  30. Känsäkoski J, Fagerholm R, Laitinen E, Vaaralahti K, Hackman P, Pitteloud N, et al. Mutation screening of SEMA3A and SEMA7A in patients with congenital hypogonadotropic hypogonadism. Pediatr Res. 2014;75:641-4 pubmed publisher
    ..SEMA3A was recently implicated in the etiology of the disorder, and Sema7A-deficient mice have a reduced number of GnRH neurons in their brains...
  31. Esnault S, Kelly E, Johansson M, Liu L, Han S, Akhtar M, et al. Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines. Clin Immunol. 2014;150:90-100 pubmed publisher
    b>Semaphorin 7A (sema7a) plays a major role in TGF-?1-induced lung fibrosis...
  32. Hu Y, Malone J, Fagan A, Townsend R, Holtzman D. Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid. Mol Cell Proteomics. 2005;4:2000-9 pubmed
    ..These results validate our method of identifying differences in proteomic profiles of CSF samples and have important implications for the design of CSF biomarker studies for AD and other central nervous system disorders. ..
  33. Jaimes Y, Gras C, Goudeva L, Buchholz S, Eiz Vesper B, Seltsam A, et al. Semaphorin 7A inhibits platelet production from CD34+ progenitor cells. J Thromb Haemost. 2012;10:1100-8 pubmed publisher
    The multifunctional protein semaphorin 7A (Sema7A) may have regulatory effects on blood cell differentiation via its receptors ?1-integrin and plexin C1...
  34. Kamata M, Tada Y, Uratsuji H, Kawashima T, Asano Y, Sugaya M, et al. Semaphorin 7A on keratinocytes induces interleukin-8 production by monocytes. J Dermatol Sci. 2011;62:176-82 pubmed publisher
    b>Semaphorin 7A (Sema7A) expressed on activated T cells stimulates cytokine production in monocytes through its receptor, ?1?1 integrin...
  35. Uesaka N, Kano M. Presynaptic Mechanisms Mediating Retrograde Semaphorin Signals for Climbing Fiber Synapse Elimination During Postnatal Cerebellar Development. Cerebellum. 2018;17:17-22 pubmed publisher
    ..Importantly, we have recently uncovered that Semaphorin3A (Sema3A) and Semaphorin7A (Sema7A) derived from postsynaptic PCs act retrogradely onto presynaptic CFs and regulate CF synapse elimination...
  36. Black S, Nelson A, Gurule N, Futscher B, Lyons T. Semaphorin 7a exerts pleiotropic effects to promote breast tumor progression. Oncogene. 2016;35:5170-8 pubmed publisher
    ..drives breast tumor progression is of utmost importance for blocking tumor metastasis; we have identified that semaphorin 7a is a potent driver of ductal carcinoma in situ (DCIS) progression...
  37. Chabrat A, Brisson G, Doucet Beaupré H, Salesse C, Schaan Profes M, Dovonou A, et al. Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation. Nat Commun. 2017;8:933 pubmed publisher
    ..We also found that Sema7a/Plxnc1 interactions are responsible for the segregation of nigrostriatal and mesolimbic dopaminergic pathways...
  38. Vitalis T, Dauphinot L, Gressens P, Potier M, Mariani J, Gaspar P. ROR? Coordinates Thalamic and Cortical Maturation to Instruct Barrel Cortex Development. Cereb Cortex. 2017;:1-14 pubmed publisher
    ..Microarray analyses revealed that Sema7a, Neph, and Adcy8 are ROR? regulated genes that could be implicated in TCA and cortical maturation...
  39. Tamagnone L, Artigiani S, Chen H, He Z, Ming G, Song H, et al. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell. 1999;99:71-80 pubmed
    ..for the transmembrane semaphorin Sema4D (CD100), and plexin-C1 is a receptor for the GPI-anchored semaphorin Sema7A (Sema-K1)...
  40. Chen X, Chen P, He X. Expression and Purification of Class 7 Semaphorin and Its PlexinC1 Receptor Using Baculovirus-Mediated Mammalian Cell Gene Transduction. Methods Mol Biol. 2017;1493:41-56 pubmed
    ..Here, we describe the expression of class 7 semaphorin (Sema7A) and the extracellular domain of its receptors PlexinC1, using the baculovirus-mediated mammalian cell gene ..
  41. Costa C, Martínez Sáez E, Gutiérrez Franco A, Eixarch H, Castro Z, Ortega Aznar A, et al. Expression of semaphorin 3A, semaphorin 7A and their receptors in multiple sclerosis lesions. Mult Scler. 2015;21:1632-43 pubmed publisher
    Studies in multiple sclerosis (MS) and in experimental models point to a critical role of semaphorin (sema)3A and sema7A in MS pathogenesis...
  42. Kang H, Lee C, Homer R, Elias J. Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis. J Exp Med. 2007;204:1083-93 pubmed
    ..They also demonstrate that the effects of SEMA 7A are not specific for transgenic TGF-beta(1), highlighting the importance of these findings for other fibrotic stimuli. ..
  43. Bartholdson S, Bustamante L, Crosnier C, Johnson S, Lea S, Rayner J, et al. Semaphorin-7A is an erythrocyte receptor for P. falciparum merozoite-specific TRAP homolog, MTRAP. PLoS Pathog. 2012;8:e1003031 pubmed publisher
    ..Here, we identify the GPI-linked protein Semaphorin-7A (CD108) as an erythrocyte receptor for the P...
  44. Lazova R, Gould Rothberg B, Rimm D, Scott G. The semaphorin 7A receptor Plexin C1 is lost during melanoma metastasis. Am J Dermatopathol. 2009;31:177-81 pubmed publisher
    ..b>Semaphorin 7A (Sema7A) is a membrane-linked semaphorin that is expressed by human keratinocytes, and we have shown that ..
  45. Xie J, Wang H. Semaphorin 7A as a potential immune regulator and promising therapeutic target in rheumatoid arthritis. Arthritis Res Ther. 2017;19:10 pubmed publisher
    b>Semaphorin 7A (Sema7A) is expressed by several different classes of lymphoid and myeloid cells and is a potent immunomodulator...
  46. Mine T, Harada K, Matsumoto T, Yamana H, Shirouzu K, Itoh K, et al. CDw108 expression during T-cell development. Tissue Antigens. 2000;55:429-36 pubmed
    ..0% or 89.3% similarity at the nucleotide or amino acid level, respectively) or identical to the murine semaphorin K1/Sema7A...
  47. Richard M, St Laurent J, Perreault J, Long A, St Louis M. A new SEMA7A variant found in Native Americans with alloantibody. Vox Sang. 2011;100:322-6 pubmed publisher
    John Milton Hagen (JMH) antigens are carried by Semaphorin 7A that plays important roles in the nervous system and the immune responses. Its role on the erythrocytes is unclear...
  48. Wu X, Meng Y, Wang C, Yue Y, Dong C, Xiong S. Semaphorin7A aggravates coxsackievirusB3-induced viral myocarditis by increasing ?1?1-integrin macrophages and subsequent enhanced inflammatory response. J Mol Cell Cardiol. 2017;114:48-57 pubmed publisher
    Semaphorin7A (Sema7A) has been reported to play various roles in nerve axon growth, tumor suppression, and tissue remodeling, as well as regulation of intestinal inflammation diseases...
  49. Garcia Areas R, Libreros S, Simoes M, Castro Silva C, Gazaniga N, Amat S, et al. Suppression of tumor-derived Semaphorin 7A and genetic ablation of host-derived Semaphorin 7A impairs tumor progression in a murine model of advanced breast carcinoma. Int J Oncol. 2017;51:1395-1404 pubmed publisher
    ..Among them, we have identified axonal guidance molecule Semaphorin 7A (SEMA7A) in breast cancer...
  50. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, et al. Semaphorin 7A contributes to TGF-β-mediated liver fibrogenesis. Am J Pathol. 2013;183:820-30 pubmed publisher
    Semaphorin7A (SEMA7A) is a membrane-anchored protein involved in immune and inflammatory responses, exerting an effect on pulmonary fibrosis. Thus, we aimed to investigate the role of SEMA7A in hepatic fibrosis...
  51. Cantó E, Tintoré M, Villar L, Borrás E, Alvarez Cermeño J, Chiva C, et al. Validation of semaphorin 7A and ala-β-his-dipeptidase as biomarkers associated with the conversion from clinically isolated syndrome to multiple sclerosis. J Neuroinflammation. 2014;11:181 pubmed publisher
    ..fluid (CSF) samples, we proposed apolipoprotein AI, apolipoprotein AIV, vitronectin, plasminogen, semaphorin 7A, and ala-β-his-dipeptidase as candidate biomarkers associated with the conversion to clinically definite ..
  52. Pham T, He J, Kakazu A, Jun B, Bazan N, Bazan H. Defining a mechanistic link between pigment epithelium-derived factor, docosahexaenoic acid, and corneal nerve regeneration. J Biol Chem. 2017;292:18486-18499 pubmed publisher
    ..free DHA led to enhanced docosanoid synthesis and induction of bdnf, ngf, and the axon growth promoter semaphorin 7a (sema7a), and as a consequence, their products appeared in the mouse tears...
  53. van Rijn A, Paulis L, Te Riet J, Vasaturo A, Reinieren Beeren I, van der Schaaf A, et al. Semaphorin 7A Promotes Chemokine-Driven Dendritic Cell Migration. J Immunol. 2016;196:459-68 pubmed publisher
    ..Based on a large-scale proteome analysis of maturing DCs, we identified the GPI-anchored protein semaphorin 7A (Sema7A) as being highly expressed on activated primary myeloid and plasmacytoid DCs in human and mouse...
  54. Fayyad Kazan M, Najar M, Fayyad Kazan H, Raicevic G, Lagneaux L. Identification and Evaluation of New Immunoregulatory Genes in Mesenchymal Stromal Cells of Different Origins: Comparison of Normal and Inflammatory Conditions. Med Sci Monit Basic Res. 2017;23:87-96 pubmed
    ..RESULTS FGL2, GAL, SEMA4D, SEMA7A, and IDO1 genes appeared to be differentially transcribed in the different MSC populations...
  55. Maurin J, Delorme G, Machuca Gayet I, Couble M, Magloire H, Jurdic P, et al. Odontoblast expression of semaphorin 7A during innervation of human dentin. Matrix Biol. 2005;24:232-8 pubmed
    b>Semaphorin 7A (SEMA 7A) is a membrane-anchored member of the semaphorin family of guidance proteins, previously identified in the immune system...
  56. Morote García J, Napiwotzky D, Kohler D, Rosenberger P. Endothelial Semaphorin 7A promotes neutrophil migration during hypoxia. Proc Natl Acad Sci U S A. 2012;109:14146-51 pubmed publisher
    ..Previously unknown, we report here the expression and induction of semaphorin 7A (SEMA7A) on endothelium through hypoxia-inducible factor 1? during hypoxia...