SEMA7A

Summary

Gene Symbol: SEMA7A
Description: semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
Alias: CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, SEMAK1, SEMAL, JMH blood group antigen, John Milton Hagen blood group H-Sema K1, john-Milton-Hargen human blood group Ag, sema K1, sema L, sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A (JMH blood group), sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, 7A, semaphorin K1, semaphorin L, semaphorin-7A, semaphorin-K1, semaphorin-L
Species: human

Top Publications

  1. ncbi Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins
    X Xu
    Exelixis Pharmaceuticals, Inc, South San Francisco, California 94080, USA
    J Biol Chem 273:22428-34. 1998
  2. ncbi Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins
    Glynis A Scott
    Department of Dermatology and Pathology, University of Rochester School of Medicine, Rochester, New York 14618, USA
    J Invest Dermatol 128:151-61. 2008
  3. ncbi The molecular diversity of Sema7A, the semaphorin that carries the JMH blood group antigens
    Axel Seltsam
    Institute for Transfusion Medicine, Hanover Medical School, Hanover, Germany
    Transfusion 47:133-46. 2007
  4. ncbi Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules
    P Angelisova
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Immunobiology 200:234-45. 1999
  5. ncbi Semaphorin 7A promotes axon outgrowth through integrins and MAPKs
    R Jeroen Pasterkamp
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Nature 424:398-405. 2003
  6. ncbi Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin
    Kazuhiro Suzuki
    Department of Molecular Immunology and CREST Program of JST, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nature 446:680-4. 2007
  7. ncbi Sema7A is a potent monocyte stimulator
    S Holmes
    Oxford GlycoSciences, Adbingdon, Oxon, UK
    Scand J Immunol 56:270-5. 2002
  8. ncbi Association study of semaphorin 7a (sema7a) polymorphisms with bone mineral density and fracture risk in postmenopausal Korean women
    Jung Min Koh
    Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, 44 2, Samduk 2 ga, Jung Gu, 700 412 Daegu, Republic of Korea
    J Hum Genet 51:112-7. 2006
  9. ncbi New eukaryotic semaphorins with close homology to semaphorins of DNA viruses
    C Lange
    Institut fur Klinische und Molekulare Virologie, Universitat Erlangen Nurnberg, Schlossgarten 4, Erlangen, 91054, Germany
    Genomics 51:340-50. 1998
  10. ncbi Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108
    A Yamada
    Cancer Vaccine Development Division, Kurume University Research Center for Innovative Cancer Therapy, Department of Immunology, Japan
    J Immunol 162:4094-100. 1999

Research Grants

Scientific Experts

  • G A Scott
  • Hameeda Sultana
  • GEORGE DOUGLAS LEIKAUF
  • Lina Bofill
  • Kimihiko Orito
  • Shikha Snigdha
  • Samuel R Mathias
  • Axel Seltsam
  • R Jeroen Pasterkamp
  • Sandra Verstraelen
  • L Tamagnone
  • S Holmes
  • Kyogo Itoh
  • Jonathan Holmes
  • S Molica
  • Daniel M Bernstein
  • Zheng Zheng Bao
  • BERNARD FOGEL
  • Emmalee Bandstra
  • JOSE STRAUSS
  • Marilyn Telen
  • Stuart Toledano
  • DAVID MATTHES
  • Linda A Sherman
  • George W Huntley
  • Atsushi Kumanogoh
  • Shizue Ohsawa
  • Sujin Kang
  • Takuro Maruyama
  • Kazuhiro Suzuki
  • Bart C Jongbloets
  • Herena Eixarch
  • Yan Zheng
  • Grace E Linder
  • William D Andrews
  • Ramon Garcia-Areas
  • J Galicia-Carreón
  • Christiane Gras
  • Samuele De Minicis
  • Ronald A Reilkoff
  • Guillaume Delorme
  • Julio César Morote-García
  • Pilar L Magoulas
  • S Josefin Bartholdson
  • Abed Namavari
  • J Xiao
  • Maryline Allegra
  • Thomas Russell
  • Y Jaimes
  • Rainer Blasczyk
  • Mridu Gulati
  • Xueyan Peng
  • C Bhargava
  • Okan Ozturk
  • Jin Hong Chang
  • Sandeep Jain
  • Karen P Fong
  • Akiko Fukunishi
  • Ramon C Ghanem
  • Catherine A Formolo
  • Ye Gan
  • Andrea Messina
  • Masahiro Kamata
  • M Richard
  • Andrea Mönster
  • Marcel A Kopp
  • Heli Liu
  • Hiroshi Ishii
  • Robert J Homer
  • Jack A Elias
  • Hiroki Yoshida
  • Hyota Takamatsu
  • Noriko Takegahara
  • Masayuki Miura
  • Nobuhiko Yamamoto
  • Shun Hamada
  • Tatsusada Okuno
  • Amber Y Spencer
  • Rossitza Lazova
  • Thore C Brink
  • Hye Ryun Kang
  • Agnieszka K Czopik
  • Jung Min Koh
  • Choong Won Kim
  • Eva Marie Yang Moresco
  • Yan Hu
  • Pierre Jurdic
  • Irma Machuca-Gayet
  • Jean Christophe Maurin
  • T Mine

Detail Information

Publications73

  1. ncbi Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins
    X Xu
    Exelixis Pharmaceuticals, Inc, South San Francisco, California 94080, USA
    J Biol Chem 273:22428-34. 1998
    ..We report here on the identification of semaphorin K1 (sema K1), the first semaphorin known to be associated with cell surfaces via a glycosylphosphatidylinositol ..
  2. ncbi Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins
    Glynis A Scott
    Department of Dermatology and Pathology, University of Rochester School of Medicine, Rochester, New York 14618, USA
    J Invest Dermatol 128:151-61. 2008
    ..In this study, we describe the function of Semaphorin 7a, a membrane-bound Semaphorin known to stimulate neurite outgrowth, on human melanocytes...
  3. ncbi The molecular diversity of Sema7A, the semaphorin that carries the JMH blood group antigens
    Axel Seltsam
    Institute for Transfusion Medicine, Hanover Medical School, Hanover, Germany
    Transfusion 47:133-46. 2007
    Semaphorin 7A (Sema7A), the protein that carries the JMH blood group antigen, is involved in immune responses and plays an important role in axon growth and guidance...
  4. ncbi Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules
    P Angelisova
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Immunobiology 200:234-45. 1999
    ..In addition to the previously described identity of CDw108 with the JMH blood group antigen, we demonstrate here its identity to the previously described glycoprotein recognized by monoclonal ..
  5. ncbi Semaphorin 7A promotes axon outgrowth through integrins and MAPKs
    R Jeroen Pasterkamp
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Nature 424:398-405. 2003
    ..We show here that semaphorin 7A (Sema7A), a membrane-anchored member of the semaphorin family of guidance proteins previously known for its ..
  6. ncbi Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin
    Kazuhiro Suzuki
    Department of Molecular Immunology and CREST Program of JST, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nature 446:680-4. 2007
    ..b>Semaphorin 7A (Sema7A; also known as CD108), which is a glycosylphosphatidylinositol-anchored semaphorin, promotes axon ..
  7. ncbi Sema7A is a potent monocyte stimulator
    S Holmes
    Oxford GlycoSciences, Adbingdon, Oxon, UK
    Scand J Immunol 56:270-5. 2002
    b>Sema7A is a recently described member of the semaphorin family that is associated with the cell surface via a glycophosphatidylinositol linkage. This study examined the mRNA expression and biological properties of this protein...
  8. ncbi Association study of semaphorin 7a (sema7a) polymorphisms with bone mineral density and fracture risk in postmenopausal Korean women
    Jung Min Koh
    Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, 44 2, Samduk 2 ga, Jung Gu, 700 412 Daegu, Republic of Korea
    J Hum Genet 51:112-7. 2006
    ..b>Semaphorin 7a (SEMA7A), a recently described member of the semaphorin family, has been shown to play a critical role in the ..
  9. ncbi New eukaryotic semaphorins with close homology to semaphorins of DNA viruses
    C Lange
    Institut fur Klinische und Molekulare Virologie, Universitat Erlangen Nurnberg, Schlossgarten 4, Erlangen, 91054, Germany
    Genomics 51:340-50. 1998
    ..The respective genes were cloned and sequenced, and they were termed H-Sema-L and M-Sema-L (HGMW-approved symbols SEMAL and Semal, respectively). A multiply spliced mRNA of 3...
  10. ncbi Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108
    A Yamada
    Cancer Vaccine Development Division, Kurume University Research Center for Innovative Cancer Therapy, Department of Immunology, Japan
    J Immunol 162:4094-100. 1999
    b>CDw108, also known as the John-Milton-Hagen human blood group Ag, is an 80-kDa glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein that is preferentially expressed on activated lymphocytes and E...
  11. doi Semaphorin 7A contributes to TGF-β-mediated liver fibrogenesis
    Samuele De Minicis
    Department of Gastroenterology, Polytechnic University of Marche, Ancona, Italy
    Am J Pathol 183:820-30. 2013
    Semaphorin7A (SEMA7A) is a membrane-anchored protein involved in immune and inflammatory responses, exerting an effect on pulmonary fibrosis. Thus, we aimed to investigate the role of SEMA7A in hepatic fibrosis...
  12. pmc Disease-specific proteins from rheumatoid arthritis patients
    Choong Won Kim
    Department of Biochemistry and RINS, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju, Korea
    J Korean Med Sci 21:478-84. 2006
    ..Fibronectin, semaphorin 7A precursor, growth factor binding protein 7 (GRB7), and immunoglobulin mu chain were specifically associated ..
  13. pmc Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy
    Yan Zheng
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Mol Immunol 55:283-91. 2013
    ..including lymphocyte-activation gene 3 (Lag3), Class-I-MHC-restricted T cell associated molecule (Crtam), Semaphorin 7A (Sema7A), and chemokine CCL1...
  14. pmc An Imbalance between Frequency of CD4+CD25+FOXP3+ Regulatory T Cells and CCR4+ and CCR9+ Circulating Helper T Cells Is Associated with Active Perennial Allergic Conjunctivitis
    J Galicia-Carreón
    Department of Pharmacobiology, CINVESTAV, IPN, P O Box 22106, 14330 Mexico, DF, Mexico
    Clin Dev Immunol 2013:919742. 2013
    ..observed in frequency of Treg; however, an increased frequency of CD4+CCR4+CCR9+ cells, CD4+CD103+ cells and CD4+CD108+ cells with increased IL-5, IL-6, and IL-8 production was observed...
  15. doi Semaphorin 4A is dynamically regulated during thymocyte development in mice
    Grace E Linder
    Biology Department, Macalester College, St Paul, MN 55105, USA
    Cell Immunol 281:150-8. 2013
    ..b>Sema7a was expressed at very low levels, while Sema4d was abundant at all developmental stages of mouse thymocytes...
  16. doi Semaphorin7A: branching beyond axonal guidance and into immunity
    Ramon Garcia-Areas
    Department of Biomedical Sciences, Charles E Schmidt College of Medicine, Florida Atlantic University, 777 Glades Road, Boca Raton, FL, 33431 0991, USA
    Immunol Res 57:81-5. 2013
    ..Semaphorin7A (SEMA7A) belongs to the "immune" semaphorin group and has been shown to play a crucial role in regulating immune responses...
  17. pmc Endothelial Semaphorin 7A promotes neutrophil migration during hypoxia
    Julio César Morote-García
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, D 72076, Tubingen, Germany
    Proc Natl Acad Sci U S A 109:14146-51. 2012
    ..Previously unknown, we report here the expression and induction of semaphorin 7A (SEMA7A) on endothelium through hypoxia-inducible factor 1α during hypoxia...
  18. pmc Limk2 mediates semaphorin signalling in cortical interneurons migrating through the subpallium
    William D Andrews
    Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Biol Open 2:277-82. 2013
    ..migration, we identified LIM-kinase 2 (Limk2), a kinase previously shown to be involved in cell movement and in Sema7A-PlexinC1 signalling...
  19. doi Semaphorin7A and its receptors: pleiotropic regulators of immune cell function, bone homeostasis, and neural development
    Bart C Jongbloets
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, Utrecht, The Netherlands
    Semin Cell Dev Biol 24:129-38. 2013
    ..Although originally identified in immune cells, as CDw108, Sema7A displays widespread expression outside the immune system...
  20. doi Sex-specific changes in gene expression and behavior induced by chronic Toxoplasma infection in mice
    J Xiao
    Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Neuroscience 206:39-48. 2012
    ..e. downregulation of fatty acid-binding protein 7 and eyes absent homolog 1, upregulation of semaphorin 7A). In male mice, infection led mainly to modulation of genes associated with olfactory function (i.e...
  21. pmc Integrative assessment of chlorine-induced acute lung injury in mice
    George D Leikauf
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15219 3130, USA
    Am J Respir Cell Mol Biol 47:234-44. 2012
    ..The leading candidate genes associated with increased susceptibility to acute lung injury in mice included Klf4, Sema7a, Tns1, Aacs, and a gene that encodes an amino acid carrier, Slc38a4.
  22. doi Semaphorin 7A inhibits platelet production from CD34+ progenitor cells
    Y Jaimes
    Institute for Transfusion Medicine, Hanover Medical School, Hanover, Germany
    J Thromb Haemost 10:1100-8. 2012
    The multifunctional protein semaphorin 7A (Sema7A) may have regulatory effects on blood cell differentiation via its receptors β1-integrin and plexin C1...
  23. pmc Semaphorin 7a links nerve regeneration and inflammation in the cornea
    Abed Namavari
    Corneal Neurobiology Laboratory, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, 60612, USA
    Invest Ophthalmol Vis Sci 53:4575-85. 2012
    We determined Semaphorin 7a (Sema7a) localization and abundance in naive corneas and in corneas after nerve-transecting lamellar flap surgery, and determined the effect of Sema7a supplementation on corneal nerve regeneration and ..
  24. doi Effect of Bombax ceiba L. on spermatogenesis, sexual behaviour and erectile function in male rats
    C Bhargava
    Advance Group of Pharmacy Colleges, Naramau Kanpur, India
    Andrologia 44:474-8. 2012
    ..It has been corrected to Bombacaceae] also known as Semal Musli are used traditionally in Indian subcontinent as sexual stimulant...
  25. doi Semaphorin 7A protein variants differentially regulate T-cell activity
    Christiane Gras
    Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Transfusion 53:270-83. 2013
    b>Semaphorin 7A (Sema7A) carries the John-Milton-Hagen human blood group antigen on red blood cells and shows molecular diversity...
  26. pmc Chromosome 15q24 microdeletion syndrome
    Pilar L Magoulas
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Orphanet J Rare Dis 7:2. 2012
    ..2 Mb region between LCR15q24B to LCR15q24C. There are several candidate genes within the SRO, including CYP11A1, SEMA7A, CPLX3, ARID3B, STRA6, SIN3A and CSK, that may predispose to many of the clinical features observed in individuals ..
  27. pmc Semaphorin-7a reverses the ERF-induced inhibition of EMT in Ras-dependent mouse mammary epithelial cells
    Maryline Allegra
    Medical School, University of Crete, Crete, Greece
    Mol Biol Cell 23:3873-81. 2012
    ..Our data suggest that oncogenic Ras may play an additional role in EMT via the ERF, regulating Semaphorin-7a and providing a new interconnection between the Ras- and the TGF-β-signaling pathways...
  28. pmc Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-β1/Smad6 signaling
    Hameeda Sultana
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 189:3150-8. 2012
    b>Semaphorin 7A (Sema7A) is a membrane-associated/secreted protein that plays an essential role in connecting the vertebrate neuronal and immune systems. However, the role of Sema7A has not been elucidated in viral pathogenesis...
  29. pmc Semaphorin 7a+ regulatory T cells are associated with progressive idiopathic pulmonary fibrosis and are implicated in transforming growth factor-β1-induced pulmonary fibrosis
    Ronald A Reilkoff
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Am J Respir Crit Care Med 187:180-8. 2013
    Lymphocytes are increasingly associated with idiopathic pulmonary fibrosis (IPF). Semaphorin 7a (Sema 7a) participates in lymphocyte activation.
  30. doi Semaphorins 3A and 7A: potential immune and neuroregenerative targets in multiple sclerosis
    Herena Eixarch
    Servei de Neurologia Neuroimmunologia, Centre d Esclerosi Múltiple de Catalunya Cemcat, Vall d Hebron Institut de Recerca VHIR, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Ps Vall d Hebron, 119 129, 08035 Barcelona, Spain
    Trends Mol Med 19:157-64. 2013
    ..In this article, we compile recent insights into the specific roles of semaphorin (sema)3A and sema7A to clarify the details of their possible participation in the inflammatory and neurodegenerative phases of MS.
  31. pmc Semaphorin-7A is an erythrocyte receptor for P. falciparum merozoite-specific TRAP homolog, MTRAP
    S Josefin Bartholdson
    Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom Malaria Programme, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    PLoS Pathog 8:e1003031. 2012
    ..Here, we identify the GPI-linked protein Semaphorin-7A (CD108) as an erythrocyte receptor for the P...
  32. ncbi Evidence that CDw108 membrane protein bears the JMH blood group antigen
    R Mudad
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Transfusion 35:566-70. 1995
    b>CDw108 is a cluster-of-differentiation antigen that resides on a glycosylphosphatidylinositol (GPI)-linked protein; it has not previously been shown to be expressed on red cells...
  33. ncbi Molecular cloning and expression of murine homologue of semaphorin K1 gene
    Y Sato
    Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194, Japan
    Biochim Biophys Acta 1443:419-22. 1998
    We have cloned a mouse homologue of semaphorin K1 cDNA...
  34. ncbi Serum levels of syndecan-1 in B-cell chronic lymphocytic leukemia: correlation with the extent of angiogenesis and disease-progression risk in early disease
    Stefano Molica
    Medical Oncology, Azienda Ospedaliera Pugliese Ciaccio, Catanzaro, Italy
    Leuk Lymphoma 47:1034-40. 2006
    ..110). The same applied with adhesion molecules such as CD54 (P = 0.233), CD108 (P = 0.799), CD44 (P = 0.816) and CD31 (P = 0.508). Interestingly, the inverse correlation (r = -0.4967; P = 0...
  35. pmc Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis
    Hye Ryun Kang
    Section of Pulmonary and Critical Care Medicine and 2Department of Pathology, Yale University School of Medicine, New Haven, CT 06519, USA
    J Exp Med 204:1083-93. 2007
    ..They also demonstrate that the effects of SEMA 7A are not specific for transgenic TGF-beta(1), highlighting the importance of these findings for other fibrotic stimuli...
  36. pmc Expression patterns of semaphorin7A and plexinC1 during rat neural development suggest roles in axon guidance and neuronal migration
    R Jeroen Pasterkamp
    Solomon H Snyder Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 1001 PCTB, 725 North Wolfe Street, Baltimore, MD 21205, USA
    BMC Dev Biol 7:98. 2007
    ..Semaphorin7A (Sema7A), the only glycosylphosphatidylinositol-anchored semaphorin, promotes axon growth in vitro and is required for the ..
  37. ncbi Cooperative activity of multiple upper layer proteins for thalamocortical axon growth
    Takuro Maruyama
    Neuroscience Laboratories, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    Dev Neurobiol 68:317-31. 2008
    ..lamina-specific TC axon termination, we investigated the responsiveness of TC axons to ephrin-A5, semaphorin-7A (Sema7A) and kit ligand (KL), which are expressed in the upper layers of the developing cortex...
  38. ncbi Gene expression profiling distinguishes a molecular signature for grade 1B mild acute cellular rejection in cardiac allograft recipients
    Daniel Bernstein
    Department of Pediatrics Cardiology, Stanford University, Stanford, California 94304, USA
    J Heart Lung Transplant 26:1270-80. 2007
    ..We explored the hypothesis that the rejection classifier also differentiates various forms of mild rejection and we performed sub-analyses based on time post-transplant and confirmatory pathology interpretations...
  39. ncbi The origins of human embryonic stem cells: a biological conundrum
    Thore C Brink
    Department of Vertebrate Genomics Molecular Embryology and Aging, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Cells Tissues Organs 188:9-22. 2008
    ..These genes are involved in signaling cascades (SEMA7A and MAP3K10), cell proliferation (CUZD1 and MS4A7) and chromatin remodeling (H1FOO and HRMT1L4)...
  40. doi Rapid detection of JMH antibodies with recombinant Sema7A (CD108) protein and the particle gel immunoassay
    Axel Seltsam
    Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Transfusion 48:1151-5. 2008
    ..Here, a novel method is described for detection of anti-JMH with particles coated with recombinant semaphorin 7A (Sema7A, CD108), the protein that carries the JMH blood group antigens.
  41. doi Intestinal epithelial cell-derived semaphorin 7A negatively regulates development of colitis via αvβ1 integrin
    Sujin Kang
    Department of Immunopathology, World Premier International Research Center, Osaka University, Suita City, Osaka 565 0871, Japan
    J Immunol 188:1108-16. 2012
    ..In this study, we report that semaphorin 7A (Sema7A), a GPI-anchored semaphorin expressed in intestinal epithelial cells (IECs), induces IL-10 production ..
  42. pmc Sema3D and Sema7A have distinct expression patterns in chick embryonic development
    Zheng Zheng Bao
    Department of Medicine and Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 02115, USA
    Dev Dyn 235:2282-9. 2006
    By RT-PCR, we isolated a partial cDNA clone for the chick Semaphorin7A (Sema7A) gene. We further analyzed its expression patterns and compared them with those of the Sema3D gene, in chick embryonic development...
  43. ncbi Semaphorin 7A is a negative regulator of T cell responses
    Agnieszka K Czopik
    Section of Immunobiology, Yale University, New Haven, Connecticut 06520, USA
    Immunity 24:591-600. 2006
    ..b>Semaphorin 7A (Sema7A) promotes axonal growth in the central nervous system...
  44. ncbi Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates
    L Tamagnone
    Institute for Cancer Research and Treatment, University of Torino, Candiolo, Italy
    Cell 99:71-80. 1999
    ..for the transmembrane semaphorin Sema4D (CD100), and plexin-C1 is a receptor for the GPI-anchored semaphorin Sema7A (Sema-K1)...
  45. ncbi CDw108 expression during T-cell development
    T Mine
    Kurume University Research Center for Innovative Cancer Therapy, Department of Surgery, Kurume University School of Medicine, Japan
    Tissue Antigens 55:429-36. 2000
    ..0% or 89.3% similarity at the nucleotide or amino acid level, respectively) or identical to the murine semaphorin K1/Sema7A...
  46. ncbi Structure and function of the immune semaphorin CD100/SEMA4D
    Abdellah Elhabazi
    Department of Biology, Faculty of Sciences, El Jadida Morocco
    Crit Rev Immunol 23:65-81. 2003
    ..A growing number of semaphorins--namely, human CD100/SEMA4D, CD108/SEMA7A, and SEMA3A; viral semaphorins, SemaVA and SemaVB; and, very recently, mouse Sema4A--were reported to regulate ..
  47. ncbi Expression and function of semaphorin 7A in bone cells
    Guillaume Delorme
    Laboratoire de Biologie Moleculaire de la Cellule, ENS CNRS 5161, IFR 128 Biosciences Lyon Gerland, 46 allee d Italie, 69007 Lyon, France
    Biol Cell 97:589-97. 2005
    ..However, it can promote axon outgrowth, acting through a beta1 subunit-containing integrin receptor...
  48. ncbi Odontoblast expression of semaphorin 7A during innervation of human dentin
    Jean Christophe Maurin
    Laboratoire du Developpement des Tissus Dentaires, ESPRI INSERM EA 1892, IFR 62, Faculté d Odontologie UNIV LYON 1, Rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    Matrix Biol 24:232-8. 2005
    b>Semaphorin 7A (SEMA 7A) is a membrane-anchored member of the semaphorin family of guidance proteins, previously identified in the immune system...
  49. ncbi Integrin-mediated dendrite branch maintenance requires Abelson (Abl) family kinases
    Eva Marie Yang Moresco
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520 8024, USA
    J Neurosci 25:6105-18. 2005
    ..Activation of integrin receptors by adhesion to laminin-1 or Semaphorin 7A also promotes neurite branching in cortical neurons, but this response is absent in arg-/- neurons because of ..
  50. ncbi Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid
    Yan Hu
    Department of Neurology, Division of Metabolism and Proteomics Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Proteomics 4:2000-9. 2005
    ..These results validate our method of identifying differences in proteomic profiles of CSF samples and have important implications for the design of CSF biomarker studies for AD and other central nervous system disorders...
  51. doi Spinal cord injury induces differential expression of the profibrotic semaphorin 7A in the developing and mature glial scar
    Marcel A Kopp
    Department of Neurology and Experimental Neurology, Spinal Cord Injury Research, Charite University Medicine Berlin, Chariteplatz 1, Berlin, Germany
    Glia 58:1748-56. 2010
    b>Semaphorin 7A (Sema7A) is involved in the formation of the central nervous system during development by operating axon guidance and neuronal migration...
  52. pmc Semaphorin 7A promotes angiogenesis in an experimental corneal neovascularization model
    Ramon C Ghanem
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, USA
    Curr Eye Res 36:989-96. 2011
    To characterize the involvement of Semaphorin 7A (Sema7a) in corneal neovascularization (NV).
  53. pmc Dietary and behavioral interventions protect against age related activation of caspase cascades in the canine brain
    Shikha Snigdha
    Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 6:e24652. 2011
    ..treated with an AOX arm showed reduced numbers of cells expressing active caspase 9 or its cleavage product semaphorin 7A, while ENR (but not AOX) reduced ceramide levels...
  54. doi Th1 cells promote neurite outgrowth from cortical neurons via a mechanism dependent on semaphorins
    Hiroshi Ishii
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 402:168-72. 2010
    ..Furthermore, experiments using knockout mice revealed that semaphorin 4A (Sema4A) but not Sema7A was required for the effect produced by Th1 cells...
  55. doi A new SEMA7A variant found in Native Americans with alloantibody
    M Richard
    Research and Development, HEMA QUEBEC, Quebec City, QC, Canada
    Vox Sang 100:322-6. 2011
    John Milton Hagen (JMH) antigens are carried by Semaphorin 7A that plays important roles in the nervous system and the immune responses. Its role on the erythrocytes is unclear...
  56. pmc Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1
    Heli Liu
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Cell 142:749-61. 2010
    ..b>Sema7A acts as both an immune and a neural Semaphorin through PlexinC1, and A39R is a Sema7A mimic secreted by smallpox ..
  57. doi The semaphorin 7A receptor Plexin C1 is lost during melanoma metastasis
    Rossitza Lazova
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06510, USA rossitza lazoraoyale edu
    Am J Dermatopathol 31:177-81. 2009
    ..b>Semaphorin 7A (Sema7A) is a membrane-linked semaphorin that is expressed by human keratinocytes, and we have shown that ..
  58. pmc Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity
    Shizue Ohsawa
    Department of Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 107:13366-71. 2010
    ..This caspase signaling leads to a cleavage of Semaphorin 7A, a membrane-anchored semaphorin that is required for the proper axonal projection...
  59. pmc Lateral rectus posterior fixation suture
    Jonathan M Holmes
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J AAPOS 14:132-6. 2010
    ..We report a small case series of patients successfully treated using a lateral rectus posterior fixation suture...
  60. doi Mechanical tension alters semaphorin expression in the periodontium
    Amber Y Spencer
    Department of Cell Biology and Anatomy, Center of Excellence in Oral and Craniofacial Biology, School of Dentistry, Louisiana State University Health Science Center, New Orleans, LA 70119, USA
    J Periodontol 80:1665-73. 2009
    ..We predicted that mechanical tension alters the expression of the subset of semaphorins in the periodontium likely to be most involved with regulating the remodeling of this tissue...
  61. doi Caspase-9 activation revealed by semaphorin 7A cleavage is independent of apoptosis in the aged olfactory bulb
    Shizue Ohsawa
    Department of Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, and CREST, JST, Bunkyo ku, Tokyo 113 0033, Japan
    J Neurosci 29:11385-92. 2009
    ..Here, we identified Semaphorin 7A (Sema7A) as a novel substrate for caspase-9 that can be used to monitor caspase-9 activity in mice, and found ..
  62. pmc Deciphering the human platelet sheddome
    Karen P Fong
    Department of Medicine, Division of Hematology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 117:e15-26. 2011
    ..As proof of principle, we validated one of the less frequently detected proteins, semaphorin 7A, which had not previously been identified in platelets...
  63. pmc Stimulus uncertainty and insensitivity to pitch-change direction
    Samuel R Mathias
    Department of Psychology, University of York, York YO10 5DD, United Kingdom
    J Acoust Soc Am 127:3026-37. 2010
    In a series of experiments, Semal and Demany [(2006). J. Acoust. Soc. Am...
  64. doi Isolation and purification of blood group antigens using immuno-affinity chromatography on short monolithic columns
    Andrea Mönster
    Institute for Technical Chemistry, Gottfried Wilhelm Leibniz Universität Hannover, Callinstraße 5, D 30167 Hanover, Germany
    J Chromatogr A 1218:706-10. 2011
    ..The proteins employed in this study are derived from blood group antigens Knops, JMH and Scianna, equipped both with a His-tag and with a V5-tag by which they can be purified...
  65. pmc Dysregulation of Semaphorin7A/β1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility
    Andrea Messina
    Department of Human and Animal Biology, University of Turin, Turin 10123, Italy
    Hum Mol Genet 20:4759-74. 2011
    ..Combining mouse genetics with in vitro models, we demonstrate that Semaphorin 7A (Sema7A) is essential for the development of the GnRH-1 neuronal system...
  66. doi Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is a potential tumor suppressor for melanoma progression
    Glynis A Scott
    Department of Dermatology, School of Medicine, University of Rochester, Rochester, New York, USA
    J Invest Dermatol 129:954-63. 2009
    ..Our previous data showed that semaphorin 7A (Sema7A), a protein involved in axon guidance, stimulates melanocyte adhesion and dendricity through opposing ..
  67. doi The action of Semaphorin7A on thalamocortical axon branching
    Akiko Fukunishi
    Laboratory of Cellular and Molecular Neurobiology, Graduate School of Frontier Biosciences, Osaka University, Yamadaoka, Suita, Osaka, Japan
    J Neurochem 118:1008-15. 2011
    ..In this study, we investigated the involvement of Semaphorin7A (Sema7A) in thalamocortical (TC) axon branching...
  68. ncbi Cerebrospinal fluid following cerebral ischemia accelerates the proliferation of bone marrow stromal cells in vitro
    Kimihiko Orito
    Department of Neurosurgery, Kurume University School of Medicine, Kurume, Japan
    Kurume Med J 57:21-8. 2010
    ..The expressions of CD34, CD45, CD90 and CD108 were assessed by flow cytometric analysis...
  69. pmc Secretome signature of invasive glioblastoma multiforme
    Catherine A Formolo
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Avenue NW, Washington, D C 20010, USA
    J Proteome Res 10:3149-59. 2011
    ..Antibody inhibition of CH3L1 reduced U87 cell invasiveness by 30%...
  70. doi Demographic and psychosocial factors associated with appointment attendance among HIV-positive outpatients
    Lina Bofill
    Department of Epidemiology and Public Health, University of Miami, Miller School of Medicine, FL, USA
    AIDS Care 23:1219-25. 2011
    ..eight adult participants attending the Outpatient Adult HIV/AIDS Immunology Clinic at Jackson Memorial Hospital (JMH) in Miami, Florida participated in the study...
  71. doi Semaphorin 7A on keratinocytes induces interleukin-8 production by monocytes
    Masahiro Kamata
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Dermatol Sci 62:176-82. 2011
    b>Semaphorin 7A (Sema7A) expressed on activated T cells stimulates cytokine production in monocytes through its receptor, α1β1 integrin.
  72. pmc Role of semaphorin 7a signaling in transforming growth factor β1-induced lung fibrosis and scleroderma-related interstitial lung disease
    Ye Gan
    Central South University, Changsha, Hunan, China
    Arthritis Rheum 63:2484-94. 2011
    b>Semaphorin 7a regulates transforming growth factor β1 (TGFβ1)-induced fibrosis...
  73. doi Gene profiles of THP-1 macrophages after in vitro exposure to respiratory (non-)sensitizing chemicals: identification of discriminating genetic markers and pathway analysis
    Sandra Verstraelen
    Unit Environmental Risk and Health, Flemish Institute for Technological Research VITO NV, Boeretang 200, 2400 Mol, Belgium
    Toxicol In Vitro 23:1151-62. 2009
    ..discriminating genes which were categorized into molecular and biological Gene Ontology (GO) terms, EIF4E, PDGFRB, SEMA7A, and ZFP36L2 could be associated with respiratory sensitization...

Research Grants70

  1. NEURODEVELOPMENTAL OUTCOME OF IN UTERO COCAINE EXPOSURE
    Emmalee Bandstra; Fiscal Year: 1993
    ..population of 2,250 North American black women delivering at the University of Miami/Jackson Memorial Hospital (UM/)JMH)...
  2. PERIPHERAL CD8+ T CELL TOLERANCE
    Linda A Sherman; Fiscal Year: 2010
    ..involves enhanced expression of one or more negative costimulatory molecules, including;PD-1, NKG2a and Semaphorin 7A. PUBLIC HEALTH RELEVANCE: Understanding and enforcing immune tolerance mechanisms is important in preventing ..
  3. MECHANISMS OF DENDRITE FORMATION & MELANOSOME TRANSFER
    Glynis Scott; Fiscal Year: 2003
    ..abstract_text> ..
  4. Plexin signalling in melanocyte biology and melanoma progression
    Glynis A Scott; Fiscal Year: 2010
    ..Semaphorin 4D and semaphorin 7A regulate multiple cellular processes in other cell types, including neurite outgrowth and retraction, tumor ..
  5. Role of Prostaglandins & Phospholipase A in melanocytes
    Glynis Scott; Fiscal Year: 2009
    ..We hypothesize that PG and phospholipases stimulate HM dendricity, MS transfer & pigmentation through different mechanisms that act synergistically to modulate cutaneous pigmentation following UVR. ..
  6. Functional Genomics of Chemical -Induced Acute Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2007
    ..abstract_text> ..
  7. Growth Factor Protection in Acute Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2009
    ..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  8. Role of Metalloproteinases in Mucin Overproduction in COPD
    GEORGE DOUGLAS LEIKAUF; Fiscal Year: 2010
    ....
  9. Genetic Determinants of Nickel-induced Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2005
    ..Determination of the relative roles of the genetic loci linked to nickel sulfate exposure is likely to improve our understanding of the mechanisms involved in acute lung injury. ..
  10. PATHOGENESIS OF RETINOPATHY OF PREMATURITY
    Jonathan Holmes; Fiscal Year: 2003
    ....
  11. ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHY
    Daniel Bernstein; Fiscal Year: 2009
    ..However, our data suggest that the intricacies of b-AR subtype signaling, the temporal dependence of this signaling, and the multiple pathways of potential crosstalk, are quite a bit more complex. ..
  12. ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHY
    Daniel Bernstein; Fiscal Year: 2010
    ..However, our data suggest that the intricacies of b-AR subtype signaling, the temporal dependence of this signaling, and the multiple pathways of potential crosstalk, are quite a bit more complex. ..
  13. Expression and regulation of the axon guidance cues
    Zheng Zheng Bao; Fiscal Year: 2009
    ....
  14. OUTCOME MEASURES FOR CLINICAL TRIALS IN STRABISMUS
    Jonathan Holmes; Fiscal Year: 2007
    ..Ultimately this research will result in better quality of life for patients with strabismus. ..
  15. ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHY
    Daniel Bernstein; Fiscal Year: 2004
    ..abstract_text> ..
  16. ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHY
    Daniel Bernstein; Fiscal Year: 2007
    ..However, our data suggest that the intricacies of b-AR subtype signaling, the temporal dependence of this signaling, and the multiple pathways of potential crosstalk, are quite a bit more complex. ..
  17. When Belief Becomes False Memory: A Processing Account
    Daniel Bernstein; Fiscal Year: 2003
    ..The proposed work will help clarify the relationship between belief and memory, thereby delineating some of the mechanisms responsible for false memory. ..
  18. High Resolution Ultrasound Biomicroscopy System
    Daniel Bernstein; Fiscal Year: 2005
    ....